CN101744905B - Applications of Chinese medicinal composition in preparation of medicament for treating pulmonary heart disease - Google Patents
Applications of Chinese medicinal composition in preparation of medicament for treating pulmonary heart disease Download PDFInfo
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Abstract
The invention discloses applications of a Chinese medicinal composition to prepration of a medicament for treating pulmonary heart disease. The Chinese medicinal composition of the invention comprises ginseng, sanguisuge, centipede, scorpion, ground beeltle, cicada slough, red paeony root, borneol and the like, and has effects of replenishing qi, activating blood, dissipating blood stasis and dredging collaterals. The clinical test shows that the Chinese medicinal composition of the invention can effectively treat pulmonary heart disease, and no untoward effects are found.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, the present invention relates to the application of a kind of Chinese medicine composition in preparation treatment pulmonary heart disease medicine, belong to the Chinese medicine application.
Background technology
Pulmonary heart disease is called for short pulmonary heart disease, is mainly due to acute pulmonary embolism, pulmonary vascular resistance is sharply increased, and cause the acute expansion of right ventricle and exhaustion.Emergency pulmonary heart disease by the course of disease can be divided into acute cor pulmonale and chronic pulmonary heart disease, chronic person is comparatively common, it is mainly the pulmonary vascular resistance increase that causes due to chronic pulmonary, thoracopathy or lung vascular lesion, the right ventricle load is increased the weight of, right ventricular hypertrophy causes each heart disease of right heart failure at last.Its common cause of disease mainly contains chronic bronchitis, the concurrent chronic obstructive emphysema of bronchial asthma, accounts for 80-90%, is secondly bronchiectasis, pulmonary tuberculosis, pneumosilicosis, chronic pulmonary interstitial fibrosis, chest deformity, pachynsis pleurae etc.This disease disease is slow, and sings and symptoms progressively occurs, and early stage respiratory and circulatory function still can be compensatory, but heart failure and respiratory failure occur to late period.
Clinically, the pulmonary heart disease course advancement is slow, can be divided into compensatory with lose compensatory two stages: 1, the patient has chronic cough, expectoration or asthma history the functional compensation phase, weak, dyspnea progressively occurs.2, the lung tissue infringement of compensatory phase of function mistake seriously causes anoxia, carbon dioxide retention, can cause breathing and (or) heart failure: the early stage main manifestations of (1) respiratory failure anoxia is cyanosis, cardiopalmus and uncomfortable in chest etc.; hypoxemia and hypercapnia occur when pathological changes further develops, various spiritual neurological disorder symptoms can occur; Therefore (2) heart failure mostly occurs after acute respiratory infection, often is associated with respiratory failure, and the patient asthma, cardiopalmus, oliguria, cyanosis occur and increases the weight of, the right heart failure symptoms such as upper abdomen distending pain, inappetence, the even vomiting of feeling sick.
The Drug therapy of pulmonary heart disease mainly comprises single dose medication and drug combination, and the single dose medication is nifedipine commonly used, captopril, phentolamine, Ahylysantinfarctase-II, magnesia mixture and DOPA oxyphenisatin peace etc. mainly; Drug combination comprises that mainly nifedipine adds Xinnao Shutong, and phentolamine adds dopamine, and phentolamine adds aminophylline, and phentolamine adds heparin, and dopamine adds Anisodamine, and dopamine adds magnesium sulfate etc.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 and No. 200410048292.2 patent, quotes in full the content of this two patent documents record at this.The application of unexposed this Chinese medicine composition of above-mentioned two patents in preparation treatment pulmonary heart disease medicine.
Summary of the invention
The object of the invention is to provide the application of a kind of Chinese medicine composition in preparation treatment pulmonary heart disease medicine;
Preferably, the present invention also provides the application of this Chinese medicine composition in preparation treatment chronic cardiopulmonary disease medicine.
The present invention uses described Chinese medicine composition and contains Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, five kinds of insect medicines of Periostracum Cicadae, add Radix Ginseng, Borneolum Syntheticum, Radix Paeoniae Rubra etc., can reduce blood viscosity, effectively slow down the links that pulmonary heart disease forms, reduce pulmonary artery pressure, improve pulmonary ventilation and cardiac function, can effectively treat pulmonary heart disease.
Described Chinese medicine composition is made by the crude drug of following weight portion:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by the crude drug of following weight portion:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophaga 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpio 7 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophaga 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpio 9 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophaga 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpio 3 Periostracum Cicadae 7 Scolopendra 1 Borneolum Syntheticum 5 Semen Ziziphi Spinosaes (stir-fry) 5;
The active component of above-mentioned Chinese medicine composition is comprised of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after with ethanol extraction after concentrated;
The water extracted immersing paste that is condensed into after water extraction liquid after Lignum Dalbergiae Odoriferae after e extraction composition c and water extraction liquid, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extraction liquid filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, mixing.
In Chinese medicine composition of the present invention, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
It is capsule, tablet, granule, powder, oral liquid or pill that the present invention uses the preparation formulation that also discloses above-mentioned Chinese medicine composition.
For above-mentioned dosage form can be realized, need to add the acceptable adjuvant of pharmacy when these dosage forms of preparation, such as: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, acetic acid chloroethene are decided, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The present invention uses the capsule of described Chinese medicine composition and preferably makes by following preparation method: the five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to nothing alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing incapsulates, and get final product.
Perhaps, the present invention uses described capsule and preferably makes by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water again, after water extraction liquid filters, and one-tenth extractum to be concentrated; Radix Ginseng with ethanol extraction after, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, water extraction liquid filter with all water extraction liquid mixings after be condensed into the water extracted immersing paste;
D) preparation process:
Adding the superfine powder flour in Fluidbedgranulatingdrier, then with step c) gained extracts extractum and sprays into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule after mixing.
Perhaps, the present invention uses described capsule and preferably makes by following preparation method:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water again, after water extraction liquid filters, and one-tenth extractum to be concentrated; Radix Ginseng with ethanol extraction after, then use water extraction, alcohol extract is condensed into alcohol-extracted extract after reclaiming ethanol, water extraction liquid filter with all water extraction liquid mixings after be condensed into the water extracted immersing paste, the extractum Direct spraying is dried to spray powder;
D) preparation process:
With superfine powder flour and step c) be added in Fluidbedgranulatingdrier together with the gained spray drying powder, then spray the solvent granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule after mixing.
The present invention uses the consumption of described Chinese medicine composition, is converted to the weight of raw medicinal material, is each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 gram, takes every day three times.
The specific embodiment
Embodiment 1:
A) the crude drug formula is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary again, and each 3 hours, merge water extraction liquid, after filtration, one-tenth extractum to be concentrated; Radix Ginseng is with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to distinguishing the flavor of without alcohol, use again water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.1 alcohol-extracted extract, water extraction liquid filter with above-mentioned all water extraction liquid mixings after be concentrated into 60 ℃ to measure relative densities be 0.9～1.1 clear paste, standby;
D) preparation process:
Adding the superfine powder flour in Fluidbedgranulatingdrier, then with step c) gained extracts extractum and sprays into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules after mixing.
The consumption of medicine of the present invention for each 2-4 grain, is taken three times every day.
Embodiment 2
A) the crude drug formula is:
Radix Ginseng 66g Hirudo 52.8g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 59.4g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 70-90 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary again, and each 3 hours, merge water extraction liquid, after filtration, one-tenth extractum to be concentrated; Radix Ginseng is with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to distinguishing the flavor of without alcohol, use again water extraction, alcohol extract is condensed into relative density and is determined as 1.0～1.05 alcohol-extracted extracts at 60 ℃, water extraction liquid filter with above-mentioned all water extraction liquid mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
Adding the superfine powder flour in Fluidbedgranulatingdrier, then with step c) gained extracts extractum and sprays into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, preparation process is pressed into 1000 routinely.
The consumption of medicine of the present invention for each 2-4 sheet, is taken three times every day.
Embodiment 3: the preparation of pill
A) the crude drug formula is:
Radix Ginseng 39.6g Hirudo 66g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 46.2g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes medicated powder mean diameter 10-20 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary again, and each 3 hours, merge water extraction liquid, after filtration, one-tenth extractum to be concentrated; Radix Ginseng is with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to distinguishing the flavor of without alcohol, use again water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.0 alcohol-extracted extract, water extraction liquid filter with above-mentioned all water extraction liquid mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
Preparation process, make 1000 pills routinely.
The consumption of medicine of the present invention for each 2-4 grain, is taken three times every day.
Experimental example:
For illustrating the curative effect of traditional Chinese medicine composition for treating pulmonary heart disease of the present invention, use the capsule (hereinafter referred to as medicine of the present invention) that makes by above-described embodiment 1 method to carry out following test proving its curative effect, but it can not consist of any restriction to scope of the present invention.
1 data and method
1.1 physical data patient is Hebei Yi Ling hospital outpatient patient, totally 70 examples.70 routine patients are divided into treatment group and matched group at random, and two groups of clinical data difference nonsignificances have comparability.Specifically see Table 1.
Table 1 liang group patient physical data is (example) relatively
1.2 inclusion criteria
(1) meet the Diagnosis of Chronic Cor standard; (2) according to medical history, chest x-ray is taken the photograph sheet, and electrocardiogram all meets pulmonary heart disease diagnosis and cardiac functional grading diagnosis; (3) hemorrhage except.
1.3 method
Two groups of all treatments routinely, treatment group patient adds medicine of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd's production) 2-4 grain, every day 3 times, takes altogether half a year; The matched group patient carries out conventional therapy.Treat the cardiac functional grading that moves ahead, Color Sonography detects, and further consultation was 1 time in later every 6 months, totally 2 times.Record physical active situation, compliance investigation and side effect, check Color Sonography when finish the course for the treatment of.
1.4 the dirty ejection fraction of monitoring project Color Sonography thought-read (EF).
1.5 statistical method
Measurement data represents with X ± S, and enumeration data X ± S after to number conversion represents, relatively adopt the t check between different time points, group, enumeration data adopts X
2Check, P＜0.05 is the difference significance.
2 results
2.1 two groups of patient EF compare, treatment group and matched group are compared before each group is treated rear EF and this group is treated, and p＜0.05 has significant difference; Compare after EF and treatment of control group after treatment group treatment, p＜0.05 has significant difference.Specifically see Table 2.
The variation of EF before and after 2 groups of patient treatments of table 2 (X ± S)
Annotate: relatively front with treatment,
*P＜0.05; With comparison after treatment of control group,
*P＜0.05.
2.2 untoward reaction
Treatment group has 5 examples (accounting for 14.3%) period in a medicine that epigastric discomfort, acid regurgitation and mild nausea are arranged, and changes after meal drug administration symptom disappearance at once, without skin, mucosa hemorrhage, without liver, renal dysfunction.
3 conclusions
In sum, add on the conventional therapy basis and use Drug therapy of the present invention, can improve patient's right ventricular ejection fraction, obviously improve cardiac function, improve the quality of living, proved invention medicine can effectively be treated chronic cardiopulmonary disease, and without obvious adverse reaction.
Claims (1)
1. the application in the medicine of Chinese medicine composition raising right ventricular ejection fraction in preparation treatment pulmonary heart disease, described Chinese medicine composition prepares by the following method:
A) the crude drug formula is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (processed) 13.2g Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (parched) 33g;
B) pulverizing medicinal materials technique:
With Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae after cleaning, washing processing and the Olibanum (processed) after cleaning the process of preparing Chinese medicine by prescription batching, pulverized by pulverizer, more than the medicated powder fineness reaches 80 orders; Medicated powder after coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; , prepare burden after the cleaning, drying sterilization wait the medical material of pulverizing;
C) extract concentrated and drying process:
Use water extraction after the first extracting in water volatile oil of Lignum Dalbergiae Odoriferae and Lignum Santali Albi, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary again, and each 3 hours, merge water extraction liquid, after filtration, one-tenth extractum to be concentrated; Radix Ginseng is with appropriate 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to distinguishing the flavor of without alcohol, use again water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.1 alcohol-extracted extract, water extraction liquid filter with above-mentioned all water extraction liquid mixings after be concentrated into 60 ℃ to measure relative densities be 0.9～1.1 clear paste, standby;
D) preparation process:
Adding the superfine powder flour in Fluidbedgranulatingdrier, then with step c) gained extracts extractum and sprays into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules after mixing.
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