CN101683468B - Medicament for treating burns and scalds and preparation method thereof - Google Patents
Medicament for treating burns and scalds and preparation method thereof Download PDFInfo
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- CN101683468B CN101683468B CN2008101430073A CN200810143007A CN101683468B CN 101683468 B CN101683468 B CN 101683468B CN 2008101430073 A CN2008101430073 A CN 2008101430073A CN 200810143007 A CN200810143007 A CN 200810143007A CN 101683468 B CN101683468 B CN 101683468B
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Abstract
The invention discloses a medicament for treating burns and scalds. The medicament is mainly prepared from rheum officinale, earthworm, bletilla, myrrh, Cape jasmine, borneol, frankincense, mint and peony tree root bark according to a certain weight ratio. The medicament can be prepared into a frequently-used externally applied drug. The medicament has the functions of clearing away heat, reducing fire, diminishing inflammation, resisting bacteria, invigorating the circulation of blood, removing blood stasis, removing putrefaction, promoting tissue regeneration, relieving the exterior syndrome with drugs pungent in flavor and cool in property and astringing stop bleeding, has quick effect on treating the burns and the scalds, no scars and high curative ratio and is a preferred medicament for treating the burns and the scalds.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of burn and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Burn is a kind of disease that often occurs in the daily life, and the many knotty problems of clinical appearance are perplexing the patient.The burn skin rehabilitation medicine for treating that the number of patenting 01106445 Chen Yan woods, Li Xizhen produce is to be produced by Adeps Serpentis etc., watches for animals yet Serpentis is country's one, two classes, and producing this medicine will be restricted.Also some medicine is the function of heat-clearing and toxic substances removing, detumescence and promoting granulation, can only shorten the course of disease.However, these medicines all can not reach satisfactory effect.
Summary of the invention
Therefore, people better treat curative effect, still there is very big demand in the Chinese medicine preparation of burn, so far also do not find any about with the report of pharmaceutical composition of the present invention, the inventor is through research repeatedly, and, assert the special effect of medicine of the present invention finally, thereby finished the present invention by clinical trial over more than 20 years and checking repeatedly.
The invention provides a kind of Chinese medicine composition preparation method of more efficiently treatment burn.Medicament selection of the present invention Olibanum, Myrrha, Cortex Moutan, make each efficacy of drugs produce synergism these drug regimens, thereby reach the effect of promoting blood circulation and stopping pain, detumescence blood stasis dispelling effectively.This three flavors medicine is monarch.Select Radix Et Rhizoma Rhei, the Pseudobulbus Bletillae (Rhizoma Bletillae), Pheretima for use.Radix Et Rhizoma Rhei has all has inhibitory action to gold-coloured staphylococci, bacillus pyocyaneus, Diplococcus pneumoniae, diphtheria corynebacterium, anthrax bacillus, escherichia coli, dermatophytes, Pseudobulbus Bletillae (Rhizoma Bletillae) astringing to arrest bleeding, detumescence, granulation promoting, oral administration and externally all has better hemostasia and promoting granulation effect, selects Pheretima to be because the effect of heat clearing away, relieving convulsion, active blood stasis dispelling is arranged.
In order better to reach curative effect, medicine of the present invention also makes up with Fructus Gardeniae, Herba Menthae, Borneolum Syntheticum, is the merit of the skin feverish skin because Fructus Gardeniae is dispelled simply, Herba Menthae has the Xin Liang effect, the Borneolum Syntheticum removing the necrotic tissue and promoting granulation, more than the common assistant of three flavor medicines help the monarch and his subjects' product, analgesic detumescence reaches the anticorrosion merit of sterilization.
The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and each group component has curative effect preferably in following weight parts scope portion:
Radix Et Rhizoma Rhei 2-5 part, Pheretima 2-5 part, Myrrha 1-3 part, Olibanum 5-10 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part.
Be preferably: 3 parts of Radix Et Rhizoma Rhei, 3 parts of Pheretimas, 2 parts of Myrrhas, 10 parts of Olibanums, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s.
Each group component of the present invention can also be Radix Et Rhizoma Rhei 2-5 part, Pheretima 2-5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Myrrha 1-3 part, Olibanum 5-10 part, Fructus Gardeniae 3-6 part, Borneolum Syntheticum 0.1-0.5,, Cortex Moutan 5-10 part, Herba Menthae 2-5 part.
Be preferably: 3 parts of Radix Et Rhizoma Rhei, 5 parts of Pheretimas, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 2 parts of Myrrhas, 10 parts of Olibanums, 3 parts of Fructus Gardeniae, 0.25 part of Borneolum Syntheticum, 10 parts of Cortex Moutans, 5 parts of Herba Menthaes.
Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional external preparation.Preferably, the preparation method of medicine activity component of the present invention is as follows:
A) take by weighing each crude drug Radix Et Rhizoma Rhei, Pheretima, Olibanum, Borneolum Syntheticum and the Pseudobulbus Bletillae (Rhizoma Bletillae), standby;
B) Pheretima of described weight proportion, Olibanum, the Pseudobulbus Bletillae (Rhizoma Bletillae) three flavor medicines are added the water intense fire and boil and fry in shallow oil 3 hours, each amount of water was not advisable for 3 centimetres to have powder;
C) the Radix Et Rhizoma Rhei Herba indigoferae Pseudotinctoriae of described weight proportion is added hydrology fire and boil and fry in shallow oil 20 minutes, each amount of water was not advisable for 3 centimetres to have powder;
D) described medicine is crossed leaching liquid, in the time of should 60-70 ℃ Borneolum Syntheticum be put into medicinal liquid simply, just be prepared into the active component of medicine of the present invention.
If also with Myrrha, Fructus Gardeniae, Herba Menthae, Cortex Moutan combination, its preparation method is:
A) take by weighing each crude drug Radix Et Rhizoma Rhei, Pheretima, Olibanum, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Fructus Gardeniae, Herba Menthae, Cortex Moutan, standby.
B) Pheretima, Olibanum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, the Cortex Moutan five kinds of Chinese medicine of described weight proportion added the water intense fire and boil and fry in shallow oil 3 hours, each amount of water was not advisable for 3 centimetres to have powder;
C) Fructus Gardeniae of described drug ratio, Herba Menthae two flavor medicines are added hydrology fire and boil and fry in shallow oil 30 minutes, each amount of water was not advisable for 3 centimetres to have powder;
D) the Radix Et Rhizoma Rhei Herba indigoferae Pseudotinctoriae of described weight proportion is added hydrology fire and boil and fry in shallow oil 20 minutes, each amount of water was not advisable for 3 centimetres to have powder;
E) described medicine is crossed leaching liquid, in the time of should 60-70 ℃ Borneolum Syntheticum be put into medicinal liquid simply, just be prepared into the active component of medicine of the present invention.
The specific embodiment
The external therapy of Chinese herb burn has long history, and the external treatment burn is a kind of necessary means in the treatment, and general burn and scald is divided into three district's bands: middle body is the coagulation necrosis band, and outer peripheral portion is the congestion and edema band, is the blood flow blood stasis and stagnant zone between two bands.For this reason, I sum up the secret recipe of finding, invented the Chinese medicine burn according to these states.Successively cure patient's 245 examples, male's 185 examples, women's 60 examples; Workman's 110 examples, dining room personnel 98 examples, driver's 8 examples, student's 18 examples, beauty parlor's 5 examples, peasant's 6 examples.
The therapeutical effect that [test example 1] medicine of the present invention is scalded rabbit skin surface due to artificial
Test material:
Anthology invention medicine; Liquid for treating scald, lot number 080301 is produced by Shaanxi Pharmaceutical group company.
Test method:
Get 30 of rabbit, the male and female dual-purpose, body weight 2.0-2.5kg, one scald gently at the skin surface of rabbit with the red flatiron of prior burning, diameter 2cm is scalded in modeling in about 2 seconds, after the modeling rabbit is divided into 3 groups, every group 10, wherein 2 groups is the treatment groups of using medicine of the present invention, and 1 group for using the treatment matched group of liquid for treating scald.
The cleaning wound location immerses respectively in the medicinal liquid that medicine of the present invention and liquid for treating scald are housed with sterile gauze, spreads on the wound surface place, the anti-staphylococcus aureus of reuse Western medicine drug, anti-anaerobic bacillus(cillus anaerobicus) medicine injection for curing.Observed result sees the following form:
| Group | The test number | Treatment time | Cicatrix | Inflammation | Effect |
| Treatment group 1 | 10 | 8 | Do not have | Do not have | Good |
| Treatment group 1 | 10 | 8 | Do not have | Do not have | Good |
| Matched group | 10 | 12 | Have | Slightly | Difference |
The result shows, perusal and check pathological section as seen, treatment group and treatment matched group relatively, rabbit skin surface due to artificial scalded the obvious treatment effect.
[test example 2]
The patient, Deng, the man, 45 years old, burn caught fire in family July 18 calendar year 2001.
The state of an illness: two-sided and forehead and breast top burn, forehead II degree burn, left hand arm stage casing deep ii degree burn, two lower limb, knee joint are burnt to ankle joint III degree, 37.5 ℃ of axillaty temperatures, respiratory quotient is more normal.
Processing method: at first clear up wound location, immerse with sterile gauze in the burn medicinal liquid of preparation according to said method, spread on the wound surface place, the anti-staphylococcus aureus of reuse Western medicine drug, anti-anaerobic bacillus(cillus anaerobicus) medicine injection for curing.After 2 hours, the patient suffering disappears, and wound surface does not have edema.Removed gauze in second day, exposure method is applied to wound surface repeatedly with this invention medicinal liquid.Western medicine drug is with anti-staphylococcus aureus, anti-anaerobic bacillus(cillus anaerobicus) medicine injection for curing.Wound surface begins incrustation in ten hours, and all are normal for the patient.Symptomatic treatment recovery from illness in 18 days.
The result: wound surface has pigment, no cicatrix.
Visit: after 4 months, Deng's non-pigment calmness, epidermis is excellent, no cicatrix (more than have in advance photo for demonstrate,proving) afterwards.
[test example 3]
The patient, Xiao, the man, 48 years old, calendar year 2001 changed here over to from County Hospital by the end of October.Xiao treated nearly 20 days in county people's hospital earlier at brickkiln factory burn on October calendar year 2001 8, had little effect, and thought the provincial hospital skin-grafting, introduced through the friend, changed here over to.
The state of an illness: two lower limb gastrocnemiuss are rotted, and right crus of diaphragm heel tendon exposes, and belong to dark III degree burn, 38.5 ℃ of axillaty temperatures, and blood pressure is normal.
Processing method: clean the original burn cream of usefulness at once, coat burn medicinal liquid of the present invention.Doctor trained in Western medicine is used anti-staphylococcus aureus, anti-anaerobic bacillus(cillus anaerobicus) medicine injection for curing, and wound surface is progressively formed a scab in 15 hours.Continue symptomatic treatment after 25 days, the wound surface recovery from illness.
The result: no cicatrix has pigment.After visiting 4 months, non-pigment calmness, epidermis excellent (more than have in advance afterwards photo is card).
Come further to set forth the preparation method of medicine of the present invention by the following examples.
The externally used solution dosage form preparation of [test example] medicine of the present invention
A) take by weighing each crude drug Radix Et Rhizoma Rhei 3g, Pheretima 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 10g, Myrrha 2g, Olibanum 10g, Fructus Gardeniae 3g, Borneolum Syntheticum 0.25g, Cortex Moutan 10g, Herba Menthae 5g, standby.
B) Pheretima, Olibanum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, the Cortex Moutan five kinds of Chinese medicine of described weight proportion added the water intense fire and boil and fry in shallow oil 3 hours, each amount of water was not advisable for 3 centimetres to have powder;
C) Fructus Gardeniae of described drug ratio, Herba Menthae two flavor medicines are added hydrology fire and boil and fry in shallow oil 30 minutes, each amount of water was not advisable for 3 centimetres to have powder;
D) the Radix Et Rhizoma Rhei Herba indigoferae Pseudotinctoriae of described weight proportion is added hydrology fire and boil and fry in shallow oil 20 minutes, each amount of water was not advisable for 3 centimetres to have powder;
E) described medicine is crossed leaching liquid, it is good that the burn medicinal liquid should remain on the 300-400 milliliter, in the time of should 60-70 ℃ Borneolum Syntheticum be put into medicinal liquid simply, just has been prepared into the active component of medicine of the present invention.
Claims (8)
1. a medicine for the treatment of burn is characterized in that it mainly is to be made by following raw materials in weight: Radix Et Rhizoma Rhei 2-5 part, Pheretima 2-5 part, Olibanum 5-10 part, Borneolum Syntheticum 0.1-0.5 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-10 part, Myrrha 1-3 part, Fructus Gardeniae 3-6 part, Herba Menthae 2-5 part and Cortex Moutan 5-10 part.
2. according to the medicine of claim 1, wherein the consumption of crude drug is: 10 parts of 3 parts of Radix Et Rhizoma Rhei, 4.5 parts of Pheretimas, 8 parts of Olibanums, 0.2 part of Borneolum Syntheticum and the Pseudobulbus Bletillae (Rhizoma Bletillae)s.
3. according to the preparation method of claim 1 or 2 described medicines, it comprises the following steps:
A) take by weighing each crude drug Radix Et Rhizoma Rhei, Pheretima, Olibanum, Borneolum Syntheticum and the Pseudobulbus Bletillae (Rhizoma Bletillae), standby;
B) Pheretima of described weight proportion, Olibanum, the Pseudobulbus Bletillae (Rhizoma Bletillae) three flavor medicines are added the water intense fire and boil and fry in shallow oil 3 hours, each amount of water was not to have 3 centimetres of powder;
C) the Radix Et Rhizoma Rhei Herba indigoferae Pseudotinctoriae of described weight proportion is added hydrology fire and boil and fry in shallow oil 20 minutes, each amount of water was not to have 3 centimetres of powder;
D) described medicine is crossed leaching liquid, in the time of 60-70 ℃, Borneolum Syntheticum is put into medicinal liquid simply.
4. medicine according to claim 1, wherein crude drug also has: Myrrha 1-3 part, Fructus Gardeniae 3-6 part, Herba Menthae 2-5 part, Cortex Moutan 5-10 part.
5. medicine according to claim 4, wherein the consumption of each component is: 3 parts of Radix Et Rhizoma Rhei, 4.5 parts of Pheretimas, 8 parts of Olibanums, 0.2 part of Borneolum Syntheticum, 10 parts of the Pseudobulbus Bletillae (Rhizoma Bletillae)s, 2 parts of Myrrhas, 4 parts of Fructus Gardeniaes, 4 parts of Herba Menthaes, 10 parts of Cortex Moutans.
6. the preparation method of claim 4 or 5 described medicines, it comprises the following steps:
A) take by weighing each crude drug Radix Et Rhizoma Rhei, Pheretima, Olibanum, Borneolum Syntheticum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, Fructus Gardeniae, Herba Menthae, Cortex Moutan, standby.
B) Pheretima, Olibanum, the Pseudobulbus Bletillae (Rhizoma Bletillae), Myrrha, the Cortex Moutan five kinds of Chinese medicine of described weight proportion added the water intense fire and boil and fry in shallow oil 3 hours, each amount of water was not to have 3 centimetres of powder;
C) Fructus Gardeniae of described drug ratio, Herba Menthae two flavor medicines are added hydrology fire and boil and fry in shallow oil 30 minutes, each amount of water was not to have 3 centimetres of powder;
D) the Radix Et Rhizoma Rhei Herba indigoferae Pseudotinctoriae of described weight proportion is added hydrology fire and boil and fry in shallow oil 20 minutes, each amount of water was not to have 3 centimetres of powder;
E) described medicine is crossed leaching liquid, in the time of 60-70 ℃, Borneolum Syntheticum is put into medicinal liquid simply.
7. according to claim 3 or 6 described methods, wherein at 3.c), 6.d) medicine decocted with water extraction in the step before, add 8 times of amounts of water each time, add 6 times of amounts of water the 2nd time.
8. according to claim 3 or 6 described methods, institute's taking liquid is preserved in 8-25 ℃ of shading.Then become the medicine of my invention.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101430073A CN101683468B (en) | 2008-09-26 | 2008-09-26 | Medicament for treating burns and scalds and preparation method thereof |
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| CN2008101430073A CN101683468B (en) | 2008-09-26 | 2008-09-26 | Medicament for treating burns and scalds and preparation method thereof |
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| CN101683468B true CN101683468B (en) | 2011-08-03 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326546C (en) * | 2005-02-28 | 2007-07-18 | 张岚 | Pure Chinese medicinal preparation for external treating burn and scald |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1326546C (en) * | 2005-02-28 | 2007-07-18 | 张岚 | Pure Chinese medicinal preparation for external treating burn and scald |
Non-Patent Citations (1)
| Title |
|---|
| 曾冲.消肿止痛酊喷雾治疗烧烫伤.《河南中医药学刊》.1998,第13卷(第1期),第51-52页. * |
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