CN101780218B - Medicinal lotion for treating haemorrhoids - Google Patents
Medicinal lotion for treating haemorrhoids Download PDFInfo
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Abstract
The invention relates to a medicament for treating haemorrhoids on the basis of natural plants. The medicinal lotion of the invention for treating haemorrhoids is particularly a medicament for external administration, which is prepared from the following components by weight ratio: 80 parts of pseudo-ginseng, 80 parts of purslane, 110 parts of kuh-seng, 100 parts of rhizoma bletillae, 100 parts of common cnidium fruit, 100 parts of field pennycress, 65 parts of folium artemisiae argyi, 100 parts of pagoda tree fruit, 65 parts of honeysuckle, 65 parts of radix sileris, 50 parts of alum, 50 parts of borax, 5 parts of borneol, 30 parts of liquorice, 1 to 40 parts of carboxymethyl cellulose (CMC) and 80 parts of polysorbate. The medicament of the invention is mainly applicable in treating acute haemorrhoid, internal hemorrhoid hemorrhage, prolapse and incarceration, perianal abscess, thrombotic external hemorrhoids, mixed hemorrhoid gall, post-surgery anal verge gall and local anal gall in an anti-phlogistic, analgesic and styptic manner; and the medicament of the invention is also applicable as a product for the cleaning and health-care of anus.
Description
Technical field
The present invention relates to medicine with natural plants treatment hemorrhoid.
Technical background
Hemorrhoid are human distinctive disease and common frdquently encountered disease, in people's a certain period in life, all can suffer from the hemorrhoid illness.According to generaI investigation, hemorrhoid account for 78.33% of anus.Symptoms such as hemorrhoid cause has blood in stool, pain, swelling, pruritus, the Health and Living quality that endangers people greatly.The prolonged generation that does not more easily cause rectum, colon cancer of hemorrhoid.
The generation of hemorrhoid is very general, and in treatment, operation, oral medicine treatment have obvious defects.The demibain therapy of anus is in the utilization history in existing thousands of years of China, and the utilization demibain can effectively prevent the generation and the treatment hemorrhoid of anus.Present commercially available hemorrhoid hip bath agent seldom, only sell one or two kind in preparation process, do not adopt anyly heighten the effect of a treatment, extended treatment time and the stable composition that improves the quality.
Chinese patent application 200310116637.9 discloses a kind of " external used medicine and the preparation methoies of treatment hemorrhoid ", and the external used medicine of described treatment hemorrhoid is medicaments of being made by the following weight proportion raw material: Fructus Sophorae 10-250, Radix Notoginseng 8-200, Radix Sophorae Flavescentis 11-275, Pseudobulbus Bletillae (Rhizoma Bletillae) 10-250, Fructus Cnidii 10-250, Herba Patriniae 10-250, Folium Artemisiae Argyi 6.5-162.5, Herba Portulacae 8-200, Flos Lonicerae 6.5-162.5, Radix Saposhnikoviae 6.5-162.5, Alumen 5-125, Borax 5-125, Borneolum Syntheticum 0.5-12.5, Radix Glycyrrhizae 3-75.Described medicine is a dark-brown liquid, is mainly used in treatment of hemorrhoid, is applicable to the fumigation in treating of hemorrhoid outbreak.
Content of the present invention
The object of the present invention is to provide a kind of make with the Modern Pharmaceutical Chemistry theory, drug lotion that can effectively improve the treatment hemorrhoid of curative effect of medication.
The drug lotion of treatment hemorrhoid of the present invention is topical agents of being made by following components by weight ratio: Radix Notoginseng 80, Herba Portulacae 80, Radix Sophorae Flavescentis 110, Pseudobulbus Bletillae (Rhizoma Bletillae) 100, Fructus Cnidii 100, Herba Patriniae 100, Folium Artemisiae Argyi 65, the Fructus Sophorae 100, Flos Lonicerae 65, Radix Saposhnikoviae 65, Alumen 50, Borax 50, Borneolum Syntheticum 5, Radix Glycyrrhizae 30, sodium carboxymethyl cellulose 1-40, polyoxyethylene sorbitan monoleate 0.1-2.
Technical scheme of the present invention is based on the Chinese medicine theory, based on modern organic chemistry theory, with the chelate of the famous and precious hemostasis in Yunnan, blood pain specific drug-Radix Notoginseng extract and sodium carboxymethyl cellulose serve as mainly to treat composition, the topical agent made from modern pharmaceutical technology with the treatment hemorrhoid that clean anus portion, heat clearing and damp drying, dissolving blood stasis and detoxication, hemostasia and detumescence, antalgesic-antipruritic function.
Sodium carboxymethyl cellulose (Carboxymethyl Cellulose; Below be abbreviated as CMC.) be nontoxic, odorless, tasteless, nonirritant, organic compound with specific function purposes.Through repetition test, after sodium carboxymethyl cellulose and the interaction of this preparation of Chinese medicine, can improve the organic polymer between the active ingredient of this preparation greatly, significantly improve therapeutic effect, especially can delay main treatment macromolecular decline of composition arasaponin and resolution speed in this pharmaceutical preparation, reducing drug precipitation, when improving physical stability with the effective ingredient chelating, bond together, thereby effectively improve medicine effective concentration; The binding time of prolong drug and diseased region or target cell helps the performance of medicine maximum therapy effect.The most important thing is, CMC can with the main hemostatic compositions dencichine chelating of Radix Notoginseng in the prescription, generate that the better chemical compound of haemostatic effect--the dencichine sodium salt makes haemostatic effect more remarkable.The addition of sodium carboxymethyl cellulose is different and different with the place of production of Radix Notoginseng, collecting season and a number (number of Radix Notoginseng in every jin, a traditional unit of weight), because above factor all can influence the content of arasaponin, the addition of sodium carboxymethyl cellulose very little, the effect of chelating also with regard to relative mistake some.If but addition is excessive, then can increase the viscosity of whole lotion.In general addition just produces effect more than 0.1 gram in the 1000ml lotion, is advisable with 1-40, and 10-30 is better.Polysorbate is an antiseptic, and addition is advisable effectively to prevent the medicine corruption.
Medicine of the present invention is mainly used in the hemorrhoid acute attack, and Internal hemorrhoid hemorrhage is deviate from, incarceration, perianal abscess, thrombosed external hemorrhoid, mixed hemorrhoid swell and ache, the detumescence of postoperative anus edge, the antiinflammatory of anus partial gall, pain relieving, hemostatic treatment.Also can be used as the best product of anus portion cleaning, health care.
Pharmacodynamics test of the present invention and quality stability test:
One, quality stability test
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Censorship medicine: 1, this pharmaceutical preparation (prescription: CMC 18g, Polysorbate 1, Radix Notoginseng 80g, Herba Portulacae 80g, Radix Sophorae Flavescentis 110g, Pseudobulbus Bletillae (Rhizoma Bletillae) 100g, Fructus Cnidii 100g, Herba Patriniae 100g, Folium Artemisiae Argyi 65g, Fructus Sophorae 100g, Flos Lonicerae 65g, Radix Saposhnikoviae 65g, Alumen 50g, Borax 50g, Borneolum Syntheticum 5g, Radix Glycyrrhizae 30g).2, the said medicine preparation that does not add CMC.
Test method: be encapsulated in two kinds of censorship medicines in the vial respectively, 10 bottles of every kind of medicines, press medicine accelerated stability test principle, character, arasaponin macromole precipitate to two kinds of medicines carry out observing in 6 months, according to the qualitative and quantitative analysis of arasaponin in character variation, precipitate sedimentation time, quantity, the precipitate, carry out the medicine stability evaluation.
※ (through efficient liquid phase chromatographic analysis, Radix Notoginseng total arasaponins content is 0.8-1.6mg/g in the precipitate)
Conclusion: this pharmaceutical preparation does not see that at viewing duration precipitate is arranged, and sensory properties is better; The pharmaceutical preparation that does not add CMC just has precipitate gradually after placing 12 hours in 0th month, sensory properties is not good.The quality stability that shows this pharmaceutical preparation is better; This is because CMC can be an one with the good chelating of arasaponin macromole effective ingredient of one of hemostasis and pain-relieving Main Ingredients and Appearance in the medicament, thereby significantly reduces stability and therapeutic effect that the therapeutic component sedimentation improves medicament.
Two, the test of treatment time
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Censorship medicine: 1, this pharmaceutical preparation (it is the same to fill a prescription).2, the said medicine preparation that does not add CMC.
Test method: get 2 in clean glass (3x5cm), drawing two kinds of each 1.5g of test medicine respectively puts on the slide, slide is made 65 degree tilt, weighing in the time of 5,10,15,20,25 minutes breaks away from the medicament of slide, and calculates the medicament weight that stays in slide with this.Along with time lengthening, the quantity of medicament can reduce gradually on the slide, rests on medicament on the slide and speaks more bright longly more with the diseased region binding time more, according to the quantity of medicament on the different time slide, judges medicament and diseased region binding time.
The results are shown in Figure 1.
Conclusion: this pharmaceutical preparation still had 1/3rd medicaments to adhere on the slide in the time of 25 minutes, and the pharmaceutical preparation that does not add CMC almost all broke away from slide in the time of 20 minutes.CMC dencichine chelating medicine has improved the caking property of medicine and object, has prolonged the binding time with diseased region, has strengthened curative effect.
Three, the arasaponin dissolution rate detects in the medicament
Arasaponin dissolution rate and do not form the saponin content analysis (high performance liquid chromatograph detections) in the precipitate before the chelate in two kinds of pharmaceutical preparatioies (ditto) is respectively sampling detection in 12,24,36 hours.
Conclusion: according to result of the test, after 24 hours, the dissolution rate of Radix Notoginseng total arasaponins does not have the pharmaceutical preparation height of CMC in this pharmaceutical preparation, and the result error that the day part sampling detects is less; Precipitate is less, and the content of Radix Notoginseng total arasaponins is far below simple Chinese medicine mixture group in the precipitate, and the content of Radix Notoginseng total arasaponins is up to 1.11-1.94mg/g in the precipitate.CMC can form the chelating body with the arasaponin macromole effective ingredient of one of hemostasis and pain-relieving Main Ingredients and Appearance in the medicament, thereby significantly reduces stability and therapeutic effect that the therapeutic component sedimentation improves medicament.
Four, blood drug level (alkaloid) determination test
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Censorship medicine: 1, this pharmaceutical preparation (it is the same to fill a prescription).2, the said medicine preparation that does not add CMC.
Laboratory animal: the SD rat is provided by animal housing of unming Medical College
Test method: get 20 of qualified rats, (150 ± 15g), male and female half and half are divided into 2 groups to body weight at random, it is the Chinese medicine combined group of this medicament group and no CMC, press the clinical administration approach, each group adopts rectum to include administration in, and with an amount of aseptic cotton balls and immobilization with adhesive tape, after making medicine and mucous membrane of rectum fully contacting 30 minutes, with 1,2,4,6,8,10,12,14 hour extraction rat ears venous blood, make blood drug level (alkaloid total amount) and measure, judge medicine effective concentration with meansigma methods.
The results are shown in Figure 2.
Conclusion: according to measurement result, this medicament reached the blood drug level peak at 6 hours, keep better average level during 2-10 hour, and blood drug level is far above the simple medicament mixed group of no CMC, and drug half-life prolongs, and medicine effective concentration increases.
Five, clotting time of mice determination test
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Medicine name: Radix Notoginseng extract in this prescription---dencichine aqueous solution is divided into 2 parts, and a copy of it is without the CMC chelating.
Prescription is the same.
Experimental animal: the ICR mice is provided by animal housing of unming Medical College.
Test method: get 30 of 18-22g healthy mices, male and female half and half are divided into 3 groups at random, i.e. the blank group of normal saline, dencichine aqueous solution group and CMC group.Adopt one time the gastric infusion mode, press the administration of 0.5ml/20g body weight, after the administration 1 hour, with very sharp shears in the mouse tail tip upwards about 1cm place cut off afterbody fast, and clock with stopwatch immediately, every 30s inhales effusive blood with filter paper.Begin to be mice during this period of time and cut the tail bleeding time from cutting tail to stopped bleeding.
| Mus number | Blank group min | Dencichine group min | CMC organizes |
| 1 | 15.03 | 9.45 | 5.93 |
| 2 | 13.20 | 6.83 | 5.23 |
| 3 | 14.20 | 5.64 | 6.44 |
| 4 | 10.96 | 7.28 | 5.24 |
| 5 | 9.56 | 7.82 | 4.56 |
| 6 | 10.85 | 8.72 | 6.58 |
| 7 | 12.44 | 8.65 | 4.92 |
| 8 | 8.69 | 7.41 | 5.98 |
| 9 | 11.84 | 6.92 | 6.24 |
| 10 | 13.67 | 6.87 | 5.67 |
| On average | 12.04 | 7.55 | 5.68 |
Conclusion: (structure is the main hemostatic compositions dencichine in the Radix Notoginseng: good Blood clotting is arranged β-N-oxalyl group-D-alpha-beta-diaminopropionic acid (β-N-oxalo-D-α β-diaminopropionic acid)); but after acting on mucosa; because all multifactor influences, bioavailability is low.Itself and CMC form the sodium salt chemical compound that is beneficial to absorption, transhipment behind chemical chelating, played better Blood clotting.
Six, rat mucous membrane of rectum, Cavia porcellus intact skin and damaged skin irritation test
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Censorship medicine: this pharmaceutical preparation (it is the same to fill a prescription).
Laboratory animal: SD rat, Cavia porcellus are provided by animal housing of unming Medical College
Experimental technique: 1, the mucous membrane of rectum irritation test is got qualified male SD rat, body weight (150 ± 15g), be divided into 3 groups at random, it is this pharmaceutical preparation group, simple sodium carboxymethyl cellulose group, blank normal saline group, every group 6, every rat gives this hemorrhoid treating medicine aqueous solution and excipient aqueous solution by grouping except that the blank group, by the clinical application approach, adopt rectum to include administration in, and, medicine and mucous membrane of rectum are fully contacted more than the 4h, administration every day 1 time with an amount of aseptic cotton balls and immobilization with adhesive tape, continuous 7 days, observe the rat anus every day and have or not secretions and general situation thereof.After the drug withdrawal 2 days, put to death rat, take out mucous membrane of rectum, perusal.
| Group | The mucous membrane of rectum reaction | Score value | Intensity |
| Second batch the 3rd batch of first preparation group of this medicine | Not having hyperemia, no edema, no erythema, no congestion does not have hyperemia, no edema, no erythema, no congestion and does not have hyperemia, no edema, no erythema, no |
0 0 0 | Nonirritant nonirritant nonirritant |
| Second batch the 3rd batch of simple first CMC group | Not having hyperemia, no edema, no erythema, no congestion does not have hyperemia, no edema, no erythema, no congestion and does not have hyperemia, no edema, no erythema, no |
0 0 0 | Nonirritant nonirritant nonirritant |
| First second batch the 3rd batch of blank group | Not having hyperemia, no edema, no erythema, no congestion does not have hyperemia, no edema, no erythema, no congestion and does not have hyperemia, no edema, no erythema, no |
0 0 0 | Nonirritant nonirritant nonirritant |
2, intact skin and damaged skin irritation test are got secondary cleaning Cavia porcellus, and body weight (180 ± 30) g makes the about 40cm in unhairing district with blade at its back
2, the harmless the wounded in unhairing district finishs whole skin; The unhairing district makes many places " well " font cut with syringe needle, does not injure subcutaneous tissue, so that petechia degree of being to be arranged on the skin, makes damaged skin.Get 80 of satisfactory Cavia porcelluss, divide 4 groups, press the test of single-dose and multiple dosing respectively, paste the wet tissue that contains 1ml this product medicinal liquid at no hair-fields skin, fixing, make blank group with normal saline simultaneously.Single-dose skin irritation test should make medicinal liquid keep somewhere more than the unhairing dermatotome 6h, after the medication with non-irritating warm saline flush away residual liquor, in 1,24,72h observation agents area skin has or not situations such as erythema, edema; The test of multiple dosing skin irritation, every day, logotype 7 days was observed 7 days after stopping using same position administration 3 times.
Single-dose skin irritation result of the test
| Group | The intact skin group reaction | The damaged skin group reaction | Score value | Intensity |
| Second batch the 3rd batch of first preparation group of this medicine | No erythema, no edema do not have erythema, no edema does not have erythema, no edema | No erythema, no edema do not have erythema, no edema does not have erythema, no |
0 0 0 | Nonirritant nonirritant nonirritant |
| First second batch the 3rd batch of blank group | No erythema, no edema do not have erythema, no edema does not have erythema, no edema | No erythema, no edema do not have erythema, no edema does not have erythema, no |
0 0 0 | Nonirritant nonirritant nonirritant |
Multiple dosing skin irritation result of the test
| Group | The intact skin group reaction | The damaged skin group reaction | Score value | Intensity |
| Second batch the 3rd batch of first preparation group of this medicine | No erythema, no edema, smooth no erythema, no edema, smooth no erythema, no edema, smooth | No erythema, no edema, smooth no erythema, no edema, smooth no erythema, no edema, smooth | 0 0 0 | Nonirritant nonirritant nonirritant |
| First second batch the 3rd batch of blank group | No erythema, no edema, smooth no erythema, no edema, smooth no erythema, no edema, smooth | No erythema, no edema, smooth no erythema, no edema, smooth no erythema, no edema, smooth | 0 0 0 | Nonirritant nonirritant nonirritant |
Conclusion: do not see the breakage of mucous membrane of rectum inflammatory in the sodium carboxymethyl cellulose rat mucous membrane of rectum irritation test, mucous membrane of rectum does not have situations such as hyperemia, erythema, edema, congestion, to the mucous membrane of rectum nonirritant.In the guinea pig skin irritation test, after single-dose stimulated, intact skin of Cavia porcellus and damaged skin agents area there is no irritative responses such as erythema, edema, and each organizes 1,24, the irritative response mean scores of 72h point observing time is 0 value; After multiple dosing stimulated, Cavia porcellus intact skin group and damaged skin group there is no erythema, edema irritative response, skin smooth non-pigment calmness, and Cavia porcellus scuffing skin healing is good, and is long by cropping.
Seven, the mice auricle swelling test led to of dimethylbenzene
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Positive control preparation: 1, this pharmaceutical preparation (it is the same to fill a prescription).2, the simple Chinese medicine combined group of no CMC.3, dimethylbenzene, Beijing HTC chemical plant produces
Experimental animal: the ICR mice is provided by animal housing of unming Medical College.
Test method: get 50 of qualified mices, male and female half and half, body weight 18～22g, be divided into 5 groups at random, the simple Chinese medicine combined group, the positive controls that are the high, medium and low dosage group of medicinal liquid of the present invention, handle without CMC, every group 10, be coated with for respectively mouse right ear exterior feature front and back and give 10% xylene solution, the auris dextra exterior feature is coated with respectively and gives normal saline 10ml/kg after 30 minutes, the simple Chinese medicine combined group solution 6.5ml/kg of no CMC, this high doses group 6.0ml/kg, middle dosage group 4.0ml/kg, low dose group 2.0ml/kg puts to death mice behind 2h.Cutting mice two ears and lay disk with the card punch of diameter 8mm, weigh, is the swelling degree with (auris dextra heavy-left ear is heavy), compares with the normal saline group.
| Mice number | The swelling degree (mg) of various dose |
Conclusion: high, medium and low dosage group of this pharmaceutical preparation and the simple Chinese medicine combined group of not having a CMC all have certain inhibitory action to mice auricle swelling, compare (P＜0.01) with the normal saline group significant differences is arranged, this pharmaceutical preparation group does not add the simple Chinese medicine combined group of CMC to be compared, and this preparation is stronger to the inhibitory action of swelling.
Eight, the influence of rat paw edema due to the on Carrageenan
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Positive control preparation: 1, this pharmaceutical preparation (it is the same to fill a prescription).2, the simple Chinese medicine combined group of no CMC.3, carrageenin, the institute of Chinese materia medica, Shenyang provides.
Experimental animal: the SD rat is provided by animal housing of unming Medical College.
Test method: get 50 of qualified male rats, body weight 150～180g is divided into 5 groups at random, the simple Chinese medicine combined group of distilled water group, no CMC, the high, medium and low dosage group of this pharmaceutical preparation.During on-test, measuring the right ankle joint girth of rat (cm) with soft and soggy chi is basic value, and reuse 1% carrageenin causes swollen, every rat 0.05ml.Cause swollen back and embrocate distilled water, simple Chinese medicine combined group, this medicinal liquid of each dosage group without the processing of CMC chemical technology respectively at right back foot, respectively measured one time the ankle joint girth after the administration in 1,2,4,6 hour respectively, calculate swelling value and suppression ratio, take statistics to learn with the t check and handle.
Conclusion: high, medium and low dosage group of this pharmaceutical preparation and the simple Chinese medicine combined group of not having a CMC all have certain inhibitory action to rat paw edema, compare (P＜0.01) with the distilled water group significant differences is arranged, this medicinal liquid on Carrageenan causes rat paw edema obvious inhibitory action, and it is strong that inhibitory action does not have the CMC medicament.
Nine, the mice hot plate method causes the pain test
Medicament sources: Yunnan Mingyang Pharmaceutical Co., Ltd.
Positive control preparation: 1, this pharmaceutical preparation (it is the same to fill a prescription).2, the simple Chinese medicine combined group of no CMC.
Instrument: the equipment station YLS-6B of Shandong Academy of Medical Sciences intelligence hot-plate instrument
Experimental animal: the ICR mice is provided by animal housing of unming Medical College.
Test method: get the 19-20g female mice, use the hot plate dolorimeter, measure mice from putting into hot plate to the pain threshold of sufficient required time (second) occurring licking as this Mus, all mices lick the foot time less than 5 seconds or all give it up greater than 30 seconds or leaper, qualified mice is divided into 5 groups at random, every group 10, administration, 30,60,90,120 minutes pain threshold behind the mensuration medicine.Carry out statistical procedures with the t check.
Conclusion: adopt mice hot plate method result to show that high, medium and low each the dosage group of this pharmaceutical preparation all has analgesic activity, middle and high dosage group (4ml/kg, 6ml/kg) effect is more obvious, compares (P＜0.01) with the blank group and has significant difference.
Sum up: the experimental result demonstration, CMC (structural formula:
) by with prescription in the main hemostatic compositions dencichine of Radix Notoginseng chelating, generate the better chemical compound of haemostatic effect---carboxymethyl-dencichine sodium salt, the modes such as stability, medicine effective concentration and the prolongation of this medicament and diseased region binding time that improve have greatly strengthened this pharmaceutical treatment effect.This pharmaceutical preparation is to mucous membrane of rectum, skin nonirritant, do not see the part and and general toxic reaction; Have obvious anti-inflammatory and anti and press down swelling effect and analgesic effect.Antiinflammatory presses down relatively P＜0.01 of swelling effect and analgesic effect and blank group, and significant difference is arranged; With the medicament group that does not add CMC relatively, antiinflammatory, press down swelling, analgesic effect than obviously, therapeutic effect is stronger.Test shows: this pharmaceutical preparation has improved the valid density of treatment composition greatly because the active ingredient organic chelate is integrated; The binding time of prolong drug and diseased region or target cell; Delay effective ingredient decline sedimentation time and strengthened medicine stability.Thereby in clinical practice, played therapeutical effect fast and effectively.
Description of drawings
Fig. 1 is that medicament is with the diseased region binding time and combine quantity figure.
Fig. 2 is that medicine blood drug level (alkaloid total amount) is measured figure.
Among the figure:
Be the simple Chinese medicine combined group of no CMC,
For this pharmaceutical preparation.
The specific embodiment
The present invention is described further below by embodiment, and embodiment is not used in restriction the present invention.
Embodiment 1, get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol, being concentrated into relative density is 1.0～1.1 (50 ℃), medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 0.1-2 part polyoxyethylene sorbitan monoleate, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain the alcohol amount and reach 60%, stir evenly, left standstill 48 hours, and got supernatant and reclaim ethanol, being concentrated into relative density is 0.9～1.1 (50 ℃), add above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose 10-30 part, stir rapidly; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
Embodiment 2, get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol, being concentrated into relative density is 1.0～1.1 (50 ℃), medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 1 part of polyoxyethylene sorbitan monoleate, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain the alcohol amount and reach 60%, stir evenly, left standstill 48 hours, and got supernatant and reclaim ethanol, being concentrated into relative density is 0.9～1.1 (50 ℃), add 18 parts of above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose, stir; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
Embodiment 3, get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol, being concentrated into relative density is 1.0～1.1 (50 ℃), medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 1.5 parts of polyoxyethylene sorbitan monoleates, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain alcohol amount and reach 60%, stir evenly, left standstill 48 hours, get supernatant and reclaim ethanol, being concentrated into relative density is 0.9～1.1 (50 ℃), adds 5 parts of above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
Embodiment 4, get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol, being concentrated into relative density is 1.0～1.1 (50 ℃), medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 0.5 part of polyoxyethylene sorbitan monoleate, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain the alcohol amount and reach 60%, stir evenly, left standstill 48 hours, and got supernatant and reclaim ethanol, being concentrated into relative density is 0.9～1.1 (50 ℃), add 1 part of above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose, stir rapidly; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
Embodiment 5, get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol, being concentrated into relative density is 1.0～1.1 (50 ℃), medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 2 parts of polyoxyethylene sorbitan monoleates, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of Pseudobulbus Bletillae (Rhizoma Bletillae), 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain the alcohol amount and reach 60%, stir evenly, left standstill 48 hours, and got supernatant and reclaim ethanol, being concentrated into relative density is 0.9～1.1 (50 ℃), add 30 parts of above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose, stir rapidly; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
Claims (1)
1. a drug lotion for the treatment of hemorrhoid is characterized in that it being the topical agent of being made by following components by weight ratio: Radix Notoginseng 80, Herba Portulacae 80, Radix Sophorae Flavescentis 110, Pseudobulbus Bletillae (Rhizoma Bletillae) 100, Fructus Cnidii 100, Herba Patriniae 100, Folium Artemisiae Argyi 65, the Fructus Sophorae 100, Flos Lonicerae 65, Radix Saposhnikoviae 65, Alumen 50, Borax 50, Borneolum Syntheticum 5, Radix Glycyrrhizae 30, sodium carboxymethyl cellulose 1-30, polyoxyethylene sorbitan monoleate 0.1-2; Described topical agent is made by following method: get Borneolum Syntheticum and add an amount of dissolve with ethanol for 5 parts, 50 parts of 50 parts of Alumens, Borax are with the suitable quantity of water dissolving, and be standby; Radix Notoginseng is ground into coarse powder for 80 parts, according to " percolation under Chinese pharmacopoeia fluid extract and the extractum item is made solvent with 70% ethanol, floods to carry out percolation after 24 hours, and diacolation liquid recycling ethanol is 1.0～1.1 when being concentrated into 50 ℃ of relative densities, and medicinal residues are standby; 65 parts of Flos Loniceraes, 100 parts of Fructus Cnidiis, Folium Artemisiae Argyi are extracted volatile oil for 65 parts, and volatile oil adds 0.1-2 part polyoxyethylene sorbitan monoleate, and mixing is standby; Above-mentioned two kinds of medicinal residues merge, decoct with water three times for 30 parts with 100 parts of the Fructuss Sophorae, 110 parts of Radix Sophorae Flavescentiss, 100 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 100 parts of Herba Patriniae, 80 parts of Herba Portulacaes, 65 parts of Radix Saposhnikoviaes, Radix Glycyrrhizae, 2 hours for the first time, 1.5 hours for the second time, 1 hour for the third time, collecting decoction, filter, filtrate be concentrated into crude drug amount ratio be 1: 1, add ethanol and make and contain the alcohol amount and reach 60%, stir evenly, leaving standstill 48 hours, and got supernatant and reclaim ethanol, is 0.9～1.1 when being concentrated into 50 ℃ of relative densities, add above-mentioned standby Borneolum Syntheticum, Alumen, Borax and sodium carboxymethyl cellulose 10-30 part, stir rapidly; Add water and adjust total amount, stir evenly to 1000ml, embedding, sterilization, promptly.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101161430A CN101780218B (en) | 2010-03-02 | 2010-03-02 | Medicinal lotion for treating haemorrhoids |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010101161430A CN101780218B (en) | 2010-03-02 | 2010-03-02 | Medicinal lotion for treating haemorrhoids |
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| CN102920915A (en) * | 2012-10-09 | 2013-02-13 | 云南名扬药业有限公司 | Ointment preparation for treating haemorrhoids and preparation method for ointment preparation |
| CN103550516B (en) * | 2013-10-29 | 2015-10-14 | 王敬源 | A kind of preparation method for the treatment of the medicament of perianal abscess |
| CN106138370A (en) * | 2015-04-08 | 2016-11-23 | 罗彩莲 | A kind of medicine of foot bath treatment hemorrhoid |
| CN104997986A (en) * | 2015-07-16 | 2015-10-28 | 宋继旭 | Traditional Chinese medicine preparation for treating perianal and perirectal abscesses |
| CN112245462A (en) * | 2020-10-15 | 2021-01-22 | 安徽宝华药业有限公司 | Preparation process of folium artemisiae argyi extract in hemorrhoid medicament |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1546127A (en) * | 2003-11-28 | 2004-11-17 | 温先敏 | Externally applied medicine for treating hemorrhoids and preparation method thereof |
| CN101244204A (en) * | 2008-02-02 | 2008-08-20 | 温先敏 | Suppository for treating hemorrhoid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1546127A (en) * | 2003-11-28 | 2004-11-17 | 温先敏 | Externally applied medicine for treating hemorrhoids and preparation method thereof |
| CN101244204A (en) * | 2008-02-02 | 2008-08-20 | 温先敏 | Suppository for treating hemorrhoid |
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