CN101874914B - Positioning system for photodynamic therapy and fluorescence diagnosis - Google Patents
Positioning system for photodynamic therapy and fluorescence diagnosis Download PDFInfo
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Abstract
The invention discloses a positioning system for photodynamic therapy and fluorescence diagnosis, which comprises a photodynamic therapy device, a multi-purpose LED medical light source system, an image acquisition device, an analysis processing system and a core control module group; the core control module group controls the photodynamic therapy device to output a therapy light source and controls the multi-purpose LED medical light source system to output an excitation light source, illumination light source or LED therapy light source; the therapy light source can enter the patient body through the biopsy port of an endoscope by using an optical fiber; and the output of the multi-purpose LED medical light source can enter the patient body through a light guiding channel of the endoscope and performs fluorescence diagnosis positioning, illumination or photodynamic therapy. The positioning system for photodynamic therapy and fluorescence diagnosis of the invention provides real-time image analysis, acquisition and observation for the endoscope or body surface throughout the process and performs positioning, analysis and judgment before and after tumor treatment by using the fluorescence diagnosis positioning, thereby ensuring good clinical effects of the photodynamic therapy and fluorescence diagnosis positioning in tumor treatment.
Description
Technical field
The present invention relates to medical instruments field, particularly a kind of optical dynamic therapy and fluorescence diagnosis navigation system.
Background technology
PDT (PDT) is a kind of under aerobic conditions, through the new method of photosensitizer treatment tumor in the specific wavelength optical excitation target cell.This method is to utilize tumor tissues can optionally absorb photosensitizer; Utilize the rayed diseased region of specific wavelength then; Make the photosensitizer in the tumor tissues that violent photochemical reaction take place; Mitochondrial molecule in the tumor cell is oxidized to singlet oxygen, and singlet oxygen causes and intensifies reaction, thereby optionally eliminates cancerous cell.PDT can be widely used in being inappropriate for carry out chemicotherapy, the cancer patient that performs an operation or be not suitable for performing an operation is unwilling.
There is the defective that relies on doctor's clinical experience and artificial error in judgement in traditional optical dynamic therapy.So in optical dynamic therapy, introduced light power fluorescence diagnosis location; Light power fluorescence diagnosis location is to utilize the affinity of tumor tissues to photosensitizer, and photosensitizer selectivity in tumor tissues is built up, and between pathological tissues and normal structure, forms significant concentration difference after a period of time; Under the excitation light irradiation of specific wavelength; pathological tissues is launched the fluorescence of specific wavelength, and normal structure do not have this absworption peak or absworption peak very a little less than, and then tumor and normal structure made a distinction.Light power fluorescence diagnosis can be used for the fluoremetry imaging; Can position and the profile of scientific ground quantitative analysis tumor tissues in normal structure; The endoscopic images system acquisition of process system disposition also shows on display screen; For the doctor provides effective fluorescence diagnosing tumor location, optical dynamic therapy and fluorescence diagnosis positioning means are cooperatively interacted reach clinical effectiveness better.
The patent No. is ZL 200720119060.0, the day for announcing to be that the Chinese utility model patent in May 14 in 2008 discloses a kind of optical power therapentic equipment that has the fluorescence diagnosis function; This device comprises kernel control module; And by led array fluorescence excitation light source, led array treatment light source and the image capture module of kernel control module control; As shown in Figure 1; Said led array fluorescence excitation light source, led array treatment light source and image capture module can all be integrated in the operating head 32, diagnose or treat through this operating head 32.This device does not combine endoscope apparatus, promptly can only treat and diagnoses skin surface lesion surface tissue.This has limited optical dynamic therapy to a certain extent in the body cavity cancer therapeutic applications.
Application number is 200710073605.3; The Chinese invention patent application that open day is on JIUYUE 24th, 2008 also discloses a kind of optical power therapentic equipment; This device does not combine endoscope apparatus yet; And optical fiber interface can only be selected output treatment light source or excitation source, and this not only influences therapeutic effect, and the configured light sources mode has also limited the range of application of optical dynamic therapy.
The equipment of core is high power semiconductor lasers in the PDT; Treating the 630nm laser instrument of optical fiber connector output greater than 2W is a present technical bottleneck both domestic and external; Because 630nm wavelength single die output power is below 200-300mW at present; And the luminous power that final system requires is less than or equal 10W (considering under the situation of each grade coupled and loss), even higher luminous power.Can only adopt some special optical polarizations to cut apart coupling technique synthesize the output of the crust bar of a plurality of laser dies encapsulation with the bigger luminous power of acquisition.As shown in Figure 2, general coupled modes are that the tube core of each laser instrument is coupled respectively to single small-bore optical fiber, form the bundle that closes through output optical fibre A2 output by many small-bore optical fiber then.Laser instrument for this mode;, optical fiber connector needs a plurality of laser instrument series connection or parallel connection when need reaching than macro-energy at least; Each laser instrument also will be supplied power separately through Laser Power Devices; Form by many small-bore optical fiber then and close bundle, therefore exist bulky, the output optical fibre core diameter thick, the irregular problem of fiber end face of binding, coupling efficiency low and operational failure rate height and defect of high cost.
When the treatment tumor adopts photodynamic therapy on clinical medicine, follow light power fluorescence diagnosis location simultaneously, must this three kinds of light sources be arranged indispensability as the means of diagnosing, observing; Photodynamic therapy is located with excitation source, endoscope-use lighting source with treatment light source, light power fluorescence diagnosis.And at present be autonomous device at the light source of optical dynamic therapy, fluorescence diagnosis and endoscope illumination; On the technical scheme that realizes optical dynamic therapy, fluorescence diagnosis, adopt OPK treatment light source and diagnosis excitation source to insert the biopsy mouth passage of endoscope as carrier by optical fiber separately respectively; Carry out photodynamic therapy and light power fluorescence diagnosis location to the body cavity tumor locus; And entering into tumor locus by the leaded light interface channel of endoscope, lighting source throws light on; Complicated on technical scheme realizes, equipment disperses, and cost is higher.In addition; Because the aperture of the biopsy mouth passage of endoscope is less, treatment light source and excitation source all adopt the transport vehicle of the little optical fiber of numerical aperture as light, the bigger tumor in body cavity space are being treated when locating with fluorescence diagnosis; The hot spot of treatment and fluorescence diagnosis is less; Can not satisfy the demand of tumor (like gastric cancer, bladder cancer etc.) area, need repeatedly carry out the treatment of segmentation or multiple spot, can cause treatment time long (ordinary circumstance surpasses more than 1 hour) like this than the illuminating area of the situation of big and intracavity multiple spot tumor; As far as high-risk group's patient, there is very big risk especially.The bad control of the dosage of patient in treatment, also there are many defect problems in many shortcomings such as operation inconvenience in clinical practice.
Summary of the invention
The objective of the invention is to solve the problem that exists in the prior art, a kind of optical dynamic therapy and fluorescence diagnosis navigation system are provided.
Technical scheme of the present invention is: a kind of optical dynamic therapy and fluorescence diagnosis navigation system comprise optical power therapentic equipment, multipurpose LED medical light source system, image collecting device and analysis process system and kernel control module group; It is characterized in that: said kernel control module group is controlled said optical power therapentic equipment output treatment light source according to optical dynamic therapy, the localized requirement of fluorescence diagnosis, and excitation source, lighting source or the wavelength that said kernel control module group control multipurpose LED medical light source system selects output to be used to carry out fluorescence diagnosis is different from the LED treatment light source of said treatment light source;
The treatment light source of said optical power therapentic equipment output directly carries out body surface place optical dynamic therapy, perhaps carries out optical dynamic therapy by optic fibre carrier through the focus zone of the biopsy mouth arrival patient's body lumen of endoscope; The output light source of said multipurpose LED medical light source system directly carries out fluorescence diagnosis location, body surface place or optical dynamic therapy, perhaps carries out fluorescence diagnosis location, illumination or optical dynamic therapy in the guide lighting channel entering patient body through said endoscope; And,
Said optical dynamic therapy and fluorescence diagnosis navigation system also comprise image collecting device and the analysis process system that is connected with the kernel control module communication; Said image collecting device and analysis process system comprise image collecting device and graphical analysis, processing and medical record management module and collection lens; Said collection lens is the view data that image collecting device and analysis process system are gathered patient's body lumen focus zone through the objective of endoscope interface; Perhaps gather the view data in body surface focal zone territory, said image collecting device and analysis process system carry out image analysis to the view data that collects.
Preferably; Said optical power therapentic equipment comprises the semiconductor laser module that has multiple detecting sensor and protector; Said semiconductor laser module comprises semiconductor laser element and the optical module system that is used to produce the treatment light source; Said semiconductor laser element is installed on the substrate; Said optical module system comprises optical focus mirror group, polarizing coupler, fast slow axes collimating module, and said optical module system is arranged on the emitting light path axis of semiconductor laser element, and to be laser that semiconductor laser is produced focus on the central shaft of launching in the joints of optical fibre that are used to connect said optical fiber through this optical module in effect; Guarantee simultaneously when said optical fiber is screwed onto the joints of optical fibre, can focus on the fiber optic hub end face; The wave-length coverage of said semiconductor laser module is 350～800nm, and Output optical power is less than or equal to 10W.
Preferably; Said semiconductor laser module also comprises the luminous reflectance feedback window; It is arranged on branch's light path of polarizing coupler; Its effect be laser in transmission course, when laser-bounce, reflex to this luminous reflectance feedback window, for the outside provides laser-bounce feedback through polarizing coupler.
Preferably, said semiconductor laser module also comprises replaceable protection window, and it is installed between the said optical module system and the joints of optical fibre.
Preferably, be provided with optical fiber in the passage of the said joints of optical fibre and insert detecting sensor and optical fiber interface temperature sensor; Said substrate is provided with the temperature sensor that is used to detect the semiconductor laser module actual work temperature, for thermostatic control and overtemperature alarm provide the temperature detection sampled signal; Said substrate is provided with the optical power sensor that is used to detect actual light power in the position of the emergent light of semiconductor laser element, for the outside provides laser power feedback sample signal.
Preferably, said multipurpose LED medical light source system comprises the multi-wavelength LED light source, and as the endoscope's cold light source or the LASER Light Source of said lighting source; Said kernel control module group is controlled excitation source or the LED treatment light source that said multi-wavelength LED light source is exported required wavelength, perhaps exports the led light source as said lighting source; The output of said kernel control module group control endoscope's cold light source or LASER Light Source; The output of said multi-wavelength LED light source and endoscope's cold light source or LASER Light Source inputs to two inputs of bundling device respectively, and the outfan of said bundling device connects on the guide lighting channel of endoscope when body cavity is used.
Preferably, said multi-wavelength LED light source is integrated with the single chip LED light-emitting substrate that is controlled by said kernel control module group, and perhaps multi-disc has the LED light-emitting substrate of identical wavelength or different wave length; Said multi-wavelength LED light source also comprises optical focus assembly and actuator; Said LED light-emitting substrate is fixed on the fixing head; Said actuator is the motion of drive fixing head under the control of kernel control module group; The emission light center point of the LED light-emitting substrate of the required wavelength on the fixing head is moved on the incident illumination axis of said optical focus assembly, the shaping of the light beam process optical focus assembly of the LED light-emitting substrate that motion puts in place and the input that focussed collimated outputs to said bundling device.
Preferably; Said LED light-emitting substrate is by single led chip; Perhaps be made up of the led chip array of several identical wavelength or different wave length, the wave-length coverage of said led chip generally adopts 350nm～2200nm, and perhaps said led chip is that colour temperature is the White-light LED chip of 6000-6500k.
The invention has the beneficial effects as follows: the semiconductor laser module that the providing of optical dynamic therapy according to the invention and fluorescence diagnosis navigation system has multiple detecting sensor and protector and multipurpose LED medical light source system, image collecting device and analysis process system through endoscope's Application of Interface in body surface and the treatment of intracoelomic cavity road photodynamic tumor, the localized technical barrier that becomes one of fluorescence diagnosis.
The light source configuration of optical dynamic therapy according to the invention and fluorescence diagnosis navigation system presents variation; Relevance grade is wide; For example; Can the treatment that be suitable for treating light source can be provided through optical power therapentic equipment, also can be provided for carrying out the localized excitation source of fluorescence diagnosis, endoscope illumination light source or LED treatment light source through the multipurpose LED medical light source system.
Optical dynamic therapy according to the invention and fluorescence diagnosis navigation system have following function concurrently, at first, observe for the treatment of tract class tumor or precancerous lesion provides the endoscope real time of overall process to detect in operation; Secondly; Carry out the fluorescence diagnosis location through the multipurpose LED medical light source system before the optical dynamic therapy; Scientifically to analysis and the judgement of tumor tissues before treating, and then start optical power therapentic equipment or the multipurpose LED medical light source system carries out optical dynamic therapy to tumor or precancerous lesion tissue; At last; Be equipped with image collecting device to carry out image analysis and analysis, processing and synthetic; Can carry out literal and image recording, analyzing and processing and statistics to whole therapeutic process; And support to print medical record etc., realize before and after the treatment the following up a case by regular visits to of oncotherapy effect, the assessment of clinical efficacy science and the residual early discovery of tumor.Therefore, optical dynamic therapy according to the invention and fluorescence diagnosis navigation system help improving the intelligent of equipment and Image Information Processing level, strengthen the science of optical dynamic therapy, have also reduced OPK treatment cost and equipment Operating Complexity simultaneously.
Description of drawings
Fig. 1 a is the structural representation of existing a kind of optical power therapentic equipment;
Fig. 1 b is a kind of enforcement structure of existing high power semiconductor lasers;
Fig. 2 is the structural representation of optical dynamic therapy according to the invention and fluorescence diagnosis navigation system;
Fig. 3 is the structural representation of optical power therapentic equipment shown in Figure 2;
Fig. 3 a is the structure side view of the critical piece semiconductor laser element of semiconductor laser module shown in Figure 3;
Fig. 3 b is the structural perspective of the critical piece semiconductor laser element of semiconductor laser module shown in Figure 3;
Fig. 3 c shows the electrical connection of semiconductor laser module shown in Figure 3;
Fig. 3 d is the inside critical piece and the sensor signal lead-in wire connection layout of semiconductor laser module shown in Figure 3.
Fig. 3 e is the optical principle of semiconductor laser module employing shown in Figure 3 and three kinds of applicating examples of practical implementation.
Fig. 4 is the structural representation of multipurpose LED medical light source system shown in Figure 2;
Fig. 5 is the application sketch map of optical dynamic therapy shown in Figure 2 and fluorescence diagnosis navigation system.
The specific embodiment
Below in conjunction with accompanying drawing the present invention is described further.
As shown in Figure 2; Optical dynamic therapy according to the invention and fluorescence diagnosis navigation system comprise kernel control module group 70; Optical power therapentic equipment 10, multipurpose LED medical light source system 20 and the image collecting device and the analysis process system 30 that all are connected with said kernel control module group 70 communications, and can also comprise the output device 60 that is connected with said image collecting device and analysis process system 30 communications.
Said optical power therapentic equipment 10 adopts the semiconductor laser module 10a that has multiple detecting sensor and protector shown in Fig. 3 a to 3d.In the present embodiment; As shown in Figure 3, said optical power therapentic equipment 10 comprises treatment controller 19, the semiconductor laser module 10a with multiple detecting sensor and protector, semiconductor chilling plate 10b, laser drive power 13, precision temperature intelligence control circuit and cooling system 14, laser power detection and laser-adjusting unit 15, treatment display setting device 16, interlocking switch 17 and foot switch 18 etc.The characteristics of said optical power therapentic equipment 10 are said semiconductor laser module 10a.
Shown in Fig. 3 d; The critical piece of this semiconductor laser module 10a is for being used for lasing semiconductor laser element 100a; This semiconductor laser element 100a comprise one heat sink be semiconductor laser anodal 104; Be crimped on this isolated semiconductor laser negative pole 103 of mutual electricity on heat sink, and be arranged at the semiconductor laser tube core chip array 102 on the semiconductor laser anodal 104.This semiconductor laser anodal 104 can be the alloyed copper layer, and the heat that the assurance laser instrument is produced in running is by this heat sink conduction.The negative pole of semiconductor laser tube core chip is welded to above the semiconductor laser negative pole 103 or the direct surface crimping through the gold thread wire drawing; Semiconductor laser anodal 104 is fixed to substrate 100 with semiconductor laser negative pole 103 through copper stud a13, copper stud a14 extension; Use working of plastics to guarantee the good insulation between positive-negative polarity simultaneously, copper stud a14 and copper stud a13 are as the external power source both positive and negative polarity input terminal of semiconductor laser module 10a power supply.A is laser beam and the direction that semiconductor laser tube core chip array 102 penetrates.
The production method of this semiconductor laser element 100a is following: at first screen the semiconductor laser tube die chip, and heat sink with gold-plated cuboid as intermediate carrier, after this; With the mode of full wafer vapor deposition scolder on heat sink, utilize the scolder semiconductor laser tube core chip that in each heat sink unit, bonds, after finishing, bonding puts into alloying furnace together; Adopt golden tin solder, sintering is 10 seconds～60 seconds under 280 ℃～300 ℃ and logical nitrogen protection condition, and the heat sink unit that is stained with chip behind the sintering is cut down from heat sink of full wafer; Utilize the single array arrangement of silver slurry to be bonded on the alloyed copper layer plane edge; Bonding gold thread on the N of semiconductor laser tube core chip face electrode connects gold thread on the negative electrode pin, and the alloyed copper layer is as positive pole; Adopt parallel connected array to arrange between the chip, quantity can single or a plurality of parallel connections.This semiconductor laser element 100a wave-length coverage is 350～800nm.
Said semiconductor laser element 100a is installed on the substrate 100; The position that this substrate 100 closes on this semiconductor laser element 100a is provided with temperature sensor a20; This temperature sensor a20 is used to detect the actual work temperature of semiconductor laser element 100a, for thermostatic control and overtemperature alarm provide the temperature detection sampled signal; This substrate 100 is provided with optical power sensor a30 in the outgoing position of semiconductor laser element 100a, and its effect is the actual light power that detects semiconductor laser element 100a, for the outside provides laser power feedback sample signal.Said semiconductor laser module 10a is coupled through the laser that the a80 of optical module system noise spectra of semiconductor lasers unit 100a sends; The a80 of this optical module system comprises optical focus mirror group 87, polarizing coupler 88 and fast slow axes collimating module 89; Shown in Fig. 3 d and 3e; The said optical module a80 of system is arranged on the emitting light path axis of semiconductor laser element 100a, and effect is that the laser that semiconductor laser element 100a produces is launched on the central shaft of joints of optical fibre a40 through the focusing of this optical module system, guarantees when optical fiber 11 is screwed onto joints of optical fibre a40 simultaneously; Can focus on the fiber optic hub end face; Reach maximum light transmissioning efficiency, the applicating example of Fig. 4 e signal can see, the laser beam of launching from semiconductor laser tube core; After collimating, arrange, focus on transformation through the optical module a80 of system; Be coupled to joints of optical fibre a40 central shaft to focus, when optical fiber 11 is connected this focus through joints of optical fibre a40, guarantee that laser energy on this focus converges at optical fiber 11 center end faces and overlaps.This method is than the laser instrument of light beam (Bundle) output form output, arrayed encapsulation between laser tube core that can parallelly connected greater number and tube core, and great advantage is: high power, small size; Also integrated pilot light light source a11 in substrate 100 simultaneously; The light that pilot light is launched gets into polarizing coupler 88 through 86 reflections of mirror group; Can be coupled into simultaneously in the optical fiber 11 with semiconductor laser element institute emitted laser through focus lamp group 87 at last, this pilot light light source has the important function of targeting location and treatment guide in the medical operating process.Joints of optical fibre a40 can be SMA or FC interface, and polarizing coupler 88 is 45 ° of installations with mirror group 86.
In joints of optical fibre a40 passage, be provided with optical fiber and insert detecting sensor a50 and optical fiber interface temperature sensor a60; Whether be used for detecting outfan optical fiber is connected bad or comes off; And the temperature that therefore interface causes is too high; And handle to the control system in the equipment the detected signal feedback, guarantee the maximum transmitted efficient of semiconductor laser module 10a and move safely.These two pick offs are that the effective transmission of laser instrument provides detection signal, have protected semiconductor laser module 10a better.
Replaceable protection window a70 is installed on joints of optical fibre a40 rear end; Main effect is for when frequently connecting optical fiber 11; Foreign body and dust very easily get in the optical module a80 of the system cavity through joints of optical fibre a40 passage, have hindered axial optics transmission channel, have a strong impact on efficiency of transmission.Can guarantee cavity and outside effective isolation with this protection window; Its two, for pollution face is cleaned and changes, this protection window is the Embedded substrate 100 that is fixed in, and is for convenience detach and change.
Luminous reflectance feedback window a90 is arranged on branch's light path of polarizing coupler 88; Its effect be at laser in transmission course; Reflex to this luminous reflectance feedback window owing to the outside cause reflex time through polarizing coupler 88 as laser, for the outside provides the laser-bounce light signal fed back.Make things convenient for control system to detect and control with this function.
Whole module adopts sealed package, and inside is filled with nitrogen, and purpose is in order to prevent under refrigerating effect semiconductor laser owing to the temperature difference produces the dewfall phenomenon, thereby damages laser instrument in the course of the work.
Described semiconductor laser element 100a can adopt single or array arrangement directly is welded on the heat sink laser strip that goes up.
It can be mechanical or photo-electric that described optical fiber inserts acquisition sensor.
Described laser tube temperature pick off is negative tempperature coefficient thermistor (NTC) or semistor (PTC).
Described optical power sensor is the electro-optical pickoff of photodiode (PD) type.
Described pilot light light source is that wave-length coverage is LASER Light Source or the led light source of 350～800nm.
Said signal line interface a12 is used to realize that each several part is connected with the communication of treatment controller 19.
All semiconductor laser tube core chips of said semiconductor laser element 100a can need not to supply power separately through said laser drive power 13 unified power supplies.With respect to the coupled modes of explaining in the background technology, the advantage of this kind coupled modes is: the volume of laser instrument is little, output is high, coupling efficiency is high, spot diameter is little, good stability, is prone to drive and control.Said semiconductor laser module 10a is through semiconductor chilling plate 10b attemperation; Said precision temperature intelligence control circuit and cooling system 14 are gathered the temperature signal of semiconductor chilling plate 10b cold junction; And with this temperature signal be delivered to the treatment controller 19 handle; Treatment controller 19 makes the operating temperature of the semiconductor laser module 10a that has multiple detecting sensor and protector keep constant according to the output of process result control semiconductor chilling plate 10b.
Said optical power therapentic equipment 10 generally is used for producing the treatment light source.
When carrying out the body cavity treatment, said optical dynamic therapy and fluorescence diagnosis navigation system also should comprise the endoscope 50 shown in Fig. 2 and 5, and said endoscope 50 has biopsy mouth 51, guide lighting channel 52 and object lens interface 53.In carrying out body during optical dynamic therapy, the optical fiber 11 of optical power therapentic equipment 10 is inserted to the tumor focus zone of intracavity from the biopsy mouth 51 of endoscope, the treatment light source will be radiated at diseased region through optical fiber 11 and carry out optical dynamic therapy.Certainly, the treatment light source of said optical power therapentic equipment 10 outputs also can directly carry out the optical dynamic therapy at body surface place.
As shown in Figure 4; Said multipurpose LED medical light source system 20 is used to produce fluorescence diagnosis excitation source, lighting source and LED treatment light source; Therefore, said multipurpose LED medical light source system 20 comprises multi-wavelength LED light source 210, actuator 221, optical focus assembly 230, bundling device 260 and can select light source 240.Said multi-wavelength LED light source 210 comprises fixing head 211 and is fixed on the LED of a slice at least light-emitting substrate 212 on the fixing head 211; Every LED light-emitting substrate 212 can be packaged with single led chip; Also can form by the led chip array of several identical wavelength or different wave length; The wave-length coverage of said led chip is typically chosen in 375nm～2200nm, and said led chip also can be that colour temperature is the White-light LED chip of 6000-6500k, at this; The LED light-emitting substrate 212 of various wavelength forms can be provided according to demand, and LED light-emitting substrate 212 is being arranged on the fixing head 211 on the fixing head 211 in some way.Said actuator 221 can drive fixing head 211 motions; The emission light center point of the arbitrary LED light-emitting substrate 212 on the fixing head 211 is moved on the incident illumination axis of said optical focus assembly 230, and the light beam of LED light-emitting substrate 212 outputs to said bundling device 260 through the shaping and the focussed collimated of optical focus assembly 230.
The said light source 240 of selecting can be endoscope's cold light source or LASER Light Source; At this; Can select according to the actual requirements; The outfan of said optical focus assembly 230 links to each other with an input of bundling device 260, and the said light source of selecting links to each other with another input of bundling device 260, and the outfan of bundling device 260 can connect the carrier of transmission light such as optical fiber or light guide bundles 23 through adapter 270.Therefore; But export light that a certain LED light-emitting substrate 212 sends and can select light source 240 through said bundling device 260 timesharing; Perhaps export light that a certain LED light-emitting substrate 212 sends and can select the formed bundle that closes of light source, synthesize the light source that can form another kind of required wavelength like a kind of led light source and LASER Light Source of wavelength.
Said multipurpose LED medical light source system 20 can dispose core control devices 250; Said core control devices 250 can be carried out communication through communication interface and kernel control module group 70; Therefore; Can assign instruction through kernel control module group 70; Make core control devices 250 control multi-wavelength LED light sources 210 and the output situation that can select light source 240, using this multipurpose LED medical light source system 20 separately, again can be through the preset instructions control multi-wavelength LED light source 210 and the output situation that can select light source 240 of core control devices 250.Said core control devices 250 drives multi-wavelength LED light sources 210 through driving device 222 control executing mechanism 221 and moves to the desired position, wherein motion command can come from kernel control module group 70 or when using separately from the preset instructions of core control devices 250.In this embodiment; The LED light-emitting substrate 212 of multi-disc different wave length all is fixed on the front of fixing head 211; Said optical focus assembly 230 is towards the front of fixing head 211; And make the positive vertical of its incident illumination axis and fixing head 211, like this, in the plane at its place, move the emission light center point of the arbitrary LED light-emitting substrate 12 on it is moved on the incident illumination axis of said optical focus assembly 230 as long as actuator 221 drives fixing heads 211.
For LED light-emitting substrate 212 can be operated under the temperature constant state as far as possible; Said multi-wavelength LED light source 210 also comprises the LED chiller 213 that is packed on the fixing head 211; In the present embodiment; All LED light-emitting substrates 212 all are fixed on the front of fixing head 211, and said LED chiller 13 then is packed on the back side of fixing head 11.Described LED chiller 13 can comprise the radiator of thermoelectric refrigerator, temperature sensor and band radiator fan; The cold junction of said thermoelectric refrigerator is affixed on the back side of fixing head 211; The hot junction of said thermoelectric refrigerator links to each other with radiator; And then the heat that the hot junction produced of thermoelectric refrigerator is shed through air cooling way, said temperature sensor can detect the temperature of fixing head 211 in real time.
As medical light source, the wavelength of encapsulated LED chip can be purple light 375nm, blue light 470nm, HONGGUANG 630nm and HONGGUANG 670nm on the said LED light-emitting substrate 212, and peak power is 10～100W; Also can be blue light 405nm, HONGGUANG 630nm, green glow 532nm and near infrared light 780nm, peak power is 5～50W; Can also for colour temperature the White-light LED chip of 6000-6500k.
Therefore; Can timesharing export light beam and the cold light source 24g of endoscope that arbitrary LED light-emitting substrate forms through said bundling device 260; The said colour temperature that is packaged with is that white light and the endoscope's cold light source of LED light-emitting substrate 212 output of the White-light LED chip of 6000-6500k all can be used as lighting source; Can select according to practical situation during application; The led light source of other various wavelength can be used as the fluorescence diagnosis excitation source, during application need according to employed photosensitizer select for use adapt to the led light source of wavelength, be suitable for as the LED treatment light source that needs the large spot area like said HONGGUANG 630nm and HONGGUANG 670nm etc.
For the ease of man-machine interaction; Optical dynamic therapy according to the invention and fluorescence diagnosis navigation system comprise that also the demonstration that is connected with 70 communications of kernel control module group is provided with module 90; Through demonstration the running parameter that module 90 can be provided with multipurpose LED medical light source system 20 is set, and shows the duty of multipurpose LED medical light source system 20 in real time.
Said image collecting device and analysis process system 30 comprise image collecting device and graphical analysis, processing and medical record management module, and said image collecting device disposes the collection lens that is used for acquisition of image data.The collection lens of image collecting device and analysis process system 30 is connected on the object lens interface 53; Open image collecting device and analysis process system 30 through kernel control module group 70; Control the white light that multipurpose LED medical light source system 20 output is sent as the endoscope's cold light source or the LED light-emitting substrate 212 of lighting source simultaneously, image analysis module will be carried out image analysis to the general image data that collection lens collects; When needs carry out fluorescence analysis to lesions position; Collection lens with image collecting device and analysis process system 30 is connected on the objective of endoscope interface 53 equally; When opening image collecting device and analysis process system 30 through kernel control module group 70; Control multipurpose LED medical light source system 20 output simultaneously as excitation source and the led light source used photosensitizer of fluorescence diagnosis institute matching wavelengths, image analysis module will be carried out image analysis to the fluoroscopic image data that collection lens collects.Said image processing module is to further handling through the general image data and/or the fluoroscopic image data of resolving, and is last, through output device 60, shows output like display and printer etc.Simultaneously, can also directly print medical record through printer by medical record management module editor.
As shown in Figure 5; The interior therapeutic technical scheme of optical dynamic therapy according to the invention and fluorescence diagnosis navigation system is: through the biopsy mouth 51 input treatment light sources of endoscope; And the method for utilization " time-sharing multiplex "; Guide lighting channel 52 timesharing input excitation source, lighting source or LED treatment light source through an endoscope; In guide lighting channel 52 when focus zone the import excitation source just fluorescence excitation reaction of multipurpose LED medical light source system 20 through endoscope, tumor tissues B and normal structure D are on every side divided open, confirm just can carry out optical dynamic therapy behind the concrete lesions position.
In addition; Through said demonstration module 90 is set working condition can be set; Make the kernel control module group 70 can be, and show module 90 displaing core control module group 70 residing duties in real time are set according to the preset corresponding control model of procedure Selection.
The power module (not shown) of said optical dynamic therapy and fluorescence diagnosis navigation system inserts the 220V civil power; And be converted into the needed running voltage of each ingredient of optical dynamic therapy and fluorescence diagnosis navigation system, be each ingredient power supply through power module.
Being merely preferred embodiment of the present invention in sum, is not to be used for limiting practical range of the present invention.Be that all equivalences of doing according to the content of claim of the present invention change and modification, all should belong to technological category of the present invention.
Claims (6)
1. optical dynamic therapy and fluorescence diagnosis navigation system comprise optical power therapentic equipment, multipurpose LED medical light source system, image collecting device and analysis process system and kernel control module group; It is characterized in that: said kernel control module group is controlled said optical power therapentic equipment output treatment light source according to optical dynamic therapy, the localized requirement of fluorescence diagnosis, and excitation source, lighting source or the wavelength that said kernel control module group control multipurpose LED medical light source system selects output to be used to carry out fluorescence diagnosis is different from the LED treatment light source of said treatment light source;
The treatment light source of said optical power therapentic equipment output directly carries out body surface place optical dynamic therapy, perhaps carries out optical dynamic therapy by optic fibre carrier through the focus zone of the biopsy mouth arrival patient's body lumen of endoscope; The output light source of said multipurpose LED medical light source system directly carries out fluorescence diagnosis location, body surface place or optical dynamic therapy, perhaps carries out fluorescence diagnosis location, illumination or optical dynamic therapy through the guide lighting channel entering patient's body lumen of said endoscope; And,
Said image collecting device and analysis process system are controlled by the kernel control module group; Said image collecting device and analysis process system comprise image collecting device and graphical analysis, processing and medical record management module, and said image collecting device disposes collection lens; Said collection lens is the view data that image collecting device and analysis process system are gathered patient's body lumen focus zone through the objective of endoscope interface; Perhaps gather the view data in body surface focal zone territory, said image collecting device and analysis process system carry out image analysis to the view data that collects;
Said multipurpose LED medical light source system comprises the multi-wavelength LED light source, and as the endoscope's cold light source or the LASER Light Source of said lighting source; Said kernel control module group is controlled the excitation source or the LED treatment light source that are used to carry out fluorescence diagnosis that said multi-wavelength LED light source is exported required wavelength, perhaps exports the led light source as said lighting source; The output of said kernel control module group control endoscope's cold light source or LASER Light Source; The output of said multi-wavelength LED light source and endoscope's cold light source or LASER Light Source inputs to two inputs of bundling device respectively, and the outfan of said bundling device connects on the guide lighting channel of endoscope when body cavity is used;
Said multi-wavelength LED light source is integrated with the single chip LED light-emitting substrate that is controlled by said kernel control module group, and perhaps multi-disc has the LED light-emitting substrate of identical wavelength or different wave length; Said multi-wavelength LED light source also comprises optical focus assembly and actuator; Said LED light-emitting substrate is fixed on the fixing head; Said actuator is the motion of drive fixing head under the control of kernel control module group; The emission light center point of the LED light-emitting substrate of the required wavelength on the fixing head is moved on the incident illumination axis of said optical focus assembly, the shaping of the light beam process optical focus assembly of the LED light-emitting substrate that motion puts in place and the input that focussed collimated outputs to said bundling device.
2. optical dynamic therapy according to claim 1 and fluorescence diagnosis navigation system; It is characterized in that: said optical power therapentic equipment comprises the semiconductor laser module that has multiple detecting sensor and protector; Said semiconductor laser module comprises semiconductor laser element and the optical module system that is used to produce the treatment light source; Said semiconductor laser element is installed on the substrate; Said optical module system comprises optical focus mirror group, polarizing coupler, fast slow axes collimating module; Said optical module system is arranged on the emitting light path axis of semiconductor laser element; To be laser that semiconductor laser is produced focus on the central shaft of launching in the joints of optical fibre that are used to connect said optical fiber through this optical module in effect, guarantees simultaneously when said optical fiber is screwed onto the joints of optical fibre, can focus on the fiber optic hub end face; The wave-length coverage of said semiconductor laser module is 350～800nm, and Output optical power is less than or equal to 10W.
3. optical dynamic therapy according to claim 2 and fluorescence diagnosis navigation system; It is characterized in that: said semiconductor laser module also comprises the luminous reflectance feedback window; It is arranged on branch's light path of polarizing coupler; Its effect be laser in transmission course, when laser-bounce, reflex to this luminous reflectance feedback window, for the outside provides laser-bounce feedback through polarizing coupler.
4. according to claim 2 or 3 described optical dynamic therapies and fluorescence diagnosis navigation system, it is characterized in that: said semiconductor laser module also comprises replaceable protection window, and it is installed between the said optical module system and the joints of optical fibre.
5. according to claim 2 or 3 described optical dynamic therapies and fluorescence diagnosis navigation system, it is characterized in that: be provided with optical fiber in the passage of the said joints of optical fibre and insert detecting sensor and optical fiber interface temperature sensor; Said substrate is provided with the temperature sensor that is used to detect the semiconductor laser module actual work temperature, for thermostatic control and overtemperature alarm provide the temperature detection sampled signal; Said substrate is provided with the optical power sensor that is used to detect actual light power in the position of the emergent light of semiconductor laser element, for the outside provides laser power feedback sample signal.
6. optical dynamic therapy according to claim 1 and fluorescence diagnosis navigation system; It is characterized in that: said LED light-emitting substrate is by single led chip; Perhaps form by the led chip array of several identical wavelength or different wave length; The wave-length coverage of said led chip generally adopts 350nm～2200nm, and perhaps said led chip is that colour temperature is the White-light LED chip of 6000-6500k.
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