CN101524499A - Gynecological lotion and preparation method thereof - Google Patents
Gynecological lotion and preparation method thereof Download PDFInfo
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- CN101524499A CN101524499A CN200910038551A CN200910038551A CN101524499A CN 101524499 A CN101524499 A CN 101524499A CN 200910038551 A CN200910038551 A CN 200910038551A CN 200910038551 A CN200910038551 A CN 200910038551A CN 101524499 A CN101524499 A CN 101524499A
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Abstract
The invention discloses a gynecological lotion and a preparation method thereof. The gynecological lotion contains the active ingredients of raw materials by weight parts: 2-3 of cloves, 3-5 of pepper, 10-15 of cnidium, 3-5 of mint, 10-15 of salvia, 7-9 of radixstemonae, 10-15 of smilax, 5-8 of white moss leather, 7-9 of sophora, 4-6 of Phellodendron, 3-5 of polygonum cuspidate, 4-6 of dandelion, 3-5 of berberine, 10-15 of fructuskochiae and 0.1-0.3 of borneol. The novel gynecological lotion consists of over ten Chinese herbs, has reasonable component prescription compatibility, can obviously reduce the number of vaginal disease-causing micro-organisms and the infection chances, and has more prominent effects of bacterial, fungal and trichomonas vaginitis caused by common micro-organisms.
Description
Technical field
The present invention relates to a kind of gynaecologic washing lotion and preparation method thereof.
Background technology
Various vaginitiss that caused by pathogen such as antibacterial, gonococcus, mycete and infusorian and external genitalia official's inflammation often perplex a lot of women, make that its life is painful, spirit is unhappy.Incomplete statistics according to World Health Organization (WHO), various gynaecopathia sickness rate are more than 65% among the women, China's interrelated data investigation shows, women of child-bearing age's disease incidence is more than 70%, the women is 100% vaginitis of suffering from various degree almost in life, and wherein having more than 5% due to illness, feelings have had a strong impact on normal work and life.Market survey according to washing liquid, mainly contain products such as the scorching clean washing liquid of woman, JIEERYIN XIYE, Dianthus carryophyllus washing liquid, the peaceful washing liquid of health woman at present, in China's Urban Women, 32% women uses often, 25% women uses every day, and 58% women used 1 time in one week at least, and 19% female menstrual period uninterruptedly uses, 91% people selects Chinese medicine or plant type washing liquid, and 5% women regularly does vaginadouche.Existing various gynaecologic washing lotion, it is few that ubiquity drug component, and compatibility is unreasonable, and the efficacy of a drug is weak, weak curative effect.
Summary of the invention
The object of the present invention is to provide a kind of gynaecologic washing lotion, this gynaecologic washing lotion is a pure Chinese medicinal preparation, its fungistatic effect is strong, onset rapidly, have no side effect, health environment-friendly.
The raw materials of effective components weight portion of making described gynaecologic washing lotion consists of: Flos Caryophylli 2-3, Pericarpium Zanthoxyli 3-5, Fructus Cnidii 10-15, Herba Menthae 3-5, Radix Salviae Miltiorrhizae 10-15, Radix Stemonae 7-9, Rhizoma Smilacis Chinensis 10-15, Cortex Dictamni 5-8, Radix Sophorae Flavescentis 7-9, Cortex Phellodendri 4-6, Rhizoma Polygoni Cuspidati 3-5, Herba Taraxaci 4-6, Rhizoma Coptidis 3-5, Fructus Kochiae 10-15, Borneolum Syntheticum 0.1-0.3.
Another purpose of the present invention is to provide the preparation method of this gynaecologic washing lotion.
Described gynaecologic washing lotion prepares by following steps:
A with the Radix Stemonae of described weight portion, Radix Salviae Miltiorrhizae with 60-80% alcohol reflux 2 times,, filter, merging filtrate, medicinal residues are standby;
B with the Flos Caryophylli of described weight portion, Fructus Cnidii, Herba Menthae, Pericarpium Zanthoxyli with water extraction volatile oil 1 time, each 2-4 hour, collect volatile oil, standby;
Continue to collect 0.5 times of oil-water mixture of medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby;
C is with Rhizoma Smilacis Chinensis, Cortex Dictamni, Radix Sophorae Flavescentis, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Rhizoma Coptidis, the Fructus Kochiae and the Radix Stemonae, the Radix Salviae Miltiorrhizae decoction dregs of described weight portion, and Flos Caryophylli, Fructus Cnidii, Herba Menthae, Pericarpium Zanthoxyli medicinal residues extract 2-4 time each 1 hour with 8-12 times of water gaging, filter, merging filtrate is abandoned medicinal residues, filtrate for later use;
The medicinal liquid that D makes A, B, C step merges, and when being concentrated into the suitable crude drug in whole 1-1.4g of every 1ml, adds 95% ethanol, makes to contain the alcohol amount and be 60-80%, leaves standstill 24 hours, gets supernatant, reclaims ethanol, is concentrated into an amount of, standby;
E merges prepared volatile oil among above-mentioned concentrated solution, the B, adds Borneolum Syntheticum, and mix homogeneously is diluted with water to corresponding requirement again, and the pH scope is 4-6.
Preferably, described step e is: prepared volatile oil among gained concentrated solution, the step B among the step D is merged, add Borneolum Syntheticum, and appropriate amount of auxiliary materials, mix homogeneously is diluted with water to corresponding requirement (for example for the 1-2 of crude drug weight doubly) again, and the pH scope is 4-6.
Gynaecologic washing lotion fungistatic effect of the present invention is strong, onset is rapid.
The bacteriostatic test of described gynaecologic washing lotion, acute oral toxicity test and vaginal mucosa irritation result of the test are as follows:
Bacteriostatic test (to the antibacterial result of staphylococcus aureus, escherichia coli, Candida albicans)
With the diluent of described gynaecologic washing lotion stock solution and 33.3%, action time 2min, 5min, 10min, 20min, test repeats 3 times.
Negative control: diluent, the equal asepsis growth of culture medium
Result of the test shows, stock solution and 33.3% diluent are 100% effect 2 minutes and when above to the average bacteriostasis rate of staphylococcus aureus, escherichia coli and Candida albicans.
Acute oral toxicity test:
The result shows the acute oral toxicity LD50＞5000mg/kg BW of this product to male and female NIH mice, belongs to actual nontoxic level.
Vaginal mucomembranous irritant test:
Test method: set up to be subjected to examination group, vehicle group and blank group.Every group of 6 adult healthy female sd inbred rats.Soaked to be tried thing with suitably big or small sterilization absorbent cotton by the examination group places in the SD rat vagina, vehicle group is soaked sterile saline with onesize cotton sliver and is placed and tried in the SD rat vagina, all contact 24h with the animal vaginal mucosa, the blank group does not then give any processing.Put to death animal behind the 24h, take out whole vagina, observe hyperemia, the edema reacting phenomenon of local vagina tissue, carry out the irritant reaction evaluation.
Result of the test: be subjected to the local vagina tissue of examination group and matched group SD rat all not find abnormal responses such as hyperemia, edema, also do not find other symptoms.Vaginal mucosa irritation index+0.0.
The result shows that this product belongs to nonirritant to the vaginal mucosa irritation of female sd inbred rats.
The human clinical trial
Gynecological inflammation is many directly invade by antibacterial, Candida albicans, trichomonal vaginitis due to, also have because of some disease such as diabetes, or abuse of antibiotics causes that immunity of organisms is low that infection is brought out in intravaginal environment change etc.This gynaecologic washing lotion is made up of 10 pleasant impression Chinese medicines; it is a kind of pure natural disinfection washout cleaning solution; have the self-cleaning function of sterilizing and itch-relieving, antiinflammatory parasite killing, dispeiling pathogenic wind and removing dampness, heat-clearing and toxic substances removing, protection genital skin mucosa and the ability of defence pathogenic bacteria; microorganisms such as escherichia coli, staphylococcus aureus, Candida albicans there is strong bacteriostasis, is used for the daily physiology of women and keeps a public place clean and the hygiene nursing.Through the clinical observation result ideal, now report as follows:
1, case is selected:
Selected patient's 202 examples, the age is at 18～65 years old, bacterial vaginitis 65 examples wherein, colpitis mycotica 73 examples, trichomonal vaginitis 64 examples.Symptom and sign: all kinds of colpitic cardinal symptoms are leucorrhoea grow in quantity, pruritus vulvae, pain, can be with frequent micturition, dysurea or sexual anhedonia; Visible pudendum and vaginal mucosa hyperemia during inspection.Visible respectively when infusorian property or colpitis mycotica patient vaginal secretions microscopy to infusorian or fungus; Bacterial vaginitis BV checks positive.Exclusion standard: (1) age is under-18s or over-65s person; (2) suffers from serious cervical erosion person; (3) the pruritus vulvae person due to other internal medicine, the cutaneous diseases such as leukoplakia vulvae, Behcet disease, diabetes; (4) the serious heart, liver, kidney and hemopoietic system complication person are arranged; (5) age of sucking, gravidic women; (6) the multiclass medicine there is allergies person or irritated disease patient is arranged in the recent period; Used similar medicine person in (7) 4 weeks.(8) do not meet diagnostic criteria, do not use given the test agent on request, can't judge effect or data not umbra sound effect or safety judgement person.
2, using method: vaginadouche, the stock solution 5-10ml that gets the gynaecologic washing lotion for preparing directly pours into special-purpose irrigator, inserts vagina then, extrusion bottle washes, every day 1-2 time, each 2 minutes, matched group uses the scorching scaling of woman to treat, and using method is with the administration group.Do not use other medicines during the treatment, using 7 days continuously is a course of treatment, uses a post-evaluation course of treatment curative effect.
3, curative effect is judged: recovery from illness: subjective symptoms disappears, vagina cleanness degree (I), and vaginal swab is cultivated and is turned out cloudy; Effectively: subjective symptoms alleviates, and vagina cleanness degree (II), vaginal swab are cultivated has only the minority bacterial growth, is no more than 10 at most; Invalid: subjective symptoms does not have improvement, the vagina cleanness degree no change, and vaginal swab is cultivated no change.
4, therapeutic outcome:
5, discuss
Gynecological inflammation is a common clinical in the gynaecopathia, this type of state of an illness is longer, the state of an illness is shown effect repeatedly, the state of an illness is obstinate, have a strong impact on women's physical and mental health, even have a strong impact on life and work, gynaecologic washing lotion of the present invention is made up of 10 kinds of traditional Chinese medicines, the prescription compatibility is reasonable, can obviously reduce the quantity of vagina pathogenic microorganism, reduce infection chance, be a kind of novel gynaecologic washing lotion, caused bacillary to common microorganism, mycotic, trichomonal vaginitis has outstanding curative effect, there is no tangible untoward reaction during the medication, to the vaginal mucosa nonirritant, do not see systemic anaphylaxis yet.The patient feels comfortable after the clinic trial, and dosage form is easy to use.Therefore, gynaecologic washing lotion of the present invention has good prospect at aspects such as prevention and treatment gynecological inflammations.
Product of the present invention is to teach combination clinical experience for many years by applicant-Dongfang Yaolinyaoyeyouxiangongsi and Nanfang Medical Univ's gynaecologist, mostly be deficiency in origin and excess in superficiality according to gynecological's pathology, according to Traditional Chinese medical theory " heat clearing away warms up palace, using medicines of both cold and hot natures simultaneously, disappear mend with execute, treating both the principal and the secondary aspects of a disease at the same time " the health care principle, selected tens flavor natural plant crude drugs prescriptions; A pure Chinese medicine maintenance type conditioning liquid that develops with great concentration according to international technology of modern times by Dongfang Yaolinyaoyeyouxiangongsi; Adopt advanced TLC bioautography technology, effective ingredient in the prescription is screened, determines, refines, form the pure Chinese medicine compound elite of efficient stable, overcome the defective that produced symptoms such as cold womb discomfort after gynaecologic washing lotion used in the past, initiative " warm palace " New Times; And by the unified production in the CR production workshop of GMP authentication, fill.
This product at the women when the menstrual period special body constitution and design, for improving women's " cold womb " symptom, full side is the center with the warm palace of warming YANG, have the effect of significant anti-inflammation concurrently, the nursing of emphasis Chinese medicine, really accomplish to support " palace ", protect " palace ", make the women obtain more thoughtful, more fully care in menstrual period.
The specific embodiment
Embodiment one:
Radix Stemonae 4.5kg, Radix Salviae Miltiorrhizae 5kg measure 80% alcohol reflux 2 times with 6 times, and each 2 hours, filter, merging filtrate, medicinal residues are standby.
Flos Caryophylli 1kg, Fructus Cnidii 5kg, Herba Menthae 1.5kg, Pericarpium Zanthoxyli 1.5kg extract volatile oil 1 time with 10 times of water gagings, and each 2 hours, collect volatile oil, standby; Continue to collect 0.5 times of oil-water mixture of medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby.
Rhizoma Smilacis Chinensis 6kg, Cortex Dictamni 2.5kg, Radix Sophorae Flavescentis 3.5kg, Cortex Phellodendri 3kg, Rhizoma Polygoni Cuspidati 1.5kg, Herba Taraxaci 3kg, Rhizoma Coptidis 1.5kg, Fructus Kochiae 7.5kg and the Radix Stemonae, Radix Salviae Miltiorrhizae decoction dregs, medicinal residues such as Flos Caryophylli, Fructus Cnidii extract 3 times with 10 times of water gagings, each 1 hour, filter, merging filtrate, abandon medicinal residues, filtrate for later use.
Medicinal liquid is merged, when being concentrated into the suitable crude drug in whole 1.2g of every 1ml, add 95% ethanol, make that to contain the alcohol amount be 75%, left standstill 24 hours, get supernatant, reclaim ethanol, be concentrated into an amount of, standby.
Concentrated solution, volatile oil are merged, add Borneolum Syntheticum 50g, mix homogeneously, thin up are to 50000ml, and pH value is 4.
Embodiment two:
Radix Stemonae 3.5kg, Radix Salviae Miltiorrhizae 7.5kg measure 60% alcohol reflux 2 times with 6 times, and each 2 hours, filter, merging filtrate, medicinal residues are standby.
Flos Caryophylli 1kg, Fructus Cnidii 6kg, Herba Menthae 2.5kg, Pericarpium Zanthoxyli 2.5kg extract volatile oil 1 time with 10 times of water gagings, and each 2 hours, collect volatile oil, standby; Continue to collect 0.5 times of oil-water mixture of medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby.
Rhizoma Smilacis Chinensis 7.5kg, Cortex Dictamni 3kg, Radix Sophorae Flavescentis 3.5kg, Cortex Phellodendri 2kg, Rhizoma Polygoni Cuspidati 2kg, Herba Taraxaci 2kg, Rhizoma Coptidis 2.5kg, Fructus Kochiae 5kg and the Radix Stemonae, Radix Salviae Miltiorrhizae decoction dregs, medicinal residues such as Flos Caryophylli, Fructus Cnidii extract 3 times with 8 times of water gagings, each 1 hour, filter, merging filtrate is abandoned medicinal residues, filtrate for later use.
Medicinal liquid is merged, when being concentrated into the suitable crude drug in whole 1.2g of every 1ml, add 95% ethanol, make that to contain the alcohol amount be 70%, left standstill 24 hours, get supernatant, reclaim ethanol, be concentrated into an amount of, standby.
Concentrated solution, volatile oil are merged, add Borneolum Syntheticum 100g, other right amount of auxiliary materials, mix homogeneously, thin up are to 50000ml, and pH value is 4.4.
Embodiment three:
Radix Stemonae 4kg, Radix Salviae Miltiorrhizae 6kg measure 70% alcohol reflux 2 times with 8 times, and each 2 hours, filter, merging filtrate, medicinal residues are standby.
Flos Caryophylli 1.5kg, Fructus Cnidii 6kg, Herba Menthae 2kg, Pericarpium Zanthoxyli 1.5kg extract volatile oil 1 time with 8 times of water gagings, and each 2 hours, collect volatile oil, standby; Continue to collect 0.5 times of oil-water mixture of medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby.
Rhizoma Smilacis Chinensis 5kg, Cortex Dictamni 3.5kg, Radix Sophorae Flavescentis 4.5kg, Cortex Phellodendri 2.5kg, Rhizoma Polygoni Cuspidati 2.5kg, Herba Taraxaci 2.5kg, Rhizoma Coptidis 2kg, Fructus Kochiae 6.5kg and the Radix Stemonae, Radix Salviae Miltiorrhizae decoction dregs, medicinal residues such as Flos Caryophylli, Fructus Cnidii extract 3 times with 12 times of water gagings, each 1 hour, filter, merging filtrate, abandon medicinal residues, filtrate for later use.
Medicinal liquid is merged, when being concentrated into the suitable crude drug in whole 1.2g of every 1ml, add 95% ethanol, make to contain the alcohol amount and be 70-75%, left standstill 24 hours, get supernatant, reclaim ethanol, be concentrated into an amount of, standby.
Concentrated solution, volatile oil are merged, add Borneolum Syntheticum 100g, other right amount of auxiliary materials, mix homogeneously, thin up are to 50000ml, and pH value is 4.8.
Embodiment four:
Radix Stemonae 3.5kg, Radix Salviae Miltiorrhizae 5kg measure 80% alcohol reflux 2 times with 6 times, and each 2 hours, filter, merging filtrate, medicinal residues are standby.
Flos Caryophylli 1.5kg, Fructus Cnidii 7.5kg, Herba Menthae 1.5kg, Pericarpium Zanthoxyli 2.5kg extract volatile oil 1 time with 10 times of water gagings, and each 2 hours, collect volatile oil, standby; Continue to collect 0.5 times of oil-water mixture of medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby.
Rhizoma Smilacis Chinensis 6kg, Cortex Dictamni 4kg, Radix Sophorae Flavescentis 4.5kg, Cortex Phellodendri 2.5kg, Rhizoma Polygoni Cuspidati 1.5kg, Herba Taraxaci 2kg, Rhizoma Coptidis 1.5kg, Fructus Kochiae 5kg and the Radix Stemonae, Radix Salviae Miltiorrhizae decoction dregs, medicinal residues such as Flos Caryophylli, Fructus Cnidii extract 3 times with 10 times of water gagings, each 1 hour, filter, merging filtrate, abandon medicinal residues, filtrate for later use.
Medicinal liquid is merged, when being concentrated into the suitable crude drug in whole 1.2g of every 1ml, add 95% ethanol, make to contain the alcohol amount and be 70-75%, left standstill 24 hours, get supernatant, reclaim ethanol, be concentrated into an amount of, standby.
Concentrated solution, volatile oil are merged, add Borneolum Syntheticum 150g, other right amount of auxiliary materials, mix homogeneously, thin up are to 50000ml, and pH value is 5.0.
Above-listed detailed description is at the specifying of possible embodiments of the present invention, and this embodiment is not in order to limiting claim of the present invention, and the equivalence that all the present invention of disengaging do is implemented or change, all should be contained in the claim of this case.
Claims (3)
1, a kind of gynaecologic washing lotion is characterized in that, makes the raw materials of effective components weight portion and consists of:
Flos Caryophylli 2-3 part Pericarpium Zanthoxyli 3-5 part Fructus Cnidii 10-15 part Herba Menthae 3-5 part
Radix Salviae Miltiorrhizae 10-15 part Radix Stemonae 7-9 part Rhizoma Smilacis Chinensis 10-15 part Cortex Dictamni 5-8 part
Radix Sophorae Flavescentis 7-9 part Cortex Phellodendri 4-6 part Rhizoma Polygoni Cuspidati 3-5 part Herba Taraxaci 4-6 part
Rhizoma Coptidis 3-5 part Fructus Kochiae 10-15 part Borneolum Syntheticum 0.1-0.3 part.
2, a kind of method for preparing the described gynaecologic washing lotion of claim 1 is characterized in that, may further comprise the steps:
A filters the Radix Stemonae, Radix Salviae Miltiorrhizae 60-80% alcohol reflux 2 times of described weight portion, merging filtrate, and medicinal residues are standby;
B with the Flos Caryophylli of described weight portion, Fructus Cnidii, Herba Menthae, Pericarpium Zanthoxyli with water extraction volatile oil 1 time, each 2-4 hour, collect volatile oil, standby;
Continue to collect 0.5 times of oil-water mixture of this step medical material amount, medicinal liquid is separated with medicinal residues, obtain medicinal liquid and medicinal residues, standby;
C is with Rhizoma Smilacis Chinensis, Cortex Dictamni, Radix Sophorae Flavescentis, Cortex Phellodendri, Rhizoma Polygoni Cuspidati, Herba Taraxaci, Rhizoma Coptidis, the Fructus Kochiae and the Radix Stemonae, the Radix Salviae Miltiorrhizae decoction dregs of described weight portion, and Flos Caryophylli, Fructus Cnidii, Herba Menthae, water extraction 2-4 time of Pericarpium Zanthoxyli medicinal residues filter, and merging filtrate is abandoned medicinal residues, filtrate for later use;
The medicinal liquid that D makes A, B, C step merges, and when being concentrated into the suitable crude drug in whole 1-1.4g of every 1ml, adds 95% ethanol, makes to contain the alcohol amount and be 60-80%, leaves standstill, and gets supernatant, reclaims ethanol, is concentrated into an amount of concentrated solution, and is standby;
E merges prepared volatile oil among gained concentrated solution, the step B among the step D, adds Borneolum Syntheticum, and mix homogeneously is diluted with water to corresponding requirement again, and the pH scope is 4-6, promptly gets described gynaecologic washing lotion.
According to the preparation method of the described gynaecologic washing lotion of claim 2, it is characterized in that 3, described step e is: prepared volatile oil among gained concentrated solution, the step B among the step D is merged, add Borneolum Syntheticum, and the appropriate amount of auxiliary materials mix homogeneously, being diluted with water to corresponding requirement again, the pH scope is 4-6.
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| CN102133379A (en) * | 2011-03-24 | 2011-07-27 | 柳莉娟 | Traditional Chinese medicine pill for treating gynecopathy |
| CN102178814A (en) * | 2011-04-13 | 2011-09-14 | 王连芝 | Chinese medicinal composition for treating trichomonas vaginitis and preparation method thereof |
| CN102228651A (en) * | 2011-06-23 | 2011-11-02 | 张海 | Traditional Chinese medicine composition for treating gynecologic inflammation, and preparation method thereof |
| CN102526390A (en) * | 2012-03-22 | 2012-07-04 | 常熟市虞山绿茶有限公司 | Chinese medicine preparation for treating gynecological vaginitis |
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| CN102178814A (en) * | 2011-04-13 | 2011-09-14 | 王连芝 | Chinese medicinal composition for treating trichomonas vaginitis and preparation method thereof |
| CN102178814B (en) * | 2011-04-13 | 2012-11-07 | 王连芝 | Chinese medicinal composition for treating trichomonas vaginitis and preparation method thereof |
| CN102228651A (en) * | 2011-06-23 | 2011-11-02 | 张海 | Traditional Chinese medicine composition for treating gynecologic inflammation, and preparation method thereof |
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| CN102526441A (en) * | 2012-03-22 | 2012-07-04 | 常熟市虞山绿茶有限公司 | Traditional Chinese medicine flushing liquor special for gynecological inflammation treatment |
| CN102579654A (en) * | 2012-03-26 | 2012-07-18 | 杨长辉 | Anti-bacteria medicine for protecting and cleaning human body vagina and preparation method thereof |
| CN102743562A (en) * | 2012-06-17 | 2012-10-24 | 任平 | Preparation method of Chinese medicine irrigation solution for treating constipation type trichomonas vaginitis |
| CN102743625A (en) * | 2012-06-17 | 2012-10-24 | 邓梅 | Preparation method of Chinese medicine irrigation solution for treating yellow and turbid urine type trichomonas vaginitis |
| CN102755426B (en) * | 2012-07-10 | 2015-07-15 | 李顺祥 | Chinese medicament for treating gynecological inflammation and preparation method |
| CN102755426A (en) * | 2012-07-10 | 2012-10-31 | 李顺祥 | Chinese medicament for treating gynecological inflammation and preparation method |
| CN102743662A (en) * | 2012-07-18 | 2012-10-24 | 广西中医药大学 | Zhuang medicine preparation for treating gynecological inflammation and preparation method thereof |
| CN102743662B (en) * | 2012-07-18 | 2015-03-11 | 广西中医药大学 | Zhuang medicine preparation for treating gynecological inflammation and preparation method thereof |
| CN103007124B (en) * | 2012-12-28 | 2014-05-28 | 吉林大学公共卫生学院 | Chinese medicine preparation for treating gynecologic inflammation |
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Application publication date: 20090909 |