CN103768129B - Drug composition for preventing or treating hypertension - Google Patents

Abstract

The invention provides a drug composition for preventing or treating hypertension. The drug composition contains eucommia and mistletoe. The drug composition has a remarkable pressure reducing and stabilizing effect on spontaneously hypertensive rats, and meanwhile has the function of improving hypertensive complications, such as lipid metabolic disease, insomnia, irritability and irascibility.

Description

A kind of prevention or the pharmaceutical composition for the treatment of hypertension

Technical field

The present invention relates to pharmaceutical technology field and in particular to a kind of prevention or treatment hypertension pharmaceutical composition.

Background technology

Hypertension is that one kind is increased with systolic arterial pressure or diastolic pressure（140/90mmHg）The commonly encountered diseases that are characterized and multiple Disease, is caused by multiple environmental factorss, life style and inherited genetic factorss collective effect.According to《Chinese hypertension prevention and control guide in 2010》 Report, China's Prevalence of Hypertension is gradually increasing in recent years, just has 1 to suffer from hypertension in every 5 adults, estimates the whole nation at present At least 200,000,000 populations suffer from high blood pressure disease.And the growth along with the age, Hypertension incidence gradually rises, according to 2002 National residents 270,000 people's nutrition and health survey data of year sanitation Ministry tissue shows, China 60 years old and the high blood of above crowd The prevalence of pressure is 49%, just has 1 people to suffer from hypertension in about every 2 more than 60 years old people.

Hypertension is often accompanied by fat and sugar metabolism disorder, and its pathological lesion can lead to atherosclerosiss, thus causing brain The disease damage of the important vital organs such as apoplexy, occlusive cardiovascular disease and renal failure, is the prehuman important lethal, cause of mesh One of residual cause of disease [Wang Meng it, the Progress in Medication state of hypertension summary, Chinese Medicine guide, 2010,8 (11):45- 47].Research shows, lipid metabolic disorder is the common simultaneous phenomenon of hyperpietic, and blood lipid level is had with blood pressure rank Close, the two merges to exist makes Hypertensive subjects have bigger danger.Therefore hypertension therapeutic should not be limited to reduce blood Pressure itself, more should pay attention to the Comprehensive Control to risk factor, treatment [Chen Qin etc., the high blood particularly to metabolism disorder of blood lipid Pressure and the relation analyses of dyslipidemia, Chinese mistaken diagnosis magazine, 2006,6 (21):4149-4150.].For pneumonia in aged Patient, fat and sugar metabolism disorder and lead to the complication such as hyperlipemia, diabetes situation then more common.Additionally, high blood Pressure patient is often in a bad mood, and unstable, mood is irritated, the symptom such as irritability, hypomnesis, not only reduces the quality of life of patient, Increased risk [Li Jianling etc., the observation of hypertension and nursing, the Chinese modern clinic that patient occurs cerebrovas-cularaccident simultaneously Journal of Nursing Science, 2008,3 (6):522-523.].

Medicine currently used for treatment hypertension mainly has diuretic, beta-blocker, calcium antagonist, angiotensin Converting enzyme inhibitor（ACEI）, angiotensin II receptor inhibitor（ARB）, α receptor blocking agent etc., generally drug combination, But because its course of disease is longer, need to be administered throughout one's life, and chemicalses all have different degrees of untoward reaction and toxic and side effects, common Hypokalemia, insomnia, decreased heart rate, erythra, ageusia, cardiopalmus, ankle swelling etc. [love, antihypertensive drug point Class, untoward reaction and reasonable employment, 2011,8 (8):27-28.].When untoward reaction in Western medicine blood pressure lowering, may if being discontinued at once Hypertension rebound can be led to, Huang Linhong et al. by experimentation prove Western medicine Hydrochlorothiazide and clonidine during being administered to kidney Property Hypertensive Rats there is hypotensive effect, but after being discontinued 12 hours, [Huang Lin is red etc., Zhenju Jiangya Tablet hypertension rebound phenomenon Impact to renal hypertensive rat blood pressure, XI AN JIAOTONG UNIVERSITY Subject Index (medicine), 2003,24 (6):615-617.].Tang Xing Honor shows to 55 clinical case follow-up investigations, and patient takes Western medicine nimodipine and Captopril Treatment hypertension, drug withdrawal 10 51 are had after it（92.73%）Hypertension rebound in patient, 55 after being discontinued 15 days（100%）All hypertension rebound in patient [Tang Xingrong, warming and recuperating the spleen and kidney ruling by law treatment yang deficiency of spleen and stomache hypertension clinical research, Chinese tcm emergency, 2008,17 (4):440- 442.].

As can be seen here, clinic is still needed badly and sustainable stablized blood pressure lowering, Small side effects and hypertension complication shape is had necessarily The medicine of improvement result.

Chinese medicine hypertension energy treating both the principal and secondary aspects of a disease and poisonous side effect of medicine is less, curative effect persistently, improving symptom, raising Patients ' life quality, stablize curative effect, reverse target organ damage, reduce the aspect such as complication all have uniqueness advantage [Qin Yuwang, Hypertension Chinese medicine therapeutic methods are in progress, Chinese tcm emergency, and 2008,17 (6):833-835].At present, people work out It is largely used to treat the Chinese medicine preparation of hypertension.CN 101618139A disclose a kind of by Radix Salviae Miltiorrhizae, Rhizoma Chuanxiong, Semen Persicae, Radix Angelicae Sinensis, red The Chinese medicine composition of the treatment hypertension of flower, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Radix Ophiopogonis, Fructus Schisandrae Chinensis and Herba Visci etc. ten taste medicinal ingredient composition. CN101214306A, CN 101884674A, CN 101036736A, CN 102274346A individually discloses the medicine containing the Cortex Eucommiae Thing prescription is used for treating hypertension.But the Chinese prescription taste of Chinese medicine number in these patent documentations above-mentioned is all more than 3 tastes, or even 10 tastes More than, and the prescription of excessive flavour of a drug number is unfavorable for illustrating the prescription advantage of pharmaceutical composition, also increases drug industries simultaneously The difficulty of quality control in big production.

Cortex Eucommiae resisting hypertension has been widely studied and has approved, its mechanism of action is mainly the diastole effect of human peripheral blood pipe, Due to the limitation of single medicine mechanism, people are studied with other drug matchings treatment hypertension to the Cortex Eucommiae.For example yellow Will is new et al., to the Cortex Eucommiae:Herba Visci（Crude drug amount ratio）=1:1 pharmaceutical composition carried out blood pressure lowering research [Huang Zhixin, several The hypotensive activity of taste Chinese medicine and studies on acute toxicity, Shanghai Communications University's Master's thesis, 2002:28-32.].By it is straight Connect after decoction to renal hypertensive rat gastric infusion, this medicament composing prescription of its data display（The crude drug Cortex Eucommiae:Herba Visci=1:1）Tool There is certain antihypertensive effect, but experimental rat has the phenomenon of fluctuation of blood pressure and emotion agitation in administration process；More bright Aobvious is that rat blood pressure substantially significantly gos up after this medicine is discontinued, and illustrates that this drug ratio prescription continues antihypertensive effect relatively Difference, voltage regulation result is undesirable.

It can be seen that, provide one kind can effectively blood pressure lowering, again can after drug withdrawal continue voltage stabilizing, toxic and side effects are little, and are suitable for Chinese medicine preparation in Industry Promotion has very important significance for the treatment of hypertension.

Content of the invention

An object of the present invention be to provide one kind can steadily effectively blood pressure lowering, and can lasting voltage stabilizing drug regimen Thing is used for preventing or treats hypertension, and this pharmaceutical composition contains the crude drug of following weight proportioning：Cortex Eucommiae 3-7 part, Herba Visci 1 Part；Preferably 1 part of Cortex Eucommiae 4-7 part, Herba Visci；More preferably 5 parts of the Cortex Eucommiae, 1 part of Herba Visci.

Wherein, the described Cortex Eucommiae is Cortex Eucommiae health product or processed product, preferably processed product.

Present invention also offers a kind of pharmaceutical preparation, it is pharmaceutically acceptable with one or more by aforementioned pharmaceutical compositions Adjuvant or excipient be prepared from；Wherein, described preparation is preferably pill, capsule, granule, tablet, oral liquid or note Penetrate agent.

A kind of method preparing aforementioned pharmaceutical compositions is additionally provided, it comprises the following steps in the present invention：

（a）Weigh the Cortex Eucommiae, Herba Visci medical material in prescription ratio, be ground into coarse powder；

（b）Plus the water of 8 times of weight（Gross weight with respect to the Cortex Eucommiae and Herba Visci proportioning）, boil and carry 2 times, 1 hour every time, filter Cross, collect filtrate；

（c）Filtrate crosses D101 macroporous resin, first washes with water to substantially colorless, then with 3 times 70% of ethanol elution, collection is washed De- liquid；

（d）Being concentrated into when 60 DEG C and measuring relative density is 1.05, dry pharmaceutical composition.

Invention also provides described pharmaceutical composition is in the medicine of preparation prevention or treatment pneumonia in aged Application.

Present invention also offers described pharmaceutical composition improves the medicine of blood lipid metabolism, insomnia, irritability, irritated symptom in preparation Application in thing.

The present inventor finds in an experiment, in aforementioned pharmaceutical compositions administration process, spontaneous hypertensive rat is had substantially Hypotensive effect, its pressure reduction is gently stable；After drug withdrawal, rat blood pressure still maintains reduced levels, illustrates that pharmaceutical composition has There is good voltage regulation result.T-CHOL（TC）, triglyceride（TG）It is considered as abnormalities of sugar/lipid metabolism etc. the rising of index Evaluation index [Bi Yuanyuan etc., the Recent Advances in Mechanism of Chinese medicine hypertension, modern combination of Chinese and Western medicine magazine, 2008,17 (7):1125-1126.], the present inventor is by free fatty in SHR rat blood serum（FG）, total triglyceride（TG）, total gallbladder Sterin（TC）Deng biochemical indicator detection it was demonstrated that pharmaceutical composition can reduce the content of These parameters composition in rat blood serum, from And improve lipid metabolism.

The explanation of above-mentioned experimental result, this pharmaceutical composition not only can the blood pressure lowering of continued smooth and voltage stabilizing, have simultaneously and change Effect of kind blood lipid metabolism.Because hypertension is the common disease of old people, Patients with Senile Hypertension fluctuation of blood pressure is larger, and It is often accompanied by the syndromes such as hyperlipemia, obesity, treatment pneumonia in aged preferably adopts gentle antihypertensive drugs, should note simultaneously [scape wishes east etc., the treatment of pneumonia in aged and the prevention of cardiovascular and cerebrovascular disease, and Changchun is cured for treatment to its syndrome again Learn, 2008,6 (2):74-76.], therefore this pharmaceutical composition is especially suitable with hyperlipidemia patient to pneumonia in aged.

Additionally, prior art is frequently with sedation [Wang Qiong etc., the conventional calmness Chinese medicine of autonomic activitieses experimental evaluation medicine Compatibility and pharmacological research overview, CHINA JOURNAL OF CHINESE MATERIA MEDICA, 2007,32 (22):2342-2345.], the present inventor is administered by mensure The autonomic activitieses value of mice is it was demonstrated that pharmaceutical composition can reduce mice autonomic activitieses thus playing calm effect afterwards；This medicine is described Compositions, while preventing or treat high blood pressure disease, have good treatment to symptoms such as adjoint insomnia, agitation, irritabilities Effect.Meanwhile, mouse stomach administration carries out acute toxicological experiment and shows that this pharmaceutical composition toxicity is low, and safety is good.

The present invention has advantages below：

1st, pharmaceutical composition provided by the present invention, not only has more preferable hypotensive effect, and can also make blood after being discontinued Pressure is maintained at relatively stable level, has significant voltage regulation result.

2nd, pharmaceutical composition provided by the present invention has and improves blood lipid metabolism and sedation, can alleviate hypertension disease The symptoms such as the adjoint dysbolism of blood fat of disease, agitation, irritability.

3rd, pharmaceutical composition provided by the present invention and medicament composing prescription of the prior art（The crude drug Cortex Eucommiae:Herba Visci=1:1） Compare, effective dose is lower, the medication dose of patient can be reduced.

4th, pharmaceutical composition safety provided by the present invention is good.

5th, pharmaceutical composition provided by the present invention, prescription is simple, not only contributes to the control of production cost, is also beneficial to Control of product quality and inspection, are suitable for industrialized great production.

Specific embodiment

Following examples are that the present invention is explained further, can not be used as the limit further to the scope of the present invention System.

Embodiment 1 pharmaceutical composition preparation research of the present invention

Take the Cortex Eucommiae and the Herba Visci medical material of different proportion compatibilities by table 1, be ground into coarse powder, plus the water of 8 times of weight (is shut out relatively The secondary gross weight with Herba Visci proportioning), boil and carry 2 times, 1 hour every time, filtration, filtrate crosses D101 macroporous resin, first wash with water to Substantially colorless, then with 3 times 70% of ethanol elution, collect eluent, concentrating the relative density being allowed to measure when 60 DEG C is 1.05, dry pharmaceutical composition, measure pharmaceutical composition weight, calculated yield, the results are shown in Table 1：

The preparation research of table 1 different ratio medical material

The research of the different proportion compatibility prescription hypotensive effect of embodiment 2

Take from Essential hypertension（SHR）Rat 80, male, measure initial blood pressure, be randomly divided into 10 groups by blood pressure, i.e. mould Type matched group, Lip river work happiness group, Cortex Eucommiae group, Herba Visci group, pharmaceutical composition 1, pharmaceutical composition 2, pharmaceutical composition 3, medicine group Compound 4, pharmaceutical composition 5, pharmaceutical composition 6（Pharmaceutical composition 1-6 raw materials used medical material ratio is shown in Table 2, and preparation method is with real Apply example 1）.Wherein gavage gives to be equivalent to the dosage of 10g crude drug/kg respectively for Cortex Eucommiae group, Herba Visci group, pharmaceutical composition 1-6 group （Converted into according to yield in embodiment 1）, measure pressure value after being administered 7 days, the results are shown in Table 2：

The research of the different proportion compatibility prescription hypotensive effect of table 2

Note：Compare with model control group,^*P<0.05,^**P<0.01；Compare with Cortex Eucommiae group, #P<0.05

From experimental result it can be seen that：Pharmaceutical composition 1-3（The Cortex Eucommiae:Herba Visci=7:1～3:1）Antihypertensive effect be better than Pharmaceutical composition 4（The Cortex Eucommiae:Herba Visci=1:1）, and it is significantly better than Cortex Eucommiae group and Herba Visci group；Meanwhile, pharmaceutical composition 1-3 Dosage is significantly lower than pharmaceutical composition 4, illustrates that the effective dose of pharmaceutical composition 1-3 is lower；Outstanding in each pharmaceutical composition The most obvious with the antihypertensive effect of pharmaceutical composition 2, i.e. the Cortex Eucommiae:Herba Visci=4.88:When 1, antihypertensive effect is the most notable.

Different Cortex Eucommiae crude drug in embodiment 3 pharmaceutical composition（Health product or processed product）Research

Have when Traditional Chinese medicine eucommia bark is medicinal processed product and health product point, and salt Cortex Eucommiae (processed) is a kind of more main flow in processed product Processed product.Existing 2010 versions《Chinese Pharmacopoeia》In included salt Cortex Eucommiae (processed), its processing procedure is：Take Cortex Eucommiae block or silk, plus Vinegar is mixed thoroughly, vexed, puts in parch container, fries to fracture of wire, surface coke black, takes out, dry in the air cool.

From the processing Cortex Eucommiae with reference to above-mentioned 2010 versions in this experiment《Chinese Pharmacopoeia》The processing procedure preparation of middle salt Cortex Eucommiae (processed).

In this experiment, the commercially available processing Cortex Eucommiae is purchased from Sichuan Naruhito hall prepared slices of Chinese crude drugs company, and the health product Cortex Eucommiae is purchased from five blocks of Chengdu stone Medicinal material market.

Pharmaceutical composition is prepared according to embodiment 1（Wherein, the weight of the Cortex Eucommiae and Herba Visci is than for 5:1）, it is respectively adopted life Product and the different processed product Cortex Eucommiae prepare pharmaceutical composition with Herba Visci, measure gained pharmaceutical composition weight, calculated yield, result It is shown in Table 3：

The different Cortexs Eucommiae in table 3（Health product or processed product）Crude drug prepares the research of pharmaceutical composition

Take spontaneous hypertensive rat 40, male, measure initial blood pressure, be randomly divided into 5 groups by blood pressure, i.e. model comparison Group, Lip river work happiness group, pharmaceutical composition difference processed product group (from processing group, Cortex Eucommiae health product group, commercially available processing group), each group gavage is given Medicine, gives to be equivalent to the dosage of 10g crude drug/kg respectively（Converted into according to yield in table 3 and calculate）, distinguish successive administration and survey after 7 days Determine pressure value, the results are shown in Table 4.

The different Cortexs Eucommiae in table 4 compositionss（Health product or processed product）Research

Note：Compare with model control group,^**P<0.01

Table 4 result shows：SHR rat blood pressure all can be significantly reduced with the pharmaceutical composition that health product and processed product are made, say The bright pharmaceutical composition containing the health product Cortex Eucommiae or the processed product Cortex Eucommiae all can produce good antihypertensive effect, and the two is all applied to preparation Aforementioned pharmaceutical compositions, and the processed product Cortex Eucommiae should be preferred.

Embodiment 4 pharmaceutical composition blood pressure lowering, voltage stabilizing and the research improving blood lipid metabolism

Take spontaneous hypertensive rat 48, male, measure initial blood pressure, be randomly divided into 6 groups by blood pressure, i.e. model comparison Group, Lip river work happiness group, Duzhong Jiangya Tablets（Hall is laughed in Hunan one）, pharmaceutical composition（The crude drug Cortex Eucommiae:Herba Visci=5:1, preparation method is same Embodiment 1）High, medium and low dosage group.By table 5, gavage gives corresponding dosage, successive administration 30 days respectively, 1 day 1 time, distinguishes Measure each Mus pressure value after being administered 10,20,30,40 days, measure free fatty in serum in administration blood sampling in 30 days（FG）, total Triglyceride（TG）, T-CHOL（TC）, feritin（Renin）Level, result is as shown in table 5, table 6.

The impact to SHR rat blood pressure level for table 5 pharmaceutical composition

Note：Compare with model control group, * P<0.05 **P<0.01

Table 5 result shows：After being administered 10 days, each dosage group of pharmaceutical composition all has hypotensive effect, especially high, middle dose group Effect is the most obvious（P<0.05）；With the increase of administration natural law, each dosage group of pharmaceutical composition all can substantially reduce rat serum Pressure, suppression rat blood pressure raises, and its antihypertensive effect is better than Chinese medicine positive controls（Duzhong Jiangya Tablets）, wherein high, middle dose group Effect is the most obvious, and has significant difference compared with model control group（P<0.05）.

Start to be discontinued 10 days within 30th day, serious rebound phenomena in Lip river happiness group alive, and blood pressure recovers to model after administration Matched group level, and Chinese medicine each group all embodies continual and steady hypotensive effect, especially pharmaceutical composition height, middle dose group and Du Secondary hypertension pill is the most notable（P<0.05 or P<0.01）.The above results illustrate that pharmaceutical composition of the present invention not only has during being administered There is obvious hypotensive effect, and after drug withdrawal, still there is obvious pressure stabilization function.

The impact to SHR rat related biochemical indicator for table 6 pharmaceutical composition

Note：Compare with model control group, * P<0.05 **P<0.01

Table 6 result shows：After administration 30 days, pharmaceutical composition all has different degrees of fall to FG, TG, TC, Renin level Low effect, and there is significant difference（P<0.05 or P<0.01）.Testing result explanation pharmaceutical composition can while blood pressure lowering Significantly improve blood lipid metabolism.

The impact to mice autonomic activitieses for embodiment 5 pharmaceutical composition

Take healthy Kunming mouse, measure its autonomic activitieses value, therefrom filter out 36 mices, male and female half and half, by its body Weight and autonomic activitieses value are randomly divided into 3 groups, i.e. model control group, stable group（Positive controls）, pharmaceutical composition group（With enforcement Example 4）, by table 7 dosage gastric infusion, successive administration 1 week, measure its autonomic activitieses value within 1 hour after last dose, the results are shown in Table 7.

The impact to mice autonomic activitieses for table 7 pharmaceutical composition

Note：Compare with model control group,^*P<0.05

Table 7 result shows：Pharmaceutical composition plays the role of certain suppression mice autonomic activitieses, and this pharmaceutical composition is described There is sedation, the symptoms such as patient's irritability, agitation, insomnia can be improved.

Embodiment 6 pharmaceutical composition acute toxicity test is studied

Give the pharmaceutical composition of mice maximum volume or dosage through prerun gavage（With embodiment 4）Afterwards, fail to measure half Number lethal dose LD50, in being by mtd test.

Mtd test：This pharmaceutical composition is formulated as Cmax 0.468g/mL, by maximum volume 0.4ml/ 10g body weight gastric infusion is twice（Dosing interval 4 hours twice）, reduce except spontaneous activity in minority animal after administration, roll up Motionless outer, have no other untoward reaction.After observing 14 days, have no animal dead, internal important organ（The heart, liver, spleen, lung, kidney）, It is showed no exception.The maximum tolerated dose calculating pharmaceutical composition is 37.44g/kg.

According to have in embodiment 4 significant difference rat minimum effective dose be 160mg/kg, change by Shape Coefficient Algorithm calculates human clinical's dosage, and computing formula is as follows：

$\mathrm{dB}=\mathrm{dA}\&times;\frac{R_B}{R_A}\&times;\sqrt[2]{\frac{W_A}{W_B}}=160\mathrm{mg}/\mathrm{kg}\&times;\frac{0.11}{0.09}\&times;\sqrt[2]{\frac{0.2}{70}}=27.75\mathrm{mg}/\mathrm{kg}$

Wherein, dB represents animal B to be asked（Representative herein）Kg body weight dosage, dA represent known to animal A（It is herein Rat）Kg body weight dosage, W_A、W_BRepresent the body weight of animal A, B respectively（General rat body weight 0.2kg, body weight of being grown up 70kg）, R_A、R_BRepresent the Shape Coefficient of animal A, B respectively（Rat Shape Coefficient is 0.09, and the Shape Coefficient of people is 0.11）[old Very, herbal pharmacology experimental technique, People's Health Publisher, 1994:206.]；Result of calculation shows, human clinical's dosage is 27.75mg/kg.

This experimentation understands that the mice maximum tolerated dose of this pharmaceutical composition is the 1349 of its human clinical's dosage Times, show that pharmaceutical composition has good drug safety.

The preparation of embodiment 7 pharmaceutical composition

Take the Cortex Eucommiae (salt is processed) 1389g, Herba Visci 278g, be ground into coarse powder, plus the water of 8 times of weight（With respect to the Cortex Eucommiae and Mongolian oak The gross weight of parasitic proportioning）, boil and carry 2 times, 1 hour every time, filter, filtrate is crossed D101 macroporous resin, first washed with water to substantially no Color, then with 3 times 70% of ethanol elution, collect eluent, being concentrated into when 60 DEG C and measuring relative density is 1.05, dry medicine Compositionss extract 40.3g.

The preparation of embodiment 8 pharmaceutical composition

Preparation method with embodiment 7, wherein raw material survival dose is：The Cortex Eucommiae (salt is processed) 1459g, Herba Visci 208g, obtain medicine Compositionss extract 37.2g.

The preparation of embodiment 9 pharmaceutical composition

Preparation method with embodiment 7, wherein raw material survival dose is：The Cortex Eucommiae (salt is processed) 1250g, Herba Visci 417g, obtain medicine Compositionss extract 48.5g.

The preparation of embodiment 10 capsule

The pharmaceutical composition 40.3g of Example 7, after crossing 40 mesh sieves, adds Pregelatinized Starch to make its weight reach 340g, Add Pulvis Talci 18g, magnesium stearate 2g mix homogeneously, load capsule, make 1000.

The preparation of embodiment 11 tablet

The pharmaceutical composition 40.3g of Example 7, after crossing 40 mesh sieves, adds Lactose to make its weight reach 408g, adds Starch 50g, Hydroxypropyl Cellulose 40g, mix homogeneously, use 75% alcohol granulation, be dried, granulate, add the mixing of 2g magnesium stearate all Even, tabletting, make 1000.

The preparation of embodiment 12 granule

The pharmaceutical composition 40.3g of Example 7, after crossing 40 mesh sieves, adds Lactose to make its weight reach 630g, Mannitol 70g mix homogeneously, uses 75% alcohol granulation, is dried, granulate, makes 450 bags.

Claims (8)

1. the pharmaceutical composition of a kind of prevention or treatment hypertension is it is characterised in that this pharmaceutical composition is by following weight proportioning Crude drug forms：1 part of Cortex Eucommiae 4-7 part, Herba Visci.

2. according to claim 1 prevention or treatment hypertension pharmaceutical composition it is characterised in that：It is characterized in that should Pharmaceutical composition is made up of the crude drug of following weight proportioning：5 parts of the Cortex Eucommiae, 1 part of Herba Visci.

3. the prevention according to any one of claim 1-2 or treatment hypertension pharmaceutical composition it is characterised in that：Institute Stating the Cortex Eucommiae is processed product.

4. the pharmaceutical preparation that the pharmaceutical composition described in claim 1-3 is made, its comprise one or more pharmaceutically acceptable Adjuvant or excipient.

5. pharmaceutical preparation according to claim 4 it is characterised in that：Described pharmaceutical preparation is pill, capsule, granule Agent, tablet, oral liquid or injection.

6. the preparation method of the pharmaceutical composition described in claim 1-3, it comprises the following steps：

A () weighs the Cortex Eucommiae, Herba Visci medical material by prescription proportioning, be ground into coarse powder；

B () plus the water with respect to the Cortex Eucommiae and 8 times of the gross weight of Herba Visci proportioning, boils and carries 2 times, 1 hour every time, filter, collect filter Liquid；

C () filtrate crosses D101 macroporous resin, first wash with water to substantially colorless, then with 3 times 70% of ethanol elution, collects eluting Liquid；

D () concentrates and be allowed to the relative density that measures when 60 DEG C is 1.05, dry pharmaceutical composition.

7. the pharmaceutical composition of the prevention according to any one of claim 1-2 or treatment hypertension is it is characterised in that institute Stating hypertension is pneumonia in aged.

8. the pharmaceutical composition described in claim 1-3 improves the medicine of blood lipid metabolism, insomnia, irritability, irritated symptom in preparation In application.