CN101658568A - Application of Chinese medicinal composition in preparing medicament for treating pulmonary heart disease - Google Patents
Application of Chinese medicinal composition in preparing medicament for treating pulmonary heart disease Download PDFInfo
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Abstract
The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating pulmonary heart disease. The medicament mainly comprises weeping forsythiae capsule, honeysuckle flower, indigowoad root, rhubarb, cablin potchouli herb, male fern rhizome, rhodiola rosea and the like, has the comprehensive regulation advantages of compound Chinese medicaments, organicallycombines the effects of eliminating diseases, relieving symptoms and regulating immunity, achieves multi-target therapy, and has obvious treatment effect on the pulmonary heart disease through verification of clinical experiments.
Description
Technical field
The present invention relates to the application of a kind of Chinese medicine composition in preparation treatment pulmonary heart disease medicine, belong to field of Chinese herbal.
Background technology
Pulmonary heart disease is called for short pulmonary heart disease, mainly is because acute pulmonary embolism sharply increases pulmonary vascular resistance, and causes acute expansion of right ventricle and depletion.Emergency pulmonary heart disease by the course of disease can be divided into acute cor pulmonale and chronic pulmonary heart disease, chronic person is comparatively common, mainly be because the pulmonary vascular resistance that chronic pulmonary, thoracopathy or lung vascular lesion cause increases, the right ventricle load is increased the weight of, right ventricular hypertrophy causes each heart disease of right heart failure at last.Its common cause of disease mainly contains chronic bronchitis, the concurrent chronic obstructive emphysema of bronchial asthma, accounts for 80-90%, is bronchiectasis, pulmonary tuberculosis, pneumosilicosis, chronic pulmonary interstitial fibrosis, chest deformity, pachynsis pleurae etc. secondly.This disease course of disease slower development, sings and symptoms progressively occurs, and breathing and circulatory function still can be compensatory in early days, but heart failure and respiratory failure then occur to late period.
Acute cor pulmonale is extremely rare in China, and its main diseases is obstructed the unexpected major part of pulmonary circulation because of being that the total tremulous pulse of lung is always done or big ramose thromboembolism, causes cardiac output to reduce, and causes right ventricle sharply expansion and acute right heart failure; The most common person of chronic pulmonary heart disease is the courageous and upright pulmonary heart disease of chronic hypoxia, claim obstructive emphysema heart disease again, be meant that the pulmonary vascular resistance that is caused by pulmonary's thorax or Pulmonic chronic pathological changes increases, cause pulmonary hypertension and right ventricular hypertrophy, companion or without a class heart disease of right heart failure.
Clinically, the pulmonary heart disease course of disease is made slow progress, can be divided into compensatory with lose compensatory two stages: 1, the patient has chronic cough, expectoration or asthma history the functional compensation phase, weak, dyspnea progressively occurs.2, function is lost the lung tissue infringement of compensatory phase and is seriously caused anoxia, carbon dioxide retention, can cause breathing and (or) heart failure: (1) respiratory failure anoxia mainly shows as cyanosis, cardiopalmus and uncomfortable in chest etc. in early days; hypoxemia and hypercapnia take place when pathological changes further develops, various spiritual neurological disorder symptoms can occur; Therefore (2) heart failure mostly occurs after acute respiratory infection, often is associated with respiratory failure, and the patient asthma, cardiopalmus, oliguria, cyanosis occur and increases the weight of, and upper abdomen distending pain, inappetence, feels sick even right heart failure symptom such as vomiting.
The Drug therapy of pulmonary heart disease mainly comprises single agent medication and drug combination, single agent medication nifedipine mainly commonly used, captopril, phentolamine, Ahylysantinfarctase-II, magnesia mixture and DOPA oxyphenisatin peace etc.; Drug combination comprises that mainly nifedipine adds Xinnao Shutong, and phentolamine adds dopamine, and phentolamine adds aminophylline, and phentolamine adds heparin, and dopamine adds Anisodamine, and dopamine adds magnesium sulfate etc.
The present invention is the improvement invention of carrying out on the basis of ZL03143211 patent, quotes in full the content of this patent document record at this.The application of unexposed this Chinese medicine composition of above-mentioned patent in preparation treatment sinusitis medicine.
Summary of the invention
The invention provides the application in a kind of Chinese medicine composition preparation treatment pulmonary heart disease medicine, this Chinese medicine composition is made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention is preferably:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
The weight part ratio of the crude drug of Chinese medicine composition of the present invention also is preferably:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
Chinese medicine composition of the present invention mainly is made up of Fructus Forsythiae, Flos Lonicerae, Radix Isatidis, Radix Et Rhizoma Rhei, Herba Pogostemonis, Rhizoma Dryopteris Crassirhizomatis, Radix Rhodiolae etc., the integrally-regulated advantage of performance herbal mixture, the combination of dispeling disease and evil, relief of symptoms, adjusting immunity, realize many target treatments, clinical experiment confirms that pulmonary heart disease is all had significant curative effect.
Chinese medicine of the present invention can be had the Chinese medicine of same or similar effect fruit to replace, and these medical materials all can be concocted according to " national Chinese medicine processing standard " or " Chinese medicine voluminous dictionary ".
The active component of Chinese medicine composition of the present invention is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
The dosage form of medicine of the present invention is capsule, tablet, powder, granule, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
Wherein capsule is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, promptly.
The preparation method of granule wherein is to be made by following steps:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
The preparation method of preferred granule is:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filter liquor that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds 95% ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol gets clear paste filtrate to there not being the alcohol flavor;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, be concentrated into and in the time of 60 ℃, measure relative density and be the thick paste of 1.25-1.35, standby;
(6) step (5) gained thick paste being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
The preparation method of other dosage forms of medicine of the present invention is: weighting raw materials in proportion, adopt conventional preparation method preparation, for example, the preparation technology of Fan Biting " pharmacy of Chinese materia medica " (Shanghai Science Press 1997 December the 1st edition) record makes the acceptable regular dosage form of pharmaceutics.
The specific embodiment
Following embodiment is used to illustrate the preparation of medicine of the present invention, but it can not constitute any restriction to scope of the present invention.
Embodiment 1
Prescription:
Fructus Forsythiae 255 gram Flos Loniceraes 255 gram Radix Isatidis 255 gram Radix Et Rhizoma Rhei 51 grams
Herba Pogostemonis 85 gram Rhizoma Dryopteris Crassirhizomatiss 255 gram Radix Rhodiolaes 85 gram Mentholums 7.5 grams
Herba Ephedrae 85 gram Semen Armeniacae Amarum (parched) 85 gram Herba Houttuyniae 255 gram Radix Glycyrrhizaes 85 grams
Gypsum Fibrosum 255 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder is added starch 142 grams, use 85% alcohol granulation;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, 1000 capsules of packing into, promptly.
Embodiment 2
Prescription:
Fructus Forsythiae 200 gram Flos Loniceraes 300 gram Radix Isatidis 200 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 60 gram Rhizoma Dryopteris Crassirhizomatiss 300 gram Radix Rhodiolaes 60 gram Mentholums 9 grams
Herba Ephedrae 60 gram Semen Armeniacae Amarums 100 gram Herba Houttuyniae 200 gram Radix Glycyrrhizaes 100 grams
Gypsum Fibrosum 200 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 5 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 6 times of amount ethanol extractions of 50% 2 times, 1 hour for the first time, 2.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder is added starch 151 grams, use 85% alcohol granulation;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, compacting gets 935 in flakes.
Embodiment 3
Prescription:
Fructus Forsythiae 300 gram Flos Loniceraes 200 gram Radix Isatidis 300 gram Radix Et Rhizoma Rhei 60 grams
Herba Pogostemonis 100 gram Rhizoma Dryopteris Crassirhizomatiss 200 gram Radix Rhodiolaes 60 gram Mentholums 5 grams
Herba Ephedrae 100 gram Semen Armeniacae Amarums 60 gram Herba Houttuyniae 300 gram Radix Glycyrrhizaes 60 grams
Gypsum Fibrosum 300 grams.
Preparation method:
(1) takes by weighing Chinese crude drug according to above-mentioned prescription, clean;
(2) Herba Pogostemonis is cataclasm, adds 8 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 10 times of amount ethanol extractions of 90% 2 times, 3 hours for the first time, 2.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 11 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation was placed 24 hours, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, spray drying, and the powder that gets dry extract, standby;
(6) with step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum are made pill according to a conventional method, get pill 905 balls.
Embodiment 4:
The crude drug prescription is:
Fructus Forsythiae 170g Flos Lonicerae 170g Herba Ephedrae (processing) 57g Semen Armeniacae Amarum (stir-fry) 57g
Gypsum Fibrosum 170g Radix Isatidis 170g Rhizoma Dryopteris Crassirhizomatis 170g Herba Houttuyniae 170g
Herba Pogostemonis 57g Radix Et Rhizoma Rhei 34g Radix Rhodiolae 57g Mentholum 5.0g
Radix Glycyrrhizae 57g
Preparation method:
(1) extraction process:
(1) take by weighing Chinese crude drug according to above-mentioned recipe quantity, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis adds 6 times of water gagings extraction volatile oil, carries oil time 4h, collects volatile oil, and oil yield is 0.33 ± 0.05%, and standby behind the extracting liquid filtering, residue discards;
(3) Fructus Forsythiae, Herba Ephedrae (processed), Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting liquid filtering, filtrate merges, and reclaims ethanol to there not being the alcohol flavor, and is standby;
(4) Flos Lonicerae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae, adding 9 times of water gagings decocts to boiling, add Semen Armeniacae Amarum (parched), decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting liquid filtering, filtrate merging adds the aqueous solution after step (2) Herba Pogostemonis is carried oil simultaneously, and being condensed into 60 ℃ of mensuration relative densities is the 1.10-1.15 clear paste, adds 95% ethanol, the limit edged stirs, to determining alcohol 70%, cold preservation was placed 24 hours, filtered, filtrate recycling ethanol is to there not being the alcohol flavor, merge with alcohol extract, be concentrated into and be condensed into 60 ℃ and measure relative densities and be the 1.25-1.35 thick paste, standby;
(2) preparation process:
(5) pharmaceutical formulation is: step (4) gained thick paste 335.5g Mentholum 5g
Step (2) gained patchouli oil 0.2ml Icing Sugar 342.5g dextrin 514.0g
(6) granulate: with Icing Sugar and dextrin mix homogeneously, make binding agent system soft material with thick paste, 14 eye mesh screens are granulated, 60-65 ℃ of oven dry, 10 eye mesh screen granulate;
(7) packing: it is an amount of to sift out fine powder, and Mentholum, Herba Pogostemonis Volatile oil are added an amount of ethanol, and dissolving sprays in the fine powder, mix homogeneously, and with the granule mix homogeneously, airtight half an hour, pack, that is, more than writing out a prescription can be made into granule 1000g.
Experimental example:
For confirming the curative effect of Drug therapy pulmonary heart disease of the present invention, use the capsule (to call medicine of the present invention in the following text) that makes by embodiment 1 method, carried out following clinical experimental study:
1 data and method
1.1 physical data
All cases are the Hebei Yi Ling hospital acute exacerbation of chronic pulmonary heart disease of being in hospital, and totally 100 examples are divided into treatment group and matched group at random, each 50 example.Male 40 examples are organized in treatment, women 10 examples, 69.7 years old mean age, average course of disease 14.5.Matched group man 42 examples, women 8 examples, 68.2 years old mean age, average course of disease 15.2.Two groups of sexes, age and courses of disease are there was no significant difference (P＞0.05) by statistics, has comparability.
1.2 case is selected inclusion criteria: meet the diagnostic criteria that national pulmonary heart disease meeting is formulated.
Exclusion standard: get rid of the heart, brain, liver, kidney disease and diabetes.
1.3 the Therapeutic Method matched group adopts oxygen therapy, infection, cough-relieving, eliminating phlegm and relieving asthma, improvement ventilation, diuresis, expansion blood vessel and the Supporting Therapy of suiting the medicine to the illness.The treatment group adds on the matched group basis uses medicine of the present invention, and 4/time, 3 times/day.Be 14 days two groups of courses of treatment.
1.4 observation index is observed the variation of two groups of patient treatments front and back arterial blood gas analysis.
1.5 curative effect determinate standard: 1. produce effects: under the rest state, cough with asthma, dyspnea disappear, and two lungs are done, moist sound disappears or obviously reduce, and partial pressure of oxygen recovers normal or rising 20mmHg; 2. effective: above-mentioned symptom, sign take a turn for the better partial pressure of oxygen rising 10-20mmHg; 2. invalid: state of an illness no change or increase the weight of before and after the treatment.
1.6 statistical procedures adopts the SPSS13.0 statistical software to carry out date processing, (x ± s) expression adopts the t check to measurement data, and enumeration data adopts x with mean ± standard deviation
2Check.
2 results
2.1 clinical efficacy more by statistics, treatment group patient total effective rate is apparently higher than matched group (P＜0.05).The results are shown in Table 1.
Table 1 liang group patient clinical efficacy is (%) relatively
Annotate: * and # be x relatively
2=5.26, P＜0.05.
2.2 blood gas analysis changes more by statistics before and after two groups of treatments, the treatment group is compared with matched group, and blood oxygen pressure obviously raises, and partial pressure of carbon dioxide obviously reduces (P＜0.05), pH value there was no significant difference (P＞0.05).The results are shown in Table 2.
Table 2 liang group patient blood gas analysis comparison (x ± s)
Annotate: * and # be P＜0.05 relatively.
3 conclusions
This research is on the basis of doctor trained in Western medicine conventional therapy, add Drug therapy of the present invention, all be better than simple western medical treatment at aspects such as improving clinical efficacy, reduction partial pressure of carbon dioxide and rising blood oxygen pressure, confirm that fully medicine of the present invention has significant clinical efficacy to pulmonary heart disease.
Claims (10)
1, the application of a kind of Chinese medicine composition in preparation treatment pulmonary heart disease medicine is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200-300 Flos Lonicerae 200-300 Radix Isatidis 200-300 Radix Et Rhizoma Rhei 40-60
Herba Pogostemonis 60-100 Rhizoma Dryopteris Crassirhizomatis 200-300 Radix Rhodiolae 60-100 Mentholum 5-9
Herba Ephedrae 60-100 Semen Armeniacae Amarum 60-100 Herba Houttuyniae 200-300 Radix Glycyrrhizae 60-100
Gypsum Fibrosum 200-300.
2, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 200 Flos Loniceraes 300 Radix Isatidis 200 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 60
Rhizoma Dryopteris Crassirhizomatis 300 Radix Rhodiolaes 60 Mentholums 9 Herba Ephedraes 60 Semen Armeniacae Amarums 100
Herba Houttuyniae 200 Radix Glycyrrhizaes 100 Gypsum Fibrosum 200.
3, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 300 Flos Loniceraes 200 Radix Isatidis 300 Radix Et Rhizoma Rhei 60 Herba Pogostemonis 100
Rhizoma Dryopteris Crassirhizomatis 200 Radix Rhodiolaes 60 Mentholums 5 Herba Ephedraes 100 Semen Armeniacae Amarums 60
Herba Houttuyniae 300 Radix Glycyrrhizaes 60 Gypsum Fibrosum 300.
4, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 278 Flos Loniceraes 294 Radix Isatidis 285 Radix Et Rhizoma Rhei 55 Herba Pogostemonis 95
Rhizoma Dryopteris Crassirhizomatis 290 Radix Rhodiolaes 287 Mentholums 8.5 Herba Ephedraes 88 Semen Armeniacae Amarums 80
Herba Houttuyniae 284 Radix Glycyrrhizaes 95 Gypsum Fibrosum 277.
5, application according to claim 1 is characterized in that being made by following bulk drugs:
Fructus Forsythiae 255 Flos Loniceraes 255 Radix Isatidis 255 Radix Et Rhizoma Rhei 51 Herba Pogostemonis 85
Rhizoma Dryopteris Crassirhizomatis 255 Radix Rhodiolaes 85 Mentholums 7.5 Herba Ephedraes 85 Semen Armeniacae Amarum (parched) 85
Herba Houttuyniae 255 Radix Glycyrrhizaes 85 Gypsum Fibrosum 255.
6, according to each described application of claim 1-5, it is characterized in that the active component of described Chinese medicine composition is made by following steps:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
Step (5) gained dried cream powder, step (2) gained volatile oil and Mentholum constitute the active component of this Chinese medicine composition jointly.
7,, it is characterized in that described pharmaceutical dosage form is capsule, tablet, powder, granule, oral liquid, soft capsule, pill, tincture, syrup, suppository, gel, spray or injection according to each described application of claim 1-5.
8,, it is characterized in that it is to be made by following steps according to the preparation method of the described medicine capsule of claim 7:
(1) takes by weighing Chinese crude drug according to the crude drug part by weight, clean;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour,, extracting solution merges filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained clear paste and step (3) gained alcohol extract merge, and being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing incapsulates, promptly.
9,, it is characterized in that it being to make by following steps according to the preparation method of the described medicinal granule of claim 7:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 5-8 times of water gaging and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei are doubly measured the ethanol extraction 2 times of 50-90% with 6-10, and each 1-3 hour, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 7-11 times of water gaging and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, each 0.5-2.5 hour, extracting solution merged filtration, the filtrate that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed in the time of 60 ℃ and measuring relative density is the clear paste of 1.10-1.15, adds ethanol, reconcile to determining alcohol be 70%, cold preservation is placed, filter, recovery ethanol is not to there being the alcohol flavor, and it is standby to get clear paste;
(5) step (4) gained gained clear paste and step (3) gained alcohol extract are merged, being concentrated into and measuring relative density in the time of 60 ℃ is the clear paste of 1.15-1.20, drying, and the powder that gets dry extract, standby;
(6) step (5) gained dried cream powder being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
10,, it is characterized in that it being to make by following steps according to the preparation method of the described medicinal granule of claim 9:
(1) take by weighing Chinese crude drug according to the crude drug part by weight, clean, cataclasm as one sees fit;
(2) Herba Pogostemonis is cataclasm, adds 6 times of water gagings and extracts volatile oil, carries the 4 hours time of oil, collects volatile oil, and is standby; Behind the extracting liquid filtering, residue discards, filtrate for later use;
(3) Fructus Forsythiae, Herba Ephedrae, Herba Houttuyniae, Radix Et Rhizoma Rhei, with 8 times of amount ethanol extractions of 70% 2 times, 2 hours for the first time, 1.5 hours for the second time, extracting solution merged and filters, and reclaims ethanol, filtrate for later use;
(4) Flos Lonicerae, Gypsum Fibrosum, Radix Isatidis, Rhizoma Dryopteris Crassirhizomatis, Radix Glycyrrhizae, Radix Rhodiolae add 9 times of water gagings and decoct to boiling, and add Semen Armeniacae Amarum, decoct 2 times, 1.5 hours for the first time, 1 hour for the second time, extracting solution merged filtration, the filter liquor that gained filtrate and step (2) Herba Pogostemonis is carried behind the oil merges, being condensed into and measuring relative density in the time of 60 ℃ is the clear paste of 1.10-1.15, adds 95% ethanol, and being adjusted to determining alcohol is 70%, cold preservation is placed, filter, recovery ethanol gets clear paste filtrate to there not being the alcohol flavor;
(5) step (4) gained clear paste filtrate and step (3) gained alcohol extract are merged, be concentrated into and in the time of 60 ℃, measure relative density and be the thick paste of 1.25-1.35, standby;
(6) step (5) gained thick paste being added suitable acceptable accessories granulates;
(7) Mentholum, step (2) gained volatile oil are added dissolve with ethanol, spray into step (6) gained granule, airtight, mixing, pack, promptly.
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