CN101537076A - Chinese traditional medicine composition for curing angitis and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese traditional medicine composition for curing angitis, which comprises figwort root, red peony root, cassia twig, safflower, bitter orange, Chinese angelica, dried rehmannia root, chuanxiong rhizome, Chinese cinnamon, astragalus root, spatholobus stem, white peony root, red sange root, achyranthes root and/or a pharmaceutically accepted carrier. The invention also relates to a preparation method of the Chinese traditional medicine composition. The Chinese traditional medicine composition has the effects of clearing away heat and toxic material, promoting blood circulation and stopping pain and warming yang to expel cold and is used for various symptoms such as endless limb pain, rot and diabrosis, mental exhaustion, pale complexion, and the like caused by the angitis.

Description

Vasculitic Chinese medicine composition of a kind of treatment and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition, specifically, relate to vasculitic Chinese medicine composition of a kind of treatment and preparation method thereof.

Background technology

The vasculitis full name is a thromboangiitis obliterans, is because the medium and small arterial thrombus obturation of lower limb causes a kind of serious disease of vascular inflammation.Normal blood vessel divides internal layer, middle level and skin.Internal layer is very smooth, and blood is trickling in the inside; The middle level is a Musclar layer, is to keep elasticity of blood vessels; Outer separately is a very slick structure with its hetero-organization.Participate in pathological changes and suffer from vasculitic blood vessel wall by lining and outer holostrome, the struvite change of internal layer causes lumen of vessels narrow; The middle level changes makes muscle ossify poor flexibility; Circumvascular nerve, adventitia, muscle also participate in struvite change simultaneously, produce a series of symptoms.Suffering from vasculitic high-risk group is smoker's (especially male adults), psychentonia person, unbalanced, the cold humid area resident of nutrition, Inheritance factor.

Vasculitic early symptom has: 1, fiber crops, cool, bitterly; 2, easily tired, shank is sour expands; 3, pulse weakened, fade away.

Mid-term, symptom was: 1, in the activity shank occur pain, 2, muscle twitches, especially night obvious; 3, intermittent claudication.

Late period, symptom had: 1, continue to have an intense pain; Ulcer takes place in 2, dark red, the pitchy of skin; 3, foot, toe blackening, necrosis.

The vasculitic cause of disease is not still understood.Statistics shows that cold district vasculitis sickness rate is higher than warm area, and the smoking population sickness rate is higher than the non-smoker, so Most scholars is thought primary disease morbidity and long-term smoking and be subjected to cold relevant.It is relevant with the immune genetic factor etc. that the somebody thinks.The primary disease youth between 20～40 years old of mostly occurring, and the ill ratio of men and women is 29: 1.Before mainly involving the shin of calf, behind the shin, several groups of tremulous pulsies in instep, can upwards involve femoral artery when serious, even limb vessel is got involved all.Because thrombosis, obliteration, blood can cause multiple infringements such as thrombophlebitis, arteritis, intermittent claudication, histotrophic nutrition obstacle even necrosis for not enough, can the serious harm body health.

The traditional Chinese medical science thinks that vasculitis belongs to " necrosis " category.In Huangdi's Internal Classics, just put down in writing relevant for primary disease." section's case outside the Ma Pei " said: " temperature compensation of ancient book meaning borax, greasy and surfeit flavour too ... then give birth to necrosis ... the swollen heat in the back of foot, toes are still cold, and skin and flesh muscles and bones is all dead, and the joint seam gradually splits for a long time, sewage seepage flow, tendon breaking meat from and take off.Look the power of its natural endowment, all amass due to the heat, relieve inflammation or internal heat based on yin nourishing.”

The traditional Chinese medical science is divided into four types of asthenic cold type, damp-heat type, stasis type and heat-toxin types with vasculitis:

(1) asthenic cold type first meeting lower limb send out cold, be afraid of cold, numb, pain, simultaneously with tired sense, local swelling constriction or vola underbed sense have intermittent claudication, are stranded, suppress bloated during walking because of shank is heavy, distance is shorter and shorter.

(2) damp-heat type shows as and suffers from that limb is afraid of cold, pain, often is migration.During walking lower limb aching and tired, suppress bloated, heavy weak; Lump or tuberosity, red and swollen heat pain often appear in lower limb; Suffer from limb edema sometimes.

(3) the stasis type shows as and suffers from limb and be afraid of cold, and that touches is ice-cold, and pain is persistence, purplish red, the dark red or livid purple color of skin, and foot skin has petechiae.

(4) heat-toxin type shows as and suffers from limb pain, and light night on daytime is heavy, and limbs are local red and swollen, big dry stool.

Thromboangiitis mainly shows as patient's finger or purple, numbness, cold type of pain symptom appear in toe, and the later stage can occur festering and downright bad phenomenon, and severe patient can cause trick Can Fei.Mainly due to patient's insufficiency of primordial QI, QI and blood can not reach in the blood vessel tip, makes finger or toe can not get nutrition and necrosis gradually.Doctor trained in Western medicine thinks that sanguimotor strength is the pressure that produces by heart collecting moving, not exclusively is so in fact, and when stopping to beat suddenly when the human heart necrosis, human body still has certain portal vein blood pressure, the strength of the vigour that Here it is does not decline.

The traditional Chinese medical science adopts heat-clearing and toxic substances removing, this disease of the decoction for the treatment of promoting blood circulation and stopping pain, warming YANG to expel cold.

Summary of the invention

The purpose of this invention is to provide the vasculitic Chinese medicine composition of a kind of treatment.

The present invention also aims to provide a kind of preparation method of this Chinese medicine composition.

In order to realize purpose of the present invention, the invention provides the vasculitic Chinese medicine composition of a kind of treatment, be to make by effective ingredient and/or pharmaceutically acceptable carrier, described effective ingredient is made by weight by following raw materials according:

Radix Scrophulariae 10-20 part Radix Paeoniae Rubra 5-15 part Ramulus Cinnamomi 5-10 part

Flos Carthami 10-15 part Fructus Aurantii 15-25 part Radix Angelicae Sinensis 15-20 part

Radix Rehmanniae 20-30 part Rhizoma Chuanxiong 5-10 part Cortex Cinnamomi 10-20 part

Radix Astragali 15-20 part Caulis Spatholobi 15-25 part Radix Paeoniae Alba 10-15 part

Radix Salviae Miltiorrhizae 5-15 part Radix Cyathulae 10-15 part

Effective ingredient is preferably made by weight by following raw materials according:

8 parts of 11 parts of Ramulus Cinnamomi of 16 parts of Radix Paeoniae Rubra of Radix Scrophulariae

18 parts of 21 parts of Radix Angelicae Sinensis of 12 parts of Fructus Aurantiis of Flos Carthami

16 parts of 8 portions of Cortex Cinnamomis of 26 parts of Rhizoma Chuanxiongs of the Radix Rehmanniae

13 parts of 21 portions of Radix Paeoniae Albas of 18 portions of Caulis Spatholobis of the Radix Astragali

13 parts of 12 portions of Radix Cyathulaes of Radix Salviae Miltiorrhizae

The present invention also provides a kind of preparation method of this Chinese medicine composition, comprises the steps:

(1) Fructus Aurantii to be ground into impalpable powder standby;

(2) Radix Angelicae Sinensis, the Radix Rehmanniae, Radix Salviae Miltiorrhizae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Scrophulariae, Radix Paeoniae Rubra, Ramulus Cinnamomi, Flos Carthami, Rhizoma Chuanxiong, Cortex Cinnamomi, the Radix Astragali, Caulis Spatholobi, the Radix Paeoniae Alba, Radix Cyathulae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.

Pharmaceutical composition of the present invention can with receivable carrier pharmaceutically, for example: filler such as starch, microcrystalline Cellulose etc.; Binding agent such as vitamin derivative, starch etc.; Mode by granule, capsule, tablet oral administration is used.

Chinese medicine composition of the present invention has heat-clearing and toxic substances removing, the effect of promoting blood circulation and stopping pain, warming YANG to expel cold, be used for the thrombosis vascular and be the trouble limb pain that causes endlessly, rot diabrosis, neurolysis, diseases such as pale complexion.。

The specific embodiment:

Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.

Embodiment: 1 Chinese medicinal composition granules of the present invention

(1) to be ground into impalpable powder standby for Fructus Aurantii 210g;

(2) Radix Angelicae Sinensis 180g, Radix Rehmanniae 260g, Radix Salviae Miltiorrhizae 120g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Scrophulariae 160g, Radix Paeoniae Rubra 110g, Ramulus Cinnamomi 80g, Flos Carthami 120g, Rhizoma Chuanxiong 80g, Cortex Cinnamomi 160g, Radix Astragali 180g, Caulis Spatholobi 210g, Radix Paeoniae Alba 130g, Radix Cyathulae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 1000g, lactose 800g, mixing, with 75% ethanol wet granulation promptly.

Embodiment 2: Chinese medicinal composition capsules agent of the present invention

(1) to be ground into impalpable powder standby for Fructus Aurantii 210g;

(2) Radix Angelicae Sinensis 180g, Radix Rehmanniae 260g, Radix Salviae Miltiorrhizae 120g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Scrophulariae 160g, Radix Paeoniae Rubra 110g, Ramulus Cinnamomi 80g, Flos Carthami 120g, Rhizoma Chuanxiong 80g, Cortex Cinnamomi 160g, Radix Astragali 180g, Caulis Spatholobi 210g, Radix Paeoniae Alba 130g, Radix Cyathulae 130g decoct with water secondary, each 2 hours, filter, merging filtrate, left standstill 48 hours, and got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, add above-mentioned fine powder and clear paste, drying is ground into fine powder, adds dextrin 700g, mixing, in the capsulae vacuus of packing into promptly.

Embodiment 3: Chinese medicine composition tablet of the present invention

(1) to be ground into impalpable powder standby for Fructus Aurantii 210g;

(2) Radix Angelicae Sinensis 180g, Radix Rehmanniae 260g, Radix Salviae Miltiorrhizae 120g are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Scrophulariae 160g, Radix Paeoniae Rubra 110g, Ramulus Cinnamomi 80g, Flos Carthami 120g, Rhizoma Chuanxiong 80g, Cortex Cinnamomi 160g, Radix Astragali 180g, Caulis Spatholobi 210g, Radix Paeoniae Alba 130g, Radix Cyathulae 130g decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, got supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, add starch 300g, microcrystalline Cellulose 200g is with 70% ethanol wet granulation, tabletting, coating are promptly.

Claims (4)

1, the vasculitic Chinese medicine composition of a kind of treatment is to be made by effective ingredient and/or pharmaceutically acceptable carrier, it is characterized in that described effective ingredient is made by weight by following raw materials according:

Radix Scrophulariae 10-20 part Radix Paeoniae Rubra 5-15 part Ramulus Cinnamomi 5-10 part

Flos Carthami 10-15 part Fructus Aurantii 15-25 part Radix Angelicae Sinensis 15-20 part

Radix Rehmanniae 20-30 part Rhizoma Chuanxiong 5-10 part Cortex Cinnamomi 10-20 part

Radix Astragali 15-20 part Caulis Spatholobi 15-25 part Radix Paeoniae Alba 10-15 part

Radix Salviae Miltiorrhizae 5-15 part Radix Cyathulae 10-15 part.

2, Chinese medicine composition as claimed in claim 1 is characterized in that described effective ingredient made by weight by following raw materials according:

8 parts of 11 parts of Ramulus Cinnamomi of 16 parts of Radix Paeoniae Rubra of Radix Scrophulariae

18 parts of 21 parts of Radix Angelicae Sinensis of 12 parts of Fructus Aurantiis of Flos Carthami

16 parts of 8 portions of Cortex Cinnamomis of 26 parts of Rhizoma Chuanxiongs of the Radix Rehmanniae

13 parts of 21 portions of Radix Paeoniae Albas of 18 portions of Caulis Spatholobis of the Radix Astragali

13 parts of 12 portions of Radix Cyathulaes of Radix Salviae Miltiorrhizae.

3,, it is characterized in that described Chinese medicine composition can be made into granule, capsule and tablet as the arbitrary described Chinese medicine composition of claim 1-2.

4, a kind of preparation method as the arbitrary described Chinese medicine composition of claim 1-3 comprises the steps:

(1) Fructus Aurantii to be ground into impalpable powder standby;

(2) Radix Angelicae Sinensis, the Radix Rehmanniae, Radix Salviae Miltiorrhizae are with 60% alcohol reflux secondary, and each one hour, gradation filtered, and it is the clear paste of 1.15 (60 ℃) that merging filtrate, concentrating under reduced pressure become relative density;

(3) Radix Scrophulariae, Radix Paeoniae Rubra, Ramulus Cinnamomi, Flos Carthami, Rhizoma Chuanxiong, Cortex Cinnamomi, the Radix Astragali, Caulis Spatholobi, the Radix Paeoniae Alba, Radix Cyathulae decoct with water secondary, each 2 hours, filter, merging filtrate left standstill 48 hours, get supernatant, it is the thick paste of 1.20 (60 ℃) that concentrating under reduced pressure becomes relative density, adds above-mentioned fine powder and clear paste, drying, be ground into fine powder, make granule, capsule and tablet with pharmaceutically acceptable carrier.