CN101700027A - Synergistic bactericidal composition and application - Google Patents
Synergistic bactericidal composition and application Download PDFInfo
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- CN101700027A CN101700027A CN200910310641A CN200910310641A CN101700027A CN 101700027 A CN101700027 A CN 101700027A CN 200910310641 A CN200910310641 A CN 200910310641A CN 200910310641 A CN200910310641 A CN 200910310641A CN 101700027 A CN101700027 A CN 101700027A
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- polyoxin
- cyanogen frost
- frost azoles
- bactericidal composition
- synergistic bactericidal
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Abstract
The invention belongs to the technical field of pesticide, in particular to a bactericidal composition containing polyoxin and cyazofamid which are compounded and an application. The synergistic bactericidal composition adopts the polyoxin and the cyazofamid to be compounded to act a synergistic action, is used for preventing and treating various diseases on crops, such as melons, fruit, vegetables and the like, has the advantages of wide application range, low cost, good effect, resistibility delaying of pathogenic bacteria, high bactericidal activity and the like and especially has very good preventing and treating effect to downy mildew and blight.
Description
Technical field
The invention belongs to technical field of pesticides, be specifically related to a kind of contain polyoxin and composite bactericidal composition and the application of cyanogen frost azoles.
Background technology
The downy mildew that is produced by the Oomycete fungal attack, eqpidemic disease are the multiple diseases of protection ground vegetables and other crop (as grape, strawberry, potato etc.); have infectivity, infect soon; develop characteristics such as rapid, wayward, often cause a large amount of underproduction even total crop failure to crops.In recent years along with the increasing of China fruit tree and growing vegetables area; especially the large tracts of land of vegetable protecting field culture technique is promoted; make the incidence and the occurring degree of crop pest all be significantly increased; vegetable disease such as cucumber downy mildew and tomato blight has become the No.1 killer in the protection ground growing vegetables; often cause mashed leaf, decayed fruit, so complete stool death.The frequent frequency of utilization of bactericide that makes of disease constantly increases, and the dispenser of high frequency time makes germ produce more and more stronger drug resistance, thereby cause vicious circle, conventional dose such as carbendazim, aliette etc. can not effectively be controlled such disease, and some former efficient kinds such as metalaxyl, Propamocarb etc. are to the control efficiency of downy mildew also worse and worse.
The composition of different cultivars carries out composite, is the common way of preventing and treating the resistance germ, according to practical application effect, judge certain composite be synergy, addition or antagonism.Composite effect is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation of germ greatly, and be the important means of integrated control disease.
Cyanogen frost azoles (Cyazofamid) chemical name 4-chloro-2-cyano group-5-p-methylphenyl-imidazoles-1-N, N-dimethyl methyl acid amides belongs to the imidazoles bactericide.Cyanogen frost azoles is the mitochondrial respiratory inhibitor; all vegetative stages of oomycetes all there is effect; the germ that metalaxyl is produced resistance or sensitivity all has activity; and it is active to have good protection; lasting period is long, and resistance of rainwater washing against is to crop, the mankind, Environmental security; but long-term single use can make germ that it is developed immunity to drugs unavoidably.
Polyoxin (Polyoxin) claim multi-effect mycin again, chemical name peptide pyrimidine nucleoside, belong to the broad-spectrum antibiotics series bactericidal agent, can disturb the chitinous biosynthesis of germ cell wall, germ tube is with after mycelia contacts medicament, and cell inclusion is expanded, breaks, overflowed in the part, and can not normal development, also can suppress germ and produce spore and scab expansion, can prevent and treat multiple diseases such as eliminating vegetable botrytis, downy mildew, eqpidemic disease, inhale conduction in having.
The long-term use separately of above-mentioned two kinds of medicaments causes germ to develop immunity to drugs easily; bactericidal activity is reduced greatly; and can not have better protect and therapeutic activity concurrently, control efficiency is unsatisfactory, has not yet to see the relevant report of the composite product of polyoxin and cyanogen frost azoles.
Summary of the invention
The objective of the invention is provides a kind of Synergistic bactericidal composition and application at the problems referred to above, said composition adopts polyoxin and cyanogen frost azoles to carry out composite, play synergistic function, be used for preventing and treating the multiple diseases on the crops such as melon and fruit, vegetables, applied widely, cost is low, effective, especially downy mildew, eqpidemic disease there are good control efficiency, have the germ of delaying resistance and bactericidal activity advantages of higher.
Among the present invention, the weight that the cyanogen frost azoles of being mentioned, the weight of polyoxin and Fungicidal active substance are total etc. all refer to the weight of rolling over after hundred, i.e. the weight of active principle.
Synergistic bactericidal composition of the present invention contains Fungicidal active substance polyoxin and cyanogen frost azoles.
Wherein, the weight ratio of described Fungicidal active substance polyoxin and cyanogen frost azoles is polyoxin: cyanogen frost azoles=1: 1-1: 100.
As preferably, the weight ratio of described Fungicidal active substance polyoxin and cyanogen frost azoles is polyoxin: cyanogen frost azoles=1: 5～1: 20.
In the said composition, the total weight percentage of described Fungicidal active substance is 1%～90%.
Composition of the present invention adds auxiliary agent and excipient, makes according to the method that those skilled in the art were familiar with to be fit to agricultural and to go up the formulation of using, and preferably formulation is wetting powder, suspending agent and water dispersible granules.
Synergistic bactericidal composition of the present invention is used to prevent and treat the disease on melon and fruit, the vegetable crop, can prevent and treat the multiple diseases on melon and fruit, the vegetable crop, especially downy mildew, eqpidemic disease is had good control efficiency.
The present invention carries out polyoxin and cyanogen frost azoles bactericide composite, and cyanogen frost azoles is the mitochondrial respiratory inhibitor, and polyoxin belongs to the antibiotics bactericide, because mechanism of action difference between the two has delayed the drug-fast generation of germ greatly; And complex preparation has higher protection and therapeutic activity concurrently; improve bactericidal effect greatly, had obvious role in synergism, thereby reduced dosage and drug cost; reduced harmful effect, thereby this complex composition have tangible economic benefit and environmental benefit to environment.In a word, this complex composition is used for preventing and treating the multiple diseases on the crops such as melon and fruit, vegetables, applied widely, cost is low, effective, especially downy mildew, eqpidemic disease are had good control efficiency, have the germ of delaying resistance and bactericidal activity advantages of higher.
Measure polyoxin and the indoor virulence of the white azoles list of cyanogen mixture in indoor employing plate blade method to bacterium of downy mildew of cucumber.Test method: cucumber leaves is placed the culture dish processing of preserving moisture, dosage by design sprays medicament respectively, inoculate bacterium of downy mildew of cucumber after 24 hours, and the cultivation of in incubator, preserving moisture, 7d " Invest, Then Investigate " preventive effect, calculate control efficiency with disease index, carry out statistical analysis with the DPS data processing software, calculate the EC50 of each medicament, adopt the abundant method calculating co-toxicity coefficient of Sun Yun (CTC) to estimate and use effect with, the CTC value has synergistic effect greater than 120 o'clock mixtures, less than 80 o'clock be antagonism, have summation action in the time of between 80～120.
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) * B the percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
Test data is as follows:
Table 1 polyoxin and cyanogen frost azoles list mixture are to the toxicity test of bacterium of downy mildew of cucumber
| Reagent agent | The active ingredient weight ratio | ??EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Polyoxin | ??- | ??20.86 | ??- |
| Cyanogen frost azoles | ??- | ??8.72 | ??- |
| Polyoxin: cyanogen frost azoles | ??1∶1 | ??12.32 | ??199.65 |
| Polyoxin: cyanogen frost azoles | ??1∶5 | ??8.18 | ??236.10 |
| Reagent agent | The active ingredient weight ratio | ??EC50(mg/L) | Co-toxicity coefficient (CTC) |
| Polyoxin: cyanogen frost azoles | ??1∶10 | ??7.13 | ??258.26 |
| Polyoxin: cyanogen frost azoles | ??1∶20 | ??6.89 | ??260.33 |
| Polyoxin: cyanogen frost azoles | ??1∶40 | ??8.27 | ??213.91 |
| Polyoxin: cyanogen frost azoles | ??1∶80 | ??9.36 | ??187.67 |
| Polyoxin: cyanogen frost azoles | ??1∶100 | ??11.46 | ??153.06 |
By table 1 as seen, polyoxin and cyanogen frost azoles are composite, bacterium of downy mildew of cucumber had good indoor virulence, the CTC value of seven proportionings is all above 120, show that these two bactericide have good synergistic effects under this proportioning, simultaneously also as can be seen in composition different its synergistic effects along with polyoxin and the white azoles ratio of cyanogen also be different, mixed ratio synergy between 1: 5～1: 20 is particularly remarkable.
Embodiment
The invention will be further described below in conjunction with embodiment, but the present invention is not limited thereto, and the formulation preparation method among the embodiment is conventional method.
Embodiment 1:9% polyoxin cyanogen frost azole suspending agent comprises following component by weight:
Polyoxin 1.5%
Cyanogen frost azoles 7.5%
Alkyl naphthalene formaldehyde condensate sulfonates 1%
Polyoxyethylene nonylphenol ether 1%
Xanthans 0.3%
Benzoic acid 0.1%
Organosilan defoamer 0.3%
Water surplus
With whole mixing of materials, the back that stirs joins sand mill to material and carries out sand milling, makes material reach 2～5 μ m fineness, makes 9% polyoxin cyanogen frost azole suspending agent.
Embodiment 2:21% polyoxin cyanogen frost azoles water dispersible granules comprises following component by weight:
Polyoxin 1%
Cyanogen frost azoles 20%
Sodium lignin sulfonate 6%
PO-EO block polyether 4%
Lauryl sodium sulfate 3%
Ammonium sulfate 4%
The precipitated calcium carbonate surplus
The ratio of said components in prescription mixed, become wetting powder, add a certain amount of water mixing extruder grain again, obtain 21% polyoxin cyanogen frost azoles water dispersible granules after the drying screening through comminution by gas stream.
Embodiment 3:80% polyoxin cyanogen frost azoles wetting powder comprises following component by weight:
Polyoxin 1%
Cyanogen frost azoles 79%
To methoxyl group fatty acid Sodium p-aminobenzene sulfonat 1%
Sodium methylene bis-naphthalene sulfonate 2%
White carbon 2.5%
The kaolin surplus
Said components is mixed into promoting the circulation of qi stream pulverizes, make 80% polyoxin cyanogen frost azoles wetting powder.
Test example: the test of pesticide effectiveness that polyoxin and the mixture of the different proportionings of cyanogen frost azoles are prevented and treated tomato late blight
Several mixtures that the embodiment of the invention is obtained carry out the test of pesticide effectiveness, adopt the greenhouse pot culture tomato seedling, measure the control efficiency of single mixture of polyoxin and cyanogen frost azoles to tomato late blight.When tomato grows to 3～4 leaves, select the blade of growing way uniformity to adopt manual sprayer to carry out the foliar spray processing, inoculate pathogen after 24 hours, preserve moisture and cultivate 7d " Invest, Then Investigate " result, the results are shown in Table 2.
The mixture of the different proportionings of table 2 polyoxin and cyanogen frost azoles is to the control efficiency of tomato late blight
| Reagent agent | Dosage (μ g/mL) | Disease index | Control efficiency (%) |
| Embodiment 1 product | ??200 | ??11.94 | ??82.13 |
| Embodiment 2 products | ??200 | ??12.28 | ??81.62 |
| Embodiment 3 products | ??200 | ??13.22 | ??80.21 |
| 20% polyoxin suspending agent | ??200 | ??17.86 | ??73.27 |
| 20% cyanogen frost azole suspending agent | ??200 | ??16.74 | ??74.94 |
| The clear water contrast | ??- | ??66.82 | ??- |
As can be seen from Table 2, the mixture preparation of polyoxin and cyanogen frost azoles can effectively be prevented and treated tomato late blight, and obviously is better than the control efficiency of single agent.
As can be seen from the above embodiments, polyoxin of the present invention and cyanogen frost azoles composition are in certain ratio range, has good synergistic effects, eqpidemic disease there is good control efficiency, thereby can reduce the usage amount of medicine, reduce residue of pesticide, reduce influence degree, play environmental protection, effect efficiently environment.
Claims (7)
1. a Synergistic bactericidal composition contains Fungicidal active substance polyoxin and cyanogen frost azoles.
2. Synergistic bactericidal composition according to claim 1 is characterized in that, the weight ratio of described Fungicidal active substance polyoxin and cyanogen frost azoles is polyoxin: cyanogen frost azoles=1: 1-1: 100.
3. Synergistic bactericidal composition according to claim 2 is characterized in that, the weight ratio of described Fungicidal active substance polyoxin and cyanogen frost azoles is polyoxin: cyanogen frost azoles=1: 5～1: 20.
4. according to claim 1 or 2 or 3 described Synergistic bactericidal compositions, it is characterized in that the total weight percentage of described Fungicidal active substance is 1%～90%.
5. Synergistic bactericidal composition according to claim 4, said composition formulation are wetting powder, suspending agent and water dispersible granules.
6. according to the described Synergistic bactericidal composition of claim 1, be used to prevent and treat the multiple diseases on melon and fruit, the vegetable crop.
7. according to the described Synergistic bactericidal composition of claim 1, be used to prevent and treat downy mildew, eqpidemic disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910310641 CN101700027B (en) | 2009-11-30 | 2009-11-30 | Synergistic bactericidal composition and application |
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| CN 200910310641 CN101700027B (en) | 2009-11-30 | 2009-11-30 | Synergistic bactericidal composition and application |
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| CN101700027A true CN101700027A (en) | 2010-05-05 |
| CN101700027B CN101700027B (en) | 2013-04-17 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067873A (en) * | 2011-02-19 | 2011-05-25 | 陕西美邦农药有限公司 | Bactericidal composition containing polyoxin and triazole compound |
| CN103918658A (en) * | 2014-04-24 | 2014-07-16 | 深圳诺普信农化股份有限公司 | Compound bactericide composition containing cyazofamid |
| CN103947662A (en) * | 2014-04-29 | 2014-07-30 | 深圳诺普信农化股份有限公司 | Fungicidal composition |
| CN107333782A (en) * | 2017-07-05 | 2017-11-10 | 南京红太阳股份有限公司 | A kind of bactericidal composition and its application of the pyrrole bacterium ketone of benzene containing amine and cyazofamid |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0418047D0 (en) * | 2004-08-12 | 2004-09-15 | Syngenta Participations Ag | Fungicidal compositions |
| CN1327770C (en) * | 2005-11-28 | 2007-07-25 | 北京绿色农华植保科技有限责任公司 | Sterilization composition containing carbendazim of multiple antimycin |
-
2009
- 2009-11-30 CN CN 200910310641 patent/CN101700027B/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067873A (en) * | 2011-02-19 | 2011-05-25 | 陕西美邦农药有限公司 | Bactericidal composition containing polyoxin and triazole compound |
| CN103918658A (en) * | 2014-04-24 | 2014-07-16 | 深圳诺普信农化股份有限公司 | Compound bactericide composition containing cyazofamid |
| CN103918658B (en) * | 2014-04-24 | 2015-08-12 | 深圳诺普信农化股份有限公司 | A kind of combination sterilization composition containing cyazofamid |
| CN103947662A (en) * | 2014-04-29 | 2014-07-30 | 深圳诺普信农化股份有限公司 | Fungicidal composition |
| CN107333782A (en) * | 2017-07-05 | 2017-11-10 | 南京红太阳股份有限公司 | A kind of bactericidal composition and its application of the pyrrole bacterium ketone of benzene containing amine and cyazofamid |
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|---|---|
| CN101700027B (en) | 2013-04-17 |
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Address after: 266228 Qingdao City, Shandong province Laixi City, Jiang Shan town before the village (Busan Industrial Park) Applicant after: Qingdao Star Cropscience Co., Ltd. Address before: 266071, room 4, building 133, Ting capital building, No. 312, Fuzhou North Road, Qingdao, Shandong Applicant before: Qingdao Star Cropscience Co., Ltd. |
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