CN101961281B - Technology for preparing self-heating magnetic resonance application heating element - Google Patents
Technology for preparing self-heating magnetic resonance application heating element Download PDFInfo
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- CN101961281B CN101961281B CN 201010518466 CN201010518466A CN101961281B CN 101961281 B CN101961281 B CN 101961281B CN 201010518466 CN201010518466 CN 201010518466 CN 201010518466 A CN201010518466 A CN 201010518466A CN 101961281 B CN101961281 B CN 101961281B
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Abstract
The invention relates to technology for preparing a self-heating magnetic resonance application heating element. The self-heating magnetic resonance application heating element adopts the following components in part by weight: 8 to 12 parts of 20-30 nano magnetic iron oxide, 18 to 22 parts of 40-mesh activated carbon, 3 to 7 parts of NdFeB powder, 28 to 32 parts of 20-mesh activated carbon, 98 to 102 parts of 80-mesh reduction iron powder and 42 to 46 parts of physiological saline, and the heating element is prepared by grinding and stirring. The heating element is put into a storage heating element cabin consisting of a circular magnet ring, an upper permeable film and a lower permeable film; and a medicament is added on the lower permeable film and applied to a treatment spot of a human body. The heating element generates heat, and the heat first acts on the medicament through the lower permeable film, and then influences local applied skin and in vivo tissues to achieve a series of biological effects and fulfill the aim of treating diseases through rapid transdermal administration.
Description
Technical field
The present invention relates to a kind of technology for preparing self-heating magnetic resonance application heating element.
Background technology
Percutaneous dosing refers to adopt to be made the dosage form of specializing in external with medicine in suitable method and the substrate and imposes on skin (affected part or relevant acupuncture point), by the circulation of skin suction body or act on local skin and produce drug effect, reaches the Therapeutic Method of therapeutic purposes.Transdermal delivery system also claims transdermal drug delivery system.The Chinese medicine percutaneous drug administration preparation is with a long history, various in style, in recent years, along with the progress of preparation technique and the application of new drug usefulness adjuvant, develop the percutaneous dosing novel forms such as liniment, cataplasma, paster agent and sticked materials and methods, how it applies the time of staying more than three days at Pi skin Biao Mian Stickers, and the deposited local cover time of Yi Yin Qi Stickers causes the skin allergy phenomenon after for a long time.
Because oral administration need pass through the gastrointestinal tract first pass effect, and the circulation of the liver sausage after being absorbed, some ingredients are destroyed and can't form and treat the valid density gradient in this process, and it is imperative to seek new route of administration.Especially in recent years the U.S. succeed in developing the scopolamine paster be applied to the medical treatment clinical since, transdermal administration shows great potentiality, and causes increasing concern.The human body skin surface coverage has horny layer, is the most many-sided health barrier of human body, stops moisture and electrolytical forfeiture in the body, prevents that moisture from entering in the body, stops harmful substance damage body; Another function is Absorption.Percutaneous penetration of drugs enters the body circulation two approach, i.e. epidermis approach and appendages approach.The horny layer of skin is the main barrier of drug osmotic, and the key of transdermal administration is to promote the infiltration of medicine, also will avoid the stimulation to skin.
At present, promote that the method for drug transdermal infiltration is numerous, but very not as one wishes.Chemical promoter tends to cause the pharmaceutical chemistry reaction as the adding of cutaneous permeable agent; Iontophoretic technology and ultrasonic technology are used exclusive armarium and are realized, it is expensive inconvenient again.
Summary of the invention
Technical problem to be solved by this invention provides and a kind ofly can effectively promote Drug Percutaneous Absorption, the technology for preparing self-heating magnetic resonance application heating element that therapeutic effect is good.
The present invention adopts following technical scheme:
A kind of technology for preparing self-heating magnetic resonance application heating element, it is characterized in that it adopts following ratio of weight and number component: 20-30 nano-scale magnetic ferrum oxide 8-12 part, 40 purpose active carbon 18-22 parts, Nd-Fe-B powder 3-7 part, 20 purpose active carbon 28-32 parts, 80 purpose reduced iron powder 98-102 parts, normal saline 42-46 part, its preparation technology is as follows:
First 40 purpose active carbons are divided equally two parts by weight, join at twice in the above-mentioned 20-30 nano-scale magnetic ferrum oxide, the each requirement fully ground even and possessed flowability, add again Nd-Fe-B powder, stir, add again 20 purpose active carbons, and stir, stir after adding again normal saline, add reduced iron powder again after, stir rapidly, quantitatively pack into immediately and store up the heater storehouse, sealing, the outer bag of packing into rapidly again, sealing is namely made.
Good effect of the present invention is as follows:
Use when of the present invention, the present invention is inserted in the storage heater storehouse that is made of circle magnet ring, upper ventilated membrane and lower ventilated membrane, add medicine at lower ventilated membrane, it is sticked behind the human body therapy position, produce heat energy by heater of the present invention, see through lower ventilated membrane and at first act on medicine, impact sticks a series of biological effects such as local skin, in-vivo tissue then, has reached the purpose of rapid transdermal drug treatment disease.The present invention is widely used in and makes external application plaster medicament, cataplasma, adhesive bandage, adhesive bandage, dressing paste, applies umbilicus subsides, sufficient subsides, medical application, infusion patch series products.The present invention according to the thermotropism of biology in conjunction with thermodynamic principles, utilize the hot biological effect of magnetic in magnetic field, affect substrate medicine in the warehouse release, disturb the variation of skin resistance, current potential, affect kinestate and the high molecular magnetic moment orientation of histiocytic bioelectric current distribution, electric charge after acting on inside of human body, thereby impel the Transdermal absorption process that sticks medicine.Utilize the magnetic induction effect, after human body accept to stimulate, by affect inside and outside the cell membranes in tissue orientation of ion produce that local potential changes could be excited, conduction is got excited and is regulated the body function state; Under the heat power trend, act on keratodermatitis, make heated skin resistance be down to rapidly zero-bit, (annotate: the skin resistance barrier action is stronger) is beneficial to the effective ingredient transdermal; According to Faraday's electromagnetic induction theory, when conductor in magnetic field, if with the motion that meets at right angles of the magnetic line of force in magnetic field, in the skin conductor, just can produce faradic current, this phenomenon is in the present invention sticks human body therapy position 10-15 minute, use sensitive galvanometer and predict, and ammeter pointer always is partial to a side of Body contact.Thereby proof the inventive method makes heater and has changed the hot entropy of magnetic, and heat energy trend body treatment position also fully is absorbed, and has utilized to greatest extent heat energy; The magnetic induction of human body skin surface electrical can predict potential change, the current potential peak value of different parts is also different, current potential is higher, function of organization is stronger, utilize the office's skin histology after the detection of little electricity meter sticks, getting respectively 1,2,3,3,4,6,8,10,12 hour is test point, and its faradic current changed after 3 hours, current potential peak value in 8-10 hour can improve 10-16mv, descends rapidly after 12 hours.Therefore, we think skin point or therapentic part the time be limited to 8-12 hour and be advisable, treat once every day, but and continuous application.The present invention has thermotherapy, magnetic therapy, medication concurrently in one.
Description of drawings
Accompanying drawing 1 is deposited and attached structural representation of the present invention;
Accompanying drawing 2,3,4 is deposited and attached surface structure sketch map of the present invention.
The specific embodiment
Shown in accompanying drawing 1,2,3,4, be deposited and attached structural representation of the present invention, the described deposited and attached upper ventilated membrane 2 that comprises a round magnet ring 1, is fixedly installed on round magnet ring 1 upside, the storage heater storehouse 4 that is built-in with heater of the present invention that is fixedly installed on the lower ventilated membrane 3 of round magnet ring 1 downside, is consisted of by circle magnet ring 1, upper ventilated membrane 2 and lower ventilated membrane 3.Adopt the Self-heating magnetic resonance plaster of the present invention's preparation, deposit in the fully airtight packing of packing into, when the patient uses, open outer packaging bag, use the described airtight outer packaging bag of opening when deposited and attached, add the required medicine for the treatment of at lower ventilated membrane 3, it is sticked behind the human body therapy position, produce heat energy by heater of the present invention, see through lower ventilated membrane and at first act on the interior medicine of medicine holding bin, then impact sticks a series of biological effects such as local skin, in-vivo tissue, has reached the purpose of rapid transdermal drug treatment disease.
Describedly deposited and attachedly also can adopt round magnet ring 1 downside to be provided with medical adhesive strap 5, be provided with the medicine holding bin 7 that lower round magnet ring 6 consists of in medical adhesive strap 5 lower ends.Posted cotton pad sheet 8 at lower round magnet ring 6 interior medical adhesive straps 5.Posted release paper 9 at the lower round magnet ring 6 that consists of medicine holding bin 7, the magnetic induction of circle magnet ring 1 is 2000-2600GS, and the magnetic induction of lower round magnet ring 6 is 500-1000GS, all is marked with polarity N, S, annotate utmost point orientation from top to bottom, utilize magnetobiology characteristic treatment disease.Round magnet ring 1 of the present invention and lower round magnet ring 6 also can all adopt non-magnetic rubber ring.Adopt Self-heating magnetic resonance plaster of the present invention, deposit in the fully airtight packing of packing into, adopt deposited and attached applying method of the present invention: opposed method, singly put method, juxtaposition method.When the patient uses, open outer packaging bag, throw off antistick characteristic release paper 9, according to the needs for the treatment of relevant medicine is put into medicine holding bin 7, be attached at therapentic part, this moment, electro-heat equipment was in relative air-tight state, be that a small amount of air slowly enters in the heater storehouse 4 through upper ventilated membrane 2, heater of the present invention begins heat production in 10 minutes, and heat energy enters medicine holding bin 7 by lower ventilated membrane 3 immediately, and be combined into complex with drug effective region, and then affect skin histology.Medicine clinical research confirms at present, and the described deposited and attached process of Drug Percutaneous Absorption of impelling has three steps: the one, discharge, and refer to that medicine discharges and is diffused on skin or the mucosa from the substrate of medicine holding bin 7.The comprehensive effect that said method forms impels and sticks in the medicine surface and contain a large amount of activating agents, and it can promote passive diffusion and the absorption of medicine, increases mucocutaneous transmitance to medicine.The 2nd, penetrate, refer to that medicine sees through epidermis and enters endothelium.Continuous high temperature state in sticking process, allow the body surface part of medicament contact form the air-tight state that a kind of sweat is difficult to evaporate, keratodermatitis is expanded behind hydration be porous state, be easy to macromolecular drug and penetrate into subcutaneous tissue, the sweat of its local organization is sticked drug absorption and is softened into the release that fluid state is conducive to stroma ground substance more.In this simultaneously, moisture in the medicine can see through again lower ventilated membrane 3 and enter heater storehouse 4, the temperature of restriction electro-heat equipment, reduced iron powder in the heater of the present invention can form slow and lasting oxidation reaction again under wet environment, discharge heat energy, replenished the hysteresis of magnetothermal effect, and then promote again the looking for to motion of magnetic resonance, tend to again conversely thermo-molecular and enter medicine holding bin 7 through lower ventilated membrane 3, Marjoram Extract and the blood flow that can urge local subcutaneous tissue after the medicine heating accelerate.The 3rd, absorb, refer to medicine penetrate subcutaneous or mucosa after enter human circulation by blood vessel and produce general action, and then reach therapeutic purposes rapidly.Circle magnet ring 1 and different can be made into circle, ellipse, the square or rectangulars of lower round magnet ring 6 according to human body application treatment position, the external diameter of circle magnet ring 1 and lower round magnet ring 6 are that 2-8cm is best.
The used ferromagnet of the present invention (reduced iron powder) and paramagnet (20-30 nano-scale magnetic ferrum oxide) are under relative air-tight state, be in when magnetizing in the high-intensity magnetic field and can produce magnetothermal effect, cause lower ventilated membrane 3 to meet thermal expansion, mesh forms, under the heat power trend, act on keratodermatitis, be beneficial to the effective ingredient transdermal.Magnetizable material also has the magnetic lag effect in high-intensity magnetic field, can cause the unstability (sometimes hot and sometimes cold) of heat effect, for adding reduced iron powder, the present invention of solution magnetic lag eliminated hysteresis, thereby form adjustable controlled high temperature constant state, be that heater maintains between 41-42 ℃ all the time, this temperature is that human body sensory is comfortable, and the best temperature value of physical therapy.After the present invention sticks human body, begin heat production after 15 minutes, persistent fever can reach more than 12 hours.
Heater storage tank of the present invention namely justifies magnet ring 1 and lower circle magnet ring 6 becomes polarity magnetic rubber ring by ferrite, rubber, polyethylene composite injection molding, and they are reservoir bodies, provide the high-intensity magnetic field ring for heater of the present invention again.Be deposited with the up and down ventilated membrane 2,3 that is coated with by non-woven fabrics at magnetic rubber circle lateral surface, and because circle magnet ring 1 or lower circle magnet ring 6 are the magnetic rubber ring, can deform with the shape that sticks the skin surface different parts, thereby form relatively airtight state, provide environmental condition for heater produces the energy.
Heater of the present invention is comprised of permanent magnetism new material neodymium iron boron, nano magnetic iron oxide, reduced iron powder and active carbon.Nd-Fe-Bo permanent magnet material make become differ in size, different graininess, grind the molding heater with all the other materials.Under controlled condition, this irregular permanent magnet material is distributed in carries out in the heater looking for the motion to, magnetic molecule, the suspension vibration that rotation produces between the magnetic material, form lasting and constant magnetic resonance phenomenon, releasing magnetic energy and heat energy, looking for to vibration of magnetic also can affect the collaborative resonance effect of human tissue cell's biological magnetic field.According to Faraday's electromagnetic induction theory, when conductor in magnetic field, if with the motion that meets at right angles of the magnetic line of force in magnetic field, in conductor, just can produce faradic current, this phenomenon is in the present invention sticks human body therapy position 10-15 minute, use sensitive galvanometer and predict, and ammeter pointer always is partial to a side of Body contact.Thereby proof the inventive method makes heater and has changed the hot entropy of magnetic, and heat energy trend body treatment position also fully is absorbed, and has utilized to greatest extent heat energy.In clinical practice, after the present invention exsomatized, upper and lower surface was all felt high heat, yet is sticked human body after 10 minutes, and its heater is to the one side in the outside, and drop in temperature is to tepid state.
Shown in accompanying drawing 1,2,3, below the heater of the present invention, namely be provided with medicine holding bin 7 with the Body contact face, medicine holding bin 7 arranges the i.e. lower circle magnet ring 6 of water proof ring, in case medicine is excessive.Water proof ring is injection molded into strong polarity gained by compounded rubber magnetic, and namely justifying magnet ring 6 interior placement absorbent cottons down at the magnetic water proof ring is cotton pad sheet 8, can be widely used in the storage of the externally applied transdermal drug-delivery preparations such as liquid, Emulsion, unguentum, medicinal cake, powder, pill.In the magnetic water proof ring high-intensity magnetic field that namely lower circle magnet ring 6 forms, the effective ingredient in the medicine conductor can form ionization state, also is conducive to the Transdermal absorption of medicine.
Transdermal drug delivery system of the present invention has also been set up the administration control delivery, by upper and lower ventilated membrane 2,3 in the electro-heat equipment, active carbon consists of: the accurate air amount that at first is upper ventilated membrane 2 is the motive power of original transdermal drug delivery system to heater, airborne oxygen and hydrone are inhaled in the active carbon, and pulling magnetothermal effect, carbohydrate discharge and thermal energy causes lower ventilated membrane 3 film mesh open.Magnetic particle, magnetization nanoparticle and gas discharge into medicine holding bin, drug release and heat energy and cause keratodermatitis to expand, the mesh exploitation, and water (antiperspirant) evaporation and medicine suck body; Water liquid is by warehouse drug absorption and dilution, a part discharges and enters the heater recycling by lower ventilated membrane 3, after-heat and water and carbon dioxide are disposed to by ventilated membrane beyond the electro-heat equipment, have spurred in an orderly manner the release of medicine and body to the drug absorption process.
For making things convenient for the needs of partes corporis humani position treatment.Adopting deposited and attached medical adhesive tape of the present invention can be made into diameter is deposited and attached that 2cm-108cm differs in size.
Use Self-heating magnetic resonance plaster of the present invention to add related drugs application treatment position, application time is applied ointment or plaster the preparation needs more than three days by original external, shortens to below 10 hours and can fully be absorbed by the skin rear utilization.It is safe and efficient, nontoxic non-stimulated that the present invention uses, and the heat energy utilization is abundant, recoverable recycling also after using, and preparation technology is simple, cheap does not find again untoward reaction, and the patient also can treat voluntarily, and is easy to utilize.Transfer under the theory of more paying attention to health from paying attention to treatment current Medical Consumption patient, its DEVELOPMENT PROSPECT is more wide.
Embodiment 1:
A kind of technology for preparing self-heating magnetic resonance application heating element, it is characterized in that it adopts following ratio of weight and number component: 8 parts of 20-30 nano-scale magnetic ferrum oxides, 20 parts of 40 purpose active carbons, 7 parts of Nd-Fe-B powders, 28 parts of 20 purpose active carbons, 102 parts of 80 purpose reduced iron powders, 46 parts of normal saline, its preparation technology is as follows:
First 40 purpose active carbons are divided equally two parts by weight, join at twice in the above-mentioned 25 nano-scale magnetic ferrum oxides, the each requirement fully ground even and possessed flowability, add again Nd-Fe-B powder, stir, add again 20 purpose active carbons, and stir, stir after adding again normal saline, add reduced iron powder again after, stir rapidly, quantitatively pack into immediately and store up the heater storehouse, sealing, the outer bag of packing into rapidly again, sealing is namely made.
Embodiment 2:
A kind of technology for preparing self-heating magnetic resonance application heating element, it is characterized in that it adopts following ratio of weight and number component: 12 parts of 20-30 nano-scale magnetic ferrum oxides, 18 parts of 40 purpose active carbons, 3 parts of Nd-Fe-B powders, 30 parts of 20 purpose active carbons, 98 parts of 80 purpose reduced iron powders, 42 parts of normal saline, its preparation technology is as follows:
First 40 purpose active carbons are divided equally two parts by weight, join at twice in the above-mentioned 20 nano-scale magnetic ferrum oxides, the each requirement fully ground even and possessed flowability, add again Nd-Fe-B powder, stir, add again 20 purpose active carbons, and stir, stir after adding again normal saline, add reduced iron powder again after, stir rapidly, quantitatively pack into immediately and store up the heater storehouse, sealing, the outer bag of packing into rapidly again, sealing is namely made.
Embodiment 3:
A kind of technology for preparing self-heating magnetic resonance application heating element, it is characterized in that it adopts following ratio of weight and number component: 10 parts of 20-30 nano-scale magnetic ferrum oxides, 22 parts of 40 purpose active carbons, 5 parts of Nd-Fe-B powders, 32 parts of 20 purpose active carbons, 100 parts of 80 purpose reduced iron powders, 44 parts of normal saline, its preparation technology is as follows:
First 40 purpose active carbons are divided equally two parts by weight, join at twice in the above-mentioned 30 nano-scale magnetic ferrum oxides, the each requirement fully ground even and possessed flowability, add again Nd-Fe-B powder, stir, add again 20 purpose active carbons, and stir, stir after adding again normal saline, add reduced iron powder again after, stir rapidly, quantitatively pack into immediately and store up the heater storehouse, sealing, the outer bag of packing into rapidly again, sealing is namely made.
Claims (1)
1. technology for preparing self-heating magnetic resonance application heating element, it is characterized in that it adopts following ratio of weight and number component to make described Self-heating magnetic resonance plaster heater: 20-30 nano-scale magnetic ferrum oxide 8-12 part, 40 purpose active carbon 18-22 parts, Nd-Fe-B powder 3-7 part, 20 purpose active carbon 28-32 parts, 80 purpose reduced iron powder 98-102 parts, normal saline 42-46 part, its preparation technology is as follows:
First 40 purpose active carbons are divided equally two parts by weight, join at twice in the above-mentioned 20-30 nano-scale magnetic ferrum oxide, the each requirement fully ground even and possessed flowability, add again Nd-Fe-B powder, stir, then add 20 purpose active carbons, and stir, stir after adding again normal saline, then add reduced iron powder after, stir rapidly, quantitatively pack into immediately and store up the heater storehouse, sealing, the outer bag of packing into rapidly again, sealing is namely made.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010518466 CN101961281B (en) | 2010-10-25 | 2010-10-25 | Technology for preparing self-heating magnetic resonance application heating element |
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| CN 201010518466 CN101961281B (en) | 2010-10-25 | 2010-10-25 | Technology for preparing self-heating magnetic resonance application heating element |
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| CN101961281A CN101961281A (en) | 2011-02-02 |
| CN101961281B true CN101961281B (en) | 2013-01-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106551755A (en) * | 2016-11-30 | 2017-04-05 | 兰州交通大学 | A kind of magnetic Nano medication patch and preparation method thereof |
| CN109124864B (en) * | 2018-08-10 | 2020-10-09 | 青岛沃普艾斯日用品有限公司 | Hot application patch for temperature-sensitive thermogenic plant compatibility physical moxibustion and manufacturing method thereof |
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| CN101161219A (en) * | 2006-10-13 | 2008-04-16 | 日本派欧尼株式会社 | Heating body and method for manufacturing the same |
| CN101233209A (en) * | 2005-08-09 | 2008-07-30 | 花王株式会社 | Heating element and heating intermediate |
| CN201127670Y (en) * | 2007-08-16 | 2008-10-08 | 信阳核工业恒达实业公司干燥剂厂 | Spontaneous heating warm bag |
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2010
- 2010-10-25 CN CN 201010518466 patent/CN101961281B/en not_active Expired - Fee Related
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491271A (en) * | 2001-10-25 | 2004-04-21 | ������������ʽ���� | Exothermic composition and exothermic article using composition, and method for producing exothermic article |
| CN1496395A (en) * | 2002-05-20 | 2004-05-12 | 麦考尔株式会社 | Exothermic composition and exothermic body |
| CN101233209A (en) * | 2005-08-09 | 2008-07-30 | 花王株式会社 | Heating element and heating intermediate |
| CN101161219A (en) * | 2006-10-13 | 2008-04-16 | 日本派欧尼株式会社 | Heating body and method for manufacturing the same |
| CN101108150A (en) * | 2007-08-16 | 2008-01-23 | 信阳核工业恒达实业公司干燥剂厂 | Spontaneous heating thermal bag and method of manufacturing the same |
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