CN100464775C - Chinese medicinal oral liquid for treating hypertension - Google Patents
Chinese medicinal oral liquid for treating hypertension Download PDFInfo
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- CN100464775C CN100464775C CNB2006101650074A CN200610165007A CN100464775C CN 100464775 C CN100464775 C CN 100464775C CN B2006101650074 A CNB2006101650074 A CN B2006101650074A CN 200610165007 A CN200610165007 A CN 200610165007A CN 100464775 C CN100464775 C CN 100464775C
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Abstract
The invention relates to a Chinese medicinal oral liquid for treating hypertension, which is prepared from raw materials of peach kernels, root of ballon flower, abalone shell, safflower, Bupleurum root, cape jasmine, Chinese angelica root, bitter orange, poria with hostwood, dried rehmannia root, licorice root, baikal skullcap root, Ligusticum wallichii, gastrodia tuber, eucommia bark, radix paeoniae rubrathe, hooked uncaria, motherwort, achyranthes and cyathula root, cassia seed, Loranthus mulberry mistletoe, and tuber fleeceflower stem.
Description
Technical field
The present invention relates to the hypertensive medicament of a kind of treatment, is that the various hypertension of a kind of main treatment are the Chinese patent medicine of raw material with the Chinese herbal medicine.
Background technology
Hypertension is a kind of commonly encountered diseases, and clinical manifestation is easy on the trigger, and is busy nervous at body, sometimes but feel bored stiff, all are not taken things philosophically, feel that life do not have enjoyment, in the daytime sleepy, the insomnia at night, neurasthenia's phenomenon is arranged, dizzy headache, dizzy state is slight, as ascend a height to overlook and have slight dizzy sensation, the phenomenon that tinnitus is often arranged, sense pain in the time of on the crown or the eyelid, bipod shakiness when walking, as as speeding across the sky, top-heavy, head feels that weight is arranged, the action rapid breathing, abdominal part has the sense of expansion, press just like pillow in the chest, and face is little red, and trick is ice-cold.Doctor trained in Western medicine does not think that hypertension is a kind of disease, thinks that hypertension is to be raise by the caused blood pressure change of diseases such as nephritis, renal atrophy, sclerosis of blood vessels, aorta defective, erythrocytosis, hyperthyroidism, adrenal gland's struma, hypophysis tumor.The traditional Chinese medical science think hypertension be belong to blood stasis disease, blood stasis hinder in the heart or on combine in head, blood stasis is stagnated and is loose, and is deficiency of the liver and kindey, liver-yang is high partially, due to the burning hot liver-wind pathogen upward attacking orifices in head.Current, treatment hypertension Western medicine commonly used, these Western medicine not only cost an arm and a leg, and toxic and side effects is also higher, and it is the work of always studying that hypertension is treated in utilization Chinese herbal treatment or auxiliary smelting, but present medicine can not effect a radical cure, and curative effect can not be satisfactory.
Summary of the invention
The purpose of this invention is to provide the hypertensive Chinese medicine oral liquid of a kind of treatment, can treat and effect a radical cure hypertension, and the relevant disease that other hypertension causes is also had better curative effect.
Solution of the present invention is according to the rule of the traditional Chinese medical science to hypertension therapeutic, i.e. the body resistance strengthening and constitution consolidating, and the kidney invigorating collateral dredging, blood circulation promoting and blood stasis dispelling, the detoxifcation pain relieving, hard masses softening and resolving and dampness removing fluid-purging therapy, the present invention forms according to above-mentioned rule, and pharmacological action is as follows:
1, controls and belong to blood stasis hypertension, blood stasis and hinder in the heart or go up and in head, then chest pain, headache, blood stasis are stagnated and loose, so aching as needle stabbing and the place of deciding is arranged.Heart blood placed in the middle and main, blood stasis are become homeless foster in breast, the heart, so palpitation and insomnia.Blood stasis, with the passing of time heat-transformation, interior-heat unhappiness then, suddenly make an uproar irritability, hectic fever at dusk.Blood stasis hinders in gastral cavilty, and failure of stomach-QI to descend is so blood stasis, blood are sticking, blood is thick, hypertension, do not fall.Dark tongue quality has ecchymosis, and petechia and lip order are black dull, and arteries and veins or puckery or string (disease of microcirculation disturbance) are all resembling of blood stasis, controls to dispel in the heart that blood stasis is main, drinks the medicine of the smooth chest and diaphragm mechanism of qi of auxiliary tone.The present invention is monarch with blood circulation promoting and blood stasis dispelling such as Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Paeoniae Rubras.Chinese Angelica blood replonishing is invigorated blood circulation, promoting tissue regeneration by removing blood stasis, and Radix Rehmanniae blood enriching and dryness moistening is a minister with Radix Angelicae Sinensis 5 nourshing blood and promoting blood circulation mutually, by arthralgia due to stagnation of blood, this six medicine promptly is the main formula of blood circulation promoting and blood stasis dispelling.Radix Platycodonis, Radix Bupleuri priming is up to be beneficial to the soothing the liver assistant that is, the circulation of qi promoting of Fructus Aurantii the chest stuffiness relieving makes blood circulation depending on qi flow, Radix Cyathulae, and promoting blood circulation, it is descending to draw blood stasis, is messenger drug, and Radix Glycyrrhizae lead to hundred arteries and veins, coordinating the actions of various ingredients in a prescription (helping tissue, organ blood flow perfusion, the recovery of promotion circulatory disturbance).
2, controlling intractable hypertension, headache, dizzy, insomnia, is deficiency of the liver and kindey, and liver-yang is high partially, intimately due to the liver-wind pathogen upward attacking orifices in head.Control and to put out the master by suppressing the hyperactive liver, be equipped with clearing away heat-fire, the method for liver and kidney tonifying.Rhizoma Gastrodiae is main in the side, goes into Liver Channel, suppressing the hyperactive liver to relieve the wind syndrome, Ramulus Uncariae Cum Uncis clearing away liver-fire, suppressing the hyperactive liver sun, two medicines mutually 5, suppressing the hyperactive liver to relieve the wind syndrome, shared is monarch, minister with Concha Haliotidis, Semen Cassiae Pingyang YANG hyperactivity suppressing, make eye bright, with blood pressure, with blood fat, loosening bowel to relieve constipation.Assistant is rushed down the three warmers pathogenic fire clearly with Fructus Gardeniae, and the kind clear part of the body cavity above the diaphragm housing the heart and lungs of Radix Scutellariae and Rhizoma Chuanxiong is burning hot, the Cortex Eucommiae, Herba Taxilli liver and kidney tonifying, Herba Leonuri activating blood and promoting diuresis.Help the Radix Cyathulae conducting blood to flow downwards, Caulis Polygoni Multiflori, Poria cum Radix Pini, tranquilizing the mind are for making, and all medicines are harmonious, and play suppressing liver-wind altogether, heat clearing and blood circulation promoting, and liver and kidney tonifying, Ramulus Uncariae Cum Uncis and Semen Cassiae are gone into Liver Channel, are relieved inflammation or internal heat, blood pressure lowering.The Cortex Eucommiae, Herba Taxilli and Semen Cassiae liver and kidney tonifying, make eye bright the solid cubic content in Radix Cyathulae and the Semen Cassiae blood.Fructus Gardeniae, Radix Scutellariae, Rhizoma Chuanxiong, Semen Cassiae and Concha Haliotidis publicly price-reduction brain blood pressure, intraocular pressure, the early stage edema of treatment brain.
3, the combined back of two sides: can effectively increase tremulous pulse, venous blood flow, reduce the degree of injury of myocardial ischemia and infraction, reduce vascular resistance, suppress the formation of coronary atherosclerosis, improve the cerebral tissue microcirculation, adjust circulatory disturbance, and can blood sugar lowering, blood fat, sticking, the hypertension of blood.The main blood vessel dilating of we, anti-platelet aggregation, antithrombotic forms, and there is inhibitory action in system to platelet adhesion, ischemic heart and brain blood coronary heart disease, angina pectoris etc. are had significant curative effect, cause upper limb paralysis, lower extremity paralysis functional rehabilitation that better curative effect is all arranged obliterated cerebral vascular disease, hypertension.
The present invention comprises that the following weight proportion raw material makes:
25~30 parts of 5~8 parts of Concha Haliotidis of 12~20 parts of Radix Platycodoniss of Semen Persicae
9~15 parts of 3~5 portions of Fructus Gardeniaes of 9~15 parts of Radix Bupleuri of Flos Carthami
9~15 parts of 6~10 parts of Poria cum Radix Pinis of 9~16 parts of Fructus Aurantiis of Radix Angelicae Sinensis
9~15 parts of 3~5 parts of Radix Scutellariaes of 9~15 portions of Radix Glycyrrhizaes of Radix Rehmanniae
9~15 parts of 9~15 parts of Cortexs Eucommiae of 5~8 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
9~15 parts of 20~30 parts of Herba Leonuris of 6~9 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
9~15 parts of 25~30 parts of Herba Taxillis of 6~15 parts of Semen Cassiaes of Radix Cyathulae
9~15 parts of Caulis Polygoni Multiflori.
Formula optimization of the present invention comprises that the weight proportion of each raw material is:
21~25 parts of 6~7 parts of Concha Haliotidis of 14~18 parts of Radix Platycodoniss of Semen Persicae
10~14 parts of 3~4 portions of Fructus Gardeniaes of 10~14 parts of Radix Bupleuri of Flos Carthami
10~14 parts of 7~9 parts of Poria cum Radix Pinis of 10~14 parts of Fructus Aurantiis of Radix Angelicae Sinensis
10~14 parts of 3~4 parts of Radix Scutellariaes of 10~14 portions of Radix Glycyrrhizaes of Radix Rehmanniae
10~14 parts of 10~14 parts of Cortexs Eucommiae of 6~7 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
10~14 parts of 23~27 parts of Herba Leonuris of 7~8 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
10~14 parts of 26~27 parts of Herba Taxillis of 7~14 parts of Semen Cassiaes of Radix Cyathulae
10~14 parts of Caulis Polygoni Multiflori.
Prescription of the present invention is best to comprise that the weight proportion of each raw material is:
22.5 parts of 6.5 parts of Concha Haliotidis of 16 parts of Radix Platycodoniss of Semen Persicae
12 parts of 4 portions of Fructus Gardeniaes of 12 parts of Radix Bupleuri of Flos Carthami
12 parts of 8 parts of Poria cum Radix Pinis of 12 parts of Fructus Aurantiis of Radix Angelicae Sinensis
12 parts of 4 parts of Radix Scutellariaes of 12 portions of Radix Glycyrrhizaes of Radix Rehmanniae
12 parts of 12 parts of Cortexs Eucommiae of 6 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
12 parts of 25 parts of Herba Leonuris of 8 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
12 parts of 22.5 parts of Herba Taxillis of 12 parts of Semen Cassiaes of Radix Cyathulae
12 parts of Caulis Polygoni Multiflori.
The present invention can be made into oral liquid, and the Cortex Eucommiae is selected the burnt Cortex Eucommiae, and method for making is not stated tired as " newly organized Chinese medicine processing method " event.Get above-mentioned 22 flavor Chinese medicines earlier and pulverize, cross 80 mesh sieves, make medicated powder, medicated powder is inserted in the container, add the distilled water that 109-150 restrains, be heated to temperature 80-90 ℃ by per 100 gram medicated powder, insulation 10-15 hour is made the medicine slurry, with 520 type hydraulic pressure pressure filter, squeeze and filter goes out medicine juice, add the Mel that accounts for medicine juice gross weight 0.5% again, stir, with the automatic medicine boiling packaging machine of KY8-200Az type, it is packed that sterile package is dressed up 50ml-200ml, and also available PVC/YE composite film packaging becomes 10mlx10 to prop up/box.Oral, a 50ml, three times on the one, 15 days one courses of treatment.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, the Chinese herbal medicine each component selected for use of the present invention meets the pharmaceutical control law regulation, utilizes the comprehensive function treatment hypertension of the Chinese medicine of respectively distinguishing the flavor of, and does not have chemical sweeting agent, and is nontoxic to human body.Show that through animal acute toxicity test underproof animal end sees any toxic reaction, its main organs does not have tangible change yet, and mice is 40g crude drug/kg to the maximum tolerated dose of medicine of the present invention, is 150 times of clinical people's consumption, and safety of medicine is reliable.
2, the present invention need not decoct, no bitterness sense, rich in proteins, volatile oil, starch, glucose, phlegmatic temperament, organic acid, fatty oil, Radix Angelicae Dahuricae element, vitamin and nearly tens seed amino acids in the medicine, also contain various trace elements such as potassium, zinc, calcium, ferrum, be beneficial to absorption of human body, health invigorating, and taking convenience.
3, the present invention can treat and effect a radical cure hypertension effectively, and the relevant disease that other hypertension causes is also had the effect of better curative effect function, has improved patient's life quality and the time greatly, and higher healing rehabilitation efficacy is arranged.
For showing medicine of the present invention to hypertensive therapeutic effect, through clinical test results as:
Hypertensive diagnostic criteria: under the situation of not taking medicine, measuring condition meets the blood pressure diagnostic criteria, and adult (over 18 years old) systolic pressure 〉=140mmHg or diastolic pressure 〉=90mmHg are hypertension.
Being classified as follows of blood pressure level:
Ideal bp: systolic pressure<120, diastolic pressure<80;
Normal arterial pressure: systolic pressure<130, diastolic pressure<85;
Normal high value: systolic pressure 130-139, diastolic pressure 85-89;
1 grade of hypertension: systolic pressure 140-159, diastolic pressure 90-99;
2 grades of hypertension: systolic pressure 160-179, diastolic pressure 100-109;
3 grades of hypertension: systolic pressure 〉=180, diastolic pressure 〉=110;
Isolated systolic hypertension: systolic pressure 〉=140, diastolic pressure<90
Subgroup: critical systolic hypertension: systolic pressure 140-149, diastolic pressure<90.
The dangerous definition of hypertension layering:
1, high danger group: 3 grades of hypertension or hypertension 1-2 level companion's target organ damage (as diabetes, the heart, brain, kidney, angiopathy) and relevant clinical disease.
2, high-risk group: hypertension 1-2 level, accompany at least 3 target organ damages, risk factor.
3, middle danger group: 1 grade of hypertension, accompany 1-2 target organ damage, risk factor, or 2 grades of hypertension are without being no more than 2 target organ damages, risk factor.
4, low danger group: 1 grade of hypertension is not mixed with above-mentioned risk factor.
To the hyperpietic (men and women half and half) of above-mentioned standard, it is as follows to take oral liquid treatment effect of the present invention:
Oral, a 50ml, three times on the one, 15 days one courses of treatment are through 1-2 the course of treatment.The component curative effect:
Normal high value: 542 people reach normal arterial pressure 17 people, reach ideal bp 525 people;
1 grade of hypertension: 873 people reach normal high value 15 people, reach normal arterial pressure 157 people, reach ideal bp 699 people;
2 grades of hypertension: 298 people reach 1 grade of hypertension 7 people, reach normal high value 34 people, reach normal arterial pressure 78 people, reach ideal bp 178 people;
3 grades of hypertension: 193 people reach 2 grades of hypertension 5 people, reach 1 grade of hypertension 17 people, reach normal high value 28 people, reach normal arterial pressure 81 people, reach ideal bp 62 people.
Low danger group: 542 people reach normal group 39 people, reach desirable group 503 people;
Middle danger group: 873 people reach low danger and organize 21 people, reach normal group 274 people;
High-risk group: danger was organized 8 people during 298 people reached, and reached low danger and organized 19 people, reached normal group 110 people, reached desirable group 161 people;
High danger group: reach high-risk group 20 people, danger is organized 50 people in reaching, and reaches low danger and organizes 22 people, reaches normal group 57 people, reaches desirable group 43 people.Therapeutic effect of the present invention is remarkable.Simultaneously, the relevant disease that apoplexy, coronary heart disease, headache, hypertension such as dizzy are caused also has better curative effect, and can blood sugar lowering, blood fat, blood be sticking, effective percentage is about 75%.
The specific embodiment
Take by weighing raw material by following proportioning: Semen Persicae 16g, Radix Platycodonis 6.5g, Concha Haliotidis 22.5g, Flos Carthami 12g, Radix Bupleuri 4g, Fructus Gardeniae 12g, Radix Angelicae Sinensis 12g, Fructus Aurantii 8g, Poria cum Radix Pini 12g, Radix Rehmanniae 12g, Radix Glycyrrhizae 4g, Radix Scutellariae 12g, Rhizoma Chuanxiong 6g, Rhizoma Gastrodiae 12g, Cortex Eucommiae 12g, Radix Paeoniae Rubra 8g, Ramulus Uncariae Cum Uncis 25g, Herba Leonuri 12g, Radix Cyathulae 12g, Semen Cassiae 22.5g, Herba Taxilli 12g, Caulis Polygoni Multiflori 12g.
Production method is as follows: the Cortex Eucommiae is selected the burnt Cortex Eucommiae.Get above-mentioned 22 flavor Chinese medicines and pulverize, cross 80 mesh sieves, make medicated powder, medicated powder is inserted in the container, add 140 distilled water that restrain by per 100 gram medicated powder, be heated to temperature 80-90 ℃, insulation 10-15 hour, make the medicine slurry, with 520 type hydraulic pressure pressure filter, squeeze and filter goes out whole medicine juice from the medicine slurry, adds the Mel that accounts for medicine juice gross weight 0.5% again, stir, become 10mlx10 to prop up/box with the PVC/YE composite film packaging.Oral, a 50ml, three times on the one, 15 days one courses of treatment.
Claims (3)
1, the hypertensive Chinese medicine oral liquid of a kind of treatment is characterized in that comprising what the following weight proportion raw material was made:
25~30 parts of 5~8 parts of Concha Haliotidis of 12~20 parts of Radix Platycodoniss of Semen Persicae
9~15 parts of 3~5 portions of Fructus Gardeniaes of 9~15 parts of Radix Bupleuri of Flos Carthami
9~15 parts of 6~10 parts of Poria cum Radix Pinis of 9~16 parts of Fructus Aurantiis of Radix Angelicae Sinensis
9~15 parts of 3~5 parts of Radix Scutellariaes of 9~15 portions of Radix Glycyrrhizaes of Radix Rehmanniae
9~15 parts of 9~15 parts of Cortexs Eucommiae of 5~8 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
9~15 parts of 20~30 parts of Herba Leonuris of 6~9 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
9~15 parts of 25~30 parts of Herba Taxillis of 6~15 parts of Semen Cassiaes of Radix Cyathulae
9~15 parts of Caulis Polygoni Multiflori.
2, the hypertensive Chinese medicine oral liquid of a kind of treatment according to claim 1 is characterized in that comprising that wherein the weight proportion of each raw material is:
21~25 parts of 6~7 parts of Concha Haliotidis of 14~18 parts of Radix Platycodoniss of Semen Persicae
10~14 parts of 3~4 portions of Fructus Gardeniaes of 10~14 parts of Radix Bupleuri of Flos Carthami
10~14 parts of 7~9 parts of Poria cum Radix Pinis of 10~14 parts of Fructus Aurantiis of Radix Angelicae Sinensis
10~14 parts of 3~4 parts of Radix Scutellariaes of 10~14 portions of Radix Glycyrrhizaes of Radix Rehmanniae
10~14 parts of 10~14 parts of Cortexs Eucommiae of 6~7 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
10~14 parts of 23~27 parts of Herba Leonuris of 7~8 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
10~14 parts of 26~27 parts of Herba Taxillis of 7~14 parts of Semen Cassiaes of Radix Cyathulae
10~14 parts of Caulis Polygoni Multiflori.
3, the hypertensive Chinese medicine oral liquid of a kind of treatment according to claim 1 is characterized in that comprising that wherein the weight proportion of each raw material is:
22.5 parts of 6.5 parts of Concha Haliotidis of 16 parts of Radix Platycodoniss of Semen Persicae
12 parts of 4 portions of Fructus Gardeniaes of 12 parts of Radix Bupleuri of Flos Carthami
12 parts of 8 parts of Poria cum Radix Pinis of 12 parts of Fructus Aurantiis of Radix Angelicae Sinensis
12 parts of 4 parts of Radix Scutellariaes of 12 portions of Radix Glycyrrhizaes of Radix Rehmanniae
12 parts of 12 parts of Cortexs Eucommiae of 6 parts of Rhizoma Gastrodiaes of Rhizoma Chuanxiong
12 parts of 25 parts of Herba Leonuris of 8 parts of Ramulus Uncariae Cum Uncis of Radix Paeoniae Rubra
12 parts of 22.5 parts of Herba Taxillis of 12 parts of Semen Cassiaes of Radix Cyathulae
12 parts of Caulis Polygoni Multiflori.
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CNB2006101650074A CN100464775C (en) | 2006-12-12 | 2006-12-12 | Chinese medicinal oral liquid for treating hypertension |
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CNB2006101650074A CN100464775C (en) | 2006-12-12 | 2006-12-12 | Chinese medicinal oral liquid for treating hypertension |
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Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101417087B (en) * | 2008-11-13 | 2011-08-10 | 王督 | Medicine for treating gynecology postpartum disease and preparation method thereof |
CN102018892B (en) * | 2010-11-24 | 2012-05-23 | 伯风京 | Chinese medicinal composition for treating vertigo caused by hypertension |
CN102370809B (en) * | 2011-10-16 | 2013-06-05 | 广东养美医药投资有限公司 | Self-heated traditional Chinese medicine (TCM) emplastrum for preventing and curing hypertension |
CN102423421B (en) * | 2011-12-06 | 2014-06-11 | 陈中元 | Medicine for treating hypertension |
CN103055164B (en) * | 2012-12-26 | 2014-08-20 | 中国中医科学院中医临床基础医学研究所 | Traditional Chinese medicine composition for treating isolated diastolic hypertension |
CN104069243A (en) * | 2014-06-27 | 2014-10-01 | 冯书德 | Medicine for treating hypertension and preparation method thereof |
CN104873896A (en) * | 2015-05-26 | 2015-09-02 | 李厚建 | Traditional Chinese medicine composition for treating stroke caused by hypertension |
CN106421020A (en) * | 2016-10-10 | 2017-02-22 | 徐凤芹 | Ligusticum chuanxiong-Gardenia jasminoides oral preparation and preparation method thereof |
CN107669946A (en) * | 2017-11-25 | 2018-02-09 | 衡阳县华盛达农林科技有限公司 | Sophora bud traditional Chinese medicine oral liquid and preparation method thereof |
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2006
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Non-Patent Citations (2)
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中医药治疗高血压病的研究概况. 刘福明,王忠良.湖北中医杂志,第3卷第8期. 2001 * |
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