CN101713740A - Method for spectrophotometry measuring boron content in BNCT medicament in biological sample - Google Patents
Method for spectrophotometry measuring boron content in BNCT medicament in biological sample Download PDFInfo
- Publication number
- CN101713740A CN101713740A CN200910215729A CN200910215729A CN101713740A CN 101713740 A CN101713740 A CN 101713740A CN 200910215729 A CN200910215729 A CN 200910215729A CN 200910215729 A CN200910215729 A CN 200910215729A CN 101713740 A CN101713740 A CN 101713740A
- Authority
- CN
- China
- Prior art keywords
- biological sample
- boron content
- solution
- bnct
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 229910052796 boron Inorganic materials 0.000 title claims abstract description 39
- 239000012472 biological sample Substances 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 27
- 239000003814 drug Substances 0.000 title claims abstract description 13
- 238000002798 spectrophotometry method Methods 0.000 title claims abstract description 11
- 238000005259 measurement Methods 0.000 claims abstract description 13
- 238000001514 detection method Methods 0.000 claims abstract description 4
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 14
- 239000000523 sample Substances 0.000 claims description 12
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 10
- 238000002835 absorbance Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- OZZOVSQSDIWNIP-UHFFFAOYSA-N acetic acid;azane Chemical compound [NH4+].[NH4+].CC([O-])=O.CC([O-])=O OZZOVSQSDIWNIP-UHFFFAOYSA-N 0.000 claims description 9
- 238000013016 damping Methods 0.000 claims description 8
- 239000012530 fluid Substances 0.000 claims description 8
- 239000008280 blood Substances 0.000 claims description 7
- 210000004369 blood Anatomy 0.000 claims description 7
- 230000029087 digestion Effects 0.000 claims description 4
- 238000012360 testing method Methods 0.000 abstract description 7
- 238000004458 analytical method Methods 0.000 abstract description 6
- 230000035945 sensitivity Effects 0.000 abstract description 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000002133 sample digestion Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 28
- 238000002474 experimental method Methods 0.000 description 9
- 239000003153 chemical reaction reagent Substances 0.000 description 8
- 239000004743 Polypropylene Substances 0.000 description 7
- -1 polypropylene Polymers 0.000 description 7
- 229920001155 polypropylene Polymers 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 238000005303 weighing Methods 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 239000010453 quartz Substances 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- 240000002853 Nelumbo nucifera Species 0.000 description 3
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 3
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000011580 nude mouse model Methods 0.000 description 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 2
- 239000005695 Ammonium acetate Substances 0.000 description 2
- 208000032612 Glial tumor Diseases 0.000 description 2
- 206010018338 Glioma Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229960000583 acetic acid Drugs 0.000 description 2
- 229940043376 ammonium acetate Drugs 0.000 description 2
- 235000019257 ammonium acetate Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000000559 atomic spectroscopy Methods 0.000 description 2
- 238000004166 bioassay Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 229940109262 curcumin Drugs 0.000 description 2
- 235000012754 curcumin Nutrition 0.000 description 2
- 239000004148 curcumin Substances 0.000 description 2
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 2
- 238000002848 electrochemical method Methods 0.000 description 2
- 239000012362 glacial acetic acid Substances 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 239000003182 parenteral nutrition solution Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 241000581650 Ivesia Species 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- LBDSXVIYZYSRII-IGMARMGPSA-N alpha-particle Chemical compound [4He+2] LBDSXVIYZYSRII-IGMARMGPSA-N 0.000 description 1
- PYKYMHQGRFAEBM-UHFFFAOYSA-N anthraquinone Natural products CCC(=O)c1c(O)c2C(=O)C3C(C=CC=C3O)C(=O)c2cc1CC(=O)OC PYKYMHQGRFAEBM-UHFFFAOYSA-N 0.000 description 1
- 150000004056 anthraquinones Chemical class 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 208000024055 brain glioblastoma Diseases 0.000 description 1
- 201000011609 brain glioblastoma multiforme Diseases 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000012916 chromogenic reagent Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Abstract
Description
Claims (3)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910215729XA CN101713740B (en) | 2009-12-31 | 2009-12-31 | Method for spectrophotometry measuring boron content in BNCT medicament in biological sample |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910215729XA CN101713740B (en) | 2009-12-31 | 2009-12-31 | Method for spectrophotometry measuring boron content in BNCT medicament in biological sample |
Publications (2)
Publication Number | Publication Date |
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CN101713740A true CN101713740A (en) | 2010-05-26 |
CN101713740B CN101713740B (en) | 2012-05-02 |
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CN200910215729XA Active CN101713740B (en) | 2009-12-31 | 2009-12-31 | Method for spectrophotometry measuring boron content in BNCT medicament in biological sample |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507465A (en) * | 2011-10-17 | 2012-06-20 | 攀钢集团江油长城特殊钢有限公司 | Novel turmeric direct photometry for determining boron content in steel |
CN103185715A (en) * | 2011-12-30 | 2013-07-03 | 北京有色金属研究总院 | Analytical method of ferroporphyrin in ore biological leaching liquid |
CN103604801A (en) * | 2013-10-29 | 2014-02-26 | 中国科学院东北地理与农业生态研究所 | Method for measuring boron content of low-grade boron ore by inductively coupled plasma atomic emission spectrometer |
CN104297234A (en) * | 2014-10-11 | 2015-01-21 | 北京华益精点生物技术有限公司 | Preparation methods of color developing agent and test paper for testing boric acid and borax |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3768442B2 (en) * | 2001-12-28 | 2006-04-19 | オルガノ株式会社 | Analytical sample preparation method and element quantification method |
SE528407C2 (en) * | 2005-08-19 | 2006-11-07 | Hammercap Ab | Boron compounds useful at BNCT |
CN2840019Y (en) * | 2005-10-31 | 2006-11-22 | 白莉 | Boron colorimetric estimation cylinder |
CN100487426C (en) * | 2005-10-31 | 2009-05-13 | 白莉 | Boron determination solution and colorimetric determination tube therefor |
-
2009
- 2009-12-31 CN CN200910215729XA patent/CN101713740B/en active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102507465A (en) * | 2011-10-17 | 2012-06-20 | 攀钢集团江油长城特殊钢有限公司 | Novel turmeric direct photometry for determining boron content in steel |
CN103185715A (en) * | 2011-12-30 | 2013-07-03 | 北京有色金属研究总院 | Analytical method of ferroporphyrin in ore biological leaching liquid |
CN103604801A (en) * | 2013-10-29 | 2014-02-26 | 中国科学院东北地理与农业生态研究所 | Method for measuring boron content of low-grade boron ore by inductively coupled plasma atomic emission spectrometer |
CN104297234A (en) * | 2014-10-11 | 2015-01-21 | 北京华益精点生物技术有限公司 | Preparation methods of color developing agent and test paper for testing boric acid and borax |
Also Published As
Publication number | Publication date |
---|---|
CN101713740B (en) | 2012-05-02 |
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Legal Events
Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C53 | Correction of patent of invention or patent application | ||
CB03 | Change of inventor or designer information |
Inventor after: Luo Zhifu Inventor after: Yang Tiansheng Inventor after: Li Fenglin Inventor after: Deng Xinrong Inventor after: Fan Caiyun Inventor after: Liu Zihua Inventor before: Li Fenglin Inventor before: Deng Xinrong Inventor before: Fan Caiyun Inventor before: Liu Zihua Inventor before: Luo Zhifu |
|
COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LI FENGLIN DENG XINRONG FAN CAIYUN LIU ZIHUA LUO ZHIFU TO: LUO ZHIFU YANG TIANSHENG LI FENGLIN DENG XINRONG FAN CAIYUN LIU ZIHUA |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant |