CN101953984B - Medicinal composition for treating urarthritis, preparation method thereof, preparation thereof and use thereof - Google Patents

Medicinal composition for treating urarthritis, preparation method thereof, preparation thereof and use thereof Download PDF

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Publication number
CN101953984B
CN101953984B CN200910182039.9A CN200910182039A CN101953984B CN 101953984 B CN101953984 B CN 101953984B CN 200910182039 A CN200910182039 A CN 200910182039A CN 101953984 B CN101953984 B CN 101953984B
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taste
radix
flos chrysanthemi
chrysanthemi indici
alcohol
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CN101953984A (en
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萧伟
丁岗
曹亮
陈俊
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Jiangsu Kanion Pharmaceutical Co Ltd
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Jiangsu Kanion Pharmaceutical Co Ltd
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Abstract

The invention discloses a medicinal composition for treating urarthritis, which is characterized by being prepared from the following traditional Chinese medicinal raw materials in part by weight: 0.1 to 15 parts of diverse wormwood herb, 0.1 to 15 parts of ash bark, 0.1 to 15 parts of thunberg fritillary bulb, 0.1 to 15 parts of wild chrysanthemum, 0.1 to 15 parts of caulis piperis futokadsurae, 0.1 to 15 parts of cortex acanthopanacis, 0 to 30 parts of schefflera kwangsiensis, 0 to 15 parts of mulberry, 0 to 15 parts of red flower, 0 to 30 parts of astragalus, 0 to 15 parts of ladybell root, 0 to 15 parts of pseudo-ginseng root and 0 to 15 parts of cassia twig. The invention also discloses a preparation method, a preparation and use of the medicinal composition. The medicinal composite has high safety, can relieve pain and resist inflammatory obviously, can effectively reduce low-blood uric acid, and is suitable for treating hyperur icemia and gout, particularly urarthritis.

Description

The treatment pharmaceutical composition of gouty arthritis and preparation method and preparation and purposes
Technical field
The present invention relates to a kind of take Chinese medicine as the pharmaceutical composition, particularly a kind of pharmaceutical composition for the treatment of gouty arthritis of raw material; The invention still further relates to the preparation method of this pharmaceutical composition, preparation and purposes.
Background technology
Gout (gout) is due to purine metabolic disturbance, and uric acid produces too much and/or underexcretion, and serum uric acid level continues to increase and causes urate crystal to be deposited on one group of metabolic disease caused by joint and soft tissue.
Gout clinical manifestation can be divided into 4 stages: incubation period (hyperuricemia phase), acute stage, intermission, chronic phase.Asymptomatic stage only shows as hyperuricemia and without any symptom, be developed to gout by asymptomatic hyperuricemia and generally experience the several years to many decades, but also have and gout does not occur throughout one's life, hyperuricemia (hyperuricemia) is the important biochemical basis of gout.Gout recurrent exerbation person was in progress gradually as the chronic arthritis phase, was more common in untreated or the not good patient for the treatment of, prevented the patient of hyperuricemia can without this phase in early days.Later stage can also cause nephropathy, shows as urate nephropathy, kidney urate calculus and acute renal failure.
Current China hyperuricemia sickness rate 10%, about 1.2 hundred million people.Gout sickness rate 1%, patient about 1,200 ten thousand.Modern medicine is still in the symptomatic treatment stage to the treatment of gout, and according to drug effect mode, chemical medicine can be divided into five classes: (1) suppresses granulocyte to infiltrate medicine, as colchicine; (2) uricopoiesis medicine is suppressed, as xanthine oxidase inhibitor allopurinol; (3) uricosureic agent, as probenecid, sulphinpyrazone, benzbromarone; (4) nonsteroidal anti-inflammatory, as naproxen, indomethacin, Phenylbutazone or crovaril, piroxicam; (5) glucocorticoid, as prednisone.Wherein many kinds are the old medicine of last century five, sixties exploitation, and side effect is comparatively large, and as medicine irritation, anaphylaxis, Liver and kidney toxicity, bone marrow depression etc., patient is difficult to continue application.Therefore the anti-gout drugs finding high-efficiency low-toxicity from Chinese medicine is the focus of research always.
The traditional Chinese medical science is thought, gout is mainly due to surfeit Sorghum vulgare Pers. savoury usually, accumulate in turbid damp poison heresy, affection of exogenous wind-cold, QI and blood is not smooth, in addition spleen kidney imbalance, wet, expectorant, the stasis of blood, the all evil numbness resistance passages through which vital energy circulates of heat form, therefore, adopt heat-clearing and toxic substances removing more, dampness removing is let out turbid, dispelling wind dredging collateral, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, the therapeutic rule of strengthening spleen, tonifying kidney, there are bone erosion defect and surrounding tissue fibrosis the chronic arthritis phase of gout more, ankylosis deformity also pain, tophus or calculus, mostly be deficiency of spleen and stomach, blood stasis, turbid damp impatency meridians, solidify and do not change, control suitable reinforcing spleen and kidney, promoting blood circulation to remove obstruction in the collateral, dampness removing is let out turbid.The Chinese patent medicine of current treatment gouty arthritis is still few, still can not meet the demand sharply risen to the gout Chinese patent medicine that effectively can reduce blood uric acid in market.
Summary of the invention
Technical problem to be solved by this invention be to provide a kind of newly, the pharmaceutical composition of compatibility is more reasonable, curative effect is better treatment gouty arthritis.
Another technical problem to be solved by this invention there is provided the preparation method of the pharmaceutical composition of multiple treatment gouty arthritis as above.
Another technical problem to be solved by this invention there is provided the pharmaceutical preparation that the pharmaceutical composition for the treatment of gouty arthritis as above or preparation method as above are made.
Pharmaceutical composition of the present invention can be used for treatment of arthritis, comprises rheumatic arthritis, rheumatoid arthritis, osteoarthritis, is also applicable to acute stage of gout and intermission.
Technical problem to be solved by this invention is realized by following technical scheme.The present invention is a kind of pharmaceutical composition for the treatment of gouty arthritis, is characterized in, it is made up of the raw material of Chinese medicine of following weight proportion,
Herba Artemisiae Anomalae 0.1 ~ 15; Cortex Fraxini 0.1 ~ 15; Bulbus Fritillariae Thunbergii 0.1 ~ 15;
Flos Chrysanthemi Indici 0.1 ~ 15; Caulis Piperis Kadsurae 0.1 ~ 15; Cortex Acanthopancis 0.1 ~ 15;
Radix Schefflerae Arboricolae 0 ~ 30; Fructus Mori 0 ~ 15; Flos Carthami 0 ~ 15;
The Radix Astragali 0 ~ 30; Radix Adenophorae 0 ~ 15; Radix Notoginseng 0 ~ 15;
Ramulus Cinnamomi 0 ~ 15.
In drug regimen composition formula of the present invention, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae and Cortex Acanthopancis 6 taste raw material are substantially square by described weight proportion composition; Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng and Ramulus Cinnamomi 7 taste raw material are optional raw materials; Any one in the optional raw material of 7 taste or multiplely substantially just can carry out prescription with above-mentioned 6 tastes; When weight proportion selection " 0 " of the optional raw material of 7 taste, represent in prescription not containing this raw material.
The pharmaceutical composition of above-described treatment gouty arthritis, the preferred weight proportioning of each raw material of Chinese medicine is: Herba Artemisiae Anomalae 6 ~ 10; Cortex Fraxini 6 ~ 12; Bulbus Fritillariae Thunbergii 3 ~ 9;
Flos Chrysanthemi Indici 6 ~ 15; Caulis Piperis Kadsurae 6 ~ 12; Cortex Acanthopancis 4 ~ 9;
Radix Schefflerae Arboricolae 0 ~ 30; Fructus Mori 0 ~ 15; Flos Carthami 0 ~ 9;
The Radix Astragali 0 ~ 25; Radix Adenophorae 0 ~ 9; Radix Notoginseng 0 ~ 9;
Ramulus Cinnamomi 0 ~ 9.
In the pharmaceutical composition of above-described treatment gouty arthritis, the preferred weight proportioning of each raw material of Chinese medicine of basic side is: Herba Artemisiae Anomalae 6 ~ 10; Cortex Fraxini 6 ~ 12; Bulbus Fritillariae Thunbergii 3 ~ 9;
Flos Chrysanthemi Indici 6 ~ 15; Caulis Piperis Kadsurae 6 ~ 12; Cortex Acanthopancis 4 ~ 9.
The preferred weight proportioning of each raw material of Chinese medicine of optional raw material is:
Radix Schefflerae Arboricolae 0.1 ~ 30; Fructus Mori 0.1 ~ 15; Flos Carthami 0.1 ~ 9;
The Radix Astragali 0.1 ~ 25; Radix Adenophorae 0.1 ~ 9; Radix Notoginseng 0.1 ~ 9;
Ramulus Cinnamomi 0.1 ~ 9.
In the pharmaceutical composition of above-mentioned treatment gouty arthritis, described Herba Artemisiae Anomalae is preferably Artemisia anomah S. Moore (Artemisia anomala), also can be siphonostegia chinensis (Siphonostegia chinensis).
Pharmaceutical composition of the present invention can conventionally in conventional method be prepared, extract the active ingredient of each raw material of Chinese medicine, add required pharmaceutic adjuvant, make the medicine of the oral or exterior-applied formulation of clinical any one applicatory.Pharmaceutical composition of the present invention is prepared preferably by the inventive method of the following stated.Drug combination preparation of the present invention or can be the medicament of the oral or exterior-applied formulation of acceptable any one clinically by the preparation that the inventive method obtains, its dosage form includes but not limited to capsule, soft capsule, tablet, pill, drop pill, granule, powder, patch, unguentum, gel, liquid preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can be prepared by following method, and its step is as follows:
(1) get whole raw material of Chinese medicine by weight ratio to carry out decocting and obtain Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant;
(2) oral or external preparation is made after Aqueous extracts or precipitate with ethanol supernatant concentration; Or, after water intaking extract or precipitate with ethanol supernatant concentration, make oral or external preparation through drying.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, make oral or external preparation after alcohol extract is concentrated, or make oral or external preparation through drying after concentrating; Or get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, make oral or external preparation, or drying makes oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, gets whole raw material of Chinese medicine by weight ratio and carries out alcohol extraction, and alcohol extract concentrates; Medicinal residues decocting, Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) above-mentioned alcohol extraction concentrated solution is merged, add volatile oil, make oral or external preparation; Or above-mentioned alcohol extraction concentrated solution is merged, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge decocting with residue raw material of Chinese medicine, and Aqueous extracts concentrates to obtain water extracting liquid; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract;
(3) medicinal residues decocting, after Aqueous extracts is concentrated, merges with alcohol extract and volatile oil, makes oral or external preparation; Or Aqueous extracts is concentrated, merges with alcohol extract, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) remain raw material of Chinese medicine alcohol extraction together, alcohol extract concentrates;
(3) medicinal residues after above-mentioned alcohol extraction are merged water extraction, Aqueous extracts concentrates;
(4) above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) medicinal residues after above-mentioned alcohol extraction are merged water extraction, Aqueous extracts concentrates;
(4) above-mentioned alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(3) remain raw material of Chinese medicine and merge alcohol extraction, alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) remain raw material of Chinese medicine alcohol extraction, alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can be prepared by following method: get whole raw material of Chinese medicine by weight ratio and pulverize, make oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) remain raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mix, drying makes oral or external preparation; Or get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, mix with Bulbus Fritillariae Thunbergii or Radix Notoginseng or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder, drying makes oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Residue raw material of Chinese medicine carries out decocting and obtains Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains water extract-alcohol precipitation supernatant;
(2) mix with Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder after Aqueous extracts or water extract-alcohol precipitation supernatant concentration, drying makes oral or external preparation.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Fructus Mori, residue Radix Notoginseng 2 taste or the Radix Astragali, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori, residue Radix Notoginseng 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(4) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(5), by water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, oral or external preparation is made.
The pharmaceutical composition for the treatment of gouty arthritis of the present invention can also be prepared by following method, and its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(4), by above-mentioned alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, oral or external preparation is made.
In above-described preparation method technical scheme, the w/v, extraction time, extraction time etc. of the water that water extraction or alcohol extraction add or ethanol and raw material can with reference to common process.
It is below the drug action experiment that inventor does.
One, Experimental agents:
1, M1: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, weight proportion is 6: 6: 4.5: 6: 6: 9;
2, M2: prescription is, the Radix Astragali, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Ramulus Cinnamomi, weight proportion is 16: 6: 6: 4.5: 6: 6: 6: 3;
3, M3: prescription is, Radix Schefflerae Arboricolae, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Radix Notoginseng, Cortex Acanthopancis, weight proportion is 30: 6: 6: 4.5: 6: 6: 6: 6;
4, M4: prescription is, the Radix Astragali, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, Flos Carthami, weight proportion is 12: 6: 6: 4.5: 6: 6: 6: 6: 6;
5, M5: prescription is, the Radix Astragali, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, Flos Carthami, Radix Adenophorae, Radix Schefflerae Arboricolae, Radix Notoginseng, Ramulus Cinnamomi, weight proportion is 12: 6: 6: 4.5: 6: 6: 6: 6: 6: 6: 6: 6: 3;
6, M6: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, weight proportion is 6: 6: 4.5: 6: 6: 9: 6;
7, M7: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, the Radix Astragali, weight proportion is 6: 6: 4.5: 6: 6: 9: 6: 9;
8, M8: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, Flos Carthami, weight proportion is 6: 6: 4.5: 6: 6: 9: 6: 6;
9, M9: prescription is, Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Cortex Acanthopancis, Fructus Mori, Radix Notoginseng, Radix Schefflerae Arboricolae, weight proportion is 6: 6: 4.5: 6: 6: 9: 6: 6: 30;
Two, experimentation and result.
1, M1 ~ M9 is to the Effect study of hyperuricemia model.
1.1M1 ~ M9 causes the impact of chicken gout model to high protein, high calcium diet.
Modeling: feed with high nucleoprotein, high calcium modeling feedstuff before 100 ages in days are laid eggs, every chicken controls inflow 100ml every day.About 7d laying hen occurs that gout shows, visible lassitude, feather pine disorderly comes off, like crouch, loss of appetite or go on a hunger strike, become thin gradually weak, loose and watery stool is white, containing a large amount of white urate, arthroncus is normal 1 ~ 1.5 times, gently pinches joint softness, wail of dodging, limping pain, astasia etc.Venous blood samples, separation of serum, measures blood uric acid by test kit regulation detection method, and display blood uric acid compared with normal matched group significantly raises, and represents chicken gout disease animal model modeling success.
Get laying hen 80, capture 6 at random as Normal group (namely blank group) by body weight, give conventional feed.All the other are modeling as stated above.Modeling 7d measures blood uric acid, and the laying hen (66) blood uric acid being greater than 80mg/l is Gout Model, is divided into 11 groups at random, often organizes 6, is respectively model group (equal-volume distilled water gavage every day); Allopurinol group (0.018g/kg), M1 ~ M9 group, all with gastric infusion, every day 1 time, successive administration 2 weeks.Period, single cage was raised, and continued feed modeling feedstuff, got blood after last administration, measure serum uric acid value.Chicken uric acid level relatively, result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 1.
Table 1.M1 ~ M9 causes the impact (x ± s) of chicken hyperuricemia on high protein, high calcium diet
* represents that P < 0.01, △ △ represents P < 0.01 compared with model group compared with blank group
Result shows: compared with blank group, and after the modeling of model group chicken, 7d serum uric acid obviously raises (P < 0.01), and chicken metabolic arthritis model modeling success is described.Continuous treatment is after two weeks, and positive controls and each treatment group chicken serum uric acid content all have remarkable reduction (P < 0.01) compared with model group.Illustrate that medicine M1 ~ M9 group all has the effect that can suppress to continue to give high protein, high calcium feedstuff causes chicken uric acid level to raise.
1.2M1 ~ M9 combines on hypoxanthine, Oteracil Potassium the impact causing Studies on Animal Models of Hyperuricemic Mice.
Introduce ICR mice, a point cage adaptability raises 3, freely drinks water, raises with laboratory animal mixed feed, room temperature 20 ~ 25 DEG C, humidity 40 ~ 70%.Get ICR mice 130, female half and half, body weight 18 ~ 22g.Be divided into 13 groups at random, male and female half and half, often organize 10.Be respectively: blank group, model group, M1 ~ M9 group and positive control I, II group.Wherein M1 ~ 9 group respectively gavage give the medicine distillation aqueous suspension of (4.9g, 7.0g, 9.2g, 7.6g, 10.3g, 5.7g, 6.9g, 6.5g, 10.3g crude drug/kg), positive control I group gives the allopurinol of 39mg/kg, positive control II group gives the benzbromarone of 6.5mg/kg, and model group gives isometric distilled water.Once a day, administration 10 days are total to.1h after last administration, respectively organizes mouse peritoneal injection hypoxanthine 1g/kg, subcutaneous injection Oteracil Potassium 0.1g/kg except blank group.Blank group mouse peritoneal the isometric normal saline of subcutaneous injection.1h after injection, each group mouse orbit gets blood, conventional separation of serum, measures uric acid in serum level, and result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 2.
Table 2.M1 ~ M9 combines on hypoxanthine, Oteracil Potassium the impact (x ± s) causing mouse hyperuricemia
* represents that P < 0.01, △ △ represents P < 0.01 compared with model group compared with blank group
Result shows: compared with blank group, and after the modeling of model group mice, 1h serum uric acid obviously raises (P < 0.01), and acute metabolic arthritis model modeling success is described.Positive controls and each treatment group mice serum uric acid content all have remarkable reduction (P < 0.01) compared with model group.Illustrate medicine M1 ~ M9 group all have can suppress hypoxanthine, Oteracil Potassium combines the effect causing metabolic arthritis model mice uric acid and increase.
1.3M1 ~ M9 combines on hypoxanthine, Oteracil Potassium the impact causing rat hyperuricemia model.
Introduce Wistar rat, sub-cage rearing, freely drinks water, and raises with laboratory animal mixed feed, keeps room temperature 20 ~ 25 DEG C, humidity 40 ~ 70%.Get Wistar rat 130, female half and half, body weight 180 ~ 220g.Be divided into 13 groups at random, male and female half and half, often organize 10.Be respectively: blank group, model group, M1 ~ M9 group and positive control I, II group.Wherein M1 ~ 9 group respectively gavage give (3.4g, 4.8,6.3,5.3g, 7.2g, 3.9g, 4.7g, 4.4g, 7.2g crude drug/kg) medicine distillation aqueous suspension, positive control I group gives the allopurinol of 19.5mg/kg, positive control II group gives the benzbromarone of 3.3mg/kg, and model group gives isometric distilled water.Once a day, administration 10 days are total to.Often organize every rat eye socket after one hour in last administration and get blood, conventional separation of serum, measure uric acid in serum (UA) and xanthine oxidase (XOD) content.The one factor analysis of variance of data acquisition SPSS 13.0 is added up.The results are shown in Table 3.
Table 3M1 ~ M9 combines on hypoxanthine, Oteracil Potassium the impact (x ± s) causing rat hyperuricemia model serum UA content and XOD level
* represents P < 0.01 compared with blank group, * P < 0.05 compared with blank group is represented, △ △ represents that P < 0.01, △ represents P < 0.05 compared with model group compared with model group
Result shows: all there were significant differences compared with blank group for model group rats serum UA with XOD (P < 0.01, P < 0.05).Each treatment group all can reduce serum UA content (P < 0.01) in various degree compared with model group.M1 ~ M9 each treatment group serum XOD level all declines (P < 0.05) compared with model group.Illustrate that medicine M1 ~ M9 has suppression hypoxanthine, Oteracil Potassium combines the effect causing rat hyperuricemia model serum uric acid and increase, the part mechanism that medicine plays a role may be that the activity by reducing XOD realizes.
2, M1 ~ M9 analgesic activity research.
2.1M1 ~ M9 causes the impact of mice vola pain to hot plate.
The Female ICR mice of body weight 18 ~ 22g, a point cage adaptability raises 3, freely drinks water, raises with laboratory animal mixed feed, room temperature 20 ~ 25 DEG C, humidity 40 ~ 70%.Before experiment, the mice of the screening threshold of pain in 5 ~ 30 seconds is used for experiment.The qualified mice of screening is divided into 11 groups at random, often organizes 20.Namely blank group, M1 ~ M9 group and positive controls.Wherein M1 ~ 9 group respectively gavage give the medicine distillation aqueous suspension of (4.9g, 7.0g, 9.2g, 7.6g, 10.3g, 5.7g, 6.9g, 6.5g, 10.3g crude drug/kg), positive controls gives notoginseng injury tablet, and blank group gives isometric distilled water.Each group of mouse stomach gives test medicine 20ml/kg body weight, once a day, and administration 3 days.
1h after last administration, is placed on the metallic plate of preheating 52 DEG C, constant temperature by mice, lick the incubation period of metapedes reaction as threshold of pain index using mice.Result adopts the one factor analysis of variance of SPSS 13.0 to add up.Difference between more each group.The results are shown in Table 4.
Table 4.M1 ~ M9 causes the impact (x ± s) of mice vola pain on hot plate
* represents P < 0.01 compared with blank group
Result shows: medicine M1 ~ M9 group all can significantly improve the pain threshold of mice, and the incubation period that mice licks metapedes reaction on the metallic plate of 52 DEG C is compared with model group, has significant significant difference (P < 0.01).Illustrate that medicine M1 ~ M9 group all has the effect that stronger heat resistanceheat resistant plate causes mice vola pain.
2.2M1 ~ M9 Dichlorodiphenyl Acetate causes the impact of mouse writhing pain.
The ICR mice of body weight 18 ~ 22g, a point cage adaptability raises 3, freely drinks water, raises with laboratory animal mixed feed, room temperature 20 ~ 23 DEG C, humidity 50 ~ 70%.Be divided into 11 groups at random, often organize 20.Namely blank group, M1 ~ M9 and positive controls.Wherein M1 ~ 9 group respectively gavage give the medicine distillation aqueous suspension of (4.9g, 7.0g, 9.2g, 7.6g, 10.3g, 5.7g, 6.9g, 6.5g, 10.3g crude drug/kg), positive controls gives aspirin 0.2g/kg, and blank group gives isometric distilled water.Each group of mouse stomach gives test medicine 20ml/kg body weight, once a day, and administration 3 days.
1h after last administration, last administration 1h pneumoretroperitoneum only injects 0.6% acetic acid normal saline solution 0.2ml/, writhing number of times in observed and recorded every mice 30min.Result adopts the one factor analysis of variance of SPSS 13.0 to add up.Difference between more each group.The results are shown in Table 5.
Table 5.M1 ~ M9 Dichlorodiphenyl Acetate causes the impact (x ± s) of mouse writhing pain
* represents P < 0.01 compared with blank group
Result shows: medicine M1 ~ M9 group all significantly can reduce the mouse writhing number of times of acetic-acid induced, and writhing number of times is compared with model group, has significant significant difference (P < 0.01).Illustrate that medicine M1 ~ M9 group all has the effect that stronger anti-acetic acid causes mouse writhing pain.
3, M1 ~ M9 anti-inflammatory effect research.
3.1M1 ~ M9 is on the impact of mouse peritoneal permeability
Get ICR mice 110, male, body weight 18 ~ 22g.The equal sub-cage rearing of mice, freely drinks water, and raises with laboratory animal mixed feed, keeps room temperature 20 ~ 25 DEG C, humidity 40 ~ 70%.Mice adaptability starts test after feeding three.Be divided into 11 groups at random, often organize 10.Be respectively: namely blank group, M1 ~ M9 and positive controls.Wherein M1 ~ 9 group respectively gavage give the medicine distillation aqueous suspension of (4.9g, 7.0g, 9.2g, 7.6g, 10.3g, 5.7g, 6.9g, 6.5g, 10.3g crude drug/kg), positive controls gives aspirin 0.2g/kg, and blank group gives isometric distilled water.Each group of mouse stomach gives test medicine 20ml/kg body weight, once a day, and successive administration 3 days.
30min after last administration, each group of mouse mainline 0.5% azovan blue normal saline solution 0.1ml/10g, lumbar injection 0.6% acetic acid 0.2ml/ only immediately, put to death after 20min, immediately abdominal cut integumentary musculature, with 5ml brine abdominal cavity, sucking-off cleaning mixture, 3000 leave heart 15min, get supernatant and dilute one times, in each sample cell absorbance of 590nm colorimetric determination.Result adopts the one factor analysis of variance of SPSS 13.0 to add up.The results are shown in Table 6.
Table 6M1 ~ M9 Dichlorodiphenyl Acetate causes the impact (x ± s) that mouse peritoneal capillary permeability increases
* represent that P < 0.05, * * represents P < 0.01 compared with model group compared with model group
Result shows, each treatment group OD value compared with model group all reduces significantly (P < 0.05).Illustrate that M1 ~ M9 all has good anti-acetic acid to cause the effect of mouse peritoneal capillary permeability increase.
Inventor by going deep into systematic study, filter out can antalgic and inflammation relieving, the Chinese medicine basic recipe of blood uric acid can be reduced again, namely form substantially square by Herba Artemisiae Anomalae, Cortex Fraxini, Bulbus Fritillariae Thunbergii, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae and Cortex Acanthopancis 6 taste raw material; One or more raw materials added in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng and Ramulus Cinnamomi 7 taste raw material also can be selected to carry out prescription.Compared with prior art, pharmaceutical composition of the present invention has good safety, can remarkable antalgic and inflammation relieving, effective reduction serum Uric Acid Concentration, obviously improve each phase symptom of gout, be applicable to treat gout, hyperuricemia, be particularly useful for treating gouty arthritis.
Detailed description of the invention
Below further describe concrete technical scheme of the present invention, so that those skilled in the art understands the present invention further, and do not form the restriction to its right.
Embodiment 1.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 0.1; Cortex Fraxini 0.1; Bulbus Fritillariae Thunbergii 0.1; Flos Chrysanthemi Indici 0.1; Caulis Piperis Kadsurae 0.1; Cortex Acanthopancis 0.1.Technology extracts the active ingredient of each raw material routinely, adds conventional pharmaceutical adjuvants, makes oral or external preparation.
Embodiment 2.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 15; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 15.Its preparation method gets whole raw material of Chinese medicine by weight ratio to pulverize, and makes powder or honeyed pill.
Embodiment 3.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 0.1; Cortex Fraxini 0.1; Bulbus Fritillariae Thunbergii 0.1; Flos Chrysanthemi Indici 15; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 15.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and obtain Aqueous extracts; Mixture is made after Aqueous extracts is concentrated; Or make granule through drying after Aqueous extracts is concentrated.
Embodiment 4.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 4.5; Flos Chrysanthemi Indici 6; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 9.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and obtain Aqueous extracts, and precipitate with ethanol after Aqueous extracts is concentrated, obtains precipitate with ethanol supernatant; Oral liquid is made after precipitate with ethanol supernatant concentration; Or make capsule through drying after getting precipitate with ethanol supernatant concentration.
Embodiment 5.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 9; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 9.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, makes oral or external preparation, or make external preparation through drying after concentrating after alcohol extract is concentrated.
Embodiment 6.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 0.1; Caulis Piperis Kadsurae 0.1; Cortex Acanthopancis 0.1.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 7.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 12; Caulis Piperis Kadsurae 1; Cortex Acanthopancis 12.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, makes oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 8.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7.5; Cortex Fraxini 7.5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 7.5; Caulis Piperis Kadsurae 7.5; Cortex Acanthopancis 4.5.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, make soft capsule, or drying makes capsule.
Embodiment 9.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 8; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 6; In Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi arbitrarily simply 8.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out decocting and obtain Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant; Oral or external preparation is made after Aqueous extracts or precipitate with ethanol supernatant concentration; Or, after water intaking extract or precipitate with ethanol supernatant concentration, make oral or external preparation through drying.
Embodiment 10.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 10; Flos Chrysanthemi Indici 15; Caulis Piperis Kadsurae 8; Cortex Acanthopancis 3; In Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi arbitrarily simply 15.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, makes oral or external preparation, or make oral or external preparation through drying after concentrating after alcohol extract is concentrated; Or get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, make oral or external preparation, or drying makes oral or external preparation.
Embodiment 11.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; In Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi arbitrarily simply 1.Its preparation method is: get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 12.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 4.5; Flos Chrysanthemi Indici 6; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 6; The Radix Astragali 16; Ramulus Cinnamomi 2.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral tablet.
Embodiment 13.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7.1; Cortex Fraxini 7.3; Bulbus Fritillariae Thunbergii 5.5; Flos Chrysanthemi Indici 7.8; Caulis Piperis Kadsurae 8.6; Cortex Acanthopancis 14; The Radix Astragali 30.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned alcohol extraction concentrated solution is merged, adds volatile oil, make oral or external preparation; Or above-mentioned alcohol extraction concentrated solution is merged, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 14.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 9; Cortex Acanthopancis 8; Ramulus Cinnamomi 1.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, and alcohol extract concentrates; Medicinal residues decocting, Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make pill.
Embodiment 15.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 9; Fructus Mori 5.Its preparation method is: get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extract volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 16.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 7; Flos Chrysanthemi Indici 8; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 9; Radix Schefflerae Arboricolae 30.Its preparation method is: get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 17.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 4.5; Flos Chrysanthemi Indici 6; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 6; Radix Notoginseng 6; Radix Schefflerae Arboricolae 30.Its preparation method is: get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 18.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 5; Radix Notoginseng 5; Radix Schefflerae Arboricolae 25; Fructus Mori 5.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes soft capsule; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make drop pill.
Embodiment 19.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 5; Radix Notoginseng 3; Radix Schefflerae Arboricolae 5; Ramulus Cinnamomi 5.Its preparation method is: get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Residue raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mix, drying makes oral or external preparation; Or get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, mix with Bulbus Fritillariae Thunbergii or Radix Notoginseng or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder, drying makes oral or external preparation.
Embodiment 20.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 5; The Radix Astragali 10; Fructus Mori 5; Flos Carthami 5.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste, and alcohol extract concentrates; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned alcohol extraction concentrated solution is merged, makes oral or external preparation; Or alcohol extraction concentrated solution is merged dry, make oral or external preparation.
Embodiment 21.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 7; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 6; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 6; Radix Notoginseng 6; Fructus Mori 6.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 22.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 14; Cortex Fraxini 13; Bulbus Fritillariae Thunbergii 12; Flos Chrysanthemi Indici 20; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 9; Radix Adenophorae 9.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge decocting with residue raw material of Chinese medicine, and Aqueous extracts concentrates to obtain water extracting liquid; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution; Get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make unguentum; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make patch.
Embodiment 23.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 4; Radix Adenophorae 6; Fructus Mori 4.Its preparation method is: get that Bulbus Fritillariae Thunbergii is all or part of beats powder by weight ratio; Get Fructus Mori 1 taste water extraction by weight ratio, Aqueous extracts concentrates to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; By water extracting liquid or the mixing of water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder, dry, after adding enclose or the volatile oil of non-enclose, make capsule.
Embodiment 24.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 5; Flos Carthami 6.Its preparation method is: get that Bulbus Fritillariae Thunbergii is all or part of beats powder by weight ratio; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; By above-mentioned alcohol extraction concentrated solution and the mixing of Bulbus Fritillariae Thunbergii powder, dry, after adding enclose or the volatile oil of non-enclose, make patch.
Embodiment 25.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 3; Cortex Acanthopancis 3; Flos Carthami 3; The Radix Astragali 6.Its preparation method is: get Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste extracts volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine, and Aqueous extracts concentrates to obtain water extracting liquid; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution; Get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 26.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 20; Caulis Piperis Kadsurae 9; Cortex Acanthopancis 9; Radix Schefflerae Arboricolae 20; Fructus Mori 9.Its preparation method is: get Bulbus Fritillariae Thunbergii alcohol extraction by weight ratio, and alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 27.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 2; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 2; Caulis Piperis Kadsurae 2; Cortex Acanthopancis 3; Radix Schefflerae Arboricolae 6; Fructus Mori 3; Flos Carthami 2; The Radix Astragali 3; Radix Adenophorae 2; Radix Notoginseng 2; Ramulus Cinnamomi 0.2.Its preparation method is: get Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng is all or part of beats powder, and residue raw material of Chinese medicine carries out decocting and obtains Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains water extract-alcohol precipitation supernatant; Mix with Bulbus Fritillariae Thunbergii, Radix Notoginseng powder after Aqueous extracts or water extract-alcohol precipitation supernatant concentration, drying makes oral or external preparation.
Embodiment 28.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 8; Fructus Mori 4.Its preparation method is: get Bulbus Fritillariae Thunbergii alcohol extraction by weight ratio, and alcohol extract concentrates; Get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, makes oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 29.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Fructus Mori 4; The Radix Astragali 8.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral or external preparation; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 30.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 3; Cortex Acanthopancis 6; Fructus Mori 3; The Radix Astragali 6; Ramulus Cinnamomi 2.Its preparation method is: get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, after Aqueous extracts is concentrated, merges with alcohol extract and volatile oil, makes oral or external preparation; Or Aqueous extracts is concentrated, merges with alcohol extract, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 31.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 3; Cortex Acanthopancis 3; Flos Carthami 3; Radix Schefflerae Arboricolae 9.Its preparation method is: get Radix Schefflerae Arboricolae water extraction by weight ratio, and Aqueous extracts concentrates to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici by weight ratio, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract is concentrated; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 32.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Fructus Mori 4; The Radix Astragali 6; Ramulus Cinnamomi 0.3.Its preparation method is: get Bulbus Fritillariae Thunbergii alcohol extraction by weight ratio, and alcohol extract concentrates; Get Fructus Mori, Radix Astragali water extraction by weight ratio, Aqueous extracts concentrates to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 33.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Fructus Mori 4; Radix Notoginseng 4; Radix Schefflerae Arboricolae 25.Its preparation method is: get Radix Schefflerae Arboricolae 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
Embodiment 34.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Fructus Mori 3; Radix Notoginseng 4; Radix Schefflerae Arboricolae 30.Its preparation method is: get Radix Schefflerae Arboricolae 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
Embodiment 35.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Radix Notoginseng 4; Radix Schefflerae Arboricolae 30.Its preparation method is: get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Residue raw material of Chinese medicine carries out decocting and obtains Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains water extract-alcohol precipitation supernatant; Mix with Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder after Aqueous extracts or water extract-alcohol precipitation supernatant concentration, drying makes capsule.
Embodiment 36.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 2; Cortex Acanthopancis 2; Fructus Mori 1; Radix Notoginseng 2; Radix Schefflerae Arboricolae 10; Radix Adenophorae 1; Flos Carthami 1.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and pulverize, make oral or external preparation.
Embodiment 37.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 5; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 7; Fructus Mori 5; Flos Carthami 5.Its preparation method is: get Fructus Mori water extraction by weight ratio, and Aqueous extracts concentrates to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Bulbus Fritillariae Thunbergii alcohol extraction by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 38.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 4; Bulbus Fritillariae Thunbergii 2; Flos Chrysanthemi Indici 4; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 6; Fructus Mori 4; The Radix Astragali 6; Flos Carthami 4.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates; Get Fructus Mori 1 taste or the Radix Astragali 1 taste or Fructus Mori, the Radix Astragali 2 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extracting liquid, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 39.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 3; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 3; Caulis Piperis Kadsurae 3; Cortex Acanthopancis 6; Fructus Mori 3; The Radix Astragali 6; Flos Carthami 3; Radix Adenophorae 3.Its preparation method is: get Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae extraction volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, after Aqueous extracts is concentrated, merges with alcohol extract and volatile oil, makes oral or external preparation; Or Aqueous extracts is concentrated, merges with alcohol extract, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 40.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 4; Cortex Fraxini 6; Bulbus Fritillariae Thunbergii 4; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 4; Cortex Acanthopancis 9; Fructus Mori 4; The Radix Astragali 6; Flos Carthami 3; Ramulus Cinnamomi 0.3.Its preparation method is: get Bulbus Fritillariae Thunbergii alcohol extraction by weight ratio, and alcohol extract concentrates; Get Fructus Mori 4 by weight ratio; The Radix Astragali 2 taste water extraction, precipitate with ethanol after Aqueous extracts is concentrated, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste extraction volatile oil by weight ratio, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 41.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 2; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 2; Caulis Piperis Kadsurae 1; Cortex Acanthopancis 2; Any two tastes each 1 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, and alcohol extract concentrates; Medicinal residues decocting, Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 42.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any two tastes each 15 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned alcohol extraction concentrated solution is merged, adds volatile oil, make oral or external preparation; Or above-mentioned alcohol extraction concentrated solution is merged, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 43.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 5; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 10; Any two tastes each 10 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil; Medicinal residues merge decocting with residue raw material of Chinese medicine, and Aqueous extracts concentrates to obtain water extracting liquid; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution; Get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 44.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 7; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 8; Caulis Piperis Kadsurae 11; Cortex Acanthopancis 6; Any three tastes each 6 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil; Medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract; Medicinal residues decocting, after Aqueous extracts is concentrated, merges with alcohol extract and volatile oil, makes oral or external preparation; Or Aqueous extracts is concentrated, merges with alcohol extract, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 45.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any three tastes each 15 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; The alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral or external preparation; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral or external preparation.
Embodiment 46.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 1; Cortex Acanthopancis 1; Any three tastes each 1 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Medicinal residues after above-mentioned alcohol extraction are merged water extraction, and Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, makes oral or external preparation; Or, alcohol extraction concentrated solution, water extracting liquid is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 47.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any four tastes each 5 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 48.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 5; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 2; Caulis Piperis Kadsurae 5; Cortex Acanthopancis 8; Any four tastes each 15 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, and alcohol extract concentrates; Get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 49.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 6; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 9; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 9; Any four tastes each 9 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates; Residue raw material of Chinese medicine merges alcohol extraction, and alcohol extract concentrates; Above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
Embodiment 50.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 3; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 1; Flos Chrysanthemi Indici 6; Caulis Piperis Kadsurae 6; Cortex Acanthopancis 9; Any four tastes each 3 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; The alcohol extraction of residue raw material of Chinese medicine, alcohol extract concentrates; Water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, makes oral or external preparation; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral or external preparation.
Embodiment 51.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 2; Caulis Piperis Kadsurae 9; Cortex Acanthopancis 7; Any five tastes each 15 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get whole raw material of Chinese medicine by weight ratio and pulverize, make oral or external preparation.
Embodiment 52.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 9; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 10; Any five tastes each 0.1 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: (1) gets Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; (2) remain raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mix, drying makes oral or external preparation; Or get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, mix with Bulbus Fritillariae Thunbergii or Radix Notoginseng or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder, drying makes oral or external preparation.
Embodiment 53.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 13; Bulbus Fritillariae Thunbergii 3; Flos Chrysanthemi Indici 12; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 7; Any five tastes each 8 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Residue raw material of Chinese medicine carries out decocting and obtains Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains water extract-alcohol precipitation supernatant; Mix with Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder after Aqueous extracts or water extract-alcohol precipitation supernatant concentration, drying makes oral or external preparation.
Embodiment 54.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 15; Cortex Fraxini 1; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any five tastes each 5 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Fructus Mori, residue Radix Notoginseng 2 taste or the Radix Astragali, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori, residue Radix Notoginseng 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; By water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 55.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any Six-element each 10 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is: get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates; Get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates; By above-mentioned alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, make oral or external preparation.
Embodiment 56.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 1; Cortex Fraxini 15; Bulbus Fritillariae Thunbergii 15; Flos Chrysanthemi Indici 1; Caulis Piperis Kadsurae 15; Cortex Acanthopancis 1; Any Six-element each 1 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is as embodiment 53.
Embodiment 57.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 9; Caulis Piperis Kadsurae 9; Cortex Acanthopancis 1; Any Six-element each 15 in Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng or Ramulus Cinnamomi.Its preparation method is as embodiment 54.
Embodiment 58.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 2; Cortex Fraxini 10; Bulbus Fritillariae Thunbergii 5; Flos Chrysanthemi Indici 9; Caulis Piperis Kadsurae 9; Cortex Acanthopancis 1; Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng and Ramulus Cinnamomi each 5.Its preparation method is as embodiment 50.
Embodiment 59.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 8; Cortex Fraxini 8; Bulbus Fritillariae Thunbergii 6; Flos Chrysanthemi Indici 10; Caulis Piperis Kadsurae 10; Cortex Acanthopancis 6; Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng and Ramulus Cinnamomi each 10.Its preparation method is as embodiment 54.
Embodiment 60.Treat a pharmaceutical composition for gouty arthritis, it is made up of the raw material of Chinese medicine of following weight proportion, Herba Artemisiae Anomalae 9; Cortex Fraxini 12; Bulbus Fritillariae Thunbergii 8; Flos Chrysanthemi Indici 14; Caulis Piperis Kadsurae 3; Cortex Acanthopancis 12; Radix Schefflerae Arboricolae, Fructus Mori, Flos Carthami, the Radix Astragali, Radix Adenophorae, Radix Notoginseng and Ramulus Cinnamomi each 15.Its preparation method is as embodiment 54.

Claims (21)

1. treat a pharmaceutical composition for gouty arthritis, it is characterized in that, it is the oral formulations be made up of the raw material of Chinese medicine of following weight proportion,
2. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get whole raw material of Chinese medicine by weight ratio to carry out decocting and obtain Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains precipitate with ethanol supernatant;
(2) oral formulations is made after Aqueous extracts or precipitate with ethanol supernatant concentration; Or, after water intaking extract or precipitate with ethanol supernatant concentration, make oral formulations through drying.
3. treat the preparation method of the pharmaceutical composition of gouty arthritis as claimed in claim 1 for one kind, it is characterized in that, get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, make oral formulations after alcohol extract is concentrated, or make oral formulations through drying after concentrating; Or get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, make oral formulations, or drying makes oral formulations.
4. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates, and adds volatile oil, makes oral formulations; Or by alcohol extract concentrate drying, after adding enclose or the volatile oil of non-enclose, make oral formulations.
5. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, get whole raw material of Chinese medicine by weight ratio and carry out alcohol extraction, alcohol extract concentrates; Medicinal residues decocting, Aqueous extracts concentrates; Above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, makes oral formulations; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral formulations.
6. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) above-mentioned alcohol extraction concentrated solution is merged, add volatile oil, make oral formulations; Or above-mentioned alcohol extraction concentrated solution is merged, dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
7. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge decocting with residue raw material of Chinese medicine, and Aqueous extracts concentrates to obtain water extracting liquid; Or, water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration obtains water extract-alcohol precipitation concentrated solution;
(3) get water extracting liquid or water extract-alcohol precipitation concentrated solution, add volatile oil, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
8. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil;
(2) medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract reclaims ethanol, obtains alcohol extract;
(3) medicinal residues decocting, after Aqueous extracts is concentrated, merges with alcohol extract and volatile oil, makes oral formulations; Or Aqueous extracts is concentrated, merges with alcohol extract, dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
9. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) remain raw material of Chinese medicine alcohol extraction together, alcohol extract concentrates;
(3) medicinal residues after above-mentioned alcohol extraction are merged water extraction, Aqueous extracts concentrates;
(4) above-mentioned alcohol extraction concentrated solution, water extracting liquid are merged, make oral formulations; Or, by alcohol extraction concentrated solution, water extracting liquid drying, make oral formulations.
10. a preparation method for the pharmaceutical composition for the treatment of gouty arthritis as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) medicinal residues after above-mentioned alcohol extraction are merged water extraction, Aqueous extracts concentrates;
(4) above-mentioned alcohol extraction concentrated solution, water extracting liquid and volatile oil are merged, make oral formulations; Or, alcohol extraction concentrated solution, water extracting liquid is dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
The preparation method of the pharmaceutical composition of 11. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
The preparation method of the pharmaceutical composition of 12. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(2) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and volatile oil are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, after adding enclose or the volatile oil of non-enclose, make oral formulations.
The preparation method of the pharmaceutical composition of 13. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) get the alcohol extraction of Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(3) remain raw material of Chinese medicine and merge alcohol extraction, alcohol extract concentrates;
(4) above-mentioned water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral formulations.
The preparation method of the pharmaceutical composition of 14. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori 2 taste or Radix Notoginseng, Fructus Mori 2 taste or Radix Notoginseng, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, Radix Notoginseng 3 taste or Radix Notoginseng, Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(2) remain raw material of Chinese medicine alcohol extraction, alcohol extract concentrates;
(3) water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution are merged, make oral formulations; Or, water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution is dry, make oral formulations.
The preparation method of the pharmaceutical composition of 15. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, is characterized in that, get whole raw material of Chinese medicine by weight ratio and pulverize, make oral formulations.
The preparation method of the pharmaceutical composition of 16. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) remain raw material of Chinese medicine alcohol extraction together, after alcohol extract is concentrated and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mix, drying makes oral formulations; Or get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates, the alcohol extraction together of residue raw material of Chinese medicine, and alcohol extract concentrates, and is merged by alcohol extraction concentrated solution, mix with Bulbus Fritillariae Thunbergii or Radix Notoginseng or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder, drying makes oral formulations.
The preparation method of the pharmaceutical composition of 17. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows:
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder; Residue raw material of Chinese medicine carries out decocting and obtains Aqueous extracts; Or precipitate with ethanol after water intaking extract is concentrated, obtains water extract-alcohol precipitation supernatant;
(2) mix with Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder after Aqueous extracts or water extract-alcohol precipitation supernatant concentration, drying makes oral formulations.
The preparation method of the pharmaceutical composition of 18. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) get Radix Schefflerae Arboricolae 1 taste or the Radix Astragali 1 taste or Fructus Mori 1 taste or Radix Schefflerae Arboricolae, the Radix Astragali 2 taste or Radix Schefflerae Arboricolae, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, Fructus Mori 2 taste or the Radix Astragali, Fructus Mori _ 2 taste or Fructus Mori, residue Radix Notoginseng 2 taste or the Radix Astragali, residue Radix Notoginseng 2 taste or Radix Schefflerae Arboricolae, the Radix Astragali, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, Fructus Mori, the Radix Astragali 3 taste or the Radix Astragali, Fructus Mori, residue Radix Notoginseng 3 taste or Radix Schefflerae Arboricolae, the Radix Astragali, Fructus Mori, residue Radix Notoginseng 4 taste water extraction by weight ratio, Aqueous extracts is concentrated to obtain water extracting liquid; Or water extracting liquid precipitate with ethanol, precipitate with ethanol supernatant concentration, obtains water extract-alcohol precipitation concentrated solution;
(3) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(4) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(5), by water extracting liquid or water extract-alcohol precipitation concentrated solution, alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, oral formulations is made.
The preparation method of the pharmaceutical composition of 19. 1 kinds for the treatment of gouty arthritises as claimed in claim 1, it is characterized in that, its step is as follows,
(1) get Bulbus Fritillariae Thunbergii 1 taste or Radix Notoginseng 1 taste or Bulbus Fritillariae Thunbergii by weight ratio, Radix Notoginseng 2 taste is all or part of beats powder;
(2) get the alcohol extraction of residue Bulbus Fritillariae Thunbergii 1 taste by weight ratio, alcohol extract concentrates;
(3) get Flos Chrysanthemi Indici 1 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae 2 taste or Flos Chrysanthemi Indici by weight ratio, Caulis Piperis Kadsurae 2 taste or Flos Chrysanthemi Indici, Ramulus Cinnamomi 2 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae 3 taste or Herba Dendranthematis indici _ flower, Caulis Piperis Kadsurae, Ramulus Cinnamomi 3 taste or Flos Chrysanthemi Indici, Herba Artemisiae Anomalae, Caulis Piperis Kadsurae, Ramulus Cinnamomi 4 taste extract volatile oil, medicinal residues merge alcohol extraction with residue raw material of Chinese medicine, and alcohol extract concentrates;
(4), by above-mentioned alcohol extraction concentrated solution and Bulbus Fritillariae Thunbergii powder or Radix Notoginseng powder or Bulbus Fritillariae Thunbergii, Radix Notoginseng powder mixing, dry, after adding enclose or the volatile oil of non-enclose, oral formulations is made.
20. 1 kinds of preparations obtained as preparation method as described in any one in claim 2-19, it is characterized in that, described preparation is the medicament of acceptable any one peroral dosage form clinically.
21. 1 kinds of pharmaceutical compositions as described in claim 1 are as the purposes of active ingredient in preparation treatment gout, gouty arthritis, antihyperuricemic disease drug.
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