CN101775029A - Convenient synthesis method for alkyl substitution phenyloboricacid - Google Patents
Convenient synthesis method for alkyl substitution phenyloboricacid Download PDFInfo
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- CN101775029A CN101775029A CN200910042485A CN200910042485A CN101775029A CN 101775029 A CN101775029 A CN 101775029A CN 200910042485 A CN200910042485 A CN 200910042485A CN 200910042485 A CN200910042485 A CN 200910042485A CN 101775029 A CN101775029 A CN 101775029A
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- boric acid
- alkyl
- substituted benzene
- alkyl substituted
- trialkylboron
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Abstract
The invention provides a convenient preparation technique for alkyl substitution phenyloboricacid, belonging to the technical field of organic boric acid compounds in fields such as medicine, pesticide, material, biological sensing detection and the like. The main technical scheme is as follows: traditional Grignard reagent preparation and low temperature nucleophilic substitution are integrated into one step, one-pot preparation; product yield is high, reaction condition is mild, reaction time is shortened by half, and solvent amount is reduced by half; production equipment is simplified, and production cost is reduced.
Description
Technical field:
The invention belongs to the technical field of organic boronic compound production preparation, related in particular to a kind of easy synthesis technique of alkyl substituted benzene boric acid.
Background technology:
Alkyl substituted benzene boric acid is the boronic acid compounds that is replaced by one or more groups on single phenyl ring, the phenylo boric acid that various alkyl replace is important organic synthesis intermediate and medicine, pesticide intermediate, all is widely used in electronics, chemistry, medicine, biology, preparation bioactive agents, investigation of materials.On biology, medical science or materialogy, the selectivity that alkyl substituted benzene boric acid has been used to the transmitter of hydro carbons, artificial Sugar receptors (borono-Sugar receptors) target cell surface carbohydrate, nucleosides and carbohydrate transports the inhibitor of carrier, enzyme and be used as therapeutical agent etc. in some brain tumor patient's boron neutron capture therapy method.
Because increasing to their applied research, range of application constantly enlarges. the kind of alkyl substituted benzene boronic acid compounds is more and more.The synthetic method of alkyl substituted benzene boric acid series compound mainly contains three kinds: the organolithium reagent method; The Grignard reagent method; Palladium Catalytic Oxygen boryl method.The application in alkyl substituted benzene boric acid synthetic of organolithium method is more extensive, weak point is that nucleophilic substitution reaction will carry out under-78 ℃～-40 ℃ low temperatures, and use costliness and the adventurous organolithium that operates, generally can not be used for the phenylo boric acid of synthetic cyano-containing, ester group etc.Palladium Catalytic Oxygen boryl method, the reaction conditions gentleness does not need low temperature, need not the oxygen barrier water proof; Allow reactant to contain cyano group, nitro, amino, hydroxyl, ester group or carbonyl etc.; From aryl halide one step preparation aryl-boric acid ester.But be to use expensive catalyzer, and under some situation, issuable heavy metal contamination also is serious problems.The Grignard reagent method scope of application is wider, the phenylo boric acid that various alkyl/alkoxyl group replaces, as 2,6-dimethyl benzene boric acid, o-methyl-benzene boric acid, adjacent ethylbenzene boric acid, 4-isopropyl benzene boric acid, 2, all available these methods such as 3-two positive propoxy phenylo boric acids, 3-methoxyphenylboronic acid, 4-(2-isobutoxy) phenylo boric acid are synthetic.The substituted benzene boric acid elder generation of containing reactive groups such as hydroxyl on the phenyl ring protects reactive group resynthesis phenylo boric acid, and transforming blocking group again after synthesizing is reactive group, also available this Grignard preparation; Being connected with nitro etc. on the phenyl ring causes behind the often synthetic earlier phenylo boric acid of substituted benzene boric acid of blunt group nitrated again.Compare with organolithium reagent method, palladium Catalytic Oxygen boryl method, the Grignard reagent legal system is on the waiting list for phenylo boric acid, raw material be easy to get and price more cheap, operation is handy and safe relatively also.Also need significantly improve the nucleophilic substitution temperature but be used for actual production, shorten the reaction times, make lithium aryl earlier under-78 ℃ as employing organolithium methods such as Anne Marie Schoevaars, ℃ following nucleophilic substitution has obtained 51% product yield then-50; Barrish etc. are raw material with the trimethyl borate when inhibitor imidazole quinoline for preparing protein tyrosine kinase and their salt, adopt Grignard reagent-78 a ℃ following nucleophilic substitution to make 2,6-dimethyl benzene boric acid, but productive rate is undeclared.The applicant is to 2, and 6-dimethyl benzene boric acid has also carried out process modification, utilize Grignard to adopt different boronating agents to react after, the reaction conditions gentleness, yield increases substantially.
1986, Brown, H.C etc. utilized organoboron compound, magnesium, boron trifluoride ether solution one pot reaction at room temperature, produced in high yields trialkylborane.Nineteen ninety-five, Huang Shiwen etc. improve the Grignard reagent method, adopt the synthetic many virtues of one kettle way (mixing) ring boric acid, the drips of solution that will contain the many virtues of halo (mixing) ring, tri-n-butyl borate adds in the magnesium chips suspension, react 3-4h down at 40 ℃, through acidic hydrolysis etc. product, the isolated yield 48% of phenylo boric acid wherein, α-thienyl boric acid isolated yield 55%.Pacify loyal peacekeeping Chen new recruit and reported " one pot " synthetic method of polycyclic aromatic hydrocarbons list substituted boracic acid.With the boron trifluoride ether solution is boronation reagent, productive rate 40%～60%.These reports are improved similar reaction, but have a lot of problems, and yield is low on the one hand, be difficult to realize industrialization, and separation difficulty, very easy generation hypoboric acid and three boric acid compounds in reaction process, on the other hand, selected deleterious boron trifluoride for use.
Summary of the invention:
The invention belongs to the technical field of the organic boronic compound production preparation in fields such as being widely used in medicine, agricultural chemicals, material, bio-sensing detection, the simple and easy preparation technology of substituted alkyl phenylo boric acid is provided.Its main technical schemes is: traditional Grignard reagent preparation and two steps of low temperature nucleophilic substitution are combined into i.e. " one kettle way " preparation of a step, and product yield is higher, the reaction conditions gentleness, and the reaction times reduces by half, and quantity of solvent reduces by half; Aftertreatment is simple, has simplified production unit simultaneously, has reduced production cost.
The preparation method of alkyl substituted benzene boric acid of the present invention is:
1) tetrahydrofuran solution with alkyl bromobenzene, trialkylboron acid esters is added drop-wise in the reactor that fills magnesium chips, and temperature of reaction is 25-40 ℃, about reaction times 3h, makes alkylbenzene boric acid dialkyl solution.
2) reaction mixture with above-mentioned preparation is added to hydrolysis in the cold diluted mineral acid, extraction, and organic solvent is reclaimed in distillation.
3) add rare alkaline solution in the above-mentioned concentrated solution that makes, organic solvent is removed in aqueous vapor distillation, suction filtration, acidifying, crystallization, dry alkylbenzene boric acid.
Wherein the reaction in preferably trialkylboron acid esters raw material comprise trimethyl borate, triethyl borate, triisopropyl borate ester, tri-n-butyl borate, wherein be more preferably tri-n-butyl borate.Solvent comprises ethers preferably, as ether, tetrahydrofuran (THF) etc., wherein is more preferably tetrahydrofuran (THF).
The hydrolysis of the substituted benzene boric acid dialkyl compound that makes in the reaction 1 mineral acid preferably is hydrochloric acid or sulfuric acid.
Reaction process is schematically as follows:
Embodiment
In order further to understand the present invention, detail of the present invention is described with following example.
Embodiment:
2, the preparation of 6-dimethyl benzene boric acid
1) add the 2.92g magnesium chips in the 250ml four-hole round-bottomed flask, with 18.5g 2, the solution that 6-dimethyl bromobenzene, the positive butyl ester of 34.5g boric acid and 50mL tetrahydrofuran (THF) are formed splashes into flask under the nitrogen protection.The several minutes afterreaction begins, and solution temperature raises.Regulate rate of addition, make solution temperature maintain 20～30 ℃, about 1.5h drips off.Insulated and stirred 1h obtains 2 solution.
2) solution 2 is poured in the dilute hydrochloric acid of 100ml, stirs.Tell organic layer after leaving standstill, water layer extracted with diethyl ether (100ml * 3).Merge organic layer, decompression and solvent recovery.
3) concentrated solution is transferred pH=11～13 with diluted sodium hydroxide solution.Butanols etc. is removed in reduced steam distillation (40-50 ℃), filtered while hot, and filtrate is acidified to pH=2, separates out crystallization, cooling, suction filtration.Product is dried to constant weight 11.7g at 63 ℃, yield 78.9%, (detecting purity with high performance liquid phase is 98.0%, and traditional Grignard is consistent with the content purity of " one kettle way " of the present invention products obtained therefrom, sees Fig. 1, Fig. 2, Fig. 3).
Claims (8)
1. one kind " one kettle way " prepares the simple and easy production technique of alkyl substituted benzene boric acid.
The structural formula of alkyl substituted benzene boronic acid compounds is as follows:
2. alkyl substituted benzene boric acid as claimed in claim 1 is meant R
1Be alkyl R
2Be hydrogen or R
1And R
2All be alkyl, R
3Be substituted benzene boric acid such as alkoxyl group, hydrogen, alkyl.
3. the technology as claim 1 " one kettle way " preparation alkyl substituted benzene boric acid is: the mixing solutions of alkyl substituted phenyl-bromide and trialkylboron acid esters is added drop-wise in the reactor that fills magnesium chips, generates alkyl substituted benzene boric acid dialkyl; The hydrolysis of alkyl substituted benzene boric acid dialkyl adds the alkaline solution steam distillation or adds the alkaline solution extraction heat.
4. method as claimed in claim 3, it is characterized in that drips of solution with alkyl bromobenzene, trialkylboron acid esters is added to makes alkylbenzene boric acid dialkyl in the reactor that fills magnesium chips, but not at first make Grignard reagent by alkyl bromobenzene and magnesium chips, under low temperature, carry out nucleophilic substitution with the trialkylboron acid esters again.
5. method as claimed in claim 3, it is characterized in that the hydrolysis of alkylbenzene boric acid dialkyl after, add alkaline solution aqueous vapor distillation or add the alkaline solution extraction heat.
6. method as claimed in claim 3 is characterized in that temperature of reaction is controlled at 25 ℃-40 ℃.
7. method as claimed in claim 3 is characterized in that reaction solvent is an ether, comprises ether, tetrahydrofuran (THF) etc.
8. method as claimed in claim 3 is characterized in that used trialkylboron acid esters is trimethyl borate, triethyl borate, tributyl borate, boric acid isopropyl ester, the preferred boric acid tri-n-butyl.
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| Application Number | Priority Date | Filing Date | Title |
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| CN200910042485A CN101775029A (en) | 2009-01-13 | 2009-01-13 | Convenient synthesis method for alkyl substitution phenyloboricacid |
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| CN200910042485A CN101775029A (en) | 2009-01-13 | 2009-01-13 | Convenient synthesis method for alkyl substitution phenyloboricacid |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225881A (en) * | 2011-04-28 | 2011-10-26 | 西安近代化学研究所 | 9,9<,>-bisanthracene derivative and preparation method thereof |
| CN107224580A (en) * | 2016-03-25 | 2017-10-03 | 南京中硼联康医疗科技有限公司 | Application of the class a-amino acid boron trifluoride compound in boron neutron capture therapy |
| CN112028917A (en) * | 2020-10-10 | 2020-12-04 | 珠海奥博凯生物医药技术有限公司 | Preparation method of 3-aldehyde-4-methyl phenylboronic acid |
-
2009
- 2009-01-13 CN CN200910042485A patent/CN101775029A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225881A (en) * | 2011-04-28 | 2011-10-26 | 西安近代化学研究所 | 9,9<,>-bisanthracene derivative and preparation method thereof |
| CN102225881B (en) * | 2011-04-28 | 2014-12-10 | 西安近代化学研究所 | 9,9<,>-bisanthracene derivative and preparation method thereof |
| CN107224580A (en) * | 2016-03-25 | 2017-10-03 | 南京中硼联康医疗科技有限公司 | Application of the class a-amino acid boron trifluoride compound in boron neutron capture therapy |
| CN107224580B (en) * | 2016-03-25 | 2020-10-16 | 南京中硼联康医疗科技有限公司 | Application of alpha-amino acid-like boron trifluoride in boron neutron capture therapy |
| CN112028917A (en) * | 2020-10-10 | 2020-12-04 | 珠海奥博凯生物医药技术有限公司 | Preparation method of 3-aldehyde-4-methyl phenylboronic acid |
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Open date: 20100714 |