CN101879225A - Genuine medicinal material paeoniflorin producing and processing method capable of reducing paeoniflorin loss - Google Patents
Genuine medicinal material paeoniflorin producing and processing method capable of reducing paeoniflorin loss Download PDFInfo
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- CN101879225A CN101879225A CN 201010217427 CN201010217427A CN101879225A CN 101879225 A CN101879225 A CN 101879225A CN 201010217427 CN201010217427 CN 201010217427 CN 201010217427 A CN201010217427 A CN 201010217427A CN 101879225 A CN101879225 A CN 101879225A
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- China
- Prior art keywords
- radix paeoniae
- paeoniae alba
- paeoniflorin
- root
- drying oven
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- YKRGDOXKVOZESV-WRJNSLSBSA-N Paeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-WRJNSLSBSA-N 0.000 title claims abstract description 41
- 238000003672 processing method Methods 0.000 title claims abstract description 13
- 239000000463 material Substances 0.000 title claims abstract description 11
- YKRGDOXKVOZESV-UHFFFAOYSA-N paeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(CO)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 YKRGDOXKVOZESV-UHFFFAOYSA-N 0.000 title abstract description 16
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 59
- 238000001035 drying Methods 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000005406 washing Methods 0.000 claims abstract description 9
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- 206010062575 Muscle contracture Diseases 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
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- 229910052717 sulfur Inorganic materials 0.000 description 2
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 1
- LATYEZNGPQKAIK-UHFFFAOYSA-N 6'-O-benzoylpaeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(COC(=O)C=6C=CC=CC=6)O5)O)CC3(O)OC1C24COC(=O)C1=CC=CC=C1 LATYEZNGPQKAIK-UHFFFAOYSA-N 0.000 description 1
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- LATYEZNGPQKAIK-HRCYFWENSA-N Benzoylpaeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@]1(C[C@@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C=2C=CC=CC=2)O1)O)C)OC(=O)C1=CC=CC=C1 LATYEZNGPQKAIK-HRCYFWENSA-N 0.000 description 1
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- VIWQCBZFJFSCLC-UHFFFAOYSA-N alpha-benzoyloxypaeoniflorin Natural products O1C(C)(C2(CC34)OC5C(C(O)C(O)C(COC(=O)C=6C=CC=CC=6)O5)O)CC3(O)OC1C24COC(=O)C1=CC=C(O)C=C1 VIWQCBZFJFSCLC-UHFFFAOYSA-N 0.000 description 1
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- YTJSFYQNRXLOIC-UHFFFAOYSA-N octadecylsilane Chemical compound CCCCCCCCCCCCCCCCCC[SiH3] YTJSFYQNRXLOIC-UHFFFAOYSA-N 0.000 description 1
- 239000009835 oxypaeoniflora Substances 0.000 description 1
- FCHVXNVDFYXLIL-QYDSDWLYSA-N oxypaeoniflorin Chemical compound C([C@]12[C@H]3O[C@]4(O)C[C@](O3)([C@@]1(C[C@H]42)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)C)OC(=O)C1=CC=C(O)C=C1 FCHVXNVDFYXLIL-QYDSDWLYSA-N 0.000 description 1
- RLXWQODPAWIVOI-UHFFFAOYSA-N oxypaeoniflorin Natural products OCC1OC(OC23CC4C5(O)CC2OC(O5)C34COC(=O)c6ccc(O)cc6)C(O)C(O)C1O RLXWQODPAWIVOI-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a genuine medicinal material paeoniflorin producing and processing method capable of reducing paeoniflorin loss, which comprises the following steps of: cutting the roots of radix paeoniae albas, cutting the fleshy roots, separating the large ones from the small ones, shaking off the soil, and cleaning by water via a herbal medicine washing machine; placing the radix paeoniae albas the soil of which is cleaned off into a microwave drying oven, rapidly heating to soften the radix paeoniae alba roots by utilizing the microwave heating and drying principle, until half-softening, taking out, and peeling off; placing the radix paeoniae alba roots which are peeled off into the microwave drying oven to dry and soften, until the water content of the medicinal material is dried to be 15-25%, taking out and transferring to a herbal medicine slicing machine to slice; and drying the slices in the shade until the water content is less than 13%, obtaining the radix paeoniae alba slices for decoction, and packaging. The invention has the advantages of convenient operation, short time cost, high efficiency, water resource conservation, reduced waste water discharge, better preserved paeoniflorin, lowered paeoniflorin loss, and not less than 2.8% of the content of the paeoniflorin.
Description
[technical field]
The present invention relates to the white Peony Root processing technique field, specifically, is a kind of genuine medicinal materials Bo Radix Paeoniae Alba production and processing method that reduces the peoniflorin ingredients from lossing.
[background technology]
Chinese patent publication number CN1416888 relates to Radix Paeoniae Alba Radix Glycyrrhizae extract and preparation method thereof, the present invention relates to Radix Paeoniae Alba Radix Glycyrrhizae extract and preparation method thereof, the Radix Paeoniae Alba of the present invention: the proportioning of Radix Glycyrrhizae is 1: 1～3: 1 by weight, concrete preparation method sees description for details, advantage of the present invention is that extract contains Radix Paeoniae Alba total glucosides, Radix Glycyrrhizae total flavones, three effective part groups of Radix Glycyrrhizae triterpenic acid, total content is greater than 50%, good effect, any 1～3 combination in three positions, independent or compatibility uses the relieving spasm to stop pain effect that all has in various degree, and three kinds of extract isolated compatibilities use all has significant analgesia role, and the sweet extract of Chinese herbaceous peony is made dry powder can make oral formulations or injection, product of the present invention has sour and sweet drugs can transforme into YIN, the function of relieving spasm to stop pain, cure mainly deficiency of YIN-blood, hematogenous blockage, disease is seen contracture of the limbs, muscle arteries and veins contracture, epigastric pain etc.Be used for the relieving spasm to stop pain and the hepatoprotective that nourishes blood of the anxious pain of acute and chronic contraction of nerve, muscle and internal organs, the pain relieving of detoxifying, fall enzyme and take off Huang, treatment acute and chronic viral hepatitis etc.
Chinese patent publication number CN1194834 relates to a kind of new method of extracting white peony root's total glycoside, the invention discloses a kind of new method of extracting white peony root's total glycoside, this method is raw material with the Radix Paeoniae Alba, extract with alcohol-water solution, use the alcohol ester solution extraction, through concentrate drying, obtain the Radix Paeoniae Alba total glucosides powder, the yield of this method is 5～7%.
Chinese patent publication number CN1040030 relates to the extraction process of effective component of paeonia lactiflora, and this technology is a kind of extracting method that improves effective component of paeonia lactiflora, it is characterized in that with sodium bicarbonate (NaHCO
3) solution replaces the ether in original technology, dilute neutralization, and then extract with ethyl acetate.This technology of having improved has equipment, operation is simple, and with short production cycle, raw material sources are wide, solvent safety coefficient height.With the product of this explained hereafter,, confirm the nonhazardous effect, the characteristics that effect is good through pharmacological testing and clinical use.
Chinese patent publication number CN101297874 relates to a kind of extraction process of high-content effective composition from white peony root, the invention provides a kind of extraction process of high-content effective composition from white peony root, comprise slightly carry, step such as dissolving, purification, described slightly carrying adopts alcohol-water solution to extract, use the alcohol ester solution extraction, through concentrate drying, get Radix Paeoniae Alba crude extract, described purification adopts macroporous adsorbent resin to carry out adsorbing separation, and technology of the present invention has improved content of paeoniflorin greatly, reaches 60～90%, this technological operation is easy, cost is lower, and resin can use repeatedly, is fit to commercial production.
Chinese patent publication number CN101297878 relates to a kind of preparation technology of high-content effective composition from white peony root, invention provides a kind of preparation technology of high-content effective composition from white peony root, comprise alcohol reflux, ethyl acetate extraction, concentrate drying, hydrophilic solvent dissolving and adopt macroporous adsorbent resin to carry out purification, improved content of paeoniflorin greatly, reach 60～90%, this technological operation is easy, and cost is lower, resin can use repeatedly, is fit to commercial production.
The Bozhou abounds with Chinese crude drug, and the title of " medicine all " is just arranged from ancient times.From Eastern Han Dynasty last years of a dynasty or reign, highly skilled doctor Huatuo opens up first " medicine garden " beginning, and the wind of planting, manage medical material is lasting, the history in existing more than 2100 year.The genuine traditional Chinese medicine material has more than 20 kinds such as " Bo Chinese herbaceous peony, BOJU, Bo pollen, Bo Cortex Mori ", and is the most famous with Radix Paeoniae especially, is called as " Bo Chinese herbaceous peony ".The annual production of Bo Chinese herbaceous peony accounts for about 75% of national output, and Bozhou City Chinese crude drug cultivated area has developed into more than 100 ten thousand mu at present.1994, the Chinese crude drug trade center of national maximum was built up in the Bozhou.
Radix Paeoniae also is the rare medicinal herbs flowers, after the processing of Radix Paeoniae root, is called the medicinal Radix Paeoniae Alba, be large medical material kind, for the ranunculaceae plant Radix Paeoniae is removed the root of crust, bitter in the mouth, acid, be slightly cold, go into Liver Channel, the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain, the suppressing the hyperactive liver sun, be used for menoxenia, abdominal pain during menstruation, metrorrhagia, and disease such as spontaneous perspiration, night sweat, annual requirement is greatly about 10,000 tons.
Radix Paeoniae Alba perennial herb, high 50～80cm.The leaf alternate has long handle; The lower portion of the stem leaf is to go out winglike compound leaf 2 times three, and the branch end is single leaf; Narrow avette, lanceolar of lobule or ellipse, the little tooth of edge tool hyaloidin.Hua Dingsheng and axil are given birth to; Sepal 4, little aubergine; Petal 6～9, white, pink or aubergine; The stamen majority; Carpel 4～5 does not have the white hair of hair or close quilt, and follicle is avette, and tip curves hook-shaped outward.In May at florescence, the Radix Paeoniae root is received and dug season is that late September is to early October.
Radix Paeoniae Alba chemical constitution study: paeoniflorin 3.3%, also contain peony lactone glycoside 0.06～0.07%, oxypaeoniflorin, benzoylpaeoniflorin 0.04%, the lucky ketone of Radix Paeoniae, hydroxypaeoniflorin 0.12～0.21%.Content of paeoniflorin directly influences the curative effect of the Radix Paeoniae Alba, and " Chinese pharmacopoeia regulation peoniflorin is a Bo Radix Paeoniae Alba important quality index.
Yet traditional Bo Radix Paeoniae Alba genuine medicinal materials processing method peoniflorin yield is low, and peoniflorin runs off serious.Its processing method is: Radix Paeoniae Alba root is cleaned soaked into, steam or boiling, pull rossing, section then out, smoked with sulfur, dry in the sun is to doing again.The a large amount of waters of whole process, Jia Gong medical material like this, the Radix Paeoniae Alba often all is blue, and its reason is exactly that peoniflorin is water-soluble, and effective ingredient runs off in a large number.For the color and luster that keeps the Radix Paeoniae Alba and dry rapidly, traditional method is smoked with sulfur, thereby causes heavy metal, pesticide residues, and might cause effective ingredient and SO such as Radix Paeoniae Alba glycosides
2Chemical reaction takes place.According to " Chinese pharmacopoeia is measured, and to the pharmaceutical decocting piece dry product, the turnover rate of peoniflorin can only obtain 1.0～1.8% peoniflorin roughly 60～70% to this method at last from medical material life product.
[summary of the invention]
The objective of the invention is to overcome the deficiencies in the prior art, a kind of genuine medicinal materials Bo Radix Paeoniae Alba production and processing method that reduces the peoniflorin ingredients from lossing is provided.
The objective of the invention is to be achieved through the following technical solutions:
A kind of genuine medicinal materials Bo Radix Paeoniae Alba production and processing method that reduces the peoniflorin ingredients from lossing, its concrete steps are:
(1) root with the Radix Paeoniae Alba digs, and downcuts fleshy tap root, and big or small stepping shrugs off silt, washes through medicine-washing machine;
(2) Radix Paeoniae Alba of removing silt after will washing is dropped into microwave drying oven, utilizes the micro-wave drying principle with the rapid thermoplastic of Radix Paeoniae Alba root, treats to a softening half, and taking-up scrapes off crust;
(3) Radix Paeoniae Alba root that will scrape peeling is again sent into microwave drying oven and is carried out drying and softening, is dried to the medical material water content at 15～25% o'clock, takes out to deliver to conveyer belt and cut into slices with medicine cutter;
(4) will cut into slices dry in the shade in the cool to water content below 13%, obtain Radix Paeoniae Alba decoction pieces, the packing; The technological parameter that technical scheme of the present invention is concrete is: get 3 years Radix Paeoniae Alba, root is dug, downcut fleshy tap root, by the diameter stepping, shrug off silt, get 10kg Radix Paeoniae Alba root and add 50kg water and clean with medicine-washing machine; Again the Radix Paeoniae Alba of flush away silt is dropped into microwave drying oven, dry heat 8～10 minutes; Take out, remove the peel with beaming machine; Again medical material is sent into microwave drying oven, dry 8～12 minutes, to the medical material water content 15～25%; Take out, (1～2mm) specification is evenly sent into medicine cutter with the Radix Paeoniae Alba after the peeling by transport tape, section to slice thickness to adjust medicine cutter; In time dry the packing of sieving, promptly obtain Radix Paeoniae Alba decoction pieces finished product.
Compared with prior art, good effect of the present invention is:
(1) Radix Paeoniae Alba decoction pieces processing method of the present invention is a kind of easy and simple to handle, method efficiently, is fit to that industry is big produces, and helps the foundation of production line, saves manpower, the efficient height;
(2) microwave drying oven selected for use of the present invention is to integrate the comprehensive equipment that dry heat is softened, and has characteristics such as few efficient height of time spent, has saved time cost;
(3) method of the present invention reduces the extensive application of water, so reduce the discharging of waste water, is beneficial to environmental conservation;
(4) Radix Paeoniae Alba processing method of the present invention can keep peoniflorin preferably, reduces peoniflorin and runs off, and content of paeoniflorin is not less than 2.8%, is higher than " Chinese pharmacopoeia Radix Paeoniae Alba content's index far away.
[specific embodiment]
The present invention below is provided a kind of specific embodiment that reduces the genuine medicinal materials Bo Radix Paeoniae Alba production and processing method of peoniflorin ingredients from lossing.
Radix Paeoniae Alba paeoniflorin content assay method (" Chinese pharmacopoeia): chromatographic condition and system suitability test: with octadecylsilane chemically bonded silica is filler; With second eyeball-0.1% phosphoric acid solution (14: 86) is mobile phase; The detection wavelength is 230nm.Number of theoretical plate calculates by the peoniflorin peak should be not less than 2000.
The preparation of reference substance solution: it is an amount of to get the peoniflorin reference substance, accurate claims surely, adds methanol system and contains the solution of 60ug to every 1ml, promptly.
The preparation of sample solution: get the about 0.1g of this product Chinese medicine powder, accurate claim surely, put in the 50ml measuring bottle, add Diluted Alcohol 35ml, supersound process (power 240W, frequency 45kHz) 30 minutes is put coldly, adds Diluted Alcohol to scale, shakes up, and filters, and gets subsequent filtrate, promptly.
Algoscopy: accurate respectively reference substance solution and each 10 μ l of sample solution of drawing, inject chromatograph of liquid, measure, promptly.
This product is pressed dry product and is calculated, and contains peoniflorin (C23H28O11) and must not be less than 1.6%.
Technical scheme of the present invention is: (1) digs the root of the Radix Paeoniae Alba, downcuts fleshy tap root, and big or small stepping shrugs off silt, washes through medicine-washing machine; (2) Radix Paeoniae Alba of removing silt after will washing is dropped into microwave drying oven, utilizes the micro-wave drying principle with the rapid thermoplastic of Radix Paeoniae Alba root, treats to a softening half, and taking-up scrapes off crust; (3) Radix Paeoniae Alba root that will scrape peeling is again sent into microwave drying oven and is carried out drying and softening, is dried to the medical material water content at 15～25% o'clock, takes out to deliver to conveyer belt and cut into slices with medicine cutter; (4) will cut into slices dry in the shade in the cool to water content below 13%, promptly get Radix Paeoniae Alba decoction pieces, the packing.
Embodiment 1
The influence of traditional method decocting in water time to Radix Paeoniae Alba glycosides is discussed
The method that adopts this experiment to provide steams different time and carries out paeoniflorin content mensuration.Take by weighing the same place of production, 3 years Radix Paeoniae Alba roots in same plot, remove removing LU and fleshy tap root, shrugging off silt cleans, (5 parts of diameter 1～2cm) 10kg Radix Paeoniae Alba roots steam 10,15,20,25,30 minutes respectively in airtight steaming and decocting symbol, taking out peels to dry makes medicated powder respectively to take by weighing median size, again 5 parts of medicated powder are made 3 parts of equivalent sample 0.1g respectively and average result such as table 1 by the described method mensuration of Chinese Pharmacopoeia peoniflorin.
Table 1
| The decocting in water time | Outward appearance | Peoniflorin (%) |
| ??10min | The section clean mark, hard-core, off-white color are arranged | ??2.52 |
| ??15min | Section clean mark, off-white color | ??2.23 |
| ??20min | Section clean mark, off-white color, part gelatinizing | ??1.80 |
| ??25min | Cambium layer is obvious, keratinization is obvious | ??1.65 |
| The decocting in water time | Outward appearance | Peoniflorin (%) |
| ??30min | Gelatinizing is obvious, and epidermis is ripe | ??0.93 |
The result shows: long more with digestion time, peoniflorin runs off serious more, and the water steaming and decocting causes peoniflorin to dissolve in water in a large number and runs off.
The influence of the inventive method microwave heating time to Radix Paeoniae Alba glycosides is discussed
The experimental technique that adopts this experiment to provide, to the same place of production, 3 years Radix Paeoniae Alba roots in same plot remove removing LU and fleshy tap root, shrug off silt and clean, take by weighing median size (5 parts of diameter 1～2cm) 10kg Radix Paeoniae Alba roots, microwave heating is 10,15,20,25,30 minutes respectively, takes out, and decortication is dried and made powder, again 5 parts of medicated powder are made 3 parts of equivalent sample 0.1g respectively and average result such as table 2 by the described method mensuration of Chinese Pharmacopoeia peoniflorin.
Table 2
| Microwave heating time | Peoniflorin (%) |
| ??10min | ??3.31 |
| ??15min | ??3.29 |
| ??20min | ??3.28 |
| ??25min | ??3.28 |
| ??30min | ??3.15 |
The result shows: with micro-wave drying Radix Paeoniae Alba root, its paeoniflorin content is little, more stable with changing heat time heating time, and the content height.
Conclusion: the inventive method is a kind of efficient than traditional Radix Paeoniae Alba processing method composition content of paeoniflorin of more remaining valid, the suitable big industrial processing method of saving cost.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, without departing from the inventive concept of the premise; can also make some improvements and modifications, these improvements and modifications also should be considered within the scope of protection of the present invention.
Claims (2)
1. genuine medicinal materials Bo Radix Paeoniae Alba production and processing method that reduces the peoniflorin ingredients from lossing is characterized in that concrete steps are:
(1) root with the Radix Paeoniae Alba digs, and downcuts fleshy tap root, and big or small stepping shrugs off silt, washes through medicine-washing machine;
(2) Radix Paeoniae Alba of removing silt after will washing is dropped into microwave drying oven, utilizes the micro-wave drying principle with the rapid thermoplastic of Radix Paeoniae Alba root, treats to a softening half, and taking-up scrapes off crust;
(3) Radix Paeoniae Alba root that will scrape peeling is again sent into microwave drying oven and is carried out drying and softening, is dried to the medical material water content at 15～25% o'clock, takes out to deliver to conveyer belt and cut into slices with medicine cutter;
(4) will cut into slices dry in the shade in the cool to water content below 13%, obtain Radix Paeoniae Alba decoction pieces, the packing.
2. a kind of genuine medicinal materials Bo Radix Paeoniae Alba production and processing method that reduces the peoniflorin ingredients from lossing as claimed in claim 1 is characterized in that, gets 3 years Radix Paeoniae Alba, root is dug, downcut fleshy tap root, by the diameter stepping, shrug off silt, get 10kg Radix Paeoniae Alba root and add 50kg water and clean with medicine-washing machine; Again the Radix Paeoniae Alba of flush away silt is dropped into microwave drying oven, dry heat 8～10 minutes; Take out, remove the peel with beaming machine; Again medical material is sent into microwave drying oven, dry 8～12 minutes, to the medical material water content 15～25%; Take out, adjust medicine cutter, the Radix Paeoniae Alba after the peeling is evenly sent into medicine cutter by transport tape, section to the slice thickness specification; In time dry the packing of sieving, obtain Radix Paeoniae Alba decoction pieces finished product.
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| CN102144459A (en) * | 2010-11-25 | 2011-08-10 | 高旌 | High-quality and high-yield planting method of paeonia lactiflora pall |
| CN104083459A (en) * | 2014-07-30 | 2014-10-08 | 李时珍医药集团有限公司 | Novel processing method of paeonia sterniana medicinal slices |
| CN104534820A (en) * | 2014-11-28 | 2015-04-22 | 浙江省中医药研究院 | Method for processing traditional Chinese medicinal material white paeony roots through microwave vacuum drying |
| CN104940312A (en) * | 2014-03-31 | 2015-09-30 | 江苏省中医药研究院 | Method for quickly processing white peony roots |
| CN106378068A (en) * | 2016-09-05 | 2017-02-08 | 东莞市华青微波设备制造有限公司 | Method and equipment for fast softening traditional Chinese medicine decoction tablet |
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| CN102144459A (en) * | 2010-11-25 | 2011-08-10 | 高旌 | High-quality and high-yield planting method of paeonia lactiflora pall |
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| CN104083459A (en) * | 2014-07-30 | 2014-10-08 | 李时珍医药集团有限公司 | Novel processing method of paeonia sterniana medicinal slices |
| CN104534820A (en) * | 2014-11-28 | 2015-04-22 | 浙江省中医药研究院 | Method for processing traditional Chinese medicinal material white paeony roots through microwave vacuum drying |
| CN106378068A (en) * | 2016-09-05 | 2017-02-08 | 东莞市华青微波设备制造有限公司 | Method and equipment for fast softening traditional Chinese medicine decoction tablet |
| CN109541099A (en) * | 2018-11-27 | 2019-03-29 | 山东省食品药品检验研究院 | A kind of discrimination method of Radix Paeoniae Alba rhizome or its extract |
| CN110561535A (en) * | 2019-08-30 | 2019-12-13 | 禹州市厚生堂中药有限公司 | moistening-free medicine cutting machine and method |
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