CN102015718A - 1-(7-(六氢吡咯并[3,4-c]-吡咯-2(1h)-基)喹啉-4-基)-3-(吡嗪-2-基)脲衍生物和相关的化合物作为糖原合成酶激酶3(gsk-3) - Google Patents
1-(7-(六氢吡咯并[3,4-c]-吡咯-2(1h)-基)喹啉-4-基)-3-(吡嗪-2-基)脲衍生物和相关的化合物作为糖原合成酶激酶3(gsk-3) Download PDFInfo
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- CN102015718A CN102015718A CN2009801155844A CN200980115584A CN102015718A CN 102015718 A CN102015718 A CN 102015718A CN 2009801155844 A CN2009801155844 A CN 2009801155844A CN 200980115584 A CN200980115584 A CN 200980115584A CN 102015718 A CN102015718 A CN 102015718A
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
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- Hospice & Palliative Care (AREA)
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- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
实施例 | GSK-3βIC50 |
1 | ++ |
3 | ++ |
7 | ++ |
8 | +++ |
9 | +++ |
10 | +++ |
11 | ++ |
12 | ++ |
Claims (31)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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EP08155133.5 | 2008-04-24 | ||
EP08155133 | 2008-04-24 | ||
PCT/EP2009/054987 WO2009130317A1 (en) | 2008-04-24 | 2009-04-24 | 1- (7-(hexahydropyrrolo [3, 4-c] pyrrol-2 (1h) -yl) quin0lin-4-yl) -3- (pyrazin-2-yl) urea derivatives and related compounds as glycogen synthase kinase 3 (gsk-3) |
Publications (2)
Publication Number | Publication Date |
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CN102015718A true CN102015718A (zh) | 2011-04-13 |
CN102015718B CN102015718B (zh) | 2014-12-10 |
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CN200980115584.4A Expired - Fee Related CN102015718B (zh) | 2008-04-24 | 2009-04-24 | 作为糖原合酶激酶3抑制剂的1-(7-(六氢吡咯并[3,4-c]-吡咯-2(1h)-基)喹啉-4-基)-3-(吡嗪-2-基)脲衍生物和相关的化合物 |
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US (1) | US8455648B2 (zh) |
EP (1) | EP2297154B1 (zh) |
JP (1) | JP5756011B2 (zh) |
CN (1) | CN102015718B (zh) |
CA (1) | CA2720659C (zh) |
ES (1) | ES2418457T3 (zh) |
MX (1) | MX2010011663A (zh) |
WO (1) | WO2009130317A1 (zh) |
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CN103476766A (zh) * | 2010-12-30 | 2013-12-25 | Abbvie德国有限责任两合公司 | 杂环化合物和它们作为糖原合酶激酶-3抑制剂的用途 |
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EP2332939A1 (en) * | 2009-11-26 | 2011-06-15 | Æterna Zentaris GmbH | Novel Naphthyridine derivatives and the use thereof as kinase inhibitors |
MX336726B (es) | 2010-09-27 | 2016-01-27 | Abbott Gmbh & Co Kg | Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintasa quinasa-3. |
US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103476766A (zh) * | 2010-12-30 | 2013-12-25 | Abbvie德国有限责任两合公司 | 杂环化合物和它们作为糖原合酶激酶-3抑制剂的用途 |
CN103476766B (zh) * | 2010-12-30 | 2016-08-10 | Abbvie德国有限责任两合公司 | 杂环化合物和它们作为糖原合酶激酶-3抑制剂的用途 |
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ES2418457T3 (es) | 2013-08-13 |
JP2011518809A (ja) | 2011-06-30 |
CN102015718B (zh) | 2014-12-10 |
EP2297154B1 (en) | 2013-04-03 |
JP5756011B2 (ja) | 2015-07-29 |
US20110105528A1 (en) | 2011-05-05 |
CA2720659A1 (en) | 2009-10-29 |
WO2009130317A1 (en) | 2009-10-29 |
MX2010011663A (es) | 2011-01-21 |
US8455648B2 (en) | 2013-06-04 |
CA2720659C (en) | 2016-10-18 |
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