CN101653460A - Formulation and production technology for propolis soft capsules - Google Patents
Formulation and production technology for propolis soft capsules Download PDFInfo
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- CN101653460A CN101653460A CN200810212431A CN200810212431A CN101653460A CN 101653460 A CN101653460 A CN 101653460A CN 200810212431 A CN200810212431 A CN 200810212431A CN 200810212431 A CN200810212431 A CN 200810212431A CN 101653460 A CN101653460 A CN 101653460A
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Abstract
The invention relates to a formulation and production technology for propolis soft capsules. The formulation of the propolis soft capsules mainly comprise the following raw material in percentage by weight: 1 percent to 50 percent of propolis extract, 20 percent to 90 percent of seed oil, 0.5 percent to 5 percent of VE oil, 1 percent to 20 percent of royal jelly freeze-dried powder and 1 percent to 5 percent of emulsifier. The preparation method thereof comprises the following steps: smashing the propolis extract at a low temperature; adding the seed oil to the smashed propolis extract; addingthe emulsifier to the propolis extract; heating the propolis extract to 80 DEG C to 90 DEG C to dissolve the propolis extract sufficiently; lowering the temperature to 35 DEG C to 40 DEG C; adding the royal jelly freeze-dried powder and the VE oil to the propolis extract; stirring the mixture sufficiently; and filling the soft capsule by a conventional process after homogenising (40 MPa to 50 MPa, less than or equal to 40 DEG C) or ultra-fine smashing ( less than or equal to 40 DEG C, greater than or equal to 200 meshes).
Description
Technical field
The present invention relates to a kind of prescription and production technology of bee glue soft capsule.Belong to field of health care food.This product is wrapped in propolis extract and other auxiliary element in the soft capsule material, and this soft capsule dosage form is convenient to people and is taken, and digests and assimilates easily, has avoided the pungent mouthfeel of propolis and gastrointestinal is stimulated.Add Lac regis apis lyophilized powder and vitamin E oil simultaneously, improve oxidation resistance, strengthened the effect of propolis, strengthen health care.
Background technology
Along with people go deep into the understanding of bee product, its health care and the effect of treatment disease receive much attention.Propolis is subjected to the generally favor of consumer with its unique biological effect and effect.The propolis resin that to be Apis gather from positions such as the tree bud of plant, barks mixes the secretions of bodies of gland such as lingual gland with Apis, wax gland again, a kind of colloid substance that is transformed through Apis processing.The fundamental component of propolis is a total flavones, and China's Ministry of Public Health has been ratified the effective component that total flavones is the propolis health food.Total flavones is the needed by human nutrient, can not synthesize in the human body, can only absorb from diet, is the vital excited state active substance of a class.Therefore, flavone can improve blood circulation state and hematopoietic function, improves elasticity of blood vessels and permeability, and vasodilator is removed blood vessel and accumulated thing, purifies the blood, and blood viscosity lowering etc. have obvious treatment and preventive effect to cardiovascular and cerebrovascular disease.In addition, contain the aminoacid and the vitamin B of trace in the propolis, abundant mineral and trace element, multiple organic acid and terpenoid.
Bee glue product mainly contains propolis liquid, propolis hard capsule, bee glue soft capsule.Wherein, soft capsule is the dosage form that liked by consumer, and it has not only avoided the shortcoming of propolis liquid mouthfeel difference, digest and assimilate than hard capsule is easier simultaneously, and therefore be the direction of bee glue product development.Present soft capsule prescription on the market, how with Polyethylene Glycol as emulsifying agent, but Polyethylene Glycol does not obtain the permission of state food additive as yet, and easily contains ethylene glycol, diethylene glycol, formaldehyde etc., its safety has to be assessed.Propolis can not be water-soluble, in ethanol, can not dissolve fully, and, if also will cause the glue shell dehydration hardening of soft capsule as solvent, be inconvenient to use with ethanol.
The present invention does not use Polyethylene Glycol, does not use ethanol yet, but adopts the emulsified component of conventional material such as vegetable oil, Cera Flava as propolis, after homogenizing, milling treatment of colloid or micropowder are handled, it disperses fully, and phenomenon such as layering can not occur, separate out is fit to the production of soft capsule fully.And in the shelf-life, finished product soft capsule in stable condition can not occur chapping, phenomenon such as variable color.
Lac regis apis lyophilized powder used in the present invention, be with fresh royal jelly at-20 ℃--form through vacuum, drying, pulverizing supervisor are refining under 50 ℃ the low temperature.It is in stable suspended state in this fills a prescription described feed liquid, not only increased emulsifying effectiveness, and the efficacy effect of this prescription is had significant potentiation.
Vitamin E used in the present invention can be dissolved in the vegetable oil fully, and the antioxidation of this prescription is had significant potentiation, and multiple physiological hygiene function also can be provided simultaneously.Summary of the invention the purpose of this invention is to provide a kind of prescription and production technology of novel propolis soft capsule, and its batching mainly contains: propolis extractum, and vegetable oil, VE oil, Lac regis apis lyophilized powder and emulsifying agent, each composition account for percentage by weight and are:
Propolis extractum: 1%～50%
Vegetable oil: 20%～90%
VE oil: 0.5%～5%
Lac regis apis lyophilized powder: 1%～20%
Emulsifying agent: 1%～5%
Propolis extractum of the present invention is that thick propolis refluxes in 95% ethanol and concentrates the extractum form.
Lac regis apis lyophilized powder of the present invention, be fresh royal jelly at-20 ℃--under 50 ℃ the cryogenic conditions, the buff powder that forms through lyophilization.
The vegetable oil of indication of the present invention refers to the edible plants oil that extracts from single plant, as Oleum Brassicae campestris, soybean oil, Petiolus Trachycarpi oil, Semen arachidis hypogaeae wet goods, or the mixture of the single vegetable oil of several edibles.
The used vitamin E oil of the present invention is the thick liquid of little yellow or yellow transparent; Odorless almost; It is dark to meet photochromic gradual change.Easily molten in dehydrated alcohol, acetone, ether or petroleum ether, insoluble in water.
The used emulsifying agent of the present invention is the additive that uses for the needs of preparation, as Cera Flava, and molecule distillating monoglyceride, one or more in single caprylin etc.
The technology of indication of the present invention is: at low temperatures propolis extractum is pulverized, added in the vegetable oil, add emulsifying agent, be heated to 80 ℃-90 ℃, make it fully emulsified, be cooled to 35 ℃-40 ℃, add Lac regis apis lyophilized powder and VE oil, fully stir, through homogenizing (40MPa-50MPa ,≤40 ℃), or (≤40 ℃ of micronizing, 〉=200 orders) after, carry out the soft capsule fill according to common process.
Concrete embodiment
Embodiment 1:
Propolis extractum: 33% Lac regis apis lyophilized powder: 5%
Soybean oil: 58% Cera Flava: 3.5%
VE oil: 0.5%
Production technology: soybean oil and Cera Flava are mixed, are heated to 85 ℃ while stirring, with propolis 4 ℃ of pulverizing, the soybean oil that adds above-mentioned heating, make propolis fully emulsified, be cooled to 40 ℃ then, add Lac regis apis lyophilized powder, VE oil, stir, utilize homogenizer, the homogenizing parameter: pressure 45MPa, 30 ℃ of temperature, homogenizing is finished, and carries out the production of soft capsule according to common process.
Embodiment 2:
Propolis extractum: 35% Lac regis apis lyophilized powder: 5%
Salad oil: 55% molecular distillation monoresin: 4%
VE oil: 1%
Production technology: with propolis 0 ℃ of-4 ℃ of pulverizing, salad oil and molecular distillation are gone alone the ester mixing, add the propolis of pulverizing, be heated to 80 ℃ while stirring, after the propolis emulsifying fully, naturally cool to 40 ℃, add Lac regis apis lyophilized powder, VE oil, stir, utilize (≤40 ℃ of super micron mill, 〉=200 orders) after pulverizing is finished, carry out the production of soft capsule according to common process.
Embodiment 3:
Propolis extractum: 33.33% Lac regis apis lyophilized powder: 5%
Oleum Brassicae campestris: 57.17% emulsifying agent: 3.5%
VE oil: 1%
Production technology: the technology according to above-mentioned embodiment 1 is carried out.
Embodiment 4:
Propolis extractum: 38% Lac regis apis lyophilized powder: 6%
Oleum Arachidis hypogaeae semen: 50% emulsifying agent: 5%
VE oil: 1%
Production technology: the technology according to above-mentioned embodiment 2 is carried out.
Claims (5)
1, the prescription of a kind of bee glue soft capsule of the present invention and production technology, its prescription contains: propolis extractum, vegetable oil, VE oil, Lac regis apis lyophilized powder, emulsifying agent, each composition account for percentage by weight and are:
Propolis extractum: 1%～50% vegetable oil: 20%～90%
VE oil: 0.5%～5% Lac regis apis lyophilized powder: 1%～20%
Emulsifying agent: 1%～5%.
2, the prescription of a kind of bee glue soft capsule according to claim 1 and production technology is characterized in that: the propolis extractum of indication of the present invention is that thick propolis refluxes in 95% ethanol and concentrates the extractum form.
3, the prescription of a kind of bee glue soft capsule according to claim 1 and production technology is characterized in that: the vegetable oil of indication of the present invention refers to the edible plants oil that extracts or the mixture of the single vegetable oil of several edibles from single plant.
4,, the prescription and the production technology of a kind of bee glue soft capsule according to claim 1, it is characterized in that: emulsifying agent is the additive that uses for the needs of preparation, is Cera Flava, molecule distillating monoglyceride, one or more in single caprylin.
5, the prescription of a kind of bee glue soft capsule according to claim 1 and production technology, its production technology is: at low temperatures propolis extractum is pulverized, added vegetable oil, add emulsifying agent again, be heated to 80 ℃-90 ℃, make it fully emulsified, be cooled to 35 ℃-40 ℃, add Lac regis apis lyophilized powder and VE oil, fully stir, through homogenizing (40MPa-50MPa, ≤ 40 ℃), or after the micronizing (≤40 ℃, 〉=200 orders), carry out the soft capsule fill according to common process and produce.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810212431A CN101653460A (en) | 2008-08-22 | 2008-08-22 | Formulation and production technology for propolis soft capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810212431A CN101653460A (en) | 2008-08-22 | 2008-08-22 | Formulation and production technology for propolis soft capsules |
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| Publication Number | Publication Date |
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| CN101653460A true CN101653460A (en) | 2010-02-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810212431A Pending CN101653460A (en) | 2008-08-22 | 2008-08-22 | Formulation and production technology for propolis soft capsules |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843308A (en) * | 2010-06-07 | 2010-09-29 | 杭州天厨蜜源保健品有限公司 | Propolis soft capsule and preparation method thereof |
| CN101878870A (en) * | 2010-06-22 | 2010-11-10 | 江西汪氏蜜蜂园有限公司 | Preparation method of propolis all-components soft capsule |
| CN101991034A (en) * | 2010-11-11 | 2011-03-30 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN102133237A (en) * | 2011-03-31 | 2011-07-27 | 射阳县庆缘康蜂产品厂 | Propolis flavone soft capsule and preparation method thereof |
| CN102366098A (en) * | 2011-10-25 | 2012-03-07 | 江苏江大源生态生物科技有限公司 | Supercritical propolis soft capsules and preparation method thereof |
| CN103300275A (en) * | 2013-06-24 | 2013-09-18 | 北京知蜂堂蜂产品有限公司 | Royal jelly and preparation method thereof |
| CN104706737A (en) * | 2015-03-20 | 2015-06-17 | 王跃进 | Preparation method for royal jelly soft shell capsule capable of promoting sleep |
| CN104920933A (en) * | 2015-06-09 | 2015-09-23 | 江苏日高蜂产品有限公司 | Propolis soft capsules and preparation method thereof |
| CN104970280A (en) * | 2015-06-24 | 2015-10-14 | 山东华瀚食品有限公司 | Dried propolis powder and preparation method thereof |
| CN107224445A (en) * | 2017-05-08 | 2017-10-03 | 西北大学 | Propolis active component and its compound product and application |
| CN112715933A (en) * | 2020-12-29 | 2021-04-30 | 江苏艾兰得营养品有限公司 | Royal jelly capsule and preparation method thereof |
-
2008
- 2008-08-22 CN CN200810212431A patent/CN101653460A/en active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101843308A (en) * | 2010-06-07 | 2010-09-29 | 杭州天厨蜜源保健品有限公司 | Propolis soft capsule and preparation method thereof |
| CN101843308B (en) * | 2010-06-07 | 2012-12-12 | 杭州天厨蜜源保健品有限公司 | Propolis soft capsule and preparation method thereof |
| CN101878870A (en) * | 2010-06-22 | 2010-11-10 | 江西汪氏蜜蜂园有限公司 | Preparation method of propolis all-components soft capsule |
| CN101991034B (en) * | 2010-11-11 | 2012-11-14 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN101991034A (en) * | 2010-11-11 | 2011-03-30 | 周云川 | High-efficiency wall breaking propolis soft capsule |
| CN102133237A (en) * | 2011-03-31 | 2011-07-27 | 射阳县庆缘康蜂产品厂 | Propolis flavone soft capsule and preparation method thereof |
| CN102366098A (en) * | 2011-10-25 | 2012-03-07 | 江苏江大源生态生物科技有限公司 | Supercritical propolis soft capsules and preparation method thereof |
| CN103300275A (en) * | 2013-06-24 | 2013-09-18 | 北京知蜂堂蜂产品有限公司 | Royal jelly and preparation method thereof |
| CN103300275B (en) * | 2013-06-24 | 2015-03-25 | 北京知蜂堂蜂产品有限公司 | Royal jelly and preparation method thereof |
| CN104706737A (en) * | 2015-03-20 | 2015-06-17 | 王跃进 | Preparation method for royal jelly soft shell capsule capable of promoting sleep |
| CN104920933A (en) * | 2015-06-09 | 2015-09-23 | 江苏日高蜂产品有限公司 | Propolis soft capsules and preparation method thereof |
| CN104970280A (en) * | 2015-06-24 | 2015-10-14 | 山东华瀚食品有限公司 | Dried propolis powder and preparation method thereof |
| CN107224445A (en) * | 2017-05-08 | 2017-10-03 | 西北大学 | Propolis active component and its compound product and application |
| CN107224445B (en) * | 2017-05-08 | 2020-05-15 | 西北大学 | Propolis effective part and compound product and application thereof |
| CN112715933A (en) * | 2020-12-29 | 2021-04-30 | 江苏艾兰得营养品有限公司 | Royal jelly capsule and preparation method thereof |
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Application publication date: 20100224 |