CN101810656A - Siberian ginseng extract and medicine combination thereof - Google Patents
Siberian ginseng extract and medicine combination thereof Download PDFInfo
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- CN101810656A CN101810656A CN 201010165556 CN201010165556A CN101810656A CN 101810656 A CN101810656 A CN 101810656A CN 201010165556 CN201010165556 CN 201010165556 CN 201010165556 A CN201010165556 A CN 201010165556A CN 101810656 A CN101810656 A CN 101810656A
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Abstract
The invention provides a siberian ginseng extract and a medicine combination thereof. Siberian ginseng is extracted by water and precipitated by alcohol, lime milk regulates the pH value to 10.0 to 12.0, the siberian ginseng is kept still for over 4 hours, sulfuric acid regulates the pH value to 5.0 to 6.0, and the siberian ginseng is precipitated by alcohol again, so that the siberian ginseng extract is produced. The siberian ginseng extract does not contain chlorogenic acid, and effectively maintains active components, while impurities are effectively reduced. Experiments show that the siberian ginseng extract only causes little anaphylactic reaction and has the effect of treating senile dementia.
Description
Technical field
The present invention relates to a kind of raw material of Chinese medicine extract, specifically a kind of Radix Et Caulis Acanthopanacis Senticosi extract the invention still further relates to and contains this extract pharmaceutical composition.
Background technology
Radix Et Caulis Acanthopanacis Senticosi injection is the Chinese medicine injection of being made by the effective ingredient that proposes in the Araliaceae Radix Et Caulis Acanthopanacis Senticosi, wherein contains effective ingredient such as multiple Radix Et Caulis Acanthopanacis Senticosi glucoside, different fraxin, ligustrin, hyperin, Radix Et Caulis Acanthopanacis Senticosi polysaccharide.Radix Et Caulis Acanthopanacis Senticosi can be regulated the metabolic function of body, improve the nonspecific resistance of body to the destructive stimulus factor, can strengthen the function of hypophysis-interrenal system, improve the adaptability and the toleration of body, lower of the infringement of the multiple virulence factor in inside and outside, promptly have excitation that inhibitory action is arranged again the central nervous system to body.The expansible blood vessel of Radix Et Caulis Acanthopanacis Senticosi injection, coronary blood flow increasing, minimizing oxygen consumption, blood viscosity lowering, improve blood circulation, and calmness is arranged, improve effects such as sleep, stimulating appetite.Be mainly used in transient ischemic attack due to the deficiency of the liver and kindey, cerebral arteriosclerosis, cerebral thrombosis, cerebral embolism etc.
In recent years because it has report when using caused untoward reaction clinically widely.Its untoward reaction type mainly contains anaphylaxis, anaphylactic shock, systemic anaphylaxis etc., clinical dizziness, headache, uncomfortable in chest, dyspnea, blood pressure drops, the agitation of mainly showing as, part patient is with erythra, whole body pruritus, heating, shiver with cold, nasal obstruction, watery nasal discharge etc.
Cause the reason of above-mentioned untoward reaction to mainly contain: the Radix Et Caulis Acanthopanacis Senticosi goods mainly adopt solvent extraction method slightly to carry at present, adopt of solvent contained alcoholic acid aqueous solution more, and then make with extra care according to different needs, this method causes that the impurity that contains in the Radix Et Caulis Acanthopanacis Senticosi goods is many, effective ingredient is few, and contains sensitizer.Up to the present, the report that does not also address the above problem.
Summary of the invention
First purpose of the present invention is to provide a kind of Radix Et Caulis Acanthopanacis Senticosi extract at above-mentioned deficiency, and it has safety preferably.
Second purpose of the present invention is to provide the method for the above-mentioned Radix Et Caulis Acanthopanacis Senticosi extract of preparation.
The 3rd purpose of the present invention is to provide the application of above-mentioned Radix Et Caulis Acanthopanacis Senticosi extract in field of medicaments.
Radix Et Caulis Acanthopanacis Senticosi extract of the present invention is that Radix Et Caulis Acanthopanacis Senticosi is transferred pH to 10.0-12.0 through water extract-alcohol precipitation, lime cream, leaves standstill more than 4 hours, sulphuric acid transfers pH to 5.0-6.0, obtains behind the precipitate with ethanol once more.Do not contain chlorogenic acid in this Radix Et Caulis Acanthopanacis Senticosi extract, and well kept the effective ingredient impurity component and then effectively reduced.
Particularly, Radix Et Caulis Acanthopanacis Senticosi extract of the present invention can prepare by the following method: Radix Et Caulis Acanthopanacis Senticosi is cut into pieces, decoct with water, collecting decoction, concentrating under reduced pressure, adding ethanol to pure content is 70～75%, leave standstill filtration, thin up, leaves standstill more than 4 hours with lime cream adjust pH to 10.0～12.0 to 3-6 times of crude drug weight behind the recovery ethanol, reuse sulphuric acid transfers to 5.0-6.0 with pH value, leave standstill filtration, concentrate, adding ethanol to pure content is 80～85%, leave standstill filtration, centrifugalize impurity, concentrate drying behind the medicinal liquid recovery ethanol, promptly.
In the above-mentioned steps, decoct with water usually when water is carried 2～3 times, the decocting that at every turn adds 4～10 times of amounts (weight) boiled 30～60 minutes; Detecting relative density when concentrating under reduced pressure is concentrated into 80 ℃ usually is 1.11～11.4; Leave standstill filter process and left standstill usually 12～24 hours, impurity can effectively be precipitated; Centrifugal usually with 1500-3000rpm, centrifugal 20-40min removes precipitation.
Adopt water extract-alcohol precipitation, fresh lime cream to transfer pH to 10.0-12.0, sulphuric acid to transfer pH to 5.0-6.0, step such as precipitate with ethanol once more in this method, well keep effective ingredient, removed non-active ingredient such as chlorogenic acid simultaneously, reduced the introducing amount of impurity, reduce toxicity, guaranteed the safety of medicine.
Radix Et Caulis Acanthopanacis Senticosi total glucosides accounts for 2%-20% in the Radix Et Caulis Acanthopanacis Senticosi extract that the said method extraction obtains, and total flavones accounts for 3.5%-35%, and total amino acids and total sugar account for 30%-40%, and all the other are organic acid, macroelement and trace element etc., and do not contain chlorogenic acid.Usually Radix Et Caulis Acanthopanacis Senticosi total glucosides accounts for 5%-10%, and the manyprickle acanthopanax general flavone accounts for 8.5%-10.5%, and total amino acids and total sugar account for 35%-40%, and surplus is organic acid, macroelement and trace element etc., and does not contain chlorogenic acid.Wherein, syringoside accounts for the 10%-20% of Radix Et Caulis Acanthopanacis Senticosi total glucosides in the extract.
Experiment shows that Radix Et Caulis Acanthopanacis Senticosi extract anaphylaxis of the present invention is little, has the effect of treatment senile dementia.
Radix Et Caulis Acanthopanacis Senticosi extract of the present invention can become various pharmaceutical compositions with pharmaceutically acceptable preparing carriers, includes but not limited to injection, lyophilized injectable powder, tablet, capsule, granule, dispersible tablet, drop pill, effervescent tablet, soft capsule, oral liquid.Wherein be preferably injection.
In addition, Radix Et Caulis Acanthopanacis Senticosi extract of the present invention can also be united use with other medicines, for example directly replaces the Radix Et Caulis Acanthopanacis Senticosi extract in the existing pharmaceutical composition, is used for the treatment of various diseases.
The present invention has the following advantages:
1) do not contain chlorogenic acid in the extract, impurity content is few, has reduced the generation of untoward reaction, uses safer.
2) preparation method: in the process with the lime sulphur treatment medicinal liquid, transfer pH to 10.0-12.0 and leave standstill more than 4 hours with lime cream, solution is strong basicity, and with this understanding, chlorogenic acid is fallen by complete hydrolysis; After stone sulfur method, increase step precipitate with ethanol reaction again, significantly reduced foreign aid's property impurity that sulphuric acid, lime cream etc. bring; Simultaneously, lime cream and vitriolic consumption also are reduced to 1/4th to 1/5th of present usual amounts, have reduced bringing into of impurity, especially the introducing of calcium ion.
The specific embodiment
Following examples further specify content of the present invention, but should not be construed as limitation of the present invention.Without departing from the spirit and substance of the case in the present invention, modification or replacement to the inventive method, step or condition are done all belong to scope of the present invention.
If do not specialize the conventional means that used technological means is well known to those skilled in the art among the embodiment.
The extract of embodiment 1 existing prepared
The Radix Et Caulis Acanthopanacis Senticosi bar is cut into pieces, add 10 times of amount 60% ethanol extractions 2 times, each 1 hour, merging filtrate, concentrating under reduced pressure, last D201 type resin is used 70% ethanol elution, collects eluent, concentrate drying, promptly.
After testing, contain chlorogenic acid 1.24% in the extract, impurity accounts for 4.2%.
The extract of embodiment 2 the inventive method preparation
The Radix Et Caulis Acanthopanacis Senticosi bar is cut into pieces, decoct with water 3 times, add 5 times of water gagings for the first time, decocted 30 minutes; For the second time add 6 times of water gagings, decocted 40 minutes; Add 4 times of water gagings for the third time, decocted 30 minutes.Collecting decoction, detecting relative density when being evaporated to 80 ℃ is 1.11, adds ethanol and makes and contain the alcohol amount and reach 75%, leaves standstill filtration, reclaims behind the ethanol thin up to 4 times of crude drug weight.It with percentage by weight 20% lime cream adjust pH to 11.0, the reuse percentage by weight is that 20% sulphuric acid transfers to 5.1 with pH value, leave standstill filtration, detecting relative density when being concentrated into 80 ℃ is 1.13, add ethanol once more and make and contain alcohol amount and reach 84%, leave standstill filtration, centrifugalize impurity, concentrate drying behind the medicinal liquid recovery ethanol, promptly.
After testing, do not detect chlorogenic acid in the extract, impurity accounts for 1.5%.
The extract of embodiment 3 the inventive method preparation
The Radix Et Caulis Acanthopanacis Senticosi bar is cut into pieces, decoct with water 2 times, add 8 times of water gagings for the first time, decocted 60 minutes; For the second time add 6 times of water gagings, decocted 40 minutes; Add 6 times of water gagings for the third time, decocted 30 minutes.Collecting decoction, detecting relative density when being evaporated to 80 ℃ is 1.14, adds ethanol and makes and contain the alcohol amount and reach 70%, leaves standstill filtration, reclaims behind the ethanol thin up to 5 times of crude drug weight.It with percentage by weight 20% lime cream adjust pH to 11.5, the reuse percentage by weight is that 20% sulphuric acid transfers to 5.4 with pH value, leave standstill filtration, detecting relative density when being concentrated into 80 ℃ is 1.12, add ethanol once more and make and contain alcohol amount and reach 80%, leave standstill filtration, centrifugalize impurity, concentrate drying behind the medicinal liquid recovery ethanol, promptly.
After testing, do not detect chlorogenic acid in the extract, impurity accounts for 1.7%.
The extract of embodiment 4 the inventive method preparation
The Radix Et Caulis Acanthopanacis Senticosi bar is cut into pieces, decoct with water 3 times, add 8 times of water gagings for the first time, decocted 60 minutes; For the second time add 4 times of water gagings, decocted 40 minutes; Collecting decoction, detecting relative density when being evaporated to 80 ℃ is 1.13, adds ethanol and makes and contain the alcohol amount and reach 73%, leaves standstill filtration, reclaims behind the ethanol thin up to 3 times of crude drug weight.It with percentage by weight 20% lime cream adjust pH to 12.0, the reuse percentage by weight is that 20% sulphuric acid transfers to 6.0 with pH value, leave standstill filtration, detecting relative density when being concentrated into 80 ℃ is 1.11, add ethanol once more and make and contain alcohol amount and reach 83%, leave standstill filtration, centrifugalize impurity, concentrate drying behind the medicinal liquid recovery ethanol, promptly.
After testing, do not detect chlorogenic acid in the extract, impurity accounts for 2.1%.
Embodiment 5 injection
Get embodiment 2 extract obtained 100g, add the water for injection dilution, 100-120 ℃ of heat treatment filters, and 0-4 ℃ of cold preservation is handled, filter, and adjust pH to 5.5, charcoal treatment is filtered, sterilization, cold preservation is handled, ultrafiltration, fill, every 20ml, sterilization, promptly.
After testing, total glycosides content is 2.8mg/ml, and wherein syringoside is 0.41mg/ml, and general flavone content is 5.3mg/ml, and total sugar and total amino acids are 19.7mg/ml, do not detect chlorogenic acid.
Embodiment 6 injection
Get embodiment 3 extract obtained 300g, add the water for injection dilution, 100-120 ℃ of heat treatment filters, and 0-4 ℃ of cold preservation is handled, filter, and adjust pH to 5.5, charcoal treatment is filtered, sterilization, cold preservation is handled, ultrafiltration, fill, every 100ml, sterilization, promptly.
After testing, total glycosides content is 1.68mg/ml, and wherein syringoside is 0.26mg/ml, and general flavone content is 2.97mg/ml, and total sugar and total amino acids content are 18.16mg/ml, do not detect chlorogenic acid.
Embodiment 7 injection
Get embodiment 3 extract obtained 400g, add the water for injection dilution, 100-120 ℃ of heat treatment filters, and 0-4 ℃ of cold preservation is handled, filter, and adjust pH to 5.5, charcoal treatment is filtered, sterilization, cold preservation is handled, ultrafiltration, fill, every 250ml, sterilization, promptly.
After testing, total glycosides content is 1.16mg/ml, and wherein syringoside is 1.14mg/ml, and general flavone content is 1.89mg/ml, and total sugar and total amino acids content are 20.05mg/ml, do not detect chlorogenic acid.
Embodiment 8
It is extract obtained to get embodiment 4, adds the cane sugar powder mix homogeneously, and granulation, drying, granulate mixing, pack, packing get granule.
Embodiment 9
It is extract obtained to get embodiment 5, adds the dextrin mix homogeneously, and granulation, cold drying, granulate mixing, tabletting, coating get tablet.
Embodiment 10
It is extract obtained to get embodiment 2, adds the starch mix homogeneously, and cold drying is ground into fine powder, incapsulates, and gets capsule.
Embodiment 11
It is extract obtained to get embodiment 2, is dissolved in water, and adds correctives, stirs evenly filtration, mends and adds water to ormal weight, gets oral liquid.
Embodiment 12
It is extract obtained to get embodiment 2, adds the water for injection dilution, filtration, and adjust pH to 5.5, charcoal treatment is filtered, sterilization, cold preservation is handled, filters, ultrafiltration, fill, lyophilization gets lyophilized injectable powder.
The 1 hypersensitive test comparative study of test example
Sample: embodiment 5 samples, commercially available Radix Et Caulis Acanthopanacis Senticosi injection
Method: get 24 of body weight 250-300g Cavia porcelluss, be divided into four groups at random, 6 every group.Negative control group: lumbar injection 0.9% sodium chloride injection; Positive controls: lumbar injection 5% fresh albumen solution.Test 1 group: lumbar injection embodiment 5 samples; Test 2 groups: the commercially available Radix Et Caulis Acanthopanacis Senticosi injection of lumbar injection.Dosage only is 0.5ml/.The next day once, totally three times.After the first administration 14 days, 21 days, get 2 at random for every group, test 1 group and 2 groups respectively by auricular vein injection embodiment 5 samples and commercially available Radix Et Caulis Acanthopanacis Senticosi injection; Negative control group is injected 0.9% sodium chloride injection, and positive controls is injected 5% fresh albumen solution.Dosage only is 1.0ml/.Observe immediately after the administration that animal has or not sneeze, scratches nose, dry cough or cough, tremble, the anaphylaxis of perpendicular hair, tic, dyspnea, gatism, shock and death, be 15 minutes observing time.The anaphylaxis classification sees Table 1.
Table 1 anaphylaxis classification and decision method as a result
The result: the Cavia porcellus anaphylaxis progression of injecting the negative control group of 0.9% sodium chloride injection is 0, does not have irritated reaction; The positive controls Cavia porcellus of injecting 5% Ovum Gallus domesticus album sneeze occurs, scratches nose, retch or cough, twitch, tremble, anaphylaxiss such as dyspnea, gatism, shock, and all dead in 15min, anaphylaxis progression is 4 grades, experimental condition is set up.6 Cavia porcelluss that the test of injection embodiment 5 samples is 1 group all do not have irritated reaction, and anaphylaxis progression is 0.Injecting in 6 Cavia porcelluss of 2 groups of tests of commercially available Radix Et Caulis Acanthopanacis Senticosi injection has 1 Cavia porcellus nose, a perpendicular hair phenomenon to occur slightly grabbing, and anaphylaxis progression is 1.Show the safe of embodiment 5 samples in commercially available Radix Et Caulis Acanthopanacis Senticosi injection.Experimentize with the injection of embodiment 6 and 7 and also to have obtained similar result.
2 pairs of senile dementia learning and memory function influences of test example test
Sample: embodiment 2 samples, piracetam medicinal liquid
Modeling: after the animal adaptability fed for 1 week, remove the too fast or slow person of mistake of reaction through determined with Morris water, all the other rats are divided into blank group (10) and modeling group (50) at random.Modeling group rat carries on the back the cervical region injection of d-galactose every day, blank group back of the body cervical region subcutaneous injection 0.9% sodium chloride solution, and dosage is 0.1ml/100g, continuous 30 days.Carry out the water maze training after the modeling, meansigma methods with blank group rat escape latency after the modeling is a reference value, 30 days every rat average escape latency values after the calculating modeling, difference as rat average escape latency value and reference value accounts for more than 20% of this rat average escape latency value, is the modeling success.
Grouping administration: select 40 of modeling success rats, be divided into Model of Dementia group, low dose group, high dose group and positive controls at random, 10 every group.Blank group and Model of Dementia group are irritated stomach and are given 0.9% sodium chloride solution, and dosage is 1ml/100g; Low dose group is irritated stomach and is given embodiment 2 samples, and dosage is 0.42g/100g; High dose group is irritated stomach and is given embodiment 2 samples, and dosage is 0.84g/100g; Positive controls is irritated stomach and is given piracetam medicinal liquid 0.1g/100g.Every day is inferior, continuous 30 days.
Learning and memory function detects: adopt the water maze system, and carry out automatic trace analysis with the image automated collection systems, write down various parameters.Water temperature is controlled at about 24 ℃, and it is constant that testing crew and surrounding keep.Test before modeling, after the modeling, respectively carry out once after the administration.
Result: begin to finding the time that is hidden in the underwater platform from the rat entry and be escape latency, represent the rat learning capacity with the length of escape latency time.Before the modeling, each escape latency of organizing rat is close; After the modeling, modeling group rat escape latency is obviously than blank group leader; After the administration, low dosage and high dose administration group and positive controls rat escape latency obviously shorten, and low dosage and high dose administration group are close with positive controls rat escape latency.The result shows that embodiment 2 samples have the effect that improves the senile dementia learning and memory function.The result sees table 2 for details.
The influence of table 2 pair senile dementia learning and memory function
Extract with embodiment 3 and 4 carries out above-mentioned experiment, has also obtained similar result.
Claims (10)
1. Radix Et Caulis Acanthopanacis Senticosi extract, it prepares by the following method: Radix Et Caulis Acanthopanacis Senticosi is transferred pH to 10.0-12.0 through water extract-alcohol precipitation, lime cream, leaves standstill more than 4 hours, sulphuric acid is transferred pH to 5.0-6.0, precipitate with ethanol once more.
2. Radix Et Caulis Acanthopanacis Senticosi extract as claimed in claim 1, it is characterized in that, it prepares by the following method: Radix Et Caulis Acanthopanacis Senticosi is cut into pieces, decoct with water, collecting decoction, concentrating under reduced pressure, adding ethanol to pure content is 70～75%, leaves standstill filtration, and thin up is to 3-6 times of crude drug weight behind the recovery ethanol, with lime cream adjust pH to 10.0～12.0, leave standstill more than 4 hours, reuse sulphuric acid transfers to 5.0-6.0 with pH value, leaves standstill filtration, concentrate, adding ethanol to pure content is 80～85%, leaves standstill filtration, centrifugal, concentrate drying, promptly.
3. Radix Et Caulis Acanthopanacis Senticosi extract as claimed in claim 1 or 2 is characterized in that this extract does not contain chlorogenic acid.
4. Radix Et Caulis Acanthopanacis Senticosi extract as claimed in claim 3 is characterized in that Radix Et Caulis Acanthopanacis Senticosi total glucosides accounts for 2%-20% in this extract, and total flavones accounts for 3.5%-35%, and total amino acids and total sugar account for 30%-40%.
5. Radix Et Caulis Acanthopanacis Senticosi extract as claimed in claim 4 is characterized in that syringoside accounts for the 10%-20% of Radix Et Caulis Acanthopanacis Senticosi total glucosides in the extract.
6. method for preparing the described Radix Et Caulis Acanthopanacis Senticosi extract of claim 1, it comprises the steps: that Radix Et Caulis Acanthopanacis Senticosi transfers pH to 10.0-12.0 through water extract-alcohol precipitation, fresh lime cream, leaves standstill more than 4 hours, sulphuric acid is transferred pH to 5.0-6.0, precipitate with ethanol once more.
7. the method for claim 1, it is characterized in that, this method comprises the steps: Radix Et Caulis Acanthopanacis Senticosi is cut into pieces, and decocts with water collecting decoction, concentrating under reduced pressure, adding ethanol to pure content is 70～75%, leaves standstill filtration, and thin up is to 3-6 times of crude drug weight behind the recovery ethanol, with lime cream adjust pH to 10.0～12.0, leave standstill more than 4 hours, reuse sulphuric acid transfers to 5.0-6.0 with pH value, leaves standstill filtration, concentrate, adding ethanol to pure content is 80～85%, leaves standstill filtration, centrifugalize impurity, concentrate drying behind the medicinal liquid recovery ethanol, promptly.
8. the application of each described Radix Et Caulis Acanthopanacis Senticosi extract of claim 1～5 in the preparation medicine for senile dementia.
9. pharmaceutical composition for the treatment of senile dementia, its with each described Radix Et Caulis Acanthopanacis Senticosi extract of claim 1～5 as effective ingredient.
10. pharmaceutical composition as claimed in claim 9, it is injection, lyophilized injectable powder, tablet, capsule, granule, dispersible tablet, drop pill, effervescent tablet, soft capsule or oral liquid that effective ingredient becomes with pharmaceutically acceptable preparing carriers.
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| CN102579532A (en) * | 2011-10-17 | 2012-07-18 | 哈尔滨珍宝制药有限公司 | Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation |
| CN104274533A (en) * | 2014-11-05 | 2015-01-14 | 周玉萍 | Pharmaceutical composition for reducing blood fat |
| CN104306417A (en) * | 2014-09-28 | 2015-01-28 | 哈尔滨珍宝制药有限公司 | Low-toxicity acanthopanax injection and preparation method thereof |
| CN104983869A (en) * | 2015-06-26 | 2015-10-21 | 四川医科大学 | Medicine composition for treating Alzheimer's disease and preparing method and application of medicine composition |
| CN105726947A (en) * | 2016-02-02 | 2016-07-06 | 王知斌 | Acanthopanax senticosus leaf and polygonatum odoratum leaf extract for improving sleeping and reducing blood sugar and preparing method and application thereof |
| CN106474170A (en) * | 2016-11-30 | 2017-03-08 | 哈尔滨珍宝制药有限公司 | A kind of acanthopanax combination, preparation and its detection method |
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| CN102579532A (en) * | 2011-10-17 | 2012-07-18 | 哈尔滨珍宝制药有限公司 | Radix acanthopanacis senticosl composition, preparation containing composition and detection method of preparation |
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| CN104306417A (en) * | 2014-09-28 | 2015-01-28 | 哈尔滨珍宝制药有限公司 | Low-toxicity acanthopanax injection and preparation method thereof |
| CN104306417B (en) * | 2014-09-28 | 2017-09-19 | 哈尔滨珍宝制药有限公司 | A kind of Radix Et Caulis Acanthopanacis Senticosi injection of low toxicity and preparation method thereof |
| CN104274533A (en) * | 2014-11-05 | 2015-01-14 | 周玉萍 | Pharmaceutical composition for reducing blood fat |
| CN104983869A (en) * | 2015-06-26 | 2015-10-21 | 四川医科大学 | Medicine composition for treating Alzheimer's disease and preparing method and application of medicine composition |
| CN104983869B (en) * | 2015-06-26 | 2018-01-05 | 四川医科大学 | Treat pharmaceutical composition of senile dementia and its preparation method and application |
| CN105726947A (en) * | 2016-02-02 | 2016-07-06 | 王知斌 | Acanthopanax senticosus leaf and polygonatum odoratum leaf extract for improving sleeping and reducing blood sugar and preparing method and application thereof |
| CN105726947B (en) * | 2016-02-02 | 2019-08-16 | 黑龙江中医药大学 | A kind of improvement sleep, hypoglycemic acanthopanax radix polygonati officinalis leaf extract and its preparation method and application |
| CN106474170A (en) * | 2016-11-30 | 2017-03-08 | 哈尔滨珍宝制药有限公司 | A kind of acanthopanax combination, preparation and its detection method |
| CN106474170B (en) * | 2016-11-30 | 2019-06-14 | 哈尔滨珍宝制药有限公司 | A kind of acanthopanax combination, preparation and its detection method |
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