CN101534719A - Retractable segmented bio-molecular collector swab system - Google Patents
Retractable segmented bio-molecular collector swab system Download PDFInfo
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- CN101534719A CN101534719A CNA2007800409149A CN200780040914A CN101534719A CN 101534719 A CN101534719 A CN 101534719A CN A2007800409149 A CNA2007800409149 A CN A2007800409149A CN 200780040914 A CN200780040914 A CN 200780040914A CN 101534719 A CN101534719 A CN 101534719A
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Abstract
A segmented collector swab system includes a skewer and a plurality of absorbent pads assembled on the skewer in a kebobbed manner.
Description
Technical field
The present invention relates to a kind of equipment, be used for collecting, transport and preserve the bio-molecular diagnostics sample, for example, be used for oral fluid, genomic DNA, oral cavity cell DNA or analog that bio-molecular diagnostics test and court's genome are identified request.
About heredity and court's genome qualification test, being realized vestibule of mouth for a long time is collect saliva DNA and oral cavity cell DNA sample local easily.From medical science anatomy, the vestibule of mouth of mouth is between buccal inboard and dental bed tooth.Nearest research has shown from saliva or the dna sample of sloughing off oral cavity tissue has the same good quality with the blood DNA sample.
Up to now, sampling of non-blood molecule DNA and parental generation identify, scene of a crime investigation, major criminal's feature and court evidence analysis from time of collecting up to action that usually need a plurality of steps in lab analysis.Like this, these programs in the high power capacity laboratory, need time-consuming a plurality of steps, comprise rapid draing, accurately cutting and the preservation that effectively distributes and may remain untested absorbent patch or disk.
Collecting from vestibule of mouth the process of dna sample, absorbent patch is uncommon in friction on the cheek mucosal of oral cavity to cause mechanically that tissue is sloughed off and to attract and absorb on the pre-cut absorption segmentation disk.
In the molecule DNA analytical technology, the collection of a plurality of samples is absolute important.Equipment of the prior art has also utilized single big absorbent patch, and it must use expensive and heavy machinery cutting or punching afterwards.This needs the operation of additive decrementation time, and may cause sample cross contamination, and it will influence the serious legal consequences of any DNA evidence.
Comprise a kind of fully-integrated multifunctional equipment according to biomolecule collection of the present invention, transportation, distribution and saved system.This catcher comprises as follows:
Prepackage is loaded with the equipment of a plurality of sectional absorption disks or pad, can provide a plurality of samples with the equipment of guaranteeing sample integrity by using a color codeization or bar codeization.
This equipment can be assigned to the disk that is attached with DNA in the specific DNA test tube in order, fast, accurately.
This equipment be sealing, the system of self-sustaining to be to guarantee health, and is prior, eliminate the cross-contamination of sample and alter, in one embodiment of the invention, can utilize individual equipment to connect two groups of samples, one group is used for laboratory test, the purpose that another group is used to file.
At last, this equipment is easy to use by ergonomic design.
Summary of the invention
According to segmented collector swab system of the present invention, generally include skewer shape thing and be installed to a plurality of absorbent patch or disk on the skewer shape thing in the mode of shishkabab.Each pad can separate with adjacent pad from skewer shape thing.This system can comprise back-to-back swab, is used to obtain two groups of samples, and one group is used for test, the purpose that another group is used to file.
More particularly, this system may further include a plurality of partitions that are arranged between the pad adjacent on the skewer shape thing.In addition, a flange or sleeve pipe can provide the fixing device that is arranged on this end of skewer shape thing to be arranged on the skewer shape thing with relation at interval with skewer shape thing one end, are used for holding a plurality of pads and a plurality of partition between flange or sleeve and fixing device end.Fixing device is detachable, and permission pad mode in order distributes from skewer shape thing respectively, can selectablely be kept in one or more diagnostic test apparatus at a plurality of samples that are distributed in after the collection on each pad like this.
In one embodiment, utilize sleeve pipe from skewer shape thing sliding shim or disk, interchangeable, can provide fork to be used for separating and removing each pad from skewer shape thing.Each pad can comprise softish, an AT zigzag periphery, is used for the scraping tissue to promote collecting sample from for example mucosa.In order to promote sample collection, the diameter that each partition has less than contiguous with it pad contacts with histiocytic to guarantee pad.
In another embodiment of the present invention, this collection swab system further comprises handle, supports the end that skewer shape thing protrudes from this handle.
A plurality of absorbent patch or disk are installed to skewer shape thing protruding end in the mode of shishkabab, and each pad can separate with adjacent pads from skewer shape thing protruding end.
Further, provide distributor gear to be used for skewer shape thing protruding end is withdrawn in the handle, force thus each pad in order mode leave skewer shape thing protruding end, wherein disk is saved in the suitable testing equipment rapidly safely.This mechanism can be, for example, is arranged on pieceable screw on screw on the skewer shape thing and the handle.In this way, the rotation of handle can make skewer shape thing protruding end be withdrawn in the handle, and each pad is forced to and leaves skewer shape thing, as previously described.
In another embodiment of the present invention, segmented collection device system comprises the elongate enclosure with opening, with the skewer shape thing that slidably is arranged in the elongate enclosure.
Be installed to a plurality of absorbent patch or disk on the skewer shape thing in the mode of shishkabab, each pad can separate with adjacent pads from skewer shape thing.More particularly, provide skewer shape thing mobile piston, but it is arranged in the elongate enclosure and comprises the abutting end that is arranged near elongate enclosure one end.Plunger handle is provided, but its detachablely engage with the piston abutting end, be used to realize the manual slip of skewer shape thing and pad in elongate enclosure the position and the position of elongate enclosure other end outside between move.
Provide detachable enclosure cap in order to the sealing elongate enclosure.
More particularly, plunger handle can comprise and is kept at the pipe between skewer shape thing and elongate enclosure medial surface in the elongate enclosure.
In addition, this system can comprise the bottle that contains activator that is connected to shell, is used for activator is directed to skewer shape thing pad.
A plurality of partitions can be provided and be arranged between the skewer shape thing adjacent pads, a flange or sleeve pipe can be to be arranged on the skewer shape thing with relation at interval with skewer shape thing one end.One fixing device can be arranged on this end of skewer shape thing, is used for holding between flange and fixing device a plurality of pads and a plurality of partition.
As previously described, this embodiment also can be included in to distribute or preserve pad or disk and be used for fork that each pad is separated and removes from skewer shape thing during in the test tube.
Interchangeable, this system can comprise handle, supports the end that skewer shape thing protrudes from this handle.In this embodiment, absorbent patch or disk are installed in skewer shape thing protruding end and provide mechanism to be used for skewer shape thing protruding end is withdrawn into handle, force each pad to leave skewer shape thing protruding end thus.
According to a kind of method of collecting multiple sample of the present invention, generally include the absorbent patch of barbecue string data on the skewer shape thing is exposed to specimen collection site, the oral cavity, inside of corners of the mouth side for example, then the pad of barbecue string data friction on the oral mucosa with dense sample collection be transferred on the disk.
Then, pad removes respectively from the sampling spot withdrawal and from skewer shape thing, so that the multiple pad that comprises sample to be provided.
Description of drawings
Consider together with accompanying drawing that by following detailed the present invention can understand by easier quilt, wherein:
Fig. 1 is according to the plane graph of segmented collection swab of the present invention system, shows back-to-back detachable swab, and each has the pad and the lid of handle, skewer shape thing, barbecue string data;
Fig. 2 is an exploded perspective illustration, shows skewer shape thing and a plurality ofly is installed to absorbent patch on the skewer shape thing in the shishkabab mode;
Fig. 3 shows a part utilizing two back-to-back detachable gathering systems shown in Fig. 1, collects the genomic DNA sample from crime field location, vaginal secretion the sexual violence case and vestibule of mouth (not shown).After the first's sampling with catcher, the disk of barbecue string data covers with airy lid, uses the second portion of collector device to repeat identical collection procedure then.These two identical parts of gathering system unclamp or separate at the center line joint.Each applicator system that is built is transported to laboratory and/or grandfatherd equipment then;
Fig. 4 shows and is distributing or preserve absorbent patch and be saved in the test tube from skewer shape thing behind the sample collection, and skewer shape thing and test tube are all used bar code identification;
Fig. 5 shows and uses fork from skewer shape thing separate absorbent pad;
Fig. 6 is the viewgraph of cross-section of an embodiment, and skewer shape thing and barbecue string data pad are arranged in the ventilation shell, with the detachable enclosure cap that is used to seal shell;
Fig. 7 shows when wanting analyzed afterwards in the time-sensitive program, and the reactant bottle is connected to shell, reactant is sucked the absorption sample pad generation intermediate reaction on shell and the skewer shape thing, is used to protect the sample on it;
Fig. 8 is the viewgraph of cross-section of another embodiment of the present invention, and wherein handle comprises that the pipe that is used to insert between shell skewer shape thing and the shell is to provide compact system;
Fig. 9 shows system shown in Figure 8, and handle is removed in shell, and being connected with plunger, to be used for that skewer shape thing and pad are stretched out shell outer and skewer shape thing withdrawn in the shell, as shown in Figure 9; And
Figure 10 is another embodiment of the present invention, and cork screw mechanism further is provided, and is used for skewer shape thing is withdrawn in the handle by rotation, supports the pad of skewer shape thing with compressing skewer shape thing when skewer shape thing is withdrawn in the handle.
The specific embodiment
About accompanying drawing 1-2, show that a kind of it generally includes skewer shape thing 12 and a plurality of absorbent patch or disk 16 according to segmented collection swab of the present invention system 10, only some is with Digital ID, and the quantity of pad 16 can be any quantity of wanting.
In order to promote pad 16 exposing to the open air and, partition 22 can be set between absorbent patch 16 in the DNA tissue adherence in the absorption of specimen collection site.This realizes less than the partition 22 of the diameter of adjacent pads 16 by diameter is provided.
In order to promote cell to slough off and concentration of specimens, each pad 16 can have softish, AT zigzag peripheral 24 (Fig. 2).
Can provide cowling 34 to be used for before collecting sample and protect pad 16 afterwards.Lid also is used as the transport enclosure of the protectiveness easily of collector device.The ventilation perforation of tops is in order during transportation to accelerate the disk dry run.
It should be understood that system 10 provides the genome analysis sampling equipment, it is used for court's genotype, for example bone marrow donor genotype, veterinary's genotype, paternity identification, migrate that father and mother identify, the sexual offender feature, also be used for natural disaster and battlefield and identify.
When being used for paternity identification, during promptly clinical genotype, pad 16 and handle 28 can be father, mother and each equipment of child's preliminary election by color codeization like this.Can provide plane 40 to be used for the joint strip font code to guarantee the integrity of taking a sample.
Fig. 3 shows system 10, is used for obtaining oral cavity dna sample (not shown) when it is inserted into mouth 52.Fig. 3 only shows a kind of mode of sample collection.Zigzag is collected pad 16 and can be rubbed or beat with what guarantee high concentration on each pad 16 at the vestibule of mouth (not shown) and slough off cell and best absorption dna sample.
As shown in Figure 4, behind sample collection, the pad 16 on the skewer shape thing can be transported to laboratory.At laboratory, fixing device 36 is removed from skewer shape thing 12 by cutting off or reversing fixing device 36, to skewer shape thing end 38 sliding sleeves 32.This mechanism is assigned to 56 li in test tube to disk 16.
Interchangeable, as shown in Figure 5, can utilize and distribute fork 58 to separate pad 16 respectively to be saved in separately test tube 56.It should be understood that and once can remove any amount of pad 16.
In addition, or as an alternative, for above-mentioned color codeization, bar code 62 is provided for handle 28, corresponding to the bar code that is arranged on the corresponding test tube 56 about paternity identification.
About Fig. 6, shell 42 can be provided, its hold skewer shape thing 12 pads 16 and partition 22 and and skewer shape thing piston 44 together, and be sealed in the elongate enclosure 42 by enclosure cap 46,48.This closed system is suitable for providing not contaminated condition before this system of use and after using this systematic collection sample.
Among Fig. 7, plunger handle 50 is detachable to be engaged with skewer shape thing piston 44, realizes the manual slip of skewer shape thing 12 in shell.
If desired; as shown in Figure 7; sample pad 16 can be processed, protection or with reactant 66 reactions from reactant bottle 68; described bottle is connected to an end 70 of shell 42; by piston by plunger handle 50 moving belt skewer shape things and pad 16; perhaps sample pad 16,18 is immersed reactant 16, perhaps through the reactant bottle 68 sucting reaction agent of plunger handle 50, shown in arrow 72 from connecting.
Shown in Fig. 8 and 9, identical or substantially similar parts use and the identical Reference numeral that proposes in the description of system 10 one segmented collector swab system 76 of replacing with cross section.
Among Fig. 8, this system 76, handle 78 comprises the lid 80 that is used to seal elongate enclosure 42, also comprises the pipe 86 that is kept between elongate enclosure 42 interior skewer shape things 12 and shell 42 medial surface 86.As shown in Figure 8, this provides the system 76 of compact preservation.
In the use, as shown in Figure 9, pipe 86 removes in elongate enclosure 42, be connected to plunger 88, after pipe 86 is connected to plunger 88, its can make skewer shape thing 12 and the pad 16 installed shell 42 in the position and the position outside the shell 42 between manually slip, as shown in figure 10.
It should be understood that and to utilize any mechanism (not shown) in the skewer shape thing 98 withdrawal handles, with the pad 16 of compressing skewer shape thing.
A method according to the present present invention comprises the absorbent patch of barbecue string data on the skewer shape thing is exposed to specimen collection site, as shown in Figure 3, then pad is rubbed sloughing off on the pick-up point, attracts and transmit dna sample thereon.
Then, skewer shape thing and pad 16,18 are withdrawn together, and pad removes from skewer shape thing 12, so that the multiple pad 16 that comprises sample to be provided.
The front has been described according to a kind of specific segmented collection swab system and method for the present invention, although be in order to demonstrate the purpose of the advantage of using method of the present invention, to should be appreciated that to the invention is not restricted to those.That is to say that comprise element or (in essence) enumerated that the present invention can be suitable are made up of the element of enumerating.Further, suitable can being implemented of the present invention that discloses in the mode of illustrative here in the mode that lacks any element, it is not here done especially and discloses.Therefore any modification, variation or equivalent device can be utilized by those skilled in the art, should be considered to be included in the scope of accessory claim definition of the present invention.
Claims (21)
1. segmented collector swab system comprises:
Skewer shape thing; With
Be installed to a plurality of absorbent patch or disk on the described skewer shape thing in the mode of shishkabab, each pad can separate with adjacent pad from described skewer shape thing.
2, the system as claimed in claim 1 further comprises a plurality of partitions that are arranged between the pad adjacent on the described skewer shape thing.
3, system as claimed in claim 2 further comprises the fixing device that is arranged on described skewer shape thing one end, is used for holding on described skewer shape thing a plurality of pads and described a plurality of partition.
4, the system as claimed in claim 1 further comprises being used for each pad is separated and removes to distribution fork in the test tube from described skewer shape thing.
5, the system as claimed in claim 1, wherein each pad comprises the zigzag periphery, is used to promote the machinery scraping or sloughs off Stomatocyte.
6, system as claimed in claim 2, wherein each pad comprises the zigzag periphery, be used for the scraping tissue, and each partition has the diameter less than each pad diameter.
7, the system as claimed in claim 1 further comprises the distribution sleeve that is arranged on the described skewer shape thing, is used for skidding off pad from skewer shape thing during the DNA elution process and enters test tube.
8, a kind of segmented collector swab system comprises:
The hands handle;
By the skewer shape thing that described handle supports, has the end of protruding from described handle;
Be installed to a plurality of absorbent patch of skewer shape thing protruding end in the mode of shishkabab, each pad can separate with adjacent pad from skewer shape thing protruding end;
Be used for skewer shape thing protruding end is withdrawn into mechanism in the handle, force each pad to leave skewer shape thing protruding end.
9, system as claimed in claim 8, wherein this mechanism be included on the described skewer shape thing screw and in described handle pieceable screw.
10, a kind of segmented collector swab system comprises:
First handle;
By the first skewer shape thing that described first handle supports, has the end of protruding from described first handle;
Be installed to a plurality of first absorbent patch of the first skewer shape thing protruding end in the mode of shishkabab, each first pad can separate with the first adjacent pad from the first skewer shape thing protruding end;
Second handle;
By the second skewer shape thing that described second handle supports, has the end of protruding from described second handle;
Be installed to a plurality of second absorbent patch of the second skewer shape thing protruding end in the mode of shishkabab, each second pad can separate with the second adjacent pad from the second skewer shape thing protruding end;
First and second handles interconnect so that back-to-back relation is detachable, and the separating property of handle makes first absorbent patch be used to test and purpose that second absorbent patch is used to file.
11, a kind of segmented collector swab system comprises:
Elongate enclosure with opening;
Slidably be arranged on the skewer shape thing in the described elongate enclosure;
Be installed in a plurality of absorbent patch on the described skewer shape thing in the mode of shishkabab, each pad can separate with adjacent pad from described skewer shape thing;
Skewer shape thing mobile piston is arranged in the described elongate enclosure, but has the abutting end that is arranged near described elongate enclosure one end;
Plunger handle, but detachablely engage with the piston abutting end, the pad that is used to realize described skewer shape thing and installation in described elongate enclosure the position and the manual slip between the position of described elongate enclosure other end outside; With
In order to seal the detachable enclosure cap of described elongate enclosure.
12, system as claimed in claim 11, wherein said plunger handle comprise and are kept at the pipe between described skewer shape thing and described elongate enclosure medial surface in the described elongate enclosure.
13, system as claimed in claim 11 further comprises the bottle that contains activator, is connected to be used on the shell activator is directed to skewer shape thing pad.
14, system as claimed in claim 11 further comprises a plurality of partitions that are arranged between the pad adjacent on the described skewer shape thing.
15, system as claimed in claim 14, further comprise to be arranged on flange on the described skewer shape thing with at interval relation with described skewer shape thing one end, and be arranged on fixing device on the described end of described skewer shape thing, be used between described flange and described fixing device end, holding a plurality of pads and described a plurality of partition.
16, system as claimed in claim 11 further comprises being used for fork that each pad is separated and removes from described skewer shape thing.
17, system as claimed in claim 11, wherein each pad comprises the zigzag periphery of the tissue that is used to swipe.
18, system as claimed in claim 14, wherein each pad comprises the zigzag periphery, be used for the scraping tissue, and each partition has the diameter less than each pad diameter.
19, system as claimed in claim 11, further comprise handle, be used for supporting described skewer shape thing by an end of the described skewer shape thing that protrudes from described handle, described absorbent patch is installed on the skewer shape thing protruding end, and be used for skewer shape thing protruding end is withdrawn into mechanism in the handle, be used to force each pad to leave skewer shape thing protruding end.
20, system as claimed in claim 19, wherein this mechanism be included on the described skewer shape thing screw and in described handle pieceable screw.
21, a kind of method that is used to collect multiple sample, described method comprises:
The absorbent patch of barbecue string data on the skewer shape thing is exposed to the sample location;
Pad is rubbed on this location to transmit the sample on it;
From this location withdrawal pad;
Remove pad from skewer shape thing, so that the multiple pad that comprises sample to be provided.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84283806P | 2006-09-06 | 2006-09-06 | |
| US60/842,838 | 2006-09-06 | ||
| US11/848,851 | 2007-08-31 |
Publications (1)
| Publication Number | Publication Date |
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| CN101534719A true CN101534719A (en) | 2009-09-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200780041296XA Pending CN101611134A (en) | 2006-09-06 | 2007-09-04 | Utilize the reliable self-contained bio-molecular sampling and transportation system of docking mechanism |
| CNA2007800409149A Pending CN101534719A (en) | 2006-09-06 | 2007-09-04 | Retractable segmented bio-molecular collector swab system |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200780041296XA Pending CN101611134A (en) | 2006-09-06 | 2007-09-04 | Utilize the reliable self-contained bio-molecular sampling and transportation system of docking mechanism |
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| CN (2) | CN101611134A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618642A (en) * | 2015-11-04 | 2017-05-10 | 莫伊舍·博德纳 | Splittable fluid sample collector |
| CN111498246A (en) * | 2019-01-31 | 2020-08-07 | 莹芳有限公司 | Sampling and inspecting container |
| CN111616749A (en) * | 2020-06-04 | 2020-09-04 | 中国人民解放军西部战区总医院 | Liver biopsy puncture needle capable of sampling multiple depths simultaneously |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104777012B (en) * | 2015-04-15 | 2017-11-24 | 戚本昊 | A kind of disposable pretreatment self-distroyable disposable urine liquid sampler and preparation method thereof |
| CN106281992B (en) * | 2015-05-18 | 2024-02-09 | 北京慧荣和科技有限公司 | Full-automatic Ames experiment instrument |
-
2007
- 2007-09-04 CN CNA200780041296XA patent/CN101611134A/en active Pending
- 2007-09-04 CN CNA2007800409149A patent/CN101534719A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106618642A (en) * | 2015-11-04 | 2017-05-10 | 莫伊舍·博德纳 | Splittable fluid sample collector |
| CN111498246A (en) * | 2019-01-31 | 2020-08-07 | 莹芳有限公司 | Sampling and inspecting container |
| CN111498246B (en) * | 2019-01-31 | 2022-02-22 | 莹芳有限公司 | Sampling and inspecting container |
| CN111616749A (en) * | 2020-06-04 | 2020-09-04 | 中国人民解放军西部战区总医院 | Liver biopsy puncture needle capable of sampling multiple depths simultaneously |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101611134A (en) | 2009-12-23 |
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Open date: 20090916 |