CN101889915B

CN101889915B - Artificial vertebral lamina

Info

Publication number: CN101889915B
Application number: CN2010102384972A
Authority: CN
Inventors: 史建刚; 李陵江; 贾连顺; 袁文; 刘青; 孙庆文
Original assignee: Second Military Medical University SMMU
Current assignee: Second Military Medical University SMMU
Priority date: 2010-07-27
Filing date: 2010-07-27
Publication date: 2012-09-12
Anticipated expiration: 2030-07-27
Also published as: CN101889915A

Abstract

The invention relates to an artificial neural plate, belonging to the technical field of medical equipment. The artificial neural plate is a matrix with a approximately lambdoid cross section and with an axial length. The matrix comprises three indent curved surfaces, the surface of one indent curved surface is smooth, and the surfaces of the other two indent curved surfaces are provided with a plurality of small cylinders. The invention has the following beneficial effects that the artificial neural plate has simple structure and convenient use, the matrix provided with small cylinders can provide good support for new bone growth and deposition and is favor of growth and deposition of new bones; and the material of the artificial neural plate is a polymer capable of being degraded and absorbed by human body, has strong capability for inducing target cells to be differentiated into bone cells and is favor of better and faster development of new bones.

Description

Artificial neural plate

Technical field

The present invention relates to a kind of apparatus that is used for fixing vertebra of technical field of medical instruments, specifically is a kind of artificial neural plate.

Background technology

Laminectomy is a spinal surgery modus operandi relatively more commonly used, is often referred to by spinal column way of escape cut-out or whole vertebral plate, exposes canalis spinalis and also clears up intraspinal pathological changes.But because of operation has destroyed the spinal column posterior column structure, part patient forms scar tissue at the vertebral plate defective region to vertebral plate, with dura mater and nerve root adhesion after excision; Involve, pressuring nerve; Make the postoperative symptomatic recurrence, often cause lumbar vertebra postoperative failure syndrome (FBSS), have a strong impact on the long-term effect of spinal operation; How preventing the generation of this complication, is the problem that field of spinal surgery needs to be resolved hurrily.

(artificial lamina is in human vertebra vertebral arch excision or former thereby when causing disappearance like pathological changes etc. because of other AL) to artificial neural plate, can be used as a kind of artificial implant that uses when repairing is implanted in this excision or disappearance position; The Secondary cases cicatricial adhesion that artificial neural plate is caused the vertebrae plate resection postoperative; The unstable spine that causes oppressing dural sac and nerve root and cause has preventive effect; Artificial neural plate can be kept apart dura mater and musculus sacrospinalis matsurface effectively; Can prevent that opisthogenesis property fibrous tissue from growing in canalis spinalis, also can prevent the compressing of scar tissue simultaneously dural sac and spinal cord.Ideal artificial neural plate should meet the physiology and appearance 26S Proteasome Structure and Function anatomical features of human body vertebral plate; Also should possess to functional bone directed differentiation alive and for the benefit of area of new bone cell deposition and the ability that provides support of growth, this artificial neural plate can be repaired the damaged of vertebral plate fully, participates in surrounding canalis spinalis; Protected dural sac to avoid compressing; Avoid adhesion, stablized spinal column, prevent the generation of complication such as postoperative restenosis.

Artificial neural plate configuration of the prior art is simpler; Can not support for the area of new bone cell provides good deposition; Be unfavorable for the growth of area of new bone, (Granted publication day: 2003.6.25) disclosed a kind of artificial neural plate (referring to Fig. 1), this vertebral plate is that a cross section is arc curve form and the matrix 1 that has axial length simultaneously like Chinese invention patent ZL 02275837.2; At least the lateral cross section of indent in its arc curve form cross section is a circular arc; The matrix of this artificial neural plate lacks support on each side, be unfavorable for the deposition of area of new bone cell, and operation back hematocele is in time discharged; Simultaneously the artificial neural plate of prior art induces target cell to be divided into bone to be that the ability of cell is relatively poor, to be unfavorable for inducing the growth of new bone.

Summary of the invention

It is relatively poor to the objective of the invention is to overcome artificial neural plate bone conduction of the prior art and bone inducibility, is unfavorable for new osteogenetic technical problem, and a kind of artificial neural plate that is beneficial to new bone growth more is provided.

The artificial neural plate that the present invention relates to is that cross section roughly is the matrix that herringbone also has axial length simultaneously; Said matrix comprises three inner sunken faces; The surface of one of them inner sunken face is slick, and the surface of all the other two inner sunken faces is provided with a plurality of little cylinders.

Preferably, said cylinder is a cylinder.

Preferably, said cylindrical height is 1.8～2mm, and the cross section radius is 0.05～0.1mm.

Preferably, the top of said cylinder is set to spheroid.

Preferably, the radius of said spheroid is 0.2～0.4mm.

Preferably, be provided with aperture between the said cylinder.

Preferably, the radius of said aperture is 0.05～0.08mm.

Preferably, the material of said artificial neural plate is polycaprolactone-lactic acid/alcohol copolymer or porous calcium phosphate.

The present invention has following beneficial effect: artificial neural plate of the present invention is simple in structure, and is easy to use, after on the matrix paxilla being set, can good supporting be provided for new bone growth and deposition, is beneficial to the growth and the deposition of new bone more; The material of artificial neural plate of the present invention is to be had the stronger target cell of inducing and to be divided into the ability that bone is a cell by the polymer of human body degraded and absorbed simultaneously, is beneficial to new bone and grows better faster.

Description of drawings

Fig. 1 is an artificial neural plate structural representation of the prior art;

Fig. 2 is the artificial neural plate structural representation of embodiment 1;

Fig. 3 is the cylinder body shape sketch map of the artificial neural plate of embodiment 2;

Fig. 4 is the artificial neural plate structural representation of embodiment 3;

Fig. 5 is the user mode sketch map of the artificial vertebral plate of the present invention.

The specific embodiment

Below in conjunction with specific embodiment, the present invention is described further.Should be understood that following examples only are used to the present invention is described but not are used to limit scope of the present invention.

Embodiment 1

The structural representation of the artificial neural plate of present embodiment is seen Fig. 2, and is as shown in the figure, and this artificial neural plate is that cross section roughly is the matrix 1 that herringbone also has axial length simultaneously; Said matrix 1 comprises three

inner sunken faces

2,3 and 4; The surface of one of them inner sunken face 4 is slick, and the surface of this inner sunken face 4 is covered with adherence preventing material, and all the other two

inner sunken faces

2 and 3 surface are provided with a plurality of little cylinders 5; The height of cylinder 5 is 1.8～2mm; Be preferably 1.83mm, the cross section radius is 0.05～0.1mm, is preferably 0.1mm; Cylinder 5 is rich in BMP (bone morphogenetic protein, bone induce and generate albumen) granule, and new osteogenesis is had inducing action; The material of the artificial neural plate of present embodiment can be polycaprolactone-lactic acid/alcohol copolymer (one Chinese patent application 200710300691.7) or porous calcium phosphate (old conformality; Model is kind impartial. porous calcium phosphate artificial neural plate experimental study on application [J]. and Chinese spinal column vertebra magazine; 1998; 8 (6): 326-328), these materials all can be by the human body degraded and absorbed.

Fig. 5 is the user mode sketch map of the artificial neural plate of present embodiment; As shown in the figure; Inner sunken face 4 corresponding medullary canals 7 with matrix 1 are fastened on the vertebra, form closed space with protection medullary canal 7 with vertebra; Be arranged at the deposition that cylinder 5 on inner

sunken face

2 and 3 can be the area of new bone cell respectively good supporting is provided, make area of new bone to grow fast according to both shaped of artificial neural plate; Simultaneously owing to the material non-toxic of present embodiment artificial neural plate, have good biocompatibility, and this material to induce target cell to be divided into bone be that the ability of cell is stronger, so be beneficial to the growth of new bone more.

Embodiment 2

The artificial neural plate of present embodiment is the further improvement of on the basis of embodiment 1 artificial neural plate, being done, and the spheroid (see figure 3) is arranged at the top that is about to cylinder 5, and the radius of said spheroid is 0.2～0.4mm, is preferably 0.2mm.Adhesion and the contact area that spheroid can enlarge artificial neural plate and area of new bone target cell is arranged at the top of cylinder 5, is beneficial to the growth and the deposition of new bone more, makes the quick growth shaping of area of new bone.

Embodiment 3

The artificial neural plate of present embodiment is the further improvement of on the basis of embodiment 1 artificial neural plate, being done; Between cylinder 5, also be provided with aperture 6 (as shown in Figure 4); The radius of said aperture 6 is 0.05～0.08mm, is preferably 0.05mm, and this aperture 6 is depressed on the inner sunken face of matrix 1.Be arranged so that area of new bone cell and other functional cells of aperture 6 are deposited on this, are convenient to form an intensive relatively cell colony, are beneficial to and produce biological action between the cell, promote the differentiation and the growth of area of new bone cell.

Through experimental verification, artificial neural plate of the present invention is in use by degraded gradually, finally when new bone formation, degrades fully and is absorbed by the body, and has very high safety.

Claims

1. artificial neural plate; It is characterized in that; This artificial neural plate is that cross section roughly is the matrix that herringbone also has axial length simultaneously, and said matrix comprises three inner sunken faces, and the surface of one of them inner sunken face is slick; The surface of all the other two inner sunken faces is provided with a plurality of little cylinders, wherein:

Said cylindrical height is 1.8～2mm, and cylindrical cross section radius is 0.05～0.1mm;

Said cylindrical top is set to spheroid, and the radius of said spheroid is 0.2～0.4mm;

Also be provided with aperture between the said cylinder, the radius of said aperture is 0.05～0.08mm.

2. artificial neural plate according to claim 1 is characterized in that, the material of said artificial neural plate is polycaprolactone-lactic acid/alcohol copolymer or porous calcium phosphate.