CN101757523A - Traditional Chinese medicine for treating iron-deficiency anemia - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating iron-deficiency anemia, belonging to the technical field of traditional Chinese medicines. The traditional Chinese medicine is prepared by using 9 Chinese medicinal herbs such as codonopsis pilosula, raidx astragali, Chinese angelica, and the like as raw materials and is prepared by the steps of: crushing 1/2 of the Chinese angelica into fine powder; mixing with bighead atractylodes rhizome, rhizoma atractylodis and curcuma zedoary and distilling with steam for extracting essential oil; mixing with the codonopsis pilosula, the raidx astragali and the left 1/2 of the Chinese angelica, extracting with alcohol, filtering, decompressing and concentrating filtrate into a thick paste; mixing with mrlberrt fruit, fruit of Chinese wolfberry and fructus ziziphi jujubae and adding water for decocting; filtering decoction, decompressing and concentrating filtrate into a thick paste; mixing the two thick pastes, uniformly stirring, drying into a dried paste, crushing into fine powder, adding the fine powder of the Chinese angelica and a proper amount of medicinal pharmaceutic adjuvants and uniformly mixing to prepare particles; drying, cooling, spraying essential oil of the bighead atractylodes rhizome and the like, uniformly mixing, and closing to obtain the traditional Chinese medicine. The granular formulation prepared by the invention can effectively promote the iron absorption of the human body and avoid the stimulation of the digestive tract, and has remarkable treatment effect on the iron-deficiency anemia.

Description

A kind of Chinese medicine for the treatment of iron deficiency anemia

Technical field

The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to a kind of Chinese medicine for the treatment of iron deficiency anemia.

Background technology

Iron deficiency anemia is common clinical, frequently-occurring disease, belong to categories such as Chinese medicine " sallow ", " general edema with yellowish tinge of the skin ", " deficient ", " asthenia ", it is to store the ferrum deficiency in the body, influence the synthetic institute of hemoglobin and cause a kind of microcytic hypochromic anemia, it be comprise all over the world in China's anemia modal a kind of.The primary disease sickness rate is very high, extend over the entire globe almost, no matter be city or rural area, child, adult or old age can take place per capita, Epidemiological study shows that the preschooler and the women of child-bearing age are two group of people at high risks of this disease, mainly is because growth promoter is required or physiology consumption increase causes due to the ferrum Deficiency of Intake.

At present, the treatment iron deficiency anemia, doctor trained in Western medicine medicine commonly used is an oral iron preparation:, ferrous carbonate ferrous as sulfur, 10% ferric ammonium citrate etc.Application sulfur is ferrous, causes gastrointestinal upset easily, heartburn sense, constipation or diarrhoea.Can cause acute poisoning, acute necrotizing enteritis when heavy dose of, and can increase absorbtivity, cause hepatic necrosis.Take ferric ammonium citrate, can dye tongue, tooth black.As dark intramuscular injection iron dextran, can cause local pain, medicinal liquid is spilled over to the subcutaneous skin dyeing that causes; Allergy is flush, dizziness, uncomfortable in chest, nauseating, vomiting, heating even anaphylactic shock then, cardiac arrest; Inject the excessive hemosiderosis that causes, involve liver, the heart, pancreas function, as use Iron Sorbitex, anaphylactic shock and dissociation appear in the patient who has.And Chinese medicine commonly used is decocts such as SIWU TANG, Radix Angelicae Sinensis decoction for tonifying blood, GUIPI TANG on the tcm clinical practice, and the shortcoming of these conventional Chinese medicines is that dosage is big, flavour of a drug heavy, mouthfeel is bad, is difficult to take for a long time, thereby therapeutic effect is slow.

Summary of the invention

The invention provides a kind of Chinese medicine for the treatment of iron deficiency anemia, be with Radix Codonopsis, the Radix Astragali, Radix Angelicae Sinensis etc. totally nine the flavor Chinese crude drugs be raw material, the granule that makes according to the common process step, can more effective promotion body to the absorption of ferrum, and avoided gastral stimulation, iron deficiency anemia is had notable therapeutic effect.

The present invention is achieved by the following technical solutions:

A kind of Chinese medicine for the treatment of iron deficiency anemia, it is that raw material is made by following parts by weight of Chinese traditional medicine material:

Radix Codonopsis 15-60 part Radix Astragali 20-70 part Radix Angelicae Sinensis 40-75 part

Rhizoma Atractylodis Macrocephalae 40-90 part Rhizoma Atractylodis 50-100 part Rhizoma Curcumae 20-80 part

Fructus Mori 30-90 part Fructus Lycii 10-40 part Fructus Jujubae 10-30 part

And the weight portion proportioning of described each Chinese crude drug raw material is:

60 parts of 45 parts of Radix Angelicae Sinensis of 45 parts of Radixs Astragali of Radix Codonopsis

50 parts of 75 parts of Rhizoma Curcumae of 65 parts of Rhizoma Atractylodis of the Rhizoma Atractylodis Macrocephalae

15 parts in 25 portions of Fructus Jujubaes of 60 parts of Fructus Lycii of Fructus Mori

Its preparation method comprises the steps:

(1) get Radix Angelicae Sinensis 1/2 and be ground into fine powder, standby;

(2) Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Curcumae are ground into coarse powder, mix, extract volatile oil with vapor distillation, the aqueous solution after the distillation filters, and is standby;

(3) Radix Codonopsis, the Radix Astragali and remaining 1/2 Radix Angelicae Sinensis mix, and add 60～80% alcohol reflux, filter (medicinal residues are standby), and merging filtrate, decompression recycling ethanol also is condensed into the thick paste that relative density is 1.31～1.35 (50～60 ℃), and is standby;

(4) Fructus Mori, Fructus Lycii, Fructus Jujubae mix with the alcohol extraction medicinal residues of step (3), decoct with water, and decocting liquid filters, the aqueous solution in filtrate and the step (2) after the distillation, and concentrating under reduced pressure becomes relative density to be the thick paste of 1.32～1.36 (70～80 ℃), and is standby;

Two thick pastes that (5) will make mix, and stir, and drying under reduced pressure becomes dried cream, is ground into fine powder, add Radix Angelicae Sinensis fine powder and suitable proper quantity of medicinal auxiliary material, make granule behind the mixing, and drying is put coldly, and spray adds volatile oil such as the above-mentioned Rhizoma Atractylodis Macrocephalae, and mixing is airtight, promptly.

For beneficial effect of the present invention better is described, we have carried out following clinical research:

1 data and method

1.1 case is selected

Selection is made a definite diagnosis and is in hospital and outpatient service iron deficiency anemia patient 65 examples with " hematopathy diagnosis and criterion of therapeutical effect ", and is divided into some groups by different crowd: adult group's (18 example), old group (9 example), postoperative group (5 example), anemia of pregnant woman's group (7 example), juvenile group (12 example) and child's group (14 example).

1.2 Therapeutic Method

According to preparation method of the present invention, adopt following main side to make granule: Radix Codonopsis 45g, Radix Astragali 45g, Radix Angelicae Sinensis 60g, Rhizoma Atractylodis Macrocephalae 65g, Rhizoma Atractylodis 75g, Rhizoma Curcumae 50g, Fructus Mori 60g, Fructus Lycii 25g, Fructus Jujubae 15g.The all oral granule solution of the present invention of all cases (with before adding an amount of hot dissolved in boiled water), each 1 bag, tid, be 4 weeks the course of treatment.Each patient is writing down symptom and sign respectively before and after the treatment and during the treatment, and projects such as the promoting the circulation of blood routine of going forward side by side, serum levels of iron content, total iron binding capacity detect.

1.3 curative effect judging standard

Recovery from illness: hemoglobin concentration (Hb) recovers normal, and clinical symptom disappearance, serum levels of iron content (ST), total iron binding capacity (TiBc) etc. recover normal;

Produce effects: clinical symptoms is clearly better, and anemia transfers slightly (improvement reaches more than 2 grades) to by severe;

Effectively: clinical symptoms takes a turn for the better, and the classification of anemia severity improves 1 grade;

Invalid: clinical symptoms and the classification of anemia severity do not have improvement.

Calculate as follows:

Obvious effective rate=(the routine number of fully recovering+produce effects example number)/total routine number * 100%;

Effective percentage=(the routine number of fully recovering+produce effects example number+effective routine number)/total routine number * 100%.

1.4 statistical method

All data are learned processing by statistics and are represented that with x ± s relatively with the x check, measurement data is checked with t between group.

2 results

2.1 clinical efficacy

After oral granule solution of the present invention treated for 4 weeks, 51 routine non-children organized among the patient, 17 examples of fully recovering (33.3%), produce effects 16 examples (31.4%), effective 12 examples (23.5%); Invalid 8 examples (15.7%), obvious effective rate are 64.7%, and total effective rate is 88.2%; 14 routine children organize among the patient, 8 examples of fully recovering (57.1%), and produce effects 2 examples (14.3%), effective 3 examples (21.4%), invalid 2 examples (14.3%), obvious effective rate is 71.4%, total effective rate is 85.7% (the results are shown in Table 1).It is similar that each organizes the patients clinical curative effect.

Respectively organize case curative effect comparative result after table 1 treatment

2.2 routine blood test detects

After oral granule solution of the present invention treated for 4 weeks, each was organized the every index of patient's routine blood test and all is significantly improved: before and after the treatment variation of Hb through one factor analysis of variance, F=286.2679, P=0.0000; Mean corpuscular volume (MCV) compares, t=8.6354, P=0.0000; Mean corpuscular hemoglobin (MCH) compares, t=25.4925, P=0.0000 (the results are shown in Table 2).

Respectively organize relatively (x ± s) of case routine blood test index before and after table 2 treatment

2.3SI and TiBc detects

After oral granule solution of the present invention treated for 4 weeks, each was organized patient SI and significantly raises, and TiBc then significantly reduces: before and after the treatment, its SI compares, t=21.2508, P=0.0000; TiBc compares, t=18.0563, P=0.0000 (the results are shown in Table 3).

Respectively organize relatively (x ± s) of case SI and TiBc before and after table 3 treatment

2.4 untoward reaction

Each group is not found obvious toxic-side effects, and general untoward reaction is slightly, the accidental mild nausea of a few patients, epigastric discomfort and just inferior increasing.Above-mentioned untoward reaction need not special disposal, and does not influence the continuation medication treatment.

3 sum up

This test shows that to 65 routine extended clinical observations of granule treatment iron deficiency anemia of the present invention it is 64.7% that non-child organizes obvious effective rate, and total effective rate is 88.2%; It is 71.4% that the child organizes obvious effective rate, and total effective rate is 85.7%.Credit is analysed by statistics, and curative effect does not have significant difference between each group, shows that granule of the present invention is similar to the different crowd curative effect of iron deficiency anemia.Its curative effect and patient's course of disease, age, sex do not have obvious relation, and the result who points out this medicine to be used for clinical trial is rigorous credible.Clinical research data also shows, granule of the present invention is to improving iron deficiency anemia patient clinical symptoms,, spiritlessness and weakness pale, edema, the vexed discomfort of gastral cavity, dizzy, ear as complexion and skin toot etc. better curative effect all arranged; In addition, other lab testings all are significantly improved as indexs such as MCV, MCH, Hb, SI, TiBc.

The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.

The specific embodiment

Embodiment 1:

Adopting following medical material is raw material:

Radix Codonopsis 45g Radix Astragali 45g Radix Angelicae Sinensis 60g

Rhizoma Atractylodis Macrocephalae 65g Rhizoma Atractylodis 75g Rhizoma Curcumae 50g

Fructus Mori 60g Fructus Lycii 25g Fructus Jujubae 15g

Its preparation method comprises the steps:

(1) get Radix Angelicae Sinensis 30g, be ground into fine powder, standby;

(2) with Rhizoma Atractylodis Macrocephalae 65g, Rhizoma Atractylodis 75g, Rhizoma Curcumae 50g, be ground into coarse powder, mix, extract volatile oil with vapor distillation, the aqueous solution after the distillation filters, and is standby;

(3) Radix Codonopsis 45g, Radix Astragali 45g and remaining 30g Radix Angelicae Sinensis mix, and add 70% alcohol reflux 3 times, and each 1 hour, filter (medicinal residues are standby), merging filtrate, decompression recycling ethanol also is condensed into the thick paste that relative density is 1.34 (50 ℃), and is standby;

(4) Fructus Mori 60g, Fructus Lycii 25g, Fructus Jujubae 15g mix with the alcohol extraction medicinal residues of step (3), decoct with water each 1 hour 4 times, decocting liquid filters, aqueous solution in filtrate and the step (2) after the distillation, concentrating under reduced pressure becomes relative density to be the thick paste of 1.34 (70 ℃), and is standby;

Two thick pastes that (5) will make mix, and stir, and drying under reduced pressure becomes dried cream, is ground into fine powder, add Radix Angelicae Sinensis fine powder, the about 25g of cane sugar powder and the about 86g of starch, make granule behind the mixing, and drying is put coldly, sprays volatile oil such as adding the above-mentioned Rhizoma Atractylodis Macrocephalae, and mixing is airtight, promptly.

Embodiment 2:

Adopting following medical material is raw material:

Radix Codonopsis 60g Radix Astragali 65g Radix Angelicae Sinensis 75g

Rhizoma Atractylodis Macrocephalae 90g Rhizoma Atractylodis 100g Rhizoma Curcumae 80g

Fructus Mori 80g Fructus Lycii 35g Fructus Jujubae 20g

Its preparation method comprises the steps:

(1) get Radix Angelicae Sinensis 37.5g, be ground into fine powder, standby;

(2) with Rhizoma Atractylodis Macrocephalae 90g, Rhizoma Atractylodis 100g, Rhizoma Curcumae 80g, be ground into coarse powder, mix, extract volatile oil with vapor distillation, the aqueous solution after the distillation filters, and is standby;

(3) Radix Codonopsis 60g, Radix Astragali 65g and remaining 37.5g Radix Angelicae Sinensis mix, and add 80% alcohol reflux 4 times, and each 1 hour, filter (medicinal residues are standby), merging filtrate, decompression recycling ethanol also is condensed into the thick paste that relative density is 1.32 (60 ℃), and is standby;

(4) Fructus Mori 80g, Fructus Lycii 35g, Fructus Jujubae 20g mix with the alcohol extraction medicinal residues of step (3), decoct with water each 1 hour 3 times, decocting liquid filters, aqueous solution in filtrate and the step (2) after the distillation, concentrating under reduced pressure becomes relative density to be the thick paste of 1.32 (80 ℃), and is standby;

Two thick pastes that (5) will make mix, and stir, and drying under reduced pressure becomes dried cream, is ground into fine powder, add Radix Angelicae Sinensis fine powder, the about 33g of cane sugar powder and the about 112g of starch, make granule behind the mixing, and drying is put coldly, sprays volatile oil such as adding the above-mentioned Rhizoma Atractylodis Macrocephalae, and mixing is airtight, promptly.

Embodiment 3:

Adopting following medical material is raw material:

Radix Codonopsis 18g Radix Astragali 22g Radix Angelicae Sinensis 45g

Rhizoma Atractylodis Macrocephalae 40g Rhizoma Atractylodis 50g Rhizoma Curcumae 20g

Fructus Mori 30g Fructus Lycii 10g Fructus Jujubae 10g

Its preparation method comprises the steps:

(1) get Radix Angelicae Sinensis 22.5g, be ground into fine powder, standby;

(2) with Rhizoma Atractylodis Macrocephalae 40g, Rhizoma Atractylodis 50g, Rhizoma Curcumae 20g, be ground into coarse powder, mix, extract volatile oil with vapor distillation, the aqueous solution after the distillation filters, and is standby;

(3) Radix Codonopsis 18g, Radix Astragali 22g and remaining 22.5g Radix Angelicae Sinensis mix, and add 60% alcohol reflux, filter (medicinal residues are standby), and merging filtrate, decompression recycling ethanol also is condensed into the thick paste that relative density is 1.35 (55 ℃), and is standby;

(4) Fructus Mori 30g, Fructus Lycii 10g, Fructus Jujubae 10g mix with the alcohol extraction medicinal residues of step (3), decoct with water, and decocting liquid filters, the aqueous solution in filtrate and the step (2) after the distillation, and concentrating under reduced pressure becomes relative density to be the thick paste of 1.35 (75 ℃), and is standby;

Two thick pastes that (5) will make mix, and stir, and drying under reduced pressure becomes dried cream, is ground into fine powder, add Radix Angelicae Sinensis fine powder, the about 12g of cane sugar powder and the about 65g of starch, make granule behind the mixing, and drying is put coldly, sprays volatile oil such as adding the above-mentioned Rhizoma Atractylodis Macrocephalae, and mixing is airtight, promptly.

Claims (3)

1. Chinese medicine for the treatment of iron deficiency anemia is characterized in that it is that raw material is made by following parts by weight of Chinese traditional medicine material:

Radix Codonopsis 15-60 part Radix Astragali 20-70 part Radix Angelicae Sinensis 40-75 part

Rhizoma Atractylodis Macrocephalae 40-90 part Rhizoma Atractylodis 50-100 part Rhizoma Curcumae 20-80 part

Fructus Mori 30-90 part Fructus Lycii 10-40 part Fructus Jujubae 10-30 part.

2. a kind of Chinese medicine for the treatment of iron deficiency anemia according to claim 1, wherein the weight portion proportioning of each Chinese crude drug raw material is:

60 parts of 45 parts of Radix Angelicae Sinensis of 45 parts of Radixs Astragali of Radix Codonopsis

50 parts of 75 parts of Rhizoma Curcumae of 65 parts of Rhizoma Atractylodis of the Rhizoma Atractylodis Macrocephalae

15 parts in 25 portions of Fructus Jujubaes of 60 parts of Fructus Lycii of Fructus Mori.

3. according to each described a kind of Chinese medicine for the treatment of iron deficiency anemia of claim 1-2, its preparation method comprises the steps:

(1) get Radix Angelicae Sinensis 1/2 and be ground into fine powder, standby;

(2) Rhizoma Atractylodis Macrocephalae, Rhizoma Atractylodis, Rhizoma Curcumae are ground into coarse powder, mix, extract volatile oil with vapor distillation, the aqueous solution after the distillation filters, and is standby;

(3) Radix Codonopsis, the Radix Astragali and remaining 1/2 Radix Angelicae Sinensis mix, and add 60～80% alcohol reflux, filter (medicinal residues are standby), and merging filtrate, decompression recycling ethanol also is condensed into the thick paste that relative density is 1.31～1.35 (50～60 ℃), and is standby;

(4) Fructus Mori, Fructus Lycii, Fructus Jujubae mix with the alcohol extraction medicinal residues of step (3), decoct with water, and decocting liquid filters, the aqueous solution in filtrate and the step (2) after the distillation, and concentrating under reduced pressure becomes relative density to be the thick paste of 1.32～1.36 (70～80 ℃), and is standby;

Two thick pastes that (5) will make mix, and stir, and drying under reduced pressure becomes dried cream, is ground into fine powder, add Radix Angelicae Sinensis fine powder and suitable proper quantity of medicinal auxiliary material, make granule behind the mixing, and drying is put coldly, and spray adds volatile oil such as the above-mentioned Rhizoma Atractylodis Macrocephalae, and mixing is airtight, promptly.