CN101700324A - Method for preparing drug for curing type II diabetes mellitus - Google Patents

Abstract

The invention discloses a method for preparing drug for curing type II diabetes mellitus, and the prescription thereof takes twelve foods of propolis, pueraria radix, grapes, peaches, soybeans, epimedium, rhizoma coptidis, pseudo-ginseng, liqusticum wallichii, whiteflower leadword root, crotalaria mucronata and bitter herbs and Chinese medicinal herb as raw materials. The above raw materials are subjected to the steps of soaking, wall-broken cryogenic grinding, extracting, chromatography, concentration, drying and the like to obtain the required drug components, and are recomposed and prepared into medicament, tablets and capsules. The invention starts from changing physical quality of diabetes mellitus patients, regulates and enhances tricarboxylicacid cycle to adjust sugar content in or out of cells, enhances cell in/out sugar content for rapid sampling pump regulation, removes antagonism of cells to insulin so as to render information and instruction of pancreas cell regulation and increasing secrete to cure diabetes mellitus, has good prevention effect, especially for prevention in advance by early administration for people with diabetes mellitus family history.

Description

A kind of preparation method for the treatment of the type medicine

Technical field

The invention belongs to the field of Chinese medicines, specifically a kind of preparation method for the treatment of the type ii diabetes medicine.

Background technology

Diabetes (diabetes) are to act on body by inherited genetic factors, immunologic function disorder, infected by microbes and toxin thereof, free radical toxin, Nervous and Mental Factors or the like various virulence factors to cause hypoinsulinism, insulin resistant (Insulin Resistance, and a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi IR) etc., be main feature clinically with the hyperglycemia, performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. " three-many-one-little " symptom.

Diabetes are divided type i diabetes and type ii diabetes.In diabetics, the shared ratio of type ii diabetes is about 95%.During type ii diabetes is more common in, the old people, its secretion of insulin amount is not low, even also higher, it is responsive inadequately to insulin that clinical manifestation is a body, promptly insulin resistant (InsulinResistance, IR).Diabetes can cause infection, heart change, cerebrovascular disease, renal failure, lose the sight of both eyes, lower limb gangrene etc. and become deadly major cause of morbidity.Be the multiple season of the concurrent hyperosmolality syndrome of sensile diabetic patient summer, because this sick case fatality rate is higher, can reach about 40%, men and women's incidence rate is similar, quite a few patient can not have clear and definite diabetic history before onset, or only be slight type 2 diabetes mellitus, so should cause patient and medical personnel's great attention.

China the earliest the medical book Plain Questions of Huangdi's Internal Classic and Miraculous Pivot in just put down in writing " diabetes " this name of disease.The piece of writing of quenching one's thirst of Han dynasty well-known doctor's Zhang Zhongjing " Medical Treasures of the Golden Chamber " is also on the books to " more than three " symptom.The first years of a historical period Tang Dynasty, the famous Zhen Liyan of doctor family of China points out that at first diabetes patient's urine is sweet.The doctor who confirms the earliest in the world and treat diabetes is Tang Dynasty in China well-known doctor Wang Tao.Wang Tao suffers from unbearably thirsty according to his father, the drink amount heightens, many on one's body furuncle, and the urine fruity, and according to pointing out in Zhen Liyan " bar the is tested at all times " book: the patient that quenches one's thirst urine is sweet like bran flakes, and father's urine so he tastes with one's own mouth is to confirm.So formulated therapeutic scheme at diabetes, be aided with the adjustment diet, make his father's state of an illness obtain rehabilitation, he has write into " medical secrets of official " book to these experiences.

Physician of all times is in continuous exploration, created the active drug of a large amount of treatment diabetes, most medicines all are to adopt the method that reduces (control) blood glucose, and the improvement of patient's whole body functional status obviously acts on, disease relapse after the drug withdrawal produces the phenomenon of " curing the symptoms, not the disease ".Some medicines also are easy to generate drug resistance, and patient just can keep curative effect using certain medicine article kind of just must changing dressings after reaching certain hour.

Summary of the invention

The present invention is single for the medicine composition that solves the treatment type ii diabetes that exists in the prior art, and problems such as weak effect provide a kind of preparation method for the treatment of the type ii diabetes medicine.

The medicine of treatment type ii diabetes of the present invention forms by clinic tests and repeated verification configuration for many years, meets the theory of Chinese medicine.Prescription is to be raw material with food, Chinese herbal medicine, through immersion, breaking cellular wall freezing and pulverizing and quench and get, concentrate, drying etc. obtained required pharmaceutical compositions, makes medicament, tablet, capsule again after composite.

As everyone knows, the patient that blood glucose is high can not prove himself not excreting insulin, not necessarily blood glucose is not high for patient that equally can the excreting insulin function, due to the high just insulin secretion level of blood glucose is low, if but insulin injection prematurely, the human pancreas will mend into stopping secretion of insulin because of external insulin, causes diabetics to rely on insulin throughout one's life.The inventor is through research for many years, sugar content height in the high just blood of so-called blood glucose, and endoglobar sugared content is not high, that is to say that cell wall has stoped sugared absorption to cause blood sugar increasing, but human body is by hemocyte sugar to be absorbed to send into liver then to the absorption of sugar, blood flow is when pancreas, pancreas also is to carry out secretion of insulin according to the information of the sugar content in the hemocyte, insulin and blood are mixed into liver, sugar is absorbed the nutrition that becomes human body by liver, therefore can illustrate, the secretory volume of human insulin depends on endoglobar sugar content, hemocyte depends on osmotic pressure inside and outside the cell wall to the absorption of blood glucose, and how regulating the inside and outside osmotic pressure of cell wall is the key of treatment prevent diabetes.

Medicine of the present invention is made up of the drug extract of following weight portion proportioning:

Herba Epimedii 1-7 part, propolis 2-12 part, Radix Puerariae 2-5 part, Fructus Vitis viniferae 0.1-2 part, peach 0.1-2 part,

Radix Plumbaginis Zeylanicae 1-4 part, Semen sojae atricolor 8-15 part, Rhizoma Coptidis 2-8 part, Radix Notoginseng 0.1-3 part, Rhizoma Chuanxiong 0.1-3 part,

Herba crotalariae mucronatae 0.1-5 part, Herba Sonchi Oleracei 2-12 part;

Preparation method:

The Main Ingredients and Appearance preparation method of extract:

The preparation method of propolis extract: by formula proportion freezing 24 hours of propolis → be crushed to 30-100 mesh sieve → stirring is added in the boiling water to remove impurity → precipitate freezing 24 hours → to pulverize → be dissolved in 70% ethanol → filtrations and add ethanol to 85% and dissolve 24 hours → filtering and concentrating → drying → finished product.

The preparation method of Radix Puerariae extract: Radix Puerariae stripping and slicing → place 2-4 is doubly measured alcohol reflux 2 times → extract → be concentrated into the neutral lead acetate of concentration of alcohol 15-20% → add by formula proportion and leave standstill filtration → filtration filtrate and add Lead monosubacetate and leave standstill filtration → filtration and leach thing in 70% ethanol lead → filtering precipitate → place 1 time → crystal of 95% ethyl alcohol recrystallization to be drying to obtain.

The peach preparation method of extract: ripe fruit 5 → 10 times of water gagings of squeezing the juice → add boil → put cold filtration → adding lime water PH12 → sedimentation and filtration → precipitate and add suitable quantity of water dissolving back and add neutral lead acetate and leave standstill filtrations → filtrate adding Lead monosubacetate and leave standstill filtration → filter liquor and add ethanol to 70% filtration → filtrate and be concentrated into 1/3 volume and add ethanol to 95% → filter → leach thing to be drying to obtain.

2, the preparation of other composition extract extract according to a conventional method, dry, pulverize promptly.

3, to press formula proportion composite for each drug extract, can be made into tablet or capsule after mix homogeneously, the drying.

The pharmacological property of each medicine of the present invention is as follows:

Propolis

[meridian distribution of property and flavor] is hot, warm.

[function cures mainly] softens keratinized tissue, pain relieving.Be used for clavus, callus, verruca vulgaris.Propolis has broad spectrum antibacterial function, can strengthen some antibiotic effect, and propolis has the effect of anti-inflammatory and antalgic, propolis has the regenerated effect of the histiocyte of promotion, and propolis has therapeutical effect to gastric ulcer, and propolis has good antitumaous effect, propolis can triglyceride reducing, again can cholesterol reducing.

Radix Puerariae:

[nature and flavor] are cool in nature, sweet in the mouth, suffering.

[function cures mainly] induced sweat and brought down a fever, and promotes the production of body fluid rash, yang invigorating antidiarrheal.Be used for fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels.

Fructus Vitis viniferae:

[meridian distribution of property and flavor] property is flat, sweet in the mouth is sour, goes into lung, spleen, kidney channel;

[function cures mainly] have fill blood, the effect of liver and kidney tonifying, born fluid, bone and muscle strengthening, cough-relieving relieving restlessness, benefiting vital QI and blood, tonneau urine; Cure mainly diseases such as deficient qi and blood, cough due to deficiency of the lung, palpitation and night sweat, rheumatic arthralgia, stranguria, edema, also can be used for the auxiliary treatment of diseases such as deficiency of the spleen causing weakness of QI, shortness of breath and fatigue, edema, dysuria.

Peach:

Stomach, large intestine channel are returned in the sweet acid of [meridian distribution of property and flavor] peach meat flavour, warm in nature;

[function cures mainly] has yin nourishing, promotes the production of body fluid, moisturizes the effect of invigorating blood circulation; It is thirsty to cure mainly summer, constipation, and dysmenorrhea, asthenia is breathed with cough, hernia pain, seminal emission, spontaneous perspiration, diseases such as night sweat.

Semen sojae atricolor:

[meridian distribution of property and flavor] sweet in the mouth, property are put down, and go into spleen, large intestine channel,

[function cures mainly] can kill Aconitum carmichjaelii Debx., Radix Aconiti Lateralis Preparata poison; Have the spleen invigorating alleviating distention in middle-JIAO, moisturize the effect of the water that disappears, heat-clearing and toxic substances removing, QI invigorating; Cure mainly infantile malnutrition dysentery, abdominal distention and win thin, gestosis, sore and toxic, traumatic hemorrhage etc.Semen Glycines can also anti-inflammation, and is effective to pharyngitis, conjunctivitis, stomatitis, bacillary dysentery, enteritis.

Herba Epimedii:

[meridian distribution of property and flavor] is hot, sweet, temperature.Return liver, kidney channel.

[function cures mainly] kidney-replenishing, bone and muscle strengthening, wind-damp dispelling.Be used for impotence and seminal emission, the muscles and bones flaccidity is soft, rheumatic arthralgia, numbness contracture; Climacteric hypertension.

Rhizoma Coptidis:

[meridian distribution of property and flavor] hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.

[function cures mainly] heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.The kind clear part of the body cavity above the diaphragm housing the heart and lungs of Rhizoma Coptidis (processed with wine) is burning hot.Be used for conjunctival congestion, aphtha.Prepared RHIZOMA COPTIDIS with rhizoma zingiberis recens juice clearing stomach stomach function regulating preventing or arresting vomiting.Be used for cold and heat and tie mutually, damp and hot middle resistance, feeling of fullness vomiting.Cornel Rhizoma Coptidis soothing liver-QI stomach function regulating preventing or arresting vomiting.Be used for incoordination between the liver and stomach, the vomiting acid regurgitation.

Radix Notoginseng:

[nature and flavor] are warm in nature, sweet in the mouth, little hardship.

The hemostasis of [function cures mainly] dissipating blood stasis, subduing swelling and relieving pain.Be used for various inside and outside hemorrhage, breast ventral spine pain, tumbling and swelling.

Rhizoma Chuanxiong:

[nature and flavor with return through] suffering, temperature.Return liver, gallbladder, pericardium channel.

[function with cure mainly] blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Radix Plumbaginis Zeylanicae:

[meridian distribution of property and flavor] is arduous puckery, and temperature is poisonous.1. " the SHENGCAO property of medicine is wanted fully ": " bitter in the mouth, cold in nature, nontoxic." 2. " the Guangxi medicine is planted figure will ": " acrid in the mouth, gas is strong, and is hot in nature, very toxic." 3. " Sichuan Chinese medicinal herbal ": " warm in nature, lightly seasoned, nontoxic." 4. " south of the Five Ridges herbal ": " slightly warm in nature; Rhizome: little puckery little hardship of distinguishing the flavor of; Leaf: peppery, poisonous." go into lung, spleen, liver three warps.

[effect] dispels the wind, dissipating blood stasis, detoxifcation, parasite killing.

[curing mainly] dispelling the wind and dampness pathogens arthralgia, blood stasis amenorrhea, traumatic injury, toxic swelling malignant boil, scabies.

Herba crotalariae mucronatae:

[meridian distribution of property and flavor] root: little hardship, suffering, flat.Seed: sweet, puckery, cold.Stem, leaf: bitter, hot, flat.

[function cures mainly] root: detoxicating and resolving stagnation of pathogens, removing food stagnancy.Be used for Lymph nodeTuberculosis, Mastitis, Dysentery, Infantile malnutritionSeed: invigorating the liver and kidney makes eye bright controlling nocturnal emission with astringent drugs.Be used for dizziness and blurred vision, neurasthenia, seminal emission, premature ejaculation, frequent micturition, the enuresis, leucorrhea.Stem, leaf: clearing heat and expelling damp.Be used for dysentery, damp-heat diarrhea.

Herba Sonchi Oleracei:

[meridian distribution of property and flavor] hardship, cold.1. " herbal classic ": " bitter in the mouth, cold." 2. " not Lu ": " nontoxic." go into the heart, spleen, stomach, large intestine channel; 1. " Bencao Jingshu ": " go into the heart, spleen, stomach three warps." 2. " book on Chinese herbal medicine is looked for the truth ": " go into the heart, stomach, large intestine.”

[effect cures mainly] heat clearing away, removing heat from blood, detoxifcation makes eye bright stomach function regulating, cough-relieving.Control dysentery, jaundice, stranguria with blood, hemorrhoid complicated by anal fistula, furuncle is swollen, venom, cough, bronchitis, infantile malnutrition.

Excellent effect of the present invention is:

Utilize the modern biological project theory, start with from changing the diabetics body constitution, regulate and the reinforcement tricarboxylic acid cycle, regulate the inside and outside sugared concentration of cell, strengthen the inside and outside sugared concentration of cell and become pump sample quick adjustment, regulate and remove the antagonism of cell to insulin, thereby give the information and instruction that excreting insulin was regulated and strengthened to pancreatic cell, diabetes are cured, and the effectively generation of prevent diabetes, the crowd that family's diabetic history is especially arranged is by taking the generation of avoiding diabetes with early prevention in advance.

Instructions of taking: 3 times on the one, each 2-3 grain, early, 30 minutes middle ante cibum the warm water clothes down, take before the sleep evening, one month is a course of treatment.Prohibit the gluttony crapulence, ban on opium-smoking and the opium trade wine, fasting sugar be can't help fruit.

The specific embodiment:

Embodiment 1

The medicine of treatment type ii diabetes of the present invention is made up of the drug extract of following weight portion ratio:

1 part of Herba Epimedii, 2 parts of propolis, 2 parts of Radix Puerariaes, 0.1 part of Fructus Vitis viniferae, 0.1 part in peach, 0.1 part of Herba crotalariae mucronatae

1 part of Radix Plumbaginis Zeylanicae, 8 parts of Semen sojae atricolor, 2 parts of Rhizoma Coptidis, 0.1 part of Radix Notoginseng, 0.1 part of Rhizoma Chuanxiong, 2 parts of Herba Sonchi Oleracei;

1) each composition preparation method of extract:

The preparation method of propolis extract:

By formula proportion freezing 24 hours of propolis → be crushed to 30-100 mesh sieve → stirring is added in the boiling water and to remove impurity → precipitate freezing 24 hours → to pulverize → be dissolved in 70% ethanol → filter → add ethanol to 85% dissolving 24 hours → filter → concentrate → drying → finished product.

The preparation method of Radix Puerariae extract: by formula proportion Radix Puerariae stripping and slicing → place 2-4 is doubly measured alcohol reflux 2 times → extract be concentrated into the neutral lead acetate of concentration of alcohol 15-20% → add leave standstill filtration → filtration filtrate add Lead monosubacetate leave standstill filter → filter → leach thing in 70% ethanol lead → filtering precipitate → place 1 time → crystal of 95% ethyl alcohol recrystallization to be drying to obtain.

C, peach extract: the ripe fruit 5-10 times of water gaging of squeezing the juice → add boils → puts cold filtration → adding lime water PH12 → sedimentation and filtration → precipitate and add suitable quantity of water dissolving back and add neutral lead acetate and leave standstill filtrations → filtrate adding Lead monosubacetate and leave standstill filtration → filter liquor and add ethanol to 70% filtration → filtrate and be concentrated into 1/3 volume and add ethanol to 95% → filter → leach thing to be drying to obtain.

2) other medicines extract composition extract according to a conventional method, dry, pulverize promptly.

3) each drug extract component is composite in proportion, after mix homogeneously, the drying, makes tablet, capsule.

Embodiment 2

The medicine of treatment type ii diabetes of the present invention is made up of the drug extract of following weight portion ratio:

7 parts of Herba Epimedii, 12 parts of propolis, 5 parts of Radix Puerariaes, 2 parts of Fructus Vitis viniferaes, 2 parts in peach, 12 parts of Herba Sonchi Oleracei

4 parts of Radix Plumbaginis Zeylanicaes, 15 parts of Semen sojae atricolor, 8 parts of Rhizoma Coptidis, 3 parts of Radix Notoginseng, 3 parts of Rhizoma Chuanxiongs, 5 parts of Herba crotalariae mucronataes;

Preparation method is identical with embodiment 1.

Embodiment 3

The medicine of treatment type of the present invention is made up of the drug extract of following weight portion ratio:

3 parts of Herba Epimedii, 4 parts of propolis, 3 parts of Radix Puerariaes, 1 part of Fructus Vitis viniferae, 1 part in peach, 5 parts of Herba Sonchi Oleracei

2 parts of Radix Plumbaginis Zeylanicaes, 10 parts of Semen sojae atricolor, 4 parts of Rhizoma Coptidis, 1 part of Radix Notoginseng, 1 part of Rhizoma Chuanxiong, 2 parts of Herba crotalariae mucronataes;

Preparation method is identical with embodiment 1.

Embodiment 4

The medicine of treatment type ii diabetes of the present invention is made up of the drug extract of following weight portion ratio:

5 parts of Herba Epimedii, 10 parts of propolis, 4 parts of Radix Puerariaes, 1.5 parts of Fructus Vitis viniferaes, 1.5 parts in peach, 9 parts of Herba Sonchi Oleracei;

3 parts of Radix Plumbaginis Zeylanicaes, 12 parts of Semen sojae atricolor, 7 parts of Rhizoma Coptidis, 3 parts of Radix Notoginseng, 2 parts of Rhizoma Chuanxiongs, 4 parts of Herba crotalariae mucronataes;

Preparation method is identical with embodiment 1.

Embodiment 5

The medicine of treatment type ii diabetes of the present invention is made up of the drug extract of following weight portion ratio:

4 parts of Herba Epimedii, 8 parts of propolis, 3.5 parts of Radix Puerariaes, 1.2 parts of Fructus Vitis viniferaes, 1.2 parts in peach, 7 parts of Herba Sonchi Oleracei,

2.5 parts of Radix Plumbaginis Zeylanicaes, 11 parts of Semen sojae atricolor, 5 parts of Rhizoma Coptidis, 2 parts of Radix Notoginseng, 1.5 parts of Rhizoma Chuanxiongs, 3 parts of Herba crotalariae mucronataes;

Preparation method is identical with embodiment 1.

Embodiment 6:

The medicine of treatment type of the present invention is made up of the drug extract of following weight ratio example:

Herba Epimedii 1g, propolis 2g, Radix Puerariae 2g, Fructus Vitis viniferae 0.1g, peach 0.1g, Semen sojae atricolor 8g,

Radix Plumbaginis Zeylanicae 1g, Rhizoma Coptidis 2g, Radix Notoginseng 0.1g, Rhizoma Chuanxiong 0.1g, Herba Sonchi Oleracei 2g, Herba crotalariae mucronatae 0.1g;

Embodiment 7:

Herba Epimedii 3g, propolis 4g, Radix Puerariae 3g, Fructus Vitis viniferae 1g, peach 1g, Semen sojae atricolor 10g,

Radix Plumbaginis Zeylanicae 2g, Rhizoma Coptidis 4g, Radix Notoginseng 1g, Rhizoma Chuanxiong 1g, Herba Sonchi Oleracei 5g; Herba crotalariae mucronatae 2g,

Preparation method is identical with embodiment 1.

Embodiment 8:

Herba Epimedii 4g, propolis 8g, Radix Puerariae 3.5g, Fructus Vitis viniferae 1.2g, peach 1.2g, Radix Plumbaginis Zeylanicae 2.5g,

Semen sojae atricolor 11g, Rhizoma Coptidis 5g, Radix Notoginseng 2g, Rhizoma Chuanxiong 1.5g, Herba crotalariae mucronatae 3g, Herba Sonchi Oleracei 7g;

Preparation method is identical with embodiment 1.

Embodiment 9:

Propolis 10g, Radix Puerariae 4g, Fructus Vitis viniferae 1.5g, peach 1.5g, Semen sojae atricolor 12g, Herba Epimedii 5g, Rhizoma Coptidis 7g,

Radix Notoginseng 3g, Rhizoma Chuanxiong 2g, Radix Plumbaginis Zeylanicae 3g, Herba crotalariae mucronatae 4g, Herba Sonchi Oleracei 9g;

Preparation method is identical with embodiment 1.

Embodiment 10:

Propolis 12g, Radix Puerariae 5g, Fructus Vitis viniferae 2g, peach 2g, Semen sojae atricolor 15g, Herba Epimedii 7g, Rhizoma Coptidis 8g,

Radix Notoginseng 3g, Rhizoma Chuanxiong 3g, Radix Plumbaginis Zeylanicae 4g, Herba crotalariae mucronatae 5g, Herba Sonchi Oleracei 12g;

Preparation method is identical with embodiment 1.

Clinical summary:

The inventor adopts the present invention to treat the medicine of type in 2004-2009, and 100 many cases diabeticss are treated, and obtains good result.With the capsule is example, and every day three times, each 2-3 is to grain, and one month be medical journey, takes effect in month of lacking of medical history, three the course of treatment blood glucose can recover normal; Medical history generally needs 6 courses of treatment more than 5 years, for medical history more than 10 years and patient that rely on insulin throughout the year, take 8-12 the course of treatment blood glucose can recover normal, take in the process, can reduce the dosage of insulin after one month gradually, three months insulins of can stopping using fully.Forbid the gluttony crapulence after taking medicine, ban on opium-smoking and the opium trade wine.On New Year's Day or other festivals food nutrition is abundant, and hyperalimentation can cause blood sugar increasing in short-term, obey again usually 1-3 the course of treatment blood glucose can recover normal.By clinical proof, the medicine effective percentage 100% of treatment type ii diabetes of the present invention, cure rate have patient's DeGrain of 2% more than 98%, and reason is by the custom of being addicted to drink.

Model case:

Case 1:

Liu xx, the man, 50 years old, height 1.72m, body weight 90kg, people from Jinan City, Shandong Province, weak 2 years of main cause is surplus, looks into fasting glucose 5.9mmol/L when in December, 2005 is in our unit's health check-up, does not make a definite diagnosis sugared dung disease.The patient is weak afterwards increases the weight of gradually, and obvious with two lower limb, can not alleviate after the rest.Go to a doctor for asking further the treatment on February 12nd, 2006.Existing main symptom: weak, obvious with two lower limb especially, two just transfer dimly red tongue, thin fur, stringy and thready pulse.Have a medical check-up: one demote situation can, blood pressure 130/85mmHg, the cardiopulmonary feminine gender of having a medical check-up.Previously body is strong, the happiness eating and drinking too much at one meal.Mother is a diabetics in the family.

Treatment process: take course of treatment of medicine of the present invention, empty wilful blood glucose 5.2mmol/L, the weak improvement of blood glucose 6.1mmol/L. in 3 hours after the meal.

After 3 courses of treatment, fasting glucose 5.3mmol/L weakly obviously alleviates.

After 5 courses of treatment, 2 hours after the meal blood glucose 7.1mmol/L, transference cure.

After 9 courses of treatment, conscious energetic, whole body is strong.

Therapeutic outcome: check on November 2nd, 2008 islet function is as follows:

1 hour after the meal 2 hours after the meal 3 hours after the meal on an empty stomach

Blood glucose (mmol/l) 4.8 10.1 6.3 5.9

Insulin (μ u/ml) 12.7 90.9 58.2 16.1

C-peptide (pmol/ml) 0.54 2.10 1.19 0.55

The patient satisfies withdrawal, normal diet.Looked in per two months in 1 year on an empty stomach and 2 hours after the meal blood glucose all in normal range.Follow up a case by regular visits to not recurrence so far.

Case 2:

Horse xx, the woman, 55 years old, people from Zhangqiu patient was put on the medicated cap of non-insulin-depending type (being the II type) diabetes before 13 years, over 13 years, blood glucose (2 hours after meal) fluctuates between 18.1mmol/L～25mmol/L always, twenty-four-hour urine sugar often floats between 7.8mmol/L～8.1mmol/L, simultaneously often with dizziness and tinnitus, edema of lower limbs, smart tired power is weary; Diarrhoea is often arranged, aversion to cold and cold limbs, shallow complexion, fat partially, frequent urination at night (3～4 times), hyposexuality, (it is poor to sleep, dreaminess for cholesterol total amount 10～15mmol/L, triglyceride 4～5mmol/L) for the blood fat height.Once took diamicron, insoral, glyburide, metformins etc. have certain effect, but blood glucose one landed vertically less than normal range, and glucose in urine is qualitative often to be "+" or " ++ ".Trial edition invention medicine in 2004 is after course of treatment, blood glucose descends obviously, 10mmol/L, glucose in urine "-", above-mentioned sign all disappears simultaneously, after 2 courses of treatment, blood glucose drops to 6mmol/L, twenty-four-hour urine sugar 2.2mmol/L, and the patient is very satisfied, take three courses of treatment later on continuously, conditions of patients is very stable at present.

Case 3:

Week xx, man, 43 years old, people from Jinan, Shandong, patient in February, 2004, thirsty happiness polydipsia, abnormal food appetite is vigorous, and hungry easily, and urine is frequently many, become thin obviously, body weight alleviated 10 kilograms in three months, and conscious Mental fatigue power is weary simultaneously, 2 hours after the meal blood glucose 25～30mmol/L, (normal＜6.7mmol/L), fasting glucose 12～15mmol/L, (normal＜4.6mmol/L), twenty-four-hour urine sugar 1.62mmol/d～6.2mmol/d, (normal＜5.4mmol/d), be diagnosed as type ii diabetes (insulin-dependent), in May in the same year, use the short-acting insulin injection for curing, blood glucose once descends to some extent, fails to drop to normal range but treat after 3 months blood glucose always.Simultaneously also took glyburide, glipizide, DeGrain begins to take medicine of the present invention in August, 2005, and blood glucose descends obviously after the course of treatment, blood glucose drops to normal range after 3 courses of treatment, glucose in urine "-", and antisecosis is obvious, spirit is rather good, hypourocrinia, and body weight rises gradually.Blood glucose maintains normal range always.

Case 4:

Permitted XX, woman, 60 years old, Jinan, Shandong, patient's in June, 2004 conscious breathing hard, weak, do not have spirit, happiness is drunk water, can not quench one's thirst again after drinking water, appetite is good, and fat body weight is become thin apparent in view, diabetes family members history is arranged, and hospital's blood sugar test is unusual, fasting glucose 8.2mmol/L, 2 hours after the meal blood glucose 10.3mmol/L, glucose in urine " ++ " was taken diamicron, restrain sugared profit etc., glycemic control is undesirable, and Mental fatigue power is weary, and frequent urination at night is improved not obvious, friend recommendation, trial edition invention pharmaceutical composition, blood glucose recovers normally gradually after the course of treatment, and glucose in urine is by " ++ " → "+", glucose in urine is by "+" → "-" after 3 courses of treatment, antisecosis, nocturia is slept by 4 times → 1 time, body weight rises gradually, and glycemic control is satisfied.

Case 5:

Open xx woman, 54 years old, patient's II type sugar history 3 years, it is dissatisfied to take antidiabetic drug such as glycemic control such as insoral, metformin for a long time, about the 2 hours after the meal blood glucose 9.1mmol/L, fasting glucose is paced up and down at 8.0mmol/L, and glucose in urine is between "+"～" ++ ", often insomnia, appetite still can, often accompany fatigue and weakness, sensation of oppression over the chest with shortness of breath, nocturia 3～4 times, edema of lower limbs.Conscious skin scorch pain since Spring Festival calendar year 2001, extremity are scurried pain and numb, hypertension, systolic pressure is increased to 180mmHg, diastolic pressure 110mmHg, urine examination albumen " +++", the microscopy hematuria, hospital diagnosis is occur together peripheral neuritis and nephropathy of diabetes, doctor trained in Western medicine gives vitamin B group except symptomatic treatment, depressor, diuretic, outside the analgesic, treatment means is caught shoulder and is seen elbow, take pharmaceutical composition of the present invention upon somebody's introduction, skin scorch pain alleviates after the course of treatment, and extremity are scurried pain and numb the improvement, and edema of lower limbs obviously alleviates after 3 courses of treatment, urine protein is by " +++" → "+", blood pressure falls 130mmHg/90mmHg after rise, and sleep improves, and appetite is normal, spirit is good, sensation of oppression over the chest with shortness of breath disappears, and blood glucose decline is 5.5mmol/L on an empty stomach, 2 hours after the meal 7.5mmol/L, twenty-four-hour urine sugar 6.2mmol/d, stable disease at present.

Case 6:

King XX, the man, 32 years old, the patient suffered from chronic hepatitis B and type ii diabetes 6 years, and liver function is unusual repeatedly, ALT80～100U., the Australia antigen positive often has uncomfortable liver area or pain, and blood glucose is often higher, fasting glucose＞13mmol/L, 2 hours after the meal blood glucose＞15mmol/L, glucose in urine between " +++" and " ++ ++ ", honey stomach, body obesity is (about 95 kilograms of body weight, 1.78 meters of heights) took antidiabetic drugs such as glyburide, metformin, diamicron, the glycemic control effect is dissatisfied, took multiple hepatoprotective simultaneously, as silybin, coenzyme A, it is not obvious that liver functions such as Aicamin are improved, began to take in 2004 pharmaceutical composition of the present invention after course of treatment blood glucose reduce to about 9.5mmol/L, blood glucose is reduced to 7.8mmol/L after three courses of treatment, and muscle power is clearly better.Liver function is normal, and Australia antigen is turned out cloudy, and glycemic control is in normal person's level, and uncomfortable liver area disappears.In high spirits, get up to 11 rests in evening for 6, hold a post in securities business the state of in the high-strung work of high pressure, still keeping fit.

Case 7:

Li Qing, the man, 36 years old, patient Spring Festival in 2006, conscious health was become thin later, lost weight obviously, and body weight drops to 75 kilograms for 80 kilograms in one month, honey stomach, happiness food fat meat, the tired power of Chang Xianjing is weary, cold perspiration, the blood sugar test fasting glucose 8.5mmol/L of hospital.Be diagnosed as type ii diabetes.Upon somebody's introduction, begin to take medicine of the present invention by the end of March, the weary transference cure of smart tired power after 2 courses of treatment.Work efficiency improves, and blood glucose detects for continuous three times, and all at 3.5～5.6mmol/L, body weight also has rebound significantly.

Claims (3)

1. preparation method for the treatment of the type ii diabetes medicine is characterized in that being made up of the following medicaments in part by weight extract:

Herba Epimedii 1-7 part, propolis 2-12 part, Radix Puerariae 2-5 part, Fructus Vitis viniferae 0.1-2 part, peach 0.1-2 part,

Radix Plumbaginis Zeylanicae 1-4 part, Semen sojae atricolor 8-15 part, Rhizoma Coptidis 2-8 part, Radix Notoginseng 0.1-3 part, Rhizoma Chuanxiong 0.1-3 part,

Herba crotalariae mucronatae 0.1-5 part, bright Herba Sonchi Oleracei 2-12 part;

Preparation method:

The preparation of propolis extract: freezing 24 hours of propolis → pulverized 100 mesh sieves → stirring added in the boiling water removed impurity → precipitate freezing 24 hours → pulverized the dissolve with ethanol 24 hours that the dissolve with ethanol 2 hours of 100 mesh sieves → add earlier, 70% concentration → filter filtering residue adds 85% concentration again → filter and collect twice filtrate evaporation and concentration to reclaim that ethanol → dry thing was pulverized 100 mesh sieves standby;

The preparation of Radix Puerariae extract: the neutral lead acetate of the 10% concentration ethanol reflux, extract, that the 2-4 that Radix Puerariae cut into slices → place doubly measures 2 times → be concentrated into concentration of alcohol 15-20% → add leave standstill 24 hours → filter filtrate add Lead monosubacetate leave standstill 24 hours → leach thing and add 70% concentration ethanol washing → filtering precipitate and place 1 time → crystal of 95% ethyl alcohol recrystallization drying for standby;

The preparation of peach extract: ripe bright peach enucleation squeeze the juice → add 5-10 times of water gaging boil → be chilled to room temperature filtration → adding lime water transfer pH=12 → sedimentation and filtration precipitate add suitable quantity of water dissolving back add neutral lead acetate leave standstill 6 hours filtrations → filtrate add Lead monosubacetate leave standstill 6 hours filtration → filtrate add leave standstill after 70% ethanol stirs 6 hours filtration → filtrate evaporation and concentration to 1/3 volumes → add, 95% ethanol stirring leave standstill 2 hours → filter → leach the thing drying for standby;

The preparation of Fructus Vitis viniferae extract: ripe fresh grape enucleation squeeze the juice → add 5-10 times of water gaging boil → be chilled to room temperature filtration → adding lime water transfer pH=12 → sedimentation and filtration → precipitate add suitable quantity of water dissolving back add neutral lead acetate leave standstill 6 hours filtrations → filtrate add Lead monosubacetate leave standstill 6 hours filtration → filtrate add leave standstill after 70% ethanol stirs 6 hours filtration → filtrate evaporation and concentration to 1/3 volumes → add, 95% ethanol stirring leave standstill 2 hours → filter → leach the thing drying for standby;

By traditional alcohol extraction prepared, it is standby that each extract drying was pulverized 100 mesh sieves respectively for the extract of Semen sojae atricolor, Herba Epimedii, Rhizoma Coptidis, Radix Notoginseng, Rhizoma Chuanxiong, Radix Plumbaginis Zeylanicae, Herba crotalariae mucronatae, bright each medicine of Herba Sonchi Oleracei;

Capsular preparation: it is even with the extract mixing of each herbal medicine to press formula proportion, incapsulates packing and is finished product.

2. preparation method according to claim 1 is characterized in that, is made up of the following medicaments in part by weight extract:

Herba Epimedii 3-5 part, propolis 4-10 part, Radix Puerariae 3-4 part, Fructus Vitis viniferae 1-1.5 part, peach 1-1.5 part,

Radix Plumbaginis Zeylanicae 2-3 part, Semen sojae atricolor 10-12 part, Rhizoma Coptidis 4-7 part, Radix Notoginseng 1-3 part, Rhizoma Chuanxiong 1-2 part,

Herba crotalariae mucronatae 2-4 part, Herba Sonchi Oleracei 5-9 part.

3. preparation method according to claim 2, its feature also are, are made up of the following medicaments in part by weight extract:

4 parts of Herba Epimedii, 8 parts of propolis, 3.5 parts of Radix Puerariaes, 1.2 parts of Fructus Vitis viniferaes, 1.2 parts in peach,

2.5 parts of Radix Plumbaginis Zeylanicaes, 11 parts of Semen sojae atricolor, 5 parts of Rhizoma Coptidis, 2 parts of Radix Notoginseng, 1.5 parts of Rhizoma Chuanxiongs,

3 parts of Herba crotalariae mucronataes, 7 parts of bright Herba Sonchi Oleracei.