CN101648004B - Medicinal composition for treating eye diseases and application thereof - Google Patents
Medicinal composition for treating eye diseases and application thereof Download PDFInfo
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Abstract
The invention discloses a medicinal composition for treating syndrome in front of screens, visual fatigue and dry eye syndrome and application thereof, and belongs to the field of Chinese medicament. The raw material medicament of effective components of the medicinal composition is collagen which can be combined with effective components of the Chinese medicament to form various eye preparations. The technical scheme creatively applies the collagen in the eye preparations so as to enlarge the application range of the collagen and achieve remarkable effect in the aspect of treating the syndrome in front of screens, the visual fatigue and the dry eye syndrome.
Description
Technical field
The present invention relates to a kind of medical composition and its use that is used for the treatment of front screen syndrom, asthenopia, xerophthalmia, belong to the field of Chinese medicines.
Background technology
In present communication society, the video display terminal (vdt)s such as computer, television set, game machine have been penetrated into each part of our daily life, the thing followed is that front screen syndrom, asthenopia, patients with dry eye are more and more, and has become a class social problem.Asthenopia is the common a kind of disease of present ophthalmology, and patient's symptom is varied, and common are near work can not be lasting, go out to lose face and eye socket around pain, blurred vision, eyes dry and astringent, shed tears etc., the severe patient headache, feel sick, dizzy.It is not disease independently, but the one group of fatigue syndrome that causes due to a variety of causes.Front screen syndrom refers to that point of fixation frequently moves owing to watching for a long time fluorescent screen attentively, film flicker, and keep for a long time a kind of operation posture, patient often to feel headache, blurred vision, ocular pain and dry and astringent.In present communication society, the video display terminal (vdt)s such as computer, television set, game machine have been penetrated into each part of our daily life, and have become a class social problem, more and more cause people's concern.Xerophthalmia is one of common eye surface diseases, refers to and ocular surface injury unstable due to the abnormal or tear film that tear hydrodynamics causes extremely of the quality and quantity of tear, thereby causes a class disease of ophthalmic uncomfortable symptom.Its symptom is usually expressed as sensation of dryness, foreign body sensation, burn feeling, gargalesthesia, blurred vision, furious, corneal contact lens does not tolerate etc.Front screen syndrom, asthenopia, xerophthalmia have common symptom: blurred vision, eyes are dry and astringent and pain etc.
Collagen protein is to contain peptide matters by the skin of animal, bone or heel string through what hydrolysis or mode of action made, to form the important protein of animal connective tissue, connective tissue is except containing 60～70% moisture, collagen protein has accounted for approximately 20～30%, be the extracellular matrix components that body weight for humans is wanted, have good fibre-forming performance, anthemorrhagic performance, cell-cell interaction performance, promote the biological characteristics that wound healing and tissue repair etc. are good; To cell, tissue and even organ exercises normal function and reparation has significant impact to wound, the bootable epithelial cell defective region of moving into, lubricate when cell migration; Be the synthetic substrate of utilizing of regenerative cell, the AC effect is arranged simultaneously, strengthen the regenerative cell adhesive attraction; Collagen between the filling regenerative cell can reduce the auxocyte contact inhibition.As desirable Tissue Engineering Biomaterials, collagen protein is applied in cosmetics and hemostasis class medical apparatus and instruments always.New research is found, peptide constituents in collagen protein has the nutrition of better increase eye, increases the wetting function of ocular surface, can alleviate blurred vision, eyes are dry and astringent and the multiple efficacies such as pain, have vast potential for future development in treatment front screen syndrom, asthenopia, xerophthalmia.
In the patent application of collagen eye drops in (application number CN200510098424.7) and composite collagen eye drops patent application in (application number CN200510098425.1), the not clear and definite effective component group of its applied collagen protein, but according to the preparation method of collagen protein in patent as can be known, on patent the collagen protein of indication actual be collagen.(will be very large. collagen and collagen protein. Beijing: Chemical Industry Press, 2006.3, clearly defined collagen and collagen protein in this book, and the preparation method of collagen, collagen protein is also had detailed description).As seen collagen protein not at ophthalmology, is particularly treated in front screen syndrom, asthenopia, xerophthalmia and is used.
In view of good lubrication, the Nutrition of collagen protein, be necessary collagen protein is developed to the medicine for the treatment of front screen syndrom, asthenopia, xerophthalmia.
Summary of the invention
The first purpose of the present invention is to provide a kind of pharmaceutical composition for the treatment of front screen syndrom, asthenopia, xerophthalmia.
The second purpose is to provide the application of this pharmaceutical composition aspect treatment front screen syndrom, asthenopia, xerophthalmia.
Specifically:
The invention provides a kind of pharmaceutical composition for the treatment of front screen syndrom, asthenopia, xerophthalmia, contain collagen protein in this pharmaceutical composition effective ingredient.
Further, the crude drug of this pharmaceutical composition effective ingredient is any or the combination more than two kinds in collagen protein and following Chinese medicine: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Carthami, Caulis Spatholobi, Herba Leonuri, Radix Achyranthis Bidentatae, Hirudo, Eupolyphaga Seu Steleophaga, Semen Persicae, Semen Cassiae, Rhizoma Curcumae, Radix Glycyrrhizae, Semen Celosiae, Flos Buddlejae, Cortex Moutan, Semen Oroxyli, Spica Prunellae, Scorpio, Scolopendra, Concha Haliotidis, Calamina, artificial Moschus, Margarita, Margarita layer powder, Borneolum Syntheticum, Mentholum.Collagen protein in this pharmaceutical composition effective ingredient can replace with collagen, or replaces with the mixture of collagen and collagen protein.
In pharmaceutical composition effective ingredient of the present invention, the ratio of collagen protein and Chinese medicine ingredients is 1: 0.3～1: 10.Wherein Effective Component of Chinese Medicine mean Chinese crude drug after extracting resulting Chinese medicine extract and (or) the former powder of medical material, refer in final products both ratios of solid content weight with the part by weight of collagen protein.Through preferred, in the pharmaceutical composition effective ingredient, the ratio of collagen protein and Chinese medicine ingredients is 1: 0.1～1: 30, and further in the preferred pharmaceutical compositions effective ingredient, the ratio of collagen protein and Chinese medicine ingredients is 1: 1～1: 10.
Above-mentioned selected ingredients can be used as medicine by former powder in preparation medicine process of the present invention, and physicochemical property that also can be exclusive according to effective ingredient selects suitable method to extract, and is refining, obtains corresponding extract and feeds intake.Can pass through to extract obtaining the extracting solution application as medical materials such as Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Notoginseng, the Radix Paeoniae Alba, Radix Paeoniae Rubra, Flos Carthami, Caulis Spatholobi, Herba Leonuri, Radix Achyranthis Bidentatae, Hirudo, Eupolyphaga Seu Steleophaga, Semen Persicae, Semen Cassiae, Rhizoma Curcumae, Radix Glycyrrhizae, Semen Celosiae, Flos Buddlejae, Cortex Moutan, Semen Oroxyli, Spica Prunellae, Scorpio, Scolopendra, Concha Haliotidis, Calamina, Margarita, Margarita layer powder, and the medical materials such as artificial Moschus, Borneolum Syntheticum, Mentholum can porphyrize or the rear directly application of dissolving.
As everyone knows, collagen protein is the important component part of animal connective tissue, account for 20～30%, so the present invention's collagen protein used is mainly by Raw material processing gained such as gelatin, Colla Corii Asini, new Colla Corii Asini, Corii Sus domestica, Corii Bovis seu Bubali, Os Sus domestica, Os Bovis seu Bubali, pig heel string or cattle heel strings.Above-mentioned raw materials obtains collagen after washing, remove impurity, acidolysis, collagen refers to the spirality fiber shape protein that twisted into by three peptide chains, is to form the important protein of animal connective tissue, and its relative molecular weight is 250～300kD, has triple-helix structure; Collagen further is hydrolyzed to get gelatin, and its relative molecular weight is 100～200kD, and triple-helix structure is destroyed; Collagen protein is the further enzymatic hydrolysate of gelatin, and its relative molecular weight is below 100kD, and wherein the overwhelming majority exists with the form of collagen peptide, and relative molecular weight is below 10kD.Collagen protein can also be directly from the raw materials such as gelatin, Colla Corii Asini, new Colla Corii Asini enzymolysis obtain.The relative molecular weight of collagen and gelatin is large, poorly water-soluble, and viscosity is high, and mechanical strength is high, and the relative molecular weight of collagen protein is less, and contained collagen peptide is more, and water solublity is strong, is easy to be absorbed by the body.
For the characteristics of ophthalmic remedy, in the present invention collagen protein used be molecular weight not higher than the part of 100kD, adopt after preferred molecular weight not higher than the part of 10kD, more preferably molecular weight is not higher than the part of 5kD.
The present invention's collagen protein main preparation methods used is: gets the collagen protein raw material, cleans, except impurity such as degrease, epidermis, residual meat, adopt acid solution to carry out extract at low temperature, and brine wash, the dialysis remove impurity, enzyme-added enzymolysis is further purified, and get final product.
or rather, the primary raw material of the present invention's collagen protein used derives from gelatin, Colla Corii Asini, new Colla Corii Asini, Corii Sus domestica, Corii Bovis seu Bubali, Os Sus domestica, Os Bovis seu Bubali, any one or a few during pig heel string or cattle are followed makes through enzymatic isolation method, and its relative molecular weight is preferably below 100kD, and described enzyme solution can be trypsin, pancreatin, neutral protease, alkaline protease, bromelain, any one single enzyme enzymolysis in ficin or papain can be also pepsin, trypsin, pancreatin, neutral protease, alkaline protease, bromelain, the combination enzymolysis of any several enzymes in ficin or papain, can also be to copy human body to digest and assimilate the bionic enzyme solution of process fully (namely at first to adopt the pepsin enzymatic isolation method of simulation human stomach's digestion process and physical and chemical parameter, then simulate human body intestinal canal and digest and assimilate the pancreas of process and physical and chemical parameter (albumen) enzyme enzymatic isolation method, thereby obtain to supply the directly low molecule oligopeptide material of absorption of human body).
In the preparation technology of above-mentioned collagen protein or collagen, acid used is any one or a few in tartaric acid, malic acid, acetic acid, citric acid, glycine or hydrochloric acid.
Pharmaceutical composition of the present invention mainly adopts the method for being prepared as follows to make:
A, get selected Chinese crude drug, pulverize, adopt the method for water extraction/alcohol extraction/first alcohol extraction water extraction/first water extraction alcohol extraction more again/stay powder/directly dissolving/extract volatile oil to make drug extract;
B, get the collagen solution or the fine powder that make, add the said medicine extract, add suitable ophthalmology pharmaceutic adjuvant, make required dosage form according to the pharmaceutics routine techniques, as eye drop, gel for eye use, instant gel for eye, eye ointment, eye patch, eye with ophthalmic preparations such as powder and membrane.
In addition, for improving the preparation curative effect, better bring into play the combination of Chinese medicine and collagen protein, pharmaceutical composition of the present invention can add the Aloe gel with lubrication, can also add to have the material that increases stickiness, lubricates and extend the drug release time effect, as: Aloe gel, hypromellose, carboxymethyl cellulose, hyaluronate sodium, trehalose, polyvinyl alcohol, poly-interior olefin(e) acid, carbomer, polyvinylpyrrolidone, chitosan etc.
Beneficial effect
As stating in above-mentioned summary of the invention, the present invention takes full advantage of nutrition, the lubrication of collagen protein, and, sufferings dry and astringent for the eyes of alleviating front screen syndrom, asthenopia, patients with dry eye, the symptom such as scorching hot, tired play good therapeutical effect.
The specific embodiment
Below further illustrate the present invention by specific embodiment, but following examples only are used for explanation the present invention and to not restriction of the present invention.
Embodiment one:
Prescription: collagen protein extracting solution 300ml (containing collagen protein 3.0g)
Method for making: get hyaluronate sodium 0.5g, add water for injection 600ml profit to open 24 hours, add collagen liquid 300ml, boric acid 12g, Borax 0.6g, ethyl hydroxybenzoate 0.8g, stir to clarify, be heated to 70 ℃, filter, inject water to 1000g, cross microporous filter membrane (0.22 μ m), aseptic subpackaged, and get final product.(annotate: collagen protein used be gelatin through pepsin and pancreatin bionic enzymatic, then through 5kD the ultrafilter membrane ultrafiltration obtain)
Embodiment two:
Prescription: collagen extraction liquid 100ml (containing collagen 30mg) collagen protein extracting solution 200ml (containing collagen protein 2.0g)
Method for making: get water for injection 1600ml, add gellan gum, stir, put in boiling water bath, stir to clarify, add boric acid 24g, Borax 1.2g, ethyl hydroxybenzoate 1.2g, be heated to 70 ℃, stir to clarify, filter, add collagen extraction liquid, collagen protein extracting solution under stirring, inject water to 2000g, cross microporous filter membrane (0.22 μ m), aseptic subpackaged, and get final product.(annotate: collagen protein used be Corii Sus domestica through neutral protease enzymolysis, then through 10kD the ultrafilter membrane ultrafiltration obtain, collagen adopts acetic acid solution to extract take Corii Bovis seu Bubali as raw material, makes through the pepsin enzymolysis, relative molecular weight is at 250～285kD.)
Embodiment three:
Prescription: Radix Paeoniae Rubra 500g aloe gel 20:1 g Mentholum 0.5g
Collagen protein extracting solution 200ml (containing collagen protein 2g)
method for making: get Radix Paeoniae Rubra, add 8 times of water gagings and decoct twice, each 2 hours, filter merging filtrate, concentrating under reduced pressure, adding ethanol makes and contains alcohol amount and reach 70%, hold over night is got the supernatant decompression recycling ethanol, AB-8 macroporous adsorptive resins on remaining water liquid, respectively with water, 50% ethanol elution, collect 50% ethanol elution, decompression recycling ethanol is to distinguishing the flavor of without alcohol, and water liquid is standby, separately getting phenoxyethanol joins in the water for injection that 1000ml has been heated to approximately 80 ℃, stir evenly, add while hot boric acid 24g, Borax 1.2g, be stirred to dissolve, let cool, join in the Radix Paeoniae Rubra extracting solution, stir evenly, slowly add Aloe gel, the Mentholum of dissolve with ethanol, continue to be stirred to dissolving fully, add the collagen protein extracting solution, and inject water to 2000ml, crossing microporous filter membrane (0.22m) filters, filtrate is heated to 50 ℃ again, add while hot hypromellose (50000～70000mpas), be stirred to room temperature, inject water to 2000g, stir evenly, form uniform gel, filter (0.80 μ m), aseptic subpackaged, and get final product.(annotate: collagen protein used be Corii Sus domestica and heel string through pepsin and papain enzymolysis, then through 100kD the ultrafilter membrane ultrafiltration obtain)
Embodiment four:
Prescription: Margarita liquid 60ml Mentholum 0.5g collagen protein 1.5g
Method for making: get Margarita powder, add 4 times of amount 10% sulfuric acid solutions, heated 2 hours, filter, filtrate adds calcium oxide and transfers to neutrality, filters, and gets Margarita liquid (contain total protein concentration and be not less than 1mg/ml); Get gellan gum 8g and boric acid, Borax adds in water for injection 1800ml, heated and boiled is cooled to 80 ℃, add Margarita liquid 60ml, be cooled to while stirring 60 ℃, separately Mentholum 0.5g, ethyl hydroxybenzoate 1g are dissolved in ethanol, be added dropwise to while stirring in above solution, add again collagen protein, be stirred to dissolve, and inject water to 2000ml, stir more than 30 minutes, cross microporous filter membrane (0.22 μ m), aseptic subpackaged, and get final product.(annotate: collagen protein used be Os Sus domestica and pig heel string through the alkaline protease enzymolysis, then through 5kD the ultrafilter membrane ultrafiltration obtain)
Embodiment five:
Prescription: Concha Haliotidis 200g Flos Buddlejae 200g Borneolum Syntheticum 2g
Collagen protein extracting solution 200ml (containing collagen protein 4g)
Collagen extraction liquid 100ml (containing collagen 20mg)
Method for making: get Flos Buddlejae, add 10 times of water gagings, extraction by steam distillation volatile oil is collected distillate 600ml, and is standby; Get Concha Haliotidis, be ground into fine powder, add 10 times of water gaging suspendibles even, regulate Ph6.0, add 1% papain, 60 ℃ of water-baths are hydrolyzed 6 hours, filter, add boric acid, Borax, add phenoxyethanol 2g, stir evenly, add vapor distillation liquid under stirring, then get Borneolum Syntheticum with dissolve with ethanol, add in above-mentioned mixed liquor under stirring, add the collagen protein extracting solution, then inject water to 3000ml, cross microporous filter membrane (0.22 μ m), aseptic subpackaged, and get final product.(annotate: collagen protein used be Colla Corii Asini through trypsin digestion, then through 5kD the ultrafilter membrane ultrafiltration obtain, collagen adopts citric acid solution to extract take Os Bovis seu Bubali as raw material, makes through papain enzymolysis, relative molecular weight is at 260～290kD.)
Embodiment six:
Prescription: Calamina 32.7g artificial Moschus 0.38g artificial Calculus Bovis 0.38g
Margarita 0.38g Borneolum Syntheticum 14.8g Borax 1.2g
Collagen protein 2g
Method for making: above seven flavors, Calamina, Margarita, Borax are ground into respectively impalpable powder; Artificial Moschus, artificial Calculus Bovis, Borneolum Syntheticum, collagen protein be porphyrize respectively; with above-mentioned powder facing-up; sieve; join in the liquid paraffin 20g that lets cool after sterilization, filtration; stir evenly; join again dry heat sterilization, filter and be chilled to approximately to stir evenly in the vaseline 890g of 50 ℃ and lanoline 40g and solidify, and get final product.(annotate: collagen protein used be new Colla Corii Asini through pepsin and trypsin bionic enzymatic, then through 3kD the ultrafilter membrane ultrafiltration obtain)
Embodiment seven:
Prescription: Pulvis Fellis Suis 2g Pulvis Cornus Bubali Concentratus 10g Margarita 20g
Borneolum Syntheticum 2g collagen protein 5g
Method for making: the above five tastes, mix, comminution by gas stream is crossed sieve No. nine, sterilization, and get final product.(annotate: collagen protein used be Corii Bovis seu Bubali and cattle heel string through papain enzymolysis, then through 3kD the ultrafilter membrane ultrafiltration obtain)
Embodiment eight:
Prescription: artificial Moschus 1g Margarita layer powder 20g collagen protein 3g
Method for making: get Margarita layer powder, be hydrolyzed to get Margarita layer powder hydrolysate 20ml, cross microporous filter membrane (0.22 μ m), standby; Get polyvinyl alcohol 30g, glycerol 5g, add in 50ml water for injection, be dipped to fully and run through, be heated to 80 ℃ of dissolvings to water-bath, namely get filmogen stock solution; Separately get artificial Moschus and collagen protein, inject water 20ml and make dissolving, then add Margarita layer powder hydrolysate, mixing adds in above-mentioned filmogen stock solution, stirs evenly, put 80 ℃ of water bath heat preservation 30min, then pour on glass plate (smearing with liquid paraffin in advance), manual masking is 2000cm approximately
2, 80 ℃ of forced air dryings, demoulding immediately takes out the 45min that sterilizes under uviol lamp, cut fritter, aseptic packaging and get final product.(annotate: collagen protein used be gelatin through bionic enzymatic, then through 3kD the ultrafilter membrane ultrafiltration obtain)
Embodiment nine:
Prescription: Margarita 20g glycyrrhizic acid dipotassium 1g collagen protein extracting solution 20ml (containing collagen protein 5g)
Method for making: get Margarita, powder is to fine powder, and heating water solves Margarita hydrolyzed solution 20ml; Collagen protein extracting solution and Margarita hydrolyzed solution are mixed, add glycyrrhizic acid dipotassium, add hydroxyethyl methylacrylate, ethylene glycol, grind well, add again 12% ammonium persulfate solution and 24% sodium metasulfite solution, fully grind well, get respectively the 5ml mixed liquor in evaporating dish, be placed in 37 ℃ of thermostatic water-circulator bath pot 3h.Take out, washing be placed on 4 ℃ standby.(annotate: collagen protein used be Corii Sus domestica and Corii Bovis seu Bubali through bionic enzymatic, then through 100kD the ultrafilter membrane ultrafiltration obtain)
Embodiment ten:
Get embodiment three gained gel for eye treatments xerophthalmia and examine patient's 47 examples, male 11 examples wherein, female's 36 examples, 28～58 years old age; The course of disease 1 month to 3 years; Be the eyes morbidity, totally 94 eyes, wherein computation work causer 16 examples, trachoma paralysis trace causer 6 examples, alkali burn causer 3 examples, causer 9 examples such as rheumatoid arthritis and lupus erythematosus disease, dermatosis, wear contact lenses causer 7 examples, sjogren syndrome causer 6 examples.4 times/d of administration, 1～2 droplet/time, 30 days is a course for the treatment of, observes after 2 courses for the treatment of.Cure 20 eyes (transference cure, corneal dyeing reduce, the Schirmer test repeatedly measure greater than 10mm＞/5min), 49 eyes that take a turn for the better (sx↓, corneal dyeing reduces, Schirmer tests and repeatedly measures lacrimal secretion and increase to some extent); Invalid 25 eyes (symptom is without improvement, and corneal dyeing is unchanged or increase, and the secretion that tear is repeatedly measured in the Schirmer test does not increase), effective percentage 79.5%.
Embodiment 11:
Get embodiment one gained eye drops in treatment asthenopia patient 143 examples, male 82 examples, female's 61 examples, 18～65 years old age, average 31.4 years old.Ophthalmic bloated 88 examples ((68.5%), blurred vision 78 examples (54.5%), xerophthalmia scheorma 71 examples (49.7%) wherein, upper eyelid sense of heaviness 64 examples (44.8%), dizzy 52 examples (39.8%), photophobia 28 examples (19.5%), ophthalmalgia 21 examples (14.7%); Fibroplasia 132 examples (92.3%) after corneal epithelium are shown in inspection, and conjunctiva mild hyperaemia 87 examples (60.8%) are the eyes morbidity.4 times/d of eye dripping, check after 2 months.As a result, the subjective sensation of ophthalmic uncomfortable all has alleviating in various degree, fibroplasia 121 examples that disappear after corneal epithelium, (84.6%), and discomfort alleviates 22 examples (15.4%), and conjunctiva mild hyperaemia sill disappears, total effective rate 100%; Vision, intraocular pressure sill do not change.
Claims (4)
1. a pharmaceutical composition that is used for the treatment of front screen syndrom, asthenopia, xerophthalmia, is characterized in that containing collagen protein in this pharmaceutical composition effective ingredient, and the compound mode of this pharmaceutical composition is as follows:
Radix Paeoniae Rubra 500g aloe gel 20:1 g Mentholum 0.5g contains the collagen protein extracting solution 200ml of collagen protein 2g.
2. pharmaceutical composition according to claim 1, is characterized in that collagen protein used is to be made through enzymolysis with key with key or cattle by gelatin, Colla Corii Asini, new Colla Corii Asini, Corii Sus domestica, Corii Bovis seu Bubali, Os Sus domestica, Os Bovis seu Bubali, pig, and its relative molecular weight is not higher than 10kD.
3. pharmaceutical composition according to claim 2, is characterized in that the relative molecular weight of collagen protein used is not higher than 5kD.
4. pharmaceutical composition described in claim 1 is for the preparation of the application in the medicine for the treatment of front screen syndrom, asthenopia, xerophthalmia.
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