CN101890080B - Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof - Google Patents
Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a hair-loss preventing and hair-restoring medicinal composition and a preparation method thereof, shampoo containing the medicinal composition and a preparation method thereof. The hair-loss preventing and hair-restoring medicinal composition comprises the following components in parts by weight: 1 to 4 parts of ginseng, 5 to 9 parts of lightyellow sophora root, 5 to 9 parts of tuber fleeceflower root, 3 to 6 parts of rhizome of chuanxiong, and 2 to 6 parts of eclipta prostrate. The invention provides the hair-loss preventing and hair-restoring medicinal composition which can prevent hair loss, contribute to hair growth, is safe and reliable without toxic or side effect and the preparation method thereof, as well as the shampoo containing the medicinal composition and the preparation method thereof.
Description
Technical field
The invention belongs to biological chemical field, relate to a kind of hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, contain shampoo of this drug composition and preparation method thereof.
Background technology
Hair loss patient increases and becomes a trend that can not be ignored, except disease, big, the spiritual constant tension of operating pressure, dietary structure imbalance, the irregular unsound life style such as (excessively work overtime, stay up late) of working and resting is to cause the increasing main cause of alopecia crowd.The critical defect of daily use chemicals class product for improving hair-growing is that effect is extremely not obvious even invalid fully for hair growth promoting at present.Reason mainly is to fail to make the hair growth promoting composition to propose and infiltrate through hair follicle cell.The present invention has overcome the defective of the anti-alopecia product of the existing Chinese medicine ingredients in most of market, and the phalacrosis prevention and hair generation effect is obvious.
Summary of the invention
In order to solve the above-mentioned technical problem that exists in the background technology, the invention provides and a kind ofly prevent alopecia, help natural on-off cycles of hair growth, the safe and reliable and hair-loss preventing and hair-restoring medicinal composition that has no side effect and preparation method thereof, contain shampoo of this drug composition and preparation method thereof.
Technical solution of the present invention is: the invention provides a kind of hair-loss preventing and hair-restoring medicinal composition, its special character is: described hair-loss preventing and hair-restoring pharmaceutical composition comprises that weight portion is 1～4 part Radix Ginseng, 5～9 parts Radix Sophorae Flavescentis, 5～9 parts Radix Polygoni Multiflori, 3～6 parts Rhizoma Chuanxiong and 2～6 parts Eclipta prostrata preparation.
Above-mentioned hair-loss preventing and hair-restoring pharmaceutical composition comprises that weight portion is 2～3 parts Radix Ginseng, 6～8 parts Radix Sophorae Flavescentis, 6～8 parts Radix Polygoni Multiflori, 4～5 parts Rhizoma Chuanxiong and 3～5 parts Eclipta prostrata preparation.
A kind of method for preparing the hair-loss preventing and hair-restoring pharmaceutical composition, its special character is: said method comprising the steps of:
1) getting Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong and Eclipta prostrata cleans standby;
2) Radix Ginseng, Radix Polygoni Multiflori and Rhizoma Chuanxiong are carried out alcohol extraction, obtain alcohol extraction clear paste and alcohol extraction medicinal residues, standby;
3) with step 2) resulting alcohol extraction medicinal residues and Radix Sophorae Flavescentis and Eclipta prostrata carry out water and carry, and obtaining water, to carry clear paste standby, and water is carried medicinal residues and is abandoned;
4) the resulting water of step 3) is carried clear paste and carries out precipitate with ethanol, obtain water behind the precipitate with ethanol carry clear paste and with step 2) resulting alcohol extraction clear paste mixes, and obtains the ethanol extract, medicinal residues are standby;
5) medicinal residues that step 4) is obtained carry out the extraction of precipitate with ethanol medicinal residues, obtain the water extract.
Above-mentioned steps 2) specific implementation is:
Get Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Chuanxiong and doubly measure 80% ethanol extraction 1～3 time, collect all filtrates, cross 200 mesh sieves with 7-10, at decompression recycling ethanol below 70～80 ℃, and filtrate is concentrated into the clear paste that density is 1.10-1.35, and obtain alcohol extraction clear paste and alcohol extraction medicinal residues, standby.
Above-mentioned steps 3) specific implementation is:
With step 2) resulting alcohol extraction medicinal residues and Radix Sophorae Flavescentis, Eclipta prostrata carry out water and carry 1～3 time, collects all filtrates, crosses 100 mesh sieves, and it is standby that the water that is concentrated into density and is 1.10-1.35 is carried clear paste, and water is carried medicinal residues and is abandoned.
Above-mentioned steps 4) specific implementation is:
The resulting water of step 3) is carried clear paste carry out precipitate with ethanol, utilize 70% ethanol precipitate with ethanol 18-36 hour, cross 200 mesh sieves, reclaim ethanol, the water that filtrate is concentrated into behind the precipitate with ethanol that density is 1.10-1.35 is carried clear paste, with step 2) resulting alcohol extraction clear paste mixes, obtain the ethanol extract, medicinal residues are standby.
Above-mentioned steps 5) specific implementation is:
5) medicinal residues that step 4) is obtained carry out the extraction of precipitate with ethanol medicinal residues, cross 200 mesh sieves, get pure slag liquid, are concentrated into the clear paste that density is 1.10-1.35, obtain the water extract.
A kind of hair-loss preventing and hair-restoring shampoo that contains the hair-loss preventing and hair-restoring pharmaceutical composition, its special character is: described hair-loss preventing and hair-restoring shampoo comprises that percentage by weight is that the hair-loss preventing and hair-restoring pharmaceutical composition of 5-15%, the cleaning agent of 10-30% and the solvent preparation of 55-70% come.
Above-mentioned solvent is a deionized water.
Above-mentioned cleaning agent is one or more combinations of polyoxyethylenated alcohol sodium sulfate, ammonium lauryl sulfate, coconut oil diethanol amide and dodecylbenzene sodium sulfonate.
Above-mentioned hair-loss preventing and hair-restoring shampoo comprises that also percentage by weight is the hair conditioner of 2-5%, the thickening agent of 0.1-0.6%, the fragrant agent of 0.1-0.5%, the pearling agent of 1-5% and the antiseptic of 0.01-0.1%.
Above-mentioned hair conditioner is a Cortex cocois radicis oleoyl propyl-dimethyl betanin; Described pearling agent is a Pearl Concentrate; Described thickening agent is a cationic guar gum; Described fragrant agent is an essence; Described antiseptic is methylchloroisothiazandnone and Methylisothiazolinone.
A kind of preparation method of hair-loss preventing and hair-restoring shampoo, its special character is: said method comprising the steps of:
1) thickening agent, solvent and hair-loss preventing and hair-restoring pharmaceutical composition are added the homogenizing pot, be heated to 76-85 ℃, stir, kept 10-30 minute;
2) cleaning agent and hair conditioner are joined in the stainless steel cask, be heated to dissolving, treat to add when the homogenizing pot temperature is reduced to 70-75 ℃, stir;
3) treat to add when the homogenizing pot temperature is reduced to 50-55 ℃ pearling agent;
4) treat that the homogenizing pot temperature reduces to 40-45 ℃ and add fragrant agent and antiseptic, stir evacuation 8-15 minute;
5) treat that the homogenizing pot temperature reduces to 35-40 ℃ of discharging, fill was left standstill in sealing 36-80 hour.
Above-mentioned steps 2) mixing speed is 15-25r/min in.
Advantage of the present invention is:
1, can prevent alopecia, help natural on-off cycles of hair growth.Hair-loss preventing and hair-restoring medicinal composition provided by the present invention adopts Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Eclipta prostrata etc. can impel the natural Chinese medicines compatibility of natural on-off cycles of hair growth, be based on effecting a permanent cure, the hair growth promoting of reinforcing the kidney, by replenishing QI to invigorate the spleen, liver and kidney tonifying, disperse blood stasis and dredge collateral, make that the human body blood vessels are unimpeded, QI and blood is sufficient, ailment said due to cold or exposure is dispeled, thereby make hair obtain nourishing, reach the purpose of phalacrosis prevention and hair generation.Show by various analysis of experimentss, each raw material in the integral formula provided by the present invention contains a large amount of capillary vessel circulations, antibiotic and strengthen the bioactive ingredients of cell physiological function that improve, can be directly at bonnet wool lens capsule tissue organ, as blood capillary, nervous system, hair papilla etc., play the effect of cleaning, nutrition activation and reparation, thereby reach the effect of phalacrosis prevention and hair generation.
2, safe and reliable, have no side effect.Hair-loss preventing and hair-restoring medicinal composition provided by the present invention is to be raw material with pure Chinese medicine, through scientific matching, be rich in the plant essence that from Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Eclipta prostrata, extracts, nontoxic to human body, without any side effect, life-time service can moisten hair follicle, improves scalp condition, hairy root nourishing, can prevent alopecia, and help natural on-off cycles of hair growth.Simultaneously, the shampoo that contains this pharmaceutical composition provided by the present invention detects proof through the cosmetics inspection mechanism of authorized by state, various physics and chemistry, microbiological indicator all meet the cosmetics health code requirement, and rabbit repeatedly skin irritation reaction integral mean value is 0, belongs to the nonirritant product.Under the 30 second washing conditions, product is microstimulation to the acute eye of rabbit irritant reaction intensity and shows through human trial, the shampoo that contains this pharmaceutical composition provided by the present invention uses as safe as a house reliable to human body whole body and local no any untoward reaction.
The specific embodiment
The invention provides a kind of hair-loss preventing and hair-restoring medicinal composition, this Chinese medicine composition is chosen natural Chinese medicines such as Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Eclipta prostrata and is carried out processing and preparing, and the side of its functional component separates and is:
Radix Ginseng: sweet and slightly bitter taste, temperature is gone into spleen, stomach, lung three warps.Strongly invigorating primordial QI promotes the production of body fluid admittedly take off, and calms the nerves.Control the disease of deficient and all the qi-blood-body fluid deficiencies of impairment caused by overstrain.Modern study is found, multiple beneficial compositions such as kind of saponin, polysaccharide, aminoacid, organic acid and esters, volatile oil and sterol surplus Radix Ginseng contains 30, have the blood circulation of improvement, hemopoietic function, anticoagulant, defying age, adjusting lipid metabolism, antibacterial etc. multiple with promote the relevant function of natural on-off cycles of hair growth.
Radix Sophorae Flavescentis: bitter in the mouth, cold, go into the heart, lung, kidney, large intestine channel.Heat clearing and damp drying, wind dispelling insecticide.Control damp-heat dysentery, discharging fresh blood stool, jaundice, dysuria, edema, leukorrhagia, pudendal pruritus, scabies, skin pruritus, noxious dampness skin infection etc.Radix Sophorae Flavescentis mainly contains multiple alkaloid, as matrine, has functions such as diuresis, antibiotic, antiallergic, is beneficial to natural on-off cycles of hair growth.
Radix Polygoni Multiflori: bitter in the mouth, sweet; Puckery, slightly warm in nature.Go into liver, kidney channel.Nourishing the blood and yin cures mainly soreness of the waist and knees, early whitening of beard and hair of blood deficiency Light-headedness, cardiopalmus, insomnia, the hepatic and renal YIN deficiency etc.Radix Polygoni Multiflori mainly contains compositions such as anthraquinone analog compound, stilbene compound, cupreol, lecithin, have defying age, blood fat reducing, raising periphery lymphocyte DNA damage repair ability, improve non-specific immunity, antibacterial action and the effect of adrenocortical hormone sample of body.These functions have obvious facilitation to natural on-off cycles of hair growth.
Rhizoma Chuanxiong: acrid in the mouth, temperature.Go into liver, gallbladder, pericardium channel.The blood-activating and qi-promoting dissipating depression of QI, dispeiling pathogenic wind and removing dampness.Modern study shows that Rhizoma Chuanxiong has effects such as blood vessel dilating, anticoagulant, antithrombotic formation, releasing spasm.Promote hair growth by improving blood circulation.
Eclipta prostrata: sweet in the mouth, acid, cold.Go into kidney, Liver Channel.Nourishing the liver and kidney, cooling blood for hemostasis.Be used for diseases such as odontoseisis, early whitening of beard and hair, vertigo and tinnitus, the acid of waist knee joint, deficiency of YIN heat in blood, traumatic hemorrhage.Eclipta prostrata is that traditional Chinese medical science crow must hair color, and the key medicine of growth hair is by going into the kidney nourishing YIN hair of growing.Modern study shows that Eclipta prostrata mainly contains materials such as flavone, saponin, polysaccharide, has tangible hemostasis, antibiotic, blood flow increasing and sedation and analgesia effect.These functions are all useful to phalacrosis prevention and hair generation.
Full side selects the drug matching that impels natural on-off cycles of hair growth for use, is based on effecting a permanent cure, and the hair growth promoting of reinforcing the kidney, by replenishing QI to invigorate the spleen, liver and kidney tonifying, disperse blood stasis and dredge collateral makes that the human body blood vessels are unimpeded, QI and blood is sufficient, ailment said due to cold or exposure is dispeled, thereby makes hair obtain nourishing, and reaches the purpose of phalacrosis prevention and hair generation.Modern study also shows, each raw material of filling a prescription contains a large amount of biological activity effective ingredient that improve capillary vessel circulation and mucosa physiological function, can be directly play the effect that cleaning, nutrition activate and repair, thereby reach the effect of phalacrosis prevention and hair generation at bonnet wool lens capsule tissue organ such as blood capillary, nervous system, hair papilla etc.
Hair-loss preventing and hair-restoring medicinal composition provided by the present invention comprises that weight portion is that 1～4 part Radix Ginseng, 5～9 parts Radix Sophorae Flavescentis, 5～9 parts Radix Polygoni Multiflori, 3～6 parts Rhizoma Chuanxiong and 2～6 parts Eclipta prostrata prepare and especially comprise that weight portion is that 2～3 parts Radix Ginseng, 6～8 parts Radix Sophorae Flavescentis, 6～8 parts Radix Polygoni Multiflori, 4～5 parts Rhizoma Chuanxiong and 3～5 parts Eclipta prostrata prepare.
The inventor is through long-term practice, can adopt following any proportioning embodiment, through a large number of experiments show that, this Chinese medicine preparation can reach the effect that is highly profitable, in following table, this weight portion can be gram, kilogram or other unit of weights, no matter be which kind of measurement unit, all can form useful proportioning embodiment:
The preparation method of hair-loss preventing and hair-restoring medicinal composition provided by the present invention is:
1, alcohol extraction: Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Chuanxiong are measured 80% ethanol extractions 2 times with 8 times, 2 hours for the first time, 1.5 hours for the second time (6 times of amount ethanol), merge filtrate twice, filter (crossing 200 mesh sieves), decompression recycling ethanol (below 75 ℃), filtrate is concentrated into the clear paste that density is 1.10-1.35, and is standby.The alcohol extraction medicinal residues are standby.
2, water is carried: alcohol extraction medicinal residues and Radix Sophorae Flavescentis, Eclipta prostrata water carry twice, add 10 times of water gagings for the first time, and 2 hours, add 8 times of water gagings for the second time, 1 hour, merge extracted twice liquid, filter in (100 order), be concentrated into the clear paste that density is 1.10-1.35, medicinal residues are abandoned.
3, precipitate with ethanol: water extraction concentrated solution precipitate with ethanol 24 hours (70% ethanol), filter (crossing 200 mesh sieves), reclaim ethanol, filtrate is concentrated into the clear paste that density is 1.10-1.35.Save as the ethanol extract with 1 alcohol extraction clear paste merging.The precipitate with ethanol medicinal residues are standby.
4, the precipitate with ethanol medicinal residues extract: the precipitate with ethanol medicinal residues add 6 times of water gagings, decoct 20 minutes, filter (crossing 200 mesh sieves), get pure slag liquid (water liquid), are concentrated into the clear paste that density is 1.10-1.35, are the water extract.
The present invention is when practical application, can be to be unit with the gram, for example, can choose Radix Ginseng 210 grams, Radix Sophorae Flavescentis 350 grams, Radix Polygoni Multiflori 560 grams, Rhizoma Chuanxiong 420 grams and Eclipta prostrata 140 grams as prescription drugs, totally 1680 grams through method of the present invention, are made the 1000g clear paste, its density 1.10-1.35,55 ℃.
Because the plant essence that extracts is rich in the present invention from Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Eclipta prostrata, can moisten hair follicle, improve scalp condition, hairy root nourishing, can prevent alopecia, and help natural on-off cycles of hair growth.Occupation mode of the present invention can be that the clear paste that different formulations is prepared from directly is applied in alopecia place, promptly gets this product and evenly is applied in hair in right amount, uses the light finger forlement, and kept 5-15 minute, every day 1 time, reusable in case of necessity, this kind usage effect is the most significant.Certainly in order to simplify step, the present invention can mix use with shampoo fully, directly carries out hair-loss preventing and hair-restoring in the process of hair washing, and its effect also is pretty good.
Select for use hair-loss preventing and hair-restoring medicinal composition provided by the present invention when carrying out in vitro tests, choose different regions respectively, the experimenter of variety classes alopecia tests, and its result is as follows:
1, choose Radix Ginseng 120 grams, Radix Sophorae Flavescentis 280 grams, Radix Polygoni Multiflori 360 grams, Rhizoma Chuanxiong 200 grams, Eclipta prostrata 200 grams are made the clear paste that density is 1.10-1.35 by method provided by the present invention, moderate seborrheic alopecia person 30 people are carried out human trial, male 21 people wherein, women 9 people, age distribution is in 25-59 year, smear one to twice in alopecia place every day, 15 days each courses of treatment, use 3 courses of treatment continuously, each detailed inspection course of treatment has or not whole body and local untoward reaction, and itemized record to 3 end course of treatment, its result shows that 30 people all do not have part or systemic adverse reactions, well educate 26 people that send out and obviously alleviate seborrheic alopecia and have, can alleviate 3 people of seborrheic alopecia, complete 1 invalid people, its total effective rate accounts for 96.7%.
2, choose Radix Ginseng 56 grams, Radix Sophorae Flavescentis 448 grams, Radix Polygoni Multiflori 280 grams, Rhizoma Chuanxiong 224 grams, it is that the clear paste of 1.10-1.35 carries out human trial to moderate because of white collar 50 people of the big alopecia of pressure that Eclipta prostrata 168 gram is made density by method provided by the present invention, male 26 people wherein, women 24 people, age distribution is in 26-40 year, smear once in alopecia place every day, 10 days each courses of treatment, use 3 courses of treatment continuously, each detailed inspection course of treatment has or not whole body and local untoward reaction, and itemized record to 3 end course of treatment, its result shows, 50 people all do not have part or systemic adverse reactions, well educate 42 people that send out and obviously alleviate alopecia and have, and can alleviate 7 people of alopecia, complete 1 invalid people, its total effective rate accounts for 98.0%.
3, choose Radix Ginseng 252 grams, Radix Sophorae Flavescentis 378 grams, Radix Polygoni Multiflori 441 grams, Rhizoma Chuanxiong 378 grams, it is that the clear paste moderate of 1.10-1.35 is carried out human trial because of unskilled labor author 100 people of other factor alopecias that Eclipta prostrata 252 gram is made density by method provided by the present invention, male 49 people wherein, women 51 people, age distribution is in 22-55 year, smear once in alopecia place every day, 12 days each courses of treatment, use 3 courses of treatment continuously, each detailed inspection course of treatment has or not whole body and local untoward reaction, and itemized record to 3 end course of treatment, its result shows, 100 people all do not have part or systemic adverse reactions, and obviously alleviate 85 people of alopecia, can alleviate 12 people of alopecia, complete 3 invalid people, its total effective rate accounts for 97%.
Meanwhile, the present invention also provides a kind of hair-loss preventing and hair-restoring shampoo that contains hair-loss preventing and hair-restoring medicinal composition, and this hair-loss preventing and hair-restoring shampoo comprises that percentage by weight is that the hair-loss preventing and hair-restoring pharmaceutical composition of 5-15%, the cleaning agent of 10-30% and the solvent preparation of 55-80% come.
Better for result of use, hair-loss preventing and hair-restoring shampoo provided by the present invention comprises that also percentage by weight is the hair conditioner of 2-5%, the thickening agent of 0.1-0.6%, the fragrant agent of 0.1-0.5%, the pearling agent of 1-5% and the antiseptic of 0.01-0.1%.
This cleaning agent can be one or more combinations of polyoxyethylenated alcohol sodium sulfate, ammonium lauryl sulfate, coconut oil diethanol amide and dodecylbenzene sodium sulfonate.
Solvent is a deionized water; Hair conditioner is a Cortex cocois radicis oleoyl propyl-dimethyl betanin; Pearling agent is a Pearl Concentrate; Thickening agent is a cationic guar gum; Fragrant agent is an essence; Antiseptic is methylchloroisothiazandnone and Methylisothiazolinone, certainly fragrant agent, antiseptic, hair conditioner be not limited to that the present invention enumerates this is several, all be feasible as long as can play the substitute products of identical function.
The inventor can have multiple proportioning embodiment through long-term practice, and this embodiment all can reach the effect that is highly profitable:
The preparation method that contains the shampoo of hair-loss preventing and hair-restoring shampoo provided by the present invention may further comprise the steps:
1) thickening agent, solvent and hair-loss preventing and hair-restoring pharmaceutical composition are added the homogenizing pot, be heated to 76-85 ℃, stir, kept 10-30 minute;
2) cleaning agent and hair conditioner are joined in the stainless steel cask, be heated to dissolving, treat to add when the homogenizing pot temperature is reduced to 70-75 ℃, stir, mixing speed is 15-25r/min.
3) treat to add when the homogenizing pot temperature is reduced to 50-55 ℃ pearling agent;
4) treat that the homogenizing pot temperature reduces to 40-45 ℃ and add fragrant agent and antiseptic, stir evacuation 8-15 minute;
5) treat that the homogenizing pot temperature reduces to 35-40 ℃ of discharging, fill was left standstill in sealing 36-80 hour.
The shampoo that contains hair-loss preventing and hair-restoring for preparing according to the production method of shampoo provided by the present invention, be rich in the plant essence that from Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Eclipta prostrata, extracts, hair follicle be can moisten, scalp condition, hairy root nourishing improved, can prevent alopecia, and help natural on-off cycles of hair growth.In cosmetics inspection mechanism this hair-loss preventing and hair-restoring liquid is detected and can prove through authorized by state, various physics and chemistry, microbiological indicator all meet the cosmetics health code requirement, show that through tuerculoderma repeatedly rabbit repeatedly skin irritation reaction integral mean value is 0, belongs to the nonirritant product; Simultaneously, under 30 second washing conditions, product is a microstimulation to the acute eye of rabbit irritant reaction intensity, and various tests show that all hair-loss preventing and hair-restoring shampoo result of use provided by the present invention is very good.
To carry out human trial according to the hair-loss preventing and hair-restoring shampoo that various proportioning embodiments obtain, its result is as follows:
1, choose percentage by weight and be 5% hair-loss preventing and hair-restoring pharmaceutical composition, 30% cleaning agent and 65% solvent and be prepared into hair-loss preventing and hair-restoring liquid moderate seborrheic alopecia person 70 people are carried out human trial, male 58 people wherein, women 12 people, age distribution is in 25-59 year, after soaking hair with warm water every day; get this product and evenly be applied in hair in right amount, use the light finger forlement, and kept 5-15 minute; with clear water hair is cleaned then and get final product; reusable in case of necessity, every day 1 time, used continuously 2 months; detailed inspection every day has or not whole body and local untoward reaction; and itemized record to 2 month finish, its result shows that 70 people all do not have part or systemic adverse reactions; well educate 54 people that send out and obviously alleviate seborrheic alopecia and have; can alleviate 10 people of seborrheic alopecia, complete 6 invalid people, and its total effective rate accounts for 91.4%.
2, choose percentage by weight and be 12% hair-loss preventing and hair-restoring pharmaceutical composition, 26% cleaning agent, 2% hair conditioner, 0.1% thickening agent, 0.3% fragrant agent, 2% pearling agent, 0.01 antiseptic and 58.59% solvent and be prepared into hair-loss preventing and hair-restoring liquid moderate and carry out human trial because of white collar 150 people of the big alopecia of pressure, male 87 people wherein, women 63 people, age distribution is in 26-40 year, after soaking hair with warm water every day; get this product and evenly be applied in hair in right amount; use the light finger forlement; and kept 5-15 minute; with clear water hair is cleaned then and get final product; reusable in case of necessity, every day 1 time, used continuously 2 months; detailed inspection every day has or not whole body and local untoward reaction; and itemized record to 2 month finish, its result shows that 150 people all do not have part or systemic adverse reactions; well educate 124 people that send out and obviously alleviate alopecia and have; can alleviate 19 people of alopecia, complete 7 invalid people, and its total effective rate accounts for 95.3%.
3, choose percentage by weight and be 8% hair-loss preventing and hair-restoring pharmaceutical composition, 11% cleaning agent, 5% hair conditioner, 0.4% thickening agent, 0.3% fragrant agent, 2% pearling agent, 0.1 antiseptic and 73.2% solvent and be prepared into hair-loss preventing and hair-restoring liquid and carry out human trial because of unskilled labor author 100 people of other factor alopecias, male 49 people wherein, women 51 people, age distribution is in 22-55 year, after soaking hair with warm water every day; get this product and evenly be applied in hair in right amount; use the light finger forlement; and kept 5-15 minute; with clear water hair is cleaned then and get final product; reusable in case of necessity, every day 1 time, used continuously 2 months; detailed inspection every day has or not whole body and local untoward reaction; and itemized record to 2 month finish, its result shows that 100 people all do not have part or systemic adverse reactions; well educate 58 people that send out and obviously alleviate alopecia and have; can alleviate 35 people of alopecia, complete 7 invalid people, and its total effective rate accounts for 93.0%.
Claims (14)
1. hair-loss preventing and hair-restoring pharmaceutical composition is characterized in that: described hair-loss preventing and hair-restoring pharmaceutical composition is to be that 1～4 part Radix Ginseng, 5～9 parts Radix Sophorae Flavescentis, 5～9 parts Radix Polygoni Multiflori, 3～6 parts Rhizoma Chuanxiong and 2～6 parts Eclipta prostrata are prepared from by weight portion.
2. hair-loss preventing and hair-restoring pharmaceutical composition according to claim 1 is characterized in that: described hair-loss preventing and hair-restoring pharmaceutical composition is to be that 2～3 parts Radix Ginseng, 6～8 parts Radix Sophorae Flavescentis, 6～8 parts Radix Polygoni Multiflori, 4～5 parts Rhizoma Chuanxiong and 3～5 parts Eclipta prostrata are prepared from by weight portion.
3. method for preparing claim 1 or 2 described hair-loss preventing and hair-restoring pharmaceutical compositions is characterized in that: said method comprising the steps of:
1) getting Radix Ginseng, Radix Sophorae Flavescentis, Radix Polygoni Multiflori, Rhizoma Chuanxiong and Eclipta prostrata cleans standby;
2) Radix Ginseng, Radix Polygoni Multiflori and Rhizoma Chuanxiong are carried out alcohol extraction, obtain alcohol extraction clear paste and alcohol extraction medicinal residues, standby;
3) with step 2) resulting alcohol extraction medicinal residues and Radix Sophorae Flavescentis and Eclipta prostrata carry out water and carry, and obtaining water, to carry clear paste standby, and water is carried medicinal residues and is abandoned;
4) the resulting water of step 3) is carried clear paste and carries out precipitate with ethanol, obtain water behind the precipitate with ethanol carry clear paste and with step 2) resulting alcohol extraction clear paste mixes, and obtains the ethanol extract, medicinal residues are standby;
5) medicinal residues that step 4) is obtained carry out the extraction of precipitate with ethanol medicinal residues, obtain the water extract.
4. the preparation method of hair-loss preventing and hair-restoring pharmaceutical composition according to claim 3 is characterized in that: specific implementation described step 2) is:
Get Radix Ginseng, Radix Polygoni Multiflori, Rhizoma Chuanxiong and doubly measure 80% ethanol extraction 1～3 time, collect all filtrates, cross 200 mesh sieves with 7-10, at decompression recycling ethanol below 70～80 ℃, and filtrate is concentrated into the clear paste that density is 1.10-1.35, and obtain alcohol extraction clear paste and alcohol extraction medicinal residues, standby.
5. the preparation method of hair-loss preventing and hair-restoring pharmaceutical composition according to claim 4 is characterized in that: the specific implementation of described step 3) is:
With step 2) resulting alcohol extraction medicinal residues and Radix Sophorae Flavescentis, Eclipta prostrata carry out water and carry 1～3 time, collects all filtrates, crosses 100 mesh sieves, and it is standby that the water that is concentrated into density and is 1.10-1.35 is carried clear paste, and water is carried medicinal residues and is abandoned.
6. the preparation method of hair-loss preventing and hair-restoring pharmaceutical composition according to claim 5 is characterized in that: the specific implementation of described step 4) is:
The resulting water of step 3) is carried clear paste carry out precipitate with ethanol, utilize 70% ethanol precipitate with ethanol 18-36 hour, cross 200 mesh sieves, reclaim ethanol, the water that filtrate is concentrated into behind the precipitate with ethanol that density is 1.10-1.35 is carried clear paste, with step 2) resulting alcohol extraction clear paste mixes, obtain the ethanol extract, medicinal residues are standby.
7. the preparation method of hair-loss preventing and hair-restoring pharmaceutical composition according to claim 6 is characterized in that: the specific implementation of described step 5) is:
5) medicinal residues that step 4) is obtained carry out the extraction of precipitate with ethanol medicinal residues, cross 200 mesh sieves, get pure slag liquid, are concentrated into the clear paste that density is 1.10-1.35, obtain the water extract.
8. hair-loss preventing and hair-restoring shampoo that contains claim 1 or 2 described hair-loss preventing and hair-restoring pharmaceutical compositions is characterized in that: described hair-loss preventing and hair-restoring shampoo comprises that percentage by weight is that the hair-loss preventing and hair-restoring pharmaceutical composition of 5-15%, the cleaning agent of 10-30% and the solvent preparation of 55-80% come.
9. hair-loss preventing and hair-restoring shampoo according to claim 8 is characterized in that: described solvent is a deionized water.
10. hair-loss preventing and hair-restoring shampoo according to claim 8 is characterized in that: described cleaning agent is one or more combinations of polyoxyethylenated alcohol sodium sulfate, ammonium lauryl sulfate, coconut oil diethanol amide and dodecylbenzene sodium sulfonate.
11. according to Claim 8 or 9 or 10 described hair-loss preventing and hair-restoring shampoos, it is characterized in that: described hair-loss preventing and hair-restoring shampoo also adds the hair conditioner that percentage by weight is 2-5%, the thickening agent of 0.1-0.6%, the fragrant agent of 0.1-0.5%, the pearling agent of 1-5% and the antiseptic of 0.01-0.1%.
12. hair-loss preventing and hair-restoring shampoo according to claim 11 is characterized in that: described hair conditioner is a Cortex cocois radicis oleoyl propyl-dimethyl betanin; Described pearling agent is a Pearl Concentrate; Described thickening agent is a cationic guar gum; Described fragrant agent is an essence; Described antiseptic is methylchloroisothiazandnone and Methylisothiazolinone.
13. a preparation method that contains the described hair-loss preventing and hair-restoring shampoo of claim 12 is characterized in that: said method comprising the steps of:
1) thickening agent, solvent and hair-loss preventing and hair-restoring pharmaceutical composition are added the homogenizing pot, be heated to 76-85 ℃, stir, kept 10-30 minute;
2) cleaning agent and hair conditioner are joined in the stainless steel cask, be heated to dissolving, treat to add when the homogenizing pot temperature is reduced to 70-75 ℃, stir;
3) treat to add when the homogenizing pot temperature is reduced to 50-55 ℃ pearling agent;
4) treat that the homogenizing pot temperature reduces to 40-45 ℃ and add fragrant agent and antiseptic, stir evacuation 8-15 minute;
5) treat that the homogenizing pot temperature reduces to 35-40 ℃ of discharging, fill was left standstill in sealing 36-80 hour.
14. the preparation method of hair-loss preventing and hair-restoring shampoo according to claim 13 is characterized in that: mixing speed is 15-25r/min described step 2).
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| CN2010102425332A CN101890080B (en) | 2010-08-02 | 2010-08-02 | Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof |
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| CN2010102425332A CN101890080B (en) | 2010-08-02 | 2010-08-02 | Hair-loss preventing and hair-restoring medicinal composition and preparation method thereof, shampoo containing medicinal composition and preparation method thereof |
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| CN101890080B true CN101890080B (en) | 2011-10-19 |
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| CN105168061A (en) * | 2015-09-24 | 2015-12-23 | 苏州科豪生物制品有限公司 | Shampoo and preparation method thereof |
| CN106821910A (en) * | 2017-03-13 | 2017-06-13 | 广州有传生物科技有限公司 | Trichomadesis-preventing hair-growing composition and preparation method thereof |
| CN106821807A (en) * | 2017-03-13 | 2017-06-13 | 广州有传生物科技有限公司 | Hair-loss preventing and hair-restoring shampoo and preparation method thereof |
| CN107019789B (en) * | 2017-05-27 | 2020-09-11 | 云南白药集团股份有限公司 | Anti-hair loss and hair-growing traditional Chinese medicine composition, preparation method and application thereof |
| CN107789520A (en) * | 2017-10-30 | 2018-03-13 | 李翠香 | A kind of draft nutrition hair tonic turns black medicine in vain |
| CN108785165A (en) * | 2018-07-08 | 2018-11-13 | 深圳市沃曼生物科技有限公司 | A kind of herbaceous plant extract liquor and preparation method thereof that can promote natural on-off cycles of hair growth |
| CN113288853A (en) * | 2021-03-02 | 2021-08-24 | 本草生活(北京)医学研究有限公司 | Natural composition tincture for nourishing hair follicles, preventing alopecia, promoting hair growth, resisting inflammation and resisting bacteria and preparation method thereof |
| CN114939095A (en) * | 2022-06-22 | 2022-08-26 | 烟台新时代健康产业日化有限公司 | Oil-control and hair loss-prevention composition, preparation method thereof, hair-care spray and shampoo |
| CN116617356B (en) * | 2023-07-19 | 2023-11-21 | 可氏利夫(深圳)生物科技有限公司 | Alopecia preventing composition, and preparation method and application thereof |
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| CN100441168C (en) * | 2005-09-30 | 2008-12-10 | 张七一 | Chinese medicine external-use liniment for treating lipsotrichia and regenerating hair |
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