CN102579822B - Antimicrobial and production method thereof - Google Patents
Antimicrobial and production method thereof Download PDFInfo
- Publication number
- CN102579822B CN102579822B CN201210030896.9A CN201210030896A CN102579822B CN 102579822 B CN102579822 B CN 102579822B CN 201210030896 A CN201210030896 A CN 201210030896A CN 102579822 B CN102579822 B CN 102579822B
- Authority
- CN
- China
- Prior art keywords
- herba
- subsequent use
- radix
- filtrate
- flos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to an antimicrobial, which is characterized by comprising the following raw materials that: cloves, wild chrysanthemum flowers, dark plum, wormwood, swamp mahogany, frutus cnidii, radix salviae miltiorrhizae, purslane, Chinese violet, Chinese ixeris herb, herba commelinae, rhizoma coptidis, bletilla striata, honeysuckle, isatis root and sophora flavescens alkaloids. The invention also relates to a preparation method of the antimicrobial, which comprises steps such as pulverizing of raw materials, proportioning, alcohol extraction and mixing.
Description
Technical field
The present invention relates to antibacterial preparation field, especially, the present invention relates to a kind of Chinese medicine extraction antibacterial.
Background technology
Also have at present some medicaments that play antibacterial effect as JIEERYIN etc., but its subject range is narrow, and medicinal effects is also not exclusively fully up to expectations.
Patent of invention CN1329831 is an early stage disinfectant invention of applicant, and its material composition comprises Flos Caryophylli, Herba Senecionis Scandentis, the Radix Pulsatillae, Herba Chenopodii, Folium Eucalypti Robustae, Fructus Cnidii, Radix Salviae Miltiorrhizae, Semen Hydnocarpi, Herba Portulacae, Herba Violae, Radix Arnebiae (Radix Lithospermi), Foliumet Ramulus Evodiae, Rhizoma Coptidis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Cortex Phellodendri, Flos Lonicerae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis total alkaloids, Radix Isatidis, Cortex Fraxini etc.It can reach good sterilization.But its shortcoming is that in material composition, cold raw material is more, for the patient of the empty cold body constitution of body and be not suitable for life-time service, therefore after often needing medication a period of time, after inactive a period of time, continue again to use, to avoid contingent side effect, in raw material, Herba Chenopodii and Semen Hydnocarpi etc. are the toxic raw materials medicine in Chinese medicine ingredients simultaneously, although this invention does not have the poisoning report that waits side effect, has after all risk, and its preparation method is also comparatively complicated.
Summary of the invention
One object of the present invention is to provide a kind of safety, more remarkable treatment effect, antibacterial applied widely of using.
Antibacterial of the present invention is made up of following raw material: Flos Caryophylli, Flos Chrysanthemi Indici, Fructus Mume, Folium Artemisiae Argyi, Folium Eucalypti Robustae, Fructus Cnidii, Radix Salviae Miltiorrhizae, Herba Portulacae, Herba Violae, Herba Ixeritis chinensis, Herba Commelinae, Rhizoma Coptidis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Isatidis, Radix Sophorae Flavescentis total alkaloids.
Further, the weight proportion of antibacterial raw material of the present invention is: Flos Caryophylli 4-8, Flos Chrysanthemi Indici 3-6, Fructus Mume 3-6, Folium Artemisiae Argyi 6-9, Folium Eucalypti Robustae 4-6, Fructus Cnidii 4-6, Radix Salviae Miltiorrhizae 3-5, Herba Portulacae 6-9, Herba Violae 2-6, Herba Ixeritis chinensis 6-9, Herba Commelinae 4-6, Rhizoma Coptidis 3-6, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7, Flos Lonicerae 3-6, Radix Isatidis 2-6, Radix Sophorae Flavescentis total alkaloids 12-18.
Further, the weight proportion of antibacterial raw material of the present invention is: Flos Caryophylli 6, Flos Chrysanthemi Indici 5, Fructus Mume 4, Folium Artemisiae Argyi 7, Folium Eucalypti Robustae 5, Fructus Cnidii 5, Radix Salviae Miltiorrhizae 4, Herba Portulacae 8, Herba Violae 4, Herba Ixeritis chinensis 8, Herba Commelinae 5, Rhizoma Coptidis 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Flos Lonicerae 5, Radix Isatidis 4, Radix Sophorae Flavescentis total alkaloids 15.
Another object of the present invention is to provide the production method of described antibacterial.Comprise step:
(1) Chinese medicine is pulverized, and selects the clean dry Flos Caryophylli of high-quality, Flos Chrysanthemi Indici, Fructus Mume, Folium Artemisiae Argyi, Folium Eucalypti Robustae, Fructus Cnidii, Radix Salviae Miltiorrhizae, Herba Portulacae, Herba Violae, Herba Ixeritis chinensis, Herba Commelinae, Rhizoma Coptidis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Isatidis is pulverized, and its granularity 10-40 order, packs in container and waits to prepare burden;
(2) batching: the Chinese medicine crushing, according to required ratio, proportioning and weighing;
(3) alcohol extraction: the Chinese herbal medicine preparing is packed into and adds weight of material 4-10 60% ethanol doubly in the steam heated multifunctional extracting pot of chuck simultaneously, heating and refluxing extraction was filtered after 2 hours, obtain filtrate (1) for subsequent use, filtering residue in tank adds 3-4 60% alcohol heating reflux doubly to extract again 2 hours, after filtration, obtain filtrate (2) for subsequent use, 1/2 volume that adds evaporation and concentration tank heating evaporation to be recycled to filtrate (1) for subsequent use and (2) cumulative volume after (1) for subsequent use filtrate and filtrate (2) for subsequent use mix homogeneously is obtained to concentrated solution (3) for subsequent use,
(4) preparation: take concentrated solution (3) for subsequent use and add in material-compound tank and be heated to 40 DEG C, stir and add Radix Sophorae Flavescentis total alkaloids, fully stir 0.5-1 hour, after filtration, stock solution gets product.
Further, in step (4), also can add triclosan solution after adding Radix Sophorae Flavescentis total alkaloids, after stirring, add azone and obtain product.
The invention has the advantages that:
1, this antibacterial, to various commonly encountered diseases substances, comprises antibacterial, fungus, and virus, protozoon, spirillums etc. all have remarkable antibacterial and inhibitory action.Can also treat gynaecopathia to skin, senile and pruritus of vagina itching-relieving action effectively, to skin, mucosa is non-stimulated, without anaphylaxis
The use of 2, having rejected the cold raw materials such as Herba Senecionis Scandentis, the Radix Pulsatillae, Cortex Fraxini, has obtained wider patient's range of application.
The use of 3, having rejected the toxic raw materials such as Herba Chenopodii, Semen Hydnocarpi, has obtained safer range of application
4, use raw material still less, obtained better therapeutic effect.
5, preparation method is more simple.
Brief description of the drawings
The production technological process that accompanying drawing 1 is antibacterial of the present invention.
Detailed description of the invention
Embodiment 1
(1) prepare raw material of Chinese medicine, pulverize, granularity 10 orders, pack in container and wait to prepare burden;
(2) batching: the Chinese medicine crushing according to Flos Caryophylli 4kg, Flos Chrysanthemi Indici 3kg, Fructus Mume 3kg, Folium Artemisiae Argyi 9kg, Folium Eucalypti Robustae 4kg, Fructus Cnidii 4kg, Radix Salviae Miltiorrhizae 3kg, Herba Portulacae 6kg, Herba Violae 2kg, Herba Ixeritis chinensis 9kg, Herba Commelinae 6kg, Rhizoma Coptidis 6kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 5kg, Flos Lonicerae 3kg, Radix Isatidis 2kg carries out weighing and proportioning;
(3) alcohol extraction: the Chinese herbal medicine preparing is packed into 60% ethanol that simultaneously adds 4 times of weight of material in the steam heated multifunctional extracting pot of chuck, heating and refluxing extraction was filtered after 2 hours, obtain filtrate (1) for subsequent use, filtering residue in tank adds 60% alcohol heating reflux of 4 times to extract again 2 hours, after filtration, obtain filtrate (2) for subsequent use, 1/2 volume that adds evaporation and concentration tank heating evaporation to be recycled to filtrate (1) for subsequent use and (2) cumulative volume after (1) for subsequent use filtrate and filtrate (2) for subsequent use mix homogeneously is obtained to concentrated solution (3) for subsequent use;
(4) preparation: take concentrated solution (3) for subsequent use and add in material-compound tank and be heated to 40 DEG C, stir and add Radix Sophorae Flavescentis total alkaloids 12kg, fully stir 0.5 hour, after filtration, stock solution gets product.
Embodiment 2
(1) prepare raw material of Chinese medicine, pulverize, granularity 10 orders, pack in container and wait to prepare burden;
(2) batching: the Chinese medicine crushing, according to Flos Caryophylli 6kg, Flos Chrysanthemi Indici 5kg, Fructus Mume 4kg, Folium Artemisiae Argyi 7kg, Folium Eucalypti Robustae 5kg, Fructus Cnidii 5kg, Radix Salviae Miltiorrhizae 4kg, Herba Portulacae 8kg, Herba Violae 4kg, Herba Ixeritis chinensis 8kg, Herba Commelinae 5kg, Rhizoma Coptidis 5kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 6kg, Flos Lonicerae 5kg, Radix Isatidis 4kg weighs proportioning;
(3) alcohol extraction: the Chinese herbal medicine preparing is packed into 60% ethanol that simultaneously adds 8 times of weight of material in the steam heated multifunctional extracting pot of chuck, heating and refluxing extraction was filtered after 2 hours, obtain filtrate (1) for subsequent use, filtering residue in tank adds 60% alcohol heating reflux of 3 times to extract again 2 hours, after filtration, obtain filtrate (2) for subsequent use, 1/2 volume that adds evaporation and concentration tank heating evaporation to be recycled to filtrate (1) for subsequent use and (2) cumulative volume after (1) for subsequent use filtrate and filtrate (2) for subsequent use mix homogeneously is obtained to concentrated solution (3) for subsequent use;
(4) preparation: take concentrated solution (3) for subsequent use and add in material-compound tank and be heated to 40 DEG C, stir and add Radix Sophorae Flavescentis total alkaloids 15kg, fully stir 1 hour, after filtration, stock solution gets product.
Embodiment 3
(1) prepare raw material of Chinese medicine, pulverize, granularity 30 orders, pack in container and wait to prepare burden;
(2) batching: the Chinese medicine crushing, according to Flos Caryophylli 8kg, Flos Chrysanthemi Indici 6kg, Fructus Mume 6kg, Folium Artemisiae Argyi 6kg, Folium Eucalypti Robustae 6kg, Fructus Cnidii 6kg, Radix Salviae Miltiorrhizae 5kg, Herba Portulacae 9kg, Herba Violae 6kg, Herba Ixeritis chinensis 6kg, Herba Commelinae 4kg, Rhizoma Coptidis 3kg, Pseudobulbus Bletillae (Rhizoma Bletillae) 7kg, Flos Lonicerae 6kg, Radix Isatidis 6kg weighs proportioning;
(3) alcohol extraction: the Chinese herbal medicine preparing is packed into 60% ethanol that simultaneously adds 10 times of weight of material in the steam heated multifunctional extracting pot of chuck, heating and refluxing extraction was filtered after 2 hours, obtain filtrate (1) for subsequent use, filtering residue in tank adds 60% alcohol heating reflux of 3 times to extract again 2 hours, after filtration, obtain filtrate (2) for subsequent use, 1/2 volume that adds evaporation and concentration tank heating evaporation to be recycled to filtrate (1) for subsequent use and (2) cumulative volume after (1) for subsequent use filtrate and filtrate (2) for subsequent use mix homogeneously is obtained to concentrated solution (3) for subsequent use;
(4) preparation: take concentrated solution (3) for subsequent use and add in material-compound tank and be heated to 40 DEG C, stir and add Radix Sophorae Flavescentis total alkaloids 18kg, add triclosan solution 10kg, add azone 5kg after stirring, fully stir 1 hour, after filtration, stock solution gets product.
Embodiment 4
The clinical testing data of antibacterial of the present invention
| Disease name | Number of cases | Cure | Effective | Effectively | Invalid | Cure (%) | Effective percentage (%) |
| Trichomonal vaginitis | 77 | 66 | 6 | 0 | 5 | 85.7 | 93.5 |
| Toadstool property vaginitis | 54 | 42 | 2 | 4 | 6 | 77.8 | 88.9 |
| Nonspecific vaginitis | 11 | 9 | 2 | 0 | 0 | 81.8 | 100 |
| Senile vaginitis | 8 | 7 | 0 | 1 | 0 | 87.5 | 100 |
| Youngest daughter's vulvitis | 4 | 4 | 0 | 0 | 0 | 100 | |
| Pudendal pruritus | 16 | 43 | 1 | 1 | 1 | 81.3 | 93.8 |
| Vulval eczema | 6 | 5 | 1 | 0 | 0 | 83.3 | 100 |
| Gonococcal vaginitis | 5 | 5 | 0 | 0 | 0 | 100 | |
| Vulval condyloma acuminatum | 3 | 2 | 0 | 1 | 0 | 66.7 | 100 |
| Cervicitis | 4 | 4 | 0 | 0 | 0 | 100 | |
| Cervical erosion | 33 | 28 | 1 | 3 | 1 | 84.8 | 97.0 |
| Eczema | 7 | 6 | 0 | 1 | 0 | 85.7 | 100 |
| Neurodermatitis | 3 | 2 | 1 | 0 | 0 | 66.7 | 100 |
| Pus miliaria | 15 | 14 | 1 | 0 | 0 | 98.3 | 100 |
| Pimple Herba Urticae Cannabinae disease | 9 | 2 | 2 | 5 | 0 | 22.2 | 100 |
| Impetigo | 5 | 5 | 0 | 0 | 0 | 100 | |
| Brothers Ti Xian (wart) | 28 | 22 | 5 | 1 | 0 | 78.6 | 100 |
| Young illness skin ulcer | 9 | 6 | 1 | 2 | 0 | 66.7 | 100 |
| Scabies | 2 | 2 | 0 | 0 | 0 | 100 | |
| Add up to | 315 | 257 | 24 | 21 | 13 | 81.6 | 95.9 |
The successful of antibacterial of the present invention is better than the product of existing market, and the preceding antibacterial invention of inventor.
Claims (3)
1. an antibacterial, is characterized in that being made up of the raw material of following weight proportion: Flos Caryophylli 4-8, Flos Chrysanthemi Indici 3-6, Fructus Mume 3-6, Folium Artemisiae Argyi 6-9, Folium Eucalypti Robustae 4-6, Fructus Cnidii 4-6, Radix Salviae Miltiorrhizae 3-5, Herba Portulacae 6-9, Herba Violae 2-6, Herba Ixeritis chinensis 6-9, Herba Commelinae 4-6, Rhizoma Coptidis 3-6, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-7, Flos Lonicerae 3-6, Radix Isatidis 2-6, Radix Sophorae Flavescentis total alkaloids 12-18.
2. a kind of antibacterial according to claim 1, is characterised in that the weight proportion of described raw material is: Flos Caryophylli 6, Flos Chrysanthemi Indici 5, Fructus Mume 4, Folium Artemisiae Argyi 7, Folium Eucalypti Robustae 5, Fructus Cnidii 5, Radix Salviae Miltiorrhizae 4, Herba Portulacae 8, Herba Violae 4, Herba Ixeritis chinensis 8, Herba Commelinae 5, Rhizoma Coptidis 5, the Pseudobulbus Bletillae (Rhizoma Bletillae) 6, Flos Lonicerae 5, Radix Isatidis 4, Radix Sophorae Flavescentis total alkaloids 15.
3. the production method of antibacterial according to claim 1 and 2, comprises step:
(1) Chinese medicine is pulverized, and selects the clean dry Flos Caryophylli of high-quality, Flos Chrysanthemi Indici, Fructus Mume, Folium Artemisiae Argyi, Folium Eucalypti Robustae, Fructus Cnidii, Radix Salviae Miltiorrhizae, Herba Portulacae, Herba Violae, Herba Ixeritis chinensis, Herba Commelinae, Rhizoma Coptidis, the Pseudobulbus Bletillae (Rhizoma Bletillae), Flos Lonicerae, Radix Isatidis is pulverized, and its granularity 10-40 order, packs in container and waits to prepare burden;
(2) batching: the Chinese medicine crushing, according to required ratio, proportioning and weighing;
(3) alcohol extraction: the Chinese herbal medicine preparing is packed into and adds weight of material 4-10 60% ethanol doubly in the steam heated multifunctional extracting pot of chuck simultaneously, heating and refluxing extraction was filtered after 2 hours, obtain filtrate for subsequent use 1, filtering residue in tank adds 3-4 60% alcohol heating reflux doubly to extract again 2 hours, after filtration, obtain filtrate for subsequent use 2, by for subsequent use filtrate 1 and filtrate 2 mix homogeneously for subsequent use after add evaporation and concentration tank heating evaporation to be recycled to filtrate for subsequent use 1 and 2 cumulative volumes 1/2 volume obtain concentrated solution for subsequent use 3;
(4) preparation: take concentrated solution for subsequent use 3 and add in material-compound tank and be heated to 40 DEG C, stir and add Radix Sophorae Flavescentis total alkaloids, fully stir 0.5-1 hour, after filtration, stock solution gets product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210030896.9A CN102579822B (en) | 2012-02-04 | 2012-02-04 | Antimicrobial and production method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210030896.9A CN102579822B (en) | 2012-02-04 | 2012-02-04 | Antimicrobial and production method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102579822A CN102579822A (en) | 2012-07-18 |
| CN102579822B true CN102579822B (en) | 2014-06-04 |
Family
ID=46469423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210030896.9A Expired - Fee Related CN102579822B (en) | 2012-02-04 | 2012-02-04 | Antimicrobial and production method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102579822B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104398638A (en) * | 2014-09-23 | 2015-03-11 | 汪书林 | Bacteriostatic bag containing golden cypress and clove, and preparation method and application method thereof |
| CN105254926A (en) * | 2015-10-19 | 2016-01-20 | 界首市佳宝包装材料有限公司 | Edible lollipop packaging film |
| CN105254927A (en) * | 2015-10-19 | 2016-01-20 | 界首市佳宝包装材料有限公司 | Safe and environment-friendly packaging film for disinfected tableware |
| CN105401408A (en) * | 2015-12-18 | 2016-03-16 | 苏州富美纺织科技有限公司 | Preparation method for fabrics antibacterial finishing liquid |
| CN106538621A (en) * | 2016-09-29 | 2017-03-29 | 四川三和医用材料有限公司 | A kind of medical glovess disinfectant solution containing Folium Mori extract |
| CN106719945A (en) * | 2016-11-23 | 2017-05-31 | 广东食品药品职业学院 | A kind of anti-controlling agent of Citrus Huanglongbing pathogen Chinese medicine and preparation method thereof |
| CN106580791B (en) * | 2016-12-23 | 2020-06-09 | 广州睿森生物科技有限公司 | Antibacterial composition and private care product |
| CN107252406A (en) * | 2017-05-27 | 2017-10-17 | 霍山宝信园石斛开发有限公司 | A kind of Essence containing Herba Dendrobii extract and preparation method thereof |
| CN113100256A (en) * | 2021-04-14 | 2021-07-13 | 重庆佳钰铭文化旅游有限责任公司 | Traditional Chinese medicine antibacterial liquid and preparation method thereof |
| CN115708785B (en) * | 2022-11-16 | 2024-05-28 | 遵义医药高等专科学校 | Herbal washing-free gel and preparation process thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329831A (en) * | 2000-06-17 | 2002-01-09 | 内蒙古苦参生化集团有限责任公司 | Disinfectant and its preparing process |
| CN101518600A (en) * | 2009-03-30 | 2009-09-02 | 李燕 | Chinese medicinal composition for treating bacterial or fungal dermatosis and preparation method thereof |
| CN101804166A (en) * | 2010-05-05 | 2010-08-18 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
-
2012
- 2012-02-04 CN CN201210030896.9A patent/CN102579822B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1329831A (en) * | 2000-06-17 | 2002-01-09 | 内蒙古苦参生化集团有限责任公司 | Disinfectant and its preparing process |
| CN101518600A (en) * | 2009-03-30 | 2009-09-02 | 李燕 | Chinese medicinal composition for treating bacterial or fungal dermatosis and preparation method thereof |
| CN101804166A (en) * | 2010-05-05 | 2010-08-18 | 余静 | Traditional Chinese medicine composition for treating dermatitis and eczema of infants |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102579822A (en) | 2012-07-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102579822B (en) | Antimicrobial and production method thereof | |
| CN103705878B (en) | One treats migraine Chinese medicine preparation | |
| CN103845417A (en) | Chinese herbal granule used for relieving pain caused by sudden sprain in lumbar region | |
| CN102091268A (en) | Medicament for treating allergic rhinitis and preparation method thereof | |
| CN101417033B (en) | Traditional Chinese medicine for treating insomnia | |
| CN102038751A (en) | Traditional Chinese medicine formulation for treating infantile diarrhea | |
| CN102755416A (en) | Chinese medicine composition for treating dermatophytosis and preparation method of Chinese medicine composition | |
| CN102293913A (en) | Tea for treating cold | |
| CN102389498A (en) | Traditional Chinese medicine for curing diabetic diarrhea | |
| CN102166323A (en) | Medicine for curing burn and preparation method thereof | |
| CN102000203A (en) | A traditional Chinese medicine for dispelling wind and eliminating dampness, promoting blood circulation and removing blood stasis | |
| CN102309712A (en) | Traditional Chinese medicine decoction for treating malaria | |
| CN104547976A (en) | Traditional Chinese medicinal composition for treating esophagus cancer | |
| CN102641453A (en) | Medicine for treating diabetes mellitus and preparation method thereof | |
| CN102670809A (en) | Drug for curing pharyngitis and preparing method thereof | |
| CN102631459A (en) | Traditional Chinese medicine for treating chronic prostatitis | |
| CN102389531A (en) | Traditional Chinese medicine for curing chronic prostatitis | |
| CN102038904A (en) | Chinese prescription for treating leucoderma | |
| CN101444564A (en) | Liquid medicine for treating hemorrhoids | |
| CN103816473A (en) | Traditional Chinese medicine for treating febrile diseases and preparation method thereof | |
| CN103550743A (en) | Natural medicinal plant oral jelly and preparation method thereof | |
| CN104548006A (en) | Traditional Chinese medicine mixture for treating rhinitis | |
| CN104435597A (en) | Medicine for treating habitual constipation and preparation method thereof | |
| CN103893341A (en) | Washing solution for treating women's colpitis | |
| CN102847052A (en) | A Chinese medicinal formulation for treating irregular menstruation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140604 Termination date: 20160204 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |