CN112245462A - Preparation process of folium artemisiae argyi extract in hemorrhoid medicament - Google Patents
Preparation process of folium artemisiae argyi extract in hemorrhoid medicament Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A61K2236/30—Extraction of the material
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention discloses a preparation process of a folium artemisiae argyi extract in a hemorrhoid medicament, which relates to the technical field of traditional Chinese medicine preparation and comprises the following steps: the method comprises the following steps: cleaning folium Artemisiae Argyi, sun drying, cutting the sun dried folium Artemisiae Argyi into pieces, and storing in a cool and ventilated place; step two: crushing folium artemisiae argyi to obtain folium artemisiae argyi powder, screening the folium artemisiae argyi powder, pouring the screened folium artemisiae argyi powder into a plurality of cloth bags, weighing the folium artemisiae argyi powder and the cloth bags, removing the weight of the cloth bags to obtain the net weight of the folium artemisiae argyi powder, and performing the third step: placing the cloth bag containing folium Artemisiae Argyi powder into extraction equipment, and heating and reflux-extracting with water-ethanol as extraction solvent for three times to obtain extractive solution. According to the invention, when the folium artemisiae argyi extract is prepared, the folium artemisiae argyi powder is purified and processed by adopting extraction equipment, so that the mechanization and automation in preparation are improved, the extraction efficiency is higher, and the extraction quality is better.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine preparation, and in particular relates to a preparation process of a folium artemisiae argyi extract in a hemorrhoid medicament.
Background
The folium artemisiae argyi is dry leaves of folium artemisiae argyi of a feverfew, the product is more wrinkled and broken and has a short handle, the whole leaves are in an oval shape after being flattened, the pinnate shape is deep-cracked, the split elliptic shape is in a needle shape, irregular coarse sawteeth are arranged on the edge, the folium artemisiae argyi extract is a brown powder product, the dry folium artemisiae argyi medicinal material is used as a raw material, the folium artemisiae argyi is a traditional Chinese medicinal material, the traditional Chinese medicine is mostly decocted in a compound decoction in use and is still a use method of most doctors and hospitals, but the use is still troublesome, the original components of the medicinal material are reserved after the coarse extraction and fine extraction processes, the decocting trouble is reduced, and the efficacy of the.
Chinese patent discloses a folium artemisiae argyi extract and a preparation method and application thereof (publication number: CN108531526B), and the preparation method comprises the following steps: (1) pulverizing dried folium Artemisiae Argyi, sterilizing, placing in sterile fermentation tank, adding glucose and yeast powder, mixing, sealing the fermentation tank, and naturally fermenting at 20-25 deg.C for 20-25 days to obtain fermented product; (2) soaking the fermented product obtained in the step (1) in acetone, filtering, concentrating the filtrate, adsorbing by macroporous resin, eluting with 60-70% ethanol solution by volume fraction, collecting eluate with 5-6 times column volume, decolorizing with active carbon, concentrating, and drying to obtain folium Artemisiae Argyi extract.
In the prior art, the flow of the folium artemisiae argyi extract is tedious, so that the processing efficiency is low, meanwhile, in the processing process, the flow is more, the cost is high, the market competitiveness of the product is poor, in the prior art, the automation and mechanization degrees are low, a large number of steps of staff participation are needed, and the labor intensity of the staff is high.
Disclosure of Invention
In order to overcome the technical problems that the prior art has complicated process of folium artemisiae argyi extract, causes low processing efficiency, has more process and higher cost during processing, causes poor market competitiveness of products, and needs a large number of steps participated by workers due to lower automation and mechanization degrees during preparation of folium artemisiae argyi extract, thereby causing higher labor intensity of the workers, the invention aims to provide the preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament.
The purpose of the invention can be realized by the following technical scheme:
a preparation process of folium Artemisiae Argyi extract in hemorrhoid preparation comprises the following steps:
the method comprises the following steps: cleaning folium Artemisiae Argyi, sun drying, cutting the sun dried folium Artemisiae Argyi into pieces, and storing in a cool and ventilated place;
step two: crushing folium artemisiae argyi to obtain folium artemisiae argyi powder, screening the folium artemisiae argyi powder, pouring the screened folium artemisiae argyi powder into a plurality of cloth bags, weighing the folium artemisiae argyi powder and the cloth bags, removing the weight of the cloth bags to obtain the net weight of the folium artemisiae argyi powder, recording the weight of the folium artemisiae argyi powder in each cloth bag, and calculating the proportion of ethanol and water in an extraction solvent according to the folium artemisiae argyi powder with different weights;
step three: placing the cloth bag filled with folium Artemisiae Argyi powder into an extraction device, heating and reflux-extracting with water-ethanol as extraction solvent for three times to obtain extractive solution, and purifying the extractive solution by pressure concentration to obtain folium Artemisiae Argyi extract;
step four: the mugwort leaf extract is loaded into a raw material tank and stored in a refrigerating chamber.
As a further scheme of the invention: the mesh number of the folium artemisiae argyi powder is 90-100 meshes, and a vibrating screen with 90-110 meshes is used for screening during screening.
As a further scheme of the invention: the temperature during the pressure concentration is 50-55 ℃.
As a further scheme of the invention: the extraction equipment comprises a substrate, wherein a first processing table is fixedly connected to the upper surface of the substrate, a second processing table is fixedly connected to the upper surface of the first processing table, a return tank is fixedly connected to the upper surface of the second processing table, a support frame is fixedly connected to the outer side, close to the return tank, of the upper surface of the second processing table, a powder cloth bag is connected to the inside of the support frame in an adsorption mode, a support table is fixedly connected to one side, close to the return tank, of the upper surface of the second processing table, a liquid mixing tank is fixedly connected to the top end of the support table, and a first connecting pipe is fixedly connected between a liquid outlet of the liquid mixing tank and a liquid inlet of the;
the upper surface fixedly connected with purification case of first processing platform, and one side fixedly connected with vacuum pump that first processing bench upper surface is close to the purification case, through flange fixed connection between the air inlet of vacuum pump and the gas outlet of purification case, the top fixedly connected with ethanol recovery tube of purification case one side, and one side fixedly connected with extract recovery tube of purification case lower surface.
As a further scheme of the invention: the support frame includes two sets of electric telescopic handle, and is two sets of the spiro union has the link between electric telescopic handle's the output, the upper surface and the side of link all imbed and are connected with the second permanent magnet.
As a further scheme of the invention: the upper surface adhesion of powder sack is connected with the linking frame, and powder sack side and lower surface all adhesion are connected with a plurality of first permanent magnet.
As a further scheme of the invention: the last fixed surface of liquid mixing box is connected with communicating pipe, one side fixedly connected with ethanol admission pipe of communicating pipe, and the downside fixedly connected with warm water admission pipe that is close to the ethanol admission pipe in the side of communicating pipe, ethanol admission pipe and warm water admission pipe all are the slope form and distribute, and the contained angle between ethanol admission pipe and warm water admission pipe and the horizontal direction is 30, flowmeter and temperature sensor are all installed to the inside of ethanol admission pipe and warm water admission pipe.
As a further scheme of the invention: the top fixedly connected with water guide plate of liquid mixing box inside, it is connected with the connecting axle to rotate between water guide plate and the liquid mixing box bottom, the top fixedly connected with turbine in the connecting axle outside, and the bottom fixedly connected with stirring roller in the connecting axle outside, one side that liquid mixing box was kept away from to the water guide plate is located the upside at turbine edge.
As a further scheme of the invention: the lower fixed surface of purification case is connected with driving motor, and the bottom of purification incasement portion rotates and is connected with the stirring wheel, driving motor's output and stirring wheel fixed connection, the inner wall embedding of purification case is connected with resistance heater.
As a further scheme of the invention: the use method of the extraction equipment comprises the following steps: putting folium artemisiae argyi powder into a powder cloth bag, then starting an electric telescopic rod in a supporting frame to drive a connecting frame to ascend, putting the powder cloth bag into the connecting frame, adsorbing a connecting frame and a first permanent magnet onto a second permanent magnet in the connecting frame, starting the electric telescopic rod again, and descending the powder cloth bag into a return tank;
the ethanol and the warm water respectively enter the communicating pipe through the ethanol inlet pipe and the warm water inlet pipe, then flow into the liquid mixing box along the communicating pipe, are guided by the water guide plate to flow onto the edge of the turbine when passing through the water guide plate, drive the turbine to rotate when the ethanol and the warm water pass through the turbine, and drive the stirring roller to rotate through the connecting shaft after the turbine rotates, and stir the ethanol and the warm water at the bottom;
after stirring, enabling the ethanol and the warm water to flow into a reflux box through a first connecting pipe, soaking the folium artemisiae argyi powder in the powder cloth bag, discharging the ethanol and the warm water into a purification box through a second connecting pipe after soaking for twenty minutes, repeating the steps, soaking the folium artemisiae argyi powder for two times, discharging the ethanol and the warm water into the purification box for two times, starting a driving motor when soaking the folium artemisiae argyi powder, and stirring the ethanol and the warm water in the purification box through a stirring wheel;
after soaking, starting an electric telescopic rod, taking the powder cloth bag out of a reflux box, taking the powder cloth bag out of a connecting frame, starting a vacuum pump, vacuumizing a purification box, starting a resistance heater, keeping the temperature in the purification box, discharging ethanol from an ethanol recovery pipe in a vacuum state, repeating the steps after the pressure in the purification box is recovered, pumping the purification box to a vacuum state, continuously discharging the ethanol, finally starting an extract recovery pipe, discharging the extract from the purification box, and then evaporating and purifying the extract at high temperature;
the electromagnetic valves are arranged at the connecting parts of the first connecting pipe, the second connecting pipe, the ethanol recovery pipe, the extracting solution recovery pipe and the purifying box and the vacuum pump, when the liquid mixing box works, the electromagnetic valve in the first connecting pipe is closed, when the electromagnetic valve in the first connecting pipe is opened, ethanol and warm water in the liquid mixing box are discharged into the return box, when the electromagnetic valve in the second connecting pipe is opened, the ethanol and the warm water are discharged into the purifying box along the second connecting pipe, when the electromagnetic valve in the ethanol recovery pipe is opened, ethanol gas is discharged out of the purifying box along the ethanol recovery pipe, when the liquid in the extracting solution recovery pipe is opened, extracting solution is discharged out of the purifying box along the extracting solution recovery pipe, and when the electromagnetic valve at the connecting part of the purifying box and the vacuum pump is closed, the purifying box keeps the internal pressure.
The invention has the beneficial effects that:
1. compared with the prior art, the method has the advantages that the extraction equipment is adopted to purify and process the folium artemisiae argyi powder, so that the mechanization and automation in preparation are improved, the extraction efficiency is higher, and the extraction quality is better.
2. When the liquid mixing box works, the internal mixing component can be driven to work by the flow velocity of the ethanol and the warm water, so that the ethanol and the warm water can be conveniently mixed, and the reflux efficiency and quality can be improved.
3. In the confluence box, the support frame is adopted, the support frame is convenient for moving the powder cloth bag, the powder cloth bag is fixed in a magnetic suction mode, the powder cloth bag can be unfolded during processing, the contact area of the folium artemisiae argyi powder and the extraction solvent is increased, and the adsorption connection is convenient for workers to replace the powder cloth bag.
Drawings
The invention will be further described with reference to the accompanying drawings.
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the construction of the reflow oven and the support bracket of the present invention;
FIG. 3 is a schematic view of the construction of the powder cloth bag of the present invention;
FIG. 4 is a cross-sectional view of the liquid mixing tank of the present invention;
fig. 5 is a sectional view of the purifying tank of the present invention.
In the figure: 1. a substrate; 2. a first processing table; 3. a second processing table; 4. a return tank; 5. a support frame; 6. a powder cloth bag; 7. a support table; 8. a liquid mixing tank; 9. a first connecting pipe; 10. a purification box; 11. a vacuum pump; 12. a second connecting pipe; 13. an ethanol recovery pipe; 14. an extract recovery pipe; 15. a connecting frame; 16. a first permanent magnet; 17. a communicating pipe; 18. an ethanol inlet pipe; 19. warm water inlet pipe; 20. a water guide plate; 21. a connecting shaft; 22. a turbine; 23. a stirring roller; 24. a drive motor; 25. a stirring wheel; 26. a resistance heater; 51. an electric telescopic rod; 52. a connecting frame; 53. a second permanent magnet.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-5, a process for preparing an artemisia leaf extract in a hemorrhoid treatment agent includes the following steps:
the method comprises the following steps: cleaning folium Artemisiae Argyi, sun drying, cutting the sun dried folium Artemisiae Argyi into pieces, and storing in a cool and ventilated place;
step two: crushing folium artemisiae argyi to obtain folium artemisiae argyi powder, screening the folium artemisiae argyi powder by using a vibrating screen with 90-110 meshes during screening, wherein the mesh number of the folium artemisiae argyi powder is 90-100 meshes, pouring the screened folium artemisiae argyi powder into a plurality of cloth bags, weighing the folium artemisiae argyi powder and the cloth bags, removing the weight of the cloth bags to obtain the net weight of the folium artemisiae argyi powder, and recording the weight of the folium artemisiae argyi powder in each cloth bag;
step three: placing the cloth bag filled with folium Artemisiae Argyi powder into extraction equipment, heating and reflux-extracting with water-ethanol as extraction solvent for three times to obtain extractive solution, and purifying the extractive solution by pressure concentration at 50 deg.C to obtain folium Artemisiae Argyi extract;
step four: the mugwort leaf extract is loaded into a raw material tank and stored in a refrigerating chamber.
Referring to fig. 1, the extraction equipment includes a substrate 1, a first processing table 2 is fixedly connected to the upper surface of the substrate 1, a second processing table 3 is fixedly connected to the upper surface of the first processing table 2, a return tank 4 is fixedly connected to the upper surface of the second processing table 3, a support frame 5 is fixedly connected to the outer side of the upper surface of the second processing table 3 close to the return tank 4, a powder cloth bag 6 is connected to the inside of the support frame 5 in an adsorption manner, a support table 7 is fixedly connected to one side of the upper surface of the second processing table 3 close to the return tank 4, a liquid mixing tank 8 is fixedly connected to the top end of the support table 7, and a first connecting pipe 9 is fixedly connected between the liquid outlet of the liquid mixing tank 8 and the liquid inlet;
Please refer to fig. 2-3, the support frame 5 includes two sets of electric telescopic rods 51, the spiro union has the link 52 between the output of two sets of electric telescopic rods 51, the upper surface and the side of link 52 all imbed and are connected with the second permanent magnet 53, the upper surface adhesion of powder sack 6 is connected with the connection frame 15, and the equal adhesion of powder sack 6 side and lower surface is connected with the first permanent magnet 16 of a plurality of, the support frame 5 conveniently removes the powder sack 6, and the powder sack 6 adopts the mode of magnetism to fix, when processing, can launch the powder sack 6, increase folium artemisiae argyi powder and the area of contact who draws the solvent, and adsorb and connect and make things convenient for the staff to change the powder sack.
Referring to fig. 4, a communicating pipe 17 is fixedly connected to the upper surface of the liquid mixing box 8, an ethanol inlet pipe 18 is fixedly connected to one side of the communicating pipe 17, a warm water inlet pipe 19 is fixedly connected to the lower side of the communicating pipe 17, which is close to the ethanol inlet pipe 18, the ethanol inlet pipe 18 and the warm water inlet pipe 19 are both distributed in an inclined manner, an included angle between the ethanol inlet pipe 18 and the warm water inlet pipe 19 and the horizontal direction is 30 °, a flow meter and a temperature sensor are both installed inside the ethanol inlet pipe 18 and the warm water inlet pipe 19, the temperature sensor is JCJ175A type, the flow meter is YL-LDE type, a water guide plate 20 is fixedly connected to the top end inside the liquid mixing box 8, a connecting shaft 21 is rotatably connected between the water guide plate 20 and the bottom of the liquid mixing box 8, a turbine 22 is fixedly connected to the top end outside the connecting shaft 21, one side that water deflector 20 kept away from liquid mixing box 8 is located the upside at turbine 22 edge, and at the during operation, can drive inside mixing component through the velocity of flow of ethanol and warm water self and carry out work to conveniently mix ethanol and warm water, thereby can improve the efficiency and the quality of backward flow.
Referring to fig. 5, a driving motor 24 is fixedly connected to the lower surface of the purification box 10, the driving motor 24 is 40W-90 type and is provided with a locking structure and a decelerating structure, the stirring wheel 25 is rotatably connected to the bottom end inside the purification box 10, the output end of the driving motor 24 is fixedly connected to the stirring wheel 25, and the resistance heater 26 is embedded and connected to the inner wall of the purification box 10.
The working principle of the extraction equipment in the invention is as follows: the folium artemisiae argyi powder is filled into a powder cloth bag 6, then an electric telescopic rod 51 in a support frame 5 is started, the electric telescopic rod 51 is of an XTL100 type, a connecting frame 52 is driven to ascend, the powder cloth bag 6 is placed into the connecting frame 52, a connecting frame 15 and a first permanent magnet 16 are adsorbed onto a second permanent magnet 53 in the connecting frame 52, then the electric telescopic rod 51 is started, and the powder cloth bag 6 is lowered into a backflow box 4;
the ethanol and the warm water respectively enter the communicating pipe 17 through the ethanol inlet pipe 18 and the warm water inlet pipe 19, then flow into the liquid mixing box 8 along the communicating pipe 17, are guided by the water guide plate 20 to flow onto the edge of the turbine 22 when passing through the water guide plate 20, drive the turbine 22 to rotate when the ethanol and the warm water pass through the turbine 22, and drive the stirring roller 23 to rotate through the connecting shaft 21 after the turbine 22 rotates, and stir the ethanol and the warm water at the bottom;
the stirred ethanol and warm water flow into the reflux box 4 through the first connecting pipe 9, the folium artemisiae argyi powder in the powder cloth bag 6 is soaked, after twenty minutes of soaking, the ethanol and warm water are discharged into the purification box 10 through the second connecting pipe 12, then the steps are repeated, the folium artemisiae argyi powder is soaked for two times, the ethanol and warm water in the two times are discharged into the purification box 10, when the folium artemisiae argyi powder is soaked, the driving motor 24 is started, and the ethanol and warm water in the purification box 10 are stirred through the stirring wheel 25;
after soaking, starting the electric telescopic rod 51, taking the powder cloth bag 6 away from the reflux box 4, taking the powder cloth bag 6 out of the connecting frame 52, starting the vacuum pump 11, vacuumizing the purification box 10, starting the resistance heater 26, keeping the temperature in the purification box 10, evaporating ethanol and discharging the ethanol from the ethanol recovery pipe 13 in the vacuum state, repeating the steps after the pressure in the purification box 10 is recovered, extracting the purification box 10 to the vacuum state, continuously discharging the ethanol, finally starting the extract recovery pipe 14, discharging the extract from the purification box 10, and then evaporating and purifying the extract at high temperature;
the first connecting pipe 9, the second connecting pipe 12, the ethanol recovery pipe 13, the extract recovery pipe 14 and the purification tank 10 are each provided with a solenoid valve at a portion connected to the vacuum pump 11, when the liquid mixing tank 8 is operated, the solenoid valve in the first connecting pipe 9 is closed, when the solenoid valve in the first connecting pipe 9 is opened, ethanol and warm water in the liquid mixing tank 8 are discharged into the reflux tank 4, when the solenoid valve in the second connecting pipe 12 is opened, ethanol and warm water are discharged into the purification tank 10 along the second connecting pipe 12, when the solenoid valve in the ethanol recovery pipe 13 is opened, ethanol gas is discharged out of the purification tank 10 along the ethanol recovery pipe 13, when the liquid in the extract recovery pipe 14 is opened, extract is discharged out of the purification tank 10 along the extract recovery pipe 14, when the solenoid valve at a portion connected to the vacuum pump 11, the solenoid valve in the ethanol recovery pipe 13 and the solenoid valve in the extract recovery pipe 14 are closed, purification tank 10 maintains the internal pressure.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is illustrative and explanatory only and is not intended to be exhaustive or to limit the invention to the precise embodiments described, and various modifications, additions, and substitutions may be made by those skilled in the art without departing from the scope of the invention or exceeding the scope of the claims.
Claims (10)
1. A preparation process of a folium artemisiae argyi extract in a hemorrhoid medicament is characterized by comprising the following steps:
the method comprises the following steps: cleaning folium Artemisiae Argyi, sun drying, cutting the sun dried folium Artemisiae Argyi into pieces, and storing in a cool and ventilated place;
step two: crushing folium artemisiae argyi to obtain folium artemisiae argyi powder, screening the folium artemisiae argyi powder, pouring the screened folium artemisiae argyi powder into a plurality of cloth bags, weighing the folium artemisiae argyi powder and the cloth bags, removing the weight of the cloth bags to obtain the net weight of the folium artemisiae argyi powder, and recording the weight of the folium artemisiae argyi powder in each cloth bag;
step three: placing the cloth bag filled with folium Artemisiae Argyi powder into an extraction device, heating and reflux-extracting with water-ethanol as extraction solvent for three times to obtain extractive solution, and purifying the extractive solution by pressure concentration to obtain folium Artemisiae Argyi extract;
step four: the mugwort leaf extract is loaded into a raw material tank and stored in a refrigerating chamber.
2. The process for preparing the artemisia leaf extract in the hemorrhoid agent according to claim 1, wherein the mesh number of the artemisia leaf powder is 90-100 meshes, and a vibrating screen with 90-110 meshes is used for screening.
3. The process for preparing the artemisia leaf extract in the hemorrhoid agent according to claim 1, wherein the temperature during the pressure concentration is 50-55 ℃.
4. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 1, wherein the extraction equipment comprises a substrate (1), a first processing table (2) is fixedly connected to the upper surface of the substrate (1), a second processing table (3) is fixedly connected to the upper surface of the first processing table (2), a reflux box (4) is fixedly connected to the upper surface of the second processing table (3), a support frame (5) is fixedly connected to the outer side, close to the reflux box (4), of the upper surface of the second processing table (3), a powder cloth bag (6) is connected to the inner portion of the support frame (5) in an adsorption mode, a support table (7) is fixedly connected to one side, close to the reflux box (4), of the upper surface of the second processing table (3), a liquid mixing box (8) is fixedly connected to the top end of the support table (7), and a first connecting pipe (9) is fixedly connected between the liquid outlet of the liquid mixing box (8) and the liquid inlet of the reflux box ( (ii) a
The upper surface fixedly connected with purification case (10) of first processing platform (2), and one side fixedly connected with vacuum pump (11) that first processing platform (2) upper surface is close to purification case (10), through flange fixed connection between the air inlet of vacuum pump (11) and the gas outlet of purification case (10), top fixedly connected with ethanol recovery tube (13) of purification case (10) one side, and one side fixedly connected with extract recovery tube (14) of purification case (10) lower surface.
5. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 4, wherein the support frame (5) comprises two groups of electric telescopic rods (51), a connecting frame (52) is in threaded connection between the output ends of the two groups of electric telescopic rods (51), and a second permanent magnet (53) is embedded and connected on the upper surface and the side surface of the connecting frame (52).
6. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 4, wherein the upper surface of the powder cloth bag (6) is connected with a connecting frame (15) in an adhering mode, and the side surface and the lower surface of the powder cloth bag (6) are connected with a plurality of first permanent magnets (16) in an adhering mode.
7. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 4, wherein the upper surface of the liquid mixing box (8) is fixedly connected with a communicating pipe (17), one side of the communicating pipe (17) is fixedly connected with an ethanol inlet pipe (18), the side surface of the communicating pipe (17) is close to a warm water inlet pipe (19) fixedly connected with the lower side of the ethanol inlet pipe (18), the ethanol inlet pipe (18) and the warm water inlet pipe (19) are both distributed in an inclined manner, an included angle between the ethanol inlet pipe (18) and the warm water inlet pipe (19) and the horizontal direction is 30 degrees, and a flow meter and a temperature sensor are respectively installed inside the ethanol inlet pipe (18) and the warm water inlet pipe (19).
8. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 7, wherein a water guide plate (20) is fixedly connected to the top end of the inside of the liquid mixing box (8), a connecting shaft (21) is rotatably connected between the water guide plate (20) and the bottom of the liquid mixing box (8), a turbine (22) is fixedly connected to the top end of the outer side of the connecting shaft (21), a stirring roller (23) is fixedly connected to the bottom end of the outer side of the connecting shaft (21), and one side, away from the liquid mixing box (8), of the water guide plate (20) is located on the upper side of the edge of the turbine (22).
9. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 4, wherein a driving motor (24) is fixedly connected to the lower surface of the purification box (10), a stirring wheel (25) is rotatably connected to the bottom end inside the purification box (10), the output end of the driving motor (24) is fixedly connected with the stirring wheel (25), and a resistance heater (26) is embedded and connected to the inner wall of the purification box (10).
10. The preparation process of the folium artemisiae argyi extract in the hemorrhoid medicament according to claim 4, wherein the using method of the extraction equipment comprises the following steps: the folium artemisiae argyi powder is filled into a powder cloth bag (6), then an electric telescopic rod (51) in a support frame (5) is started to drive a connecting frame (52) to ascend, the powder cloth bag (6) is placed into the connecting frame (52), a connecting frame (15) and a first permanent magnet (16) are adsorbed onto a second permanent magnet (53) in the connecting frame (52), then the electric telescopic rod (51) is started, and the powder cloth bag (6) is descended into a backflow box (4);
ethanol and warm water respectively enter a communicating pipe (17) through an ethanol inlet pipe (18) and a warm water inlet pipe (19), then flow into a liquid mixing box (8) along the communicating pipe (17), flow onto the edge of a turbine (22) under the guidance of a water guide plate (20) when passing through the water guide plate (20), drive the turbine (22) to rotate when the ethanol and the warm water pass through the turbine (22), and drive a stirring roller (23) to rotate through a connecting shaft (21) after the turbine (22) rotates, and stir the ethanol and the warm water at the bottom;
the stirred ethanol and warm water flow into a reflux box (4) through a first connecting pipe (9), folium artemisiae argyi powder in a powder cloth bag (6) is soaked, after twenty minutes of soaking, the ethanol and warm water are discharged into a purification box (10) through a second connecting pipe (12), then the steps are repeated, the folium artemisiae argyi powder is soaked for two times, the ethanol and the warm water in the two times are discharged into the purification box (10), when the folium artemisiae argyi powder is soaked, a driving motor (24) is started, and the ethanol and the warm water in the purification box (10) are stirred through a stirring wheel (25);
after soaking, starting an electric telescopic rod (51), taking the powder cloth bag (6) away from a reflux box (4), taking the powder cloth bag (6) out of a connecting frame (52), starting a vacuum pump (11), vacuumizing a purification box (10), starting a resistance heater (26), keeping the temperature in the purification box (10), evaporating ethanol and discharging the ethanol from an ethanol recovery pipe (13) in a vacuum state, repeating the steps after the pressure in the purification box (10) is recovered, extracting the purification box (10) to a vacuum state, continuously discharging the ethanol, finally starting an extract recovery pipe (14), discharging the extract from the purification box (10), and then evaporating and purifying the extract at high temperature;
electromagnetic valves are arranged at the connecting parts of the first connecting pipe (9), the second connecting pipe (12), the ethanol recycling pipe (13), the extracting solution recycling pipe (14) and the purifying tank (10) and the vacuum pump (11), when the liquid mixing tank (8) works, the electromagnetic valve in the first connecting pipe (9) is closed, when the electromagnetic valve in the first connecting pipe (9) is opened, ethanol and warm water in the liquid mixing tank (8) are discharged into the reflux tank (4), when the electromagnetic valve in the second connecting pipe (12) is opened, the ethanol and warm water are discharged into the purifying tank (10) along the second connecting pipe (12), when the electromagnetic valve in the ethanol recycling pipe (13) is opened, ethanol gas is discharged out of the purifying tank (10) along the ethanol recycling pipe (13), when the liquid in the extracting solution recycling pipe (14) is opened, extracting solution is discharged out of the purifying tank (10) along the extracting solution recycling pipe (14), when the solenoid valve at the connection portion of the purification tank (10) and the vacuum pump (11) is closed, the purification tank (10) maintains the internal pressure.
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Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994257A (en) * | 2005-12-31 | 2007-07-11 | 徐桂英 | A Chinese medicine extraction equipment |
| CN101780218A (en) * | 2010-03-02 | 2010-07-21 | 温先敏 | Medicinal lotion for treating haemorrhoids |
| CN104983984A (en) * | 2015-08-04 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Medicine composite for treating haemorrhoids and preparation method thereof |
| CN105079726A (en) * | 2015-10-12 | 2015-11-25 | 临沂草之美医药科技有限公司 | Medicine composition for treating hemorrhoids and preparation method thereof |
| CN105412385A (en) * | 2015-09-30 | 2016-03-23 | 罗奕珺 | Pharmaceutical composition for treating hemorrhoids |
| CN108905279A (en) * | 2018-08-10 | 2018-11-30 | 济南爱思医药科技有限公司 | A kind of herbal extraction equipment and extracting method |
| CN209500874U (en) * | 2018-12-20 | 2019-10-18 | 昂力喜(天津)生物技术有限责任公司 | A kind of efficient herbal extraction equipment |
-
2020
- 2020-10-15 CN CN202011105609.7A patent/CN112245462A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1994257A (en) * | 2005-12-31 | 2007-07-11 | 徐桂英 | A Chinese medicine extraction equipment |
| CN101780218A (en) * | 2010-03-02 | 2010-07-21 | 温先敏 | Medicinal lotion for treating haemorrhoids |
| CN104983984A (en) * | 2015-08-04 | 2015-10-21 | 青岛蓝盛洋医药生物科技有限责任公司 | Medicine composite for treating haemorrhoids and preparation method thereof |
| CN105412385A (en) * | 2015-09-30 | 2016-03-23 | 罗奕珺 | Pharmaceutical composition for treating hemorrhoids |
| CN105079726A (en) * | 2015-10-12 | 2015-11-25 | 临沂草之美医药科技有限公司 | Medicine composition for treating hemorrhoids and preparation method thereof |
| CN105878927A (en) * | 2015-10-12 | 2016-08-24 | 烟台市蓝洋之草医药生物科技有限公司 | Method for preparing medical composition capable of treating haemorrhoid |
| CN108905279A (en) * | 2018-08-10 | 2018-11-30 | 济南爱思医药科技有限公司 | A kind of herbal extraction equipment and extracting method |
| CN209500874U (en) * | 2018-12-20 | 2019-10-18 | 昂力喜(天津)生物技术有限责任公司 | A kind of efficient herbal extraction equipment |
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Application publication date: 20210122 |