CN101862364A - Preparation method of traditional Chinese medicinal extract of Chinese angelica and red flower and series preparations thereof - Google Patents
Preparation method of traditional Chinese medicinal extract of Chinese angelica and red flower and series preparations thereof Download PDFInfo
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- CN101862364A CN101862364A CN 201010127401 CN201010127401A CN101862364A CN 101862364 A CN101862364 A CN 101862364A CN 201010127401 CN201010127401 CN 201010127401 CN 201010127401 A CN201010127401 A CN 201010127401A CN 101862364 A CN101862364 A CN 101862364A
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- radix angelicae
- angelicae sinensis
- flos carthami
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Abstract
The invention relates to a preparation method of a traditional Chinese medicinal extract of Chinese angelica and red flower. The traditional Chinese medicinal extract is prepared by taking natural traditional Chinese herbal medicines of the red flower and the Chinese angelica as raw material medicines by the weight ratio of 1:0.5-1:5 and comprising the following steps of: (1) taking the red flower and the Chinese angelica and soaking with proper solvent; (2) respectively extracting 1-4 times with water by the ratio of 1:5-1:20 and decocting for 0.5-3 hours for each time; and (3) combining extraction liquid, decompressing and condensing to the volume equivalent to 1:0.5-1:4 of the crude medicine, and then pouring and filtering to obtain the traditional Chinese medicinal extract of the Chinese angelica and the red flower. The invention confirms the unique therapeutic effects of the Chinese angelica and the red flower on the aspect of treating cardiovascular and cerebrovascular diseases. Since the Chinese angelica and the red flower have remarkable advantages on improving and treating the cardiovascular and cerebrovascular diseases, the invention applies the Chinese angelica and the red flower in a combination way and prepared water extracts of the Chinese angelica and the red flower into certain preparations suitable for large industrial production so as to meet the medication requirements of mass patients.
Description
Technical field:
The present invention relates to the preparation method of Chinese medicine extract, relate in particular to a kind of preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract.
Background technology:
Radix Angelicae Sinensis is a kind of herbaceos perennial of Umbelliferae angelica.Its exsiccant storage root is China's Chinese crude drug commonly used simply.Radix Angelicae Sinensis and compound preparation thereof are mainly used in treatment cardiovascular disease and gynaecopathia clinically, as anti-arrhythmia, acute ischemic apoplexy, cerebral arteriosclerosis and menstruation disease, uterine prolapse etc.Radix Angelicae Sinensis is widely used for treatment chronic hepatitis, upper gastrointestinal hemorrhage and migraine, neurosis headache, muscle Joint neuralgia, dermatosis and scapulohumeral periarthritis in addition.
The medical value of Flos Carthami is high, and its Seedling, fruit all can be used as medicine, nature and flavor suffering, temperature.Has promoting blood circulation to restore menstrual flow, the effect of stasis-dispelling and pain-killing.Modern medicine and pharmacology studies show that Flos Carthami contains Carthamus yellow and carthamin, and still fatty oil also claims safflower oil, is the glycerolipid of Palmic acid, stearic acid, arachidic acid, oleic acid, linoleic acid, linolenic acid etc.The excited uterus of pharmacological evaluation proof Flos Carthami energy, coronary artery dilator and femoral artery can reduce total cholesterol in the blood, total ester, glyceryl trinitrate and non-esterified fatty acid level, smooth muscle such as the excited small intestinal of safflower oil energy, bronchus.
Summary of the invention:
The objective of the invention is to overcome the preparation method that the prior art defective provides a kind of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract.
The present invention realizes according to following proposal:
The preparation method of a kind of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract and preparation series thereof is a crude drug with Flos Carthami, Radix Angelicae Sinensis natural Chinese medicinal herb, and its weight ratio is: 1: 0.5～1: 5, follow these steps to preparation:
(1) gets Flos Carthami and Radix Angelicae Sinensis, soak with appropriate solvent;
(2) get indescribably 1～4 time with 1: 5～1: 20 moisture, decocted 0.5～3 hour at every turn;
(3) merge extractive liquid, when being evaporated to 1: 0.5～1: 4 volume that is equivalent to crude drug, is toppled over, and filters, promptly;
The described appropriate solvent of step (1) is one or more mixture of forming with certain proportion of water, ethanol, n-butyl alcohol, methanol, ethyl acetate and above each solvent;
The concentrating under reduced pressure temperature is 30～80 ℃ described in the step (3), and vacuum is more than the 740mmHg;
Behind the concentrating under reduced pressure, medicinal liquid is equivalent to 1: 1～1: 2 volume of crude drug described in the step (3), and every 1ml is equivalent to 1～2g medical material;
The said extracted thing can be made any medicament of acceptable clinically in pharmaceutic adjuvant.
Chinese medicine extract of the present invention can be applied to the patient by the mode of oral, rectum or parenteral.Be used for when oral, can be made into conventional solid orally ingestible such as tablet, capsule, powder, granule etc., make other liquid preparations of liquid preparation such as water or oil-suspending agent such as syrup, mixture, tincture etc.; When being used for parenteral, can be made into solution, powder pin, water or the oily suspensions etc. of injection.The preferred mode of the present invention is tablet, capsule, granule, mixture, tincture, powder pin and injection.
The use amount of Chinese medicine extract of the present invention and medicament thereof can be according to variations such as the type of route of administration, patient age, body weight, the disease of being treated and the orders of severity, it can be 1～1g/kg body weight that its daily dose calculates with Chinese medicine extract, can use by one or many.
On the Chinese medicine history of China's vastness, Radix Angelicae Sinensis and Flos Carthami and other Chinese medicine are used and are used for the treatment of cardiovascular and cerebrovascular disease, see in the ancient prescription repeatly." qi as the commander of blood " reaches the theory of " monarch " according to the traditional Chinese medical science, and in conjunction with clinical test results for many years, the present invention has determined Radix Angelicae Sinensis and the unique curative effect of Flos Carthami aspect the treatment cardiovascular and cerebrovascular disease.Because Radix Angelicae Sinensis and Flos Carthami have the advantage of tangible improvement and treatment cardiovascular and cerebrovascular disease, the present invention unites use with Radix Angelicae Sinensis and Flos Carthami, and the water extract of Radix Angelicae Sinensis and Flos Carthami made dosage form certain, that be suitable for industrialized great production, to satisfy the medication requirement of extensive patients.
The specific embodiment:
Embodiment 1:
Get 2 parts of Radix Angelicae Sinensis, 1 part of Flos Carthami was soaked in water 1 hour, and with 1: 12, moisture was got 2 times indescribably in 1: 10, decocted 1 hour at every turn, and merge extractive liquid, when being evaporated to 1: 1 volume that is equivalent to crude drug, is toppled over filtration, promptly.
Embodiment 2:
Get 3 parts of Radix Angelicae Sinensis, 1 part of Flos Carthami was soaked in water 30 minutes, and with 1: 14: 1: 10: 1: 8 ethanol extracted respectively 3 times, decocted 40 minutes at every turn, and merge extractive liquid, when being evaporated to 1: 2 volume that is equivalent to crude drug, is toppled over filtration, promptly.
Embodiment 3:
Get 3 parts of Radix Angelicae Sinensis, 1 part of Flos Carthami was soaked in water 1 hour, and with 1: 12: 1: 8 50% ethanol water extracted respectively 2 times, decocted 1 hour at every turn, and merge extractive liquid, when being evaporated to 1: 3 volume that is equivalent to crude drug, is toppled over filtration, promptly.
Embodiment 4: the preparation of Chinese medicine extract tablet
Embodiment 1 Chinese medicine extract 20g
Starch 20g
Mannitol 10g
Polyvinylpolypyrrolidone 5g
Make 100
Get the Chinese medicine extract among the embodiment 1, put in the appropriate vessel, add starch and mannitol, mix homogeneously is crossed 18 mesh sieves and is granulated, and 18 mesh sieve granulate are crossed in 40 ℃ of oven dry, add polyvinylpolypyrrolidone, tabletting, promptly.
Embodiment 5: the Chinese medicine extract preparation of soft capsule
Embodiment 2 Chinese medicine extract 20g
Polyethylene glycol 6000 10g
Polyglycerin ester 5g
Make 100
Get embodiment 2 Chinese medicine extract, put in the appropriate vessel, under 40 ℃ of conditions, add down polyethylene glycol 6000 and polyglycerin ester in stirring, after stirring, with gelatin: glycerol: water (1: 1: 0.1) is capsule shells, medicinal liquid is suppressed in capsule shells, promptly.
Claims (5)
1. the preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract and preparation series thereof comprises and gets Flos Carthami and Radix Angelicae Sinensis by mass ratio 1: 0.1～1: 20, follows these steps to preparation:
(1) gets Flos Carthami and Radix Angelicae Sinensis, soak with appropriate solvent;
(2) get indescribably 1～4 time with 1: 5～1: 20 moisture, decocted 0.5～3 hour at every turn;
(3) merge extractive liquid, when being evaporated to 1: 0.5～1: 4 volume that is equivalent to crude drug, is toppled over, and filters, promptly.
2. the preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract according to claim 1 and preparation series thereof is characterized in that: the described appropriate solvent of step (1) is one or more mixture of forming with certain proportion of water, ethanol, n-butyl alcohol, methanol, ethyl acetate and above each solvent;
3. the preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract according to claim 1 and preparation series thereof is characterized in that: the concentrating under reduced pressure temperature is 30～80 ℃ described in the step (3), and vacuum is more than the 740mmHg.
4. the preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract according to claim 1 and preparation series thereof is characterized in that: behind the concentrating under reduced pressure, medicinal liquid is equivalent to 1: 1～1: 2 volume of crude drug described in the step (3), and every 1ml is equivalent to 1～2g medical material.
5. the preparation method of Radix Angelicae Sinensis Flos Carthami Chinese medicine extract according to claim 1 and preparation series thereof is characterized in that: its extract can be made any medicament of acceptable clinically in pharmaceutic adjuvant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010127401 CN101862364A (en) | 2010-03-19 | 2010-03-19 | Preparation method of traditional Chinese medicinal extract of Chinese angelica and red flower and series preparations thereof |
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| CN 201010127401 CN101862364A (en) | 2010-03-19 | 2010-03-19 | Preparation method of traditional Chinese medicinal extract of Chinese angelica and red flower and series preparations thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107019728A (en) * | 2016-02-01 | 2017-08-08 | 重庆百笑医疗设备有限公司 | A kind of nourishing heart moxibustion bar |
| CN110075222A (en) * | 2019-05-17 | 2019-08-02 | 王兴东 | A kind of logical Chinese materia medica preparation of heart and brain |
| CN111544375A (en) * | 2020-05-29 | 2020-08-18 | 广州市博卡利生物科技有限公司 | Gel capable of treating gout and preparation method thereof |
-
2010
- 2010-03-19 CN CN 201010127401 patent/CN101862364A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 《2009年中国药学大会暨第九届中国药师周论文集》 20091123 杨静，杨志福，陈敏纯等 红花当归单煎共煎液中有效成分含量的变化 第1536-1544页 1-5 , 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107019728A (en) * | 2016-02-01 | 2017-08-08 | 重庆百笑医疗设备有限公司 | A kind of nourishing heart moxibustion bar |
| CN110075222A (en) * | 2019-05-17 | 2019-08-02 | 王兴东 | A kind of logical Chinese materia medica preparation of heart and brain |
| CN111544375A (en) * | 2020-05-29 | 2020-08-18 | 广州市博卡利生物科技有限公司 | Gel capable of treating gout and preparation method thereof |
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Application publication date: 20101020 |