CN105999049A

CN105999049A - Traditional Chinese medicine composition for treating chronic renal failure and complications thereof

Info

Publication number: CN105999049A
Application number: CN201610317541.6A
Authority: CN
Inventors: 孔玉科; 孔令瑞; 杜轩
Original assignee: Individual
Current assignee: Kong Yuke
Priority date: 2016-05-13
Filing date: 2016-05-13
Publication date: 2016-10-12
Anticipated expiration: 2036-05-13
Also published as: CN105999049B

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic renal failure and complications thereof. The traditional Chinese medicine composition is prepared from parched hawthorn fruits, parched pericarpium citri reticulatae, radix angelica sinensis, parched radix paeoniae alba, fructus aurantii parched with bran, pericarpium citri reticulatae viride, radix paeoniae rubra, flos carthami, periostracum cicada, raw radix astragalis, rhizoma curcumae parched with aged vinegar, rhizoma chuanxiong, parched cowherb seeds, rhizoma sparganii parched with aged vinegar, Chinese magnoliavine fruits baked with honey, herb of snow of June, ginseng, prepared radix et rhizoma rhei, honey-fried licorice roots, rhizoma atractylodis macrocephalae parched with soil, rhizoma smilacis glabrae, cassia twigs, leeches, eupolyphaga sinensis and lumbricus. According to the traditional Chinese medicine composition, 25 traditional Chinese medicine materials are carefully selected based on the treatment principles of mainly treating root causes, combining symptoms with root causes, strengthening the body resistance to eliminate pathogenic factors and coordinating yin and yang and have the effects of strengthening the spleen and benefiting qi, stimulating menstrual flow and activating blood circulation, removing damp turbidity toxins, and nourishing the lung, chronic renal failure and uremia can be rapidly and effectively treated, and experiments show that the effective rate of the traditional Chinese medicine composition on uremia reaches 70% or above.

Description

A kind of Chinese medicine composition treated chronic renal failure and cause disease

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition treated chronic renal failure and cause disease Thing.

Background technology

Chronic kidney disease sickness rate presents a rapidly rising trend in the world, and poor prognosis, medical expense is high, becomes Worldwide public health problem.Chronic renal failure is to be in progress by various constitutionales and subsequent chronic nephropathy Progressive symmetric erythrokeratodermia The excess of the kidney matter serious damage caused, causes with metabolite and poisonous substance retention, water, electrolyte and acid base imbalance and interior point Secreting the clinical syndrome that imbalance is characterized, it generally proceeds to end stagerenaldisease, is also called uremia.End-stage Renal Disease Patients face Face high admission rate, high mortality and the risk of great number medical expense.

At present, the effective scheme for the treatment of chronic kidney disease is Comprehensive Treatment, including controlling protopathy, nutrition and life style Intervene, actively control complication；The effective scheme for the treatment of end stagerenaldisease is Renal replacement, saturating including hemodialysis, peritoneum Analysis and renal transplantation.Although the treatment for chronic renal failure of carrying out of hemodialysis, peritoneal dialysis and renal transplantation opens new way Footpath, extends the life of patient, but exist costly, kidney source is not enough and the problem of various complication, in developing country still Cannot popularize, many patients cannot obtain medical treatment, so seeking cheap medicine is the master that medical personal studies Want direction.

The traditional Chinese medical science is thought, chronic renal failure is with weakened body resistance for this, and the domination of pathogen is mark, belongs to the time of simulataneous insufficiency and excessive, is the weight of deficiency in origin and excess in superficiality Disease.The weakened body resistance decline of kidney-YANG that refers to, spleen sun loses, and kidney yin is exhausted, excessive rising of liver-YANG finally involves the vital organs of the human body；The domination of pathogen is mainly water Poison turbid damp, fills the air three Jiao, and causing stagnation of QI-blood is trouble.This disease pathogenesis change complexity, with the passing of time, accumulation whole body is multiple dirty in pathological changes delay Internal organs, in whole pathological process, spleen suffer from a deficiency of the kidney decline, noxious water turbid damp is the key of pathogenesis, turbid damp, blood stasis be through disease all the time it Pathogenic factor, conscience spleen kidney is the main portions of infringement.In consideration of it, treatment by Chinese herbs chronic renal failure and uremic research are the most active, And develop the Chinese medicine composition of various compositional difference.Chronic renal failure is treated as patent CN 102895551 A discloses one Chinese medicine, this Chinese medicinal components include Rhizoma Polygonati Odorati 10 parts, Radix Polygoni Multiflori 8 parts, the Radix Paeoniae Alba 14 parts, Radix Morindae Officinalis 5 parts, Semen Cuscutae 6 parts, the Cortex Eucommiae 8 parts, 3 parts of Cornu Cervi Pantotrichum, Pericarpium Citri Reticulatae 12 parts, Radix Bupleuri 9 parts, Radix Codonopsis 8 parts, the Radix Astragali 12 parts, Rhizoma Dioscoreae 14 parts, Mel 15 parts, Rhizoma Imperatae 8 parts, Rhizoma Polygonati 10 Part, Flos Lonicerae 10 parts, Periostracum Cicadae 14 parts；CN 1895631 A discloses one and treats uremic Chinese medicine, and this medicine component includes Huang Stilbene, Ramulus Uncariae Cum Uncis, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Radix Rehmanniae Preparata, Flos Chrysanthemi, Ramulus Mori, Herba Ephedrae, Semen Celosiae, Fructus Leonuri, Rhizoma Chuanxiong, Spica Prunellae, Cortex Eucommiae (parched), Radix Dipsaci, Rhizoma Dioscoreae, Radix Et Rhizoma Rhei (processed), Haematitum, Radix Ginseng, stir-fry Semen Trichosanthis, Herba Artemisiae Scopariae etc..All reports described above are a lot.But, existing treatment chronic renal Yet suffering from many deficiencies in sick medicine, as added expensive Chinese crude drug, drug component does not carries out pretreatment, and drug effect is difficult To play completely, and then cause treatment speed slow, the problems such as curative effect is the most notable.

Summary of the invention

It is an object of the invention to: a kind of Chinese medicine composition treated chronic renal failure and cause disease is provided, uses bran Fructus Aurantii (parched), fry Wang Buliu, 25 taste Chinese crude drug processing such as Rhizoma Curcumae and Rhizoma Sparganii fried by processed with honey Fructus Schisandrae Chinensis, wine army, Rhizoma Atractylodis Macrocephalae (parched with earth) and old vinegar Make.This medicine is based on originally, and specimen combines, and righting is got rid of evils, and coordinating YIN and YANG is Therapeutic Principle, quickly, effectively treats chronic kidney hypofunction The uremia exhausted and cause.

To achieve these goals, the present invention adopts the following technical scheme that

A kind of Chinese medicine composition treated chronic renal failure and cause disease, it is characterised in that: by the medicine of following weight portion Material is processed into: Fructus Crataegi (parched) 4～8 parts, fry Pericarpium Citri Reticulatae 4～8 parts, Radix Angelicae Sinensis 4～8 parts, Radix Paeoniae Alba (parched) 4～8 parts, stir-baked Fructus Aurantii in bran 3～7 parts, Pericarpium Citri Reticulatae Viride 3～7 parts, Radix Paeoniae Rubra 4～8 parts, Flos Carthami 1～5 parts, Periostracum Cicadae 1～5 parts, Radix Astragali 25～35 parts, old vinegar stir-fry Rhizoma Curcumae 4～8 Part, Rhizoma Chuanxiong 4～8 parts, stir-fry king do not stay 1～5 part, old vinegar stir-fry Rhizoma Sparganii 1～5 parts, processed with honey Fructus Schisandrae Chinensis 7～12 parts, Serissa foetida 4～8 Part, Radix Ginseng 3～7 parts, wine army 4～8 parts, Radix Glycyrrhizae Preparata 3～7 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 4～8 parts, Rhizoma Smilacis Glabrae 4～8 parts, Ramulus Cinnamomi 4～8 parts, Hirudo 4～8 parts, Eupolyphaga seu steleophaga 1～5 parts, Pheretima 1～5 parts.

As preferably, described a kind of Chinese medicine composition treated chronic renal failure and cause disease, it is characterised in that: by The processing of crude drugs of following weight portion is made: Fructus Crataegi (parched) 5～7 parts, stir-fry Pericarpium Citri Reticulatae 5～7 parts, Radix Angelicae Sinensis 5～7 parts, Radix Paeoniae Alba (parched) 5～7 parts, bran Fructus Aurantii (parched) 4～6 parts, Pericarpium Citri Reticulatae Viride 4～6 parts, Radix Paeoniae Rubra 5～7 parts, Flos Carthami 2～4 parts, Periostracum Cicadae 2～4 parts, Radix Astragali 28～32 parts, Lao Chen Rhizoma Curcumae Phaeocaulis (parched with vineger) 5～7 parts, Rhizoma Chuanxiong 5～7 parts, fry king do not stay 2～4 parts, old vinegar fry Rhizoma Sparganii 2～4 parts, processed with honey Fructus Schisandrae Chinensis 8～10 Part, Serissa foetida 5～7 parts, Radix Ginseng 4～6 parts, wine army 5～7 parts, Radix Glycyrrhizae Preparata 4～6 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 5～7 parts, Rhizoma Smilacis Glabrae 5～7 Part, Ramulus Cinnamomi 5～7 parts, Hirudo 5～7 parts, Eupolyphaga seu steleophaga 2～4 parts, Pheretima 2～4 parts.

As preferably, described a kind of Chinese medicine composition treated chronic renal failure and cause disease, it is characterised in that: by The processing of crude drugs of following weight portion is made: Fructus Crataegi (parched) 6 parts, stir-fry Pericarpium Citri Reticulatae 6 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Alba (parched) 6 parts, stir-baked Fructus Aurantii in bran 5 parts, green grass or young crops Skin 5 parts, Radix Paeoniae Rubra 6 parts, 3 parts of Flos Carthami, Periostracum Cicadae 3 parts, Radix Astragali 30 parts, old vinegar fry Rhizoma Curcumae 6 parts, Rhizoma Chuanxiong 6 parts, fry king do not stay 3 parts, Old vinegar fries Rhizoma Sparganii 3 parts, processed with honey Fructus Schisandrae Chinensis 9 parts, Serissa foetida 6 parts, Radix Ginseng 5 parts, wine army 6 parts, Radix Glycyrrhizae Preparata 5 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 6 Part, Rhizoma Smilacis Glabrae 6 parts, Ramulus Cinnamomi 6 parts, Hirudo 6 parts, Eupolyphaga seu steleophaga 3 parts, Pheretima 3 parts.

Prescription of the present invention former medicine effect and pharmacology:

Fructus Crataegi: slightly warm in nature, nontoxic, sour in the mouth, sweet, return spleen channel, stomach warp, Liver Channel, lung meridian.Have help digestion long-pending, change the merit of the stagnant stasis of blood Effect, cures mainly the diseases such as eating accumulation, abdominal distention, dysentery, dysmenorrhea due to blood stasis, amenorrhea, puerperal abdonimal pain, lochiorrhea.

Pericarpium Citri Reticulatae: warm in nature, bitter in the mouth, pungent, return lung, spleen channel.There is regulating qi-flowing for strengthening spleen, effect of drying dampness to eliminate phlegm, for fullness in the epigastrium and chest, Lack of appetite and vomiting, the disease such as cough with copious phlegm.

Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent, return liver, the heart, spleen channel.There is replenishing and activating blood, menstruction regulating and pain relieving, effect of loosening bowel to relieve constipation, For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, The diseases such as ulcer sores.

The Radix Paeoniae Alba: cold nature, bitter in the mouth, acid, return liver, spleen channel.There is suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating, use In headache dizziness, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, the disease such as night sweat.

Fructus Aurantii: warm in nature, bitter in the mouth, pungent, sour, return spleen, stomach warp, there is regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row, coerce gas for breast Stagnant, distension pain, accumulation of food in the stomach and intes tine due to indigestion, stops in phlegm retention；Gastroptosis, proctoptosis, the disease such as sub-official's prolapsus.

Pericarpium Citri Reticulatae Viride: warm in nature, bitter in the mouth, pungent, return liver, gallbladder, stomach warp.There is soothing the liver dispelling the stagnated QI, the effects such as removing food stagnancyization is stagnant, swollen for the breast side of body Bitterly, hernia, nodule in the breast, acute mastitis, the disease such as abdominal pain due to retention of food.

Radix Paeoniae Rubra: cold nature, bitter in the mouth, return Liver Channel.There is clearing away heat and cooling blood, effect of eliminating stasis to stop pain, for maculae caused by violent heat pathogen, spit blood Epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen suffers from abdominal pain, injury from falling down, the disease such as carbuncle skin infection.

Flos Carthami: warm in nature, acrid in the mouth, GUIXIN, Liver Channel.There is promoting blood circulation to restore menstrual flow, effect of eliminating stasis to stop pain, for amenorrhea, dysmenorrhea, dislike Revealing not all right, lump in the abdomen mass in the abdomen, injury from falling down, skin infection such as swells and ache the disease.

Periostracum Cicadae: cold in nature, sweet in the mouth, return liver, lung meridian.There is scattered wind heat, lung qi dispersing, determine convulsion effect.Modern pharmacological research shows: Cicadae Clothing has convulsion, calmness, reduction striped muscle tensity block nerves joint to release bronchial muscular spasm, has antiallergic Deng effect.For treating anemopyretic cold, aphonia, cough-relieving, controlling the diseases such as deaf, treatment insomnia and treatment allergic rhinitis.

The Radix Astragali: warm in nature, sweet in the mouth, return lung, spleen channel.There is invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation, use Weak in the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle difficulty is burst, for a long time Bursting and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, the disease such as diabetes.

Rhizoma Curcumae: warm in nature, acrid in the mouth, hardship, return liver, spleen channel.There is circulation of qi promoting removing blood stasis, effect of removing food stagnancy pain relieving, for abdominal mass mass in the abdomen, Blood stasis amenorrhea, food stagnation distending pain；The diseases such as early cervical carcinoma.

Rhizoma Chuanxiong: warm in nature, acrid in the mouth, return liver, gallbladder, pericardium channel.There is blood-activating and qi-promoting, effect of wind-expelling pain-stopping.For menstruation not The diseases such as adjusting, amenorrhea dysmenorrhea, lump in the abdomen is suffered from abdominal pain, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.

King does not stays: property is put down, and bitter in the mouth enters liver, stomach warp.There is promoting blood circulation to restore menstrual flow, effect of stimulating milk secretion detumescence, cure mainly blood stasis amenorrhea, Dysmenorrhea, difficult labour；Lack of lactation after delivery, acute mastitis swells and ache；Pyretic stranguria, stranguria with blood, the disease such as stranguria caused by urinary stone.

Rhizoma Sparganii: property is put down, bitter in the mouth returns liver, spleen channel.Having removing blood stasis circulation of qi promoting, effect of removing food stagnancy pain relieving, for lump in the abdomen mass in the abdomen, bitterly Warp, blood stasis amenorrhea, obstruction of qi in the chest and cardialgia, the disease such as food stagnation distending pain.

Fructus Schisandrae Chinensis: warm in nature, sour in the mouth, sweet, return lung, the heart, kidney channel.There is convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the merit of kidney calming Effect.For chronic cough dyspnea due to deficiency, emission, enuresis frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, and deficient pulse of losing heart, interior-heat disappears Yearningly, the disease such as palpitation and insomnia.

Serissa foetida: cool in nature, light, micro-pungent.There is the diseases such as soothing liver-QI for relieving depression, clearing away heat-damp and promoting diuresis, detumescence and drawing out poison, relieving cough and resolving phlegm, be used for Acute hepatitis, lumbago, skelalgia of rheumatism, carbuncle malignant boil, venom, diarrhea due to hypofunction of the spleen, infantile malnutrition, leukorrheal diseases, corneal nebula, acute appendicitis, rabies Deng disease.

Radix Ginseng: property is put down, sweet in the mouth, micro-hardship return spleen, lung, heart channel.Having strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, The effect calmed the nerves, for weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, and prolonged illness is empty Thin, palpitation with fear insomnia, sexual impotence cold womb；Heart failure, cardiogenic stops the disease such as g.

Wine army: have another name called Radix Et Rhizoma Rhei, cold in nature, bitter in the mouth, return spleen, stomach, large intestine, liver, pericardium channel.There is purging heat and dredging bowels, removing heat from blood solution Poison, effect of eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, Abdominalgia with intestinal abscess, carbuncle furuncle, blood stasis amenorrhea, traumatic injury, external treatment burn due to hot liquid or fire；Upper gastrointestinal hemorrhage.

Radix Glycyrrhizae: property is put down, sweet in the mouth, GUIXIN, lung, spleen, stomach warp.Having invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, emergency is only Bitterly, effect of coordinating the actions of various ingredients in a prescription, for weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity contraction urgency pain, Carbuncle sore tumefacting virus, cushion toxicity, strong.

The Rhizoma Atractylodis Macrocephalae: warm in nature, bitter in the mouth, sweet, return spleen, stomach warp.There is invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, the effect such as antiabortive.With In insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis Macrocephalae spleen invigorating, stomach function regulating, antiabortive.For insufficiency of the spleen Lack of appetite, loose stool of having loose bowels, frequent fetal movement.

Poria: property is put down, sweet in the mouth, light, GUIXIN, lung, spleen, kidney channel.There is the effects such as promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, for water Swell oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, and have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Ramulus Cinnamomi: warm in nature, acrid in the mouth, sweet, GUIXIN, lung, bladder warp.There is diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, flat punching Effect of sending down the abnormal ascending QI.For anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus, renal mass.

Hirudo: salty in the mouth, hardship, property is put down, slightly poisonous, returns Liver Channel.Having removing blood stasis, removing blood stasis, the effect stimulated the menstrual flow, for lump in the abdomen painful abdominal mass Block, blood stasis amenorrhea, injury from falling down.

Eupolyphaga seu steleophaga: the effect such as there is removing blood stasis, removing mass, dredging collateral, reason wound and reunion of bone, reducing swelling and alleviating pain, stimulating milk secretion are stimulated the menstrual flow, be Treating blood disorders traumatology key medicine, it is adaptable to the diseases such as the accumulation of cancer abdominal mass, amenorrhea due to stagnation of blood, postnatal blood stasis stomachache, traumatic injury, swollen and rigid tongue, congenital deformity of the tongue.

Pheretima: cold in nature, salty in the mouth, return liver, spleen, bladder warp.There is heat clearing away arresting convulsion, dredging collateral, relieving asthma, effect of diuresis, it is used for Unconsciousness due to high fever, infantile convulsion tic, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.

Side's medicine of the present invention uses the Therapeutic Principle of " based on originally, specimen combines, and righting is got rid of evils, coordinating YIN and YANG ", selects people The strengthening vital QI to eliminate pathogenic factors such as ginseng, the Radix Astragali, Fructus Crataegi are eliminated, to reach the effect of invigorating the spleen and benefiting QI；Turbid general three hand over time control turbid dampness removing of dispelling so that turbid damp from Defecate and go out, quickly and effectively treat chronic renal failure.

After it should be noted that said medicine raw material is by described weight portion co-grinding, add customary adjuvant, can be made into and appoint What a kind of conventional peroral dosage form, such as pill, tablet, oral liquid, capsule etc..

Compared with prior art, the beneficial effects of the present invention is:

1) present invention uses the Therapeutic Principle of " based on originally, specimen combines, and righting is got rid of evils, coordinating YIN and YANG ", selected 25 tastes Chinese crude drug invigorating the spleen and benefiting QI, restore menstrual flow and invigorate blood circulation, dispel the poison of turbid damp, nourish the bottom of heart, quickly, effectively treatment chronic renal failure and uremic Disease, test shows, this medicine reaches more than 70% to uremic effective percentage.

2) present invention carries out Preparation process to former medicine, changes or reduces toxic chemicals, thus reduce toxicity, obtundent Property, eliminate side effect, heighten the effect of a treatment.

3) former medicine selected by Chinese medicine composition of the present invention is all common Chinese medicine material, cheap, alleviates patient's economic pressures.

Detailed description of the invention

Below in conjunction with detailed description of the invention, technical scheme is described further, in order to same domain technology people The understanding of member.

Embodiment 1

A kind of Chinese medicine composition treated chronic renal failure and cause disease, is made up of the processing of crude drugs of following weight portion: Fructus Crataegi (parched) 6kg, stir-fry Pericarpium Citri Reticulatae 6kg, Radix Angelicae Sinensis 6kg, Radix Paeoniae Alba (parched) 6kg, stir-baked Fructus Aurantii in bran 5kg, Pericarpium Citri Reticulatae Viride 5kg, Radix Paeoniae Rubra 6kg, Flos Carthami 3kg, Cicadae Clothing 3kg, Radix Astragali 30kg, old vinegar stir-fry Rhizoma Curcumae 6kg, Rhizoma Chuanxiong 6kg, stir-fry king do not stay 3kg, old vinegar to fry Rhizoma Sparganii 3kg, the processed with honey five tastes Sub-9kg, Serissa foetida 6kg, Radix Ginseng 5kg, wine army 6kg, Radix Glycyrrhizae Preparata 5kg, Rhizoma Atractylodis Macrocephalae (parched with earth) 6kg, Rhizoma Smilacis Glabrae 6kg, Ramulus Cinnamomi 6kg, Hirudo 6kg, Eupolyphaga seu steleophaga 3kg, Pheretima 3kg.

Said medicine raw material, by after described weight portion co-grinding, adds and is equivalent to its gross weight 8～12 times of water, mild and heavy respiration Decoct 30～40 minutes, filter and collect filtrate；Adding in medicinal residues and be equivalent to its gross weight 5～8 times of water, mild and heavy respiration decocts 20～30 minutes, filter and collect filtrate；The filtrate of twice collection is merged, after stirring, adds customary adjuvant and make ball Agent.

Following example all use this area conventional means processing and fabricating, and difference is: this medicine raw material dosage is Difference, concrete consumption is as shown in table 1 below.

Table 1-treatment chronic renal failure and the Chinese medicine composition crude drug consumption of initiation disease thereof

	Embodiment	Embodiment	Embodiment	Embodiment
					Fructus Crataegi (parched), kg	4	5	7	8
Fry Pericarpium Citri Reticulatae, kg	4	5	7	8
					Radix Angelicae Sinensis, kg	4	5	7	8
Radix Paeoniae Alba (parched), kg	4	5	7	8
					Stir-baked Fructus Aurantii in bran, kg	3	4	6	7
Pericarpium Citri Reticulatae Viride, kg	3	4	6	7
					Radix Paeoniae Rubra, kg	4	5	7	8
Flos Carthami, kg	1	2	4	5
					Periostracum Cicadae, kg	1	2	4	5
Radix Astragali, kg	25	28	32	35
					Old vinegar fries Rhizoma Curcumae, kg	4	5	7	8
Rhizoma Chuanxiong, kg	4	5	7	8
					Fry Wang Buliu, kg	1	2	4	5
Old vinegar fries Rhizoma Sparganii, kg	1	2	4	5
					Processed with honey Fructus Schisandrae Chinensis, kg	7	8	10	12
Serissa foetida, kg	4	5	7	8
					Radix Ginseng, kg	3	4	6	7
Wine army, kg	4	5	7	8
					Radix Glycyrrhizae Preparata, kg	3	4	6	7
Rhizoma Atractylodis Macrocephalae (parched with earth), kg	4	5	7	8
					Rhizoma Smilacis Glabrae, kg	4	5	7	8
Ramulus Cinnamomi, kg	4	5	7	8
					Hirudo, kg	4	5	7	8
Eupolyphaga seu steleophaga, kg	1	2	4	5
					Pheretima, kg	1	2	4	5

In order to verify the actual efficacy of Chinese medicine composition of the present invention, it is explained below in conjunction with clinical trial.

1, clinical data and method

1.1 clinical datas: all case CRF patients both from December 4 days to 2015 January in 2015 29 days in Lanzhou The trouble that the second hospital of university, No.1 Hospital of Lanzhou University and the People's Hospital's outpatient service of Linxia, Gansu Province autonomous prefecture and in-patient department are gone to a doctor Person, is divided into two groups by medical order:

Treatment group: 84 examples, male 37 examples, female 47 example；Year mean age (59.8 ± 21.6)；Wherein primary chronic glomerule Nephritis 29 example, subsequent chronic glomerulonephritis 17 example, diabetic nephropathy 19 example, hypertensive nephropathy 14 example, polycystic kidney 5 example.

Matched group: 68 examples, man's 3l example, female 37 example；Year mean age (61.4 ± 19.7)；Wherein chronic glomerulonephritis 23 Example, subsequent chronic glomerulonephritis 16 example, diabetic nephropathy 18 example, hypertensive nephropathy 9 example, polycystic kidney disease: 2 cases.

Case source, Sex distribution ratio, age distribution ratio, protopathy distribution proportion, TCM Syndrome Type before two groups of treatments Distribution and renal function equal no difference of science of statistics (P > 0.05) by stages.

1.2 diagnostic criterias, include in and exclusion standard

1.2.1 TCM syndrome diagnostic criteria: according to China Medical Science Press in 2002 publish " new Chinese medicine I faces Bed research guideline " (see below literary composition adnexa) carry out differentiation of symptoms and signs for classification of syndrome, be divided into Pishenqixu syndrome, syndrome of yang deficiency of spleen and kidney, syndrome of yin deficiency of liver and kidney, 4 pattern of syndrome of deficiency syndrome of both YIN and YANG.

1.2.2 Western medicine diagnose standard and by stages: with reference in 2000 " chronic kidney disease clinical practice guideline " about chronic Nephropathy (CKD) definition and staging scale, the chronic renal failure that this institute is included in refers mainly to CKD3 to CKD5 phase patient.

1.2.3 inclusive criteria: 1. meet diagnosis and three diagnostic criterias by stages of Syndrome Differentiation of Traditional Chinese Medicine, protopathy and CKD； 2. infection, acidosis, electrolyte disturbance, hypertension etc. are controlled effectively；3. patient can take medicine on request, strictly controls drink Food, compliance is good, and the course of disease is more than 3 months, more than 1 month treatment time.

1.2.4 exclusion standard: 1. the age is less than 18 years old, more than 80 years old person；2. gestation or women breast-feeding their children；3. protopathy is The diseases related renal damage caused of the malignant diseases such as tumor；4. the preferable person of Renal function in early period before the state of an illness is CKD2 (containing)；⑤ Merge severe cardiac, liver, hemopoietic, neurological complication person and to drug allergy person；6. compliance is poor, it is impossible to by the regulation clothes course for the treatment of Medicine；7. get rid of researcher and think that other these tests cannot intolerant patient.

1.3 treatment and Experiment intervention methods: two groups of patients all use chronic renal insufficiency conventional therapy, and be careful in one's diet tune Protecting, give high-quality low protein diet, albumen intake is 0.6～0.89 (kg d)^-1, low-phosphorous diet also gives enough heat Amount, corrects water, electrolyte and acid base imbalance simultaneously, and preventing and treating is infected, had patient compliance's antihypertensive drug therapy of hypertension, power Strive controlling of blood pressure at below 140/90mmHg, it is to avoid use and affect renal function and have the medicine of nephrotoxicity.

Treatment group: on the basis of conventional therapy, takes Chinese medicine composition of the present invention.

Matched group: on the basis of conventional therapy, takes NIAODUQING KELI (Kang Chen Pharmaceutical produces, Sugarless type) each Bag, four times a day, electuary is administered orally.

1.4 research observation index: before and after the treatment of all cases, MAIN OUTCOME MEASURES is: TCM symptom score, hemoglobin (HGB), (all data are joined for erythrocyte (RBC), urine protein, ERY, serum creatinine (Scr), blood urea nitrogen (BUN), serum ion Examine value all with Lanzhou University's the second hospital laboratory parameter as foundation).

1.5 statistical procedures: with SPSS 10.0 software data processing.All measurement datas all use (x ± s) to represent, group Between and treatment before and after compare employing t inspection, enumeration data use x²Inspection.(note: data process all in the second hospital of Lanzhou University Complete).

2, result

2.1 curative effect determinate standards: with reference to " guideline of clinical investigations of new Chinese medicine treatment CRF " (seeing below literary composition adnexa) system Fixed efficacy assessment standard.

1) effective: 1. clinical symptoms integration reduces >=60%；2. endogenous creatinine clearance rate increases >=20%；3. serum creatinine fall Low >=20%, above 1. item is indispensable, 2., 3. possesses l item, i.e. can determine that.

2) effective: 1. clinical symptoms integration reduces >=30%；2. endogenous creatinine clearance rate >=increase by 10%；3. serum creatinine fall Low >=10%, above 1. item is indispensable, 2., 3. possesses l item, i.e. can determine that.

3) stable: 1. clinical symptoms has been alleviated, integration reduces < 30%；2. endogenous creatinine clearance rate is without reducing, or increases < 10%；3. serum creatinine is without increasing, or reduce by 10%, above 1. item indispensability, 2., 3. possess l item, i.e. can determine that.

4) invalid: 1. clinical symptoms is without improving or increasing the weight of；2. endogenous creatinine clearance rate reduces；3. serum creatinine increases, above 1. item is indispensable, 2., 3. possesses I item, i.e. can determine that.

2.2 efficacy analysis results: refer to table 1 below～3.

Two groups of total effectses of table 1-compare

Note: analyze through Ridit.Two groups of curative effects have significant difference (P < 0.05), and treatment group is better than matched group.

Two groups of curative effects of table 2-and CKD by stages between relation

Note: treatment group 3 phase, 4 phases compare with matched group (same period) significant difference (P < 0.05)；Treatment group 5 phase is with right Compare according to 5 phases of organizing and there was no significant difference (P > 0.05).

Relation between table 3-treatment group pattern of syndrome different from matched group and curative effect

Table 3 result shows: treatment group and matched group are in spleen kidney qi deficiency, yang deficiency of spleen and stomache, the curative effect side of liver-kidney yin deficiency Face compares, and has significant difference (P < 0.05)；Treatment group and matched group are on deficiency of both YIN and YANG type comparitive study, without significance Difference (P > 0.05).

2.3 liang of group leading indicator changes: treatment group is improving renal function, improves glomerular filtration rate aspect and is better than comparison Group.And in terms of erythrocyte, hemoglobin, urine protein, ERY and serum ion, compare without significance before and after two groups of treatments Difference, the results are shown in Table 4.

The comparison (x ± s) of table 4-patient BUN, Set, GFR

3, about the explanation of clinical trial: the clinical research of this Chinese medicine composition fully meets Ethical Principles, fully protects Protect the safety of experimenter.This Chinese medicine composition is intended to clinical value as target, and guiding inventor is at the beginning of research and development, according to medicine Clinical orientation, formulate overall clinical project, specify the purpose of different phase clinical trial, belong in early days exploration and grind Study carefully, constantly carry out risk/benefited assessment, to reduce R&D risk.New in particular for the Chinese medicine under " disease combination " pattern Medicine patent innovation, embodies Chinese medicine composition clinical advantage and feature, embodies the clinical value of Chinese medicine composition, emphasizes effectiveness Should be with the endpoint of disease or generally acknowledged Substitute Indexes evaluation.

For strengthening clinical safety Journal of Sex Research further, it is ensured that CKD patient's heart, liver, the safety of lung important organ damage Evaluate requirement, and coordinate the clinical safety evaluation of the special treatment such as hemodialysis and peritoneal dialysis to pay close attention to main points, it is ensured that The combination of Chinese and Western medicine theory that chronic kidney disease long-term therapy, multiple therapy develop simultaneously.This Chinese medicine composition compound pharmaceutical is for intending in advance Fixed tcm syndrome is verified, and " side's card is corresponding ", belongs to dose-effect relationship research.Generally, Chinese medicine composition of the present invention The controlled trial quantification clear and definite bed test objective of thing and NIAODUQING, defines suitable target patient population, selects the most relatively For the test design method of science, have selected effectiveness according to Chinese medicine composition feature and test objective and safety evaluatio refers to Mark, has the time of rational randomization and baseline estimate, has carried out being layered targetedly to CKD illness.Chinese medicine composition of the present invention The research process that thing is complete all ensure that clinical trial quality control, embody the concrete of and blind random with NIAODUQING KELI Implementation, preferably participates in the conforming method that researcher is evaluated, especially multiple center trial laboratory parameters one The method etc. of cause property.

4, partly this Chinese medicine composition research evidence-based case case and explanation thereof

The present invention treatment to dialysis patient:

Case 1

Name: insult XX, sex: man, the age: 38 years old, national: Han nationality, condition of wedding: married, occupation: individual.

Live: North Road, Jinhua, Shancheng District, Fushan City, Guangdong Province XXX.

Admission time: on December 28th, 2010.

Medical record acquisition time: on July 3rd, 2015.

Patient to be during my institute hemodialysis sky on the 25th, serum creatinine during hemodialysis: 858.81umol/ for the first time L, hemodialysis three times, patient and family members require, with my institute's treatment by Chinese herbs, repeatedly to explain the state of an illness to patient and family members weekly, and they represent Understand, stake out a claim again and again with my institute's treatment by Chinese herbs.I suggestion be to coordinate while conventional hemodialysis and western modern medicine treatment My institute's treatment by Chinese herbs, stops hemodialysis and western modern medicine treatment during the treatment that takes traditional Chinese medicine without authorization, simple treatment by Chinese herbs cause all Accepting the consequences by oneself, if agreeing to above-mentioned requirements, treating after signature.Patient and family members agree, and treat after signature.

Main suit: patient increases 20 in year because of foam of repeatedly urinating, weak, tachypnea 20 days, more than edema first quarter moon.

History of present illness: this is because of flu, cough, weak, tachypnea, Nausea and vomiting, edema, uncomfortable in chest, in Fushan City, Guangdong Province the One the People's Hospital's hospitalization, is diagnosed as chronic glomerulonephritis, chronic kidney disease five phase, renal hypertension, renal anemia, lung Inflammation, extended pattern cardiomyopathy, cardiac function 2 grades, kidney atrophy, done hemodialysis, weekly dialysis three times.Blood flesh before hemodialysis now Acid anhydride: 820.4umol/L, blood urea nitrogen 17.4umol/L, urine protein +++, occult blood ++, hemoglobin 114g/L (reference value 131～ 172), blood pressure 160～120mmHg (depressor takes), glucose in urine+, heart rate 101 beats/min, stringy and rolling pulse number body of the tongue is light red, yellow and thin fur, Be hard and dry 2～3 days the most not smooth, poor appetite, feel sick, do not vomit, the tired pain of the soreness of waist, lower limb aching and limp, about 24h urine volume 1200ml, B Super prompting left kidney size 88mm × 33mm × 37mm, right kidney size 32mm × 34mm × 36mm.

History of past illness: can carry without other important medical histories.

Personal history: being born in Guangdong, the fraud of residence free from dampness, condition still may be used.Eating is pungent, more than ten years of smoking, 10/ Day, low alcohol consumption.

Obsterical history: married.

Allergies: without medicine and food anaphylaxis history.

Family history: both parents are in good health, denies there is familial hereditary history of disease.

Physical examination: T:36.3 DEG C R:21 beat/min P:102 beat/min；Blood pressure: 218/163mmHg.

Skin mucosa and lymph node: skin and mucosa, without xanthochromia, have no macule and scrofula, and superficial lymph knot does not touches swollen Greatly.Head-neck: hair gloss, eye, ear, nose and oral cavity no abnormality seen.Often there is slight edema in eyelid and face.Neck without Tetanic, trachea is placed in the middle, and thyroid is little.Chest: thorax is symmetrical, without deformity；Double pulmonary respiration sounds are clear, do not hear and dry and wet rale； Apex beat does not touches, and heart circle lower-left expands, heart rate 102 beats/min, and rule is neat, does not hears and noise.Abdominal part puts down micro-distension, without tenderness And rebound tenderness, do not touch enclosed mass；Liver spleen not and, murphy sign is negative, and there is percussion pain in Shuan Shen district.Spinal column is without deformity, motion freely； Double lower limb pitting edemas.Anus and external genitalia are not looked into, nervous system: no abnormality seen.

Differential diagnosis in tcm: spleen kidney double void, noxious water turbid damp, obstruction and rejection.

Western medicine diagnose: chronic glomerulonephritis, chronic kidney disease five phase, renal hypertension, renal anemia, extended pattern cardiac muscle Disease, cardiac function 2 grades, kidney atrophy, pneumonia.

Chinese traditional treatment: heat-clearing and toxic substances removing, invigorating the spleen and benefiting QI, purging FU-organs let out turbid, blood circulation promoting and blood stasis dispelling.

About thing: Chinese medicine composition of the present invention (pill), eight balls, three times on the one, early, middle and late taking medicine before meal, avoid pungent, Containing potassium height food.

Western medical treatment: hemodialysis three-times-weekly, takes the whole Western medicine in First People's Hospital of Foshan City on time, digoxin, Nifedipine, benazepril, times his happy g.

Two examine: spirit, diet all increase, and the tired pain of waist, lower limb is aching and limp alleviates, defecate unimpeded once a day, serum creatinine: 556.94umol/L, blood urea nitrogen from 21.62umol/L, urine protein ++, occult blood+.Continue to take Chinese medicine composition of the present invention, once Eight, three times a day.

Three examine: stable disease, and urine protein+, serum creatinine 531.08umol/L, blood urea nitrogen 21.6,5mmol/L.Hemodialysis every two Wednesday time, take Chinese medicine composition of the present invention, one time eight, three times a day.

The four diagnostic methods: all diseases subtract, stable disease, waist is tired, weak, lower limb is aching and limp substantially alleviates, and can adhere to that half a day works, blood flesh Acid anhydride 434.04umol/L, blood urea nitrogen 20.24mmol/L, urine protein+, hemoglobin 133g/L, hemodialysis reduces weekly to once, takes Use Chinese medicine composition of the present invention, one time eight, three times a day.

Five examine: all diseases disappear, and normally, serum creatinine 431.0umol/L, blood urea nitrogen 24.82mmol/L, because of fistula for spirit diet Blockage, does not does hemodialysis treatment in when this comes 25 days.Continue to take Chinese medicine composition of the present invention, one time eight, every day Three times.

Six examine: on July 3rd, 2015.Blood urea nitrogen 14.4mmol/L, creatinine 294.84umol/L, urine protein-, hemoglobin 119g/L.B ultrasonic: left kidney size 87mm × 42mm × 36mm, right kidney size 88mm × 46mm × 36mm, blood flow is normal.Uncomfortable All diseases all disappear, and within the most 3 years four months, do not do hemodialysis treatment, Chinese medicine composition of the present invention so far from Do not stop, near 4 years of normal work.

Note: this patient is feeble and exhausted due to spleen kidney yin sun, disturbance in functioning of QI, turbid damp poison heresy violate stomach and cause with urinary obstruction with vomit Tell and see, for clinical critical disease.There is the situation contrary with four seasons normal pulse in its pulse condition: it is prosperous and powerful that arteries and veins carrys out thick pathogenic factor in the exterior gas, The positive deficiency of vital energy of tiny table declines.Arteries and veins comes should be thick, the most tiny, and pathogenic factor in the exterior gas is prosperous and powerful, and healthy energy is stranded to be hindered in interior；Arteries and veins comes should be thin Little, the thickest, the positive deficiency of vital energy of table declines, and bloom is in outward.The pathological change that this negative and positive are blocked, do not joined mutually, is obstruction and rejection.Obstruction and rejection Disease also, therefore Yun Buzhi.Pathological lesion weight, it is difficult to reverse, and often Progressive symmetric erythrokeratodermia increases the weight of, and treats thorny, poor prognosis.

Case 2

Name: XX slowly, sex: man, the age: 57 years old, national: Han nationality, condition of wedding: married, occupation: peasant.

Live: society of Liang He village two, San Yuan town, Yongjing County.

Admission time: on May 26th, 1997.

Medical record acquisition time: on July 3rd, 2015.

Main suit: more than edema, oliguria, poor appetite first quarter moon, companion's lumbago, gastral cavilty is swollen pain, increase the weight of 2 days.

, there is Dual-eyelid and edema of lower limbs in history of present illness: before 20 days after fatigue, health is tired, nausea and vomiting, weak, do not think Diet, oliguria, once county hospital hospitalization more than 10 day, be diagnosed as glomerulonephritis, renal insufficiency.Unsatisfactory curative effect, Come here go to a doctor.Patients ' vomiting time medical, frequent micturition is short puckery, lumbago, and Dual-eyelid and edema of pair of lower extremities are weak, no Thinking diet, wrist abdominal distention and pain, dry mouth with bitter taste, body of the tongue is light red, thick greasy, the wiry and frequent pulse of pregnant jaundice.

History of past illness: can carry without other important medical histories.

Personal history: can carry without special circumstances.

Obsterical history: married.

Allergies: without medicine and food anaphylaxis history.

Physical examination: T:36.4 DEG C R:18 beat/min P:96 beat/min；Blood pressure: 130/80mmHg.

The four methods of diagnosis: mind is clear, spirit can, looks of generating heat, figure is normal, lamprophonia, abnormal smells from the patient without exception hear and, yellowish complexion lip In vain, making during abdominal distention feels sick retches, and discharge clear water sputum sometimes is defecated not well.Red tongue, tongue is the most greasy, stringy and rolling pulse.

Skin mucosa and lymph node: skin and mucosa, without xanthochromia, have no macule and scrofula, and superficial lymph knot does not touches swollen Greatly.

Head-neck: hair, eye, ear, nose and oral cavity no abnormality seen.Neck is without tetanic, and trachea is placed in the middle, without goiter.Breast Portion: thorax is symmetrical, without deformity；Double pulmonary respiration sounds are clear, do not hear and dry and wet rale；Apex beat and border of cardiac dullness are normal, heart rate 96 beats/min, rule is neat, does not hears and noise.

Abdomen back: abdominal part puts down micro-distension, without tenderness and rebound tenderness, does not touches enclosed mass；Liver spleen not and, murphy sign is negative, There is percussion pain in Shuan Shen district.

Spinal column and extremity: spinal column, without lopsided, tetanic, percussion pain, moves unrestricted；Lower limb pitting edema.Trunk back Visible fish scale sample pathological changes.Anus and external genitalia are not looked into.

Nervous system: no abnormality seen.

Lab testing: laboratory test report is pointed out: blood urea nitrogen 15.7mmol/L, CO₂-CP:20mmol/L, serum creatinine 596.7umol/L, urine protein +++, occult blood +++, the double kidney inflammatory lesion of B ultrasonic prompting.

Western medicine diagnose:

1, glomerulonephritis, renal insufficiency (CKD 4 phase).

2, ichthyosis

Differential diagnosis in tcm: spleen kidney double middle resistance empty, damp and hot, edema, obstruction and rejection.

The rule for the treatment of: heat-clearing and toxic substances removing, damp eliminating, invigorating the spleen and benefiting QI, purging FU-organs let out turbid, blood circulation promoting and blood stasis dispelling.

Side's medicine: Chinese medicine composition of the present invention.One time eight, three times a day, early, middle and late taking medicine before meal, avoid pungent, high containing potassium Food.Double hydrogen g urine thiophene 50 milli g, 2/ day；Radix Sarcococcae Ruscifoliae (Herba Sarcoclccae Ruscifoliae) 50 milli g2 sheet, 2 times/day；Sodium bicarbonate 0.5g, 3 times/day；Yeast tablet 0.3g, 2 Times/day.

Two examine: disease sees Nausea and vomiting, weak, and edema is aggravated, abdominal circumference 83cm, and urine volume 300ml gives furosemide 40mg intramuscular injection, 2/ day, Chinese medicine composition of the present invention, one time eight, three times a day.

Three examine: anasarca substantially alleviates, and feeling sick alleviates, vomit disappearance, abdominal circumference 78cm, laboratory test report prompting: blood urea nitrogen 10.7mmol/L, CO₂-CP:21.4mmol/L, creatinine 147.7umol/L, urinate eight: urine protein+, occult blood-.Continue to take this Bright Chinese medicine composition, one time eight, three times a day.

The four diagnostic methods: edema disappears substantially, urine volume 1500ml/ day, stomach not distension, not nausea and vomiting, spirit diet all increases, and continues Take Chinese medicine composition of the present invention, one time eight, three times a day.

Five examine: patient's readme abdomen gas is unobstructed, weak alleviate, and remaining disease is known and removed.Laboratory test report is pointed out: blood urea nitrogen 4.8mmol/L, CO₂-CP:22mmol/L, creatinine: 107umol/L, urine protein+, occult blood-.For consolidating curative effect, continue to take Chinese medicine composition of the present invention Thing, one time eight, three times a day.

Six examine: patient test's odd number value is normal, and sick announcement is fully recovered, drug withdrawal.

On July 3rd, 2015,18 years are cured.Having become advanced in years old man when following up a case by regular visits to, health is hale and hearty, thinking understands, can also Being engaged in general farm work, seldom have flu, appetite is normal, has a rosy complexion.

Note: before this morbidity, fatigue is weakened body resistance is this, because spleen kidney yang declines, stops in aqueous vapor, dysuria, the heavy pain of extremity Bitterly, the lower profit of stomachache, or limbs edema, tongue is the most thirsty.Treatise on Febrile Diseases is said: " its people still generates heat, under the heart for TAI YANG syndrome diaphoresis, no relieving of symptom after perspiration Throb with fear, dizziness, body move, nearly falling down due to trembling person, Zhen Wu Tang, Decoction for strengthening the Spleen-Yang master it ".The principal agent of Chinese medicine composition of the present invention is Ramulus Cinnamomi, few cloudy interior cold Cut off the water, the medicine of monarch when be Ramulus Cinnamomi simply, walk kidney warming the meridian for it and cold expelling water to insult soil, then the lower profit of stomachache, therefore with Siberian cocklebur, art, Chinese herbaceous peony Medicine, cuts off the water to ooze, only stomachache, and extremity are heavy is wet, and pain is cold, and damp eliminating is dispeled cold complete warm with kidney yang, and kidney yang obtains warm, then water Gas is changed to the greatest extent.And the Gu Wei that activates yang, promoting diuresis to eliminate damp pathogen, medicinal Cortex Cinnamomi, if endogenous dampness contains Ramulus Cinnamomi to be reused, the Rhizoma Atractylodis Macrocephalae.Edema uses the most emphatically Fu Siberian cocklebur, instability of surface person wants light Ramulus Cinnamomi to reuse the Rhizoma Atractylodis Macrocephalae, and Radix Glycyrrhizae is with He Yingwei.

Case history 3

Name: Cai XX；Sex: man；Age: 52 years old；National: Tibetan；Wedding condition: married；Occupation: Hua Long forest farm, Tianzhu work People；Live: Tianzhu, Gansu Province.

Admission time: on February 1st, 2010.

Medical record acquisition time: on July 3rd, 2015.

Main suit: more than Dual-eyelid edema, oliguria April, increases the weight of to accompany lumbago 2 days.

History of present illness: suffer from more than anaphy lactoid purpura nephritis April, renal insufficiency more than 1 month, hepatitis B 20 years Remaining, diabetes half a year, once hospitalization was for several times.In the last few days, fatigue and weak, anorexia, abdominal distention is nauseating, and waist soreness is front Come me to be gone to a doctor.Time medical, patient's disease is seen, lustreless complexion, edema of pair of lower extremities, and purpura is multiple, and abdominal distention is felt sick, and poor appetite is hard and dry 4～5 days are once, light purplish tongue, and corpulent tongue is big, while there is indentation, and thick, yellow and greasy fur, stringy and rolling pulse number, blood pressure 140/90mmHg, body temperature 36.5 DEG C, blood urea nitrogen 11.1mmol/L, creatinine 202.0umol/L, urine protein ++, occult blood +++.

History of past illness: suffer from hepatitis B 20 years, more than diabetes half a year.Just buy GANMAOTONG after having flu by oneself and take history 3～5 years.

Personal history: without special circumstances.

Obsterical history: married.

Allergies: without medicine and food anaphylaxis history.

Physical examination: T:37.4 DEG C R:18 beat/min P:86 beat/min；Blood pressure: 150/90mmHg.

The four methods of diagnosis: mind is clear, spirit can, figure is normal, lamprophonia, abnormal smells from the patient without exception hear and, yellowish complexion lip is white, abdomen Swollen, retch, defecates not well.Light purplish tongue, yellow and greasy fur, deep pulse is counted accurately.Skin mucosa and lymph node: skin and mucosa without xanthochromia, Epidermis is shown in pale red ecchymosis, presses colour-fast, Dual-eyelid edema, double lower limb pitting edemas.Superficial lymph knot does not touches enlargement. Head-neck: hair, eye, ear, nose and oral cavity no abnormality seen, eyelid and facial edema.Neck is without tetanic, and trachea is placed in the middle, first Shape gland is without enlargement.Chest: thorax is symmetrical, without deformity；Double pulmonary respiration sounds are clear, do not hear and dry and wet rale；Apex beat and the heart are turbid Sound circle is normal, heart rate 80 beats/min, and rule is neat, does not hears and noise.Abdomen back: abdominal part puts down micro-distension, does not touches enclosed mass；Liver spleen not and, Murphy sign is negative.Shuan Shen district is without percussion pain.Spinal column and extremity: spinal column extremity are without deformity, and activity is freely.Nervous system: have no Abnormal.Total institute of Lanzhou ground force lab testing: laboratory test report is pointed out: blood urea nitrogen 11.1mmol/L, CO₂-CP 20mmol/L, flesh Acid anhydride 202umol/L, urine protein ++, occult blood +++, B ultrasonic prompting kidney inflammatory lesion.

Western medicine diagnose: anaphylactoid purpura, henoch Schonlein purpura nephritis, renal insufficiency, liver cirrhosis, type 2 diabetes mellitus.

Differential diagnosis in tcm: noxious water turbid damp, damp and hot middle resistance, hematohidrosis, edema.

Chinese traditional treatment: purging FU-organs lets out turbid, blood circulation promoting and blood stasis dispelling, invigorating the spleen and benefiting QI, heat-clearing and toxic substances removing.

Side's medicine: Chinese medicine composition of the present invention.Eight balls, three times a day, early, middle and late taking medicine before meal, avoid pungent, high containing potassium Food.

Two examine: after taking medicine, Nausea and vomiting, weak, and edema alleviates, and purpura is thin out.Total institute of Lanzhou ground force lab testing: Laboratory test report is pointed out: blood urea nitrogen 14.5mmol/L, CO₂-CP:20mmol/L, creatinine 165.6umol/L, urine protein+, occult blood+ +, continue to take Chinese medicine composition of the present invention, eight balls, three times a day.

Three examine: purpura, edema substantially alleviate, and Nausea and vomiting disappears, and laboratory test report is pointed out: blood urea nitrogen 10.7mmol/L, CO₂-CP:21.4mmol/L, creatinine 147.7umol/L, urine protein+, occult blood.No more side effects, continues to take Chinese drug-treated group of the present invention Compound, eight balls, three times a day.

The four diagnostic methods: purpura, edema disappear substantially, urine volume 1500ml/ day, the laboratory test report prompting of the Lan great First Academy: urine protein+, occult blood +, blood urea nitrogen 10.24mmol/L, CO₂-CP:19mmol/L, creatinine 118.9umol/L, patient is joyful.No more side effects, continues Take Chinese medicine composition of the present invention, eight balls, three times a day.

Five examine: patient's readme abdomen gas is unobstructed, weak alleviate, and remaining disease is known and removed.Laboratory test report is pointed out: blood urea nitrogen 4.8mmol/L, CO₂-CP:18mmol/L, creatinine 100umol/L, urine protein+, occult blood.Continue to take Chinese medicine composition of the present invention, eight balls, Three times a day.

Six examine: after taking medicine continuously 1 year, and patient test's odd number value is normal, can eat and can work, and things are as usual, and sick announcement is fully recovered, Drug withdrawal.

Note: because of pyretic toxicity with the passing of time, cave in this patient blood system, under walk kidney meridian, dynamic blood consumption the moon, cause deficiency of kidney-YIN, Deficiency of YIN affecting YANG, folding mistake department, all cards of ecchymosis edema are by giving birth to.The unable promoting the circulation of blood of the deficiency of vital energy, blood must have the stasis of blood, and blood stasis does not goes, and inside stops skin, empty It is mingled with in fact.Chinese medicine composition of the present invention reuses the Radix Astragali, Radix Codonopsis, Fructus Jujubae QI invigorating, and the removing toxic substances of Radix Et Rhizoma Rhei, Periostracum Cicadae develops simultaneously with speckle removing, Rhizoma Smilacis Glabrae Removing toxic substances diuresis, it is intended that treating YANG within YIN, positive cloudy helping and biochemical inexhaustible, therefore obtain effect.

Case history 4

Name a: XX, sex: female, the age: 48 years old, national: Han nationality, condition of wedding: married, occupation: workman, live: ground, Dingxi Oil company of district.

Admission time: on JIUYUE 26th, 1988.

Medical record acquisition time: on July 3rd, 2015,75 years old now.

Patient's identification number: 217062

Main suit: frequent micturition, urgent micturition, dysurea are accompanied weak 2 months.

History of present illness: two months ago because of without obvious cause, frequent micturition, urgent micturition, dysurea.The present increases the weight of and edema, waist because of cold symptoms Bitterly, patient firmly the People's Hospital of Dingxi Prefecture is diagnosed as nephritis, and renal failure is transferred from one hospital to another and is diagnosed as chronic renal in the military region, Lanzhou Zong Yuan Nephropyelitis, chronic renal failure (Uremic).School determines hemodialysis treatment, and patient and family members disagree hemodialysis, is situated between through people The requirement that continues leave hospital after with my institute's treatment by Chinese herbs.Going diagnosis and treatment in home before inviting me after leaving hospital, speak unable during first visit, health is the most empty Weak, it is unable to leave the bed, fatigue and weak, sensation of oppression over the chest with shortness of breath, nausea and vomiting, xerostomia, dry pharynx, it is not intended to drink, lumbago, double lower limb severe edema, It is hard and dry 2～3 days a line, dizzy, dizzy, poor appetite, body of the tongue is light red, and the greasy root of pregnant jaundice is thick, the profound sliding number of arteries and veins, anemia looks, Urine protein ++++, leukocyte ++, pus cell+, erythrocyte ++++, twenty-four-hour urine protein quantification 6g, hemoglobin 6g is (when hospital Blood transfusion is once), creatinine 590.0umol/L, blood urea nitrogen 22.0mmol/L, the double renal function weight of radiosiotope report prompting Spend impaired.

History of past illness: deny having and suffered from the medical histories such as hepatitis, tuberculosis, typhoid fever, hypertension.

Personal history: menstrual history 14 menophania, menstrual period 4～6 days.It is born in ancestral home, goes to school in this locality.

Obsterical history: married.

Allergies: without medicine and food anaphylaxis history.

Physical examination: T:38.4 DEG C R:12 beat/min P:92 beat/min；Blood pressure: 150/90mmHg.

The four methods of diagnosis: mind is clear, spirit can, looks of generating heat, figure is normal, lamprophonia, abnormal smells from the patient without exception hear and, face In vain, feel sick and retch, defecate not well, weak, anorexia, edema, have hematuria.Red tongue, tongue is the most greasy, and deep-slow pulse is unable.Skin Mucosa and lymph node: skin and mucosa, without xanthochromia, have no that macule and scrofula, superficial lymph knot do not touch enlargement.Head-neck: Hair gloss, eye, ear, nose and oral cavity no abnormality seen, after get up in the morning, often there is slight edema in eyelid and face.Neck is without by force Directly, trachea is placed in the middle, without goiter.Chest: thorax is symmetrical, without deformity；Double pulmonary respiration sounds are clear, do not hear and dry and wet rale；The apex of the heart is fought Moving and border of cardiac dullness is normal, heart rate 90 beats/min, rule is neat, does not hears and noise.Abdomen back: abdominal part puts down micro-distension, ureter on abdominal part Point has tenderness, without rebound tenderness, does not touches enclosed mass；Liver spleen not and, murphy sign is negative.There is percussion pain in Shuan Shen district.Spinal column and extremity Without exception, motion freely；Lower limb have pitting edema.Nervous system: no abnormality seen.Lab testing: laboratory test report is pointed out: hematuria Element nitrogen 22mmol/L, CO₂-CP20mmol/L, creatinine 590.0umol/L, 551 μm ol/L.Urinate eight: urine protein ++++, occult blood+ ++, pus cell+, 24 hours protein quantification 6g, routine blood test: the 9 powers/L of 12 numeration of leukocyte 9 × 10 of red rill 8 × 10, B ultrasonic prompting kidney inflammatory lesion.

Western medicine diagnose:

1, chronic pyelonephritis；

2, renal insufficiency (uremia).

Differential diagnosis in tcm: asthenia of both the spleen and kidney, noxious water turbid damp, stagnation of damp-heat three Jiao, obstruction and rejection, edema.

Treatment: heat-clearing and toxic substances removing, damp eliminating, invigorating the spleen and benefiting QI, logical diarrhea is turbid, blood stasis dispelling.

Two examine: after taking medicine, frequent micturition, urgent micturition significantly reduce, deliquescing a line tomorrow of defecating, hydrouria, and edema alleviates, feel sick, Vomiting disappears, and diet increases, uncomfortable in chest, breathing hard is clearly better, urine protein +++, erythrocyte ++, leukocyte one, pus cell one, blood flesh Acid anhydride 320.0umol/L,

Blood urea nitrogen 12.3mmol/L, hemoglobin 7.5g.Continue to take Chinese medicine composition of the present invention, eight balls, every day three Secondary, early, middle and late taking medicine before meal.

Three examine: frequent micturition, urgent micturition, dysurea disappear substantially, stool every day 1～2 times, hydrouria, uncomfortable in chest, breathing hard substantially subtracts Few, diet increases, and speaks strong, sometimes can leave the bed a small amount of movable, urine protein ++, erythrocyte, serum creatinine 180.6umol/L, Blood urea nitrogen 8.64mmol/L, hemoglobin 8.5g.No more side effects, continues to take Chinese medicine composition of the present invention, eight balls, every day Three times, early, middle and late taking medicine before meal.

The four diagnostic methods: edema disappears entirely, the sharp increase of spirit, diet, energy out-of-bed activity, live and can take care of oneself,

Urine protein+, serum creatinine 158.0umol/L, blood urea nitrogen, 8.01mmol/L, hemoglobin 8.6g.Continue to take the present invention Chinese medicine composition, eight balls, three times a day, early, middle and late taking medicine before meal.

Five examine: can suitably outdoor activities, have the symptom of sensation of oppression over the chest with shortness of breath when walking the fastest, urine protein+-, serum creatinine 97.5umol/L, blood urea nitrogen 7.5mmol/L, hemoglobin 9g.Continue to take Chinese medicine composition of the present invention, eight balls, every day three Secondary, early, middle and late taking medicine before meal.

On July 3rd, 2015 follows up a case by regular visits to, and within 27 years, does not recurs, and patient has become healthy old men at 75 years old advanced age, and health is hale and hearty, and thinking is quick Victory, not hard of hearing, eye is not spent, moreover it is possible to be engaged in various housework.

Note: can have systemic infection symptom, urinary tract infection during this morbidity.With prolonged low grade fever for main performance, can accompany Weak, the soreness of waist, inappetence and lose weight, based on hematuria, accompany lumbago, the soreness of waist and urinary tract infection symptom during morbidity.To it Treatment, focus on recovery lung, spleen, the dirty self-regulated ability to water liquid metabolism of kidney three, dampness removing spleen reinforcing, clearing heat and freeing strangury runs through it all the time In, in side, spleen reinforcing is not forgotten in heat clearing away, and diuretic does not forget warming YANG, 1, treat latter 1 year in avoid fatigue in order to avoid increasing the weight of the state of an illness.2, polydipsia is answered Water, daily intake more than 2500 milliliters, increase urine volume, promote that antibacterial, toxin and inflammation secretions are discharged.3, height is actively controlled Blood pressure is highly important link in each phase treatment of nephropathy.4. phychology also plays very important for the treatment of nephritis patient Effect, so good phychology must be kept.In daily life, fatigue to be avoided, there is not too much pressure.And Patient also to keep good living habit, such as reasonably the daily schedule, suitably moves, notes Personal hygiene etc..

Case history 5

Name: non-XX, sex: man, the age: 45 years old, condition of wedding: married, occupation: peasant birthplace: Yongjing, Gansu, national: The Chinese, home address: Wei Chuan village, Xian Yuan town, Yongjing County.

The first visit time: on April 25th, 1997.

Medical history representor: sufferers themselves's degree of reliability: reliable.

Medical record acquisition time: on July 3rd, 2015.

Main suit: after heating, aversion to cold, cough 6 days, anorexia, weak, eyelid and edema of lower limbs more than 4 months, increase the weight of 10 My god.

History of present illness: cause was tired in 4 months, dyspepsia, and flatulence is full, in locality with gastrotherapy, takes Chinese medicine and western medicine, and medicine is not In detail, modern because of cold, fever T38 DEG C, eyelid and edema of lower limbs.It is diagnosed as chronic nephritis, renal insufficiency, uremia at county hospital Phase.Once the therapeutic effect that took traditional Chinese medicine is inconspicuous, therefore comes that I is treated, and time medical, mind understands, grows normal, and question and answer are kept to the point, and dislike The heart, vomiting, tired behaviour does not presses, and yellowish complexion is talked about less, xerostomia, thirsty, is intended to drink, dizzy dizzy, handsome, cardiopulmonary (-), liver spleen not by And, whole body pitting edema, finger submerged while pressing, Shuan Shen district scratches and hits pain (++).

History of past illness: usually health still can, be not suffering from pulmonary tuberculosis and pneumonia, be not suffering from hepatitis, it is without exception that last year looks into liver function； Nineteen ninety-five suffers from dysentery, heals through controlling；Acardia, kidney, blood, endocrine and nervous system disease, also without trauma history.

Personal history: being born in Gansu, the fraud of residence free from dampness, condition still may be used.Eating is pungent, more than ten years of smoking, 10/ Day, low alcohol consumption.

Obsterical history: marrying for 29 years old, spouse has rheumatoid arthritis disease history for many years, has a man and a woman, and health is the most strong.

Allergies: deny allergies.

Family history: mother is over seventy-year-old, Shang Jian.Father is dead in 1980.

Physical examination: T38 DEG C, P92 beat/min, R26 beat/min, blood pressure: 160/98mmHg, urine protein ++++, serum creatinine 698.2umol/L, blood urea nitrogen 23.3mmol/L, hemoglobin 97g.Sanity, nutrition is medium, can grow still, haves a medical check-up qualified, Whole body superficial lymph ties not enlargement, and without subcutaneous nodule, luminous reflectance, without circles such as xanthochromia, isocorias, is existed by sclera, and heart circle is just Often, heart rate 92 beats/min, rule are neat, and each auscultatory valve areas is not heard and pathologic murmur.Pulmonary respiration sound is normal, non-audible and dry and wet sieve Sound, abdominal part has parted edema a little, and without tenderness, liver spleen does not touches, percussion tenderness over kidney region, and neurologic check physiological reflex exists, pathology Reflection is not drawn.

The four methods of diagnosis are examined: expression form: god knows clear, lassitude, and expression misery, complexion is the reddest, the eyes are bright and piercing, and body disappears Thin.Sound abnormal smells from the patient: deep and harsh voice, rough and do not breathe heavily, abnormal smells from the patient without exception hear and.Skin and hair: hypotrichosis, has pale, still Glossy；Skin is moistened, and the colour of skin is without exception, without macule.Picture of the tongue: yellowish fur is the most sliding, red tongue and without petechia, tongue body is big and has Indentation, freely, at the bottom of tongue, venation color is red in activity, has no tortuous.Stringy and rolling pulse number, constipation with dry stool 4～5 days a line.

Western medicine diagnose:

1, chronic nephritis

2, chronic renal insufficiency (uremia)

Differential diagnosis in tcm: spleen kidney is double empty, and stagnation of damp-heat three is burnt, noxious water turbid damp, edema, obstruction and rejection

Treatment: heat-clearing and toxic substances removing, invigorating the spleen and benefiting QI, purging FU-organs is let out turbid, blood stasis dispelling.

Two examine: after taking medicine, anasarca substantially goes down, and defecate unimpeded, hydrouria, and nausea and vomiting disappears, and diet increases, Urine protein ++, occult blood+, serum creatinine 304.9umol/L, blood urea nitrogen 7.1mmol/L, continue to take Chinese medicine composition of the present invention, once Eight balls, three times a day, early, middle and late taking medicine before meal.

Three examine: hydrouria after taking medicine, and edema substantially alleviates, and abdominal part does not rises, and appetite is promoted, blood pressure 140/80mmHg, Urine protein+, serum creatinine 178.0umol/L, no more side effects, continue to take Chinese medicine composition of the present invention, eight balls, three times a day, Early, middle and late taking medicine before meal.

The four diagnostic methods: mental attitude has been recovered to situation during health, since first time medication treatment is not caught a cold again, all are uncomfortable Transference cure, analysis data is normal, takes a period of time Chinese medicine composition of the present invention again for consolidating curative effect.

This patient, through thoroughly fully recovering after 6 months by traditional Chinese medicine composition for treating of the present invention, follows up a case by regular visits on July 3rd, 2015,19 years Do not recur, and various farm work can be engaged in.Flu is seldom had over 19 years.

Note: have before this morbidity flu symptom, followed by occur turbid urine, urine time puckery pain, the soreness of waist, weak, gas Short, dizzy, edema feeling of fullness, time sense symptoms such as tending to vomit of feeling sick treated by the dialectical of the traditional Chinese medical science, this card is edema, card belongs to spleen deficiency of kidney-QI Type and three burnt damp-heat type traditional Chinese medicine composition for treating of the present invention, Ramulus Cinnamomi in side, Periostracum Cicadae induce sweat damp eliminating；Fructus Crataegi (parched), Massa Medicata Fermentata, Rhizoma Smilacis Glabrae Invigorating spleen for diuresis；Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Radix et Rhizoma Rhei (stir-fried with wine), Serissa foetida spleen invigorating clearing heat and expelling damp are main；Because of the traditional Chinese medical science think deficiency of kidney yin, see soreness of waist waist The deficiency of YIN bitterly is given birth to interior-heat, is seen low grade fever, dysphoria with feverish sensation in the chest palms and soles, xerostomia dry pharynx；Damp-heat in the urinary bladder, key road is unfavorable, see frequent micturition, dark coloured urine yellow skin.Treatment Middle spleen invigorating is that crucial, the traditional Chinese medical science is suffered from a deficiency of the kidney damp and hot " General Treatise on the Cause and Symptoms of Diseases " cloud: " Zhu Linzhe, all suffer from a deficiency of the kidney and bladder heat also." this pathogenesis Feature is particularly well suited to patients with chronic glomerulonephritis or uremic patient.

Claims

1. treat chronic renal failure and cause the Chinese medicine composition of disease for one kind, it is characterised in that: by the medical material of following weight portion It is processed into: Fructus Crataegi (parched) 4～8 parts, stir-fry Pericarpium Citri Reticulatae 4～8 parts, Radix Angelicae Sinensis 4～8 parts, Radix Paeoniae Alba (parched) 4～8 parts, stir-baked Fructus Aurantii in bran 3～7 parts, green grass or young crops Skin 3～7 parts, Radix Paeoniae Rubra 4～8 parts, Flos Carthami 1～5 parts, Periostracum Cicadae 1～5 parts, Radix Astragali 25～35 parts, old vinegar fry Rhizoma Curcumae 4～8 parts, Rhizoma Chuanxiong 4～8 parts, fry king do not stay 1～5 part, old vinegar fry Rhizoma Sparganii 1～5 parts, processed with honey Fructus Schisandrae Chinensis 7～12 parts, Serissa foetida 4～8 parts, Radix Ginseng 3～7 parts, wine army 4～8 parts, Radix Glycyrrhizae Preparata 3～7 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 4～8 parts, Rhizoma Smilacis Glabrae 4～8 parts, Ramulus Cinnamomi 4～8 parts, water Trematodiasis 4～8 parts, Eupolyphaga seu steleophaga 1～5 parts, Pheretima 1～5 parts.

A kind of Chinese medicine composition treated chronic renal failure and cause disease, it is characterised in that: by The processing of crude drugs of following weight portion is made: Fructus Crataegi (parched) 5～7 parts, stir-fry Pericarpium Citri Reticulatae 5～7 parts, Radix Angelicae Sinensis 5～7 parts, Radix Paeoniae Alba (parched) 5～7 parts, bran Fructus Aurantii (parched) 4～6 parts, Pericarpium Citri Reticulatae Viride 4～6 parts, Radix Paeoniae Rubra 5～7 parts, Flos Carthami 2～4 parts, Periostracum Cicadae 2～4 parts, Radix Astragali 28～32 parts, Lao Chen Rhizoma Curcumae Phaeocaulis (parched with vineger) 5～7 parts, Rhizoma Chuanxiong 5～7 parts, fry king do not stay 2～4 parts, old vinegar fry Rhizoma Sparganii 2～4 parts, processed with honey Fructus Schisandrae Chinensis 8～10 Part, Serissa foetida 5～7 parts, Radix Ginseng 4～6 parts, wine army 5～7 parts, Radix Glycyrrhizae Preparata 4～6 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 5～7 parts, Rhizoma Smilacis Glabrae 5～7 Part, Ramulus Cinnamomi 5～7 parts, Hirudo 5～7 parts, Eupolyphaga seu steleophaga 2～4 parts, Pheretima 2～4 parts.

A kind of Chinese medicine composition treated chronic renal failure and cause disease, it is characterised in that: by The processing of crude drugs of following weight portion is made: Fructus Crataegi (parched) 6 parts, stir-fry Pericarpium Citri Reticulatae 6 parts, Radix Angelicae Sinensis 6 parts, Radix Paeoniae Alba (parched) 6 parts, stir-baked Fructus Aurantii in bran 5 parts, green grass or young crops Skin 5 parts, Radix Paeoniae Rubra 6 parts, 3 parts of Flos Carthami, Periostracum Cicadae 3 parts, Radix Astragali 30 parts, old vinegar fry Rhizoma Curcumae 6 parts, Rhizoma Chuanxiong 6 parts, fry king do not stay 3 parts, Old vinegar fries Rhizoma Sparganii 3 parts, processed with honey Fructus Schisandrae Chinensis 9 parts, Serissa foetida 6 parts, Radix Ginseng 5 parts, wine army 6 parts, Radix Glycyrrhizae Preparata 5 parts, Rhizoma Atractylodis Macrocephalae (parched with earth) 6 Part, Rhizoma Smilacis Glabrae 6 parts, Ramulus Cinnamomi 6 parts, Hirudo 6 parts, Eupolyphaga seu steleophaga 3 parts, Pheretima 3 parts.