CN101590217B - Chinese medicinal composition for treating dysthymia and preparation method thereof - Google Patents

Abstract

The invention discloses a Chinese medicinal composition for treating dysthymia and a preparation method thereof. Based on the treatment principle of the Chinese medicine on the dysthymia, referring to the modern pharmacological research, following the theory of the Chinese medicine and insisting on the principle of oral Chinese medicinal preparation orientation, the treatment is carried out. Radix salviae miltiorrhizae, angelica, glossy ganoderma, schisandra, fructus viticis and herba cistanches are used as monarch medicaments for strengthening the spleen and replenishing qi, nourishing the blood and relieving the mind, activating blood circulation to dissipate blood stasis, strengthening body resistance and eliminating evil, adjusting the stability of the internal and external environments of the body, and coordinating and balancing the external environment of the body; cortex albiziae, vine of tuber fleeceflower, balsam pear, mulberry, ginger and the like are used as ministerial medicaments for soothing liver-qi stagnation and supplementing the heart and spleen; valerian root, chrysanthemum, osmanthus flower, fennel and gardenia are used as adjuvant for calming nerves and tranquilizing, dispelling wind and spasmolysis; and szechuan lovage rhizome, medlar, longan pulp, dwarf lilyturf root and honey are used as adjuvant medicaments for tonifying the heart and spleen, supplementing qi and blood, nourishing Yin and easing dysphoria, coordinating heart and kidney, and have good functions of nourishing and supplementing.

Description

A kind of Chinese medicine composition for the treatment of dysthymia and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition for the treatment of dysthymia and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Along with Chinese society's rapid economy development, the quickening of urbanization and aged tendency of population process, and the influence of factors such as competitiveness, unemployment, rhythm of life variation, mental sickness is more and more outstanding and serious to the harm of Chinese people's health.Cause psychosis, the insomnia, depression, anxiety neurosis, various mental sickness such as schizophrenia sharply rise, because the mental sickness sickness rate increases day by day, are called as " the stealthy killer of 21 century ".Current treatment mental sickness types of drugs is various, and simple western medicine has dependency, and the treatment side effect is big, the time is long, and occurs the disconnected symptom in rank easily even serial reaction occurs, have in addition need take medicine major injury hepatic and renal function, formation vicious cycle all the life.

Summary of the invention

The inventor thinks that in research practice all by due to the heart, the liver,spleen,kidney four dirty functional disorders, The heart controls mental activities for primary disease, for brain, feelings will activity president in heart and brain, the activity of feelings will is adjusted in liver, and liver is dredged and to rush down bar and reach QI movement being in harmonious way, the fluent harmony of feelings will, internal organs YIN and YANG in a relative equilibrium, then all diseases are not given birth to.

A kind of Chinese medicine composition for the treatment of dysthymia of the present invention and preparation method thereof, based on the Therapeutic Principle of China's traditional medicine to dysthymia, with reference to modern pharmacological research, follow tcm theory, grasping with the oral Chinese medicine preparation is that the principle of basis is treated.With Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Ganoderma, Fructus Schisandrae Chinensis, Fructus Viticis, Herba Cistanches be the monarch drug invigorating the spleen and benefiting QI, the appropriate god that nourishes blood, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors are adjusted the stable of body internal and external environment, and body external environment coordinated balance; With Cortex Albiziae, Caulis Polygoni Multiflori, Fructus Momordicae charantiae, Fructus Mori, Semen Ziziphi Spinosae, Succus Bambusae, Rhizoma Zingiberis Recens is ministerial drug, controls and gives dispersing the stagnated live-QI to relieve the stagnation of QI, and invigorating the heart and spleen, is eliminated phlegm for resuscitation at heat-clearing and toxic substances removing; With Rhizoma et radix valerianae, Flos Chrysanthemi, Flos Osmanthi Fragrantis, Fructus Foeniculi, Fructus Gardeniae is the accessory drugs calmness of calming the nerves, the wind dispelling spasmolytic; With Rhizoma Chuanxiong, Fructus Lycii, Arillus Longan, Radix Ophiopogonis, Mel is the adjuvant drug heart-spleen boosting, fills blood, and the YIN nourishing profit is hot-tempered, and restoring normal coordination between the heart and kidney has good nourishing benefiting action.

The property of medicine and the pharmacology of the selected Chinese herbal medicine of the present invention are respectively:

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] hardship is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, relieving restlessness clears away heart-fire.Be used for menoxenia, the amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, what " herbal classic " called is slightly cold, and TAO Hong-Jing has been doubted its mistake, and Miao's secondary alcohol is also doubted it, and stupid to a stone is to transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaking water, and cold and heat gather; Broken disease is removed abdominal mass, ends stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Remove wind Xing and stay heat, obey sharp people for a long time.TAO Hong-Jing: the stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, painful numbness, main attacked by pestiferous factors; Control stomachache, gas is done the sound ring and is shouted." Japan hanako materia medica ": the sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; The evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood is mended new hemopoietic; Peaceful tire, stillborn fetus falls; Under the hemostasis metrorrhagia and leukorrhagia, transfer married woman's passages through which vital energy circulates irregular, the blood evil thought is tired; Malignant boil scabies, the wart toxic swelling of going to live in the household of one's in-laws on getting married, erysipelas; Headache, acute conjunctivitis, the heat temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia is spitted blood mastitis, carbuncle.

Radix Angelicae Sinensis:

[meridian distribution of property and flavor] is warm in nature, hides sweet, hot.GUIXIN, Liver Channel.

[function cures mainly] enriched blood and invigorated blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.

Ganoderma:

[meridian distribution of property and flavor] is sweet, and be flat.GUIXIN, lung, liver, kidney channel.

[function cures mainly] cures mainly asthenia, cough, asthma, insomnia, dyspepsia, malignant tumor etc.Animal pharmacology shows experiment: Ganoderma has inhibitory action to nervous system, and blood circulation has blood pressure lowering and strengthens the effect of cardiac contractile force, and respiratory system is had phlegm-dispelling functions, in addition, also has hepatoprotective, improves immunologic function, antibioticly waits effect.

Fructus Schisandrae Chinensis:

[meridian distribution of property and flavor] sour in the mouth, sweet, temperature.Return lung, the heart, kidney channel.

[function cures mainly] convergence is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, kidney calming.Be used for the chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, the deficient pulse of losing heart, interior-heat is quenched one's thirst, palpitation and insomnia.

Fructus Viticis:

[meridian distribution of property and flavor] is hot, bitter, is slightly cold.Return bladder, liver, stomach warp.

[function cures mainly] dispelling wind and heat pathogens, the clear sharp head.Be used for the anemopyretic cold headache, gingivitis, the many tears of conjunctival congestion, poor vision is had a dizzy spell.

Herba Cistanches:

[meridian distribution of property and flavor] is warm in nature, sweet in the mouth, salty;

[effect] supports the five internal organs, reinforcing YIN-essence, and beneficial vital essence is used for insufficiency of kidney-YANG, essence and blood void thanks to, sexual impotence or infertile, soreness of the waist and knees, muscles and bones is unable; The dryness of the intestine constipation.

Cortex Albiziae:

[nature and flavor] are sweet, and are flat.

[function] be resolving stagnation for tranquilization 1.: control that melancholy is not relaxed, insomnia forgetfulness.2. promoting blood circulation and detumescence: control carbuncle sore, lung abscess, traumatic injury,, pain due to blood stasis.

Caulis Polygoni Multiflori:

[meridian distribution of property and flavor]: sweet little hardship, flat.1. " book on Chinese herbal medicine is new again ": " bitter in the mouth, warm in nature, nontoxic." 2. " decoction pieces is newly joined ": " pained little sweet." 3. " Shaanxi Chinese herbal medicine ": " property is flat, sweet in the mouth." go into the heart, spleen, kidney, Liver Channel.1. " book on Chinese herbal medicine is new again ": " go into the heart, spleen two warps." 2. " Sichuan Chinese medicinal herbal ": " go into liver, kidney two warps.”

[effect]: nourish heart, calm the nerves, collateral dredging dispels the wind,

[curing mainly]: control the insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies.

Fructus Momordicae charantiae:

[meridian distribution of property and flavor] hardship, cold.Return spleen, stomach, the heart, Liver Channel.

[effect] heat clearing away heart-fire of dispelling, detoxifcation makes eye bright, and the QI invigorating benefit is smart, quenches the thirst and relieves summer heat, and controls carbuncle.

Fructus Mori:

[meridian distribution of property and flavor] is sweet, is slightly cold.GUIXIN, liver, kidney channel.

[curing mainly]: the treating the liver kidney yin is lost, and send and take off, constipation, order is dark, tinnitus, former infections, articular instability.It has the skin of improvement (comprising scalp) blood supply, the nutrition skin, makes effect such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is be healthy and strong U.S. face, antidotal good fruit and a good medicine of middle-aged and elderly people.Normal food Fructus Mori can make eye bright, the tired dry and astringent symptom of easing eyes.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, and reaction has potentiation to hemolytic, can prevent human body artery sclerosis, skeleton arthrosclerosis, enhances metabolism; Fructus Mori can promote the growth of erythrocyte, prevents leukopenia, and diseases such as treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurasthenia are had auxiliary curative effect.Fructus Mori has effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science thinks that Fructus Mori is sweet in flavor and cold in property, has the liver and the kidney tonifying, an effect such as the intestine moistening of promoting the production of body fluid, black hair make eye bright.

Semen Ziziphi Spinosae:

[nature and flavor] are sweet, and are flat.1. " herbal classic ": sour in the mouth is flat.2. " not Lu ": nontoxic.3. amplification on Canon of Materia Medica: tepor.4. principle of Correct Diet: sour in the mouth is sweet, and is flat.

[return through] goes into the heart, spleen, liver, gallbladder meridian.1. " detailed outline ": the sufficient the moon of fainting, few sun.2. " Thunder God is concocted the property of medicine and is separated ": go into the heart, spleen, liver, gallbladder four warps.

[function cures mainly] nourishing the liver, mind calming is calmed the nerves, arresting sweating.Control restlessness of asrhenia type and insomnia, palpitation with fear palpitation with a distress feeling, excessive thirst, sweating due to debility.

Succus Bambusae:

[return through] heart; Liver; Lung meridian

[function cures mainly] controls middle wind-phlegm fan, and lung-heat expectorant is stopped up, infantile convulsion, epilepsy, high fever excessive thirst, restlessness during pregnancy, tetanus.Removing heat-phlegm: cure mainly phlegm-heat cough, the yellow thickness of expectorant; Also can be used for expectorant heat and hoodwink key clearly; Expectorant is pined for wind, the stiff tongue hemiplegia; Infantile convulsion, tic of the limbs is often joined removing heat-phlegm, the dispelling wind and relieving convulsion medicine.Effect: resolving heat and reducing pathogenic fire; The sharp key of sliding expectorant.

Rhizoma Zingiberis Recens:

[meridian distribution of property and flavor] acrid in the mouth, tepor, nontoxic; Go into lung, the heart, stomach, spleen four warps;

[effect] delivered, cold expelling, and preventing or arresting vomiting is opened expectorant, carbuncle skin ulcer.

Rhizoma et radix valerianae:

[meridian distribution of property and flavor] be " Sichuan Chinese medicinal herbal " 1.: " the acrid in the mouth hardship, warm in nature, little poison is arranged." 2. " Xinjiang Chinese herbal medicine handbook: " acrid in the mouth is little sweet, warm in nature, nontoxic." 3. " Sichuan Chinese medicinal herbal ": " goes into the heart, liver two warps.″

[function cures mainly] is in harmony irritability, a little less than the stomach, and lumbago, menoxenia, traumatic injury.1. " medicinal herbs among the people of science ": " be used for the neurasthenia, spirit is uneasy." 2. " Shandong Chinese medicine ": " controls women's amenorrhea, difficult menstruation." 3. " Sichuan Chinese medicinal herbal ": " controls cranial nerve and the heart, stomach is weak, and chronic off one's dot and urine collapses." 4. " Shaanxi Chinese medicinal herbal ": " controls cardiopalmus and lumbago." 5. " Shaanxi Chinese herbal medicine ": " calmness of calming the nerves, wind dispelling spasmolytic, promoting regeneration of the tissue and arresting bleeding, pain relieving.Control hysteria, Keshan disease, heart disease (myocarditis, post partum heart disease, rheumatic heart disease merge heart failure), lumbago and skelalgia, gastrointestinal convulsion, arthritis, traumatic injury, traumatic hemorrhage.″

Flos Chrysanthemi:

[meridian distribution of property and flavor] acrid in the mouth, sweet, hardship; Cold nature.Return lung, Liver Channel.

[function cures mainly] the wind heat clearing away of loosing, suppressing the hyperactive liver makes eye bright.Be used for anemopyretic cold, it is dizzy to have a headache, conjunctival congestion and swelling pain, and eyes is dim-sighted.

Fructus Foeniculi:

[meridian distribution of property and flavor] is warm in nature, acrid in the mouth.Return liver,kidney,spleen, stomach warp.

[function cures mainly] warming YANG to expel cold, regulating QI to relieve pain.Be used for colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.

Fructus Gardeniae:

[meridian distribution of property and flavor] hardship, cold.GUIXIN, lung, tri-jiao channel.

[function cures mainly] fruit: pathogenic fire purging relieving restlessness, clearing away heat and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.It is vexed to be used for calentura, the jaundice dark coloured urine, and blood strangury and dry pain, heat in blood is told nosebleed, conjunctival congestion and swelling pain, pathogenic fire,toxin and furuncles; External treatment bruise pain.Root: eliminating fire and detoxication, clearing away heat-damp and promoting diuresis, cool the blood dissipate blood stasis.Be used for infectious hepatitis, traumatic injury, acute toothache.

Rhizoma Chuanxiong:

[meridian distribution of property and flavor] suffering, temperature; Return liver, gallbladder, pericardium channel.

[function cures mainly] activating QI to alleviate the depression, the method wind-dryness is wet, promoting blood circulation and stopping pain.Control air-cooled headache and revolve dizzyly, the hypochondriac pain abdomen is painful, arthralgia due to cold clonic spasm of the muscle, amenorrhea, difficult labour, postpartum stagnation piece pain, ulcer sores.Be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Blood-activating and qi-promoting, wind-expelling pain-stopping. be used for menoxenia, amenorrhea dysmenorrhea, abdominal mass stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.

Fructus Lycii:

[meridian distribution of property and flavor] is sweet, and be flat, goes into liver, stomach two warps, doublely goes into lung meridian;

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, blood-enriching tranquillizing, promoting the production of body fluid to quench thirst, nourishing the lung to arrest cough.Cure mainly: it is dizzy to control apoplexy, and asthenia is allly seen blood disorder, cough blood, flaccidity, faint, contraction, the miasma that disappears is hindered dryly, passes out semen reddish and whitish turbid urine, beriberi, the arthroncus of knee.

Arillus Longan:

[meridian distribution of property and flavor] is sweet, temperature.Go into the heart, spleen channel.

[effect] heart tonifying and tranquilizing, strengthening the spleen nourishes blood.

Sweet in the mouth warm in nature, heart-spleen boosting fills blood; Have good nourishing benefiting action, 1, temperature compensation: child often catches a cold, and the body constitution cold caused by deficiency is often wet the bed, memory is not good, drinks Arillus Longan tea more and can promote mentality, improves cold caused by deficiency body constitution.2, breast enlargement: traditional Chinese medical science doctor says woman master's vim and vigour, often eats the woman of Arillus Longan, and is of pink and healthy-looking, with a full voluptuous figure, thus the benefit side of a lot of breast enlargements, all with Arillus Longan as collocation.3, sleep peacefully: the traditional Chinese medical science says that Arillus Longan has to calm the nerves and nourishes heart, enriches blood the effect of strengthening the spleen that it is edible to be fit to very much long-term insomniac.4, enrich blood: can improve cardiovascular circulation, stable mental status, alleviate pressure and anxiety, Arillus Longan contains and enriches glucose, sucrose, protein and multivitamin and trace element, and good nourishing benefiting action is arranged.Can be used for the weak after being ill or mental deterioration of treatment, the women transfers benefit also very suitable in puerperal.

Flos Osmanthi Fragrantis:

[meridian distribution of property and flavor] flower: suffering, temperature.Really: hot, sweet, temperature.Root: sweet, little puckery, flat.

[function cures mainly] flower: the broken knot of cold expelling, preventing phlegm from forming and stopping coughing.Be used for toothache, cough with asthma abundant expectoration, amenorrhea stomachache.Really: warming the stomach, suppressing the hyperactive liver, cold expelling.Be used for cold of insufficiency type and stomachache.Root: wind-damp dispelling, cold expelling.Be used for the rheumatism bones and muscles pain, lumbago, the toothache of suffering from a deficiency of the kidney.

Radix Ophiopogonis:

[meridian distribution of property and flavor] sweet, little hardship is slightly cold.GUIXIN, lung, stomach warp.

[function with cure mainly] YIN nourishing and the production of body fluid promoting, lung moistening clears away heart-fire.Be used for dryness of the lung dry cough, the chronic consumptive disease cough, Tianjin wound is thirsty, vexed insomnia, interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.

Mel:

[nature and flavor] are sweet;

[function] antibiotic antisepsis all has its antibacterial action to pathogenic bacterium such as escherichia coli, hemophilus influenza, streptococcus.

The invention provides a kind of Chinese medicine composition for the treatment of dysthymia, is to be made by the herbal raw material of following weight proportion:

Radix Salviae Miltiorrhizae 5-20 part, Radix Angelicae Sinensis 5-15 part, Ganoderma 1-8 part, Fructus Schisandrae Chinensis 3-10 part, Fructus Viticis 5-10 part, Herba Cistanches 5-10 part, Cortex Albiziae 5-20 part, Caulis Polygoni Multiflori 1-10 part, Fructus Momordicae charantiae 5-8 part, Fructus Mori 3-10 part, Semen Ziziphi Spinosae 3-10 part, Succus Bambusae 3-10 part, Rhizoma Zingiberis Recens 3-8 part, Rhizoma et radix valerianae 2-8 part, Flos Chrysanthemi 2-8 part, Flos Osmanthi Fragrantis 2-8 part, Fructus Foeniculi 1-6 part, Fructus Gardeniae 1-6 part, Rhizoma Chuanxiong 1-6 part, Fructus Lycii 5-10 part, Arillus Longan 5-10 part, Radix Ophiopogonis 3-8 part, Mel 3-8 part;

Preparation method is as follows:

1, get Rhizoma Zingiberis Recens, Fructus Mori acid, Semen Ziziphi Spinosae, Fructus Momordicae charantiae according to formula proportion and clean adding distil water and soaked 2 hours for 50～100 parts, wear into juice with fiberizer, be heated to and boil 10 minutes, filter and be cooled to room temperature, it is standby to make extracting solution after the purification;

2, pressing formula proportion cleans Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Ganoderma, Fructus Schisandrae Chinensis, Fructus Viticis, Herba Cistanches, Cortex Albiziae, Caulis Polygoni Multiflori, Rhizoma et radix valerianae, Flos Chrysanthemi, Flos Osmanthi Fragrantis, Fructus Foeniculi, Fructus Gardeniae, Rhizoma Chuanxiong, Fructus Lycii, Arillus Longan, Radix Ophiopogonis, putting into marmite boiled 15-20 minute in 150-180 ℃, extract supernatant and be cooled to room temperature (boil and carry three times), get boil for three times put on behind the clear liquid mix homogeneously standby;

3, extracting solution after will purifying in proportion and standby supernatant add Mel, Succus Bambusae and are in harmonious proportion evenly bottling, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and get product.

The invention provides a kind of Chinese medicine composition for the treatment of dysthymia, is to be made by the herbal raw material of following weight proportion:

Radix Salviae Miltiorrhizae 10-15 part, Radix Angelicae Sinensis 8-13 part, Ganoderma 3-6 part, Fructus Schisandrae Chinensis 5-8 part, Fructus Viticis 6-8 part, Herba Cistanches 6-8 part, Cortex Albiziae 10-15 part, Caulis Polygoni Multiflori 4-8 part, Fructus Momordicae charantiae 6.5-7.5 part, Fructus Mori 5-8 part, Semen Ziziphi Spinosae 5-8 part, Succus Bambusae 5-8 part, Rhizoma Zingiberis Recens 5-7 part, Rhizoma et radix valerianae 3-6 part, Flos Chrysanthemi 3-6 part, Flos Osmanthi Fragrantis 2-6 part, Fructus Foeniculi 2-5 part, Fructus Gardeniae 2-5 part, Rhizoma Chuanxiong 2-5 part, Fructus Lycii 6-8 part, Arillus Longan 6-8 part, Radix Ophiopogonis 5-7 part, Mel 5-7 part.

The invention provides a kind of Chinese medicine composition for the treatment of dysthymia, is to be made by the herbal raw material of following weight proportion:

12 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Angelicae Sinensis, 5 parts of Ganodermas, 7 parts of Fructus Schisandrae Chinensis, 7.5 parts of Fructus Viticises, 7.5 parts of Herba Cistanches, 12 parts of Cortex Albiziaes, 5.5 parts of Caulis Polygoni Multiflori, 7 parts in Fructus Momordicae charantiae, 7 parts in Fructus Mori, 7 parts of Semen Ziziphi Spinosaes, 7 parts of Succus Bambusaes, 6.5 parts in Rhizoma Zingiberis Recens, 4 parts of Rhizoma et radix valerianaes, 4 parts of Flos Chrysanthemis, 4 parts of Flos Osmanthi Fragrantis, 3 parts in Fructus Foeniculi, 3 parts of Fructus Gardeniaes, 3 parts of Rhizoma Chuanxiongs, 7.5 parts of Fructus Lycii, 7.5 parts of Arillus Longans, 6.5 parts of Radix Ophiopogonis, 6.5 parts of Mel.

The invention has the beneficial effects as follows: can calm the nerves relieving convulsion, Yin Yang balancing, conditioning viscera, nourishing brain cell, heat-clearing and toxic substances removing, eliminate phlegm for resuscitation, blood circulation promoting and blood stasis dispelling, strengthening vital QI to eliminate pathogenic factors, YIN nourishing nourishing the liver, invigorating the spleen and benefiting QI, tranquilizing by nourishing the heart.Make the comprehensive rehabilitation of nervous system, immune function of human body strengthens comprehensively, and the optimum state that nervous system is in balance of nature, stablize the coordinating and unifying stops to recur the purpose that reaches treating both the principal and secondary aspects of a disease.

The specific embodiment

Embodiment 1:

Prescription: Radix Salviae Miltiorrhizae 5g, Radix Angelicae Sinensis 5g, Ganoderma 1g, Fructus Schisandrae Chinensis 3g, Fructus Viticis 5g, Herba Cistanches 5g, Cortex Albiziae 5g, Caulis Polygoni Multiflori 1g, Fructus Momordicae charantiae 5g, Fructus Mori 3g, Semen Ziziphi Spinosae 3g, Succus Bambusae 3g, Rhizoma Zingiberis Recens 3g, Rhizoma et radix valerianae 2g, Flos Chrysanthemi 2g, Flos Osmanthi Fragrantis 2g, Fructus Foeniculi 1g, Fructus Gardeniae 1g, Rhizoma Chuanxiong 1g, Fructus Lycii 5g, Arillus Longan 5g, Radix Ophiopogonis 3g, Mel 3g;

Preparation method is as follows:

1, get Rhizoma Zingiberis Recens, Fructus Mori acid, Semen Ziziphi Spinosae, Fructus Momordicae charantiae according to formula proportion and clean adding distil water and soaked 2 hours for 50～100 parts, wear into juice with fiberizer, be heated to and boil 10 minutes, filter and be cooled to room temperature, it is standby to make extracting solution after the purification;

2, pressing formula proportion cleans Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Ganoderma, Fructus Schisandrae Chinensis, Fructus Viticis, Herba Cistanches, Cortex Albiziae, Caulis Polygoni Multiflori, Rhizoma et radix valerianae, Flos Chrysanthemi, Flos Osmanthi Fragrantis, Fructus Foeniculi, Fructus Gardeniae, Rhizoma Chuanxiong, Fructus Lycii, Arillus Longan, Radix Ophiopogonis, putting into marmite boiled 15-20 minute in 150-180 ℃, extract supernatant and be cooled to room temperature (boil and carry three times), get boil for three times put on behind the clear liquid mix homogeneously standby;

3, extracting solution after will purifying in proportion and standby supernatant add Mel, Succus Bambusae and are in harmonious proportion evenly bottling, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and get product.

Usage and dosage: each 5-10ml takes with the warm water dilution.

Embodiment 2:

Prescription: Radix Salviae Miltiorrhizae 10g, Radix Angelicae Sinensis 8g, Ganoderma 3g, Fructus Schisandrae Chinensis 5g, Fructus Viticis 6g, Herba Cistanches 6g, Cortex Albiziae 10g, Caulis Polygoni Multiflori 4g, Fructus Momordicae charantiae 6.5g, Fructus Mori 5g, Semen Ziziphi Spinosae 5g, Succus Bambusae 5g, Rhizoma Zingiberis Recens 5g, Rhizoma et radix valerianae 3g, Flos Chrysanthemi 3g, Flos Osmanthi Fragrantis 2g, Fructus Foeniculi 2g, Fructus Gardeniae 2g, Rhizoma Chuanxiong 2g, Fructus Lycii 6g, Arillus Longan 6g, Radix Ophiopogonis 5g, Mel 5g;

Preparation method is identical with embodiment 1.

Embodiment 3:

Prescription: Radix Salviae Miltiorrhizae 12g, Radix Angelicae Sinensis 10g, Ganoderma 5g, Fructus Schisandrae Chinensis 7g, Fructus Viticis 7.5g, Herba Cistanches 7.5g, Cortex Albiziae 12g, Caulis Polygoni Multiflori 5.5g, Fructus Momordicae charantiae 7g, Fructus Mori 7g, Semen Ziziphi Spinosae 7g, Succus Bambusae 7g, Rhizoma Zingiberis Recens 6.5g, Rhizoma et radix valerianae 4g, Flos Chrysanthemi 4g, Flos Osmanthi Fragrantis 4g, Fructus Foeniculi 3g, Fructus Gardeniae 3g, Rhizoma Chuanxiong 3g, Fructus Lycii 7.5g, Arillus Longan 7.5g, Radix Ophiopogonis 6.5g, Mel 6.5g;

Preparation method is identical with embodiment 1.

Embodiment 4:

Prescription: Radix Salviae Miltiorrhizae 15g, Radix Angelicae Sinensis 13g, Ganoderma 6g, Fructus Schisandrae Chinensis 8g, Fructus Viticis 8g, Herba Cistanches 8g, Cortex Albiziae 15g, Caulis Polygoni Multiflori 8g, Fructus Momordicae charantiae 7.5g, Fructus Mori 8g, Semen Ziziphi Spinosae 8g, Succus Bambusae 8g, Rhizoma Zingiberis Recens 7g, Rhizoma et radix valerianae 6g, Flos Chrysanthemi 6g, Flos Osmanthi Fragrantis 6g, Fructus Foeniculi 5g, Fructus Gardeniae 5g, Rhizoma Chuanxiong 5g, Fructus Lycii 8g, Arillus Longan 8g, Radix Ophiopogonis 7g, Mel 7g;

Preparation method is identical with embodiment 1.

Embodiment 5:

Prescription: Radix Salviae Miltiorrhizae 20g, Radix Angelicae Sinensis 15g, Ganoderma 8g, Fructus Schisandrae Chinensis 10g, Fructus Viticis 10g, Herba Cistanches 10g, Cortex Albiziae 20g, Caulis Polygoni Multiflori 10g, Fructus Momordicae charantiae 8g, Fructus Mori 10g, Semen Ziziphi Spinosae 10g, Succus Bambusae 10g, Rhizoma Zingiberis Recens 8g, Rhizoma et radix valerianae 8g, Flos Chrysanthemi 8g, Flos Osmanthi Fragrantis 8g, Fructus Foeniculi 6g, 6 parts of Fructus Gardeniaes, Rhizoma Chuanxiong 6g, Fructus Lycii 10g, Arillus Longan 10g, Radix Ophiopogonis 8g, Mel 8g;

Preparation method is identical with embodiment 1.

Therapeutic effect and curative effect:

Observation index:

Insomnia: long-term sleeping sleep again even only can sleep half an hour or tens minutes every night because of difficult, the back difficulty of can't fall asleep, easily wake up with a start, wake up, dizzy, health is weak, hypomnesis, early awakening, two threes of morning just can't fall asleep, and always thinks the thing that some are boring.

Depression: depressed, listless, feel depressed, world-wearyly commit suicide, word speed is slow, voice are low, the language amount less, motionless, the insomnia of bradykinesia, silence, bed, headache, dizzy, uncomfortable in chest, breathe hard, have palpitation, general weakness, constipation etc.

Frightened: to square, environment, other people, animal, object etc. strong frightened, see that a kind of thing can be had palpitation, trembles, perspired, dizziness in addition fall in a swoon, green around the gills etc.

Force: people one day is arranged otherwise washing one's hands of stopping has the people always to suspect whether door and window is shut, probably height is but jumped out from high housing-group, likes that child but abandons child from balcony, the people is arranged in addition force oneself count step, the ladder of jumping out of the building, several windows etc.

Neurosis, climacteric syndrome, hypochondriasis: total suspect own illly, check repeatedly, require treatment repeatedly, fidgety peace simultaneously, worries are felt bad, insomnia etc. endlessly.

Schizophrenia: auditory hallucination, hallucination, delusion of sin punish vain hope, nosomania, delusion of poverty, responsive suspicious, force impetuous, talking nonsense, fall thing, hit the person, swear at people, off one's feet etc.

The neurasthenia: insomnia, responsive, keep in dark place, be afraid of to disturb by making noise, feel dizzy, beat not rise spirit, absent minded, hypomnesis, easily fidgety, exciting, send out spleen, have palpitation, perspiration, diarrhoea, menoxenia, sexual impotence, premature ejaculation, night be can't fall asleep, beat and sleep daytime.

Anxiety: dysphoria, on tenterhooks, when ordinary person need not to worry fear, anxious, uneasy, worry that the patient is unable to explain clearly.Picture is shaken, felt all right to also dizziness often, insomnia, xerostomia, perspiration, nervous, uncomfortable in chest, headache, pale complexion, both hands at once will be in the dust, will be out of my mind, as if heart to jump out from the oral cavity, big mouthful breathe, make a scene, shout help etc.

9 kinds of evaluation criterias of depression:

1. social activity and human communication were all had no interest more than lasting two weeks.

2. health is obviously become thin or body weight obviously increases, and continues more than two weeks.

3. sleep disorder is arranged, often waken up with a start by bad dream, early morning, four or five early awakenings continued more than two weeks.

4. often irritated, be some minor matter quarrels, time remaining is more than two weeks.

5. slow movement is spoken slowly, continues more than two weeks.

6. often feel tired, even long-time bed, continue more than two weeks.

7. feel oneself to live to such an extent that be not worth, underestimation oneself, everything is self-doubt, continues for two weeks.

8. attention can not be concentrated, and is always absent-minded to what, and bradyphrenia continued for two weeks.

9. often expect that extremely the experience of injury oneself was arranged, attempt, continue more than two weeks from unsafe, adventurous condition process.

The cardinal symptom efficacy result is compared as follows:

Symptom	The example number	Recovery from illness	Produce effects	Effectively	Invalid	Total effective rate (routine %)
							Insomnia	17	16	10	16	1	16(99.00％)
Depression	43	31	5	4	3	40(93.20％)
							Frightened	19	12	2	3	2	17(89.47％)
The neurasthenia	82	40	18	21	3	79(96.34％)
							Anxiety	70	36	12	15	7	63(90.00％)
Neurosis, climacteric syndrome, hypochondriasis	74	35	14	20	5	69(93.24％)
							Force	85	46	11	24	4	81(92.92％)

Seven groups of average total effective rates reach 〉=93.45. as shown in the figure

Annotate: above-mentioned seven groups of treatment patients find no untoward reaction and toxic and side effects in whole clinical treatment observation process, liver, renal function do not have significant change, and it is effective to show that the present invention treats the safety of medicine of dysthymia.

Model case:

Case one:

The Wang is from little introverted, and timidity is bad at talk, is unwilling and other people contacts, and is unsocial.In in December, 05, studying in college one grade.Because of learning pressure causes psychological problem greatly, difficulty falling asleep, sometimes insomnia all night, the mental status occurs absent minded worse and worse then, hypomnesis, brain is slow in reacting, the thinking obturation, can not feel at ease last class hour to pay attention to the class, can't concentrate on, panesthesia's " brain is not very useful ", mood is often depressed, heavy, often cry alone, study feels unable to do what one wishes, and the thought of suicide is arranged, though reading every day surplus ten hour, produces little effect, school grade obviously descends, owing to be afraid of that the head of a family abuses, dare not say that the head of a family does not find the appearance of disease yet.The back state of an illness increases the weight of gradually, shows as fear, dysphoria, anxiety, anxiety, produces exciting emotion sometimes, quarrels with the classmate often, and classmate's relation is inharmonious.School notifies the head of a family to suspend schooling and is in and carries out systematic treating.The head of a family is with him to arrive local hospital, is diagnosed as depression, takes Western medicine Clomipramine and sulpiride, and the state of an illness take a favorable turn slightly, but after four months, and the state of an illness is shown effect once more, repeated multiple times like this, and therapeutic effect is not good.Took 3 months patient's emotions of medicament of the present invention and recover normal through introducing in 05 year, and successful drug withdrawal, the mental status is good at present, lives a regular life, and has recovered normal university life.

Case two:

72 years old this year of old lady Li was one to give spirit very good in the past, an old man loquacious, suddenly become closely over the past half year and do not like motion, slow in one's movements stiff, housework seldom needs just can finish for a long time, do not like initiatively speech yet, each all with brief low speech answer household.Facial expression is with low uncertainty, and eyes are stared sometimes, and trend is usually unmoved to external world, and only when mentioning the my old man that she dies, just Tears sparkled in one's eyes for she, said that many things oneself all can not do, and can not think how to do the brains blank out.The household thinks his heavy, thinks it is parkinson, old lady Li also often say oneself have uncomfortable, for example headache, dizziness, appetite depression, weight loss, unable, urgent micturition frequent micturition uncomfortable in chest, tired out or the like.But done a lot of check results all is normal.Through we check think that patient suffers from be: depression in old age.Because old man's age ratio is bigger, we have designed therapeutic scheme at old lady's Li symptom, and by taking medicament of the present invention half a year, it is normal that old lady's Li action recovers gradually, exchanges with the household and increase.Uncomfortable disappearance.

Case three:

Rhizoma Zingiberis Recens xx, be the undergraduate of domestic certain well-known university computer specialty, IT industry work was engaged in 2 years in Jinan in the graduation back, and obtained achievement preferably, be upgraded to certain project director, still can be competent at after promoting, in last Sep, company requires her to be responsible for two projects simultaneously, this moment patient to feel operating pressure big, begin insomnia, and the inter personal contact anxiety gradually occurs, too ready to suspect, feel that the colleague says her malicious remark behind, patient feels misery very much for this reason, so handed over letter of resignation to the higher level, originally think that the higher level can keep her, but the higher level has agreed her resignation.The back state of an illness of resigning further increases the weight of, and still all feeling in the street at home has the people to monitor her, and this moment, her lover felt that she has problem at spirit, go to a doctor so be with her to arrive local hospital psychiatric department, she is schizophrenia for a diagnosis, gives the olanzapine treatment, treated 2 months, the state of an illness does not have improvement.She is in 2 years, and what all can not done, and the household has walked a lot of places in order to cure the disease to him.After upon somebody's introduction, take preparation of the present invention three months with recovery from illness, the drug withdrawal heel was observed with 1 year, recurrence.

Case four:

Mr. Liu is the Marketing Manager of a company, leads the staff of his bottom, and it is very outstanding that business is done, and promoted by head office, is arranged into the another one city and is the general manager.Words according to Mr. Niu say that " mentioned powerful and influential position by boss suddenly, psychology has little time to prepare, and I just fall into into wrong path quickly! " leave familiar city, come strange city, he feels incompatible always, and the business of new town carries out and be not very smooth, has a hunch new subordinate in own gesticulating behind, pressure is very big.How Mr.'s Niu mood gradually is more irritated, and calculate " class of escaping " all day in the brain, and beginning is to be unwilling to contact with working together, increase the weight of gradually to being reluctant the suggestion people, and laziness, stay indoor every day at home, what done all have no stomach for.Coming our hospital diagnosis is: depression.We have formulated therapeutic scheme for him, at first adjust emotion by Drug therapy, formulated the daily schedule of science then, help him to establish confidence simultaneously, through the treatment of 3 courses of treatment, Mr. Niu recovers normally to have restarted work substantially, at this moment we have readjusted Therapeutic Method for him, carry out follow-up follow-up treatment.At present, Mr.'s Niu drug withdrawal 2 years, not recurrence, and the market development of his new town has surpassed the expectation of head office, has obtained the very high evaluation of head office.

Case five:

Liu xx, school grade is very outstanding all the time, and being admitted to university just becomes the cadre of students' union, but because personality is relatively more introversive, Xiao Liu is at when work wind scene light always, but be depressed privately, big two the time, he does not have the appearance insomnia of any reason, the beginning early awakening, the back difficulty falling asleep gradually occurs after quarrelling with friend owing to feel bad, once in a while sleeplessness all night, the self-induction dizziness and distending sensation of the head, hypomnesis, sometimes with cardiopalmus, uncomfortable in chest, feel hollow and boring, lassitude is reluctant to contact with the people all day, feels to feel oneself inferior very much.Once do many inspections to hospital and all do not find organic disease, take, Drug therapy such as west is many half a year, do not see to be clearly better that mood is depressed, heavy more, sometimes occur fidgety, depressed, the insomnia also even more serious, run into not happy event feelings sleeplessness all night, daytime is fatigue and weak especially, thinks that life is remote, life is meaningless, pessimistic and worldweary, want several times to commit suiside, situation is even more serious closely over the past half year.My institute afterwards, inspection is diagnosed as: depression, through 7 days treatment, clinical symptom disappearance, patient is very delight, again through the basic rehabilitation of 3 months treatment patients.Taken the medicine of 3 courses of treatment again in order to consolidate curative effect, recurrence is not seen in drug withdrawal now 2 years.Xiao Liu says happily: " now, I resemble and have changed a people, and I am again not shy, do not feel oneself inferior, and every day is all energetic, and is tricky, writes article such as natural and smooth, and speaking unceasingly in last dais, thanks you all! ".Xiao Liu has found a company to do translation at present.

Case six:

Miss Wu is a secondary school teachers, since in March, 2000, and her regular ground mental state depression, pessimism, anhedonia, energy goes down, and feels own incompetent, headache sometimes, somehow or other is feared, feels isolated, and it is meaningless to live, and the thought of committing suicide is arranged frequently.See five years old the son place of climbing, will associate him and can or can not fall that always think the situation that some are bad, as if in a word, anything has all become tragedy through brain at once.Sometimes suddenly unable, the strength that as if heart is hollow speaks does not all have, because health without any organic pathological changes, contrasts the feature of depression, knows and oneself has suffered from depression.Repeatedly go up hospitalizes such as Beijing, Shanghai, effect is not fine.Afterwards, world-weary emotion was more and more serious, expect several times committing suiside, but she also regarded as memory loved son.Introduce by friend, she recognizes our hospital, then get in touch with us, by linking up with doctor's phone repeatedly, the expert has left therapeutic scheme for him, take the medicine of two courses of treatment, just feel that mood is much better significantly, sleep also is greatly improved, after continuing to take 20 days, just had a headache never again, every day, sleep was all very steady and sure, and health also energetically.After adhering to again under guidance having taken two courses of treatment, all symptoms have all disappeared, and have heaved the courage of life again, have realized the fine of life, and work has also more been made great efforts.He says in giving doctor's letter: " be the life that you have saved me, saved my family, allow my life be full of enjoyment ".He has come back to sacred dais now.

Claims (3)

1. Chinese medicine composition for the treatment of dysthymia, it is characterized in that, be to be made by the herbal raw material of following weight proportion: Radix Salviae Miltiorrhizae 5-20 part, Radix Angelicae Sinensis 5-15 part, Ganoderma 1-8 part, Fructus Schisandrae Chinensis 3-10 part, Fructus Viticis 5-10 part, Herba Cistanches 5-10 part, Cortex Albiziae 5-20 part, Caulis Polygoni Multiflori 1-10 part, Fructus Momordicae charantiae 5-8 part, Fructus Mori 3-10 part, Semen Ziziphi Spinosae 3-10 part, Succus Bambusae 3-10 part, Rhizoma Zingiberis Recens 3-8 part, Rhizoma et radix valerianae 2-8 part, Flos Chrysanthemi 2-8 part, Flos Osmanthi Fragrantis 2-8 part, Fructus Foeniculi 1-6 part, Fructus Gardeniae 1-6 part, Rhizoma Chuanxiong 1-6 part, Fructus Lycii 5-10 part, Arillus Longan 5-10 part, Radix Ophiopogonis 3-8 part, Mel 3-8 part;

Preparation method is as follows:

(1), get Rhizoma Zingiberis Recens, Fructus Mori, Semen Ziziphi Spinosae, Fructus Momordicae charantiae according to formula proportion and clean adding distil water and soaked 2 hours for 50～100 parts, wear into juice with fiberizer, be heated to and boil 10 minutes, filter and be cooled to room temperature, it is standby to make extracting solution after the purification;

(2), pressing formula proportion cleans Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Ganoderma, Fructus Schisandrae Chinensis, Fructus Viticis, Herba Cistanches, Cortex Albiziae, Caulis Polygoni Multiflori, Rhizoma et radix valerianae, Flos Chrysanthemi, Flos Osmanthi Fragrantis, Fructus Foeniculi, Fructus Gardeniae, Rhizoma Chuanxiong, Fructus Lycii, Arillus Longan, Radix Ophiopogonis, putting into marmite boiled 15-20 minute in 150-180 ℃, extract supernatant and be cooled to room temperature, boil and carry three times, get boil for three times put on behind the clear liquid mix homogeneously standby;

(3), in proportion the extracting solution after will purifying and standby supernatant add Mel, Succus Bambusae and are in harmonious proportion evenly bottling, place the disinfecting container of high temperature 〉=100 ℃ to carry out disinfection, and get product.

2. a kind of Chinese medicine composition for the treatment of dysthymia according to claim 1, it is characterized in that, be to be made by the herbal raw material of following weight proportion: Radix Salviae Miltiorrhizae 10-15 part, Radix Angelicae Sinensis 8-13 part, Ganoderma 3-6 part, Fructus Schisandrae Chinensis 5-8 part, Fructus Viticis 6-8 part, Herba Cistanches 6-8 part, Cortex Albiziae 10-15 part, Caulis Polygoni Multiflori 4-8 part, Fructus Momordicae charantiae 6.5-7.5 part, Fructus Mori 5-8 part, Semen Ziziphi Spinosae 5-8 part, Succus Bambusae 5-8 part, Rhizoma Zingiberis Recens 5-7 part, Rhizoma et radix valerianae 3-6 part, Flos Chrysanthemi 3-6 part, Flos Osmanthi Fragrantis 2-6 part, Fructus Foeniculi 2-5 part, Fructus Gardeniae 2-5 part, Rhizoma Chuanxiong 2-5 part, Fructus Lycii 6-8 part, Arillus Longan 6-8 part, Radix Ophiopogonis 5-7 part, Mel 5-7 part.

3. a kind of Chinese medicine composition for the treatment of dysthymia according to claim 2, its feature also is, is to be made by the herbal raw material of following weight proportion: 12 parts of Radix Salviae Miltiorrhizaes, 10 parts of Radix Angelicae Sinensis, 5 parts of Ganodermas, 7 parts of Fructus Schisandrae Chinensis, 7.5 parts of Fructus Viticises, 7.5 parts of Herba Cistanches, 12 parts of Cortex Albiziaes, 5.5 parts of Caulis Polygoni Multiflori, 7 parts in Fructus Momordicae charantiae, 7 parts in Fructus Mori, 7 parts of Semen Ziziphi Spinosaes, 7 parts of Succus Bambusaes, 6.5 parts in Rhizoma Zingiberis Recens, 4 parts of Rhizoma et radix valerianaes, 4 parts of Flos Chrysanthemis, 4 parts of Flos Osmanthi Fragrantis, 3 parts in Fructus Foeniculi, 3 parts of Fructus Gardeniaes, 3 parts of Rhizoma Chuanxiongs, 7.5 parts of Fructus Lycii, 7.5 parts of Arillus Longans, 6.5 parts of Radix Ophiopogonis, 6.5 parts of Mel.