CN101987132A - Medicament for treating acne and preparation method thereof - Google Patents
Medicament for treating acne and preparation method thereof Download PDFInfo
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- CN101987132A CN101987132A CN 201010264929 CN201010264929A CN101987132A CN 101987132 A CN101987132 A CN 101987132A CN 201010264929 CN201010264929 CN 201010264929 CN 201010264929 A CN201010264929 A CN 201010264929A CN 101987132 A CN101987132 A CN 101987132A
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Abstract
The invention discloses a medicament for treating acne, which is characterized by being prepared mainly from the following raw materials in part by weight: 1 to 20 parts of rose, 1 to 20 parts of sevilleorange flower, 1 to 20 parts of folium mori, 1 to 20 parts of the root bark of the peony tree, 1 to 20 parts of virgin soil, 1 to 20 parts of Scutellaria baicalensis, 1 to 20 parts of chrysanthemum, 1 to 20 parts of gypsum, 1 to 20 parts of liquoric root and 1 to 20 parts of over 95 percent edible ethanol. The medicament can be absorbed by the spleen and stomach through oral administration or by skin through external administration or absorbed through the combination of the two modes. The medicament of the invention is reasonable in formula, simple in mixing, exact in treatment effect and capable of addressing both the symptoms and root causes. The invention also provides a method for preparing the medicament.
Description
Technical field
The invention belongs to the field of Chinese medicines, medicine of the treatment acne of particularly a kind of oral administration or external and preparation method thereof.
Background technology
Acne is comedo or acne again, is a kind of dermatosis by what hair follicle and sebaceous gland are blocked, inflammation caused.During adolescence, intravital hormone meeting stimulating hair growth promotes more heavy wool fat of smegma, and therefore hair and sebaceous gland pile up many materials, make the attached work of oils and fats and antibacterial, cause the reaction of red swelling of the skin.Because this symptom is common in youth of both sexes, so claim that just it is " comedo ".
Skin is the mirror of the five internal organs.The generation of small pox is main and the vital organs of the human body are in close relations, and motherland's medical research shows: closely bound up with visceral dysfunction though acne is grown in skin surface, the traditional Chinese medical science thinks that the reason that causes acne is:
One, wind and heat in the lung meridian card: show as Blushing, Fen Ci inflammation heat, pruritus, or symptoms such as pustule, yellow and thin fur, red tongue, thready and rapid pulse are arranged.
Two, syndrome of dampness-heat of spleen and stomach: the red and swollen pruritus of erythra, often not smooth with stool, dyspepsia, abdominal distention, yellow and greasy fur, symptoms such as slippery and rapid pulse.
Three, syndrome of stagnation of liver qi: be more common in the woman, erythra is shown effect repeatedly, with menstrual cycle obvious relation between persistence is arranged.
Four, syndrome of yin deficiency of liver and kidney: be more common in the adult more than 30 years old, the erythra color is red not bright, common dim complexion, pigmentation, spiritlessness and weakness, white and thin fur, symptoms such as soft pulse cunning.
Chinese patent CN200710304711.8 discloses a kind of Chinese medicine for oral administration for the treatment of acne, is to be made by 50 pleasant impression Chinese crude drugs such as Radix Rubiae, the Fructus Kochiae, Cortex Dictamni.The used medical material of this Chinese medicine is of a great variety.Chinese patent CN200410012451.3 discloses a kind of Chinese medicine preparation for the treatment of acne, skin sore, comedo, its raw material of making active ingredient forms and ratio of weight and number is: Flos Lonicerae 15-25, Flos Chrysanthemi Indici 8-12, Herba Taraxaci 20-30, Herba Violae 9-15, Fructus Forsythiae 8-12, Myrrha 6-10, Radix Polygoni Multiflori 8-12, Rhizoma Paridis 8-12, Radix Glycyrrhizae 4-8, Bombyx Batryticatus 6-8, dosage form is tablet or capsule.Chinese patent CN200510003033.2 discloses a kind of liniment for the treatment of acne, formulated by principal agent and adjuvant, the principal agent component and the consumption thereof of every 1000ml liniment are: turmeric oil 30～65ml, Rhizoma Paridis 40～60g, Herba Polygoni Perfoliati 40～60g, Herba Solidaginis 20～40g, Oleum Zingiberis corallini 30～65ml, Herba Gynostemmatis 20～60g, adjuvant component and consumption thereof are: polysorbate-8020ml, glycerol 50ml, azone 10ml.
The Chinese medicine product of above-mentioned treatment acne is paid attention to regulating too much, and used taste of Chinese medicine number is too much, has reduced the medicine proportion of a therapeutical effect relatively, has influenced the pharmic function performance, so effect is slow, the course of treatment is long, and effect is undesirable.And existing Chinese medicine oral administration but can not external, but can not the taking orally again of external, route of administration is single, makes the patient slow to the absorption of medicine.Chinese medicine for oral administration not only absorbs slowly, and causes spleen injury easily, even increase the weight of the state of an illness for the patient of weakness of the spleen and stomach.
Chinese medicine is taken difficulty owing to mostly be decoction or the pill that boils than Western medicine, has also influenced the popularization of Chinese medicine widely.
Summary of the invention
The objective of the invention is to overcome the defective that prior art exists, a kind of reasonable recipe is provided, compatibility is simplified, the medicine of the treatment acne of determined curative effect, treating both the principal and secondary aspects of a disease, to control, control foster combination, and this medicine can take orally by taste absorb again can external by skin absorbs, can also oral administration and externally used dual mode composite absorption.This compound administering mode helps the efficient absorption of human body to medicine, and for the crowd of weakness of the spleen and stomach, the medicine that is busy with one's work, spares oneself provides multiple choices, especially the patient by the modern job crowd is accepted.
Technical scheme of the present invention is as follows:
A kind of medicine for the treatment of acne, it is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part on Folium Mori, 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part in the Radix Rehmanniae, 1 ~ 20 part of Radix Scutellariae, 1 ~ 20 part of Flos Chrysanthemi, 1 ~ 20 part of Gypsum Fibrosum, 1 ~ 20 part in Radix Glycyrrhizae, content are 1 ~ 20 part of edible ethanol more than 95%.
Further, the consumption of each component of medicine of the present invention is: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts on Folium Mori, 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts in the Radix Rehmanniae, 15 ~ 20 parts of Radix Scutellariaes, 15 ~ 20 parts of Flos Chrysanthemis, 15 ~ 20 parts of Gypsum Fibrosum, 15 ~ 20 parts in Radix Glycyrrhizae, content are 15 ~ 20 parts of edible ethanols more than 95%.
The middle survival dose of above compatibility is the crude drug amount.
In order to strengthen the transdermal effect of medicine, can also mix transdermal agent in the medicine of the present invention, preferably weight portion is 1 ~ 5 part a azone.
Another object of the present invention provides manufacturing method for above mentioned medicine, it is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Folium Mori, Cortex Moutan, the Radix Rehmanniae, Radix Scutellariae, Flos Chrysanthemi, Gypsum Fibrosum and the Radix Glycyrrhizae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of acne.
Further, among the step c, can add in the aqueous solution of alcohol together by azone step a is extract obtained and 1 ~ 5 weight portion.
The conventional extracting method of described Chinese crude drug can adopt decocting method, circumfluence method, infusion process, percolation, semi-bionic extraction, supercritical fluid extraction, microwave extraction method etc. according to the kind of medical material.
Acne is a lung meridian heat in blood stasis, or due to the reason such as retention of heat in the spleen and stomach is stifling.The present invention is directed to the characteristics of acne, select Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Folium Mori, Cortex Moutan, the Radix Rehmanniae, Radix Scutellariae, Flos Chrysanthemi, Gypsum Fibrosum, Radix Glycyrrhizae for use,, make to contain pure Chinese medicine extraction liquid being that edible ethanol more than 95% mixes with content after each flavor Chinese medicine extraction.Employing to be to control, and control and support bonded method, but not only also external of oral administration of the medicine of making is a kind of reasonable recipe, and compatibility is simplified, the medicine of the treatment acne of determined curative effect, treating both the principal and secondary aspects of a disease.
The Folium Mori bitter but sweet flavor, cold, go into lung, Liver Channel; Expelling wind and clearing away heat, cooling blood for improving eyesight.The Cortex Moutan cold nature, the bitter in the mouth suffering is gone into the heart, liver, kidney channel; Purify the blood promoting blood circulation to remove blood stasis.Radix Rehmanniae sweet in the mouth; Bitter; Be slightly cold GUIXIN; Liver; Kidney channel; Nourishing YIN and clearing away heat; Removing heat from blood is enriched blood.Radix Scutellariae nature and flavor hardship, cold, go into the heart, lung, gallbladder, large intestine channel; The removing the relative excess fire, except that damp and hot, hemostasis.Flos Chrysanthemi nature and flavor sweetness and bitterness, lung, Liver Channel are gone in cold; Dispelling wind, heat clearing away makes eye bright, detoxifcation.Gypsum Fibrosum heat clearing away cooling, promoting the production of body fluid to quench thirst; Gypsum Fibrosum preparata heat clearing away, convergence, granulation promoting.The Radix Glycyrrhizae nature and flavor are sweet, and are flat, go into spleen, stomach, lung meridian; With middle emergency, lung moistening, detoxifcation, coordinating the actions of various ingredients in a prescription.
Amass heat with Radix Scutellariae, Gypsum Fibrosum lung heat clearing stomach among the present invention; Cortex Moutan removing heat from blood and promoting blood circulation: with the merit of the collaborative Cortex Moutan of the Radix Rehmanniae with the enhancing clearing away heat and cooling blood; Folium Mori, the clear part of the body cavity above the diaphragm housing the heart and lungs wind heat of Flos Chrysanthemi; Radix Glycyrrhizae and middle detoxifcation.All medicines cooperates, and can reach cleaning heat and expelling wind, removing heat from blood and promoting blood circulation effect, so with more than effect.
Flos Rosae Rugosae regulate the flow of vital energy resolving depression and blood dissipating blood stasis; The CitrusaurantiumL.Var.amara Engl. the chest stuffiness relieving of regulating the flow of vital energy, dispersing the stagnated liver-QI for regulating the stomach, appetizing preventing or arresting vomiting.Two medicines, 5 usefulness, a gas one blood, QI and blood is two transfers, eliminating turbid pathogen with aromatics, the appetizing of being amusing, the strength enhancing that absorbs the drug when oral.Content is the edible ethanol blood circulation promoting and blood stasis dispelling more than 95%, promotes that drug osmotic to cell absorbs, and auxiliary taste absorb to improve curative effect when oral; Outer time spent skin expansion pore is to strengthen the drug transdermal trap.
Medicine of the present invention can be smeared the affected part with medicine of the present invention except for oral administration, and the efficacy of a drug sick institute that goes directly so can remove the patient suffering, obtains and imitates in no time.This medicine is applicable to that also whole body smears.Adopt oral administration and externally usedly, drug effect is more remarkable.
It is obvious that the present invention treats the acne curative effect, and clinical usefulness repeatly, effect are very prompt.Medicine of the present invention is through clinical 100 routine patients' clinical verification, and curing number is 80 examples, and significant figure is 18 examples, and invalid number is 2 examples, and total effective rate reaches 98%.Do not see toxic side effect in the therapeutic process, the patient has better curative effect to obstinate.
For further specifying therapeutic effect, it is as follows now to enumerate model case:
Case 1: certain man 17 years old, there are skin sore, redness in the facial area many places.Oral medicine of the present invention, each 10 milliliters, every day 3 times, above symptom was alleviated in 3 days, eliminated in 16 days.Paying a return visit after 6 months does not have recurrence.
Case 2: certain woman 20 years old, facial corse sweat pore, length have many acne, facial red and swollen.Once took the Chinese medicine of multiple treatment acne, but effect is all not good.External medicine of the present invention is smeared whole body and face, and every day 2 times, each 10 milliliters, repeatedly smear at facial place.Above symptom was alleviated in 2 days, eliminated in 12 days.Paying a return visit after individual month does not have recurrence.
Case 3: certain man 25 years old, face, the multiple furuncle and phyma in back.Once took the Chinese medicine of multiple treatment acne, but effect is all not good.Oral medicine of the present invention, each 10 milliliters, every day 3 times; This medicine of external is smeared whole body and facial back, and every day 2 times, each 10 milliliters, repeatedly smear at place, facial back.Oral and external was alleviated after 1 day, eliminated in 10 days.Paying a return visit after 12 months does not have recurrence.
The specific embodiment
Embodiment 1
Take by weighing 15 parts of Flos Rosae Rugosaes, 18 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts on Folium Mori, 18 parts of Cortex Moutans, 15 parts in the Radix Rehmanniae, 16 parts of Radix Scutellariaes, 15 parts of Flos Chrysanthemis, 15 parts of Gypsum Fibrosum, 19 parts in Radix Glycyrrhizae adopts the method that decocts the back concentrating under reduced pressure to make Chinese medicine extract respectively, and is standby.
Under the room temperature, get the deionized water of 5 ~ 6 times of amounts, add content and be 18 parts of 96% edible ethanols, be mixed with aqueous solution of alcohol, standby.
Above-mentioned various Chinese medicine extract are added in the aqueous solution of alcohol, fully stirred 120 minutes, precipitate 2 ~ 4 hours, supernatant 200 orders filter, and gained filtrate is the medicine of the treatment acne of oral administration or external, carries out fill under aseptic condition.Gained precipitate and filtering residue focus on.
Embodiment 2
The drug component proportioning is: 18 parts of Flos Rosae Rugosaes, and 19 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts on Folium Mori, 18 parts of Cortex Moutans, 18 parts in the Radix Rehmanniae, 19 parts of Radix Scutellariaes, 19 parts of Flos Chrysanthemis, 19 parts of Gypsum Fibrosum, 20 parts in Radix Glycyrrhizae, content is 18 parts of 97% edible ethanols.Other is identical with embodiment 1.
Embodiment 3
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 20 parts on Folium Mori, 19 parts of Cortex Moutans, 19 parts in the Radix Rehmanniae, 20 parts of Radix Scutellariaes, 20 parts of Flos Chrysanthemis, 20 parts of Gypsum Fibrosum, 20 parts in Radix Glycyrrhizae, content is 18 parts of 98% edible ethanols.Other is identical with embodiment 1.
Embodiment 4
The drug component proportioning is: 16 parts of Flos Rosae Rugosaes, and 17 parts of CitrusaurantiumL.Var.amara Engl.s, 16 parts on Folium Mori, 17 parts of Cortex Moutans, 17 parts in the Radix Rehmanniae, 16 parts of Radix Scutellariaes, 15 parts of Flos Chrysanthemis, 16 parts of Gypsum Fibrosum, 17 parts in Radix Glycyrrhizae, content is 16 parts of 99% edible ethanols.Other is identical with embodiment 1.
Embodiment 5
The drug component proportioning is: 17 parts of Flos Rosae Rugosaes, and 18 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts on Folium Mori, 19 parts of Cortex Moutans, 18 parts in the Radix Rehmanniae, 18 parts of Radix Scutellariaes, 19 parts of Flos Chrysanthemis, 19 parts of Gypsum Fibrosum, 18 parts in Radix Glycyrrhizae, content is 19 parts of 100% edible ethanols.Other is identical with embodiment 1.
Embodiment 6
The drug component proportioning is: 19 parts of Flos Rosae Rugosaes, and 20 parts of CitrusaurantiumL.Var.amara Engl.s, 18 parts on Folium Mori, 20 parts of Cortex Moutans, 18 parts in the Radix Rehmanniae, 19 parts of Radix Scutellariaes, 20 parts of Flos Chrysanthemis, 19 parts of Gypsum Fibrosum, 20 parts in Radix Glycyrrhizae, content is 20 parts of 97% edible ethanols.Other is identical with embodiment 1.
Claims (5)
1. medicine for the treatment of acne, it is characterized in that it mainly is to be made by the raw material of following weight portion: 1 ~ 20 part of Flos Rosae Rugosae, 1 ~ 20 part of CitrusaurantiumL.Var.amara Engl., 1 ~ 20 part on Folium Mori, 1 ~ 20 part of Cortex Moutan, 1 ~ 20 part in the Radix Rehmanniae, 1 ~ 20 part of Radix Scutellariae, 1 ~ 20 part of Flos Chrysanthemi, 1 ~ 20 part of Gypsum Fibrosum, 1 ~ 20 part in Radix Glycyrrhizae, content are 1 ~ 20 part of edible ethanol more than 95%.
2. medicine as claimed in claim 1, it is characterized in that it mainly is to be made by the raw material of following weight portion: 15 ~ 20 parts of Flos Rosae Rugosaes, 15 ~ 20 parts of CitrusaurantiumL.Var.amara Engl.s, 15 ~ 20 parts on Folium Mori, 15 ~ 20 parts of Cortex Moutans, 15 ~ 20 parts in the Radix Rehmanniae, 15 ~ 20 parts of Radix Scutellariaes, 15 ~ 20 parts of Flos Chrysanthemis, 15 ~ 20 parts of Gypsum Fibrosum, 15 ~ 20 parts in Radix Glycyrrhizae, content are 15 ~ 20 parts of edible ethanols more than 95%.
3. medicine as claimed in claim 1 or 2 is characterized in that described medicine comprises that also weight portion is 1 ~ 5 part a azone.
4. the preparation method of the described medicine of one of claim 1 to 3 is characterized in that comprising the following steps:
A) take by weighing Flos Rosae Rugosae, CitrusaurantiumL.Var.amara Engl., Folium Mori, Cortex Moutan, the Radix Rehmanniae, Radix Scutellariae, Flos Chrysanthemi, Gypsum Fibrosum and the Radix Glycyrrhizae of described weight proportion, according to the conventional extracting method of Chinese medicine, the extract of the former medicine that obtains respectively respectively to distinguish the flavor of;
B) under the room temperature, get the deionized water of 5 ~ 6 times of amounts, the content that adds described weight proportion is the edible ethanol more than 95%, is mixed with aqueous solution of alcohol;
C) with in the above-mentioned aqueous solution of alcohol of the extract obtained adding of step a, stirred 120 minutes, precipitate 2 ~ 4 hours, filter, gained filtrate sterilization, fill according to quantity must be treated the medicine of acne.
5. preparation method as claimed in claim 4 is characterized in that, among the step c, azone step a is extract obtained and described weight proportion adds aqueous solution of alcohol together.
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| CN2010102649297A CN101987132B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating acne and preparation method thereof |
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| CN2010102649297A CN101987132B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating acne and preparation method thereof |
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| CN101987132A true CN101987132A (en) | 2011-03-23 |
| CN101987132B CN101987132B (en) | 2012-11-21 |
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| CN2010102649297A Expired - Fee Related CN101987132B (en) | 2010-08-27 | 2010-08-27 | Medicament for treating acne and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977131A (en) * | 2014-04-30 | 2014-08-13 | 卞佳林 | Traditional Chinese medicine preparation for treating acne and preparing method and application thereof |
| CN108542979A (en) * | 2018-04-25 | 2018-09-18 | 上海市同济医院 | A kind of natural herb flowers tea-drinking of speckle removing, acne removing beautifying face and moistering lotion |
| CN110150664A (en) * | 2019-06-26 | 2019-08-23 | 中国农业大学 | A kind of rose functional food improving acne |
Citations (3)
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|---|---|---|---|---|
| CN101264287A (en) * | 2008-04-07 | 2008-09-17 | 张志英 | Orally-administered Chinese medicine for treating acne and preparation thereof |
| CN101584794A (en) * | 2008-12-08 | 2009-11-25 | 芮育健 | Novel method for treating acne through heat clearing and dampness promotion of angelica, flavescent sophora and fresh rehmannia |
| CN101744931A (en) * | 2008-11-28 | 2010-06-23 | 天津天士力集团有限公司 | Acne dispelling traditional Chinese medicine composition and preparation, preparation method and application thereof |
-
2010
- 2010-08-27 CN CN2010102649297A patent/CN101987132B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101264287A (en) * | 2008-04-07 | 2008-09-17 | 张志英 | Orally-administered Chinese medicine for treating acne and preparation thereof |
| CN101744931A (en) * | 2008-11-28 | 2010-06-23 | 天津天士力集团有限公司 | Acne dispelling traditional Chinese medicine composition and preparation, preparation method and application thereof |
| CN101584794A (en) * | 2008-12-08 | 2009-11-25 | 芮育健 | Novel method for treating acne through heat clearing and dampness promotion of angelica, flavescent sophora and fresh rehmannia |
Non-Patent Citations (1)
| Title |
|---|
| 《北京中医》 20061231 李光宇，等 痤疮的中医治疗进展 756-758 1 第25卷, 第12期 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103977131A (en) * | 2014-04-30 | 2014-08-13 | 卞佳林 | Traditional Chinese medicine preparation for treating acne and preparing method and application thereof |
| CN108542979A (en) * | 2018-04-25 | 2018-09-18 | 上海市同济医院 | A kind of natural herb flowers tea-drinking of speckle removing, acne removing beautifying face and moistering lotion |
| CN110150664A (en) * | 2019-06-26 | 2019-08-23 | 中国农业大学 | A kind of rose functional food improving acne |
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| CN101987132B (en) | 2012-11-21 |
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