CN101612306B - Traditional Chinese medicine composition for enhancing immunity and relieving fatigue and preparation method thereof - Google Patents
Traditional Chinese medicine composition for enhancing immunity and relieving fatigue and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for enhancing the immunity of a human body and relieving the fatigue of the human body and a preparation method thereof. In the invention, red ginseng/radix codonopsis pilosulae, manyprickle acanthopanax root, ophiopogon root and Chinese magnoliavine are used as preparation raw materials, and the effective components of the preparation raw materials are extracted to prepare various traditional Chinese medicine preparation.The traditional Chinese medicine composition of the invention not only has the advantages of immunity regulating and fatigue relieving, but also has the advantages of circulation improving, cardiac muscle protecting, oxygen deficiency resistant capability enhancing, lung astringing and kidney nourishing.
Description
Technical field
The present invention relates to a kind of raising body immunity, the Chinese medicine composition of relieving fatigue, and this Chinese medicine composition is prepared into the method for oral formulations or beverage.
Background technology
The Chinese traditional treatment immunological disease has definite curative effect, no matter aspect pain relieving, still aspect immunomodulating, or reduces hormone dependence aspect, and significant curative effect is arranged.
The traditional Chinese medical science think immunological diseases generation and development is main has closely related with factors such as natural endowment deficiency, heresy of diseases caused by exogenous pathogenic factor six climate exopathogens, the four stages in the course of an epidemic febrile disease imbalance, the dirty dysfunction of internal organs, the interior lifes of phlegm-turbidity and blood stasis blood.The transient cause that the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens is disease, natural endowment deficiency, the four stages in the course of an epidemic febrile disease imbalance, the dirty dysfunction of internal organs etc. are immanent causes.The traditional Chinese medical science thinks that kidney, spleen and erythropoiesis and hematid immunity function are in close relations, and the hemopoietic function of bone marrow is mainly from kidney, spleen, " kidney storing essence, give birth to marrow, main bone ", spleen " middle Jiao extracting juice of being bullied, change and red be meaning blood ".The transporting and transforming function of the spleen and stomach essence of water and grain must be under the kidney yang impetus, the angry blood of abilityization.The traditional Chinese medical science uses drugs for nourishing qi and activating blood to improve the activity of erythrocyte complement receptors, thereby improves red blood cell adhesion immune complex function, the effect of performance erythrocyte immune.Treatment anaphylaxis aglobuliosis there is good curative effect.Thereby traditional Chinese medical science immunology thinks that there are the performance regulating action in kidney, spleen, lung dialogue cell immune system and erythrocyte immune system.
Everybody knows that also a variety of diseases all because body immunity decline causes, improve immunity and help prevention and reduce multiple disease.There is minority to have the immunologic function that strengthens human body in the market, relieving fatigue Chinese medicine composition or functional beverage are seldom arranged, lack the immunologic function and relieving fatigue Chinese medicine composition or the functional beverage that have the enhancing human body simultaneously.And there are some Chinese medicine compositions that immunologic function or the relieving fatigue of certain enhancing human body are arranged on the market, but not the main effect as product, just be mainly used in antitumor, antiviral, defying age, infection, blood sugar lowering, have concurrently on the basis of various diseases such as treatment hepatitis B and improve immunologic function or relieving fatigue effect, from another angle, act on more many, just more big for its side effect of the user who does not need the associated treatment purpose, therefore take these multiduty Chinese patent medicines for a long time, side effect is bigger.
Summary of the invention
Purpose of the present invention just provides a kind of immunologic function that strengthens human body, the Chinese medicine composition of relieving fatigue.
Another object of the present invention is to provide above-mentioned Chinese medicine composition to make the method for oral formulations, Chinese medicinal drink.
The object of the present invention is achieved like this: a kind of Chinese medicine composition that improves immunity and relieving fatigue is characterized in that the preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Ginseng Rubra 6～12 Radix Et Caulis Acanthopanacis Senticosis 10～20
Radix Ophiopogonis 8～16 Fructus Schisandrae Chinensis 4～8
The above-mentioned best proportioning that respectively prepares raw material is as follows in weight portion:
Radix Ginseng Rubra 8～10 Radix Et Caulis Acanthopanacis Senticosis 17～19
Radix Ophiopogonis 11～13 Fructus Schisandrae Chinensis 5～7
In the aforementioned pharmaceutical compositions, Radix Ginseng Rubra can substitute with the Radix Codonopsis of its 3 times of amount.
Another object of the present invention is achieved in that the preparation method of above-mentioned Chinese medicine composition, it is characterized in that: each preparation raw material is prepared burden in described ratio, extract the extracting solution that respectively prepares raw material routinely, preparation obtains Chinese medicinal drink or adopts the conventional formulation technology to make the extract oral solid preparation again.
Wherein, Radix Ginseng Rubra or Radix Codonopsis, Radix Et Caulis Acanthopanacis Senticosi are taked the alcohol extracting method effective component extracting, add water precipitating filter Radix Ginseng Rubra or Radix Codonopsis, acanthopanax senticosus extract; Take Fructus Schisandrae Chinensis, Radix Ophiopogonis water extraction to obtain Fructus Schisandrae Chinensis and Radix Ophiopogonis extract, each extracting solution are mixed, be dissolved in water again, standardize solution, sterilize Chinese medicinal drink.
Above-mentioned Chinese medicine composition is made Chinese medicinal drink, also can adopt following steps to make: the preparation raw material in described ratio is prepared burden; The method of extracting by suitable each material effective component prepares various raw water liquid; Mix each raw water liquid, filter, add water in the filtrate, adjust pH value to 5～8 and get Chinese medicinal drink.
Specifically, it carries out as follows:
A. the preparation of Radix Ginseng Rubra or Radix Codonopsis water liquid
Red ginseng powder is broken into particulate, uses alcohol reflux 4～5 times, each 2 hours, the merging of each time extracting solution is obtained extracting solution; The cold preservation of gained extracting solution, filtration, concentrated get the thick paste thing until extracting solution being concentrated into the thick paste shape; Gained thick paste thing adds that water stirs evenly, cold preservation, filtration obtain Radix Ginseng Rubra or Radix Codonopsis water liquid;
B. the preparation of Fructus Schisandrae Chinensis water liquid
Fructus Schisandrae Chinensis is decocted with water 2 times, each 1 hour, the merging of each time decocting liquid is obtained mixing decocting liquid; Gained mixing decocting liquid filters, is concentrated into the thick paste thing of thick paste shape; Gained thick paste thing adds ethanol and carries out precipitate with ethanol, makes the alcohol amount that contains of thick paste thing reach 60～70%, filters merging filtrate then; Gained filtrate is adopted ethanol to reclaim also and is concentrated into the thick paste shape, adds that water stirs evenly, cold preservation, filtration obtains Fructus Schisandrae Chinensis water liquid again;
C. the preparation of Radix Et Caulis Acanthopanacis Senticosi water liquid, Radix Ophiopogonis water liquid preparation
Prepare Radix Et Caulis Acanthopanacis Senticosi water liquid according to the method for preparing Radix Ginseng Rubra water liquid; Prepare water liquid Radix Ophiopogonis according to the method for preparing Fructus Schisandrae Chinensis water liquid;
(2) Radix Ginseng Rubra that will make by material rate or Radix Codonopsis water liquid, Fructus Schisandrae Chinensis water liquid, Radix Et Caulis Acanthopanacis Senticosi water liquid and Radix Ophiopogonis water liquid mix homogeneously, obtain mixing water liquid; Gained mixing water liquid filters, and adds water and adjusts pH value to 5～8; Refilter, embedding, sterilize Chinese medicinal drink.
The present invention also provides a kind of above-mentioned Chinese medicine composition has been made the method for various oral formulations, and it comprises the steps: that (1) described preparation raw material prepares burden in proportion, decoct with water respectively decocting liquid; Merge each decocting liquid and must mix decocting liquid; (2) concentrated mixing decocting liquid and cooling back adding ethanol leave standstill, filter, collection filtrate; Gained filtrate is carried out concentrating under reduced pressure and is got the thick paste thing; (3) in thick paste, add conventional adjuvant, carry out the conventional post processing of extract oral solid preparation again.
Specifically, it carries out as follows:
(1) takes by weighing the preparation raw material in described ratio; Each raw material is decocted with water respectively 2 times, decocted 1.5 hours at every turn, get each decocting liquid; Merge each decocting liquid and filter to such an extent that mix decocting liquid;
(2) concentrate to mix decocting liquid to the decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is 70%, leaves standstill 2 hours, filtration; The gained filtrate decompression is condensed into the thick paste thing;
(3) add conventional adjuvant in thick paste thing filtrate, preparation technique makes the extract oral solid preparation routinely.
The present invention carries out prescription according to theory of Chinese medical science, and the traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, thereby emphasizes that kidney has adjustment and keeps immunologic balance and stable important function thereof.Kidney not only shows whole adjusting to the regulating action of immunity, and is simultaneously relevant with intracellular adjusting.Losing of kidney is empty, endocrine regulation can occur.The traditional Chinese medical science thinks that also spleen is the foundation of acquired constitution.Spleen is the glandular organ of human body maximum, also is the place of mainly living away from home of immunocyte.Losing of spleen is empty, and its cellular immunization and humoral immune function are all low than the normal person.This product starts with to reach the effect that improves immunity, resisting fatigue with the kidney invigorating, strengthening the spleen, the QI invigorating multi-angle that nourishes heart: Radix Ginseng Rubra or Codonopsis's Radix Ginseng class, and the little hardship of sweet temperature, strongly invigorating primordial QI helps intensive culture god, is monarch drug; Join the hot temperature of Radix Et Caulis Acanthopanacis Senticosi, be the gas medicine of blood system, the effect of the Radix Ginseng of enhancing is arranged, increase Abwehrkraft des Koepers, can increase the usefulness of muscle power, be ministerial drug; Radix Ophiopogonis is sweet cold, and YIN nourishing and the production of body fluid promoting is adjuvant drug: the trimethyl gallic acid temperature, astringing QI promotes the production of body fluid, and is messenger drug: all medicines are played strongly invigorating primordial QI, the merit of YIN nourishing and the production of body fluid promoting altogether with 5.Fatigue and weakness appears in the people of all qi-blood-body fluid deficiencies that has a delicate constitution, the cardiopalmus of breathing hard, and diseases such as spontaneous perspiration can be used, and really are physical strength reinforcing, resistance and immunologic function, the good recipe of suiting the medicine to the illness of resisting fatigue, the good merchantable brand that tonify deficiency is set upright.
Effect of the present invention is interacted, coordinates mutually and embodied jointly by material.Have strongly invigorating primordial QI, the merit of YIN nourishing and the production of body fluid promoting can be used for improving effects such as body immunity, fatigue alleviating.
Pharmacology analysis shows: Radix Ginseng Rubra is the processed product of Radix Ginseng, and its active ingredient is the ginsenoside, has the circulation of improvement, promotes effects such as substance metabolism and protein synthesis; Radix Codonopsis effect and Radix Ginseng Rubra are approximate; Radix Et Caulis Acanthopanacis Senticosi belongs to Qi-tonifying drug, and its active ingredient is eleutheroside, has tonify deficiency and helps the weak, improves hypoxia-bearing capability, stimulates the mind ﹠ body vigor, can prevent or treat the disease that has a delicate constitution, strengthening by means of tonics; Radix Ophiopogonis, effective ingredient was ophiopogonin, had effects such as the myocardial contraction of improvement and heart pump function, protection cardiac muscle; Fructus Schisandrae Chinensis has the nourishing kidney of astringing the lung, the arresting sweating that promotes the production of body fluid, the effects such as biosynthesis of arresting seminal emission antidiarrheal, promotion hepatic protein and glycogen.Four share from protecting cardiac muscle, enhance metabolism, improve hypoxia-bearing capability multi-angle synergism, and common performance improves the immunologic function that strengthens human body, alleviate or the effect of allaying tiredness symptom.And raw material that the present invention adopts is the medical material of health food, can take for a long time, has no adverse reaction.
The specific embodiment
Below in conjunction with embodiment and experimental example the present invention is elaborated:
Embodiment 1: a kind of Chinese medicine composition that improves immunity and relieving fatigue, and the preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Ginseng Rubra 9 Radix Et Caulis Acanthopanacis Senticosis 18
Radix Ophiopogonis 12 Fructus Schisandrae Chinensis 6
Above-mentioned raw materials is extracted according to a conventional method the effective ingredient of each raw material respectively; Mix each material effective component and be dissolved in water, add the water standardize solution then, sterilize Chinese medicinal drink.
Embodiment 2: a kind of method of compositions of the present invention being made Chinese medicinal drink is provided.The preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Codonopsis 9 Radix Et Caulis Acanthopanacis Senticosis 6
Radix Ophiopogonis 4 Fructus Schisandrae Chinensis 2
Radix Codonopsis, Radix Et Caulis Acanthopanacis Senticosi are taked the alcohol extracting method effective component extracting, add water and get Radix Codonopsis water liquid, Radix Et Caulis Acanthopanacis Senticosi water liquid; Take Fructus Schisandrae Chinensis, Radix Ophiopogonis water extraction to extract its effective ingredient, add water and get Fructus Schisandrae Chinensis water liquid, Radix Ophiopogonis water liquid; Mix each raw water liquid, filter, add water in the filtrate, adjust pH value to 5～8 and get Chinese medicinal drink.
Embodiment 3: a kind of method of compositions of the present invention being made Chinese medicinal drink is provided.The preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Codonopsis 18 Radix Et Caulis Acanthopanacis Senticosis 10
Radix Ophiopogonis 8 Fructus Schisandrae Chinensis 5
Preparation method is as follows:
(1) preparation raw water liquid, wherein
A. the preparation of Radix Codonopsis water liquid
Radix Codonopsis powder is broken into particulate, uses alcohol reflux 4～5 times, each 2 hours, the merging of each time extracting solution is obtained extracting solution; The cold preservation of gained extracting solution, filtration, concentrated get the thick paste thing until extracting solution being concentrated into the thick paste shape; Gained thick paste thing adds that water stirs evenly, cold preservation, filtration obtain Radix Codonopsis water liquid:
B. the preparation of Fructus Schisandrae Chinensis water liquid
Fructus Schisandrae Chinensis is decocted with water 2 times, each 1 hour, the merging of each time decocting liquid is obtained mixing decocting liquid; Gained mixing decocting liquid filters, is concentrated into the thick paste thing of thick paste shape; Gained thick paste thing adds 95% ethanol and carries out precipitate with ethanol, makes the alcohol amount that contains of thick paste thing reach 80% for the first time, makes the alcohol amount that contains of thick paste thing reach 85% for the second time, filters merging filtrate then; Gained filtrate is adopted ethanol to reclaim also and is concentrated into the thick paste shape, adds that water stirs evenly, cold preservation, filtration obtains Fructus Schisandrae Chinensis water liquid again;
C. the preparation of Radix Et Caulis Acanthopanacis Senticosi water liquid, Radix Ophiopogonis water liquid preparation
Prepare Radix Et Caulis Acanthopanacis Senticosi water liquid according to the method for preparing Radix Codonopsis water liquid; Prepare water liquid Radix Ophiopogonis according to the method for preparing Fructus Schisandrae Chinensis water liquid;
With the above-mentioned Radix Codonopsis water liquid that makes by material rate, Fructus Schisandrae Chinensis water liquid, Radix Et Caulis Acanthopanacis Senticosi water liquid and Radix Ophiopogonis water liquid mix homogeneously, obtain mixing water liquid; Gained mixing water liquid filters, and adds water and adjusts pH value to 5～8; Refilter, embedding, sterilize Chinese medicinal drink.
Embodiment 4: a kind of method of compositions of the present invention being made oral solid formulation is provided.The preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Ginseng Rubra 6 Radix Et Caulis Acanthopanacis Senticosis 10
Radix Ophiopogonis 8 Fructus Schisandrae Chinensis 4
Its preparation technology comprises the steps:
(1) takes by weighing the preparation raw material in described ratio; Each raw material is decocted with water respectively 2 times, decocted 1.5 hours at every turn, get decocting liquid; Merge each decocting liquid and filter to such an extent that mix decocting liquid;
(2) concentrate to mix decocting liquid to 1/3 of decocting liquid original volume, after be cooled to room temperature; Add 95% again, regulating concentration of alcohol is 70%, leaves standstill 2 hours, filtration; The gained filtrate decompression is condensed into the thick paste thing;
(3) in thick paste thing filtrate, add dextrin, make the extract oral solid preparation by existing preparation technique.
In order to show that the beverage or the oral formulations that make by the method for the invention have appreciable impact to immune function of mice, the spy carries out following experiment:
Experiment 1: per os give the mice various dose by the write out a prescription sample 30 days of preparation of the present invention, carry out the mouse lymphocyte conversion capability detection that ConA induces, result and statistical data can be found by experiment, in low high dose group compare lymphocytic multiplication capacity with matched group and strengthen, difference has highly significant (P＜0.01).Be that each dosage group of goods of the present invention all can significantly improve the mouse lymphocyte conversion capability that ConA induces.The T cell externally can transform after being subjected to the effect of non-specific mitogen such as ConA, breed and be lymphoblast, and its conversion ratio can reflect cell immune function of human body.
The influence of the mouse spleen lymphocyte transformation experiment that table 1 goods of the present invention are induced ConA
Experiment 2: per os gives the goods of the present invention 30 days of mice various dose, carries out the serum hemolysin horizontal detection, and result and statistical data can be found by experiment, high dose group and matched group comparison, and difference has highly significant (P＜0.01).Be that high dose group of the present invention can improve mice half hemolysis value (HC
50), have the effect that strengthens the mouse humoral immune function.And the mensuration of half hemolysis value has reflected the proliferation and differentiation of B cell and be combined the ability of back secretion hemolysin in the body fluid with complement, and hemolysin is the anti-sheep red blood cell antibody of specificity, can be used for estimating being tried thing to the humoral immune function of body.
Table 2 goods of the present invention are to mice half hemolysis value (HC
50) effect
Experiment 3: per os gives the goods of the present invention 30 days of mice various dose, carry out the detection of mouse macrophage chicken red blood cell phagocytic rate and phagocytic index, result and statistical data can be found by experiment, being tried thing influences bigger to phagocytic rate, low, in, high dose group and matched group are relatively, mouse macrophage engulfs the chicken red blood cell phagocytic percentage and phagocytic index all is higher than the solvent control group, wherein high dose group has extremely significantly meaning (P＜0.01), point out under this experimental condition goods of the present invention that mouse macrophage is engulfed the chicken red blood cell ability tangible rising is arranged, in, high dose group has the effect that strengthens macrophage phagocytosis of mice, macrophage can nonspecificly be engulfed multiple antigen, so measure the power that macrophage phagocytic function can reflect the body non-specific immunity.
Table 3 goods of the present invention are engulfed the influence of chicken red blood cell test to Turnover of Mouse Peritoneal Macrophages
Experiment 4: per os gives the goods of the present invention 30 days of mice various dose, carries out the NK cytoactive and detects, and result and statistical data can be found by experiment, and low dose group and matched group relatively do not have significant difference, and then there were significant differences for middle and high dosage group.Difference all has significance difference (P＜0.01).Show that this product can improve the NK cells in mice activity in middle and high dosage group.The NK cell has important function in viral infection resisting, the mensuration of NK cytoactive has also been reflected the kill capability of body to the target cell of kinds of tumors and viral infection.
Table 4 goods of the present invention are to the influence of NK cells in mice activity
Annotate: the above-mentioned experiment that the present invention carries out is all undertaken by this area conventional method.
Claims (9)
1. Chinese medicine composition that improves immunity and relieving fatigue is characterized in that the preparation raw material of its contained active ingredient is as follows in weight portion:
Radix Ginseng Rubra 8～10 Radix Et Caulis Acanthopanacis Senticosis 17～19
Radix Ophiopogonis 11～13 Fructus Schisandrae Chinensis 5～7.
2. Chinese medicine composition as claimed in claim 1, Radix Ginseng Rubra wherein replaces with the Radix Codonopsis of 3 times of Radix Ginseng Rubra amounts.
3. the preparation method of Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that: each preparation raw material is prepared burden in described ratio, extract the extracting solution that respectively prepares raw material routinely, preparation obtains Chinese medicinal drink or adopts the conventional formulation technology to make the extract oral solid preparation again.
4. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that: each preparation raw material is prepared burden in proportion; Wherein Radix Ginseng Rubra or Radix Codonopsis, Radix Et Caulis Acanthopanacis Senticosi are taked the alcohol extracting method effective component extracting, add water precipitating filter Radix Ginseng Rubra or Radix Codonopsis, acanthopanax senticosus extract; Take Fructus Schisandrae Chinensis, Radix Ophiopogonis water extraction to obtain Fructus Schisandrae Chinensis and Radix Ophiopogonis extract, each extracting solution is mixed, preparation obtains Chinese medicinal drink.
5. the preparation method of Chinese medicine composition as claimed in claim 4 is characterized in that: after each extracting solution is mixed, be dissolved in water, standardize solution, sterilize Chinese medicinal drink.
6. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that comprising the steps: that the preparation raw material in described ratio prepares burden; The method of extracting by suitable each material effective component prepares various raw water liquid; Mix each raw water liquid, filter, add water in the filtrate, adjust pH value to 5～8 and get Chinese medicinal drink.
7. the preparation method of Chinese medicine composition as claimed in claim 6 is characterized in that:
(1) preparation of each raw water liquid
A. the preparation of Radix Ginseng Rubra or Radix Codonopsis water liquid
Radix Ginseng Rubra or Radix Codonopsis powder are broken into particulate, use alcohol reflux 4～5 times, each 2 hours, the merging of each time extracting solution is obtained extracting solution; The cold preservation of gained extracting solution, filtration, concentrated get the thick paste thing until extracting solution being concentrated into the thick paste shape; Gained thick paste thing adds that water stirs evenly, cold preservation, filtration obtain Radix Ginseng Rubra or Radix Codonopsis water liquid;
B. the preparation of Fructus Schisandrae Chinensis water liquid
Fructus Schisandrae Chinensis is decocted with water 2 times, each 1 hour, the merging of each time decocting liquid is obtained mixing decocting liquid; Gained mixing decocting liquid filters, is concentrated into the thick paste thing of thick paste shape; Gained thick paste thing adds ethanol and carries out precipitate with ethanol, makes the alcohol amount that contains of thick paste thing reach 60～70%, filters merging filtrate then; Gained filtrate is adopted ethanol to reclaim also and is concentrated into the thick paste shape, adds that water stirs evenly, cold preservation, filtration obtains Fructus Schisandrae Chinensis water liquid again;
C. the preparation of Radix Et Caulis Acanthopanacis Senticosi water liquid, Radix Ophiopogonis water liquid preparation
Prepare Radix Et Caulis Acanthopanacis Senticosi water liquid according to the method for preparing Radix Ginseng Rubra water liquid; Prepare water liquid Radix Ophiopogonis according to the method for preparing Fructus Schisandrae Chinensis water liquid;
(2) Radix Ginseng Rubra that will make by material rate or Radix Codonopsis water liquid, Fructus Schisandrae Chinensis water liquid, Radix Et Caulis Acanthopanacis Senticosi water liquid and Radix Ophiopogonis water liquid mix homogeneously, obtain mixing water liquid; Gained mixing water liquid filters, and adds water and adjusts pH value to 5～8; Refilter, embedding, sterilize Chinese medicinal drink.
8. the preparation method of Chinese medicine composition as claimed in claim 1 or 2 is characterized in that comprising the steps:
(1) described preparation raw material is prepared burden in proportion, decoct with water respectively decocting liquid; Merge each decocting liquid and must mix decocting liquid;
(2) concentrated mixing decocting liquid and cooling back adding ethanol leave standstill, filter, collection filtrate; Gained filtrate is carried out concentrating under reduced pressure and is got the thick paste thing;
(3) in thick paste, add conventional adjuvant, carry out the conventional post processing of extract oral solid preparation again.
9. the preparation method of Chinese medicine composition as claimed in claim 8 is characterized in that comprising the steps:
(1) takes by weighing the preparation raw material in described ratio; Each raw material is decocted with water respectively 2 times, decocted 1.5 hours at every turn, get each decocting liquid; Merge each decocting liquid and filter to such an extent that mix decocting liquid;
(2) concentrate to mix decocting liquid to the decocting liquid original volume 1/3 after be cooled to room temperature; Adding 95% ethanol again and regulating determining alcohol is 70%, leaves standstill 2 hours, filtration; The gained filtrate decompression is condensed into the thick paste thing;
(3) add conventional adjuvant in thick paste thing filtrate, preparation technique makes the extract oral solid preparation routinely.
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| CN102763881A (en) * | 2012-08-09 | 2012-11-07 | 重庆加多宝饮料有限公司 | Acanthopanax, radix ophiopogonis and red ginseng drink and preparation method thereof |
| CN102860511A (en) * | 2012-10-09 | 2013-01-09 | 三普药业股份有限公司 | Antioxidant anti-anoxia health food and preparation method thereof |
| CN110122718A (en) * | 2019-06-10 | 2019-08-16 | 重庆柠柠柒饮料有限公司 | The beverage of the gentle physical fatigue of strengthen immunity |
| CN114224956B (en) * | 2022-02-08 | 2023-03-10 | 黑龙江中医药大学 | Anti-fatigue composition containing acanthopanax senticosus and preparation and application thereof |
| CN115779033A (en) * | 2022-12-08 | 2023-03-14 | 江苏七○七天然制药有限公司 | Qi-tonifying and nerve-soothing tablet and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078152A (en) * | 1993-01-01 | 1993-11-10 | 华西医科大学制药厂 | SHENGMAI ZHUSHEYE and preparation technology thereof |
| CN101322570A (en) * | 2007-06-11 | 2008-12-17 | 哈尔滨完达山药业有限公司 | Process for preparing acanthopanax root drink |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078152A (en) * | 1993-01-01 | 1993-11-10 | 华西医科大学制药厂 | SHENGMAI ZHUSHEYE and preparation technology thereof |
| CN101322570A (en) * | 2007-06-11 | 2008-12-17 | 哈尔滨完达山药业有限公司 | Process for preparing acanthopanax root drink |
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