CN101500577A

CN101500577A - Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile

Info

Publication number: CN101500577A
Application number: CNA2006800531536A
Authority: CN
Inventors: M·R·希尔
Original assignee: Tika Lakemedel AB
Current assignee: Tika Lakemedel AB
Priority date: 2005-12-20
Filing date: 2006-12-19
Publication date: 2009-08-05

Abstract

The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies.

Description

Carrying method and system with the corticosteroid that strengthens pharmacokinetic properties

Invention field

The present invention relates to be used to carry the method and system of corticosteroid, this method and system comprises: sucked aqueous mixture and (2) that (1) comprises corticosteroid and solubility enhancing agent can suck nebulizer, wherein, carry the aqueous mixture that comprises corticosteroid to cause the lung deposition that can suck treatment enhanced PK (pharmacokinetic) profile (pharmacokinetic profile) and/or increase by described nebulizer than routine.

Background of invention

The corticosteroid that sucks is an essence for the long-term treatment of persistence asthma, and is recommended to be used for the treatment of the child who is diagnosed as asthma by national guidelines.The effect of the corticosteroid that a large amount of clinical trial support sucks and to child's relative safety.In addition, the early intervention that it is believed that corticosteroid can play a crucial role aspect the permanent injury of lung and can change the chronic of disease and carrying out property character reducing.

(employed among the present invention " lung " is meant left lung or right lung owing to be delivered directly to action site-lung; Perhaps be meant left lung and right lung), so, use the corticosteroid treatment asthma that sucks to have significant beneficial effect.The purpose of the corticosteroid treatment that sucks is thereby that the local messenger drug of carrying of corticosteroid is worked at once at action site.The corticosteroid of known suction is absorbed well from pulmonary.In fact, can think that basically all medicines that can arrive the pulmonary acceptor site will be absorbed.Yet also known present method and formulation is swallowed and can be by buccal absorption the corticosteroid dosage of more most suction.Therefore, because the specific method or the system that use, some corticosteroid more may be deposited in oral cavity and the throat rather than lung, and may cause detrimental effects.The part of the corticosteroid dosage of the suction of carrying for the oral cavity, bioavailability depend on that gastrointestinal absorbs and the degree of first pass metabolism (first pass metabolism) in liver.Because the oral cavity part that corticosteroid medication is carried does not produce any useful therapeutic effect and the risk of increase systemic side effects, so the oral cavity bioavailability of the corticosteroid that expectation sucks is low relatively.Therefore, for the corticosteroid that sucks, high pulmonary's availability is more important than high oral cavity availability, because lung is a target organ.

Like this, but provide the method for corticosteroid or system for having bigger potential in pulmonary's positive effect of performance with high pulmonary's availability.Provide the ideal system of the corticosteroid of suction can produce minimum oral cavity conveying and reduce administration time, thereby reduce the probability of systemic side effects.

Yet, regrettably, often cause corticosteroid to be deposited on position outside the respiratory tract by suck carrying corticosteroid, as oral cavity, throat and esophagus.Usually, the particle size of corticosteroid is more little, and granule keeps long more and medicine of time of suspending can be transferred deeply more along respiratory tract in air.Corticosteroid is carried by the suction that utilizes nebulizer, metered dose inhaler or Diskus.The major advantage that nebulizer is compared other method of corticosteroid pulmonary delivery is that nebulizer can more effectively be carried the more medicine of high dose than other method.Yet, be that cost improves, portability reduces, the inconvenience of longer time of needs in the time of need preparing medicine and administration in advance for the major concern of nebulizer.Therefore, need a kind of method of improving drug conveying, for example carry corticosteroid by atomizing.

Granular size and preparation all influence the effect of the corticosteroid of suction.The preparation of medicine has remarkable influence for medicine to the conveying of lung, thereby influences the effect of medicine.In addition, it is believed that be aerosol excipient and the particulate size of conveying for medicine to the most important consideration of the conveying of lung.

The particulate suction of known drug is imperfect with respect to dissolved drug.(Bronchial Asthma, 2nd Ed. (Ed.E.B.Weis etc., Little Brown ﹠amp such as Brain; Co. (1985), pp.594-603) report is deposited on moving to pharynx by cilium than insoluble granule on the mucous layer that covers lung airway and nasal passage.These granules comprise be deposited in the upper respiratory tract than large medicament particles.Mucus, cell and chip from nasal cavity and lung converge and mix with saliva pharyngeal, enter gastrointestinal tract then when swallowing.It is reported, by this mechanism, be that a few minutes were by several hours with granule from the half-life that lung is removed.Therefore, almost not free making dissolves slowly that medicine comprises that corticosteroid such as budesonide dissolve.On the contrary, be deposited on the position of not containing cilium such as the granule of alveolar, its time of staying is longer.Owing to be difficult to produce very short grained corticosteroid to deposit to darker pulmonary, therefore, a lot of suspensions that suck may be deposited on the top of respiratory tract to the middle part.Yet it is more much easier than producing droplet from solid suspension to produce droplet from solution.

Especially use budesonide (R, S)-11 β, 16 α, 17,21-four hydroxyls are pregnant-1,4-diene-3,20-diketone ring 16,17-acetal and butyraldehyde (C ₂₅H ₃₄O ₆, molecular weight: 430.5) treatment bronchus obstacle.The racemate that budesonide is made up of the mixture of two kinds of diastereomer 22R and 22S, and provide at commercial mixture with two kinds of isomers (22R and 22S).It plays a kind of antiphlogistic corticoid, shows effective glucocorticoid activity.Give budesonide and be that treatment asthma is kept in expression and as child's prophylactic treatment.

Because its lipotropy, budesonide and other lipophilic corticosteroid are water insoluble in fact but be soluble in alcohol.Can be by using the active substance of solubilizing agent such as organic water-soluble alcohol dissolving q.s.Yet in this way the solution of Huo Deing has limited stability usually for medicinal usage, because a large amount of active substances may decompose at short notice.

(Wilmington is DE) with trade mark by AstraZeneca LP for the commercial formulation of budesonide EC, Pulmicort

,

Aqua,

Form of nasal inhalers and

Turbuhaler and their adopted name are sold.Pulmicort

Be a kind of aseptic aqueous suspension of micropowder budesonide, by utilizing especially compressed air-driven blast atomizer inhalation of nebulizer.

Form of nasal inhalers is a kind of dosing pressurized aerosol devices that contains the micropowder budesonide suspension that is in the propellant mixture.

Aqua is a kind of scentless dosing manual pump spray agent that contains the suspension of the micropowder budesonide that is in the water-bearing media.In addition, the suspension formulation of budesonide tends to form thick floccule body fast when disperseing and disperse again, and this may influence the dosage repeatability nocuously.Budesonide also tends to deposit on the wall of a container from suspension.

Therefore, need be used for carrying the system and method for the non-suspension formulations that contains budesonide by atomizing.Yet, even in view of this needs, Pulmicort

Suspension is that present unique approved use budesonide is by sucking the therapy for the treatment of infantile asthma.In addition, compositions, the method and system of corticosteroid that equally need be except that budesonide.Therefore, provide a kind of and have that to suck the treatment field than the sedimentary method of lung of enhanced PK (pharmacokinetic) profile that is transferred corticosteroid of the PK (pharmacokinetic) profile of the suspension unit dose formulations that contains corticosteroid and/or increase or system for corticosteroid will be important progress.

Summary of the invention

In certain embodiments, the invention provides a kind of method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises: a kind of moisture suction mixture that comprises corticosteroid and solubility enhancing agent (a) is provided; (b) carry described moisture suction mixture with the suction nebulizer, wherein, described corticosteroid is gone up the pharmaceutically active agents that does not contain except that single corticosteroid substantially with the nominal dosed administration and the wherein said suction mixture that are less than about 125 μ g/ dosage.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, the volume of wherein said moisture suction mixture is about 0.5mL, about 1.0mL, about 1.5mL, about 2.0mL, about 2.5mL, about 3.0mL or about 3.5mL.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

In the embodiment that also has, described bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In other embodiment that also has, the time of delivery of described method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

In other embodiment that also has, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, the administration of wherein said suction mixture was no more than once in one day.In other embodiments, the administration of described suction mixture is for once a day.In other embodiment that also has, the administration of described suction mixture was no more than twice in one day.In other embodiment that still also has, the administration of described suction mixture is one day twice.In other embodiment that also has, the administration at night of described suction mixture.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said suction mixture also comprises the second kind of therapeutic agent that is selected from beta 2-adrenergic receptor agonist, dopamine (D2) receptor stimulating agent, prophylactic treatment agent and anticholinergic.

In other embodiment that also has, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said solubility enhancing agent comprises SBE7-β-CD.In other embodiments, described solubility enhancing agent comprises about 2%, about 5%, about 7% or the SBE-β 7-CD of about 10%w/v.

In other embodiment that also has, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said nominal dosage is about 60 μ g/ dosage.In other embodiments, described nominal dosage is about 40 μ g/ dosage.

In other embodiments, the invention provides a kind of method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises: a kind of corticosteroid of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising (a) is provided; (b) carry described moisture suction mixture with the suction nebulizer, thus, the PK (pharmacokinetic) profile (pharmacokinetic profile) of sucked suspension of nominal dosage corticosteroid is compared with comprising of administration under the same conditions, described method provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of nominal dosage corticosteroid of twice to go up the pharmaceutically active agents that does not contain except that described corticosteroid substantially.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, the nominal dosage of corticosteroid is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension in the wherein said moisture suction mixture.

In other embodiment that also has, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises corticosteroid _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the corticosteroid name dosed administration that can suck suspension.In certain embodiments, the nominal dosage of described moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.In some other embodiment, the nominal dosage of described moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein the local bioavailability of the corticosteroid of the described moisture suction mixture of being carried by described suction nebulizer is greater than the local bioavailability by the corticosteroid that sucks the sucked suspension that nebulizer carries.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, the time of delivery of wherein said method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.In other embodiments, all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In one embodiment, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, the corticosteroid of wherein said moisture suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.In another embodiment, the corticosteroid of described moisture suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

In other embodiments, the invention provides the method for a kind of treatment or prevention bronchus constriction obstacle, wherein said solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the nominal dosage of described moisture suction mixture is about 1:2-1:5 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, the invention provides a kind of intake system that is used for the treatment of or prevents bronchus constriction obstacle, this system comprises: (a) comprise the corticosteroid of nominal dosage and the moisture suction mixture of solubility enhancing agent; (b) be used to carry the suction nebulizer of described moisture suction mixture, when giving the corticosteroid of described patient's name dosage, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage corticosteroid is compared with comprising of administration under the same conditions, described system provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of nominal dosage corticosteroid of twice to go up the pharmaceutically active agents that does not contain except that single corticosteroid substantially.

In other embodiments, the invention provides a kind of intake system, the nominal dosage of corticosteroid is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension in the wherein said moisture suction mixture.

In other embodiment that also has, the invention provides a kind of intake system, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises corticosteroid _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the corticosteroid name dosed administration that can suck suspension.

In other embodiment that also has, the invention provides a kind of intake system, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.In other embodiments, the nominal dosage of described moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, the invention provides a kind of intake system, wherein said nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

In other embodiments, the invention provides a kind of intake system, wherein said suction mixture also comprises the second kind of therapeutic agent that is selected from beta 2-adrenergic receptor agonist, dopamine (D2) receptor stimulating agent, prophylactic treatment agent and anticholinergic.

In other embodiments, the invention provides a kind of intake system, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In one embodiment, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides a kind of intake system, the corticosteroid of wherein said moisture suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.In other embodiments, the corticosteroid of described moisture suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

In other embodiments, the invention provides a kind of method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises: a kind of moisture suction mixture that comprises budesonide and solubility enhancing agent (a) is provided; (b) carry described moisture suction mixture with the suction nebulizer, wherein, described budesonide is gone up the pharmaceutically active agents that does not contain except that budesonide substantially with the nominal dosed administration and the wherein said suction mixture that are less than about 250 μ g/ dosage.

In other embodiments, the invention provides a kind of method, the volume of wherein said moisture suction mixture is about 0.5mL, about 1.0mL, about 1.5mL, about 2.0mL, about 2.5mL, about 3.0mL or about 3.5mL.

In other embodiments, the invention provides a kind of method, wherein said nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

In other embodiments, the invention provides a kind of method, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In other embodiments, the invention provides a kind of method, the time of delivery of wherein said method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.In other embodiment that also has, all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

In other embodiments, the invention provides a kind of method, the administration of wherein said suction mixture was no more than once in one day.In other embodiments, the administration of described suction mixture is for once a day.In other embodiment that also has, the administration of described suction mixture was no more than twice in one day.In other embodiment that also has, the administration of described suction mixture is one day twice.In other embodiment that still also has, the administration at night of described suction mixture.

In other embodiments, the invention provides a kind of method, wherein said suction mixture also comprises the second kind of therapeutic agent that is selected from beta 2-adrenergic receptor agonist, dopamine (D2) receptor stimulating agent, prophylactic treatment agent and anticholinergic.

In other embodiment that also has, the invention provides a kind of method, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In one embodiment, described solubility enhancing agent comprises SBE7-β-CD.In another embodiment, described solubility enhancing agent comprises about 2%, about 5%, about 7% or SBE7-β-CD of about 10%w/v.

In other embodiments, the invention provides a kind of method, wherein said nominal dosage is less than about 250 μ g/ dosage.In another embodiment, described nominal dosage is about 240 μ g/ dosage.In another embodiment, described nominal dosage is about 120 μ g/ dosage.In another embodiment, described nominal dosage is about 60 μ g/ dosage.In another embodiment, described nominal dosage is about 40 μ g/ dosage.

In other embodiments, the invention provides a kind of method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises: a kind of budesonide of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising (a) is provided; (b) carry described moisture suction mixture with the suction nebulizer, thus, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage budesonide is compared with comprising of administration under the same conditions, described method provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of nominal dosage budesonide of twice to go up the pharmaceutically active agents that does not contain except that budesonide substantially.

In other embodiments, the invention provides a kind of method, the nominal dosage of budesonide is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of budesonide in the suspension in the wherein said moisture suction mixture.

In other embodiments, the invention provides a kind of method, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Greatly, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises budesonide _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the budesonide name dosed administration that can suck suspension.

In other embodiments, the invention provides a kind of method, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.In other embodiments, the nominal dosage of described moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, described nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprises the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contains the nebulizer of hydroecium.

In other embodiments, the invention provides a kind of method, wherein the local bioavailability of the budesonide of the described moisture suction mixture of being carried by described suction nebulizer is greater than the local bioavailability by the budesonide that sucks the sucked suspension that nebulizer carries.

In other embodiments, described bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In other embodiments, the time of delivery of described method about 5 for being less than, be less than about 4, be less than about 3, be less than about 2 or be less than about 1.5 minutes.In other embodiment that also has, all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

In other embodiments, described suction mixture also comprises the second kind of therapeutic agent that is selected from beta 2-adrenergic receptor agonist, dopamine (D2) receptor stimulating agent, prophylactic treatment agent and anticholinergic.

In other embodiments, described solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In other embodiments, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides a kind of method, the budesonide of wherein said moisture suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.In other embodiments, the budesonide of described moisture suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.In other embodiment that also has, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides a kind of method, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:4 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, the invention provides a kind of intake system that is used at patient's treatment that needs are arranged or prevention bronchus constriction obstacle, this system comprises: (a) comprise the budesonide of nominal dosage and the moisture suction mixture of solubility enhancing agent; (b) be used to carry the suction nebulizer of described moisture suction mixture, when giving the budesonide of described patient's name dosage, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage budesonide is compared with comprising of administration under the same conditions, described system provides the enhanced PK (pharmacokinetic) profile that comprises the moisture suction mixture of nominal dosage budesonide of twice at least, substantially go up the pharmaceutically active agents that does not contain except that described corticosteroid with wherein said suction mixture, described suction mixture is gone up the pharmaceutically active agents that does not contain except that budesonide substantially.

In other embodiments, the invention provides a kind of intake system, the nominal dosage of budesonide is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of budesonide in the suspension in the wherein said moisture suction mixture.

In other embodiment that also has, the invention provides a kind of intake system, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises budesonide _MaximumThe T of described moisture suction mixture _GreatlyAnd wherein said moisture suction mixture is to be lower than the budesonide name dosed administration that can suck suspension.

In other embodiments, the invention provides a kind of intake system, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.In other embodiments, the nominal dosage of described moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

In other embodiments, the invention provides a kind of intake system, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In other embodiments, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides a kind of intake system, the budesonide of wherein said suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.In other embodiment that also has, the budesonide of described suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.In other embodiment that still also has, described solubility enhancing agent comprises SBE7-β-CD.

In other embodiments, the invention provides a kind of intake system, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:5 with the described ratio that sucks the nominal dosage of suspension.

The accompanying drawing summary

But Fig. 1 represents to contain the lung deposition and the oropharyngeal deposition percentage ratio of the composition for inhalation of budesonide.

Fig. 2 represents from the total lung deposition of the budesonide of scitiphotograph data.

Fig. 3 represents to utilize the percent of respirable part (RF, granular size is less than 5 μ m) of diverse ways (laser diffraction 20L/min, laser diffraction 28.3L/min and stepwise collision (cascade impaction)) mensuration.

Fig. 4 has summarized mean plasma concentration behind single dose budesonide administration A-E.Administration A is with improveing

The 60 μ g that the eFlow nebulizer is carried suck solution with the budesonide+SBE7-β-CD of 99mTc-DTPA labelling.Administration B is with improveing

The 120 μ g that the eFlow nebulizer is carried suck solution with the budesonide+SBE7-β-CD of 99mTc-DTPA labelling.Administration C is with improveing Budesonide+SBE7-β-the CD with the 99mTc-DTPA labelling of the 240 μ g that the eFlow nebulizer is carried sucks solution.Administration D uses

The 500 μ g budesonide suspension (Pulmicort that LC Plus blast atomizer is carried

Administration E uses

The 1000 μ g budesonide suspension (Pulmicort that LC Plus blast atomizer is carried

Fig. 5 has summarized in every day and has given budesonide twice, continues mean plasma concentration after 7 days.Treatment A (Δ-) uses

The 60 μ g that the eFlow nebulizer is carried

Budesonide Inhalation Solution (CBIS) sucks solution.Treatment B (zero-) uses

The 120 μ g CBIS that the eFlow nebulizer is carried suck solution.Treatment C (-) uses

The 250 μ g budesonide suspension (Pulmicort that LC Plus blast atomizer is carried

Treatment D (◇-) uses The 500 μ g budesonide suspension (Pulmicort that LC Plus blast atomizer is carried

Detailed Description Of The Invention

But will describe now the specific embodiments of inhalation group compound disclosed by the invention, system and method in detail. The embodiment Zai the following examples part Zhong explanation of embodiment.

Unless otherwise defined, all scientific and technical terminologies used herein have Yu the technical staff of technical field that the present invention belongs to described herein the identical implication usually understood. It is reference that all Zhuan profits that this paper is mentioned and publication Yin enter Zuo of the present invention.

Some definition

Term used in the present invention " contains ", " comprising ", " as " and " for example " have open infinite Yi Yi.

Term " Yue " the Yu term " approximately " that uses is synonym. Zheng such as one of ordinary skill in the art understand, the concrete boundary line of " Yue " will depend on that the Zu of described Zu of compound divides or other parameter. For instance, about certain Zhi, treat the Yao agent amount of You effect and use term " Yue " to represent that this Zhi exceeds described Zhi a little, that is, the 0.1%-10% that adds deduct, this dosage also are You effect and safety.

" administration under the identical condition of Zai " used as Zhong of the present invention or " Zai identical condition under " refer to that two kinds or more of Yong Yu carry method and/or the system of corticosteroids, wherein, described method and/or system have Yi Zhong or multiple Yong Yu and give the same terms of corticosteroid. The condition of administration can Xuan Zi, but be not limited to, the number of the corticosteroid that gives, the transport way of corticosteroid, administration time, the nominal dosage that gives the experimenter, dosage, the volume of dosage and Yong Yu carry the type of the atomizer of corticosteroid, the perhaps any combination of the condition of above-mentioned Yong Yu administration. It is identical that a little embodiment Zhong of Zai Yi, " Zai identical condition under " can Yi be Zhied the corticosteroid that is given. Other embodiment of Zai Zhong, " Zai identical condition under " can Yi Zhi that to carry the approach of corticosteroid be identical. It is identical that other embodiment Zhong that Zai also has, " Zai identical condition under " Yi are Zhied time of the corticosteroid that gives the experimenter. It is identical that other embodiment Zhong that Zai still has, " Zai identical condition under " Yi are Zhied the nominal dosage of the corticosteroid that gives the experimenter. It is identical that other embodiment Zhong that Zai still also has, " Zai identical condition under " Yi are Zhied the number of dosage. It is identical that other embodiment of Zai Zhong, " Zai identical condition under " can Yi be Zhied the time that gives corticosteroid, but the nominal dosage of corticosteroid is different. It is identical that other embodiment Zhong that Zai still has, " Zai identical condition under " can Yi be Zhied the corticosteroid that gives, but the nominal dosage of corticosteroid is different. It is identical that other embodiment Zhong that Zai still also has, " Zai identical condition under " can Yi be Zhied the corticosteroid that gives, but the nominal dosage of corticosteroid and Yong Yu carry the type of the atomizer of corticosteroid, is different. Other embodiment Zhong that Zai still also has, " Zai identical condition under " can Yi be Zhied the nominal dosage of corticosteroid is identical, but gives the asynchronism(-nization) of corticosteroid. It is identical that other embodiment of Zai Zhong, " Zai identical condition under " can Yi be Zhied the nominal dosage of corticosteroid, but Yong Yu carries type and the time of delivery of the atomizer of corticosteroid, is different. It is identical that other embodiment Zhong that Zai still has, " Zai identical condition under " can Yi be Zhied the corticosteroid that gives, but nominal dosage, Yong Yu to carry type and the administration time of the atomizer of corticosteroid be different.

" bioavilability " refers to that the common Xun that is transported to studied animals or humans encircles the corticosteroid of Zhong such as the percetage by weight of budesonide. Exposed amount (the AUC of Zong during Yao thing intravenous administration_(0-∞)) be generally defined as 100% bioavilability (F%).

" PC " refers to the concentration of plasma fraction Zhong of the Xue Ye of corticosteroid such as budesonide Zai experimenter or patient colony. Ying is when understanding, the difference of the PC You Yu metabolism aspect of corticosteroid such as budesonide and/or from other the possible interaction of therapeutic agent and significantly different between Zhi may Zai experimenter. According to an aspect of the present invention, the PC of corticosteroid such as budesonide may be different Yin experimenter's difference. Equally, such as the largest PC (C_{The largest}) or reach the time (T of the large PC of Zui_{The largest}) or be carved into from zero the time Zui after can measure the TG-AUC (AUC of concentration time_{After Zui}) or the PC time graph under Zong area (AUC_(0-∞)) numerical value may be different Yin experimenter's difference. This changeability of You Yu, Zu becomes the essential amount of corticosteroid such as budesonide " Zhi treats effective dose " different Yin experimenter's difference possibility.

" Zhi tracheae constriction Zhang hinders " that Zhong of the present invention uses refers on the Zai body to show any disease or the illness that the Zhi tracheae shrinks or narrows down. The example that Zhi tracheae constriction Zhang hinders includes but not limited to asthma, asthma in children, bronchial astehma, allergic asthma, intrinsic asthma, COPD (COPD), chronic bronchitis and pulmonary emphysema.

" routine can suck corticosteroid Zhi and treat " or " the sucked suspension that contains corticosteroid " that Zhong of the present invention uses refer to use the agent processed of obtainable corticosteroid based on suspension, and be for example, commercially availableRespules (budesonide suspension) Yu atomizer, the Zu of You Xuan blast atomizer such as Pari LC Jet Plus atomizer closes, Yi comes Zhi treatment asthma and/or COPD (COPD) or other Zhi tracheae constriction Zhang to hinder for Zhi treatment You effect dosage or those routine doses well known by persons skilled in the art of given experimenter, Zhong group or colony, described routine dose well known by persons skilled in the art is for for example, for the agent processed of above-mentioned business

Respules, dosage are 500-2000 μ g/ days Yue. You it be, the budesonide suspension comparator of You Xuan isRespules, it is commercially available budesonide suspension, this budesonide suspension Zai UD ampoule Zhong contains Xuan and floats over the 250 μ g budesonides of the moisture volume Zhong of 2ml, and perhaps Zai UD ampoule Zhong contains Xuan and floats over the 500 μ g budesonides of the moisture volume Zhong of 2ml. The agent processed of the corticosteroid based on suspension in addition comprises beclomethasone dipropionate

And fluticasone propionate

Wherein, pass through to suck the atomizer administration based on the corticosteroid of suspension agent Yi processed Zhi treatment You effect dosage or those routine doses well known by persons skilled in the art.

" absorption of Yao thing " or " absorption " typically refer to the Yao thing and carry site to hinder the moving process of Yi in intravasation or Zuo Yong site by Zhang from the Yao thing, and for example, the Yao thing is absorbed in the pulmonary capillary bed Zhong of alveolar.

" equating " or " suitable " that the present invention uses refer to that two kinds or more of parameters or numerical value have identical in fact Zhi. Zheng such as the skilled artisan will recognize, " equating " or the exact boundary of " suitable " will depend on analyzed specific parameter or numerical value. For instance, term " equal " or " suitable " that the present invention uses comprise the numerical value that exceeds a little described numerical value, and 0.1%-25% namely adds deduct. For example, Zai context Zhong of the present invention, numerical value is the C of 578.2 (pg/ml)_{The largest}Yu numerical value be the C of 556.74pg/ml_{The largest}Suitable. Similarly, another example of Zai Zhong, numerical value is the C of 1195.3 (pg/ml)_{The largest}Yu numerical value be the C of 1114.83pg/ml_{The largest}Suitable.

" the suction atomizer " that Zhong of the present invention uses refers to that the Zhuan such as Yao thing, Zu compound, agent processed, suspension and mixture are become thin vaporific Yi is transported to the Yi device of lung.

" aqueous mixture of suction ", " the moisture suction mixture " or " but inhalation group compound " that Zhong of the present invention uses typically refers to Yong Yu and sucks any moisture (comprising partially aqueous) dosage form of the active agent of carrying non-suspension. But the example of suitable aqueous mixture or inhalation group compound includes but not limited to solution, dispersion, nanometer dispersion, nano particle suspension, emulsion, colloidal solution, micella or mixed micelle Ye body and liposome Ye body. The aqueous mixture of the suction that other is suitable also comprises the suspension that has added the strong agent of solubility Zeng and had the solubility that Zeng adds Zhi the initial suspension of small part.

The a little embodiment Zhong of Zai Yi of the present invention, " aqueous mixture of suction ", " moisture suction mixture " or " but inhalation group compound " do not comprise nanometer dispersion and/or nanometer suspension. Other embodiment of Zai Zhong, " aqueous mixture of suction ", " moisture suction mixture " or " but inhalation group compound " do not comprise micella or mixed micelle Ye body or liposome Ye body. Other embodiment Zhong that Zai also has, " aqueous mixture of suction ", " moisture suction mixture " or " but inhalation group compound " do not comprise nanometer dispersion and/or nanometer suspension, micella or mixed micelle Ye body or liposome Ye body. Other embodiment of Zai Zhong, " but inhalation group compound " includes but not limited to solution, emulsion and colloidal solution. Zai Yi Zhong embodiment Zhong, but the inhalation group compound is the solution that contains corticosteroid such as budesonide and the strong agent of solubility Zeng. Zai another embodiment Zhong, but the inhalation group compound is the emulsion that contains corticosteroid such as budesonide and the strong agent of solubility Zeng.

When " local bioavilability " refers to that Zai gives the patient by specific transport way with the Yao thing, the part of the available Yao thing of the Yao of the described Yao thing of Zai avtive spot of science Zong dosage. Local bioavilability becomes contrast Yu system bioavilability Xing, and the system bioavilability is the part that the Yao thing that gives arrives the Zong dosage that patient's system Xun encircles. Illustrate by limiting examples, the local bioavilability of the Yao thing of carrying by suction refers to Zai when sucking the transport way administration, is transported to the part of Zong dosage of Yao thing of the suction of lung

" the nominal dosage " that Zhong of the present invention uses but refer to that but pharmaceutically active reagent such as corticosteroid Zai comprise the Zong amount that Zai inhalant dosage form Zhong exists before the inhalant dosage form administration of this pharmaceutically active reagent. Yin this, illustrate by limiting examples, the moisture suction mixture that contains nominal dosage and be the budesonide of 120 μ g/ dosage refers to that Zai gives this moisture suction mixture before Zhi the patient with moisture suction mixture and contains the budesonide of about 120 μ g. Equally, the UD ampoule that contains the sucked suspension of the corticosteroid of 1000 μ g such as budesonide, if all the elements thing of described UD ampoule is put into the transferring instrument device such as atomizer gives the patient, so, front this UD ampoule Ying of Zai administration is when having as used in the present invention the Yue nominal dosage of 1000 μ g/ dosage.

" pharmacokinetics " refer to reflect place, Zuo Yong site drug concentration reach and keep Yin element.

Refer to Zhong " the pharmacokinetics characteristic that Zeng is strong " a little embodiments of Zai Yi that Zhong of the present invention uses compare (reference preparation) Yu another kind of pharmaceutical preparation, the Zuo Yong site of this Yao thing of Yi Zhong pharmaceutical preparation (test formulation) Zai shows absorption that Zeng adds or the pharmacokinetics characteristic of distribution. Other embodiment of Zai Zhong, when providing, the Zuo Yong site that gives Zai Yao thing of the moisture suction mixture of Yi Zhong can suck Yu Yi Zhong that suspension is compared suitable absorption or while distributing, the pharmacokinetics characteristic that is enhanced, wherein, described moisture suction mixture be Yi lower than the described nominal dosed administration that sucks suspension (for example, test formulation Yu with reference to product in the name of dosage be that the suitable absorption of 1:2 is the two strong pharmacokinetics characteristics of multiplication; Test formulation Yu with reference to product in the name of dosage be that the suitable absorption of 1:3 is the three strong pharmacokinetics characteristics of multiplication; Test formulation Yu with reference to product in the name of dosage be that the suitable absorption of 1:4 is the four strong pharmacokinetics characteristics of multiplication). Other embodiment of Zai Zhong, when providing, the Zuo Yong site that gives Zai Yao thing of the moisture suction mixture of Yi Zhong can suck Yu Yi Zhong that suspension is compared larger absorption or while distributing, the pharmacokinetics characteristic that is enhanced, wherein, described moisture suction mixture Yi Yu the described identical nominal dosed administration of suspension that sucks. Some other embodiment Zhong of Zai, the strong pharmacokinetics characteristic of Zeng can to compare the Zeng Calais of the absorption at place, Zai drug effect site or distribution quantitative Yu sucking suspension according to moisture suction mixture. For example, some embodiment Zhong of Zai, when the following pharmacokinetics characteristic of demonstrating of the moisture suction mixture of Yi Zhong, when the numerical value that namely wherein represents the absorption in moisture suction mixture Zai drug effect site or distribution means the Zhi few two times (2X) of numerical value of the absorption that can suck suspension Zai drug effect site or distribution, obtain the pharmacokinetics characteristic of two times of Zeng Jia. The a little embodiment Zhong of Zai Yi, the described suspension that sucks can be Pulmicort, this can suck pharmacokinetics characteristic such as Pulmicort that suspension shows

The packing insert Zhong that commercial product (AstraZeneca LP, Wilmington Delaware, USA) comprises is described.

The a little embodiment Zhong of Zai Yi of the present invention, " the lung deposition that Zeng is strong " that Zhong of the present invention uses refers to the lung deposition of Yi Zhong compound, wherein, Yi Zhong pharmaceutical preparation (for example, moisture suction mixture) show than another kind of pharmaceutical preparation (for example, can suck suspension) the Zong lung deposition that Zeng adds. The a little embodiment Zhong of Zai Yi of the present invention, " the lung deposition that Zeng is strong " that Zhong of the present invention uses refers to the lung deposition of Yi Zhong compound, wherein, Yi Zhong pharmaceutical preparation (for example, moisture suction mixture) than another kind of pharmaceutical preparation (for example, can suck suspension) show suitable in fact Zong lung deposition, wherein, described moisture suction mixture Yi is lower than the nominal dosed administration that can suck suspension. The a little embodiment Zhong of Zai Yi, the described suspension that sucks can be Respules。

" the respirable part " used as Zhong of the present invention refer to leave atomizer or atomizer interface, aerodynamic diameter divides less than the Quality Mgmt Dept of the particle that contains the Yao thing of 5 microns Yue. Respirable part relates to the Yao agent amount of leaving atomizer, rather than the nominal dosage of the described atomizer Zhong of Zai.

" the strong agent of solubility Zeng " that Zhong of the present invention uses be included in or the situation that do not have chemical agent to work under the method for the strong solubility of Zeng is provided. Some embodiment Zhong of Zai, " the strong agent of solubility Zeng " can Zhi Yi Zhong can Zeng adds the chemical agent of the solubility of the second compound such as active component Zai solvent Zhong. Other embodiment of Zai Zhong, described chemical agent can also be the solvent of described the second compound. Other embodiment Zhong that Zai also has, described chemical agent is not the solvent of described the second compound. Other embodiment Zhong that Zai also has, " the strong agent of solubility Zeng " can Zhi Yi Zhong Zai do not have Zuo that the agent method processed of the solubility that Zeng adds is provided for Zeng adds under the chemical agent that the means of solubility work, for example, Yong super critical fluid Preparation Method produces the nano particle that Yong Yu Zai solvent Zhong disperses.

The a little embodiment Zhong of " being substantially devoid of " Zai Yi that Zhong of the present invention uses refer to that Yi Zhong comprises Zu compound or the mixture of single therapy active agent. Some embodiment Zhong of Zai, " be substantially devoid of " and refer to that Yi Zhong comprises Zu compound or the mixture of single therapy active agent, wherein, described Zu of compound or mixture do not comprise the second pharmaceutically active reagent of perceived amount, perhaps do not comprise and present in an amount at least sufficient to cause Zhi to treat active the second Zhong pharmaceutically active reagent.

" Zhi treats effective dose " or " effective dose " refer to realize the amount of the Yao thing of Yao effect of science. Term " Zhi treats effective dose " comprises for example anti-effective dose of Yu. " effective dose " of corticosteroid such as budesonide is that You effect realizes that needed Yao effect of science or Zhi treat and improves and do not cause the amount of unsuitable adverse side effect. Those skilled in the art is according to the degree meeting Xuan Ze corticosteroid of concrete patient and disease such as the effective dose of budesonide. Ying be somebody's turn to do understanding, the difference of You Yu corticosteroid such as budesonide metabolism, experimenter's age, body weight and general status are different, the illness that Zhi treats is different, the sanatory order of severity is different different with Zhu attending doctor's judgement, and " effective dose " or " Zhi treats effective dose " may change Yin the difference of experimenter and colony.

" the Zhi treatment " used aspect Zai Zhi tracheae constriction Zhang hinders refers to that Zhang that the Zhi tracheae shrinks hinders or any Zhi of disease treats to relating to, as, prevent that Yi Yu from suffering from that described Zhang hinders or disease but be not diagnosed as suffers from that described Zhang hinders or the experimenter of disease suffers from described Zhang and hinders or disease; The described Zhang of Yi Zhi hinders or disease, as, stop described Zhang and hinder or advancing of disease, alleviate described Zhang and hinder or disease, cause described Zhang to hinder or disease disappears, alleviate the illness that the described Zhang of You hinders or disease causes, perhaps the described Zhang of Zu Zhi hinders or the Zheng Zhuan of disease. Yin this, term used in the present invention " Zhi treatment " Yu term " Yu is anti-" or " preventing " have identical implication.

But I. provide the Zeng inhalation group compound that contains corticosteroid of strong lung deposition

But the invention provides the inhalation group compound, said composition contains corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, and the strong agent of described solubility Zeng can provide the lung deposition of the corticosteroid of comparing the strong conveying of Zeng Yu the corticosteroid that Yi suspension Xing formula gives by suction. The embodiment Zhong of Zai You Xuan, but inhalation group compound of the present invention is treated and is compared the lung deposition that the strong corticosteroid of carrying of Zeng is provided Yu the sucked corticosteroid Zhi of routine, and it provides the means that Yi Zhong reduces provides the needed dosage of topical therapeutic effect to go back You. Similarly, but provide from the inhalation group compound the fine grain method that produces, the method comprises the corticosteroid Zhong that solvent and the strong agent of solubility Zeng is joined effective dose, and operation atomizer Yi produces fine grained. Other embodiment of Zai Zhong, but method provided by the invention comprises the inhalation group compound, said composition is compared the strong lung deposition of Zeng that the corticosteroid of carrying is provided Yu conventional therapy, the present invention goes back You, and it provides Yi Zhong to reduce the means that the needed dosage of topical therapeutic effect is provided.

in addition, also providing Yong Yu Zhi to treat Zhi tracheae constriction Zhang hinders, method and system as asthma and/or COPD (COPD), the method is compared and can be carried the corticosteroid with the strong lung deposition of Zeng Yu the corticosteroid that gives by suction Yi suspension Xing formula with system, wherein, have You point under Yi Zhong or multiple Yi: Zeng by method and system administration of the present invention and add the lung deposition of the corticosteroid of being carried, reduce the method for the nominal dosage that the needed corticosteroid of topical therapeutic effect is provided, reduce the method for the corticosteroid required time that gives You effect dosage, Zeng adds the method for patient to the compliance of the therapeutic scheme that comprises the corticosteroid that sucks atomization, the method that the strong corticosteroid of Zeng is carried, the strong corticosteroid Zai of Zeng lung is the method for the amount of Zhi tracheae and alveolar deposition for example, with the method that reduces the side effect relevant to sucking corticosteroid.

But some aspect of the present invention relates to the inhalation group compound, said composition comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, wherein, when Zai gives the experimenter by atomizer with described Zu of compound, described Zu of compound realized the amount of the corticosteroid of described mixture Zhong before administration, Yue 20%-55%, Yue 20%-50% or Yue the lung deposition of 20%-40%, for example Zhi tracheae and alveolar. Some embodiment Zhong of Zai, but described inhalation group compound comprises single corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, and be substantially devoid of other active medicine except the cortex steroids Zhi. The amount that other embodiment Zhong that Zai also has, described Zu of compound can realize the corticosteroid of described mixture Zhong before administration is the lung deposition of 20%-55% Yue. The amount that other embodiment of Zai Zhong, described Zu of compound can realize the corticosteroid of described mixture Zhong before administration is the lung deposition of 25%-45% Yue. The amount that some embodiment Zhong of Zai, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 25% lung deposition. The amount that other embodiment of Zai Zhong, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 30% lung deposition. The amount that other embodiment Zhong that Zai also has, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 35% lung deposition. The amount that other embodiment Zhong that Zai still also has, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 40% lung deposition. The amount that other embodiment of Zai Zhong, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 45% lung deposition. The amount that other embodiment Zhong that Zai also has, described Zu of compound can realize the corticosteroid of described Zu of compound Zhong before administration is at least about 55% lung deposition. Zai Yi Zhong embodiment Zhong, described corticosteroid is budesonide. Zai another embodiment Zhong, described corticosteroid are budesonide, wherein, this budesonide be independent diastereoisomer or separately or Yi work the mixture of the two Zhong diastereoisomers that are administered for Zhi curative effect fruit. Some embodiment Zhong of Zai, but described inhalation group compound comprises single corticosteroid and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except the cortex steroids Zhi. Other embodiment Zhong that Zai also has, but described inhalation group compound comprises budesonide, solvent and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except budesonide Zhi.

Zai certain embodiments of the present invention Zhong, but also realize respirable part at least about 60% while comprising the inhalation group compound Zai administration of corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Zai Yi of the present invention preferred embodiment Zhong, also realize the respirable part at least about 70% during described Zu of compound Zai administration. Zai also preferred embodiment Zhong of the present invention, also realize the respirable part at least about 80% during described Zu of compound Zai administration. Zai Yi of the present invention most preferred embodiment Zhong, also realize the respirable part at least about 85% during described Zu of compound Zai administration. Some embodiment Zhong of Zai, but described inhalation group compound comprises single corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except the cortex steroids Zhi.

The a little embodiment Zhong of Zai Yi of the present invention, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 15-2000 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Some embodiment Zhong of Zai, but described inhalation group compound comprises single corticosteroid, solvent and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except the cortex steroids Zhi. Other embodiment of Zai Zhong, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 250-2000 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Other embodiment Zhong that Zai also has, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 60-1500 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Other embodiment Zhong that Zai also has, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 100-1000 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Other embodiment Zhong that Zai also has, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 120-1000 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Other embodiment Zhong that Zai still also has, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 125-500 μ g Yue Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Some embodiment Zhong of Zai, but the inhalation group compound that comprises corticosteroid, solvent and the strong agent of solubility Zeng of effective dose comprises the quantitative corticosteroid of Yi, the amount of the corticosteroid of described Zu of compound Zhong of Zai is 40, Yue 60, Yue 100, Yue 120, Yue 125, Yue 240, Yue 250, Yue 500, Yue 1000, Yue 1500 or Yue 2000 μ g Yue before the Zai administration, and the strong agent of described solubility Zeng can provide the strong lung deposition of Zeng. Zai Yi Zhong embodiment Zhong is the corticosteroid of 40 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. Zai another embodiment Zhong is the corticosteroid of 60 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. The another Zhong embodiment of Zai Zhong is the corticosteroid of 100 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. The another embodiment Zhong of Zai You You is the corticosteroid of 120 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. The another embodiment Zhong that Zai also has is the corticosteroid of 125 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. The another embodiment Zhong of Zai You You is the corticosteroid of 240 μ g Yue but described inhalation group compound comprises the amount of the corticosteroid of Zu compound Zhong before administration. The another embodiment Zhong that Zai also has, but the amount that described inhalation group compound comprises the corticosteroid of Zu compound Zhong before administration is for less than the corticosteroid of 250 μ g Yue. Zai another embodiment Zhong, but the amount that described inhalation group compound comprises the corticosteroid of Zu compound Zhong before administration is for less than the corticosteroid of 500 μ g Yue. Zai Yi Zhong embodiment Zhong, described corticosteroid is budesonide. Zai another embodiment Zhong, described corticosteroid is budesonide, wherein this budesonide be independent diastereoisomer or separately or Yi work the mixture of the two Zhong diastereoisomers that are administered for Zhi curative effect fruit. Some embodiment Zhong of Zai, but described inhalation group compound comprises single corticosteroid and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except the cortex steroids Zhi. Other embodiment Zhong that Zai also has, but described inhalation group compound comprises budesonide and the strong agent of solubility Zeng of effective dose, and be substantially devoid of the active medicine except budesonide Zhi.

Some embodiment Zhong of Zai, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 40 μ g, wherein, when Zai gave the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 15 μ g. The embodiment Zhong of Zai some other, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 60 μ g, wherein, when Zai gave the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 20 μ g. Other embodiment Zhong that Zai also has, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 120 μ g, wherein, when Zai gave the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 40 μ g. Other embodiment Zhong of Zai You You, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 240 μ g, wherein, when Zai gave the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 80 μ g.

Some embodiment Zhong of Zai, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 40 μ g, wherein, when Zai gives the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 13 μ g, wherein, described Zu of compound is substantially devoid of the active medicine Zhi budesonide. The embodiment Zhong of Zai some other, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 60 μ g, wherein, when Zai gives the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 20 μ g, wherein, described Zu of compound is substantially devoid of the active medicine Zhi budesonide. Other embodiment Zhong that Zai also has, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 120 μ g, wherein, when Zai gives the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 40 μ g, wherein, described Zu of compound is substantially devoid of the active medicine Zhi budesonide. Other embodiment Zhong of Zai You You, but described inhalation group compound can comprise Yue budesonide, solvent and the strong agent of solubility Zeng of 240 μ g, wherein, when Zai gives the experimenter by atomizer with described Zu of compound, described Zu of compound realized the lung deposition at least about the budesonide of 80 μ g, wherein, described Zu of compound is substantially devoid of the active medicine Zhi budesonide.

The a little embodiment Zhong of Zai Yi, but the suitable inhalation group compound that comprises corticosteroid includes but not limited to solution, dispersion, nanometer dispersion, emulsion, colloidal solution, micella or mixed micelle solution and liposome Ye body. Zai Yi Zhong embodiment Zhong, described moisture suction mixture are the solution that comprises corticosteroid such as budesonide and the strong agent of solubility Zeng. Zai another embodiment Zhong, described moisture suction mixture are the mixed micelle solution that comprises corticosteroid such as budesonide and the strong agent of solubility Zeng. The another embodiment Zhong that Zai also has, described moisture suction mixture are the liposome solution that comprises corticosteroid such as budesonide and the strong agent of solubility Zeng.

The a little embodiment Zhong of Zai Yi of the present invention, but the inhalation group compound that comprises corticosteroid does not comprise nanometer dispersion and/or nanometer suspension. Other embodiment of Zai Zhong, but the inhalation group compound that comprises corticosteroid does not comprise micella, mixed micelle Ye body or liposome Ye body. Other embodiment Zhong that Zai also has, but the inhalation group compound that comprises corticosteroid does not comprise nanometer dispersion and/or nanometer suspension, micella, mixed micelle Ye body or liposome Ye body. Other embodiment of Zai Zhong, but the inhalation group compound includes but not limited to solution, emulsion and colloidal solution. Zai Yi Zhong embodiment Zhong, but described inhalation group compound is the solution that comprises corticosteroid such as budesonide and the strong agent of solubility Zeng. Zai another embodiment Zhong, but described inhalation group compound is the emulsion that comprises corticosteroid such as budesonide and the strong agent of solubility Zeng.

but the corticosteroid of the inhalation group compound that Yong Yu the present invention describes includes but not limited to aldosterone, beclomethasone, betamethasone, budesonide, ciclesonide, Cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, FA, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), Halcinonide, hydrocortisone, Chinese mugwort Cormetasone (icomethasone), methylprednisolone (meprednisone), Methyllprednisolone (methylprednisolone), Mometasone (mometasone), paramethasone, prednisolone (prednisolone), metacortandracin (prednisone), rofleponide, RPR 106541, Tixocortol (tixocortol), acceptable derivates on fluoxyprednisolone (triamcinolone) and their Yao separately. the embodiment Zhong of Zai You Xuan, described corticosteroid is budesonide. the embodiment Zhong of other You Xuan of Zai, described corticosteroid is budesonide, wherein this budesonide be independent diastereoisomer or separately or Yi work the mixture of the two Zhong diastereoisomers that are administered for Zhi curative effect fruit.

But some embodiment Zhong of the inhalation group compound that Zai the present invention describes, but described inhalation group compound comprises solvent. Some embodiment Zhong of Zai, described solvent Xuan Zi water, aqueous alcohol, propane diols or water-containing organic solvent. The embodiment Zhong of Zai You Xuan, described solvent is water.

But other embodiment Zhong of the inhalation group compound that Zai the present invention describes, but described inhalation group compound comprises the strong agent of solubility Zeng. The a little embodiment Zhong of Zai Yi, the strong agent of described solubility Zeng can have the Yue concentration of 0.001%-25% (w/v). Other embodiment of Zai Zhong, the strong agent of described solubility Zeng can have the Yue concentration of 0.01%-20% (w/v). Other embodiment Zhong that Zai also has, the strong agent of described solubility Zeng can have the Yue concentration of 0.1%-15% (w/v). Other embodiment Zhong of Zai You You, the strong agent of described solubility Zeng can have the Yue concentration of 1%-10% (w/v). The embodiment Zhong of Zai You Xuan, when the strong agent of described solubility Zeng is cyclodextrin or cyclodextrine derivatives such as SBE7-β-CD

The time, the strong agent of described solubility Zeng can have the Yue concentration of 2%-10% (w/v). Zai Yi Zhong embodiment Zhong, when the strong agent of described solubility Zeng is cyclodextrin or cyclodextrine derivatives such as SBE7-β-CDThe time, the strong agent of described solubility Zeng can have Yue 2% concentration (w/v). Zai another embodiment Zhong, when the strong agent of described solubility Zeng is cyclodextrin or cyclodextrine derivatives such as SBE7-β-CD

The time, the strong agent of described solubility Zeng can have Yue 5% concentration (w/v). The another Zhong embodiment of Zai Zhong, when the strong agent of described solubility Zeng is cyclodextrin or cyclodextrine derivatives such as SBE7-β-CD

The time, the strong agent of described solubility Zeng can have Yue 7% concentration (w/v). Zai also has another embodiment Zhong, when the strong agent of described solubility Zeng is cyclodextrin or cyclodextrine derivatives such as SBE7-β-CD

The time, the strong agent of described solubility Zeng can have Yue 10% concentration (w/v).

The chemical agent that is suitable for Zuo of the present invention and is the strong agent of solubility Zeng includes but not limited to that propane diols, non-ionic surface active agent, phosphatide, cyclodextrin and Yan thereof are biological, surface modifier and/or stabilizing agent. Other embodiment of Zai Zhong, the strong agent of solubility Zeng refers to Zai does not rise provides the strong solubility of Zeng under the chemical agent that means that Zeng adds solubility are used as agent method processed, for example, Yong super critical fluid Preparation Method produces the nano particle that Yong Yu Zai solvent Zhong disperses.

That but the strong agent of solubility Zeng that is suitable for the inhalation group compound that the present invention describes in addition is known in the art and be described in United States Patent (USP) 5,134,127,5,145,684,5,376,645 and 6,241,969 Yi and U.S. Patent Application Publication 2005/0244339 and 2005/0008707 Zhong, they all concrete Yin to enter Zuo of the present invention be reference. In addition, the example of the suitable strong agent of solubility Zeng is described below.

This area has been described and has been suitable for cyclodextrin of the present invention and Yan biology thereof, for example, Challa etc., AAPS PharmSciTech6 (2): E329-E357 (2005), United States Patent (USP) 5,134,127,5,376,645 and 5,874,418, they all concrete Yin to enter Zuo of the present invention be reference. The a little embodiment Zhong of Zai Yi, be suitable for cyclodextrin of the present invention or cyclodextrine derivatives include but not limited to alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, SAE-CD Yan biological (for example, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD (

) (the Cydex of and SBE-γ-CD), Inc. Lenexa, KS), Qiang ethylether, hydroxypropyl ether (comprising 2-and 3-hydroxypropyl ether) and dihydroxypropyl ether, their corresponding compound ether Yi and the compound ether that also Yu the ether with methyl or Yi base, mixes, described ether with methyl or Yi base such as α-, β-and methyl Qiang benzyl ethyl ether, Yi base Qiang benzyl ethyl ether and the basic hydroxypropyl ether of Yi of gamma-cyclodextrin, and α-, β-and Fructus Hordei Germinatus glycosyl, glucosyl group and the maltotriose radical derivative of gamma-cyclodextrin, they can comprise Yi Zhong or multiple sugared residue, for example glucosyl group or glucosulfone base, Fructus Hordei Germinatus glycosyl or two Fructus Hordei Germinatus glycosyls, Yi and their various mixtures, for example, the mixture of Fructus Hordei Germinatus glycosyl and two maltose radical derivatives. Yong Yu concrete cyclodextrine derivatives of the present invention comprises HP-β-CD, Qiang Yi group-beta-cyclodextrin, hydroxypropyl-gamma-cyclodextrin, Qiang Yi base-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-alpha-cyclodextrin, the maltose group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-gamma-cyclodextrin, G 3-β-CD, maltotriose base-gamma-cyclodextrin, two maltose group-beta-cyclodextrins, DE-β-CD, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, three-O-methyl-beta-schardinger dextrin-, three-O-Yi base-β-cyclodextrin, three-O-butyryl group-beta-cyclodextrin, three-O-valeryl group-beta-cyclodextrin and two-O-hexanoyl group-beta-cyclodextrin, Yi and methyl-beta-schardinger dextrin-, with their mixture, as Fructus Hordei Germinatus glycosyl-β-cyclodextrin/two maltose group-beta-cyclodextrins. the method of the standby this cyclodextrine derivatives of Zhi is known, for example can be from United States Patent (USP) 5,024,998 and Yin enter Zhong the list of references that Zuo of the present invention is reference to know. other is suitable for cyclodextrin of the present invention and comprises that carboxyalkyl thioether Yan is biological, the ORG 26054 and the ORG 25969 that provide as You ORGANON (AKZO-NOBEL), the Qiang base cyclobutenyl ether Yan that You EASTMAN provides is biological, sulfoalkyl-hydroxyalkyl ether Yan is biological, sulfoalkyl-alkyl ether Yan is biological, biological with other Yan, for example U.S. Patent application 2002/0128468, 2004/0106575, 2004/0109888 and 2004/0063663, or United States Patent (USP) 6, 610, 671, 6, 479, 467, 6, 660, 804 or 6, 509, 323 described those, they all concrete Yin to enter Zuo of the present invention be reference.

HP-β-CD can obtain from Research Diagnostics Inc. (Flanders, NJ). Exemplary HP-β-CD product comprises

(substitution value be Yue 4) and

(substitution value be Yue 8); Yet, the embodiment that comprises other substitution value can also obtain and Zai scope of the present invention in.

The dimethyl cyclodextrin can obtain from FLUKA Chemie (Buchs, CH) or Wacker (Iowa). Other cyclodextrin that is suitable for derivatization of the present invention comprises the cyclodextrin of water miscible derivatization. The cyclodextrin of exemplary water-soluble derivatization comprises carboxylated Yan biology, sulphation Yan biology, alkyl derivative, Qiang base alkyl derivative, methylate Yan biology and Suo group-beta-cyclodextrin, for example, and succinyl group-beta-cyclodextrin (SCD). All these Yuan material is can be according to methods known in the art Zhi standby and/or can be commercially available. The cyclodextrin of the derivatization that is fit to is disclosed in Modified Cyclodextrins:Scaffoldsand Templates for Supramolecular Chemistry (Eds.Christopher J.Easton, Stephen F.Lincoln, Imperial College Press, London, UK, 1999) and New Trends in Cyclodextrins and Derivatives (Ed.Dominique Duchene, Editions de Sant é, Paris, France, 1991) Zhong.

as if the Yong Yu example that has the non-ionic surface active agent of particularly preferred physiological compatibility of the present invention be tyloxapol (tyloxapol), polysorbate, polysorbate include but not limited to polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) anhydrosorbitol monopalmitate, polyoxyethylene (20) anhydrosorbitol monostearate (the Yi commodity are called the acquisitions such as Tweens 20-40-60), polysorbate80, PEG400, NaLS, sorbitan laurate, sorbitan palmitate, sorbitan stearate (the Yi commodity are called the acquisitions such as Span 20-40-60), benzalkonium chloride (benzalkonium chloride), PPO-PEO block copolymer (Pluronics), Cremophor-EL, vitamin E-TPGS (as, d-α-fertility base (tocopheryl)-PEG-6000-succinate), Solutol-HS-15, You acid PEO Zhi, Ying Zhi acid PEO Zhi, Triton-X100, Nonidet P-40 and polyethylene glycol (macrogol) hydroxy stearic acid Zhi such as polyethylene glycol-15 hydroxy stearic acid Zhi.

The a little embodiment Zhong of Zai Yi, be suitable for non-ionic surface active agent of the present invention Yu corticosteroid Yi and play preparation Yi Xing and become liposome agent processed, micella or mixed micelle. The standby method Zai this area Zhong with characterization of liposomes and liposome agent processed of Zhi is Yi Zhi. Usually, when the Zhi of amphiphilic Zhi can Zi during by hydration send out Xing, become the multilayer bubble, and the Xing of little individual layer bubble becomes common Xu Yao relate to the process of a large amount of energy inputs, for example, ultrasonication or high pressure homogenize. The standby method Yi with characterization of liposomes of other Zhi is described (Preparation and characterization of liposomes as therapeutic delivery systems:a review.Pharm Acta HeIv.1995 by people such as Zhu Ru S.Vemuri, 70 (2): 95-111), and be described in United States Patent (USP) 5,019,394,5,192,228,5,882,679,6,656,497 Zhong, they all concrete Yin to enter Zuo of the present invention be reference.

Under the Zai certain situation. For example, micella or mixed micelle can become by You surfactant Xing, and the poor active agent of dissolubility can be dissolved in wherein. Usually, the micella spherical structure substantially that is understood to that Zi by amphiphile, amphiphilic molecule such as surfactant sends out that Xing becomes with dynamically associating. Mixed micelle is the micella that the dissimilar amphiphile, amphiphilic molecule of You forms. Micella and mixed micelle both should not be construed as solid particle, Yin structure, Xing Zhi and Hang for them, are that the Yu solid differs greatly. Xing associates while becoming the common Zan of amphiphile, amphiphilic molecule of micella. , there is dynamic molecule exchange in Zai micellar solution Zhong between Zhi the amphiphile that the Yi unimolecule Xing formula that Xing becomes the amphiphile of micella Yu also exists in solution is disperseed. The structure Yi of a little molecules of Zhe and the surfactant that is used are depended in the position that is dissolved in the intrafascicular drug molecule of this micella or epoxy glue. For example, suppose that nonpolar molecule Zhu particularly Yao be positioned at the inside of colloform texture, and polar substances more may be positioned at surface. The Yi of Zai micella or mixed micelle solution embodiment Zhong, the mean size of micella can be less than 200nm (Yong photon correlation spectroscopy (photon correlation spectroscopy) detection) Yue, for example 10-100nm Yue. Particularly preferably average diameter is the micella of 10-50 nm Yue. The method of the standby micella of Zhi and mixed micelle is known in the art, and is described in for example United States Patent (USP) 5,747,066 and 6,906,042 Zhong, they all concrete Yin to enter Zuo of the present invention be reference.

Phosphatide is defined as containing the amphipathic lipid Zhi of phosphorus. Extensively there is and is generally used for Yao thing purpose from the chemically derived phosphatide of phosphatidic acid. This acid is generally the glycerol-3-phosphate of (two) Xianization, and wherein, fatty acid residue can have different length. The Yan biology of described phosphatidic acid comprises, for example, phosphocholine or phosphatid ylcholine, wherein, phosphate group, by choline Zhiization extraly, also has phosphatidyl-ethanolamine, phosphatidylinositols etc. Lecithin is the natural mixture that usually has the various phosphatide of a high proportion of phosphatid ylcholine. The source and extraction and/or the enrichment method that depend on special lecithin, a little mixtures of Zhe also may comprise a large amount of sterol, the acid of Zhi fat, triglycerides and other material.

The phosphatide that other their physiological property of You Yu is fit to carry by suction comprises, You it be, the Xing formula of Yi lecithin is from natural source as the phosphatide mixture that extracts of soybean or egg yolk, You Xuan Yi hydrogenated form and/or do not contain lysolecithin, the synthetic standby phosphatide of Zhi of Yi and purifying, enrichment or part, You Xuan has polyunsaturated fatty acid ester. Zai phosphatide mixture Zhong, lecithin is particularly preferred. Medium chain described enrichment or that the synthetic Zhi of part is standby is not contained in unsaturated on Xian base chain to long-chain zwitterionic phospholipid Zhu Yao, and does not contain lysolecithin and peroxide. The example of enrichment or purifying compounds is dimyristoyl phosphatidyl choline (DMPC), DSPC (DSPC) and DPPC (DPPC). The a little material Zhong of Zai Zhe, DMPC is preferred at present. Alternatively, there is no the phosphatide of oleoyl residue and do not have the phosphatidyl glycerol of choline residue to be suitable for a little embodiments of Yi of the present invention and Ying Yong.

The a little embodiment Zhong of Zai Yi, be suitable for non-ionic surface active agent of the present invention and become colloform texture with phosphatide Yu corticosteroid preparation Yi Xing. Colloidal solution is defined as single_phase system, and wherein, the colloidal materials that is dispersed in colloidal solution Zhong does not have measurable, the common physical property relevant to solid material. The method of the standby aqueous colloidal dispersion of Zhi is known in the art, and for example, 6,653,319 Zhong are described for the Zai United States Patent (USP), and it is reference that the concrete Yin of this Zhuan profit enters Zuo of the present invention.

Yong Yu suitable surface modifier of the present invention is known in the art, and for example United States Patent (USP) 5,145,684,5,510,118,5,565,188 and 6,264,922 descriptions, they all concrete Yin to enter the application Zuo be reference. be suitable for the example of surface modifier of the present invention and/or surface stabilizer including, but not limited to hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, NaLS, dioctyl sodium sulfosuccinate, gel, casein, lecithin (phosphatide), glucan, Arabic gum, cholesterol, bassora gum, Ying Zhi acid, benzalkonium chloride, calcium stearate, glyceryl monostearate, the cetanol stearyl alcohol, cetanol polyethylene glycol emulsifying wax, anhydrosorbitol Zhi, polyoxyethylene alkyl ether (as, polyglycol ether such as cetanol cetomacrogol 1000), castor oil derivatives, the polyoxyethylene sorbitan fatty acid ester (as, commercially available Tweens^TM, for example Tween 20^TMWith Tween 80^TM(ICI Specialty Chemicals)), polyethylene glycol (as, Carbowaxs 3550^TMWith 934^TM(Union Carbide)), Myrj 45, cataloid, phosphate, calcium carboxymethylcellulose, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, Hydroxypropyl Methylcellulose Phathalate, amorphous cellulose element, aluminium-magnesium silicate, triethanolamine, polyvinyl alcohol (PVA), 4-(1,1,3,3-tetramethyl butyl)-phenol is (Pluronics F68 for example Yu the polymer of oxirane and formaldehyde (also is called tyloxapol, superione and triton), poloxamer (poloxamers)^TMAnd F108^TM, they are block copolymers of oxirane and expoxy propane), (for example Tetronic 908 for poloxamines^TM, also is called Poloxamine 908^TM, it is that You expoxy propane and oxirane sequentially add to the four function block copolymers (BASF Wyandotte Corporation, Parsippany, NJ.) on the Yi diamines), Tetronic 1508^TM(T-1508)(BASF Wyandotte Corporation)、Tritons X-200 ^TM, it is alkyl aryl polyether sulphonic acid ester (Rohm and Haas), Crodestas F-100^TM, it is the mixture (Croda Inc.) of sucrose stearate and sucrose distearate, p-Yi Nonylphenoxy poly epihydric alcohol, also is called Olin-IOG^TMOr Surfactant 10^TM(Olin Chemicals, Stamford, Conn.), Crodestas SL-40.RTM. (Croda, Inc.) and SA9OHCO, it is C18H37CH2 (CON (CH3)-CH2 (CHOH) 4 (CH2OH) 2 (Eastman Kodak Co.), capryl-N-methyl glucose amide (glucamide), Zheng-decyl-β-D-glucopyranoside, Zheng-decyl-β-D-Bi Nan maltoside, Zheng-dodecyl β-D-glucopyranoside, Zheng-dodecyl β-D-maltoside, heptanoyl group-N-methyl glucose amide, Zheng-heptyl-β-D-glucopyranoside, Zheng-heptyl-β-D-Qiu base glucoside, Zheng-heptyl-β-D-glucopyranoside, pelargonyl group-N-methyl glucose amide, Zheng-noyl-β-D-glucopyranoside, caprylyl-N-methyl glucose amide, Zheng-octyl group-β-D-glucopyranoside, octyl group β-D-Bi Nan Qiu base glucoside (thioglucopyranoside), PEG-phosphatide, the PEG-cholesterol, the PEG-cholesterol derivative, the PEG-vitamin A, the PEG-vitamin E, lysozyme, (for example, the hydroxypropyl methylcelluloses such as random copolymer of vinyl pyrrolidone and vinyl acetate, hydroxypropyl cellulose, polyvinylpyrrolidone, the vinyl acetate copolymer, vinylpyrrolidone, NaLS and dioctyl sodium sulfosuccinate).

The Yang ion stabilizer of other You Yong includes but not limited to Yang ion Zhi Zhi, Liu, Phosphonium and quaternary ammonium compound, as Ying Zhi base trimethyl ammonium chloride, benzyl-two (2-chloro Yi yl) bromic ether An, Ye You trimethyl chlorination or ammonium bromide, the dihydroxy ethyl chlorination of Ye You methyl or ammonium bromide, decyl triethyl ammonium chloride, decyl dimethyl Qiang ethyl chloride or ammonium bromide, C_12-15Dimethyl Qiang ethyl chloride or ammonium bromide, Ye You dimethyl Qiang ethyl chloride or ammonium bromide, myristyl trimethyl methylsulfuric acid An, the chlorination of lauryl dimethyl benzyl or ammonium bromide, lauryl dimethyl (ethyleneoxy) 4 chlorinations or ammonium bromide, N-alkyl (C_12-18) dimethyl benzyl ammonium chloride, N-alkyl (C_14-18) dimethyl benzyl ammonium chloride, N-myristyl dimethyl benzyl (tetradecylidmethylbenzyl) ammonium chloride monohydrate, dimethyl lauryl ammonium chloride (dimethyldidecyl ammonium chloride), N-alkyl and (C_12-14) dimethyl 1-Nai ylmethyl ammonium chloride, trimethyl ammonium halide, alkyl-leptodactyline and dialkyl group-dimethyl ammonium, lauryl trimethyl ammonium chloride, alkylamide (alkyamido) the alkyl dialkyl ammonium salt of ethoxylation and/or trialkyl ammonium Yan, dialkyl benzene dialkylammonium chloride, N-dodecyl (N-didecyl) alkyl dimethyl ammonium chloride, N-myristyl dimethyl benzyl ammonium chloride monohydrate, the N-alkyl (C of ethoxylation_12-14) dimethyl 1-Nai ylmethyl ammonium chloride and dodecyl benzyl dimethyl ammonium chloride, dialkyl benzene alkyl ammomium chloride, lauryl trimethyl ammonium chloride, alkyl benzyl ammonio methacrylate, alkyl benzyl dimethyl ammonium bromide, C₁₂、C ₁₅、C ₁₇Trimethylammonium bromide, dodecylbenzyl triethyl ammonium chloride, diallyl dimethyl ammoniumchloride (DADMAC), alkyl dimethyl ammonium chloride, alkyl dimethyl ammonium halide, three cetyl ammonio methacrylates, DTAB, dodecyl triethyl group ammonium bromide, TTAB, (AL1QUAT 336 for methyl tricapryl ammonium chloride^TM)、POLYQUAT 10 ^TM, Xiuization TBuA, benzyltrimethylammonium bromide, cholinester (as the cholinester of Zhi fat acid), benzalkonium chloride, chlorination stearalkonium compound (for example Ying Zhi base trimethyl ammonium chloride (stearyltrimonium chloride) and VARISOFT TA100 (Di-stearyldimonium chloride)), chlorination or cetylpyridinium bromide, quaternised polyoxy Yi pheynylalkylamine halide Yan, Mirapol^TMAnd ALKAQUAT^TM(Alkaril Chemical Company), Fixanol; Amine, for example alkylamine, dialkylamine, alkanolamine, polyethylenepolyamine, acrylic acid N, N-dialkyl aminoalkyl ester and Yi alkenyl pyrimidine; Amine salt, as Yi acid lauryl amine, Yi acid stearylamine, Fixanol and alkyl imidazole Yan, with amine oxide, Xian Ya amine azolinium Yan, protonated season acrylamide, the season polymer that methylates, as poly-[diallyldimethylammonium chloride] and poly--[N-ethylene methacrylic yl pyridines chloride] and Yang ion guar gum.

some embodiment Zhong of Zai, but inhalation group compound of the present invention comprises the strong agent of solubility Zeng, the strong agent Xuan of this solubility Zeng Zi propane diols, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, polyethylene glycol (macrogol)-15 hydroxy stearic acid Zhi, phosphatide, lecithin, lecithin purifying and/or enrichment, the phosphatid ylcholine part that You lecithin extracts, dimyristoyl phosphatidyl choline (DMPC), DPPC (DPPC), DSPC (DSPC), cyclodextrin and Yan thereof are biological, SAE-CD Yan is biological, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD (), SBE-γ-CD, dimethyl beta-CD, HP-β-CD, 2-HP-β-CD, Qiang Yi group-beta-cyclodextrin, hydroxypropyl-gamma-cyclodextrin, Qiang Yi base-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-alpha-cyclodextrin, the maltose group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-gamma-cyclodextrin, G 3-β-CD, maltotriose base-gamma-cyclodextrin, two maltose group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, carboxyalkyl thioether Yan is biological, ORG 26054, ORG 25969, hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, the vinyl acetate copolymer, vinyl pyrrolidone, NaLS, dioctyl sodium sulfosuccinate and Zu thereof close. some embodiment Zhong of Zai, the strong agent of described solubility Zeng is SBE7-β-CD

Some other embodiment Zhong of Zai, but inhalation group compound of the present invention comprises the strong agent of solubility Zeng of the following material of Xuan Zi: cyclodextrin and Yan biology thereof, SAE-CD Yan biology, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-β-CD, 2-HP-β-CD, Qiang Yi group-beta-cyclodextrin, hydroxypropyl-gamma-cyclodextrin, Qiang Yi base-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-alpha-cyclodextrin, the maltose group-beta-cyclodextrin, Fructus Hordei Germinatus glycosyl-gamma-cyclodextrin, G 3-β-CD, maltotriose base-gamma-cyclodextrin, two maltose group-beta-cyclodextrins, methyl-beta-schardinger dextrin-. some embodiment Zhong of Zai, the strong agent of described solubility Zeng is SBE7-β-CD

But Zhi the moisture suction mixture or inhalation group compound that comprise corticosteroid and the strong agent of solubility Zeng, the present invention is the Yu phase also, some embodiment Zhong of Zai, You provide moisture suction mixture or the Zu compound of the method preparation of the strong solubility of Zeng to be equally applicable to invention disclosed herein. Yin this, Zai the context of the invention Zhong, " the strong agent of solubility Zeng " is included in or there is no the moisture suction mixture of Zuo for the method preparation by the strong solubility of Zeng is provided in the situation of the chemical agent of the strong agent of solubility Zeng. This method comprises that for example the Zhi of supercritical fluid is standby. According to this method, with corticosteroid Zu compound Zao as processed in budesonide become to have Zhai particle size distribution (usually wide less than 200 nanometers), the average hydrodynamic radius of particle is the particle of 50 nanometers-700 nanometer. The corticosteroid particle of nanometer size is to use supercritical fluid (SCF) method Zao processed as the budesonide particle, described supercritical fluid (SCF) method comprises the rapid expanding (RESS) of supercritical solution, or the solution Zeng of supercritical fluid disperses by force (SEDS) Yi and any other to relate to the technology of supercritical fluid. Use SCF method Xing to become the Zong of particle to state and see Palakodaty, S. etc., Pharmaceutical Research 16:976-985 (1999), and be described in Bandi etc., Eur.J.Pharm.Sci.23:159-168 (2004), United States Patent (USP) 6,576,264 and U.S. Patent application 2003/0091513 Zhong, they all concrete Yin to enter Zuo of the present invention be reference. The a little method Yun Xu of Zhe Yi becomes to have micron and the very little particle of sub-micro meter ruler of different shape according to selected method and parameter Xing. In addition, a little nano particles of Zhe can carry out Zao processed by any other conventional method that spray-drying, freeze drying, volume exclusion (volume exclusion) and particle reduce.

And the method for the standby nanometer sized particles of described Zhi comprises that SCF can Yun Xu precipitate by Zai or condensation course Zhong suitably regulates granuloplastic condition and carrys out the Xing state of Xuan Ze expectation (for example unformed, crystallization or fractionation is racemic). The particle form of You Yu Xuan Ze expectation, the long release of Yan that can realize the Yao thing of Xuan Ze. The a little method for making granules Yong of Zhe Yu obtains to have high-purity, hangs down surperficial imperfection, hangs down the nano particle of surface charge and low deposition rate. This particle characteristic Yi particle bond processed, agglomeration, also prevent Zai Ye body dispersion Zhong sedimentation. In addition,, because being the isomery body that method such as SCF can separate some drugs, so having the strong activity of Zhu Yu Yao thing Zeng, You effect Xing Yi and dosage extremely, this separation reduces. Under the Zai certain situation, the isomery body separates the side effect that also has Zhu Yu to reduce. According to the inventive method and system; moisture suction mixture can be that the Zu compound, the Zhi that comprise by any method SCF, spray-drying, precipitation and volume exclusion (volume exclusion) Zao powdered Xing processed formula meets Zao processed and enter the Zu compound of trapping medium, and wherein the granulating compound becomes the agent processed of dispersion Yin the moving Xing of Zi. The a little embodiment Zhong of Zai Yi, said preparation can be the agent processed of Zui Zhong.

Zai other embodiment of the present invention Zhong, but described inhalation group compound also can comprise the second therapeutic agent, and this second therapeutic agent Xuan Zi beta 2-adrenergic receptor agonist, dopamine (D2) receptor stimulating agent, anticholinergic and Yu prevent therapeutic agent. The a little embodiment Zhong of Zai Yi of the present invention, the second therapeutic agent are the beta 2-adrenergic receptor agonists of Xuan Zi salbutamol (albuterol), Zuo Xuan salbutamol (levalbuterol) or its Yao acceptable derivates.

(α-1-(((1 but the beta 2-adrenergic receptor agonist of Yong Yu inhalation group compound provided by the invention includes but not limited to salbutamol, the 1-dimethyl ethyl) amino) methyl)-4-Qiang base-1, the 3-benzene dimethanol), ((2-((1 for dimethylamino formic acid 5-for bambuterol (Bambuterol), the I-dimethyl ethyl) amino)-1-Qiang Yi yl)-1, 3-phenylene Zhi), ((2-((1 for 4-benzoin methyl acid 4-for bitolterol (Bitolterol), the 1-dimethyl ethyl) amino)-1-Qiang Yi yl)-1, 2-phenylene Zhi), Broxaterol (Broxaterol) (3-Xiu-α-(((1, the 1-dimethyl ethyl) amino) methyl)-5-Yi Evil Zuo methyl alcohol), isonorin (4-(1-Qiang base-2-((1-Methylethyl-) amino) Yi yl)-1, 2-benzene-glycol), Trimetoquinol (1, 2, 3, 4-tetrahydrochysene-1-((3, 4-, the 5-trimethoxyphenyl)-methyl)-6, 7-Yi Kui Lin glycol (isoquinolinediol)), (4-amino-3 for Clenbuterol (Clenbuterol), 5-two chloro-α-(((1, the 1-dimethyl ethyl) amino) methyl) phenmethylol), fenoterol (Fenoterol) (5-(1-Qiang base-2-((2-(4-oxybenzene base)-1-Methylethyl) amino) Yi yl)-1, the 3-Benzenediol), Formoterol (Formoterol) (2-Qiang base-5-((1 RS)-1-Qiang base-2-(((1RS)-2-(p-methoxyphenyl)-1-Methylethyl) amino) Yi yl) N-formailide), (R, R)-Formoterol, Desformoterol ((R, R) or (S, S)-3-amino-4-hydroxyl-alpha-(((2-(4-methoxyphenyl)-1-methyl-Yi yl) amino) methyl) phenyl methanol), Hexoprenaline (Hexoprenaline) (4, 4 '-(1, 6-hexane-two base (diyl))-two (amino (1-Qiang bases-2 of Ya, 1-Yi two bases (ethanediyl)))) two-1, the 2-Benzenediol), neoisuprel (Isoetharine) (4-(1-Qiang base-2-((1-Methylethyl) amino) butyl)-1, the 2-Benzenediol), isoprel (lsoprenaline) (4-(1-Qiang base-2-((1-Methylethyl) amino) Yi yl)-1, the 2-Benzenediol), Meta-proterenol (5-(1-Qiang base-2-((1-Methylethyl) amino) Yi yl)-1, the 3-Benzenediol), (4-amino-3 for Picumeterol, 5-two chloro-α-(((6-(2-(2-Bi Ding yl) ethyoxyl) hexyl)-amino) methyl) phenmethylol), (α-6-(((1 for pirbuterol (Pirbuterol), the 1-dimethyl ethyl)-amino) methyl)-3-Qiang base-2, the 6-pyridinemethanol, Procaterol (Procaterol) (((R*, S*)-(+-)-8-Qiang base-5-(1-Qiang base-2-((1-Methylethyl) amino) butyl)-2 (1H)-quinolinones (quinolin-one)), (((((2-(3 for 3-for 7-for Reproterol (Reproterol), the 5-dihydroxyphenyl)-2-Qiang Yi yl) amino)-propyl group)-3, 7-dihydro-1, 3-dimethyl-1H-Piao Ling-2, the 6-diketone), Rimiterol (Rimiterol) (4-(Qiang base-2-piperidyl methyl)-1, the 2-Benzenediol), salbutamol (Salbutamol) ((+-)-α-(((1, the 1-dimethyl ethyl) amino) methyl)-4-Qiang base-1, the 3-benzene dimethanol), (R)-salbutamol, salmeterol (Salmeterol) ((+-)-4-hydroxyl-alpha-1-(((6-(4-phenyl butoxy) hexyl)-amino) methyl)-1, the 3-benzene dimethanol), (R)-salmeterol, ((2-((1 for 5-for Terbutaline (Terbutaline), the 1-dimethyl ethyl) amino)-1-Qiang Yi yl)-1, the 3-Benzenediol), tulobuterol (Tulobuterol) (2-chloro-α-(((1, methyl) phenmethylol) and TA-2005 (8-Qiang base-5-((1R)-1-Qiang base-2-(N-((1R)-2-(4-methoxyphenyl)-1-Methylethyl) amino) Yi yl) 2-oxyquinoline hydrochloride) the 1-dimethyl ethyl).

Salbutamol sulfate, be that α uncle 1[(-butyl is amino) methyl]-4-Qiang base-meta-dimethylbenzene-α, α '-diol sulphates (2:1) (Yan), is the beta 2-adrenergic bronchodilator of relative selectivity, and its chemical formula is (C13H21NO3) 2H2SO4.

Salbutamol inhalation aerosol Yu shows can Yu anti-and alleviate 4 years old patient suffering from reversible obstructive airways disease or larger patient's bronchial spasm, and can anti-4 years old of Yu and larger patient You Yu Yun move the bronchial spasm that causes. Salbutamol inhalation solution Yu shows can alleviate 2 years old or larger patient's bronchial spasm suffering from reversible obstructive airways disease, and the acute attack that can alleviate bronchial spasm.

Zuo Xuan salbutamol hydrochloride, i.e. (R)-α 1-[[(1, the 1-dimethyl ethyl) amino] methyl]-4-Qiang base-1,3-benzene dimethanol hydrochloride, having chemical formula is C13H21NO3HCl, be the beta 2-adrenergic receptor agonist of relative selectivity, and be (the R)-enantiomer of Yao thing salbutamol. Xopenex (Zuo Xuan salbutamol hydrochloride) inhalation solution Yi single dose bottle provides, and not Xu Yao dilution before Zhi the Zai atomization. Every 3mL single dose bottle contains the husky butylamine (for the Zuo Xuan salbutamol hydrochloride of 0.73mg) of Zuo Xuan of 0.63mg or the husky butylamine of Zuo Xuan (for 1.44mg Zuo Xuan salbutamol hydrochloride) of 1.25mg, Yong sodium chloride is regulated Zhang degree (tonicity), and Yong sulfuric acid is regulated pH to 4.0 (3.3-4.5). Xopenex (Zuo Xuan salbutamol hydrochloride) inhalation solution Yu shows and can Zhi treats or the bronchial spasm of the adult patients Yi of the obstructive airways disease that Yu is anti-reversible and 12 years old and larger adolescent patient.

dopamine (D2) receptor stimulating agent includes but not limited to apomorphine (Apomorphine) ((r)-5,6,6a, 7-tetrahydrochysene-6-methyl-4H-dibenzo [de, g1 Kui Lin-10, the 11-glycol), bromocriptine (Bromocriptine) ((5 ' α)-2-Xiu-12 '-Qiang base-2 '-(1-Methylethyl)-5 '-(2-methyl-propyl) ergotamine (ergotaman)-3 ', 6 ', the 18-triketone), Cabergoline (Cabergoline) ((8-β)-N-(3-(dimethylamino) propyl group)-N-((the Yi base is amino) Tang base-1)-6-(2-acrylic) ergoline-8-formamide), lisuride (Lisuride) (N '-((8-α)-9, 10-two dehydrogenations-6-methyl ergoline-8-yl)-N, the N-diethyl urea), pergolide (Pergolide) ((8-β-)-8-((methyl mercapto) methyl)-6-pergolide), levodopa (L-Dopa (tryrosine)), Pramipexole (Pramipexole) ((s)-4, 5, 6, 7-tetrahydrochysene-N6-propyl group-2, the 6-benzothiazole diamines), Quinpirole (Quinpirole) hydrochloride (trans-(-)-4aR-4, 4a, 5, 6, 7, 8, 8a, 9-octahydro-5-propyl group-1H-Bi Zuo (pyrazolo) [3, 4-g] quinoline hydrochloride), Ropinirole (Ropinirole) (4-(2-(dipropyl is amino) Yi yl)-1, 3-dihydro-2H-Yin Duo-2-ketone) and talipexole (Talipexole) (5, 6, 7, 8-tetrahydrochysene-6-(2-acrylic)-4H-Sai Zuo [4, 5-d] azepine

-2-amine). Other Yong Yu d2 dopamine receptor activator of the present invention is disclosed in International Patent Application Publication WO 99/36095 Zhong, and it is reference that its relevant disclosure Yin enters Zuo of the present invention.

Be used for anticholinergic agents of the present invention and include but not limited to ipratropium bromide (ipratropiumbromide), oxitropium bromide, atropine methyl nitrate, atropine sulfate, Ipratropium Bromured (ipratropium), belladonna extract (belladonna extract), scopolamine (scopolamine), scopolamine Methobromide (scopolamine methobromide), melyltropeine Methobromide (homatropine methobromide), hyoscyamine, isopriopramide, orphenadrine, benzalkonium chloride, tiotropium bromide (tiotropium bromide) and glycopyrronium bromide (glycopyrronium bromide).

But other active component that is used for the composition for inhalation that the present invention describes includes but not limited to the 1L-5 inhibitor, as at United States Patent (USP) 5,668, and 110,5,683,983,5,677,280,6,071, in 910 and 5,654,276 disclosed those, they all introduce the present invention as a reference; As United States Patent (USP) 6,136, the antisense regulator of 603 disclosed IL-5 (anti-sense modulator), their relevant disclosures are introduced the present invention as a reference; Milrinone (milrinone) (1,6-dihydro-2-methyl-6-oxo-[3,4 '-two pyridine]-5-nitrile), milrinone lactate (milrinonel actate); Trypsin inhibitor, as at United States Patent (USP) 5,525, in 623 disclosed those, it is incorporated herein by reference; Tachykinin receptor antagonists, as at United States Patent (USP) 5,691, in 336,5,877,191,5,929,094,5,750,549 and 5,780,467 disclosed those, they all introduce the present invention as a reference; LTRA, as Menglusitena (montelukast sodium) (Singular, R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolyl)-vinyl]-phenyl]-3-[2-(I-hydroxyl-1-Methylethyl)-phenyl]-propyl group]-sulfo-]-methyl] cyclopropaneacetic acid (cyclopro-paneacetic acid), single sodium salt), 5-lipoxidase (Iypoxygenase) inhibitor, as zileuton (zileuton) ( , Abbott Laboratories, Abbott Park, IL) and anti--IgE antibody, as Xolair (recombinant humanized is anti--(CGP 51901 for the IgE monoclonal antibody; IGE 025A; RhuMAb-E25), Genentech, Inc., South San Francisco, CA), and local anesthetic, as lignocaine, N-aryl amide, aminoalkyl benzoate, prilocaine (prilocaine), etidocaine (etidocaine) (United States Patent (USP) 5,510,339,5,631,267 and 5,837,713, their relevant disclosure is introduced the present invention as a reference).

In some embodiments of the present invention, but described composition for inhalation be no more than with one day once give the patient.In other embodiments, but described composition for inhalation be no more than twice with one day give the patient.In some embodiments of the present invention, described compositions is surpassed twice with one day twice or one day and give the patient.In other embodiment that also has,, described composition for inhalation gives the patient at night but being no more than twice with one day.

But another aspect of the present invention relates to the composition for inhalation of the corticosteroid, solvent and the solubility enhancing agent that comprise effective dose, wherein, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but should obtain higher respirable part by composition for inhalation.In certain embodiments, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose is substantially devoid of the active medicine except that the cortex steroid.In an embodiment preferred of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least respirable part of about 10%.In a preferred embodiment of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least respirable part of about 15%.In the most preferred embodiment of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least respirable part of about 20%.

In certain embodiments, compare, but the described composition for inhalation of corticosteroid, solvent and the solubility enhancing agent of effective dose that comprises obtains to be higher than at least about 5% lung deposition with the sucked suspension that contains corticosteroid of administration under the same conditions.In other embodiments, compare, but described composition for inhalation obtains to be higher than at least about 10% lung deposition with the sucked suspension that contains corticosteroid of administration under the same conditions.In other embodiment that also has, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least about 15% lung deposition.In other embodiment that has again, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least about 20% lung deposition.In other embodiment that still has again, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least about 25% lung deposition.In certain embodiments, but the described composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose is substantially devoid of the active medicine except that the cortex steroid.

In some embodiments of the present invention, compare with the sucked suspension that contains corticosteroid, but the composition for inhalation of described corticosteroid, solvent and the solubility enhancing agent that comprises effective dose obtains approximately identical corticosteroid lung deposition when being lower than the nominal dosed administration that can suck suspension.In some embodiments of the present invention, and contain corticosteroid and can suck suspension and compare, deposit but described composition for inhalation obtains the corticosteroid lung of about 90%-110% when being lower than the nominal dosed administration that can suck suspension.In some embodiments of the present invention, and contain corticosteroid and can suck suspension and compare, deposit but described composition for inhalation obtains the corticosteroid lung of about 80%-120% when being lower than the nominal dosed administration that can suck suspension.In some embodiments of the present invention, and contain corticosteroid and can suck suspension and compare, deposit but described composition for inhalation obtains the corticosteroid lung of about 70%-130% when being lower than the nominal dosed administration that can suck suspension.In certain embodiments, but the described composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose is substantially devoid of the active medicine except that the cortex steroid.

In other embodiments of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but the described composition for inhalation of corticosteroid, solvent and the solubility enhancing agent of effective dose that comprises obtains to be higher than at least about 10% fine fraction.In the preferred embodiment of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation also obtains to be higher than at least about 15% fine fraction.In the most preferred embodiment of the present invention, compare with the sucked suspension that contains corticosteroid of administration under the same conditions, but described composition for inhalation obtains to be higher than at least about 20% fine fraction.In certain embodiments, but the described composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose is substantially devoid of the active medicine except that the cortex steroid.

In certain embodiments, compositions of the present invention can also be with pressurised metered dose inhaler (pMDI) administration.PMDI generally includes the medicine of propellant, surfactant and dissolving or suspended form.Described equipment is designed to portability, cheap, and can make the medicine lucifuge keep away oxygen to keep away wetly, can provide constant metered volume when administration.After evaporating fully, propellant can obtain undersized spraying granule.The propellant volatility of using good more (it is fast more to volatilize), the particulate size of acquisition is more little.Modal technological difficulties are medicine dissolubility in propellant.Therefore, use MDI, solubility enhancing agent of the present invention provides the method and system of administration corticosteroid, beta 2-adrenergic receptor agonist or their combination effectively.

In some embodiments of the present invention, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, has the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In some embodiments of the present invention, described nebulizer is selected from the AeroTech of PariLC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, HudsonAva-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, Hudson Iso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet 1460 and band T pipe.In some other embodiment, described nebulizer is a Pari eFlow nebulizer.

In other embodiment that also has, but composition for inhalation of the present invention can be transferred in the significantly shorter time can sucking corticosteroid treatment than routine.For example, give by Pari LC Plus blast atomizer

The nebulisation time of Respules needs at least 5 minutes-8 minutes usually, in some cases above 10 minutes.By contrast, but the described composition for inhalation that contains corticosteroid such as budesonide although be not limited to specific administration time, in preferred embodiments, can be transferred to being less than in about 1.5 minutes time of delivery being less than about 5 minutes.In some embodiments, time of delivery can be about 5 minutes.In other embodiments, time of delivery can be less than about 5 minutes.In certain embodiments, time of delivery can be about 4.5 minutes.In some other embodiment, time of delivery can be less than about 4.5 minutes.In other embodiment that also has, time of delivery can be about 4 minutes.In other embodiment that has again, time of delivery can be less than about 4 minutes.In other embodiment that still also has, time of delivery can be about 3.5 minutes.In other embodiments, time of delivery can be less than about 3.5 minutes.In other embodiment that still also has, time of delivery can be about 3 minutes.In other embodiments, time of delivery can be less than about 3 minutes.In certain embodiments, time of delivery can be about 2.5 minutes.In some other embodiment, time of delivery can be less than about 2.5 minutes.In other embodiment that also has, time of delivery can be about 2 minutes.In other embodiment that has again, time of delivery can be less than about 2 minutes.In preferred embodiments, time of delivery can be about 1.5 minutes.In a more preferred embodiment, time of delivery can be less than about 1.5 minutes.

Another aspect of the present invention relate to comprise albuterol (albuterol) but and the composition for inhalation of solubility enhancing agent, wherein, described compositions is compared with the albuterol of administration under the same conditions and is obtained enhanced lung deposition.But an aspect of of the present present invention relates to the composition for inhalation that comprises albuterol and solubility enhancing agent, and wherein, described compositions is compared with the albuterol of administration under the same conditions and obtained enhanced PK (pharmacokinetic) profile.But an aspect of of the present present invention also relates to by operation Pari eFlow nebulizer and produces fine grain method from the composition for inhalation of the albuterol that contains effective dose, and obtains the sedimentary method of enhanced lung when giving the patient.But another aspect of the present invention also relates to by operation Pari eFlow nebulizer and produces fine grain method from the composition for inhalation of the albuterol that contains effective dose, and the method that obtains enhanced PK (pharmacokinetic) profile when giving the patient.In some embodiments of the present invention, but described composition for inhalation comprises corticosteroid.

But the composition for inhalation that II. contains corticosteroid, said composition realizes reducing the increase of the concentration of corticosteroid in equipment

But another aspect of the present invention relates to the composition for inhalation that contains corticosteroid, solvent and solubility enhancing agent, wherein, when giving the experimenter with described compositions by equipment, described compositions during giving corticosteroid, realize by equipment the about 5 μ g/ml of per minute or lower in equipment the advancing the speed of concentration of corticosteroid.At some in other the embodiment, described compositions in preceding 3 minutes of administration, realize the about 5 μ g/ml of per minute or lower in equipment the advancing the speed of concentration of corticosteroid.At some in other the embodiment, described compositions in preceding 3 minutes of administration, realize the about 3.5 μ g/ml of per minute or lower in equipment the advancing the speed of concentration of corticosteroid.In certain embodiments, but described composition for inhalation contains have an appointment 500 μ g or corticosteroid still less.At some in other the embodiment, but described composition for inhalation contains have an appointment 250 μ g or corticosteroid still less.In other embodiment, but described composition for inhalation contains have an appointment 240 μ g or corticosteroid still less.In other the embodiment that also has, but described composition for inhalation contains have an appointment 120 μ g or corticosteroid still less.In other embodiment that also has, but described composition for inhalation contains have an appointment 60 μ g or corticosteroid still less.In other embodiment that also has, but described composition for inhalation contains have an appointment 40 μ g or corticosteroid still less.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but described composition for inhalation contains single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but described composition for inhalation contains budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

At some in other the embodiment, but the composition for inhalation that contains corticosteroid, solvent and solubility enhancing agent in preceding 3 minutes of administration, realize per minute about 5% or lower in equipment the advancing the speed of concentration of corticosteroid.In some embodiments, described corticosteroid is budesonide or pharmaceutically acceptable derivates.At some in other the embodiment, but described composition for inhalation contains corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.

At some in other the embodiment, but the composition for inhalation of described corticosteroid, solvent and the solubility enhancing agent that contains effective dose is when giving the experimenter by equipment with described compositions, advance the speed with the corticosteroid concentration in equipment that the sucked suspension that comprises corticosteroid that does not have solubility enhancing agent of administration is under the same conditions realized and to compare, described compositions realize about 60% or the corticosteroid concentration in equipment still less advance the speed.

In one embodiment, to advance the speed be to realize during initial 3 minutes of administration to the corticosteroid concentration in equipment.In another embodiment, it is to realize during second and the 3rd minute of administration that the corticosteroid concentration in equipment is advanced the speed.In the another embodiment that also has, it is to realize during the 3rd minute of administration that the corticosteroid concentration in equipment is advanced the speed.In certain embodiments, but the described composition for inhalation that contains corticosteroid, solvent and the solubility enhancing agent of effective dose is substantially devoid of the active medicine except that the cortex steroid.In some embodiments of the present invention, described corticosteroid is budesonide or pharmaceutically acceptable derivates.

In one embodiment, but the present invention relates to a kind of composition for inhalation, wherein give described compositions realized and can suck suspension through five minutes or less time administration and realize through five minutes or less time by described equipment.In another embodiment, but the present invention relates to a kind of composition for inhalation, wherein the time by the described compositions of described equipment administration is identical with the described administration time that sucks suspension.In other embodiment that also has, but the present invention relates to a kind of composition for inhalation, wherein the time by the described compositions of described equipment administration is different with the described administration time that sucks suspension.

In a preferred embodiment of the invention, described compositions also realizes the respirable part at least about 60% when administration.In a preferred embodiment of the present invention, described compositions also realizes the respirable part at least about 70% when administration.In preferred embodiment of the present invention, described compositions also realizes the respirable part at least about 80% when administration.In the most preferred embodiment of the present invention, described compositions also realizes the respirable part at least about 85% when administration.

In some embodiments of the present invention, but the composition for inhalation that contains corticosteroid, solvent and solubility enhancing agent contains the 15-500 μ g corticosteroid of having an appointment, and described compositions can realize in administration time that about 5 μ g/ml of per minute or the lower concentration of corticosteroid in equipment advances the speed.In other embodiments, but described composition for inhalation contains the 50-500 μ g corticosteroid of having an appointment.In other embodiment that also has, but described composition for inhalation contains the 60-250 μ g corticosteroid of having an appointment.In other embodiment that has again, described compositions contains the 125-500 μ g corticosteroid of having an appointment.In certain embodiments, but described composition for inhalation comprises the corticosteroid of about 40,60,120,125,240,250,500,1000,1500 or 2000 μ g.In one embodiment, but described composition for inhalation comprises the corticosteroid of the about 40 μ g of nominal dosage.In another embodiment, but described composition for inhalation comprises the corticosteroid of the about 60 μ g of nominal dosage.In another embodiment, but described composition for inhalation comprises the corticosteroid of the about 100 μ g of nominal dosage.In the another embodiment that has again, but described composition for inhalation comprises the corticosteroid of the about 120 μ g of nominal dosage.In the another embodiment that also has, but described composition for inhalation comprises the corticosteroid of the about 125 μ g of nominal dosage.In the another embodiment that has again, but described composition for inhalation comprises the corticosteroid of the about 240 μ g of nominal dosage.In the another embodiment that also has, but described composition for inhalation comprises the corticosteroid of nominal dosage less than about 250 μ g.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but described composition for inhalation contains single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but described composition for inhalation contains budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments, but the suitable composition for inhalation that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In other another embodiment, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

In some embodiments of the present invention, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid.In other embodiments, but the composition for inhalation that comprises corticosteroid does not comprise micelle, mixed micelle liquid or liposome liquid.In other other embodiment, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid, micelle, mixed micelle liquid or liposome liquid.In other embodiments, but composition for inhalation includes but not limited to solution, emulsion and colloidal solution.In one embodiment, but composition for inhalation is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, but composition for inhalation is the emulsion that comprises corticosteroid such as budesonide and solubility enhancing agent.

But the corticosteroid that can be used for the composition for inhalation of the present invention's description includes but not limited to aldosterone, beclometasone, betamethasone, budesonide, ciclesonide, cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, fluocinolone acetonide, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), halcinonide, hydrocortisone, Chinese mugwort cormetasone (icomethasone), prednisolone (meprednisone), Methyllprednisolone (methylprednisolone), mometasone (mometasone), paramethasone, andrographolide (prednisolone), prednisone (prednisone), rofleponide, RPR 106541, tixocortol (tixocortol), triamcinolone (triamcinolone) and they are pharmaceutically acceptable derivates separately.In preferred embodiments, described corticosteroid is a budesonide.In other embodiment preferred, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together

In certain embodiments, the system and method for the present invention's description comprises solvent.In certain embodiments, described solvent is selected from water, water/alcohol mixture, aqueous alcohol, propylene glycol or water-containing organic solvent, or its combination.In certain embodiments, described solvent comprises water.In preferred embodiments, described solvent is a water.

But in other embodiment of the composition for inhalation that the present invention describes, but described composition for inhalation comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have the concentration (w/v) of about 2%-10%.In one embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 2% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 7% concentration (w/v).In also having another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 10% concentration (w/v).

Be suitable for including but not limited to propylene glycol, non-ionic surface active agent, phospholipid, cyclodextrin and derivant thereof and surface modifier and/or stabilizing agent at the chemical agent as solubility enhancing agent of the present invention.In other embodiments, solubility enhancing agent is meant a kind of compound method that enhanced dissolubility is provided under the means that do not have chemical agent as the increase dissolubility, for example, uses the supercritical fluid preparation method to produce and is used at the dispersive nano-particle of solvent.

It is that but the solubility enhancing agent that is suitable for composition for inhalation of the present invention in addition is known in the art and be described in for example United States Patent (USP) 5,134,127,5,145,684,5,376,645,6,241,969 and U.S. Patent Application Publication 2005/0244339 and 2005/0008707 in, they all specifically introduce the present invention as a reference.In addition, the case description of suitable solubility enhancing agent is as follows.

Be suitable for that cyclodextrin of the present invention and derivant thereof be known in the art, for example, AAPS PharmSciTech such as Challa 6 (2): E329-E357 (2005), United States Patent (USP) 5,134,127,5,376,645 and 5,874,418, they all specifically introduce the present invention as a reference.In some embodiments, be suitable for cyclodextrin of the present invention and derivant thereof and include but not limited to alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, SAE-CD derivant (for example, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

With (the Cydex of SBE-γ-CD), Inc.Lenexa, KS), hydroxyethyl ether, hydroxypropyl ether (comprising 2-and 3-hydroxypropyl ether) and dihydroxypropyl ether, their corresponding compound ethers and also with the blended compound ether of the ether with methyl or ethyl, described ether with methyl or ethyl such as α-, β-and methyl hydroxyethyl ether, ethyl-hydroxyethyl ether and the ethyl-hydroxypropyl ether of gamma-cyclodextrin; And α-, β-and malt-base, glucosyl group and the maltotriose radical derivative of gamma-cyclodextrin, they can comprise one or more saccharide residues, for example glucosyl group or glucosulfone base, malt-base or two malt-bases and their various mixture, for example, the mixture of malt-base and two malt-base derivants.Be used for concrete cyclodextrin derivative of the present invention and comprise HP-; hydroxyethyl-; hydroxypropyl-gamma-cyclodextrin; ethoxy-gamma-cyclodextrin; dihydroxypropyl-beta-schardinger dextrin-; glucosyl group-alpha-cyclodextrin; the glucose group-beta-cyclodextrin; the glucosulfone group-beta-cyclodextrin; malt-base-alpha-cyclodextrin; malt sugar group-beta-cyclodextrin; malt-base-gamma-cyclodextrin; G 3-; maltotriose glycosyl-gamma-cyclodextrin; two malt sugar group-beta-cyclodextrins; DE-; glucosyl group-alpha-cyclodextrin; the glucose group-beta-cyclodextrin; the glucosulfone group-beta-cyclodextrin; three-O-methyl-beta-schardinger dextrin-; three-O-ethyl-beta-schardinger dextrin-; three-O-butyryl group-beta-cyclodextrin; three-O-valeryl group-beta-cyclodextrin and two-O-hexanoyl group-beta-cyclodextrin; and methyl-beta-schardinger dextrin-; with their mixture, as malt sugar group-beta-cyclodextrin/two malt sugar group-beta-cyclodextrins.The method for preparing these cyclodextrin derivative is known, for example can be from United States Patent (USP) 5,024, and 998 and introduce in the present invention's list of references as a reference and know.Other is suitable for cyclodextrin of the present invention and comprises the carboxyalkyl sulfide derivative, as ORG 26054 and the ORG 25969 that provides by ORGANON (AKZO-NOBEL), the hydroxy butenyl ether derivant that provides by EASTMAN, sulfoalkyl-hydroxyalkyl ether derivant, sulfoalkyl-alkyl ether derivative, with other derivant, for example U.S. Patent application 2002/0128468,2004/0106575,2004/0109888 and 2004/0063663, perhaps United States Patent (USP) 6,610,671,6,479,467,6,660,804 or 6,509,323 is described, and they all specifically introduce the present invention as a reference.

HP-can (Flanders NJ) obtains from Research Diagnostics Inc..The example of HP-comprises

(substitution value is about 4) and

(substitution value is about 8); Yet the embodiment that comprises other substitution value can also obtain and within the scope of the invention.

The dimethyl cyclodextrin can from FLUKA Chemie (Buchs, CH) or Wacker (Iowa) obtain.Other cyclodextrin that is suitable for derivatization of the present invention comprises the cyclodextrin of water miscible derivatization.The cyclodextrin of exemplary water miscible derivatization comprises carboxylated derivant, sulfated derivative, alkyl derivative, hydroxy alkylated derivant, the derivant that methylates and carboxyl-beta-schardinger dextrin-, for example, and succinyl group-beta-cyclodextrin (SCD).All these raw materials can be according to methods known in the art preparation and/or can be commercially available.The cyclodextrin of the derivatization that is fit to is disclosed in ModifiedCyclodextrins:Scaffolds and Templates for Supramolecular Chemistry (Eds.Christopher J.Easton, Stephen F.Lincoln, Imperial CollegePress, London, UK, 1999) and New Trends in Cyclodextrins andDerivatives (Ed.Dominique Duchene, Editions de Sant é, Paris, France, 1991) in.

As if be used for the example that has the non-ionic surface active agent of good especially physiological compatibility of the present invention is tyloxapol (tyloxapol), polysorbate, polysorbate includes but not limited to polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan-monopalmityl ester, polyoxyethylene (20) anhydrosorbitol monostearate (with acquisitions such as commodity Tweens 20-40-60 by name), polysorbate80, PEG400, sodium lauryl sulfate, sorbitan laurate, sorbitan palmitate, sorbitan stearate (with acquisitions such as commodity Span20-40-60 by name), benzalkonium chloride, PPO-PEO block copolymer (Pluronics), Cremophor-EL, vitamin E-TPGS (as, d-α-fertility base (tocopheryl)-Polyethylene Glycol-1000-succinate), Solutol-HS-15, oleic acid PEO ester, stearic acid PEO ester, Triton-X100, Nonidet P-40 and Polyethylene Glycol (macrogol) hydroxy stearic acid ester such as Polyethylene Glycol-15 hydroxy stearic acid ester.

In some embodiments, be suitable for the preparation of non-ionic surface active agent of the present invention and corticosteroid to form Liposomal formulation, micelle or mixed micelle.The method of preparation and characterization of liposomes and Liposomal formulation is known in the art.Usually, when amphipathic lipid can spontaneous formation multilamellar bubble during by hydration, and the formation of little monolayer bubble need relate to the method for a large amount of energy input usually, for example, and ultrasonication or high pressure homogenize.The method of other preparation and characterization of liposomes is described (Preparation and characterization of liposomes astherapeutic delivery systems:a review.Pharm Acta HeIv.1995 by people such as for example S.Vemuri, 70 (2): 95-111) and be described in United States Patent (USP) 5,019,394,5,192,228,5,882,679,6, in 656,497, they all specifically introduce the present invention as a reference.

In some cases.For example, micelle or mixed micelle can be formed by surfactant, and the relatively poor active agent of dissolubility can be dissolved in wherein.Usually, micelle is understood that the spontaneous and dynamic spheric basically structure of associating and forming by amphiphile, amphiphilic molecule such as surfactant.The micelle that mixed micelle is made of dissimilar amphiphile, amphiphilic molecules.Micelle and mixed micelle neither are interpreted as solid particle, because their structure, character and behavior and solid differ greatly.Form the temporary transient usually association of micellar amphiphile, amphiphilic molecule.In micellar solution, form micellar amphiphile and also exist in solution there to be the exchange of dynamic molecule between the dispersive amphiphile of unimolecule form.The structure and the employed surfactant of these molecules depended in the position that is dissolved in the drug molecule in this micelle or the mixed micelle.For example, suppose that nonpolar molecule particularly mainly is positioned at the inside of colloform texture, and polar substances more may be positioned at the surface.In an embodiment of micelle or mixed micelle solution, micellar mean size can be less than about 200nm (detecting with photon correlation spectroscopy (photon correlationspectroscopy)), for example about 10-100nm.Special preferred average diameter is the micelle of about 10-50nm.The method for preparing micelle and mixed micelle is known in the art, and for example is described in the United States Patent (USP) 5,747,066 and 6,906,042, and they all specifically introduce the present invention as a reference.

Phospholipid is defined as containing the amphiphilic lipids of phosphorus.Extensively exist and be generally used for medicament purpose from the chemically derived phospholipid of phosphatidic acid.This acid is generally the glycerol-3-phosphate of (two) acidylate, and wherein, fatty acid residue can have different length.The derivant of described phosphatidic acid comprises, for example, phosphocholine or phosphatidylcholine, wherein, phosphate group is also had PHOSPHATIDYL ETHANOLAMINE, phosphatidylinositols etc. by choline esterification extraly.Lecithin is the natural mixture that has the various phospholipid of a high proportion of phosphatidylcholine usually.Depend on source and the extraction and/or the enrichment method of special lecithin, these mixture also may comprise a large amount of sterin, fatty acid, triglyceride and other material.

The physiological property owing to them in addition is fit to comprise by sucking the phospholipid of carrying, especially, the mixture of phospholipids that extracts from natural origin such as Semen sojae atricolor or egg yolk with the form of lecithin, preferably with hydrogenated form and/or do not contain LYSOLECITHIN SUNLECITHIN A, and phospholipid purification, enrichment or the partial synthesis preparation, preferably have polyunsaturated fatty acid ester.In mixture of phospholipids, lecithin is particularly preferred.Medium chain described enrichment or partial synthesis preparation mainly is not contained in unsaturated on the acyl chain to the long-chain zwitterionic phospholipid, and does not contain LYSOLECITHIN SUNLECITHIN A and peroxide.The example of enrichment or purifying compounds is dimyristoyl phosphatidyl choline (DMPC), distearoyl phosphatidylcholine (DSPC) and dipalmitoyl phosphatidyl choline (DPPC).In these materials, DMPC is preferred at present.Alternatively, there is not the phospholipid of oleoyl residue and do not have the phosphatidyl glycerol of choline residue to be suitable for embodiments more of the present invention and application.

In some embodiments, be suitable for the preparation of non-ionic surface active agent of the present invention and phospholipid and corticosteroid to form colloform texture.Colloid solution is defined as single_phase system, and wherein, the colloidal materials that is dispersed in the colloid solution does not have measurable, the common physical property relevant with solid material.The method for preparing aqueous colloidal dispersion is known in the art, for example, and at United States Patent (USP) 6,653, described in 319, this patent is specifically introduced the present invention as a reference.

Be used for that suitable surface modifier of the present invention is known in the art, for example United States Patent (USP) 5,145, and 684,5,510,118,5,565,188 and 6,264,922 descriptions, they all specifically introduce the application as a reference.The example that is suitable for surface modifier of the present invention and/or surface stabilizer is including, but not limited to hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate, gel, casein, lecithin (phospholipid), glucosan, arabic gum, cholesterol, Tragacanth, stearic acid, benzalkonium chloride, calcium stearate, glyceryl monostearate, the spermol stearyl alcohol, spermol Polyethylene Glycol emulsifing wax, sorbitan esters, polyoxyethylene alkyl ether (as, polyglycol ether such as spermol cetomacrogol 1000), castor oil derivatives, the polyoxyethylene sorbitan fatty acid ester (as, commercially available Tweens ^TM, for example Tween 20 ^TMWith Tween 80 ^TM(ICI Specialty Chemicals)), Polyethylene Glycol (as, Carbowaxs 3550 ^TMWith 934 ^TM(Union Carbide)), Myrj 45, silica sol, phosphate ester, carboxymethylcellulose calcium, sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl-cellulose, Hydroxypropyl Methylcellulose Phathalate, amorphous cellulose element, aluminium-magnesium silicate, triethanolamine, polyvinyl alcohol (PVA), 4-(1,1,3,3-tetramethyl butyl)-polymer (being also referred to as tyloxapol, superione and triton) of phenol and oxirane and formaldehyde, poloxamer (poloxamers) (Pluronics F68 for example ^TMAnd F108 ^TM, they are block copolymers of oxirane and expoxy propane), (for example Tetronic 908 for poloxamines ^TM, be also referred to as Poloxamine908 ^TM, it is to add to four function block copolymers on the ethylenediamine (BASF Wyandotte Corporation, Parsippany, NJ.)), Tetronic1508 in proper order by expoxy propane and oxirane ^TM(T-1508) (BASF Wyandotte Corporation), Tritons X-200 ^TM, it is alkyl aryl polyether sulphonic acid ester (Rohm and Haas), Crodestas F-100 ^TM, it is the mixture (Croda Inc.), right-different Nonylphenoxy poly epihydric alcohol of sucrose stearate and sucrose distearate, is also referred to as Olin-IOG ^TMOr Surfactant 10 ^TM(Olin Chemicals; Stamford; Conn.); Crodestas SL-40.RTM. (Croda; Inc.) and SA9OHCO; it is C18H37CH2 (CON (CH3)-CH2 (CHOH) 4 (CH2OH) 2 (Eastman Kodak Co.); capryl-N-methyl glucose amide (glucamide); just-decyl-β-D-pyranglucoside; just-decyl-β-D-pyrans maltoside; just-dodecyl β-D-pyranglucoside; just-dodecyl β-D-maltoside; heptanoyl group-N-methyl glucose amide; just-heptyl-β-D-pyranglucoside; just-heptyl-β-D-sulfydryl glucoside; just-heptyl-β-D-pyranglucoside; pelargonyl group-N-methyl glucose amide; just-noyl-β-D-pyranglucoside; caprylyl-N-methyl glucose amide; just-octyl group-β-D-pyranglucoside; octyl group β-D-pyrans sulfydryl glucoside (thioglucopyranoside); PEG-phospholipid; the PEG-cholesterol; the PEG-cholesterol derivative; the PEG-vitamin A; the PEG-vitamin E; lysozyme; (for example, the hydroxypropyl emthylcelluloses such as random copolymer of vinyl pyrrolidone and vinyl acetate; hydroxypropyl cellulose; polyvinylpyrrolidone; vinyl acetate copolymer; vinylpyrrolidone; sodium lauryl sulfate and dioctyl sodium sulfosuccinate).

Other useful cationic stabilized agent includes but not limited to cation lipid, sulfonium, Phosphonium and quaternary ammonium compound, as stearyl trimethyl ammonium chloride, benzyl-two (2-chloro ethyl) ethyl ammonium bromide, the chlorination of cocos nucifera oil trimethyl or ammonium bromide, the dihydroxy ethyl chlorination of cocos nucifera oil methyl or ammonium bromide, decyl triethyl ammonium chloride, the ethoxy chlorination of decyl dimethyl or ammonium bromide, C _12-15Chlorination of dimethyl ethoxy or ammonium bromide, the chlorination of coco dimethyl ethoxy or ammonium bromide, myristyl trimethyl methylsulfuric acid ammonium, the chlorination of lauryl dimethyl benzyl or ammonium bromide, lauryl dimethyl (ethyleneoxy) 4 chlorinations or ammonium bromide, N-alkyl (C _12-18) dimethyl benzyl ammonium chloride, N-alkyl (C _14-18) dimethyl benzyl ammonium chloride, N-myristyl dimethyl benzyl (tetradecylidmethylbenzyl) ammonium chloride monohydrate, dimethyl dodecyl chlorination ammonium (dimethyl didecyl ammonium chloride), N-alkyl and (C _12-14) dimethyl 1-naphthyl methyl ammonium chloride, trimethyl-ammonium halide, alkyl-leptodactyline and dialkyl group-dimethyl ammonium, lauryl trimethyl ammonium chloride, alkylamide (alkyamido) the alkyl dialkyl ammonium salt of ethoxylation and/or trialkyl ammonium salts, dialkyl benzene dialkylammonium chloride, N-dodecyl (N-didecyl) alkyl dimethyl ammonium chloride, N-myristyl dimethyl benzyl ammonium chloride monohydrate, the N-alkyl (C of ethoxylation _12-14) dimethyl 1-naphthyl methyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride, dialkyl benzene alkyl ammomium chloride, lauryl trimethyl ammonium chloride, alkyl benzyl ammonio methacrylate, alkyl benzyl dimethyl ammonium bromide, C ₁₂, C ₁₅, C ₁₇Trimethylammonium bromide, dodecylbenzyl triethyl ammonium chloride, diallyl dimethyl ammoniumchloride (DADMAC), alkyl dimethyl ammonium chloride, alkyl dimethyl ammonium halide, three cetyl ammonio methacrylates, decyl trimethylammonium bromide, dodecyl triethyl group ammonium bromide, Tetradecyl Trimethyl Ammonium Bromide, (AL1QUAT 336 for methyl trioctylphosphine ammonium chloride ^TM), POLYQUAT 10 ^TM, Tetrabutylammonium bromide, benzyltrimethylammonium bromide, cholinester (as the cholinester of fatty acid), benzalkonium chloride, chlorination stearalkonium chemical compound (for example stearyl trimethyl ammonium chloride (stearyltrimonium chloride) and VARISOFT TA100 (Di-stearyldimonium chlor ide)), chlorination or cetylpyridinium bromide, quaternised polyoxy ethyl alkylamine halide salts, Mirapol ^TMAnd ALKAQUAT ^TM(AlkarilChemical Company), Fixanol; Amine, for example alkylamine, dialkylamine, alkanolamine, polyethylenepolyamine, acrylic acid N, N-dialkyl aminoalkyl ester and vinyl pyrimidine; Amine salt, as acetic acid lauryl amine, acetic acid stearylamine, Fixanol and alkyl imidazole salt, with amine oxide, acid imide azolinium salt, protonated season acrylamide, the season polymer that methylates, as poly-[diallyldimethylammonium chloride] and poly--[N-methyl ethylene pyridinium chloride] and cationic guar gum.

In certain embodiments, but composition for inhalation of the present invention comprises solubility enhancing agent, and this solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD ( ), SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In certain embodiments, described solubility enhancing agent be SBE7-β-CD ( ).

In some other embodiment, but composition for inhalation of the present invention comprises and is selected from following solubility of substances reinforcing agent: cyclodextrin and derivant thereof, SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD ( ), SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-.In some other embodiment, described solubility enhancing agent be SBE7-β-CD ( ).

But except the moisture suction mixture or composition for inhalation that comprise corticosteroid and solubility enhancing agent, the present invention expects that also moisture suction mixture or the compositions prepared by the method that enhanced dissolubility is provided are equally applicable to invention disclosed herein.Therefore, in the context of the invention, " solubility enhancing agent " is included in the moisture suction mixture that is with or without as the method preparation by enhanced dissolubility is provided under the situation of the chemical agent of solubility enhancing agent.This method comprises for example preparation of supercritical fluid.According to this method, corticosteroid composition such as budesonide manufactured have narrow particle size distribution (wide less than 200 nanometers usually), granule mean hydrodynamic radius are the granule of 50 nanometers-700 nanometer.The corticosteroid granule of nano-scale is to use the manufacturing of supercritical fluid (SCF) method as the budesonide granule, described supercritical fluid (SCF) method comprises the rapid expanding (RESS) of supercritical solution, or the solution of supercritical fluid strengthens dispersion (SEDS) and any other relates to the technology of supercritical fluid.Use the SCF method to form particulate summary and see Palakodaty, S. etc., Pharmaceutical Research 16:976-985 (1999), and be described in Bandi etc., Eur.J.Pharm.Sci.23:159-168 (2004), United States Patent (USP) 6,576,264 and U.S. Patent application 2003/0091513 in, they all specifically introduce the present invention as a reference.These methods allow to have the micron of different shape and the granule of submicron-scale according to method selected and parameter formation.In addition, these nano-particle can be made by any other conventional method that spray drying, lyophilization, volume-exclusion (volumeexclusion) and granule reduce.

And the described method for preparing nano-sized particles comprises that SCF can allow by suitably regulate the form that granuloplastic condition selects to expect (for example unformed, crystalline or split racemic) in precipitation or condensation course.Owing to select the particle form of expectation, can realize that the prolongation of the medicine selected discharges.These method for making granules are used to obtain to have high-purity, hang down surperficial imperfection, hang down the nano-particle of surface charge and low deposition rate.This particle characteristic suppresses particle bond, agglomeration, also prevents sedimentation in liquid dispersion.In addition, because method such as SCF can separate the isomer of some drugs, so this separation can help the enhanced activity of medicine, effectiveness and dosage extremely to reduce.In some cases, isomer separation also helps the side effect that reduces.According to the inventive method and system; moisture suction mixture can be to comprise that by any method SCF, spray drying, precipitation and volume-exclusion (volume exclusion) manufacture the compositions of powder type, directly make the compositions of trapping medium, wherein granulating compound thereby form dispersive preparation automatically.In some embodiments, said preparation can be final preparation.

In some embodiments of the present invention, but described composition for inhalation also can comprise second kind of therapeutic agent, and this second kind of therapeutic agent is selected from beta 2-adrenergic receptor agonist, prophylactic treatment agent and anticholinergic.In some embodiments of the present invention, described beta 2-adrenergic receptor agonist is selected from albuterol (albuterol), Levalbuterol (levalbuterol) or pharmacy acceptable derivates.

In some embodiments of the present invention, but the administration of described composition for inhalation be no more than once in one day.In other embodiments, but the administration of described composition for inhalation be no more than twice in one day.In some embodiments of the present invention, described compositions is surpassed twice one day twice or one day and give the patient.In other embodiment that also has, once give the patient at night but described composition for inhalation was no more than in one day.

In some embodiments of the present invention, described equipment is nebulizer.In certain embodiments, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, has the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In some other embodiments of the present invention, described nebulizer is selected from Pari LC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, PariLCJet, DeVilbiss Pulmo-Neb, Hudson Iso-Neb (B), Hudson T-UpdraftNeb-U-Mist, the AeroTech of Pari-Jet 1460 and band T pipe.In some other embodiment, described nebulizer is a Pari eFlow nebulizer.

But III. produce fine grain method from the composition for inhalation that contains corticosteroid, described compositions provides enhanced lung deposition

But the present invention also provides from composition for inhalation and produces fine grain method, this method comprises solvent and solubility enhancing agent is joined in the corticosteroid of effective dose, with the operation nebulizer to produce the fine grained of described compositions, wherein, when giving the experimenter with described compositions by nebulizer, described method realizes depositing in the amount of the corticosteroid in the described mixture before the administration lung at least about 20%-40%, 20%-50% or about 20%-55%, for example bronchus and alveolar.In certain embodiments, but described composition for inhalation comprises single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In some embodiments, described method can realize the lung deposition in the about 25%-45% of amount of the corticosteroid in the described mixture before the administration.In other embodiments, described method can realize the lung deposition in the about 35%-40% of amount of the corticosteroid in the described mixture before the administration.In certain embodiments, described compositions realizes in the amount of the corticosteroid in the described compositions before the administration at least about 25% lung deposition.In other embodiments, described compositions realizes in the amount of the corticosteroid in the described mixture before the administration at least about 30% lung deposition.In other embodiment that also has, described compositions realizes in the amount of the corticosteroid in the described compositions before the administration at least about 35% lung deposition.In other embodiment that has again, described compositions realizes in the amount of the corticosteroid in the described compositions before the administration at least about 40% lung deposition.In other embodiments, described compositions realizes in the amount of the corticosteroid in the described compositions before the administration at least about 45% lung deposition.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein, this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but described composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but described composition for inhalation comprises the budesonide and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In a kind of embodiment preferred, but produce fine grain method from composition for inhalation and also realize respirable part when the administration at least about 60%, in preferred embodiment of the present invention, described method also realizes the respirable part at least about 70% when administration.In also preferred embodiment of the present invention, described method also realizes the respirable part at least about 80% when administration.In the most preferred embodiment of the present invention, described method also realizes the respirable part at least about 85% when administration.

In some embodiments of the present invention, comprise a certain amount of corticosteroid but produce fine grain method from the composition for inhalation that contains corticosteroid, the amount of the corticosteroid before administration in the described compositions is about 15-2000 μ g.In other embodiments, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is the about 2000 μ g of about 250-, and described solubility enhancing agent can provide enhanced lung deposition.In other embodiment that also has, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is the about 1500 μ g of about 60-, and described solubility enhancing agent can provide enhanced lung deposition.In other embodiment that has again, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is the about 1000 μ g of about 100-, and described solubility enhancing agent can provide enhanced lung deposition.In other embodiment that also has, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is the about 1000 μ g of about 120-, and described solubility enhancing agent can provide enhanced lung deposition.In other embodiment that still also has, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is the about 500 μ g of about 125-, and described solubility enhancing agent can provide enhanced lung deposition.In certain embodiments, but the composition for inhalation that comprises corticosteroid, solvent and the solubility enhancing agent of effective dose comprises a certain amount of corticosteroid, the amount of the corticosteroid before administration in the described compositions is about 40, about 60, about 100, about 120, about 125, about 240, about 250, about 500, about 1000, about 1500 or about 2000 μ g, and described solubility enhancing agent can provide enhanced lung deposition.In one embodiment, but described composition for inhalation comprises the amount of the corticosteroid in the compositions before the administration is the corticosteroid of about 40 μ g.In another embodiment, be the corticosteroid of about 60 μ g but described composition for inhalation comprises the amount of the corticosteroid in the preceding compositions of administration.In another embodiment, be the corticosteroid of about 100 μ g but described composition for inhalation comprises the amount of the corticosteroid in the preceding compositions of administration.In the another embodiment that has again, be the corticosteroid of about 120 μ g but described composition for inhalation comprises the amount of the corticosteroid in the preceding compositions of administration.In the another embodiment that also has, be the corticosteroid of about 125 μ g but described composition for inhalation comprises the amount of the corticosteroid in the preceding compositions of administration.In the another embodiment that has again, be the corticosteroid of about 240 μ g but described composition for inhalation comprises the amount of the corticosteroid in the preceding compositions of administration.In the another embodiment that also has,, described composition for inhalation is corticosteroid less than about 250 μ g but comprising the amount of the corticosteroid in the preceding compositions of administration.In another embodiment,, described composition for inhalation is corticosteroid less than about 500 μ g but comprising the amount of the corticosteroid in the preceding compositions of administration.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but described composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but described composition for inhalation comprises budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments of the present invention, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid.In other embodiments, but the composition for inhalation that comprises corticosteroid does not comprise micelle, mixed micelle liquid or liposome liquid.In other embodiment that also has, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid, micelle, mixed micelle liquid or liposome liquid.In other embodiments, but composition for inhalation includes but not limited to solution, emulsion and colloidal solution.In one embodiment, but composition for inhalation is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, but composition for inhalation is the emulsion that comprises corticosteroid such as budesonide and solubility enhancing agent.

But the corticosteroid that is used for the composition for inhalation of the present invention's description includes but not limited to aldosterone, beclometasone, betamethasone, budesonide, ciclesonide, cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, fluocinolone acetonide, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), halcinonide, hydrocortisone, Chinese mugwort cormetasone (icomethasone), prednisolone (meprednisone), Methyllprednisolone (methylprednisolone), mometasone (mometasone), paramethasone, andrographolide (prednisolone), prednisone (prednisone), rofleponide, RPR 106541, tixocortol (tixocortol), triamcinolone (triamcinolone) and their pharmaceutically acceptable derivates separately.In preferred embodiments, described corticosteroid is a budesonide.In other embodiment preferred, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

But in some embodiments of the composition for inhalation that the present invention describes, but described composition for inhalation comprises solvent.In certain embodiments, described solvent is selected from water, aqueous alcohol, propylene glycol or water-containing organic solvent.In preferred embodiments, described solvent is a water.

But in other embodiment of the composition for inhalation that the present invention describes, but described composition for inhalation comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other other embodiment, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have the concentration (w/v) of about 2%-10%.In one embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 2% concentration (w/v).In another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 7% concentration (w/v).In also having another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 10% concentration (w/v).

In other embodiment, but the composition for inhalation that is used for the inventive method also comprises solubility enhancing agent.In certain embodiments, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD ( ), SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In preferred embodiments, described solubility enhancing agent be SBE7-β-CD ( ).

In some other embodiment, but composition for inhalation of the present invention comprises and is selected from following solubility of substances reinforcing agent: cyclodextrin and derivant thereof, SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD (

), SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-.In some other embodiment, described solubility enhancing agent be SBE7-β-CD (

).

But except the moisture suction mixture or composition for inhalation that comprise corticosteroid and solubility enhancing agent, the present invention expects that also moisture suction mixture or the compositions prepared by the method that enhanced dissolubility is provided are equally applicable to invention disclosed herein.Therefore, in the context of the invention, " solubility enhancing agent " is included in the moisture suction mixture that is with or without as the method preparation by enhanced dissolubility is provided under the situation of the chemical agent of solubility enhancing agent.This method comprises for example preparation of supercritical fluid.According to this method, corticosteroid composition such as budesonide manufactured have narrow particle size distribution (wide less than 200 nanometers usually), granule mean hydrodynamic radius are the granule of 50 nanometers-700 nanometer.The corticosteroid granule of nano-scale is to use the manufacturing of supercritical fluid (SCF) method as the budesonide granule, described supercritical fluid (SCF) method comprises the rapid expanding (RESS) of supercritical solution, or the solution of supercritical fluid strengthens dispersion (SEDS) and any other relates to the technology of supercritical fluid.Use the SCF method to form particulate summary and see Palakodaty, S. etc., Pharmaceutical Research16:976-985 (1999), and be described in Bandi etc., Eur.J.Pharm.Sci.23:159-168 (2004), United States Patent (USP) 6,576,264 and U.S. Patent application 2003/0091513 in, they all specifically introduce the present invention as a reference.

In some embodiments of the present invention, but the composition for inhalation that is used for method of the present invention also can comprise second kind of therapeutic agent, and this second kind of therapeutic agent is selected from beta 2-adrenergic receptor agonist, prophylactic treatment agent and anticholinergic.In other embodiments of the present invention, described beta 2-adrenergic receptor agonist is albuterol (albuterol), Levalbuterol (levalbuterol) or its pharmacy acceptable derivates.

In some embodiments of the present invention, but method of the present invention comprises that give patient's composition for inhalation as herein described was no more than once in one day.In other embodiments of the present invention, method of the present invention comprises and gives a day twice of patient's composition for inhalation as herein described or one day above twice.

Any known suction nebulizer all is applicable to invention described herein.The nebulizer that this nebulizer comprises the nebulizer and the involving vibrations generator of for example blast atomizer, ultrasound atomizer, pulsation film nebulizer, the vibration net that has a plurality of holes or plate and contains hydroecium (for example

Be applicable to that commercially available pneumatic injection of the present invention, ultrasonic or pulsation film nebulizer comprise

(Aerogen, San Francisco, CA), Pari LC

Pari

N and Pari (PARI Respiratory Equipment, Inc., Monterey, CA),

(Omron Healthcare, Inc, Vemon Hills, Illinois), (Profile Therapeutics Inc, Boston, MA),

(Boehringer Ingelheim Ingelheim, Germany),

(Aerogen, Inc, Mountain View, CA), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Mabismist

(Mabis Healthcare, Inc, LakeForest, Illinois)

6610 (The Lumiscope Company, Inc, EastBrunswick, New Jersey), Airsep

(AirSep Corporation, Buffalo, NY), Acorn-1 and Acorn-II (Vital Signs, Inc, Totowa, NewJersey),

(Medical Industries America, Adel, Iowa),

(Hudson Respiratory Care Incorporated, Temecula, California),

(Inter surgical Incorporated, Liverpool, NewYork),

(Professional Medical Products, Greenwood, SouthCarolina), Pulmo Aide (DeVilbiss Corp.Somerset, Pennsylvania),

(Marquest, Englewood, Colorado), Fan

(Marquest, Englewood, Colorado), MB-5 (Mefar, Bovezzo, Italy), Misty

(Baxter, Valencia, California), Salter 8900 (Salter Labs, Arvin, California),

(Medic-Aid, Sussex, UK),

(Hudson Respiratory Care; Temecula, California), Whisper

(Marquest Medical Products, Englewood, Colorado),

(AiolosMedicnnsk Teknik, Karlstad, Sweden),

(Intertech Resources, Inc., Bannockbum, Illinois),

(Unomedical Inc., McAllen, Texas),

(Respiratory care Center, Hameenlinna, Finland), AERx (Aradigm corporation, Hayward, California), LDI Nebulizer (Evit Labs, Sacramento, California) and Swirler WRadioaerosol System (AMICI, Inc., Spring City, PA).

Any of these and other known nebulizer all can be used for the moisture suction mixture of carrying the present invention to describe.In some embodiments, described nebulizer can obtain from for example Pari GmbH (Starnberg, Germany), DeVilbiss Healthcare (Heston, Middlesex, UK), Healthdyne, VitalSigns, Baxter, Allied Health Care, Invacare, Hudson, Omron, Bremed, AirSep, Luminscope, Medisana, Siemens, Aerogen, MountainMedical, Aerosol Medical Ltd. (Colchester, Essex, UK), AFP Medical (Rugby, Warwickshire, UK), Bard Ltd. (Sunderland, UK), Carri-Med Ltd. (Dorking, UK), Plaem Nuiva (Brescia, Italy), Henleys Medical Supplies (London, UK), Intersurgical (Berkshire, UK), Lifecare HospitalSupplies (Leies, UK), Medic-Aid Ltd. (West Sussex, UK), Medix Ltd. (Essex, UK), Sinclair Medical Ltd. (Surrey, UK) and many other companies.

Other nebulizer that is applicable to the method and system that the present invention describes includes but not limited to blast atomizer (randomly selling with compressor), ultrasound atomizer and other nebulizer.Be used for exemplary blast atomizer of the present invention and comprise Pari LC plus/ProNeb, Pari LC plus/ProNebTurbo, Pari LCPlus/Dura Neb 1000 ﹠amp; 2000 Pari LC plus/Walkhaler, PariLC plus/Pari Master, Pari LC Star, the portable atomiser system of Omron CompAir XL (NE-C18 and injection disposable nebulizer (JetAir Disposable nebulizer)), Omron Compare Elite compressor atomiser system (but NE-C21 and Elite Air reuse nebulizer, the Pari LC Plus or the Pari LC Star nebulizer that have Proneb Ultra compressor, Pulomo-aide, Pulmo-aide LT, Pulmo-aide Traveler, Invacare Passport, Inspiration Healthdyne 626, Pulmo-Neb Traveler, DeVilbiss 646, Whisper Jet, AcornII, Misty-Neb, Alliedaerosol, Schuco Home Care, Lexan Plasic Pocet Neb, SideStream Hand Held Neb, Mobil Mist, Up-Draft, Up-DraftII, T Up-Draft, ISO-NEB, Ava-Neb, Micro Mist and PulmoMate.

Be used for exemplary ultrasound atomizer of the present invention and comprise MicroAir, UltraAir, SiemensUltra Nebulizer 145, CompAir, Pulmosonic, Scout, 5003 Ultrasonic Neb, 5110 Ultrasonic Neb, 5004 Desk Ultrasonic Nebulizer, MystiqueUltrasonic, Lumiscope ' s Ultrasonic Nebulizer, Medisana UltrasonicNebulizer, Microstat Ultrasonic Nebulizer and Mabismist Hand HeldUltrasonic Nebulizer.Be applicable to that other nebulizer of the present invention comprises 5000Electromagnetic Neb, 5001 Electromagnetic Neb, 5002 Rotary PistonNeb, Lumineb I Piston Nebulizer 5500, Aeroneb Portable NebulizerSystem, Aerodose Inhaler and AeroEclipse Breath Actuated Nebulizer.Comprise that the vibration net with a plurality of holes or the exemplary nebulizer of plate are described in NewNebuliser Technology-Aerosol Generation by Using a Vibrating Meshor Plate with Multiple Apertures by R.Dhand, Long-Term Healthcare Strategies2003, (in July, 2003), 1-4 page or leaf and Respiratory Care, 47:1406-1416 (2002), its full content is all introduced the present invention as a reference.

Other nebulizer that is applicable to invention described herein comprises the nebulizer that comprises vibration machine and contain hydroecium.This nebulizer is commercial to be sold with Pari eFlow for example, and is described in United States Patent (USP) 6,962, and in 151,5,518,179,5,261,601 and 5,152,456, they all specifically introduce the present invention as a reference.

Parameter such as flow, nethike embrane size, aerosol suction chamber size, mask size and material, valve and power supply used in the atomizing can principle according to the present invention change, to maximize the application of they and dissimilar moisture suction mixture or dissimilar corticosteroid.

Except that above-mentioned nebulizer, aerosol apparatus also is fit to the system and method that the present invention describes, and carries the moisture suction solution that comprises corticosteroid and solubility enhancing agent.Aerosol apparatus is well known in the art, and for example is described in the United States Patent (USP) 5,954,047,6,026,808,6,095,141 and 6,527,151, and they all introduce the present invention as a reference.

In certain embodiments of the invention, described nebulizer is the nebulizer and the involving vibrations generator of blast atomizer, ultrasound atomizer, pulsation film nebulizer, the vibration net that has a plurality of holes or plate and the nebulizer that contains hydroecium.In some embodiments of the present invention, described nebulizer is selected from Pari LCJet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, HudsonAva-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, Hudson Iso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet 1460 and has the AeroTech of T-pipe.In some other embodiment, described nebulizer is Pari eFlow nebulizer.

But IV. produce fine grain method from the composition for inhalation that contains corticosteroid, this method realizes reducing the increase of the concentration of corticosteroid in equipment

But another aspect of the present invention relates to from a kind of composition for inhalation and produces fine grain method, this method comprises by forming described compositions in the corticosteroid that solvent and solubility enhancing agent is joined effective dose, with the operation nebulizer to produce the fine grained of described compositions, wherein, when giving the experimenter with described compositions by nebulizer, advance the speed with the corticosteroid concentration in equipment that the sucked suspension that comprises corticosteroid that does not have solubility enhancing agent of administration is under the same conditions realized and to compare, described compositions realize about 60% or the corticosteroid concentration in equipment still less advance the speed.In certain embodiments, but described method comprises a kind of composition for inhalation that comprises single corticosteroid, but this composition for inhalation is substantially devoid of the active medicine except that the cortex steroid.

In certain embodiments, to advance the speed be to realize during initial 3 minutes of administration to the corticosteroid concentration in equipment.In other embodiments, to advance the speed be to realize during second and the 3rd minute of administration to the corticosteroid concentration in equipment.In other embodiment that also has, it is to realize during the 3rd minute of administration that the corticosteroid concentration in equipment is advanced the speed.

In certain embodiments of the invention, but described composition for inhalation is also realized the respirable part at least about 60% when administration.In a preferred embodiment of the present invention, but described composition for inhalation is also realized the respirable part at least about 70% when administration.In also preferred embodiment of the present invention, but described composition for inhalation is also realized the respirable part at least about 80% when administration.In the most preferred embodiment of the present invention, but described composition for inhalation is also realized the respirable part at least about 85% when administration.

In some embodiments of the present invention, but described composition for inhalation contains the 15-2000 μ g corticosteroid of having an appointment.In other embodiments, described compositions contains the 50-2000 μ g corticosteroid of having an appointment.In other embodiment that also has, described compositions contains the 60-1500 μ g corticosteroid of having an appointment.In other embodiment that has again, described compositions contains the 120-1000 μ g corticosteroid of having an appointment.In other embodiment that also has, described compositions contains the 125-500 μ g corticosteroid of having an appointment.In some embodiments of the present invention, described mixture comprises the described corticosteroid of about 40,60,120,125,240,250,500,1000,1500 or 2000 μ g.In some embodiments of the present invention, described compositions comprises the described corticosteroid of the about 60-2000 μ of nominal dosage g.In one embodiment, but described composition for inhalation comprises the corticosteroid of the about 40 μ g of nominal dosage.In another embodiment, but described composition for inhalation comprises the corticosteroid of the about 60 μ g of nominal dosage.In another embodiment, but described composition for inhalation comprises the corticosteroid of the about 100 μ g of nominal dosage.In the another embodiment that has again, but described composition for inhalation comprises the corticosteroid of the about 120 μ g of nominal dosage.In the another embodiment that also has, but described composition for inhalation comprises the corticosteroid of the about 125 μ g of nominal dosage.In the another embodiment that has again, but described composition for inhalation comprises the corticosteroid of the about 240 μ g of nominal dosage.In the another embodiment that also has, but described composition for inhalation comprises the corticosteroid of nominal dosage less than about 250 μ g.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but described composition for inhalation contains single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but described composition for inhalation contains budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments, but the suitable composition for inhalation that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In the another embodiment that also has, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

But in some embodiments of the composition for inhalation that the present invention describes, but composition for inhalation comprises solvent.In certain embodiments, described solvent is selected from water, aqueous alcohol, propylene glycol or water-containing organic solvent.In preferred embodiments, described solvent is a water.

But in other embodiment of the composition for inhalation that the present invention describes, but composition for inhalation comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 2% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 7% concentration (w/v).In also having another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 10% concentration (w/v).

In other embodiments, but the composition for inhalation that is used for the inventive method also comprises solubility enhancing agent.In certain embodiments, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In preferred embodiments, described solubility enhancing agent is SBE7-β-CD

In some other embodiment, but composition for inhalation of the present invention comprises and is selected from following solubility of substances reinforcing agent: cyclodextrin and derivant thereof, SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-.In some other embodiment, described solubility enhancing agent is SBE7-β-CD

In some embodiments of the present invention, but the composition for inhalation that is used for the inventive method also comprises second kind of therapeutic agent, and this second kind of therapeutic agent is selected from beta 2-adrenergic receptor agonist, prophylactic treatment agent and anticholinergic.In other embodiments of the present invention, described beta 2-adrenergic receptor agonist is albuterol (albuterol), Levalbuterol (levalbuterol) or pharmacy acceptable derivates.

In some embodiments of the present invention, but described composition for inhalation be no more than with one day once give the patient.In other embodiments, but described composition for inhalation be no more than twice with one day give the patient.In some embodiments of the present invention, described compositions is surpassed twice with one day twice or one day and give the patient.In other embodiment that also has, once give the patient at night but described composition for inhalation was no more than with one day.

In certain embodiments of the invention, described equipment is nebulizer.In some other embodiment, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In certain embodiments of the invention, described nebulizer is selected from Pari LC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, PariLC Jet, DeVilbiss Pulmo-Neb, Hudson Iso-Neb (B), Hudson T-UpdraftNeb-U-Mist, Pari-Jet 1460 and have the AeroTech of T pipe.In some other embodiment, described nebulizer is a Pari eFlow nebulizer.

Any known nebulizer all is applicable to invention described herein.This nebulizer for example comprises blast atomizer, ultrasound atomizer, pulsation film nebulizer, (for example have nebulizer and the involving vibrations generator that the vibration in a plurality of holes net or plate are arranged and the nebulizer that contains hydroecium

).Be applicable to that commercially available pneumatic injection of the present invention, ultrasonic or pulsation film nebulizer comprise

(Aerogen, San Francisco, CA), Pari LC

Pari

N and Pari

(PARI Respiratory Equipment, Inc., Monterey, CA),

(Omron Healthcare, Inc, Vemon Hills, Illinois),

(Profile Therapeutics Inc, Boston, MA),

(Boehringer Ingelheim Ingelheim, Germany),

(Aerogen, Inc, Mountain View, CA), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Mabismist

(Mabis Healthcare, Inc, Lake Forest, Illinois), 6610, (The Lumiscope Company, Inc, EastBrunswick, New Jersey), Airsep

(AirSep Corporation, Buffalo, NY), Acorn-1 and Acorn-II (Vital Signs, Inc, Tot owa, NewJersey),

(Medical Industries America, Adel, Iowa),

(Hudson Respiratory Care Incorporated, Temecula, California), (Intersurgical Incorporated, Liverpool, NewYork),

(Professional Medical Products, Greenwood, SouthCarolina),

Pulmo Aide (DeVilbiss Corp.Somerset, Pennsylvania),

(Marquest, Englewood, Colorado), Fan

(Marquest, Englewood, Colorado), MB-5 (Mefar, Bovezzo, Italy), Misty

(Baxter, Valencia, California), Salter 8900 (Salter Labs, Arvin, California),

(Medic-Aid, Sussex, UK),

(Hudson Respiratory Care; Temecula, California), Whisper (Marquest Medical Products, Englewood, Colorado),

(Aiolos Medicnnsk Teknik, Karlstad, Sweden),

(Intertech Resources, Inc., Bannockbum, Illinois), (Unomedical Inc., McAllen, Texas),

(RespiratoryCare Center, Hameenlinna, Finland), AERx (Aradigm Corporation, ayward, California),

LDI Nebulizer (Evit Labs, Sacramento, California) and Swirler W Radioaerosol System (AMICI, Inc., SpringCity, PA).

Any of these and other known nebulizer all can be used for the moisture suction mixture of carrying the present invention to describe.In some embodiments, described nebulizer can obtain from Pari GmbH for example (Starnberg, Germany), DeVilbiss Healthcare (Heston, Middlesex, UK), Healthdyne, Vital Signs, Baxter, Allied Health Care, Invacare, Hudson, Omron, Bremed, AirSep, Luminscope, Medisana, Siemens, Aerogen, MountainMedical, Aerosol Medical Ltd. (Colchester, Essex, UK), AFP Medical (Rugby, Warwickshire, UK), Bard Ltd. (Sunderland, UK), Carri-Med Ltd. (Dorking, UK), Plaem Nuiva (Brescia, Italy), Henleys MedicalSupplies (London, UK), Intersurgical (Berkshi re, UK), LifecareHospital Supplies (Leies, UK), Medic-Aid Ltd. (West Sussex, UK), Medix Ltd. (Essex, UK), Sinclair Medical Ltd. (Surrey, UK) and many other companies.

Other nebulizer that is applicable to the method and system that the present invention describes includes but not limited to blast atomizer (randomly selling with compressor), ultrasound atomizer and other nebulizer.Be used for exemplary blast atomizer of the present invention and comprise Pari LC plus/ProNeb, Pari LC plus/ProNebTurbo, Pari LCPlus/Dura Neb 1000 ﹠amp; 2000 Pari LC plus/Walkhaler, PariLC plus/Pari Master, Pari LC Star, the portable atomiser system of Omron CompAir XL (NE-C18 and injection disposable nebulizer (JetAir Disposable nebulizer)), Omron Compare Elite compressor atomiser system (but NE-C21 and Elite Air reuse nebulizer, the Pari LC Plus or the Pari LC Star nebulizer that have Proneb Ultra compressor, Pulomo-aide, Pulmo-aide LT, Pulmo-aide Traveler, Invacare Passport, Inspiration Healthdyne 626, Pulmo-Neb Traveler, DeVilbiss 646, Whisper Jet, AcornII, Misty-Neb, Allied aerosol, Schuco Home Care, Lexan Plasic Pocet Neb, SideStream Hand Held Neb, Mobil Mist, Up-Draft, Up-DraftII, T Up-Draft, ISO-NEB, Ava-Neb, Micro Mist, and PulmoMate.

Be used for exemplary ultrasound atomizer of the present invention and comprise MicroAir, UltraAir, Siemens Ultra Nebulizer 145, CompAir, Pulmosonic, Scout, 5003Ultrasonic Neb, 5110 Ultrasonic Neb, 5004 Desk Ultrasonic Nebulizer, Mystique Ultrasonic, Lumiscope ' s Ultrasonic Nebulizer, MedisanaUltrasonic Nebulizer, Microstat Ultrasonic Nebulizer and MabismistHand Held Ultrasonic Nebulizer.Be applicable to that other nebulizer of the present invention comprises 5000Electromagnetic Neb, 5001 Electromagnetic Neb, 5002 Rotary Piston Neb, Lumineb I Piston Nebulizer 5500, Aeroneb Portable Nebulizer System, Aerodose Inhaler and AeroEclipse Breath Actuated Nebulizer.Comprise that the vibration net with a plurality of holes or the exemplary nebulizer of plate are described in NewNebuliser Technology-Aerosol Generation by Usinga Vibrating Meshor Plate with Multiple Apertures by R.Dhand, Long-Term Healthcare Strategies2003, (in July, 2003), p.1-4 with Respiratory Care, 47:1406-1416 (2002), its full content is all introduced the present invention as a reference.

VI. be used to realize the sedimentary corticosteroid intake system of enhanced lung

Another aspect of the present invention relates to the corticosteroid that is used for the delivering therapeutic effective dose system to the patient, and this system comprises: the moisture suction mixture that (a) comprises corticosteroid and solubility enhancing agent; (b) nebulizer, thus, when giving the patient with compositions by nebulizer, described system realizes that amount meter based on corticosteroid in the mixture before the administration is at least about 20%-about 40%, about 20%-is about 50%, or the lung of about 20%-about 55% deposition, for example bronchus and alveolar.In some embodiments, described system can realize based on the amount meter of corticosteroid in the mixture before the administration lung deposition at least about 25%-about 45%.In other embodiments, described system can realize based on the amount meter of corticosteroid in the mixture before the administration lung deposition of 35%-about 40% at least.In certain embodiments, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 25% lung deposition.In other embodiments, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 30% lung deposition.In other embodiment that also has, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 35% lung deposition.In other embodiment that has again, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 40% lung deposition.In other embodiment that still has, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 45% lung deposition.In other embodiment that also has, described system realizes based on the amount meter of corticosteroid in the mixture before the administration at least about 50% lung deposition.In the another embodiment that also has, described system realizes based on the amount meter of corticosteroid in the mixture before the administration lung deposition at least about 40%-about 55%.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises the budesonide and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In certain embodiments of the invention, the system that is used for the moisture suction mixture that comprises corticosteroid by described nebulizer delivering therapeutic effective dose produces the respirable part at least about 60%.In other embodiments, the system that is used for the moisture suction mixture that comprises corticosteroid by described nebulizer delivering therapeutic effective dose produces the respirable part at least about 75%.In other embodiment that also has, the system that is used for the moisture suction mixture that comprises corticosteroid by described nebulizer delivering therapeutic effective dose produces the respirable part at least about 80%.In other embodiment that has again, the system that is used for the moisture suction mixture that comprises corticosteroid by described nebulizer delivering therapeutic effective dose produces the respirable part at least about 85%.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments of the present invention, described system comprises that the amount that comprises the corticosteroid in the preceding mixture of administration is the moisture suction mixture of the about 2000 μ g corticosteroid of about 15-.In other embodiments, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the mixture before the administration for the about 2000 μ g of about 250-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1500 μ g of about 60-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1000 μ g of about 100-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1000 μ g of about 120-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 500 μ g of about 125-.In certain embodiments, to comprise the amount of the corticosteroid in the mixture before the administration be about 40, about 60, about 100, about 120, about 125, about 240, about 250, about 500, about 1000, about 1500 or the corticosteroid of about 2000 μ g to described suction mixture.In one embodiment, to comprise the amount of the corticosteroid in the mixture before the administration be the corticosteroid of about 40 μ g to described suction mixture.In another embodiment, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 60 μ g.In another embodiment, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 100 μ g.In the another embodiment that has again, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 120 μ g.In the another embodiment that also has, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 125 μ g.In the another embodiment that has again, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 240 μ g.In the another embodiment that also has, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid less than about 250 μ g.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises the budesonide and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments, the suitable moisture suction mixture that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In the another embodiment that also has, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.In some embodiments of the present invention, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid.In other embodiments, but the composition for inhalation that comprises corticosteroid does not comprise micelle, mixed micelle liquid or liposome liquid.In other embodiment that has again, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid, micelle, mixed micelle liquid or liposome liquid.In other embodiments, but composition for inhalation includes but not limited to solution, emulsion and colloidal solution.In one embodiment, but composition for inhalation is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, but composition for inhalation is the emulsion that comprises corticosteroid such as budesonide and solubility enhancing agent.

The corticosteroid that is used for the suction mixture of the present invention's description includes but not limited to aldosterone, beclometasone, betamethasone, budesonide, ciclesonide, cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, fluocinolone acetonide, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), halcinonide, hydrocortisone, Chinese mugwort cormetasone (icomethasone), prednisolone (meprednisone), Methyllprednisolone (methylprednisolone), mometasone (mometasone), paramethasone, andrographolide (prednisolone), prednisone (prednisone), rofleponide, RPR 106541, tixocortol (tixocortol), triamcinolone (triamcinolone) and their pharmaceutically acceptable derivates separately.In preferred embodiments, described corticosteroid is a budesonide.In other embodiment preferred, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In other embodiment of the suction mixture that the present invention describes, described suction mixture comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 7% concentration (w/v).In the another embodiment that also has, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 10% concentration (w/v).

In other embodiments, the suction mixture that is used for the inventive method also comprises solubility enhancing agent.In certain embodiments, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-.In certain embodiments, described solubility enhancing agent is SBE7-β-CD

But except the moisture suction mixture or composition for inhalation that comprise corticosteroid and solubility enhancing agent, the present invention expects that also moisture suction mixture or the compositions prepared by the method that enhanced dissolubility is provided are equally applicable to invention disclosed herein.Therefore, in the context of the invention, " solubility enhancing agent " is included in the moisture suction mixture that is with or without as the method preparation by enhanced dissolubility is provided under the situation of the chemical agent of solubility enhancing agent.This method comprises for example preparation of supercritical fluid.According to this method, corticosteroid composition such as budesonide manufactured have narrow particle size distribution (wide less than 200 nanometers usually), granule mean hydrodynamic radius are the granule of 50 nanometers-700 nanometer.The corticosteroid granule of nano-scale is to use the manufacturing of supercritical fluid (SCF) method as the budesonide granule, described supercritical fluid (SCF) method comprises the rapid expanding (RESS) of supercritical solution, or the solution of supercritical fluid strengthens dispersion (SEDS) and any other relates to the technology of supercritical fluid.Use the SCF method to form particulate summary and see Palakodaty, S. etc., Pharmaceutical Research 16:976-985 (1999), and be described in Bandi etc., Eur.J.Pharm.Sci.23:159-168 (2004), United States Patent (USP) 6,576,264 and U.S. Patent application 2003/0091513 in, they all specifically introduce the present invention as a reference.

In other embodiment that also has, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, have the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In some embodiments of the present invention, described nebulizer is selected from PariLC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, HudsonIso-Neb (B), Hudson T-Updraft Neb-U-Mist, the AeroTech of Pari-Jet 1460 and band T pipe.In some other embodiment, described nebulizer is a Pari eFlow nebulizer.

One aspect of the present invention relates to the corticosteroid that is used for the delivering therapeutic effective dose intake system to the patient, and this intake system comprises: the sucked aqueous mixture that (a) comprises corticosteroid and solubility enhancing agent; (b) nebulizer thus, when giving the patient, is being compared the described aqueous mixture that sucks by described nebulizer with the sucked suspension that comprises corticosteroid of administration under the same conditions, described system provides the lung deposition of enhanced corticosteroid.In a preferred embodiment of the invention, described system realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about respirable part of 10%.In the preferred embodiment of the present invention, described system realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about respirable part of 15%.In the most preferred embodiment of the present invention, described system realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about respirable part of 20%.

In the preferred embodiment of the invention, the described system that comprises the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about 5% lung deposition.In another embodiment preferred of the present invention, the described system that comprises the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about 10% lung deposition.In preferred embodiment of the present invention, the described system that comprises the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about 15% lung deposition.In another preferred embodiment of the present invention, the described system that comprises the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about 20% lung deposition.In the most preferred embodiment of the present invention, the described system that comprises the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent realizes than the sucked suspension height that comprises corticosteroid of administration under the same conditions at least about 25% lung deposition.

In some embodiments of the present invention, the described system of the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent that comprises realizes comparing approximately identical corticosteroid lung deposition with the sucked suspension that comprises corticosteroid, and wherein said compositions is to be lower than the nominal dosed administration that can suck suspension.In some embodiments of the present invention, the described system of the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent that comprises realizes that the corticosteroid lung of comparing about 90%-110% with the sucked suspension that comprises corticosteroid deposits.In some embodiments of the present invention, the described system of the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent that comprises realizes that the corticosteroid lung of comparing about 80%-120% with the sucked suspension that comprises corticosteroid deposits.In some embodiments of the present invention, the described system of the sucked aqueous mixture that comprises corticosteroid and solubility enhancing agent that comprises realizes that the corticosteroid lung of comparing about 70%-130% with the sucked suspension that comprises corticosteroid deposits.

The system that the present invention describes can be delivered to the patient in one way with the sucked aqueous mixture that comprises corticosteroid such as budesonide, solvent and solubility enhancing agent, wherein, according to good medical practice, consider the clinical condition of single patient, position and method, the plan of administration and the known other factors of doctor of obtaining employment of administration, carry active matter.In people's treatment, the system and method that the present invention describes can reduce or alleviate the related indication action site of bronchus constriction obstacle, the sucked aqueous mixture that comprises corticosteroid of treatment effective dose corticosteroid such as budesonide is kept in conveying, as budesonide solution.

In yet another aspect, the described aqueous mixture that sucks comprises corticosteroid such as budesonide, wherein sucks the method administration that aqueous mixture describes according to the present invention and is no more than (b.i.d) in one day twice described.Also having aspect another, the described aqueous mixture that sucks comprises corticosteroid such as budesonide, wherein sucks the method administration that aqueous mixture describes according to the present invention and is no more than once in one day described.In also having another embodiment, the described aqueous mixture that sucks comprises corticosteroid such as budesonide, wherein with the described aqueous mixture that sucks to be no more than once administration at night in one day.

In other embodiment that also has, system of the present invention can be at the corticosteroid that can suck corticosteroid treatment delivering therapeutic effective dose in the significantly shorter time than routine.For example, by the administration of Pari LC Plus blast atomizer The nebulisation time of Respules needs at least 5 minutes-8 minutes, in some cases above 10 minutes.By contrast, method and system of the present invention can be less than about 5 minutes-be less than the corticosteroid such as the budesonide of delivering therapeutic effective dose in about 1.5 minutes time of delivery.In some embodiments, time of delivery can be about 5 minutes.In other embodiments, time of delivery can be less than about 5 minutes.In certain embodiments, time of delivery can be about 4.5 minutes.In some other embodiment, time of delivery can be less than about 4.5 minutes.In other embodiment that also has, time of delivery can be about 4 minutes.In other embodiment that has again, time of delivery can be less than about 4 minutes.In other embodiment that still also has, time of delivery can be about 3.5 minutes.In other embodiments, time of delivery can be less than about 3.5 minutes.In other embodiment that still also has, time of delivery can be about 3 minutes.In other embodiments, time of delivery can be less than about 3 minutes.In certain embodiments, time of delivery can be about 2.5 minutes.In some other embodiment, time of delivery can be less than about 2.5 minutes.In other embodiment that also has, time of delivery can be about 2 minutes.In other embodiment that has again, time of delivery can be less than about 2 minutes.In preferred embodiments, time of delivery can be about 1.5 minutes.In a more preferred embodiment, time of delivery can be less than about 1.5 minutes.

As previously mentioned, by the administration of Pari LC Plus blast atomizer

The nebulisation time of Respules may need above 10 minutes.This long administration time is very heavy to the patient, particularly when the patient is pediatric patient.Therefore, the system or the method that can reduce by sucking the time of carrying corticosteroid can increase the compliance of patient to therapeutic scheme.By contrast, method and system of the present invention can be less than about 5 minutes-be less than the corticosteroid such as the budesonide of delivering therapeutic effective dose in about 1.5 minutes time of delivery.In some embodiments, time of delivery can be about 5 minutes.In other embodiments, time of delivery can be less than about 5 minutes.In certain embodiments, time of delivery can be about 4.5 minutes.In some other embodiment, time of delivery can be less than about 4.5 minutes.In other embodiment that also has, time of delivery can be about 4 minutes.In other embodiment that has again, time of delivery can be less than about 4 minutes.In other embodiment that still also has, time of delivery can be about 3.5 minutes.In other embodiments, time of delivery can be less than about 3.5 minutes.In other embodiment that still also has, time of delivery can be about 3 minutes.In other embodiments, time of delivery can be less than about 3 minutes.In certain embodiments, time of delivery can be about 2.5 minutes.In some other embodiment, time of delivery can be less than about 2.5 minutes.In other embodiment that also has, time of delivery can be about 2 minutes.In other embodiment that has again, time of delivery can be less than about 2 minutes.In preferred embodiments, time of delivery can be about 1.5 minutes.In a more preferred embodiment, time of delivery can be less than about 1.5 minutes.

In other embodiment that the present invention also has, the suction mixture that is used for the inventive method also comprises second kind of therapeutic agent, and this second kind of therapeutic agent is selected from beta 2-adrenergic receptor agonist, prophylactic treatment agent and anticholinergic.In other embodiments of the present invention, described beta 2-adrenergic receptor agonist is albuterol, Levalbuterol (levalbuterol) or pharmacy acceptable derivates.

Another aspect of the present invention relates to the albuterol that is used for the delivering therapeutic effective dose intake system to the patient, this intake system comprises: the moisture suction mixture that (a) comprises albuterol, (b) Pari eFlow nebulizer, thus, compare with another kind of nebulizer with the albuterol of administration under the same conditions, carry described suction mixture that the lung deposition of enhanced corticosteroid is provided by described nebulizer.A further aspect of the invention relates to the albuterol that is used for the delivering therapeutic effective dose intake system to the patient, this intake system comprises: the moisture suction mixture that (a) comprises albuterol, (b) Pari eFlow nebulizer, thus, compare with another kind of nebulizer with the albuterol of administration under the same conditions, carry described suction mixture that the PK (pharmacokinetic) profile of enhanced corticosteroid is provided by described nebulizer.In some embodiments of the present invention, the described compositions that sucks comprises corticosteroid.

VII., the corticosteroid corticosteroid intake system that concentration increases in equipment of reduction is provided

Another aspect of the present invention relates to the corticosteroid that is used for the delivering therapeutic effective dose intake system to the patient, and this intake system comprises: the moisture suction mixture that (a) comprises corticosteroid, solvent and solubility enhancing agent; (b) nebulizer, thus, when giving the patient with compositions by nebulizer, advance the speed with the corticosteroid concentration in equipment that the sucked suspension that comprises corticosteroid that does not have solubility enhancing agent of administration is under the same conditions realized and to compare, described system realize about 60% or the corticosteroid concentration in equipment still less advance the speed.In certain embodiments, described moisture suction mixture comprises single corticosteroid, and is substantially devoid of the active medicine except that the cortex steroid.

In one embodiment, but the present invention relates to a kind of composition for inhalation, wherein the administration that realizes and can suck suspension through five minutes or less time by described equipment administration composition realizes through five minutes or less time.In another embodiment, but the present invention relates to a kind of composition for inhalation, wherein the time by the described compositions of described equipment administration is identical with the described administration time that sucks suspension.In other embodiment that also has, but the present invention relates to a kind of composition for inhalation, wherein the time by the described compositions of described equipment administration is different with the described administration time that sucks suspension.

In some embodiments of the present invention, described system comprises the moisture suction mixture that comprises the about 2000 μ g corticosteroid of about 15-.In other embodiments, described suction mixture comprises the corticosteroid of the about 2000 μ g of about 50-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the about 1500 μ g of about 60-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 100-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 120-.In other embodiment that still also has, described suction mixture comprises the corticosteroid of the about 500 μ g of about 125-.In certain embodiments, described suction mixture comprises the corticosteroid of about 40,60,100,120,125,240,250,500,1000,1500 or 2000 μ g.In one embodiment, described suction mixture comprises the corticosteroid of the about 40 μ g of nominal dosage.In another embodiment, described suction mixture comprises the corticosteroid of the about 60 μ g of nominal dosage.In another embodiment, described suction mixture comprises the corticosteroid of the about 100 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 120 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of the about 125 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 240 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of nominal dosage less than about 250 μ g.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, described suction mixture comprises single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, described suction mixture comprises budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In some embodiments, the suitable moisture suction mixture that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In the another embodiment that also has, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

In some embodiment of the suction mixture that the present invention describes, described suction mixture comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

In some embodiments of the present invention, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In certain embodiments, described solubility enhancing agent is SBE7-β-CD

In some embodiments of the present invention, described compositions also comprises second kind of therapeutic agent, and this second kind of therapeutic agent is selected from beta 2-adrenergic receptor agonist, prophylactic treatment agent and anticholinergic.In some embodiments of the present invention, described beta 2-adrenergic receptor agonist is albuterol (albuterol), Levalbuterol (levalbuterol) or pharmacy acceptable derivates.

In some embodiments of the present invention, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, has the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In certain embodiments of the invention, described nebulizer is selected from PariLC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, HudsonIso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet 1460 and have the AeroTech of T pipe.In certain embodiments, described nebulizer is a Pari eFlow nebulizer.

VIII. realize the sedimentary Therapeutic Method of enhanced lung

In others of the present invention, provide the method for the corticosteroid of delivering therapeutic effective dose to the patient.In certain embodiments, the method that the present invention describes relates to treatment bronchus constriction obstacle in the patient, and comprising provides the sucked aqueous mixture that comprises corticosteroid, solvent and solubility enhancing agent and carry moisture suction mixture by sucking nebulizer.

In certain embodiments, the present invention can provide a kind of method for the treatment of bronchus constriction obstacle in the patient of needs treatment, comprise by solvent and solubility enhancing agent are added to formation mixture and operation nebulizer in a certain amount of corticosteroid, wherein when described mixture being administered to the patient by nebulizer, described method can realize that amount meter based on corticosteroid in the mixture before the administration is at least about 20%-about 40%, about 20%-about 50%, or the lung of about 20%-about 55% deposition, for example bronchus and alveolar.In some embodiments, described method can realize based on the amount meter of corticosteroid in the mixture before the administration lung deposition at least about 20%-about 35%.In other embodiments, described method can realize based on the amount meter of corticosteroid in the mixture before the administration lung deposition of 20%-about 30% at least.In certain embodiments, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 25% lung deposition.In other embodiments, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 30% lung deposition.In other embodiment that also has, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 35% lung deposition.In other embodiment that has again, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 40% lung deposition.In other embodiment that still has, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 45% lung deposition.In other embodiment that still also has, described method realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 50% lung deposition.In other embodiments, described method realizes based on the amount meter of corticosteroid in the compositions before the administration lung deposition at least about 40%-about 55%.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises the budesonide and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In other embodiments of the present invention, described method also realizes when administration at least about 60% respirable part.In the preferred embodiment of the present invention, described method also realizes the respirable part at least about 70% when administration.In the embodiment that the present invention is more preferably, described method also realizes the respirable part at least about 80% when administration.In the most preferred embodiment of the present invention, described method also realizes the respirable part at least about 85% when administration.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises the single corticosteroid and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises the budesonide and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In certain embodiments, the Therapeutic Method of bronchus constriction obstacle comprises that conveying comprises the sucked aqueous mixture of corticosteroid.Be used for corticosteroid of the present invention and include but not limited to aldosterone, beclometasone, betamethasone, budesonide, ciclesonide, cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, fluocinolone acetonide, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), halcinonide, hydrocortisone, Chinese mugwort cormetasone (icomethasone), prednisolone (meprednisone), Methyllprednisolone (methylprednisolone), mometasone (mometasone), paramethasone, andrographolide (prednisolone), prednisone (prednisone), rofleponide, RPR 106541, tixocortol (tixocortol), triamcinolone (triamcinolone) and their pharmaceutically acceptable derivates separately.In some embodiments, described corticosteroid is a budesonide.In other embodiments, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In some embodiments of the present invention, described Therapeutic Method comprises that the amount that comprises the corticosteroid in the preceding mixture of administration is the moisture suction mixture of the about 2000 μ g corticosteroid of about 15-.In other embodiments, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the mixture before the administration for the about 2000 μ g of about 250-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1500 μ g of about 60-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1000 μ g of about 100-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 1000 μ g of about 120-.In other embodiment that still also has, described suction mixture comprises the corticosteroid of the amount of the corticosteroid in the preceding mixture of administration for the about 500 μ g of about 125-.In certain embodiments, to comprise the amount of the corticosteroid in the mixture before the administration be about 40, about 60, about 100, about 120, about 125, about 240, about 250, about 500, about 1000, about 1500 or the corticosteroid of about 2000 μ g to described suction mixture.In one embodiment, to comprise the amount of the corticosteroid in the mixture before the administration be the corticosteroid of about 40 μ g to described suction mixture.In another embodiment, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 60 μ g.In the another embodiment that also has, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 100 μ g.In the another embodiment that has again, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 120 μ g.In the another embodiment that still also has, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 125 μ g.In the another embodiment that has again, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid of about 240 μ g.In the another embodiment that also has, the amount that described suction mixture comprises the corticosteroid in the preceding mixture of administration is the corticosteroid less than about 250 μ g.In one embodiment, described corticosteroid is a budesonide.In another embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In certain embodiments, but composition for inhalation comprises single corticosteroid, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiment that also has, but composition for inhalation comprises budesonide, solvent and the solubility enhancing agent of effective dose, and is substantially devoid of the active medicine except that budesonide.

In certain embodiments, describedly suck budesonide, solvent and the solubility enhancing agent that mixture can comprise about 40 μ g, wherein when by nebulizer described compositions being administered to the patient, described compositions realizes the lung deposition of the budesonide of at least 13 μ g.In some other embodiment, describedly suck budesonide, solvent and the solubility enhancing agent that mixture can comprise about 60 μ g, wherein when by nebulizer described compositions being administered to the patient, described compositions realizes the lung deposition of the budesonide of at least 20 μ g.In other embodiment that also has, but described composition for inhalation can comprise budesonide, solvent and the solubility enhancing agent of about 120 μ g, wherein when by nebulizer described compositions being administered to the patient, described compositions realizes the lung deposition of the budesonide of at least 40 μ g.In other embodiment that has again, but described composition for inhalation can comprise budesonide, solvent and the solubility enhancing agent of about 240 μ g, wherein when by nebulizer described compositions being administered to the patient, described compositions realizes the lung deposition of the budesonide of at least 80 μ g.

In certain embodiments, describedly suck budesonide, solvent and the solubility enhancing agent that mixture can comprise about 40 μ g, wherein when described compositions being administered to the patient by nebulizer, described compositions realizes the lung deposition of the budesonide of at least 13 μ g, and wherein said compositions is substantially devoid of the active medicine except that budesonide.In some other embodiment, describedly suck budesonide, solvent and the solubility enhancing agent that mixture can comprise about 60 μ g, wherein when described compositions being administered to the patient by nebulizer, described compositions realizes the lung deposition of the budesonide of at least 20 μ g, and wherein said compositions is substantially devoid of the active medicine except that budesonide.In other embodiment that also has, but described composition for inhalation can comprise budesonide, solvent and the solubility enhancing agent of about 120 μ g, wherein when described compositions being administered to the patient by nebulizer, described compositions realizes the lung deposition of the budesonide of at least 40 μ g, and wherein said compositions is substantially devoid of the active medicine except that budesonide.In other embodiment that has again, but described composition for inhalation can comprise budesonide, solvent and the solubility enhancing agent of about 240 μ g, wherein when described compositions being administered to the patient by nebulizer, described compositions realizes the lung deposition of the budesonide of at least 80 μ g, and wherein said compositions is substantially devoid of the active medicine except that budesonide.

In some embodiments of the present invention, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid.In other embodiments, but the composition for inhalation that comprises corticosteroid does not comprise micelle, mixed micelle liquid or liposome liquid.In other embodiment that also has, but the composition for inhalation that comprises corticosteroid does not comprise Nanodispersion and/or nanometer suspension liquid, micelle, mixed micelle liquid or liposome liquid.In other embodiments, but composition for inhalation includes but not limited to solution, emulsion and colloidal solution.In one embodiment, but composition for inhalation is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, but composition for inhalation is the emulsion that comprises corticosteroid such as budesonide and solubility enhancing agent.In certain embodiments, the system and method for the present invention's description comprises solvent.In certain embodiments, described solvent is selected from water, water/alcohol mixture, aqueous alcohol, propylene glycol or water-containing organic solvent, or its combination.In certain embodiments, described solvent comprises water.In preferred embodiments, described solvent is a water.

In some embodiments, the Therapeutic Method of described bronchus constriction obstacle comprises that conveying comprises the sucked aqueous mixture of corticosteroid and solvent.In certain embodiments, described solvent is selected from water, aqueous alcohol, propylene glycol or water-containing organic solvent.In preferred embodiments, described solvent is a water.

In some embodiment of the suction mixture that the present invention describes, described suction mixture comprises solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have the concentration (w/v) of about 2%-10%.In one embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 2% concentration (w/v).In another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 7% concentration (w/v).In also having another embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD ( ) time, described solubility enhancing agent can have about 10% concentration (w/v).

In some embodiments of the present invention, the Therapeutic Method of described bronchus constriction obstacle comprises that conveying comprises the sucked aqueous mixture of corticosteroid and solubility enhancing agent.In certain embodiments, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In other embodiments, described solubility enhancing agent is SBE7-β-CD

In certain embodiments of the invention, described bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In some embodiments of the present invention, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, has the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In some embodiments of the present invention, described nebulizer is selected from PariLC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, HudsonIso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet 1460 and have the AeroTech of T pipe.In certain embodiments, described nebulizer is a Pari eFlow nebulizer.

In other embodiment that also has, the present invention can provide a kind of method for the treatment of bronchus constriction obstacle in the patient, comprise that providing a kind of comprises the sucked aqueous mixture of corticosteroid, solvent and solubility enhancing agent and carry moisture suction mixture by sucking nebulizer, the conveying that wherein can suck aqueous mixture makes the corticosteroid that is no more than about 10%-30% for example be transferred in oral cavity, esophagus and/or stomach outside lung.In one embodiment, described method can provide the conveying that can suck aqueous mixture, wherein is no more than about 10% corticosteroid and is transferred outside lung.In another embodiment, described method can provide the conveying that can suck aqueous mixture, wherein is no more than about 15% corticosteroid and is transferred outside lung.In also having another embodiment, described method can provide the conveying that can suck aqueous mixture, wherein is no more than about 20% corticosteroid and is transferred outside lung.Having again in the another embodiment, described method can provide the conveying that can suck aqueous mixture, wherein is no more than about 25% corticosteroid and is transferred outside lung.In also having another embodiment, described method can provide the conveying that can suck aqueous mixture, wherein is no more than about 30% corticosteroid and is transferred outside lung.

In other embodiments, the present invention can provide a kind of method of preventing bronchus constriction obstacle in the patient, comprises that providing a kind of comprises the sucked aqueous mixture of corticosteroid, solvent and solubility enhancing agent and carry moisture suction mixture by sucking nebulizer.In another embodiment, the present invention can provide a kind of method that sucks the relevant side effect risk of treatment with corticosteroid that reduces, thus, compare, need the corticosteroid of lower nominal dosage to realize therapeutic effect with the corticosteroid treatment that routine can suck.In one embodiment, compare with the corticosteroid treatment that routine can suck, the risk of side effect is lowered.

IX., the corticosteroid Therapeutic Method that concentration increases in equipment of reduction is provided

Another aspect of the present invention relates to a kind of method for the treatment of bronchus constriction obstacle in the patient of needs treatment, comprise by solvent and solubility enhancing agent are added to a kind of compositions of formation and operation nebulizer in the corticosteroid, wherein when described compositions being administered to the patient by nebulizer, advance the speed with the corticosteroid concentration in equipment that the sucked suspension that comprises corticosteroid that does not have solubility enhancing agent of administration is under the same conditions realized and to compare, described compositions realize about 60% or the corticosteroid concentration in equipment still less advance the speed.In certain embodiments, described compositions comprises single corticosteroid, and is substantially devoid of the active medicine except that the cortex steroid.In other embodiments of the present invention, described corticosteroid is budesonide or pharmaceutically acceptable derivates.In other embodiment that also has, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In certain embodiments of the invention, but described composition for inhalation is also realized the respirable part at least about 60% when administration.In an embodiment preferred of the present invention, but described composition for inhalation is also realized the respirable part at least about 70% when administration.In preferred embodiment of the present invention, but described composition for inhalation is also realized the respirable part at least about 80% when administration.In the most preferred embodiment of the present invention, but described composition for inhalation is also realized the respirable part at least about 85% when administration.

In some embodiments of the present invention, described system comprises the moisture suction mixture that comprises the about 2000 μ g corticosteroid of about 15-.In other embodiments, described suction mixture comprises the corticosteroid of the about 2000 μ g of about 50-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the about 1500 μ g of about 60-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 100-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 120-.In other embodiment that still also has, described suction mixture comprises the corticosteroid of the about 500 μ g of about 125-.In certain embodiments, described suction mixture comprises the corticosteroid of about 40,60,100,120,125,240,250,500,1000,1500 or 2000 μ g.In one embodiment, described suction mixture comprises the corticosteroid of the about 40 μ g of nominal dosage.In another embodiment, described suction mixture comprises the corticosteroid of the about 60 μ g of nominal dosage.In another embodiment, described suction mixture comprises the corticosteroid of the about 100 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 120 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of the about 125 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 240 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of nominal dosage less than about 250 μ g.In other embodiments of the present invention, described corticosteroid is budesonide or pharmaceutically acceptable derivates.In other embodiment preferred, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In some embodiments, the suitable moisture suction mixture that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In also having another embodiment, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

The time, described solubility enhancing agent can have about 2% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 5% concentration (w/v).In another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 7% concentration (w/v).In also having another embodiment, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have about 10% concentration (w/v).

In some other embodiment, but composition for inhalation of the present invention comprises and is selected from following solubility of substances reinforcing agent: cyclodextrin and derivant thereof, SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-.In some other embodiment, described solubility enhancing agent is SBE7-β-CD

But the preparation method of the present invention's composition for inhalation X.

But another aspect of the present invention relates to corticosteroid and is used for purposes in the composition for inhalation of patient's treatment of needs treatments or prevention bronchus constriction obstacle in preparation, comprise solvent and solubility enhancing agent are added to a certain amount of corticosteroid neutralization operation nebulizer that wherein said compositions realizes based on the amount meter of corticosteroid in the compositions before the administration at least about 25% lung deposition.In some embodiments of the present invention, described compositions also realizes the respirable part at least about 60% when administration.In certain embodiments, but described composition for inhalation comprises single corticosteroid, solvent and solubility enhancing agent, and is substantially devoid of the active medicine except that the cortex steroid.In some embodiments, described corticosteroid is a budesonide.In other embodiments, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

But one aspect of the present invention also relates to corticosteroid and is used for purposes in the composition for inhalation at patient's treatment bronchus constriction obstacle of needs treatments in preparation, comprise solvent and solubility enhancing agent are added to a certain amount of corticosteroid neutralization operation nebulizer, the sucked suspension height that comprises corticosteroid of wherein said compositions realization ratio administration under the same conditions deposits at least about 5% lung, with the described corticosteroid of delivering therapeutic effective dose.In certain embodiments, but described composition for inhalation comprises single corticosteroid, solvent and solubility enhancing agent, and is substantially devoid of the active medicine except that the cortex steroid.

But one aspect of the present invention also relates to corticosteroid and is used for purposes in the composition for inhalation at patient's treatment bronchus constriction obstacle of needs treatments in preparation, comprise solvent and solubility enhancing agent are added to a certain amount of corticosteroid neutralization operation nebulizer, wherein, compare with the sucked suspension that comprises corticosteroid, described compositions realizes approximately identical lung deposition, wherein, with described compositions to be lower than the described nominal dosed administration that sucks suspension, with the described corticosteroid of delivering therapeutic effective dose.In certain embodiments, but described composition for inhalation comprises single corticosteroid, solvent and solubility enhancing agent, and is substantially devoid of the active medicine except that the cortex steroid.

In some embodiments of the present invention, described system comprises the moisture suction mixture that comprises the about 2000 μ g corticosteroid of about 15-.In other embodiments, described suction mixture comprises the corticosteroid of the about 2000 μ g of about 50-.In other embodiment that also has, described suction mixture comprises the corticosteroid of the about 1500 μ g of about 60-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 100-.In other embodiment that has again, described suction mixture comprises the corticosteroid of the about 1000 μ g of about 120-.In other embodiment that still also has, described suction mixture comprises the corticosteroid of the about 500 μ g of about 125-.In certain embodiments, described suction mixture comprises the corticosteroid of about 40,60,100,120,125,240,250,500,1000,1500 or 2000 μ g.In one embodiment, described suction mixture comprises the corticosteroid of the about 40 μ g of nominal dosage.In another embodiment, described suction mixture comprises the corticosteroid of the about 60 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of the about 100 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 120 μ g of nominal dosage.In the another embodiment that still also has, described suction mixture comprises the corticosteroid of the about 125 μ g of nominal dosage.In the another embodiment that has again, described suction mixture comprises the corticosteroid of the about 240 μ g of nominal dosage.In the another embodiment that also has, described suction mixture comprises the corticosteroid of nominal dosage less than about 250 μ g.In other embodiments of the present invention, described corticosteroid is budesonide or pharmaceutically acceptable derivates.In other embodiment preferred, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In some embodiments of the present invention, described solubility enhancing agent is a chemical agent, and this chemical agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD ( ), SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG26054, ORG25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In certain embodiments, described solubility enhancing agent be SBE7-β-CD (

In some embodiments of the present invention, described nebulizer is blast atomizer, ultrasound atomizer, pulsation film nebulizer, has the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.In some embodiments of the present invention, described nebulizer is selected from PariLC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, Pari LC Jet, DeVilbiss Pulmo-Neb, HudsonIso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet 1460 and have the AeroTech of T pipe.In some other embodiment, described nebulizer is a Pari eFlow nebulizer.

In some embodiments of the present invention, described bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis and emphysema.

In yet another aspect, but described composition for inhalation comprises corticosteroid such as budesonide, but the method administration of wherein described composition for inhalation being described according to the present invention was no more than (b.i.d) in one day twice.Also having aspect another, but described composition for inhalation comprises corticosteroid such as budesonide, but the method administration of wherein described composition for inhalation being described according to the present invention was no more than once in one day.In also having another embodiment, but described composition for inhalation comprises corticosteroid such as budesonide, but wherein with described composition for inhalation to be no more than once administration at night in one day.

XI. the Therapeutic Method that has enhanced pK characteristic (profiles)

Described herein being used for can provide than giving the corticosteroid enhanced PK (pharmacokinetic) profile of corticosteroid to carrying by sucking with form of suspension at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle.In preferred embodiments, the local bioavailability that is used for can realizing at the method and system of patient treatment that needs are arranged or prevention bronchus constriction obstacle the corticosteroid of the conveying that the suction treatment than routine increases described herein, this method and system especially also provides the method that obtains the needed dosage of topical therapeutic effect that is reduced to.Similarly, the method and system that is used for the treatment of bronchus constriction obstacle such as asthma is provided, this method and system can be carried to have than by sucking the corticosteroid of the enhanced PK (pharmacokinetic) profile of corticosteroid that gives with form of suspension, wherein, the method and system administration of describing by the present invention provides one or more following advantages: the local bioavailability that increases the corticosteroid of being carried; Reduce the method for the nominal dosage that the needed corticosteroid of topical therapeutic effect is provided; Reduce the method for the corticosteroid required time that gives effective dose; Increase the patient to comprising the method for the therapeutic scheme compliance that sucks the corticosteroid that atomizes; Strengthen the method that corticosteroid is carried; Increase corticosteroid in pulmonary's method of sedimentary amount in bronchus and the bubble for example; With the method that reduces the side effect relevant with sucking corticosteroid.

In some embodiments, be used for to be provided for the method for treatment bronchus constriction obstacle in the patient at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, this method comprises provides the moisture suction mixture that contains corticosteroid and solubility enhancing agent, with carry described moisture suction mixture with the suction nebulizer, wherein, corticosteroid is to be less than the nominal dosed administration of about 250 μ g/ dosage.In one embodiment, corticosteroid can be to be less than the nominal dosed administration of about 240 μ g/ dosage.In another embodiment, corticosteroid can be to be less than the nominal dosed administration of about 200 μ g/ dosage.In the another embodiment that has again, corticosteroid can be to be less than the nominal dosed administration of about 150 μ g/ dosage.In the another embodiment that also has, corticosteroid can be to be less than the nominal dosed administration of about 125 μ g/ dosage.In another embodiment, corticosteroid can be with the nominal dosed administration of about 120 μ g/ dosage.In the another embodiment that still also has, corticosteroid can be with the nominal dosed administration of about 100 μ g/ dosage.In the another embodiment that has again, corticosteroid can be with the nominal dosed administration of about 60 μ g/ dosage.In the another embodiment that still also has, corticosteroid can be with the nominal dosed administration of about 50 μ g/ dosage.In the another embodiment that also has, corticosteroid can be with the nominal dosed administration of about 40 μ g/ dosage.In some other embodiment of methods described herein, described moisture suction mixture can comprise that nominal dosage is about 15 μ g/ dosage-250 μ g/ dosage, perhaps about 40 μ g/ dosage-250 μ g/ dosage, perhaps about 60 μ g/ dosage-250 μ g/ dosage, perhaps about 40 μ g/ dosage-200 μ g/ dosage, perhaps about 60 μ g/ dosage-200 μ g/ dosage, perhaps about 40 μ g/ dosage-150 μ g/ dosage, perhaps about 60 μ g/ dosage-150 μ g/ dosage, perhaps about 40 μ g/ dosage-125 μ g/ dosage, perhaps about 60 μ g/ dosage-125 μ g/ dosage, perhaps about 40 μ g/ dosage-100 μ g/ dosage, perhaps about 60 μ g/ dosage-100 μ g/ dosage, perhaps about 25 μ g/ dosage-50 μ g/ dosage, the corticosteroid of perhaps about 25 μ g/ dosage-60 μ g/ dosage.In some embodiments, described corticosteroid is a budesonide.In other embodiments, described corticosteroid is a budesonide, and wherein, this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In other embodiment, be used for to be provided for the method for treatment bronchus constriction obstacle in the patient at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, this method comprises provides the moisture suction mixture that contains single corticosteroid and solubility enhancing agent, with carry described moisture suction mixture with the suction nebulizer, wherein, corticosteroid is gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture that are less than about 250 μ g/ dosage.In one embodiment, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture that are less than about 240 μ g/ dosage.In another embodiment, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture that are less than about 200 μ g/ dosage.In the another embodiment that has again, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture that are less than about 150 μ g/ dosage.In the another embodiment that also has, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture that are less than about 125 μ g/ dosage.In another embodiment, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture of about 120 μ g/ dosage.In the another embodiment that still also has, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture of about 100 μ g/ dosage.In the another embodiment that has again, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture of about 60 μ g/ dosage.In the another embodiment that still also has, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture of about 50 μ g/ dosage.In another embodiment, corticosteroid can be gone up the active medicine that does not contain except that described corticosteroid substantially with the nominal dosed administration and the described suction mixture of about 40 μ g/ dosage.In some other embodiment of methods described herein, described moisture suction mixture can comprise that nominal dosage is about 15 μ g/ dosage-250 μ g/ dosage, perhaps about 40 μ g/ dosage-250 μ g/ dosage, perhaps about 60 μ g/ dosage-250 μ g/ dosage, perhaps about 40 μ g/ dosage-200 μ g/ dosage, perhaps about 60 μ g/ dosage-200 μ g/ dosage, perhaps about 40 μ g/ dosage-150 μ g/ dosage, perhaps about 60 μ g/ dosage-150 μ g/ dosage, perhaps about 40 μ g/ dosage-125 μ g/ dosage, perhaps about 60 μ g/ dosage-125 μ g/ dosage, perhaps about 40 μ g/ dosage-100 μ g/ dosage, perhaps about 60 μ g/ dosage-100 μ g/ dosage, perhaps about 25 μ g/ dosage-50 μ g/ dosage, the corticosteroid of perhaps about 25 μ g/ dosage-60 μ g/ dosage, and wherein said suction mixture is gone up the active medicine that does not contain except that described corticosteroid substantially.In some embodiments, described corticosteroid is a budesonide.In other embodiments, described corticosteroid is a budesonide, and wherein, this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

In other embodiment that also has, the method and system that the present invention describes provides the conveying of the moisture suction mixture that contains corticosteroid, solvent and solubility enhancing agent, wherein, the conveying of described corticosteroid provides than carrying the enhanced PK (pharmacokinetic) profile of corticosteroid by the treatment that can suck suspension based on routine.In some embodiments, described corticosteroid is a budesonide.In other embodiment, described corticosteroid is a budesonide, and wherein, this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.

But the corticosteroid that is used for the composition for inhalation of the present invention's description includes but not limited to aldosterone, beclometasone, betamethasone, budesonide, ciclesonide, cloprednol, cortisone, cortivazol, deoxycorticosterone, desonide, desoximetasone, dexamethasone, diflucortolone (difluorocortolone), fluclorolone, fluorine first pine, flunisolide, fluocinolone, fluocinolone acetonide, fluocortin butyl, the fluorine cortisone, fluocortolone (fluorocortolone), Cortilet (fluorometholone), fluorine dihydro corticosterone (flurandrenolone), fluticasone (fluticasone), halcinonide, hydrocortisone, Chinese mugwort cormetasone (icomethasone), prednisolone (meprednisone), Methyllprednisolone (methylprednisolone), mometasone (mometasone), paramethasone, andrographolide (prednisolone), prednisone (prednisone), rofleponide, RPR 106541, tixocortol (tixocortol), triamcinolone (triamcinolone) and their pharmaceutically acceptable derivates separately.In some embodiments, described corticosteroid is a budesonide.In other embodiment, described corticosteroid is a budesonide, and wherein this budesonide is independent diastereomer or the mixture that is administered for two kinds of diastereomers of therapeutic effect separately or together.In other the embodiment, described corticosteroid is selected from the corticosteroid in the above-mentioned paragraph at some, but does not comprise betamethasone.

In another embodiment, the present invention can provide a kind of method that sucks the risk of the relevant side effect of treatment with corticosteroid that reduces, thus, compare, need the corticosteroid of low nominal dosage to realize therapeutic effect with the corticosteroid treatment that routine can suck.In one embodiment, compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 250 μ g/ dosage.In another embodiment, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 240 μ g/ dosage.In the another embodiment that also has, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 200 μ g/ dosage.In the another embodiment that has again, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 150 μ g/ dosage.In the another embodiment that has again, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 125 μ g/ dosage.In the another embodiment that still also has, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 100 μ g/ dosage.In the another embodiment that also has, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 60 μ g/ dosage.In the another embodiment that also has again, to compare with the corticosteroid treatment that routine can suck, the risk of side effect reduces, and wherein corticosteroid is to be less than the nominal dosed administration of about 50 μ g/ dosage.In some embodiments, corticosteroid is the budesonide with the nominal dosed administration that is less than about 250 μ g/ dosage.In other embodiments, corticosteroid is the budesonide with the nominal dosed administration that is less than about 125 μ g/ dosage.In other embodiment that also has, corticosteroid is with the budesonide less than the nominal dosed administration of about 120 μ g/ dosage.In other embodiment that has again, corticosteroid is with the budesonide less than the nominal dosed administration of about 60 μ g/ dosage.In other embodiment that still also has, corticosteroid is with the budesonide less than the nominal dosed administration of about 40 μ g/ dosage.

System and method as herein described provides the conveying of the moisture suction mixture that comprises corticosteroid and solubility enhancing agent.In some embodiments, the suitable moisture suction mixture that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In the another embodiment that also has, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

System and method as herein described provides the conveying of the moisture suction mixture that comprises corticosteroid, solvent and solubility enhancing agent.In some embodiments, the suitable moisture suction mixture that comprises corticosteroid includes but not limited to solution, dispersion, Nanodispersion, emulsion, colloidal solution, micelle or mixed micelle solution and liposome liquid.In one embodiment, described moisture suction mixture is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In another embodiment, described moisture suction mixture is the mixed micelle solution that comprises corticosteroid such as budesonide and solubility enhancing agent.In the another embodiment that also has, described moisture suction mixture is the liposome solutions that comprises corticosteroid such as budesonide and solubility enhancing agent.

In certain embodiments, the system and method for the present invention's description comprises solvent.In certain embodiments, described solvent is selected from water, water/alcohol mixture, aqueous alcohol, propylene glycol, or water-containing organic solvent, or their combination.In certain embodiments, described solvent comprises water.In preferred embodiments, described solvent is a water.

In some embodiments of the system and method that the present invention describes, use the moisture suction mixture that contains corticosteroid, this mixture also contains solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD The time, described solubility enhancing agent can have the concentration (w/v) of about 2%-10%.In one embodiment, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

The time, described solubility enhancing agent can have about 7% concentration (w/v).In the another embodiment that also has, when described solubility enhancing agent is cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

Be suitable for the chemical agent as solubility enhancing agent of the present invention and include but not limited to propylene glycol, non-ionic surface active agent, phospholipid, cyclodextrin and derivant thereof, surface modifier and/or stabilizing agent.In other embodiments, solubility enhancing agent is meant provides the formulation method that strengthens dissolubility under the chemical agent that does not work the means effect that increases dissolubility, for example, uses the supercritical fluid preparation method to produce and is used at the dispersive nano-particle of solvent.

That other solubility enhancing agent is known in the art and be described in United States Patent (USP) 5,134,127,5,145,684,5,376,645 and 6,241,969 and U.S. Patent Application Publication 2005/0244339 and 2005/0008707 in, they all specifically introduce the present invention as a reference.In addition, the case description of suitable solubility enhancing agent is as follows.

This area has been described and has been suitable for cyclodextrin of the present invention and derivant thereof, for example, Challa etc., AAPS PharmSciTech 6 (2): E329-E357 (2005), United States Patent (USP) 5,134,127,5,376,645 and 5,874,418, they all specifically introduce the present invention as a reference.In some embodiments, be suitable for cyclodextrin of the present invention or cyclodextrin derivative and include but not limited to alpha-cyclodextrin, beta-schardinger dextrin-, gamma-cyclodextrin, SAE-CD derivant (for example, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD With (the Cydex of SBE-γ-CD), Inc.Lenexa, KS), hydroxyethyl ether, hydroxypropyl ether (comprising 2-and 3-hydroxypropyl ether) and dihydroxypropyl ether, their corresponding compound ethers and also with the blended compound ether of the ether with methyl or ethyl, described ether with methyl or ethyl such as α-, β-and methyl hydroxyethyl ether, ethyl hydroxyethyl ether and the ethyl hydroxypropyl ether of gamma-cyclodextrin; And α-, β-and malt-base, glucosyl group and the maltotriose radical derivative of gamma-cyclodextrin, they can comprise one or more saccharide residues, for example glucosyl group or glucosulfone base, malt-base or two malt-bases and their various mixture, for example, the mixture of malt-base and two malt-base derivants.Be used for concrete cyclodextrin derivative of the present invention and comprise HP-; hydroxyethyl-; hydroxypropyl-gamma-cyclodextrin; ethoxy-gamma-cyclodextrin; dihydroxypropyl-beta-schardinger dextrin-; glucosyl group-alpha-cyclodextrin; the glucose group-beta-cyclodextrin; the glucosulfone group-beta-cyclodextrin; malt-base-alpha-cyclodextrin; malt sugar group-beta-cyclodextrin; malt-base-gamma-cyclodextrin; G 3-; maltotriose glycosyl-gamma-cyclodextrin; two malt sugar group-beta-cyclodextrins; DE-; glucosyl group-alpha-cyclodextrin; the glucose group-beta-cyclodextrin; the glucosulfone group-beta-cyclodextrin; three-O-methyl-beta-schardinger dextrin-; three-O-ethyl-beta-schardinger dextrin-; three-O-butyryl group-beta-cyclodextrin; three-O-valeryl group-beta-cyclodextrin and two-O-hexanoyl group-beta-cyclodextrin; and methyl-beta-schardinger dextrin-; with their mixture, as malt sugar group-beta-cyclodextrin/two malt sugar group-beta-cyclodextrins.The method for preparing this cyclodextrin derivative is known, for example can be from United States Patent (USP) 5,024, and 998 and introduce in the present invention's list of references as a reference and know.Other is suitable for cyclodextrin of the present invention and comprises the carboxyalkyl sulfide derivative, as ORG 26054 and the ORG 25969 that provides by ORGANON (AKZO-NOBEL), the hydroxy butenyl ether derivant that provides by EASTMAN, sulfoalkyl-hydroxyalkyl ether derivant, sulfoalkyl-alkyl ether derivative and other derivant, for example U.S. Patent application 2002/0128468,2004/0106575,2004/0109888 and 2004/0063663, or United States Patent (USP) 6,610,671,6,479,467,6,660,804 or 6,509,323 described those, they all specifically introduce the present invention as a reference.

HP-can (Flanders NJ) obtains from Research Diagnostics Inc..Exemplary HP-product comprises (substitution value is about 4) and

The dimethyl cyclodextrin can from FLUKA Chemie (Buchs, CH) or Wacker (Iowa) obtain.Other cyclodextrin that is suitable for derivatization of the present invention comprises the cyclodextrin of water miscible derivatization.The cyclodextrin of exemplary water-soluble derivatized comprises carboxylated derivant, sulfated derivative, alkyl derivative, hydroxy alkylated derivant, the derivant that methylates and carboxyl-beta-schardinger dextrin-, for example, and succinyl group-beta-cyclodextrin (SCD).All these raw materials can be according to methods known in the art preparation and/or can be commercially available.The cyclodextrin of the derivatization that is fit to is disclosed in ModifiedCyclodextrins:Scaffolds and Templates for Supramolecular Chemistry (Eds.Christopher J.Easton, Stephen F.Lincoln, Imperial CollegePress, London, UK, 1999) and New Trends in Cyclodextrins andDerivatives (Ed.Dominique Duchene, Editions de Sant é, Paris, France, 1991) in.

As if be used for the example that has the non-ionic surface active agent of good especially physiological compatibility of the present invention is tyloxapol (tyloxapol), polysorbate, polysorbate includes but not limited to polyoxyethylene (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan-monopalmityl ester, polyoxyethylene (20) anhydrosorbitol monostearate (with acquisitions such as commodity Tweens 20-40-60 by name), polysorbate80, PEG400, sodium lauryl sulfate, sorbitan laurate, sorbitan palmitate, sorbitan stearate (with acquisitions such as commodity Span20-40-60 by name), benzalkonium chloride (benzalkonium chloride), PPO-PEO block copolymer (Pluronics), Cremophor-EL, vitamin E-TPGS (as, d-α-fertility base (tocopheryl)-Polyethylene Glycol-1000-succinate), Solutol-HS-15, oleic acid PEO ester, stearic acid PEO ester, Triton-X100, Nonidet P-40 and Polyethylene Glycol (macrogol) hydroxy stearic acid ester such as Polyethylene Glycol-15 hydroxy stearic acid ester.

In some embodiments, being suitable for non-ionic surface active agent of the present invention prepares to form Liposomal formulation, micelle or mixed micelle with corticosteroid.The method of preparation and characterization of liposomes and Liposomal formulation is well known in the art.Usually, when amphipathic lipid can spontaneous formation multilamellar bubble during by hydration, and the formation of little monolayer bubble need relate to the process of a large amount of energy input usually, for example, and ultrasonication or high pressure homogenize.The method of other preparation and characterization of liposomes is described (Preparation and characterization of liposomes astherapeutic delivery systems:a review.Pharm Acta HeIv.1995 by people such as for example S.Vemuri, 70 (2): 95-111) and be described in United States Patent (USP) 5,019,394,5,192,228,5,882,679,6, in 656,497, they all specifically introduce the present invention as a reference.

In some cases.For example, micelle or mixed micelle can be formed by surfactant, and the relatively poor active agent of dissolubility can be dissolved in wherein.Usually, micelle is understood that the spontaneous and dynamic spheric substantially structure of associating and forming by amphiphile, amphiphilic molecule such as surfactant.Mixed micelle is the micelle that is made of dissimilar amphiphile, amphiphilic molecules.Micelle and mixed micelle neither are interpreted as solid particle, because their structure, character and behavior and solid differ greatly.Form the temporary transient usually association of micellar amphiphile, amphiphilic molecule.In micellar solution, form micellar amphiphile and also exist in solution there to be the exchange of dynamic molecule between the dispersive amphiphile of unimolecule form.The structure and the employed surfactant of these molecules depended in the position that is dissolved in the drug molecule in this micelle or the mixed micelle.For example, suppose that nonpolar molecule particularly mainly is positioned at the inside of colloform texture, and polar substances more may be positioned at the surface.In an embodiment of micelle or mixed micelle solution, micellar mean size can be less than about 200nm (detecting with photon correlation spectroscopy (photon correlationspectroscopy)), for example about 10-100nm.Special preferred average diameter is the micelle of about 10-50nm.The method for preparing micelle and mixed micelle is known in the art, and for example is described in the United States Patent (USP) 5,747,066 and 6,906,042, and they all specifically introduce the present invention as a reference.

Other useful cationic stabilized agent includes but not limited to cation lipid, sulfonium, Phosphonium and quaternary ammonium compound, as stearyl trimethyl ammonium chloride, benzyl-two (2-chloro ethyl) ethyl ammonium bromide, the chlorination of cocos nucifera oil trimethyl or ammonium bromide, the dihydroxy ethyl chlorination of cocos nucifera oil methyl or ammonium bromide, decyl triethyl ammonium chloride, the ethoxy chlorination of decyl dimethyl or ammonium bromide, C _12-15Chlorination of dimethyl ethoxy or ammonium bromide, the chlorination of coco dimethyl ethoxy or ammonium bromide, myristyl trimethyl methylsulfuric acid ammonium, the chlorination of lauryl dimethyl benzyl or ammonium bromide, lauryl dimethyl (ethyleneoxy) 4 chlorinations or ammonium bromide, N-alkyl (C _12-18) dimethyl benzyl ammonium chloride, N-alkyl (C _14-18) dimethyl benzyl ammonium chloride, N-myristyl dimethyl benzyl (tetradecylidmethylbenzyl) ammonium chloride monohydrate, dimethyl dodecyl chlorination ammonium (dimethyl didecyl ammonium chloride), N-alkyl and (C _12-14) dimethyl 1-naphthyl methyl ammonium chloride, trimethyl-ammonium halide, alkyl-leptodactyline and dialkyl group-dimethyl ammonium, lauryl trimethyl ammonium chloride, alkylamide (alkyamido) the alkyl dialkyl ammonium salt of ethoxylation and/or trialkyl ammonium salts, dialkyl benzene dialkylammonium chloride, N-dodecyl (N-didecyl) alkyl dimethyl ammonium chloride, N-myristyl dimethyl benzyl ammonium chloride monohydrate, the N-alkyl (C of ethoxylation _12-14) dimethyl 1-naphthyl methyl ammonium chloride and dodecyl dimethyl benzyl ammonium chloride, dialkyl benzene alkyl ammomium chloride, lauryl trimethyl ammonium chloride, alkyl benzyl ammonio methacrylate, alkyl benzyl dimethyl ammonium bromide, C ₁₂, C ₁₅, C ₁₇Trimethylammonium bromide, dodecylbenzyl triethyl ammonium chloride, diallyl dimethyl ammoniumchloride (DADMAC), alkyl dimethyl ammonium chloride, alkyl dimethyl ammonium halide, three cetyl ammonio methacrylates, decyl trimethylammonium bromide, dodecyl triethyl group ammonium bromide, Tetradecyl Trimethyl Ammonium Bromide, (AL1QUAT 336 for methyl trioctylphosphine ammonium chloride ^TM), POLYQUAT 10 ^TM, Tetrabutylammonium bromide, benzyltrimethylammonium bromide, cholinester (as the cholinester of fatty acid), benzalkonium chloride, chlorination stearalkonium chemical compound (for example stearyl trimethyl ammonium chloride (stearyltrimonium chloride) and VARISOFT TA100 (Di-stearyldimonium chloride)), chlorination or cetylpyridinium bromide, quaternised polyoxy ethyl alkylamine halide salts, Mirapol ^TMAnd ALKAQUAT ^TM(AlkarilChemical Company), Fixanol; Amine, for example alkylamine, dialkylamine, alkanolamine, polyethylenepolyamine, acrylic acid N, N-dialkyl aminoalkyl ester and vinyl pyrimidine; Amine salt, as acetic acid lauryl amine, acetic acid stearylamine, Fixanol and alkyl imidazole salt, with amine oxide, acid imide azolinium salt, protonated season acrylamide, the season polymer that methylates, as poly-[diallyldimethylammonium chloride] and poly--[N-methyl ethylene pyridinium chloride] and cationic guar gum.

But except the moisture suction mixture or composition for inhalation that comprise corticosteroid and solubility enhancing agent, the present invention expects that also moisture suction mixture or the compositions prepared by the method that enhanced dissolubility is provided are equally applicable to invention disclosed herein.Therefore, in the context of the invention, " solubility enhancing agent " is included in the moisture suction mixture that is with or without as the method preparation by enhanced dissolubility is provided under the situation of the chemical agent of solubility enhancing agent.This method comprises for example preparation of supercritical fluid.According to this method, corticosteroid composition such as budesonide manufactured have narrow particle size distribution (wide less than 200 nanometers usually), granule mean hydrodynamic radius are the granule of 50 nanometers-700 nanometer.The corticosteroid granule of nano-scale is to use the manufacturing of supercritical fluid (SCF) method as the budesonide granule, described supercritical fluid (SCF) method comprises the rapid expanding (RESS) of supercritical solution, or the solution of supercritical fluid strengthens dispersion (SEDS) and any other relates to the technology of supercritical fluid.Use the SCF method to form particulate summary and see Palakodaty, S. etc., Pharmaceutical Research 16:976-985 (1999), and be described in Bandi etc., Eur.J.Pharm.Sci.23:159-168 (2004), United States Patent (USP) 6,576,264 and U.S. Patent application 2003/0091513 in, they all specifically introduce the present invention as a reference.These methods allow to have the micron of different shape and the granule of submicron-scale according to method selected and parameter formation.In addition, these nano-particle can be made by any other conventional method that spray drying, lyophilization, volume-exclusion and granule reduce.

And the described method for preparing nano-sized particles comprises SCF, can allow by suitably regulate the form that granuloplastic condition selects to expect (for example unformed, crystalline or split racemic) in precipitation or condensation course.Owing to select the particle form of expectation, can realize that the prolongation of the medicine selected discharges.These method for making granules are used to obtain to have high-purity, hang down surperficial imperfection, hang down the nano-particle of surface charge and low deposition rate.This particle characteristic suppresses particle bond, agglomeration, also prevents sedimentation in liquid dispersion.In addition, because method such as SCF can separate the isomer of some drugs, so this separation can help the enhanced activity of medicine, effectiveness and dosage extremely to reduce.In some cases, isomer separation also helps the side effect that reduces.According to the inventive method and system; moisture suction mixture can be to comprise that by any method SCF, spray drying, precipitation and volume-exclusion manufacture the compositions of powder type; directly make trapping medium, wherein granulating compound thereby form dispersive preparation automatically.In some embodiments, said preparation can be final preparation.

SBE-γ-CD, dimethyl beta-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.In some specific embodiments, described solubility enhancing agent is SBE7-β-CD

Any known suction nebulizer all is applicable to invention described herein.This nebulizer comprises the nebulizer and the involving vibrations generator of for example blast atomizer, ultrasound atomizer, pulsation film nebulizer, the vibration net that has a plurality of holes or plate and contains the nebulizer of hydroecium (Pari for example

Aeroneb

(Aerogen, San Francisco, CA), Pari LC

Pari

N and Pari

(PARI Respiratory Equipment, Inc., Monterey, CA),

(Omron Healthcare, Inc, Vemon Hills, Illinois), (Profile Therapeutics Inc, Boston, MA), (Boehringer Ingelheim Ingelheim, Germany),

(Aerogen, Inc, Mountain View, CA), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Omron

(Omron Healthcare, Inc, Vemon Hills, Illinois), Mabismist

(Mabis Healthcare, Inc, LakeForest, Illinois),

6610 (The Lumiscope Company, Inc, EastBrunswick, New Jersey), Airsep

(AirSep Corporation, Buffalo, NY) Acorn-1 and Acorn-II (Vital Signs, Inc, Totowa, NewJersey),

(Medical Industries America, Adel, Iowa),

(Hudson Respiratory Care Incorporated, Temecula, California),

(Intersurgical Incorporated, Liverpool, NewYork),

(Professional Medical Products, Greenwood, SouthCarolina),

Pulmo Aide (DeVilbiss Corp.Somerset, Pennsylvania),

(Marquest, Englewood, Colorado),

(Marquest, Englewood, Colorado), MB-5 (Mefar, Bovezzo, Italy), Misty (Baxter, Valencia, California), Salter 8900 (Salter Labs, Arvin, California),

(Medic-Aid, Sussex, UK),

(Hudson Respiratory Care; Temecula, California), Whisper

(Marquest Medical Products, Englewood, Colorado),

(AiolosMedicnnsk Teknik, Karlstad, Sweden),

(Intertech Resources, Inc., Bannockbum, Illinois),

(Unomedical Inc., McAllen, Texas),

(Respiratory Care Center, Hameenlinna, Finland), AERx (Aradigm Corporation, Hayward, California),

LDI Nebulizer (Evit Labs, Sacramento, California) and Swirler WRadioaerosol System (AMICI, Inc., Spring City, PA).

Any of these and other known nebulizer all can be used for the moisture suction mixture of carrying the present invention to describe.In some embodiments, described nebulizer can obtain from for example PariGmbH (Starnberg, Germany), DeVilbiss Healthcare (Heston, Middlesex, UK), Healthdyne, Vital Signs, Baxter, Allied Health Care, Invacare, Hudson, Omron, Bremed, AirSep, Luminscope, Medisana, Siemens, Aerogen, MountainMedical, Aerosol Medical Ltd. (Colchester, Essex, UK), AFP Medical (Rugby, Warwickshire, UK), Bard Ltd. (Sunderland, UK), Carri-Med Ltd. (Dorking, UK), Plaem Nuiva (Brescia, Italy), Henleys Medical Supplies (London, UK), Intersurgical (Berkshire, UK), Lifecare HospitalSupplies (Leies, UK), Medic-Aid Ltd. (West Sussex, UK), Medix Ltd. (Essex, UK), Sinclair Medical Ltd. (Surrey, UK) and many other companies.

Other nebulizer that is applicable to the method and system that the present invention describes includes but not limited to blast atomizer (randomly selling with compressor), ultrasound atomizer and other nebulizer.Be used for exemplary blast atomizer of the present invention and comprise Pari LC plus/ProNeb, Pari LC plus/ProNebTurbo, Pari LCPlus/Dura Neb 1000 ﹠amp; 2000 Pari LC plus/Walkhaler, PariLC plus/Pari Master, Pari LC Star, the portable atomiser system of Omron CompAir XL (NE-C18 and injection disposable nebulizer (JetAir Disposable nebulizer)), Omron Compare Elite compressor atomiser system (but NE-C21 and Elite Air reuse nebulizer, the Pari LC Plus or the Pari LC Star nebulizer that have Proneb Ultra compressor, Pulomo-aide, Pulmo-aide LT, Pulmo-aide Traveler, Invacare Passport, Inspiration Healthdyne 626, Pulmo-Neb Traveler, DeVilbiss 646, Whisper Jet, AcornII, Misty-Neb, Allied aerosol, Schuco Home Care, Lexan Plasic Pocet Neb, SideStream Hand Held Neb, Mobil Mist, Up-Draft, Up-DraftII, T Up-Draft, ISO-NEB, Ava-Neb, Micro Mist and PulmoMate.

Be used for exemplary ultrasound atomizer of the present invention and comprise MicroAir, UltraAir, SiemensUltra Nebulizer 145, CompAir, Pulmosonic, Scout, 5003 Ultrasonic Neb, 5110 Ultrasonic Neb, 5004 Desk Ultrasonic Nebulizer, MystiqueUltrasonic, Lumiscope ' s Ultrasonic Nebulizer, Medisana UltrasonicNebulizer, Microstat Ultrasonic Nebulizer and Mabismist Hand HeldUltrasonic Nebulizer.Be applicable to that other nebulizer of the present invention comprises 5000Electromagnetic Neb, 5001 Electromagnetic Neb, 5002 Rotary PistonNeb, Lumineb I Piston Nebulizer 5500, Aeroneb Portable NebulizerSystem, Aerodose Inhaler and AeroEclipse Breath Actuated Nebulizer.Comprise that the vibration net with a plurality of holes or the exemplary nebulizer of plate are described in NewNebuliser Technology-Aerosol Generation by Using a Vibrating Meshor Plate with Multiple Apertures, Long-Term Healthcare Strategies2003 by R.Dhand, (in July, 2003), 1-4 page or leaf and Respiratory Care, 47:1406-1416 (2002), its full content is all introduced the present invention as a reference.

Other nebulizer that is applicable to invention described herein comprises the nebulizer that comprises vibration machine and contain hydroecium.This nebulizer is commercial with for example Pari

Sell, and be described in United States Patent (USP) 6,962, in 151,5,518,179,5,261,601 and 5,152,456, they all specifically introduce the present invention as a reference.

In some preferred some embodiment, the nebulizer that method and system as herein described comprises is selected from the nebulizer and the involving vibrations generator of blast atomizer, ultrasound atomizer, pulsation film nebulizer, the vibration net that has a plurality of holes or plate and contains the nebulizer of hydroecium.In some embodiments of the present invention, described nebulizer is selected from Pari LC Jet Plus, Intertech, Baxter Misty-Neb, Hudson T-Updraft II, Hudson Ava-Neb, Aiolos, Pari LC Jet, DeVilbissPulmo-Neb, Hudson Iso-Neb (B), Hudson T-Updraft Neb-U-Mist, Pari-Jet1460 and has the AeroTech of T-pipe.In some other embodiment, described nebulizer is the ParieFlow nebulizer.

In others of the present invention, the method and system that the present invention describes can will contain corticosteroid such as budesonide, and the moisture mixture that sucks is delivered to the experimenter with the treatment effective dose and suffers from treatment or expect the experimenter who suffers from bronchus constriction obstacle, and described bronchus constriction obstacle is selected from the combination in any of asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema or above-mentioned disease.

In the others that the present invention also has, the method and system that the present invention describes comprises that the moisture suction mixture that will contain corticosteroid was no more than (b.i.d) in one day twice according to method and system administration as herein described.Also having on the other hand, described moisture suction mixture contains corticosteroid such as budesonide, and wherein, described moisture suction mixture is according to method and system administration as herein described, one day twice.Having again on the other hand, described moisture suction mixture contains corticosteroid such as budesonide, and wherein, described moisture suction mixture is according to method and system administration as herein described, and one day is no more than once.Still also having on the other hand, described moisture suction mixture contains corticosteroid such as budesonide, and wherein, described moisture suction mixture is according to method and system administration as herein described, once a day.Also having on the other hand, described moisture suction mixture contains corticosteroid such as budesonide, and wherein, described moisture suction mixture is according to method and system as herein described administration at night, and one day is no more than once.

In other embodiments, method and system of the present invention also comprises moisture suction mixture and one or more activating agents combination administration that will contain corticosteroid.In some embodiments, corticosteroid such as budesonide can with one or more other medicine, one or more activating agents combination administrations, described activating agent is selected from: (a) beta 2-adrenergic receptor agonist; (b) dopamine (D2) receptor stimulating agent; (c) prophylactic treatment agent is as steroid; (d) local anesthetic; Or (e) anticholinergic; But with composition for inhalation provided herein simultaneously or before or after give.

In another aspect of this invention, method and system of the present invention can provide by weight the more corticosteroid of effective dose.In some embodiments, can suck corticosteroid treatment with routine and compare, the remarkable by weight more heavy dose of corticosteroid that provides in the moisture suction mixture of system and method as herein described can be absorbed and enter in patient's blood flow.In certain embodiments, system and method as herein described can be carried the suction mixture that contains budesonide and solubility enhancing agent, wherein, described greater than about 55 weight %, perhaps greater than about 50 weight %, or greater than about 45 weight %, or greater than about 40 weight %, or greater than about 35 weight %, or greater than about 30 weight %, or greater than about 25 weight %, or be absorbed greater than the budesonide of the dosage of about 20 weight % and enter blood flow.

In other embodiment that also has, method and system of the present invention can be at the corticosteroid that can suck corticosteroid treatment delivering therapeutic effective dose in the significantly shorter time than routine.For example, give by Pari LC Plus blast atomizer

The nebulisation time of Respules needs 5-8 minute at least usually, in some cases above 10 minutes.By contrast, method and system of the present invention can be less than about 5 minutes to corticosteroid that is less than delivering therapeutic effective dose in about 1.5 minutes time of delivery such as budesonide.In some embodiments, time of delivery can be about 5 minutes.In other embodiments, time of delivery can be less than about 5 minutes.In certain embodiments, time of delivery can be about 4.5 minutes.In some other embodiment, time of delivery can be less than about 4.5 minutes.In other embodiment that also has, time of delivery can be about 4 minutes.In other embodiment that has again, time of delivery can be less than about 4 minutes.In other embodiment that still also has, time of delivery can be about 3.5 minutes.In other embodiments, time of delivery can be less than about 3.5 minutes.In other embodiment that still also has, time of delivery can be about 3 minutes.In other embodiments, time of delivery can be less than about 3 minutes.In certain embodiments, time of delivery can be about 2.5 minutes.In some other embodiment, time of delivery can be less than about 2.5 minutes.In other embodiment that also has, time of delivery can be about 2 minutes.In other embodiment that has again, time of delivery can be less than about 2 minutes.In preferred embodiments, time of delivery can be about 1.5 minutes.In a more preferred embodiment, time of delivery can be less than about 1.5 minutes.

In other embodiments, method and system of the present invention can be carried the corticosteroid of all basically nominal dosage can sucking corticosteroid treatment than routine in the significantly shorter time.For example, give by Pari LC Plus blast atomizer

The nebulisation time of Respules needs 5-8 minute at least usually, in some cases above 10 minutes.By contrast, method and system of the present invention can be less than about 5 minutes to being less than corticosteroid such as the budesonide of carrying nominal dosage in about 1.5 minutes time of delivery.In some embodiments, all basically nominal dosage can be transferred in about 5 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 5 minutes.In certain embodiments, all basically nominal dosage can be transferred in about 4.5 minutes.In some other embodiment, all basically nominal dosage can be transferred being less than in about 4.5 minutes.In other embodiment that also has, all basically nominal dosage can be transferred in about 4 minutes.In other embodiment that has again, all basically nominal dosage can be transferred being less than in about 4 minutes.In other embodiment that still also has, all basically nominal dosage can be transferred in about 3.5 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 3.5 minutes.In other embodiment that still also has, all basically nominal dosage can be transferred in about 3 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 3 minutes.In certain embodiments, all basically nominal dosage can be transferred in about 2.5 minutes.In some other embodiment, all basically nominal dosage can be transferred being less than in about 2.5 minutes.In other embodiment that also has, all basically nominal dosage can be transferred in about 2 minutes.In other embodiment that has again, all basically nominal dosage can be transferred being less than in about 2 minutes.In preferred embodiments, all basically nominal dosage can be transferred in about 1.5 minutes.In a more preferred embodiment, all basically nominal dosage can be transferred being less than in about 1.5 minutes.

In some other embodiment, method and system of the present invention can be can suck the still less corticosteroid of the unit dose delivering therapeutic effective dose of volume of corticosteroid treatment than routine.For example, corticosteroid such as budesonide that method and system of the present invention can the delivering therapeutic effective dose, wherein, the volume of described moisture suction mixture arrives less than 5ml for about 0.5ml.In some embodiments, the volume of described moisture suction mixture can be about 3.5ml.In other embodiments, the volume of described moisture suction mixture can be about 3.0ml.In other embodiment that also has, the volume of described moisture suction mixture can be about 2.5ml.In other embodiment that has again, the volume of described moisture suction mixture can be about 2.0ml.In certain embodiments, the volume of described moisture suction mixture can be about 1.5ml.In some other embodiment, the volume of described moisture suction mixture can be about 1.0ml.In preferred embodiments, the volume of described moisture suction mixture can be about 0.5ml.

Should be understood that the various aspects of method and system described herein can comprise one or more any or all advantages provided by the invention, additional embodiment within the scope of the invention.For example, method and system described herein can provide a kind of aqueous mixture, this mixture comprises the corticosteroid and the solubility enhancing agent of the nominal dosage of about 60 μ g/ dosage, the volume of described suction mixture is about 0.5ml, with the suction nebulizer, wherein, the aqueous mixture that contains corticosteroid is less than about 2 minutes by the conveying of nebulizer, wherein, carry the moisture suction mixture that contains corticosteroid to cause the enhanced PK (pharmacokinetic) profile of corticosteroid by described nebulizer, make when nominal dosage to be nominal dosage about 60% time of described the sucked suspension that contains corticosteroid less than the described moisture suction mixture that contains corticosteroid of about 100 μ g/ dosage, described C _MaximumEqual to contain the C of the sucked suspension of corticosteroid _MaximumAbove-mentioned embodiment only is to embody the example of one embodiment of this invention of multiple aspect of the present invention or variation, never is intended to limit the scope of the invention.

A. the conveying of corticosteroid shows enhanced PK (pharmacokinetic) profile

The present invention can also provide a kind of method or system that is used at patient's treatment or prevention bronchus constriction obstacle, this method or system comprise provides the corticosteroid that contains nominal dosage and the moisture suction mixture of solubility enhancing agent, and carries described moisture suction mixture by sucking nebulizer.In these embodiments, the conveying of the described method corticosteroid that can provide shows the enhanced PK (pharmacokinetic) profile of the corticosteroid formulations based on suspension than administration under the same conditions.

In certain embodiments, method and system of the present invention can be treated in the patient who needs is arranged or prevention bronchus constriction obstacle, comprise: a kind of corticosteroid of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising (a) is provided, (b) carry the described moisture suction mixture that comprises corticosteroid with nebulizer, thus, with comprising of administration under the same conditions nominal dosage corticosteroid sucked suspension as Pulmicort

PK (pharmacokinetic) profile compare, described method and system provides at least 2 times of enhanced PK (pharmacokinetic) profile that comprise the moisture suction mixture of nominal dosage corticosteroid.In some embodiments, the described aqueous mixture that sucks can show with the routine that contains corticosteroid and can suck the suitable basically corticosteroid bioavailability of suspension when using obviously lower nominal dosage.In other embodiments, the described aqueous mixture that sucks can show than the routine that contains corticosteroid and can suck the corticosteroid bioavailability that suspension increases when carrying with identical nominal dosage.In certain embodiments, the nominal dosage of corticosteroid arrives about 1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension for about 0.01:1 in the described moisture suction mixture.

In other embodiments, method and system of the present invention can be treated in the patient who needs is arranged or prevention bronchus constriction obstacle, comprise: a kind of single corticosteroid of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising (a) is provided, (b) carry the described moisture suction mixture that comprises corticosteroid with nebulizer, thus, with comprising of administration under the same conditions nominal dosage corticosteroid sucked suspension as Pulmicort

PK (pharmacokinetic) profile compare, described method and system provides at least 2 times of enhanced PK (pharmacokinetic) profile that comprise the moisture suction mixture of nominal dosage corticosteroid, wherein, described suction mixture is gone up the pharmaceutically active agents that does not contain except that the cortex steroid substantially.In some embodiments, the described aqueous mixture that sucks can show with the routine that contains corticosteroid and can suck the suitable basically corticosteroid bioavailability of suspension when using obviously lower nominal dosage.In other embodiments, the described aqueous mixture that sucks can show than the routine that contains corticosteroid and can suck the corticosteroid bioavailability that suspension increases when carrying with identical nominal dosage.In certain embodiments, the nominal dosage of corticosteroid arrives about 1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension for about 0.01:1 in the described moisture suction mixture.

In certain embodiments, the moisture suction mixture that contains corticosteroid that adopts method described herein the to carry C that can obtain _MaximumGreater than under the same conditions with the C based on the corticosteroid formulations of suspension of identical nominal dosed administration _MaximumIn other embodiments, the moisture suction mixture that contains corticosteroid that adopts method described herein the to carry AUC that can obtain _{(at last)}Greater than under the same conditions with the AUC based on the corticosteroid formulations of suspension of identical nominal dosed administration ₍ _{The back)}In other embodiment that still has, the AUC that the moisture suction mixture that contains corticosteroid that adopts method described herein to carry can obtain _(0-∞)Greater than under the same conditions with the AUC based on the corticosteroid formulations of suspension of identical nominal dosed administration _(0-∞)In other embodiment that also has, the T that the moisture suction mixture that contains corticosteroid that adopts method described herein to carry can obtain _MaximumT less than administration under the same conditions based on the corticosteroid formulations of suspension _Maximum

In some other embodiment, the C that the moisture suction mixture that contains corticosteroid that adopts method described herein to carry can obtain _MaximumBe equivalent to C based on the corticosteroid formulations of suspension _Maximum, wherein, the nominal dosage of described moisture suction mixture is lower than the nominal dosage based on the corticosteroid formulations of suspension of administration under the same conditions.In other embodiments, the moisture suction mixture that contains corticosteroid that adopts method described herein the to carry AUC that can obtain _{(at last)}Be equivalent to AUC based on the corticosteroid formulations of suspension _{(at last)}, wherein, the nominal dosage of described moisture suction mixture is lower than the nominal dosage based on the corticosteroid formulations of suspension of administration under the same conditions.In other embodiment that still has, the AUC that the moisture suction mixture that contains corticosteroid that adopts method described herein to carry can obtain _(0-∞)Be equivalent to AUC based on the corticosteroid formulations of suspension _(0-∞), wherein, the nominal dosage of described moisture suction mixture is lower than the nominal dosage based on the corticosteroid formulations of suspension of administration under the same conditions.In other embodiment that also has, the T that the moisture suction mixture that contains corticosteroid that adopts method described herein to carry can obtain _MaximumLess than T based on the corticosteroid formulations of suspension _Maximum, wherein, the nominal dosage of described moisture suction mixture is lower than the nominal dosage based on the corticosteroid formulations of suspension of administration under the same conditions.

As previously mentioned, the corticosteroid that is exposed to high blood plasma level of increase may cause the side effect do not expected.Therefore, expectation can obtain can suck with the routine than heavy dose the corticosteroid than low dosage of the identical or better healing effect of corticosteroid treatment.Thisly can realize that than low dosage this is owing to can suck the result of the bigger corticosteroid bioavailability of suspension than the routine that contains corticosteroid with method and system described herein.With containing of administration under the same conditions nominal dosage corticosteroid sucked suspension as Pulmicort

PK (pharmacokinetic) profile compare, method and system described herein can be with particular treatment parameter (for example, the AUC at least about 1.5 times (150%)-Yue 10 times (1000%) _(0-∞)), carry corticosteroid with the enhanced PK (pharmacokinetic) profile of the moisture suction mixture that contains nominal dosage corticosteroid, thereby enhanced PK (pharmacokinetic) profile is provided.In certain embodiments, the nominal dosage of corticosteroid is the about 1:100 of about 0.01:1-with the described ratio that sucks the nominal dosage of corticosteroid in the suspension in the described moisture suction mixture.

In other embodiments, method and system described herein can be carried the moisture suction mixture of the corticosteroid that contains nominal dosage, it has than the enhanced PK (pharmacokinetic) profile of the sucked suspension that contains nominal dosage corticosteroid, comprise suitable bioavailability (for example, suitable AUC _(0-∞)), wherein, the nominal dosage of corticosteroid is at least about 1:1.5-1:10 with the ratio that routine can suck the nominal dosage of corticosteroid in the suspension in the described moisture suction mixture, so that enhanced PK (pharmacokinetic) profile (PK (pharmacokinetic) profile strengthens 1.5 times to about 10 times) to be provided.

In certain embodiments, method and system of the present invention can be treated in the patient who needs is arranged or prevention bronchus constriction obstacle, comprise: a kind of corticosteroid of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising (a) is provided, (b) carry the described moisture suction mixture that comprises corticosteroid with sucking nebulizer, the PK (pharmacokinetic) profile of the moisture suction mixture that contains nominal dosage corticosteroid that thus, described method and system provides strengthens about 1.5 times (150%)-Yue 10 times (1000%) than the PK (pharmacokinetic) profile of the sucked suspension that contains nominal dosage corticosteroid of administration under the same conditions.In other embodiments, described suction mixture comprises single corticosteroid and is substantially devoid of other medicines active agent except that described corticosteroid.In one embodiment, adopt the described moisture suction mixture that contains nominal dosage corticosteroid of system and method administration described herein can provide than containing of administration under the same conditions nominal dosage corticosteroid routine can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times (150%)-Yue 9 times (900%).In another embodiment, adopt the described moisture suction mixture that contains nominal dosage corticosteroid of system and method administration described herein can provide than containing of administration under the same conditions nominal dosage corticosteroid routine can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-8 times (800%).In also having another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-7 times (700%).In the another embodiment that still has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-6 times (600%).In one embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-5 times (500%).In the another embodiment that also has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-4 times (400%).In the another embodiment that still has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-3 times (300%).In also having another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 1.5 times of (150%)-2 times (200%).In one embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 2 times (200%).In another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 3 times (300%).In also having another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 4 times (400%).In the another embodiment that still has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 5 times (500%).In the another embodiment that still also has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage corticosteroid and can have than the routine that contains nominal dosage corticosteroid and can suck the PK (pharmacokinetic) profile that suspension strengthens about 6 times (600%).

At some in other the embodiment, a kind of moisture suction mixture that contains nominal dosage budesonide and solubility enhancing agent adopts system and method described herein to carry, and have than containing of administration under the same conditions nominal dosage budesonide routine can suck suspension and strengthen PK (pharmacokinetic) profile at least about 2 times of (200%)-6 times (600%).In one embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage budesonide and can have than the routine that contains nominal dosage budesonide and can suck the PK (pharmacokinetic) profile that suspension strengthens about 2 times (200%).In another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage budesonide and can have than the routine that contains nominal dosage budesonide and can suck the PK (pharmacokinetic) profile that suspension strengthens about 3 times (300%).In also having another embodiment, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage budesonide and can have than the routine that contains nominal dosage budesonide and can suck the PK (pharmacokinetic) profile that suspension strengthens about 4 times (400%).In the another embodiment that still has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage budesonide and can have than the routine that contains nominal dosage budesonide and can suck the PK (pharmacokinetic) profile that suspension strengthens about 5 times (500%).In the another embodiment that still also has, during administration under the same conditions, adopt system and method described herein to give the described moisture suction mixture that contains nominal dosage budesonide and can have than the routine that contains nominal dosage budesonide and can suck the PK (pharmacokinetic) profile that suspension strengthens about 6 times (600%).

Owing to the enhanced PK (pharmacokinetic) profile that provides by method and system as herein described, be used for to carry the moisture mixture that sucks that contains corticosteroid with bioavailability suitable with the sucked suspension that contains corticosteroid in this method and the system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, the described moisture nominal dosage that sucks mixture that contains corticosteroid is about 1:1.5-1:10 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In one embodiment, method and system of the present invention can be provided in treatment or prevention bronchus constriction obstacle among the patient who needs, described method and system comprises: (1) provides a kind of moisture suction mixture and (2) that comprise corticosteroid and solubility enhancing agent to carry described moisture suction mixture with the suction nebulizer, wherein, carry the described aqueous mixture that contains corticosteroid can obtain to suck the suitable corticosteroid bioavailability of suspension by described nebulizer with the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:10 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In another embodiment, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:9 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In also having another embodiment, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:8 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In the another embodiment that has again, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:7 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In the another embodiment that also has, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:6 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In one embodiment, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:5 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In the another embodiment that has again, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:4 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In the another embodiment that also has, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:3 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In the another embodiment that still also has, the moisture suction mixture that contains corticosteroid by system and method described herein can obtain can suck the enhanced PK (pharmacokinetic) profile of suspension than the routine that contains corticosteroid, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:1.5-1:2 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.

In other embodiments, a kind of moisture suction mixture that contains corticosteroid and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains corticosteroid and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:2-1:10 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In other embodiment that also has, a kind of moisture suction mixture that contains corticosteroid and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains corticosteroid and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:2-1:5 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In other embodiment that still also has, a kind of moisture suction mixture that contains corticosteroid and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains corticosteroid and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:2-1:4 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.In other embodiment that also has, a kind of moisture suction mixture that contains corticosteroid and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains corticosteroid and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of the described moisture suction mixture that contains corticosteroid is about 1:4 with the ratio of the nominal dosage of the sucked suspension that contains corticosteroid.

At some in other the embodiment, a kind of moisture suction mixture that contains budesonide and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains budesonide and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of described moisture suction mixture is about 1:2-1:10 with the ratio of the nominal dosage of the sucked suspension that contains budesonide.In other embodiment that also has, a kind of moisture suction mixture that contains budesonide and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains budesonide and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of described moisture suction mixture is about 1:2-1:5 with the ratio of the nominal dosage of the sucked suspension that contains budesonide.In other embodiment that still also has, a kind of moisture suction mixture that contains budesonide and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains budesonide and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of described moisture suction mixture is about 1:2-1:4 with the ratio of the nominal dosage of the sucked suspension that contains budesonide.In other embodiment that also has, a kind of moisture suction mixture that contains budesonide and solubility enhancing agent is carried by system and method described herein, and have than the routine that contains budesonide and can suck the enhanced PK (pharmacokinetic) profile of suspension, wherein, the nominal dosage of described moisture suction mixture is about 1:4 with the ratio of the nominal dosage of the sucked suspension that contains budesonide.

In certain embodiments, method and system of the present invention can suck the still less corticosteroid of the unit dose delivering therapeutic effective dose of volume of corticosteroid treatment to comprise than routine.For example, corticosteroid such as budesonide that method and system of the present invention can the delivering therapeutic effective dose, wherein, the volume of described moisture suction mixture arrives less than 5ml for about 0.5ml.In some embodiments, the volume of described moisture suction mixture can be about 3.5ml.In other embodiments, the volume of described moisture suction mixture can be about 3.0ml.In other embodiment that also has, the volume of described moisture suction mixture can be about 2.5ml.In other embodiment that has again, the volume of described moisture suction mixture can be about 2.0ml.In certain embodiments, the volume of described moisture suction mixture can be about 1.5ml.In some other embodiment, the volume of described moisture suction mixture can be about 1.0ml.In preferred embodiments, the volume of described moisture suction mixture can be about 0.5ml.

In other embodiments, method and system of the present invention can be carried the corticosteroid of all nominal dosage basically in the significantly shorter time can sucking corticosteroid treatment than routine.For example, give by Pari LC Plus blast atomizer

The nebulisation time of Respules needs 5-8 minute at least usually, in some cases above 10 minutes.By contrast, method and system of the present invention can be carried the corticosteroid such as the budesonide of all nominal dosage basically to being less than in about 1.5 minutes time of delivery being less than about 5 minutes.In some embodiments, all basically nominal dosage can be transferred in about 5 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 5 minutes.In certain embodiments, all basically nominal dosage can be transferred in about 4.5 minutes.In some other embodiment, all basically nominal dosage can be transferred being less than in about 4.5 minutes.In other embodiment that also has, all basically nominal dosage can be transferred in about 4 minutes.In other embodiment that has again, all basically nominal dosage can be transferred being less than in about 4 minutes.In other embodiment that still also has, all basically nominal dosage can be transferred in about 3.5 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 3.5 minutes.In other embodiment that still also has, all basically nominal dosage can be transferred in about 3 minutes.In other embodiments, all basically nominal dosage can be transferred being less than in about 3 minutes.In certain embodiments, all basically nominal dosage can be transferred in about 2.5 minutes.In some other embodiment, all basically nominal dosage can be transferred being less than in about 2.5 minutes.In other embodiment that also has, all basically nominal dosage can be transferred in for about 2 minutes.In other embodiment that has again, all basically nominal dosage can be transferred being less than in about 2 minutes.In preferred embodiments, all basically nominal dosage can be transferred in for about 1.5 minutes.In a more preferred embodiment, all basically nominal dosage can be transferred being less than in about 1.5 minutes.

B. plasma C _MaximumValue

As herein described being used for can be delivered to the experimenter with the suction mixture that contains corticosteroid in the following manner at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, the routine that the active substance that is transferred has than administration under the same conditions can suck the corticosteroid plasma C that the corticosteroid suspension increases _MaximumValue.In one embodiment, use Pari LC

Blast atomizer is with the volume of 2.0ml, about 5 minutes administration time, and the PK (pharmacokinetic) profile so that the conventional budesonide suspension of single dose administration shows makes that nominal dosage is the plasma C of 500-1000 μ g _MaximumValue is respectively about 556 ± 193 (pg/ml)-1114 ± 593 (pg/ml).Use method and system as herein described, utilize Pari eFlow

With single dose delivered volume in about 1.5 minutes time of deliveries is that the nominal dosage of 0.5ml is budesonide+SBE7-β-CD of 60 μ g, 120 μ g and 240 μ g when sucking solution, plasma C _MaximumValue is respectively about 227 ± 89 (pg/ml), about 578 ± 238 (pg/ml) and 1195 ± 811 (pg/ml).Fig. 4 provides and has produced above-mentioned plasma C _MaximumThe graphic representation of the data that value adopted.

In second example, utilize Pari LC

Blast atomizer gave volume in the administration time at about 4 minutes be that the nominal dosage of 2.0ml is the conventional budesonide suspension (Pulmicort of 250 μ g and 500 μ g

One day twice, continue 7 days, the plasma C of its PK (pharmacokinetic) profile _MaximumMeansigma methods is respectively about 319.6 ± 185pg/ml and about 491.4 ± 207pg/ml.250 identical μ g and 500 μ g Pulmicort

Suck the plasma C of suspension _MaximumGeometrical mean is respectively about 270.5pg/ml and 451.6pg/ml.Use method and system as herein described, utilize Pari eFlow Delivered volume is that the 60 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma C _GreatlyValue is about 186.4pg/ml, maximum plasma C _MaximumValue is about 779.4pg/ml, C _MaximumGeometrical mean is about 362.2pg/ml.Similarly, utilize Pari eFlow Delivered volume is that the 120 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma C _MaximumValue is about 169.8pg/ml, maximum plasma C _MaximumValue is about 1160.4pg/ml, C _MaximumGeometrical mean is about 516.9pg/ml.Fig. 5 provides above-mentioned plasma C _MaximumThe graphic representation of the data of value institute foundation.

Therefore, the described conveying that is used for providing the suction mixture that contains nominal dosage corticosteroid, this suction mixture at the method and system of patient treatment that needs are arranged or prevention bronchus constriction obstacle have than containing of administration under the same conditions nominal dosage corticosteroid routine can suck the enhanced PK (pharmacokinetic) profile of corticosteroid suspension.More specifically, in certain embodiments, system and method as herein described provides the routine than administration under the same conditions can suck the C of corticosteroid treatment increase at least about 1.5-14 plasma corticosterone steroid doubly _MaximumValue (is that benchmark is measured with the individuality), wherein, corticosteroid carries out standardization according to the dosage of the corticosteroid of the every microgram corticosteroid that gives.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 1.5-13 doubly, about 1.5-12 doubly, about 1.5-10 doubly, about 1.5-8 doubly, about 1.5-7.5 doubly, about 1.5-7 doubly, about 1.5-6.5 doubly, about 1.5-6.25 doubly, the C of the plasma corticosterone steroid of about 1.5-6 times, about 1.5-5.75 times, about 1.5-5.5 times, about 1.5-5 times, about 1.5-4.75 times, about 1.5-4.5 times, about 1.5-4 times _MaximumValue (is that benchmark is measured with the individuality), this C _MaximumValue is carried out standardization at the corticosteroid dosage of the corticosteroid that every microgram gives.

In other embodiments, for example determine that described herein being used for treats or prevent the method and system of bronchus constriction obstacle to provide the routine than administration under the same conditions can suck the C of corticosteroid treatment increase at least about 4-7 times plasma corticosterone steroid the patient that needs are arranged as the geometric average of utilizing research patient colony of institute _MaximumValue, this C _MaximumValue is at the patient colony value of being studied, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 4-7 doubly, about 4-6.5 doubly, about 4-6.25 doubly, about 4-6 doubly, about 4-5.75 doubly, the C of the plasma corticosterone steroid of about 4-5.5 times, about 4-5 times, about 5-7 times, about 5.5-7 times, about 6-7 times _MaximumValue, this C _MaximumValue is at the patient colony value of being studied, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.

In some embodiments, C _MaximumCan be higher than the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration significantly _MaximumValue.In certain embodiments, C _MaximumIt can be the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration _MaximumAbout 1.5 times of (150%)-14 times (1400%) of value.In other embodiments, C _MaximumIt can be the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration _MaximumAbout 1.5 times of (150%)-12 times (1200%) of value.In other embodiment that also has, C _MaximumIt can be the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration _MaximumAbout 1.5 times of (150%)-10 times (1000%) of value.In one embodiment, C _MaximumIt can be the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration _MaximumThe value at least about 12 times (1200%).At some in other the embodiment, C _GreatlyIt can be the plasma C that can suck the suspension demonstration under the same conditions with the routine that contains corticosteroid of identical nominal dosed administration _MaximumThe value at least about 1000% (10 times)-1200% (12 times), about 1100% (11 times)-1200% (12 times) or about 1150% (11.5 times)-1200% (12 times).In other embodiments, described enhanced PK (pharmacokinetic) profile comprises the C of described moisture suction mixture _MaximumBe higher than under the same conditions C with the sucked suspension that contains corticosteroid of identical nominal dosed administration _MaximumIn one embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 1000% (10 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 900% (9 times)-1000% (10 times), about 925% (9.25 times)-1000% (10 times) or about 950% (9.5 times)-1000% (10 times).In another embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 900% (9 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 800% (8 times)-900% (9 times), about 825% (8.25 times)-900% (9 times) or about 850% (8.5 times)-900% (9 times).In the another embodiment that also has, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 800% (8 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 700% (7 times)-800% (8 times), about 725% (7.25 times)-800% (8 times) or about 750% (7.5 times)-800% (8 times).In the another embodiment that still also has, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 700% (7 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 600% (6 times)-700% (7 times), about 625% (6.25 times)-700% (7 times) or about 650% (6.5 times)-700% (7 times).In one embodiment, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 600% (6 times).At some in other the embodiment, C _GreatlyCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 500% (5 times)-600% (6 times), about 525% (5.25 times)-600% (6 times) or about 550% (5.5 times)-600% (6 times).In another embodiment, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 500% (5 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 400% (4 times)-500% (5 times), about 425% (4.25 times)-500% (5 times) or about 450% (4.5 times)-500% (5 times).In the another embodiment that also has, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 400% (4 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 300% (3 times)-400% (4 times), about 325% (3.25 times)-400% (4 times) or about 350% (3.5 times)-400% (4 times).In the another embodiment that also has, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 300% (3 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 200% (2 times)-300% (3 times), about 225% (2.25 times)-300% (3 times) or about 250% (2.5 times)-300% (3 times).In the another embodiment that still also has, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 200% (2 times).At some in other the embodiment, C _MaximumCan be to suck the shown plasma C of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _MaximumThe value at least about 150% (1.5 times)-200% (2 times).In another embodiment, C _MaximumBe the C that contains the sucked suspension of corticosteroid _MaximumAt least about 150% (1.5 times).

In other embodiments, C _MaximumThe routine that can be equivalent to contain corticosteroid basically can suck the shown plasma C of suspension _MaximumValue, wherein, the moisture suction mixture that contains corticosteroid is with lower nominal dosage administration under the same conditions.In one embodiment, the ratio that described nominal dosage and the routine that contains corticosteroid can suck the nominal dosage of suspension can be about 1:1.5 (promptly, 1.5 doubly enhanced PK (pharmacokinetic) profile)-1:10 (that is 10 times of enhanced PK (pharmacokinetic) profile).In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that has again, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In certain embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other the embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension at some.In other some embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1: 4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:10 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.

C. plasma A UC _{(at last)}Value

As herein described being used for can be delivered to the experimenter with the suction mixture that contains corticosteroid in the following manner at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, the routine that the active substance that is transferred has than administration under the same conditions can suck the corticosteroid plasma A UC that the corticosteroid suspension increases _{(at last)}Value.For example, utilize Pari LC Blast atomizer is with the volume of 2.0ml, about 5 minutes administration time, and the PK (pharmacokinetic) profile that shows with the conventional budesonide suspension of single dose administration makes that nominal dosage is the plasma A UC of 500-1000 μ g _{(at last)}Value is respectively about 739 ± 220 (pg/h/ml)-1989 ± 379 (pg/h/ml).Use method and system as herein described, utilize Pari eFlow

With single dose delivered volume in about 1.5 minutes time of deliveries is that the nominal dosage of 0.5ml is budesonide+SBE7-β-CD of 60 μ g, 120 μ g and 240 μ g when sucking solution, plasma A UC _{At last}Value is respectively about 179 ± 75 (pg/h/ml), about 569 ± 213 (pg/h/ml) and about 1183 ± 328 (pg/h/ml).Fig. 4 provides and has produced above-mentioned plasma A UC _{(at last)}The graphic representation of the data that value adopted.

In second example, utilize Pari LC

), one day twice, continue 7 days, the plasma A UC of its PK (pharmacokinetic) profile _{(at last)}Meansigma methods is respectively about 361.1 ± 212pg/ml and about 811.1 ± 328pg/ml.250 identical μ g and 500 μ g Pulmicort

Suck the plasma A UC of suspension _{(at last)}Geometrical mean is respectively about 302.6pg/ml and 735.1pg/ml.Use method and system as herein described, utilize Pari eFlow

Delivered volume is that the 60 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma A UC _{(at last)}Value is about 106.4pg/ml, maximum plasma A UC _{(at last)}Value is about 463.1pg/ml, AUC _{(at last)}Geometrical mean is about 293.7pg/ml.Similarly, utilize Pari eFlow

Delivered volume is that the 120 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma A UC _{(at last)}Value is about 168.2pg/ml, maximum plasma A UC _{(at last)}Value is about 1496.7pg/ml, AUC _{(at last)}Geometrical mean is about 621.4pg/ml.Fig. 5 provides above-mentioned plasma A UC _{(at last)}The graphic representation of the data of value institute foundation.

Therefore, the described conveying that is used for providing at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle the suction mixture that contains corticosteroid, the routine that this suction mixture has than administration under the same conditions can suck the enhanced PK (pharmacokinetic) profile of corticosteroid suspension.More specifically, system and method as herein described provides the routine than administration under the same conditions can suck the corticosteroid treatment increase at least about 1.5-10 corticosteroid plasma A UC doubly _{(at last)}Value (is that benchmark is measured with the individuality), this AUC _{(at last)}Value is carried out standardization at the corticosteroid dosage of the corticosteroid that every microgram gives.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 1.5-10 doubly, about 1.5-9.5 doubly, about 1.5-9 doubly, about 1.5-8.5 doubly, about 1.5-8 doubly, about 1.5-7.75 doubly, about 1.5-7.5 doubly, about 1.5-7.25 doubly, about 1.5-7 doubly, the corticosteroid plasma A UC of about 1.5-6.75 times, about 1.5-6.5 times, about 1.5-6 times, about 1.5-5.75 times, about 1.5-5.5 times, about 1.5-5 times, about 1.5-4.75 times, about 1.5-4.5 times, about 1.5-4 times _{(at last)}Value (is that benchmark is measured with the individuality), this AUC _{(at last)}Value is carried out standardization at the corticosteroid dosage of the corticosteroid that every microgram gives.

In other embodiments, for example determine that described herein being used for treats or prevent the method and system of bronchus constriction obstacle to provide routine than administration under the same conditions can suck the corticosteroid treatment increase at least about 4-6 times corticosteroid plasma A UC the patient that needs are arranged as the geometric average of utilizing research patient colony of institute _{(at last)}Value, this AUC _{(at last)}Value is at the patient colony value of being studied, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 4-6 doubly, about 4-5.75 doubly, about 4-5.5 doubly, about 4-5.25 doubly, about 4-5 doubly, the corticosteroid plasma A UC of about 4.5-6 times, about 4.75-6 times, about 5-6 times, about 5.5-6 times _{(at last)}Value, this AUC _{(at last)}Value is at the patient colony value of being studied, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.

In some embodiments, the AUC that provides of the described method and system that is used at patient treatment that needs are arranged or prevention bronchus constriction obstacle _{(at last)}Can be significantly can suck the shown plasma A UC of suspension greater than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions ₍ _{The back)}Value.In certain embodiments, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}About 1.5 times of (150%)-10 times (1000%) of value.In one embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}At least 10 times (1000%) of value.At some in other the embodiment, AUC ₍ _{The back)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}About 900% (9 times)-1000% (10 times), about 925% (9.25 times)-1000% (10 times) or about 950% (9.5 times)-1000% (10 times) of value.In another embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 900% (9 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 800% (8 times)-900% (9 times), about 825% (8.25 times)-900% (9 times) or about 850% (8.5 times)-900% (9 times).In the another embodiment that also has, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 800% (8 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 700% (7 times)-800% (8 times), about 725% (7.25 times)-800% (8 times) or about 750% (7.5 times)-800% (8 times).In the another embodiment that still also has, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 700% (7 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 600% (6 times)-700% (7 times), about 625% (6.25 times)-700% (7 times) or about 650% (6.5 times)-700% (7 times).In one embodiment, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 600% (6 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 500% (5 times)-600% (6 times), about 525% (5.25 times)-600% (6 times) or about 550% (5.5 times)-600% (6 times).In another embodiment, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 500% (5 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 400% (4 times)-500% (5 times), about 425% (4.25 times)-500% (5 times) or about 450% (4.5 times)-500% (5 times).In the another embodiment that also has, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 400% (4 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 300% (3 times)-400% (4 times), about 325% (3.25 times)-400% (4 times) or about 350% (3.5 times)-400% (4 times).In the another embodiment that also has, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 300% (3 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 200% (2 times)-300% (3 times), about 225% (2.25 times)-300% (3 times) or about 250% (2.5 times)-300% (3 times).In the another embodiment that still also has, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 200% (2 times).At some in other the embodiment, AUC _{(at last)}Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _{(at last)}The value at least about 150% (1.5 times)-200% (2 times).In another embodiment, AUC _{(at last)}Be the AUC that contains the sucked suspension of corticosteroid _{(at last)}At least about 150% (1.5 times).

In some embodiments, AUC _{(at last)}The routine that can be equivalent to contain corticosteroid basically can suck the shown plasma A UC of suspension _{(at last)}Value, wherein, described moisture suction mixture is with lower nominal dosage administration under the same conditions.In one embodiment, the ratio that described nominal dosage and the routine that contains corticosteroid can suck the nominal dosage of suspension can be about 1:1.5 (promptly, 1.5 doubly enhanced PK (pharmacokinetic) profile)-1:10 (that is 10 times of enhanced PK (pharmacokinetic) profile).In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that has again, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In certain embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other the embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension at some.In other some embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:10 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.

D. plasma A UC _(0-∞)Value

As herein described being used for can be delivered to the experimenter with corticosteroid in the following manner at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, the routine that the active substance that is transferred has than administration under the same conditions can suck the corticosteroid plasma A UC that the corticosteroid suspension increases _(0-∞)Value.For example, utilize Pari LC

Blast atomizer is with the volume of 2.0ml, about 5 minutes administration time, and the PK (pharmacokinetic) profile that shows with the conventional budesonide suspension of single dose administration makes that nominal dosage is the plasma A UC of 500-1000 μ g _(0-∞)Value is respectively about 867 ± 216 (pg/h/ml)-2083 ± 394 (pg/h/ml).Use method and system as herein described, utilize Pari eFlow

With single dose delivered volume in about 1.5 minutes time of deliveries is that the nominal dosage of 0.5ml is budesonide+SBE7-β-CD of 60 μ g, 120 μ g and 240 μ g when sucking solution, plasma A UC _(0-∞)Value is respectively about 262 ± 125 (pg/h/ml), about 679 ± 201 (pg/ml) and 1365 ± 313 (pg/h/ml).Fig. 4 provides and has produced above-mentioned plasma A UC _(0-∞)The graphic representation of the data that value adopted.

In second example, utilize Pari LC

), one day twice, continue 7 days, the plasma A UC of its PK (pharmacokinetic) profile _(0-∞)Meansigma methods is respectively about 472.3 ± 230pg/ml and about 945.7 ± 363pg/ml.250 identical μ g and 500 μ g Pulmicort

Suck the plasma A UC of suspension _(0-∞)Geometrical mean is respectively about 413.0pg/ml and 874.6pg/ml.Use method and system as herein described, utilize Pari eFlow

Delivered volume is that the 60 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma A UC _(0-∞)Value is about 156.5pg/ml, maximum plasma A UC _(0-∞)Value is about 748.5pg/ml, AUC _(0-∞)Geometrical mean is about 396.1pg/ml.Similarly, utilize Pari eFlow

Delivered volume is that the 120 μ g CBIS of 0.5ml suck solution in about 1.5 minutes time of deliveries, one day twice, continues 7 days, minimum plasma A UC _(0-∞)Value is about 221.4pg/ml, maximum plasma A UC _(0-∞)Value is about 1863.7pg/ml, AUC _(0-∞)Geometrical mean is about 752.2pg/ml.Fig. 5 provides AUC in the above-mentioned blood plasma _(0-∞)The graphic representation of the data of value institute foundation.

Therefore, the conveying that is used for providing at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle corticosteroid as herein described, the routine that this corticosteroid has than administration under the same conditions can suck the enhanced PK (pharmacokinetic) profile of corticosteroid suspension.More specifically, system and method as herein described provides the routine than administration under the same conditions can suck the corticosteroid treatment increase at least about 1.5-10 corticosteroid plasma A UC doubly _(0-∞)Value (is that benchmark is measured with the individuality), this AUC _(0-∞)Value is carried out standardization at the corticosteroid dosage of the corticosteroid that every microgram gives.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 1.5-10 doubly, about 1.5-9.5 doubly, about 1.5-9 doubly, about 1.5-8.5 doubly, about 1.5-8 doubly, about 1.5-7.75 doubly, about 1.5-7.5 doubly, about 1.5-7.25 doubly, about 1.5-7 doubly, the corticosteroid plasma A UC of about 1.5-6.75 times, about 1.5-6.5 times, about 1.5-6 times, about 1.5-5.75 times, about 1.5-5.5 times, about 1.5-5 times, about 1.5-4.75 times, about 1.5-4.5 times, about 1.5-4 times _(0-∞)Value (is that benchmark is measured with the individuality), this AUC _(0-∞)Value is carried out standardization at the corticosteroid dosage of the corticosteroid that every microgram gives.

In other embodiments, for example determine that described herein being used for treats or prevent the method and system of bronchus constriction obstacle to provide routine than administration under the same conditions can suck the corticosteroid treatment increase at least about 4-6 times corticosteroid plasma A UC the patient that needs are arranged as the geometric average of utilizing research patient colony of institute _(0-∞)Value, this AUC _(0-∞)Value is at research patient colony value, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.In certain embodiments, system and method as herein described provide routine than administration under the same conditions can suck corticosteroid treatment increase at least about 4-6 doubly, about 4-5.75 doubly, about 4-5.5 doubly, about 4-5.25 doubly, about 4-5 doubly, the corticosteroid plasma A UC of about 4.5-6 times, about 4.75-6 times, about 5-6 times, about 5.5-6 times _(0-∞)Value, this AUC _(0-∞)Value is at research patient colony value, and the corticosteroid dosage of the corticosteroid that gives at every microgram carries out standardization.

In some embodiments, the AUC that provides of the described method and system that is used at patient treatment that needs are arranged or prevention bronchus constriction obstacle _(0-∞)Can be significantly can suck the shown plasma A UC of suspension greater than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _(0-∞)Value.In certain embodiments, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)About 1.5 times of (150%)-10 times (1000%) of value.In one embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 1000% (10 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)About 900% (9 times)-1000% (10 times), about 925% (9.25 times)-1000% (10 times), about 950% (9.5 times)-1000% (10 times) of value.In another embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 900% (9 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 800% (8 times)-900% (9 times), about 825% (8.25 times)-900% (9 times) or about 850% (8.5 times)-900% (9 times).In the another embodiment that also has, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 800% (8 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 700% (7 times)-800% (8 times), about 725% (7.25 times)-800% (8 times) or about 750% (7.5 times)-800% (8 times).In the another embodiment that still also has, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 700% (7 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 600% (6 times)-700% (7 times), about 625% (6.25 times)-700% (7 times) or about 650% (6.5 times)-700% (7 times).In one embodiment, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 600% (6 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 500% (5 times)-600% (6 times), about 525% (5.25 times)-600% (6 times) or about 550% (5.5 times)-600% (6 times).In another embodiment, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 500% (5 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 400% (4 times)-500% (5 times), about 425% (4.25 times)-500% (5 times) or about 450% (4.5 times)-500% (5 times).In the another embodiment that also has, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 400% (4 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 300% (3 times)-400% (4 times), about 325% (3.25 times)-400% (4 times) or about 350% (3.5 times)-400% (4 times).In the another embodiment that also has, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 300% (3 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 200% (2 times)-300% (3 times), about 225% (2.25 times)-300% (3 times) or about 250% (2.5 times)-300% (3 times).In the another embodiment that still also has, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 200% (2 times).At some in other the embodiment, AUC _(0-∞)Can be to suck the shown plasma A UC of suspension with the routine that contains corticosteroid of identical nominal dosed administration under the same conditions _(0-∞)The value at least about 150% (1.5 times)-200% (2 times).In another embodiment, AUC _(0-∞)Be the AUC that contains the sucked suspension of corticosteroid _(0-∞)At least about 150% (1.5 times).

In some embodiments, AUC _(0-∞)The routine that can be equivalent to contain corticosteroid basically can suck the shown plasma A UC of suspension _(0-∞)Value, wherein, described moisture suction mixture is with lower nominal dosage administration under the same conditions.In one embodiment, the ratio that described nominal dosage and the routine that contains corticosteroid can suck the nominal dosage of suspension can be about 1:1.5 (promptly, 1.5 doubly enhanced PK (pharmacokinetic) profile)-1:10 (that is 10 times of enhanced PK (pharmacokinetic) profile).In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that has again, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In certain embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other the embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension at some.In other some embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:10 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.

E. the blood plasma T of Jiang Diing _MaximumValue

As herein described being used for can be delivered to the experimenter with corticosteroid in the following manner at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, the active substance that is transferred has than the blood plasma T that can suck the reduction of corticosteroid suspension under the same conditions with the routine of same dose administration _MaximumValue.In a kind of example, utilize Pari LC

Blast atomizer is with the volume of 2.0ml, about 5 minutes administration time, and the PK (pharmacokinetic) profile that shows with the conventional budesonide suspension of single dose administration makes that nominal dosage is the blood plasma T of 500-1000 μ g _MaximumValue is respectively about 0.24 ± 0.25 (h)-0.23 ± 0.24 (h).Use system and method as herein described, utilize Pari eFlow

Carrying 0.5ml name dosage with single dose in about 1.5 minutes time of deliveries is budesonide+SBE7-β-CD of 60 μ g, 120 μ g and 240 μ g when sucking solution, blood plasma T _MaximumValue is respectively about 0.11 ± 0.09 (h), 0.11 ± 0.09 (h) and 0.21 ± 0.24 (h).

In second example, utilize Pari LC

Blast atomizer gives conventional budesonide suspension (Pulmicort with the volume of 2.0ml in about 4 minutes administration times

), one day twice, continue 7 days, the PK (pharmacokinetic) profile of its demonstration is as follows: for nominal dosage is the budesonide of 250 μ g, blood plasma T _MaximumMeansigma methods is 0.22 ± 0.22 (h), minimum blood plasma T _MaximumValue is about 0.08 (h), maximum blood plasma T _MaximumValue is about 0.75 (h); For nominal dosage is the budesonide of 500 μ g, blood plasma T _MaximumMeansigma methods is about 0.19 ± 0.19 (h), minimum blood plasma T _MaximumValue is about 0.08 (h), maximum blood plasma T _MaximumValue is about 0.75 (h).Use system and method as herein described, utilize Pari eFlow

In about 1.5 minutes time of deliveries, carry 60 μ g CBIS to suck solution with the volume of 0.5ml, one day twice, continue 7 days, minimum blood plasma T _MaximumValue is about 0.08 (h), maximum blood plasma T _MaximumValue is about 0.25 (h), T _MaximumMeansigma methods is about 0.11 (h).Similarly, utilize Pari eFlow

In about 1.5 minutes time of deliveries, carry 120 μ g CBIS to suck solution with the volume of 0.5ml, one day twice, continue 7 days, minimum blood plasma T _MaximumValue is about 0.08 (h), maximum blood plasma T _MaximumValue is about 0.50 (h), T _MaximumMeansigma methods is about 0.14 (h).Fig. 5 provides above-mentioned blood plasma T _MaximumThe graphic representation of the data of value institute foundation.

Therefore, the T that provides of the described method and system that is used at patient treatment that needs are arranged or prevention bronchus constriction obstacle _MaximumThe routine that contains corticosteroid that can be significantly less than under the same conditions with identical nominal dosed administration can suck the blood plasma T that suspension shows _MaximumValue.In some embodiments, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumBe worth little at least about 1.5-10 times.In certain embodiments, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumBe worth little at least about 8 times.In some other embodiment, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumBe worth little at least about 6 times.In a kind of such embodiment, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumBe worth little at least about 4 times.In another embodiment, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumBe worth little at least about 3 times.In the another embodiment that also has, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumValue is soon at least about 2 times.In the another embodiment that still also has, T _MaximumCan suck the blood plasma T that suspension shows than the routine that contains corticosteroid with identical nominal dosed administration under the same conditions _MaximumValue is soon at least about 1.5 times.

In some embodiments, T _MaximumCan suck the blood plasma T that suspension shows less than the routine that contains corticosteroid _MaximumValue, wherein, described moisture suction mixture is with lower nominal dosage administration under the same conditions.In one embodiment, the ratio that described nominal dosage and the routine that contains corticosteroid can suck the nominal dosage of suspension can be about 1:1.5 (promptly, 1.5 doubly enhanced PK (pharmacokinetic) profile)-1:10 (that is 10 times of enhanced PK (pharmacokinetic) profile).In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that has again, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:1.5-1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In another embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In the another embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2-1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In certain embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:2 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other the embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:3 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension at some.In other some embodiment, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:4 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:5 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:6 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:7 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiments, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:8 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:9 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.In other embodiment that still also has, the described nominal dosage that contains the moisture suction mixture of corticosteroid can be about 1:10 with the ratio that the routine that contains corticosteroid can suck the nominal dosage of suspension.

XIII. the dosage that is used for the treatment of method and system

Be used for the moisture suction mixture that comprises corticosteroid such as budesonide and solubility enhancing agent to be delivered to the experimenter in one way at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, according to good medical practice, consider the clinical condition of single patient, position and method, the plan of administration and the known other factors of doctor of obtaining employment of administration, carry active matter.In people's treatment, the method that the present invention describes can be carried the corticosteroid solutions of keeping treatment effective dose corticosteroid such as budesonide, for example budesonide solution reducing or alleviate the related indication action site of bronchus constriction obstacle.In other embodiments, described moisture suction mixture comprises corticosteroid and solubility enhancing agent, and wherein this suction mixture is gone up the active medicine that does not contain except that the cortex steroid substantially.

In other embodiments, be used for the moisture suction mixture that comprises corticosteroid such as budesonide, solvent and solubility enhancing agent to be delivered to the experimenter in one way at the method and system of patient's treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, according to good medical practice, consider the clinical condition of single patient, position and method, the plan of administration and the known other factors of doctor of obtaining employment of administration, carry active matter.In people's treatment, the method that the present invention describes can be carried the corticosteroid solutions of keeping treatment effective dose corticosteroid such as budesonide, for example budesonide solution reducing or alleviate the related indication action site of bronchus constriction obstacle.In other embodiments, described moisture suction mixture comprises corticosteroid, solvent and solubility enhancing agent, and wherein this suction mixture is gone up the active medicine that does not contain except that the cortex steroid substantially.

In the various embodiments of the method and system of in above-mentioned XII part, describing, be used for can being delivered to the experimenter by sucking nebulizer will contain the corticosteroid for the treatment of effective dose with following nominal dosage moisture suction mixture at the method and system of patient treatment that needs are arranged or prevention bronchus constriction obstacle, described nominal dosage is about 15 μ g/ dosage-less than about 250 μ g/ dosage, or about 25-240 μ g/ dosage, or about 200-240 μ g/ dosage, or about 125-200 μ g/ dosage, or about 150-200 μ g/ dosage, or about 100-150 μ g/ dosage, or about 100-125 μ g/ dosage, or about 50-125 μ g/ dosage, or about 60-125 μ g/ dosage, or about 25-50 μ g/ dosage.In preferred embodiments, corticosteroid is the budesonide that gives the experimenter by the suction nebulizer with the nominal dosage of about 25-240 μ g/ dosage.In one embodiment, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is to arrive less than the nominal dosed administration of the corticosteroid of about 250 μ g/ dosage with about 60 μ g/ dosage according to method and system as herein described.In another embodiment, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is with the corticosteroid name dosed administration less than about 250 μ g/ dosage according to method and system as herein described.In the another embodiment that also has, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 240 μ g/ dosage.In the another embodiment that has again, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 125 μ g/ dosage.In the another embodiment that also has, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 120 μ g/ dosage.In the another embodiment that still also has, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 60 μ g/ dosage.In the another embodiment that also has, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 40 μ g/ dosage.In certain embodiments, described moisture suction mixture contains single corticosteroid and is substantially devoid of pharmaceutically active agent except that described corticosteroid.

In certain embodiments, be used for to be delivered to the experimenter by sucking nebulizer with the moisture suction mixture of about 25 μ g/ dosage-will contain the corticosteroid for the treatment of effective dose less than the nominal dosage of about 100 μ g/ dosage at the method and system of patient treatment that needs are arranged or prevention bronchus constriction obstacle, wherein, described corticosteroid is selected from the corticosteroid in the aforementioned paragraphs but does not comprise betamethasone.In a kind of such embodiment, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is with the corticosteroid name dosed administration less than about 100 μ g/ dosage according to method and system as herein described.In another embodiment, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 60 μ g/ dosage.In the another embodiment that also has, described moisture suction mixture comprises corticosteroid such as budesonide, and wherein said moisture suction mixture is according to the corticosteroid name dosed administration of method and system as herein described with about 40 μ g/ dosage.In certain embodiments, described moisture suction mixture contains single corticosteroid and is substantially devoid of pharmaceutically active agent except that described corticosteroid.

But in some embodiments of composition for inhalation as herein described or moisture suction mixture, but described composition for inhalation or moisture suction mixture comprise solvent.In certain embodiments, described solvent is selected from water, aqueous alcohol, propylene glycol, or water-containing organic solvent.In preferred embodiments, described solvent is a water.

In some embodiments of the method and system that the present invention describes, use the moisture suction mixture that contains corticosteroid, this mixture also contains solubility enhancing agent.In some embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.001%-25%.In other embodiments, described solubility enhancing agent can have the concentration (w/v) of about 0.01%-20%.In other embodiment that also has, described solubility enhancing agent can have the concentration (w/v) of about 0.1%-15%.In other embodiment that has again, described solubility enhancing agent can have the concentration (w/v) of about 1%-10%.In preferred embodiments, when described solubility enhancing agent be cyclodextrin or cyclodextrin derivative such as SBE7-β-CD

In certain embodiments, described moisture suction mixture comprises solubility enhancing agent, and this solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD

In yet another aspect, the described moisture suction mixture that contains corticosteroid is according to method and system administration as herein described, is no more than twice in one day (b.i.d).Also have another aspect, described moisture suction mixture contains corticosteroid such as budesonide, wherein, described moisture suction mixture is according to method and system administration as herein described, one day twice.Have again another aspect, described moisture suction mixture contains corticosteroid such as budesonide, wherein, described moisture suction mixture is according to method and system administration as herein described, one day is no more than once.In another embodiment that also has, described moisture suction mixture contains corticosteroid such as budesonide, and wherein, described moisture suction mixture is according to method and system as herein described administration at night, and one day is no more than once.

In certain embodiments, method and system of the present invention also comprises and will contain moisture suction mixture and one or more activating agents combination administration of corticosteroid.In some embodiments, corticosteroid such as budesonide can make up administrations with one or more other medicines, one or more activating agents, and described activating agent is selected from: (a) beta 2-adrenergic receptor agonist; (b) dopamine (D2) receptor stimulating agent; (c) prophylactic treatment agent is as steroid; (d) local anesthetic; Or (e) anticholinergic; But with composition for inhalation provided herein simultaneously or before or after give.

The example of combination of activating agent that can be used for the inventive method and system is as follows.

The beta 2-adrenergic receptor agonist that is used for being used in combination with compositions provided by the invention includes but not limited to albuterol, and (α-1-(((1, the 1-dimethyl ethyl) methyl amino))-4-hydroxyl-1, the 3-benzene dimethanol), ((2-((1 for dimethylamino formic acid 5-for bambuterol (Bambuterol), the I-dimethyl ethyl) amino)-and the 1-ethoxy)-1,3-phenylene ester), ((2-((1 for 4-benzoin methyl acid 4-for bitolterol (Bitolterol), the 1-dimethyl ethyl) amino)-and the 1-ethoxy)-1,2-phenylene ester), broxaterol (Broxaterol) (3-bromo-α-(((1, the 1-dimethyl ethyl) methyl amino))-5-isoxazole methanol), isonorin (4-(1-hydroxyl-2-((1-Methylethyl-) amino) ethyl)-1,2-benzene-glycol), Trimetoquinol (1,2,3,4-tetrahydrochysene-1-((3,4-, the 5-trimethoxyphenyl)-and methyl)-6,7-isoquinolin glycol (isoquinolinediol)), Clenbuterol (Clenbuterol) (4-amino-3,5-two chloro-α-(((1, the 1-dimethyl ethyl) benzyl alcohol methyl amino))), fenoterol (Fenoterol) (5-(1-hydroxyl-2-((2-(4-hydroxyphenyl)-1-Methylethyl) amino) ethyl)-1, the 3-Benzenediol), formoterol (Formoterol) (2-hydroxyl-5-((1RS)-1-hydroxyl-2-(((1RS)-2-(right-methoxyphenyl)-1-Methylethyl) amino) ethyl) formanilide), (R, R)-formoterol, Desformoterol ((R, R) or (S, S)-3-amino-4-hydroxy-α-(((2-(4-methoxyphenyl)-1-methyl-ethyl) amino) methyl) phenyl methanol), Hexoprenaline (Hexoprenaline) (4,4 '-(1,6-hexane-two base (diyl))-two (imino group (1-hydroxyls-2,1-second two bases (ethanediyl)))) two-1, the 2-Benzenediol), neoisuprel (Isoetharine) (4-(1-hydroxyl-2-((1-Methylethyl) amino) butyl)-1, the 2-Benzenediol), isoproterenol (lsoprenaline) (4-(1-hydroxyl-2-((1-Methylethyl) amino) ethyl)-1, the 2-Benzenediol), Meta-proterenol (5-(1-hydroxyl-2-((1-Methylethyl) amino) ethyl)-1, the 3-Benzenediol), Picumeterol (4-amino-3,5-two chloro-α-(((6-(2-(2-pyridine radicals) ethyoxyl) hexyl)-amino) methyl) benzyl alcohol), (α-6-(((1 for pirbuterol (Pirbuterol), the 1-dimethyl ethyl)-and amino) methyl)-3-hydroxyl-2, the 6-piconol, procaterol (Procaterol) (((R*, S*)-(+-)-8-hydroxyl-5-(1-hydroxyl-2-((1-Methylethyl) amino) butyl)-2 (1H)-quinolinones (quinolin-one)), (((((2-(3 for 3-for 7-for reproterol (Reproterol), the 5-dihydroxyphenyl)-and the 2-ethoxy) amino)-propyl group)-3,7-dihydro-1,3-dimethyl-1H-purine-2, the 6-diketone), rimiterol (Rimiterol) (4-(hydroxyl-2-piperidino methyl)-1, the 2-Benzenediol), albuterol (Salbutamol) ((+-)-α-(((1, the 1-dimethyl ethyl) methyl amino))-4-hydroxyl-1, the 3-benzene dimethanol), (R)-albuterol, salmaterol (Salmeterol) ((+-)-4-hydroxyl-α-1-(((6-(4-phenyl butoxy) hexyl)-amino) methyl)-1, the 3-benzene dimethanol), (R)-salmaterol, ((2-((1 for 5-for terbutaline (Terbutaline), the 1-dimethyl ethyl) amino)-and the 1-ethoxy)-1, the 3-Benzenediol), tulobuterol (Tulobuterol) (2-chloro-α-(((1, the 1-dimethyl ethyl) methyl) benzyl alcohol) and TA-2005 (8-hydroxyl-5-((1R)-1-hydroxyl-2-(N-((1R)-2-(4-methoxyphenyl)-1-Methylethyl) amino) ethyl) 2-hydroxyquinoline hydrochlorate).

Dopamine (D2) receptor stimulating agent includes but not limited to apomorphine (Apomorphine) ((r)-5,6,6a, 7-tetrahydrochysene-6-methyl-4H-dibenzo [de, g1 quinoline-10, the 11-glycol), bromocriptine (Bromocriptine) ((5 ' α)-2-bromo-12 '-hydroxyl-2 '-(1-Methylethyl)-5 '-(2-methyl-propyl) Ergotamine (ergotaman)-3 ', 6 ', the 18-triketone), cabergoline (Cabergoline) ((8-β)-N-(3-(dimethylamino) propyl group)-N-((ethylamino) carbonyl-1)-6-(2-acrylic) ergoline-8-Methanamide); Lisuride (Lisuride) (N '-((8-α)-9,10-two dehydrogenations-6-methyl ergoline-8-yl)-N, the N-diethyl urea), pergolide (Pergolide) ((8-β-)-8-((methyl mercapto) methyl)-6-pergolide), levodopa (3-hydroxyl-L-tyrosine (tryrosine)), pramipexole (Pramipexole) ((s)-4,5,6,7-tetrahydrochysene-N6-propyl group-2, the 6-benzothiazole diamines), quinpirole (Quinpirole) hydrochlorate (trans-(-)-4aR-4,4a, 5,6,7,8,8a, 9-octahydro-5-propyl group-1H-pyrazoles (pyrazolo) [3,4-g] quinoline hydrochloride), ropinirole (Ropinirole) (4-(2-(dipropyl amino) ethyl)-1,3-dihydro-2H-indol-2-one) and talipexole (Talipexole) (5,6,7,8-tetrahydrochysene-6-(2-acrylic)-4H-thiazole [4,5-d] azepine

-2-amine).Other is used for d2 dopamine receptor agonist of the present invention and is disclosed in the open WO 99/36095 of international patent application, and its relevant disclosure is introduced the present invention as a reference.

Other active component that is used for combined therapy of the present invention includes but not limited to the 1L-5 inhibitor, as at United States Patent (USP) 5,668, and 110,5,683,983,5,677,280,6,071, in 910 and 5,654,276 disclosed those, they all introduce the present invention as a reference; As United States Patent (USP) 6,136, the antisense regulator of 603 disclosed IL-5 (anti-sense modulator), their relevant disclosures are introduced the present invention as a reference; Milrinone (milrinone) (1,6-dihydro-2-methyl-6-oxo-[3,4 '-two pyridine]-5-nitrile), milrinone lactate (milrinone lactate); Trypsin inhibitor, as at United States Patent (USP) 5,525, in 623 disclosed those, it is incorporated herein by reference; Tachykinin receptor antagonists, as at United States Patent (USP) 5,691, in 336,5,877,191,5,929,094,5,750,549 and 5,780,467 disclosed those, they all introduce the present invention as a reference; LTRA, as Menglusitena (montelukast sodium) (Singular, R-(E)]-1-[[[1-[3-[2-(7-chloro-2-quinolyl)-vinyl]-phenyl]-3-[2-(I-hydroxyl-1-Methylethyl)-phenyl]-propyl group]-sulfo-]-methyl] cyclopropaneacetic acid (cyclopro-paneacetic acid), single sodium salt), 5-lipoxidase (Iypoxygenase) inhibitor, as zileuton (zileuton) (

, Abbott Laboratories, Abbott Park, IL) and anti--IgE antibody, as Xolair (recombinant humanized is anti--(CGP 51901 for the IgE monoclonal antibody; IGE 025A; RhuMAb-E25), Genentech, Inc., South San Francisco, CA), and local anesthetic, as lignocaine, N-aryl amide, aminoalkyl benzoate, prilocaine (prilocaine), etidocaine (etidocaine) (United States Patent (USP) 5,510,339,5,631,267 and 5,837,713, their relevant disclosure is introduced the present invention as a reference).

XIV. the using method that comprises the moisture suction mixture of corticosteroid

The method and system of describing in the above-mentioned XII of this paper part of the present invention can carry the moisture mixture that sucks that comprises corticosteroid such as budesonide to the experimenter with the treatment effective dose, with treatment have or expect the asthma of being selected from is arranged, the experimenter of the bronchus constriction obstacle of infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema or above-mentioned disease combination in any.In one embodiment, described bronchus constriction obstacle is an infantile asthma.In another embodiment, described bronchus constriction obstacle is a bronchial asthma.In also having another embodiment, described bronchus constriction obstacle is chronic obstructive pulmonary disease (COPD).

The actual dose level of the moisture suction mixture that comprises corticosteroid that the present invention describes can change, with a certain amount of active component that obtains replying for the topical therapeutic that specific group compound and medication can effectively obtain to expect.Therefore, the duration that selected dosage level depending on the expectation of desired therapeutic effect, treatment and other factors.

XV. pharmacokinetics analysis

The pharmacokinetics scheme of any standard can be used to measure the plasma concentration characteristic of philtrum after the moisture suction solution that the method and system administration of describing by the present invention comprises corticosteroid such as budesonide and solubility enhancing agent, and establishes said preparation thus and whether satisfy pharmacokinetics standard of the present invention.For example, but never be that the randomization single dose cross-reference research of restrictive type can adopt health adult's subject group to carry out.The variation contrast that experimenter's number should be enough to provide enough on the statistical analysis generally is about 8 or more, although for some purpose, less group may be enough.For example, the experimenter accepts the test suction mixture that comprises corticosteroid such as budesonide and solubility enhancing agent of administration single dose (for example 240 μ g) in the time zero.Blood sample is collected from the experimenter in several intervals before administration after (for example 15 minutes) and the administration.For the object of the invention, general preferred several blood samples of in first hour, getting, sampling more continually subsequently.Illustrative ground, blood sample can be after administration be collected in 5,10,20,30,45 and 60 minutes, collected in 2,4,8 and 12 hours after administration then.If identical experimenter is used for the research of test preparation for the second time, then should be before the administration preparation second time through at least 10 days time.By centrifugal from the blood sample separated plasma, isolating blood plasma is used to analyze corticosteroid such as budesonide, described analysis be by the high performance liquid chromatography of having verified/series connection weight spectrum (tandem weight spectrometry) (LC/APCI-MS/MS) method such as, Ramu etc. for example, Journal of Chromatography B, 751:49-59 (2001) carries out.In other embodiments, the data from single experimenter can show enhanced PK (pharmacokinetic) profile.In other embodiment that also has, suitable external model can be used to prove enhanced PK (pharmacokinetic) profile.

Any PK (pharmacokinetic) profile that provides expectation moisture sucks mixture and all is fit to system according to the invention and method and comes administration.The sucked mixture that provides this specific character of exemplary types is the solution that comprises corticosteroid such as budesonide and solubility enhancing agent.

Embodiment

Following composition, method and the step that is used to implement compositions disclosed by the invention, system and method corresponding to above-mentioned those.Following steps have been described the carrying method of the moisture suction mixture that comprises budesonide of the present invention and the specific embodiments of PK (pharmacokinetic) profile thereof.Do not have specifically described method, material or excipient within the scope of the present invention among the following embodiment, with reference to the disclosure of this paper, they are obvious to those skilled in the art.

Embodiment 1

Multiple moisture suction mixture prepares by following method: with commercially available Pulmicort

The content discharging of one or more containers of (1000 μ g budesonide/2mL suspension) is by every milliliter of Pulmicort (volume that is assigned with is 2.1mL) adds 82.5mg (proofreading and correct with water content) (CyDex, Inc., Lenexa, KS, USA), and vortex 5-10 minute.Except budesonide and water, Pulmicort

Also comprise and be considered to inactive following ingredients: citric acid, sodium citrate, sodium chloride, EDTA disodium and polysorbate80.

Embodiment 2

A kind of alternative method as the preparation of embodiment 1 prepares multiple moisture suction mixture by following method: the about 200mg amount of weighing

(CyDex, Inc., Lenexa, KS USA) (proofreaies and correct with water content), adds in the 2 dram amber vial (2-dram amber vials).Comprise in the bottle of weighed amount CAPTISOL to each, by pushing deformable plastic containers slightly to last possible two Pulmicort that turn

The content of container (0.5mg/2mL).With Pulmicort

Vortex is with the budesonide granule that suspends again in advance.Bottle with on the nut cap, is acutely mixed by vortex, wrap up with foil then.This material can Keep cool until use.

Embodiment 3

Table 1 provides the exemplary formulation of the moisture suction mixture that comprises budesonide and solubility enhancing agent that is used for the method for the invention and system.As shown in the table, described moisture suction mixture also can comprise excipient such as antioxidant, stabilizing agent and antiseptic.The amount that is used for the various excipient of described moisture suction mixture is with respect to dosage to be administered, and can easily be determined by those of ordinary skills.

Table 1

Raw material (mg)	1％ DM-β-CD	5％ DM-β-CD	7％ DM-β-CD	5％ DM-β-CD	5％ DM-β-CD
Raw material (mg)	1％ DM-β-CD	5％ DM-β-CD	7％ DM-β-CD	5％ DM-β-CD	5％ DM-β-CD	Budesonide	0.024	0.024	0.024	0.006	0.012
Dimethyl-β-CD	1.0	5.0	7.0	5.0	5.0	Budesonide	0.024	0.024	0.024	0.006	0.012
Dimethyl-β-CD	1.0	5.0	7.0	5.0	5.0	Citric acid	0.045	0.045	0.045	0.045	0.045
Sodium chloride	0.850	0.850	0.850	0.850	0.850	Citric acid	0.045	0.045	0.045	0.045	0.045
Sodium chloride	0.850	0.850	0.850	0.850	0.850	Disodiumedetate	0.05	0.05	0.05	0.05	0.05
Water	Add to 100.0	Add to 100.0	Add to 100.0	Add to 100.0	Add to 100.0	Disodiumedetate	0.05	0.05	0.05	0.05	0.05

Embodiment 4

Table 2 provides the exemplary formulation of the moisture suction mixture that comprises budesonide and solubility enhancing agent that is used for the method for the invention and system.As shown in the table, described moisture suction mixture also can comprise excipient such as antioxidant, stabilizing agent and antiseptic.The amount that is used for the various excipient of described moisture suction mixture is with respect to dosage to be administered, and can easily be determined by those of ordinary skills.

Table 2

Raw material (mg)	1％ HP-β-CD	5％ HP-β-CD	7％ HP-β-CD	5％ HP-β-CD	5％ HP-β-CD
Raw material (mg)	1％ HP-β-CD	5％ HP-β-CD	7％ HP-β-CD	5％ HP-β-CD	5％ HP-β-CD	Budesonide	0.024	0.024	0.024	0.006	0.012
HP-β-CD	1.0	5.0	0.7	5.0	5.0	Budesonide	0.024	0.024	0.024	0.006	0.012
HP-β-CD	1.0	5.0	0.7	5.0	5.0	Citric acid	0.045	0.045	0.045	0.045	0.045
Sodium chloride	0.850	0.850	0.850	0.850	0.850	Citric acid	0.045	0.045	0.045	0.045	0.045
Sodium chloride	0.850	0.850	0.850	0.850	0.850	Disodiumedetate	0.05	0.05	0.05	0.05	0.05
Water	Add to 100.0	Add to 100.0	Add to 100.0	Add to 100.0	Add to 100.0	Disodiumedetate	0.05	0.05	0.05	0.05	0.05

Embodiment 5

Table 3 has been described and has been comprised budesonide and Pulmicort

Moisture suction mixture dosage and be used to carry the atomizer device of described dosage to lung.Administration A-C is by diluting preparation in the following manner with 0.9% (w/w) saline by the moisture suction mixture of embodiment 1 described preparation: administration A is with the dilution proportion of 0.9% (w/w) saline with 25:75; Administration B is with the dilution proportion of 0.9% (w/w) saline with 50:50; C does not dilute with administration.With budesonide+SBE7-β-CD

Suck solution Pari eFlow

Carry with 0.5ml volume and about 1.5 minutes time of delivery.Described Pari eFlow

Being equipped with size is 30 purpose films and undersized aerosol chamber.With described Pulmicort

Use Pari LC

Blast atomizer gives with 2.0ml volume and about 5 minutes administration time.

Table 3

Embodiment 6

By being carried out γ scitiphotograph analysis (gammascintigraph analysis) before and after the atomized medicine introducing dosage form, the experimenter carries out clinical evaluation.The purpose of this research is to measure the budesonide suspension or have in the lung of the radiolabeled budesonide in solution spray treatment back of solubility enhancing agent by the γ scitiphotograph to deposit.

Table 4 general description relate to the data of the lung deposition percent of the administration A-C that carries by the described methods of embodiment 5.Lung deposition percent is all meansigma methodss of being estimated the experimenter, and definite by the quantification of scitiphotograph data that each administration is got.But Fig. 1 shows the total lung deposition of the composition for inhalation that comprises budesonide and the percent of oropharyngeal deposition.Fig. 2 shows the total lung deposition from the budesonide of scitiphotograph data.

Table 4

Administration	Target dose (μ g)	True nominal dosage (μ g)	Gauged lung dosage (μ g)	Lung deposition percent
Administration	Target dose (μ g)	True nominal dosage (μ g)	Gauged lung dosage (μ g)	Lung deposition percent	A	60	60.69±1.95	21.72±4.81	35.7
B	120	121.16±4.29	49.26±10.13	40.6	A	60	60.69±1.95	21.72±4.81	35.7
B	120	121.16±4.29	49.26±10.13	40.6	C	240	234.85±2.74	88.13±14.93	37.5

Embodiment 7

Table 5 general description the PK (pharmacokinetic) profile of carrying budesonide after the administration A-E as single dose as described in the embodiment 5.Eight (8) healthy males are used for this clinical research, and value given below is the meansigma methods of each pharmacokinetic parameter of recording during clinical research.Fig. 4 provides the graphic representation of the data of the PK (pharmacokinetic) profile that is used to produce administration A-E.

Table 5

Embodiment 8

Table 6 provides the dosage (details are as follows) of the research medicine that is used for embodiment 8 described clinical researches.Described research medicine comprises suction

Budesonide sucks two kinds of test preparations (treatment A and B) of solution (CBIS) and the budesonide suspension (Pulmicort that sucks Two kinds with reference to preparation (treatment C and D), and be used to carry the atomizer device of described research medicine to lung.

Table 6

Test and be described in detail in the table 7 with reference to each component of preparation.

Table 7

Embodiment 9

Table 8 general description after relating to single center as embodiment 8 described administration A-D, double blinding, multiple dose, parallel group, placebo, the cross-reference research of two phases the PK (pharmacokinetic) profile of budesonide.48 (48) healthy male volunteers are used for this clinical research.With each experimenter's random packet that suitable lattice should be studied, accept one of following treatment: treatment A (60 μ g CBIS solution), treatment B (120 μ g CBIS solution), treatment C (250 μ g Pulmicort

Suspension (250 μ g Pulmicort)), treatment D (500 μ g Pulmicort

Suspension (500 μ g Pulmicort)).The experimenter receives treatment A, B, C or D every day twice, continues 7 days.Each experimenter accepts active medicine and placebo during two research.Table 8 provides the value of each pharmacokinetic parameter that records in the administration of research treatment A-D during clinical research.

Table 8

Dosage	The statistics general introduction	C _Maximum (pg/ml)	T _Maximum(h)	AUC _{(at last)}(pg/ml.h)	AUC _(0-INF)(pg/ml.h)	t _1/2(h)
Dosage	The statistics general introduction	C _Maximum (pg/ml)	T _Maximum(h)	AUC _{(at last)}(pg/ml.h)	AUC _(0-INF)(pg/ml.h)	t _1/2(h)	Treatment A (60 μ g CBIS)	N meansigma methods SD minima median maximum CV (%) geometrical mean	12 402.001 192.549 186.370 378.730 779.340 47.898 362.202	12 0.117 0.058 0.08 0.08 0.25 N/A N/A	12 310.861 95.652 106.380 317.000 463.070 30.800 293.699	12 424.875 157.589 156.520 409.780 748.450 37.100 396.119	12 2.4860 2.9550 0.7000 1.6800 11.7200 118.90001.8370
Treatment B (120 μ gCBIS)	N meansigma methods SD minima median maximum CV (%) geometrical mean	11 625.337 357.439 169.800 735.280 1160.440 57.159 516.991	11 0.14 0.13 0.08 0.08 0.50 N/A N/A	11 726.658 417.236 168.220 576.370 1496.720 57.400 621.429	11 860.632 464.844 221.420 740.700 1863.680 54.000 752.164	11 2.4270 0.9530 1.5000 1.9800 4.4000 39.30002.2840	Treatment A (60 μ g CBIS)		12 402.001 192.549 186.370 378.730 779.340 47.898 362.202	12 0.117 0.058 0.08 0.08 0.25 N/A N/A	12 310.861 95.652 106.380 317.000 463.070 30.800 293.699	12 424.875 157.589 156.520 409.780 748.450 37.100 396.119	12 2.4860 2.9550 0.7000 1.6800 11.7200 118.90001.8370
Treatment B (120 μ gCBIS)		11 625.337 357.439 169.800 735.280 1160.440 57.159 516.991	11 0.14 0.13 0.08 0.08 0.50 N/A N/A	11 726.658 417.236 168.220 576.370 1496.720 57.400 621.429	11 860.632 464.844 221.420 740.700 1863.680 54.000 752.164	11 2.4270 0.9530 1.5000 1.9800 4.4000 39.30002.2840	Treatment C (250 μ g Pulmicort)	N meansigma methods SD minima median maximum CV (%) geometrical mean	11 319.673 185.337 107.450 231.560 574.720 57.977 270.563	11 0.22 0.22 0.08 0.08 0.75 N/A N/A	11 361.162 212.378 78.570 318.120 803.030 58.800 302.632	11 472.314 239.042 148.720 425.030 920.020 50.600 413.000	11 2.0230 0.9370 0.9100 1.7600 4.3200 46.30001.8600

Treatment D (500 μ g Pulmicort)

N meansigma methods SD minima median maximum CV (%) geometrical mean

12 491.398207.942 199.390 474.310963.250 42.316 451.661

12 0.1860.193 0.08 0.08 0.75 N/A N/A

12 811.145 328.022 236.220 856.320 1224.800 40.400 735.111

12 945.718 363.252 381.480 952.860 1454.800 38.400 874.697

12 2.4930 0.7700 1.2100 2.4600 3.6600 30.90002.3720

Embodiment 10

Embodiment 3 and 4 described moisture suction mixture are delivered to patient colony according to embodiment 5 described methods.Equally according to embodiment 5 described method administration Pulmicort

With Pulmicort

PK (pharmacokinetic) profile compare, the PK (pharmacokinetic) profile of described moisture suction solution can show enhanced pharmacokinetic parameter.For example, with Pulmicort

Compare, described moisture suction solution can show bigger C _Maximum, AUC ₍ _{The back)}, AUC _(0-∞)Value and/or lower T _MaximumValue.Equally, if with Pulmicort with lower dosed administration

Compare, described moisture suction solution can show identical C _Maximum, AUC ₍ _{The back)}And AUC _(0-∞)Value.

Embodiment 11

Embodiment

1 and 2 described moisture suction mixture are delivered to patient colony according to embodiment 5 described methods.According to embodiment 5 described method administration name dosage is to the Pulmicort that is up to 2500 μ g/ dosage from 1000 μ g/ dosage

With Pulmicort

PK (pharmacokinetic) profile compare, the PK (pharmacokinetic) profile of described moisture suction solution can show enhanced pharmacokinetic parameter.For example, described moisture suction solution can show with Essentially identical C _Maximum, AUC _{(at last)}, AUC _(0-∞)Value is even nominal dosage to be administered is lower in fact.

Embodiment 12

The preparation and the purposes that comprise the moisture suction mixture of corticosteroid, solubility enhancing agent and salbutamol sulfate or Levalbuterol hydrochloride (Xopenex).

Preparation citrate buffer as described below (3mM pH4.5).The citric acid of about 62.5mg is dissolved in the volumetric flask of a 100ml, and water transfers to volume.The sodium citrate of about 87.7mg is dissolved in the volumetric flask of another 100ml, and water transfers to volume.In beaker, sodium citrate solution is added in the citric acid solution, be about 4.5 until pH.

With about 10.4mg budesonide and 1247mg

(CyDex Inc.) grinds with pestle with mortar and is in the same place, and is transferred in the 10mL beaker.Add buffer agent solution,, and add other 1.4mg budesonide mixture vortex, supersound process.After the shaken over night, solution is filtered by 0.22 μ m Durapore Millex-GV Millipore syringe filtering device.Gained budesonide concentration is about 1mg/ml.About 0.5ml budesonide solution is joined

(2.5mg/3mL) or

In the unit dose (1.25mg/3mL), form the transparent moisture suction mixture that is applicable to embodiment 5 described suction nebulizers thus.

Embodiment 13

The preparation and the purposes that comprise the moisture suction mixture of corticosteroid, solubility enhancing agent and Fu Moteluo (formoterol)

(fumaric acid Fu Moteluo sucks powder)).

The capsular content turned letter of a fumaric acid Fu Moteluo who is mixed with the 25mg lactose who comprises 12 μ g to a bottle, is added the 3mM citrate buffer (pH4.5) of 3mL as preparation as described in the embodiment 12 in bottle.The content of vortex bottle, the solid that exists with dissolving.As preparation budesonide concentrate as described in the embodiment 9, provide the concentration of 1mg/mL.

About 1mL budesonide solution is joined in the fumaric acid Fu Moteluo buffer solution.Mixture is the transparent moisture suction mixture that is applicable to embodiment 5 described suction nebulizers.

Embodiment 14

Embodiment 12 and 13 described moisture suction mixture are delivered to patient colony according to embodiment 5 described methods.Equally according to embodiment 5 described method administration Pulmicort

With Pulmicort PK (pharmacokinetic) profile compare, the PK (pharmacokinetic) profile of described moisture suction mixture can show enhanced pharmacokinetic parameter.For example, if with Pulmicort with identical nominal dosed administration

Compare, described moisture suction solution can show bigger C _Maximum, AUC _{(at last)}, AUC _(0-∞)Value and/or lower T _MaximumValue.Equally, if with Pulmicort with lower nominal dosed administration

Compare, described moisture suction solution can show identical C _Maximum, AUC _{(at last)}And AUC _(0-∞)Value.

Embodiment 15

The traditional cascade impactor that uses the granular size in vitro tests to use is all observed following deposition characteristics for budesonide solution and Pulmicort Respule suspension.Described budesonide solution is atomized with PARI eFlow equipment.Described Pulmicort Respule suspension is atomized with PARI LCPlus nebulizer.Utilize the sedimentary different definition of lung (level 3-7, level 4-7, level 5-7), these results are further transformed with the lung deposition efficiency as the level range function, as shown in table 9.Table 10 shows, depends on the used level scope of lung deposition (level 3-7, level 4-7, level 5-7), and lung deposition (being expressed as the sedimentary ratio of eFlow/Pari LC Plus) is respectively from 1.2,1.9 to 3.8 for level 3-7, level 4-7, level 5-7.Fine fraction is defined as granular size less than 4.7 μ m (Bosco AP etc., In Vitro Estimation of In Vivo Jet NebulizerEfficiency Using Actual and Simulated Tidal Breathing Patterns, Journal of Aerosol Medicine 18 (4): 427-38 (2005); Its full content is incorporated herein by reference).

Claims

1. the method for treatment or prevention bronchus constriction obstacle in the patient who needs is arranged, this method comprises:

(a) provide a kind of moisture suction mixture that comprises single corticosteroid and solubility enhancing agent; With

(b) carry described moisture suction mixture with the suction nebulizer,

Wherein, described corticosteroid is gone up the pharmaceutically active agents that does not contain except that single corticosteroid substantially with the nominal dosed administration and the wherein said suction mixture that are less than about 125 μ g/ dosage.

2. the process of claim 1 wherein that the volume of described moisture suction mixture is about 0.5mL, about 1.0mL, about 1.5mL, about 2.0mL, about 2.5mL, about 3.0mL or about 3.5mL.

3. any one method among the claim 1-2, wherein said nebulizer be selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

4. any one method among the claim 1-3, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic bronchitis and emphysema.

5. any one method among the claim 1-4, the time of delivery of wherein said method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.

6. any one method among the claim 1-4, wherein all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

7. the process of claim 1 wherein that the administration of described suction mixture was no more than once in one day.

8. the process of claim 1 wherein that the administration of described suction mixture is for once a day.

9. the process of claim 1 wherein that the administration of described suction mixture was no more than twice in one day.

10. the process of claim 1 wherein that the administration of described suction mixture is one day twice.

11. the method for claim 7, the administration at night of wherein said suction mixture.

12. any one method among the claim 1-11, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

13. method according to claim 1, wherein said solubility enhancing agent comprises SBE7-β-CD.

14. method according to claim 1, wherein said solubility enhancing agent comprise about 2%, about 5%, about 7% or SBE7-β-CD of about 10%w/v.

15. according to any described method among the claim 1-14, wherein said nominal dosage is less than about 125 μ g/ dosage.

16. according to any described method among the claim 1-14, wherein said nominal dosage is about 120 μ g/ dosage.

17. according to any described method among the claim 1-14, wherein said nominal dosage is about 60 μ g/ dosage.

18. a method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises:

(a) provide a kind of single corticosteroid of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising; With

(b) carry described moisture suction mixture with the suction nebulizer,

Thus, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage corticosteroid is compared with comprising of administration under the same conditions, described method provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of the single corticosteroid of nominal dosage of twice to go up the pharmaceutically active agents that does not contain except that described corticosteroid substantially.

19. the method for claim 18, the nominal dosage of single corticosteroid is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension in the wherein said moisture suction mixture.

20. according to claim 18 or 19 described methods, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises corticosteroid _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the corticosteroid name dosed administration that can suck suspension.

21. the method for claim 20, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.

22. the method for claim 21, the nominal dosage of wherein said moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

23. any one method among the claim 18-22, wherein said nebulizer be selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

24. the method for claim 18 or 20, wherein the local bioavailability of the single corticosteroid of the described moisture suction mixture of being carried by described suction nebulizer is greater than the local bioavailability by the corticosteroid that sucks the sucked suspension that nebulizer carries.

25. any one method among the claim 18-23, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic bronchitis and emphysema.

26. any one method among the claim 18-25, the time of delivery of wherein said method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.

27. any one method among the claim 18-25, wherein all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

28. the method for claim 18 or 20, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

29. method according to claim 28, wherein said solubility enhancing agent comprises SBE7-β-CD.

30. according to claim 18,20 or 23 described methods, wherein said corticosteroid is to be less than the nominal dosed administration of about 250 μ g/ dosage.

31. method according to claim 30, wherein said corticosteroid is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

32. the method for claim 30, wherein said solubility enhancing agent comprises SBE7-β-CD.

33. the method for claim 30, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:4 with the described ratio that sucks the nominal dosage of suspension.

34. an intake system that is used at patient's treatment that needs are arranged or prevention bronchus constriction obstacle, this system comprises:

(a) comprise the single corticosteroid of nominal dosage and the moisture suction mixture of solubility enhancing agent; With

(b) be used to carry the suction nebulizer of described moisture suction mixture,

When giving the single corticosteroid of described patient's name dosage, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage corticosteroid is compared with comprising of administration under the same conditions, described system provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of the single corticosteroid of nominal dosage of twice to go up the pharmaceutically active agents that does not contain except that described single corticosteroid substantially.

35. the intake system of claim 34, the nominal dosage of single corticosteroid is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of corticosteroid in the suspension in the wherein said moisture suction mixture.

36. according to claim 34 or 35 described systems, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises corticosteroid _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the corticosteroid name dosed administration that can suck suspension.

37. the system of claim 36, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.

38. the system of claim 37, the nominal dosage of wherein said moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

39. any one system among the claim 34-38, wherein said nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

40. the system of claim 34 or 36, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

41. according to the described system of claim 40, wherein said solubility enhancing agent comprises SBE7-β-CD.

42. according to claim 34,36 or 39 described systems, the single corticosteroid of wherein said moisture suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.

43. according to the described system of claim 42, the single corticosteroid of wherein said moisture suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

44. a method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises:

(a) provide a kind of moisture suction mixture that comprises budesonide and solubility enhancing agent; With

(b) carry described moisture suction mixture with the suction nebulizer,

Wherein, described budesonide is gone up the pharmaceutically active agents that does not contain except that budesonide substantially with the nominal dosed administration and the wherein said suction mixture that are less than about 250 μ g/ dosage.

45. the method for claim 44, the volume of wherein said moisture suction mixture is about 0.5mL, about 1.0mL, about 1.5mL, about 2.0mL, about 2.5mL, about 3.0mL or about 3.5mL.

46. the method for claim 44 or 45, wherein said nebulizer be selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

47. any one method among the claim 44-46, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic bronchitis and emphysema.

48. any one method among the claim 44-47, the time of delivery of wherein said method is for being less than about 5, about 4, about 3, about 2 or about 1.5 minutes.

49. any one method among the claim 44-47, wherein all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

50. the method for claim 44, the administration of wherein said suction mixture was no more than once in one day.

51. the method for claim 44, the administration of wherein said suction mixture is for once a day.

52. the method for claim 44, the administration of wherein said suction mixture was no more than twice in one day.

53. the method for claim 44, the administration of wherein said suction mixture are one day twice.

54. the method for claim 50, the administration at night of wherein said suction mixture.

55. the method for claim 44, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

56. according to the described method of claim 55, wherein said solubility enhancing agent comprises SBE7-β-CD.

57. according to the described method of claim 56, wherein said solubility enhancing agent comprises about 2%, about 5%, about 7% or SBE7-β-CD of about 10%w/v.

58. according to any described method among the claim 44-57, wherein said nominal dosage is less than about 250 μ g/ dosage.

59. according to the described method of claim 44, wherein said nominal dosage is about 240 μ g/ dosage.

60. according to the described method of claim 44, wherein said nominal dosage is about 120 μ g/ dosage.

61. according to the described method of claim 44, wherein said nominal dosage is about 60 μ g/ dosage.

62. according to the described method of claim 44, wherein said nominal dosage is about 40 μ g/ dosage.

63. a method for the treatment of or preventing bronchus constriction obstacle in the patient who needs is arranged, this method comprises:

(a) provide a kind of budesonide of nominal dosage and moisture suction mixture of solubility enhancing agent of comprising; With

(b) carry described moisture suction mixture with the suction nebulizer,

Thus, compare with the PK (pharmacokinetic) profile of the sucked suspension that comprises budesonide of administration under the same conditions, described method provides at least enhanced PK (pharmacokinetic) profile and the wherein said suction mixture that comprises the moisture suction mixture of nominal dosage budesonide of twice to go up the pharmaceutically active agents that does not contain except that budesonide substantially.

64. the method for claim 63, the nominal dosage of budesonide is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of budesonide in the suspension in the wherein said moisture suction mixture.

65. according to claim 63 or 64 described methods, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises budesonide _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the budesonide name dosed administration that can suck suspension.

66. the method for claim 64, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.

67. the method for claim 66, the nominal dosage of wherein said moisture suction mixture is about 1:4 with the described ratio that sucks the nominal dosage of suspension.

68. any one method among the claim 63-67, wherein said nebulizer be selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

69. the method for claim 63, wherein the local bioavailability of the budesonide of the described moisture suction mixture of being carried by described suction nebulizer is greater than the local bioavailability by the budesonide that sucks the sucked suspension that nebulizer carries.

70. the method for claim 63 or 65, wherein said bronchus constriction obstacle is selected from asthma, infantile asthma, bronchial asthma, allergic asthma, intrinsic asthma, chronic bronchitis and emphysema.

71. the method for claim 63 or 65, the time of delivery of wherein said method is about 5 for being less than, it is about 4 to be less than, it is about 3 to be less than, be less than about 2 or be less than about 1.5 minutes.

72. the method for claim 63 or 65, wherein all basically nominal dosage be less than about 5, be less than about 4, be less than about 3, be less than about 2 or be less than in about 1.5 minutes and carry.

73. the method for claim 63 or 65, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

74. according to the described method of claim 73, wherein said solubility enhancing agent comprises SBE7-β-CD.

75. according to claim 63,65 or 68 described methods, the budesonide of wherein said moisture suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.

76. according to the described method of claim 75, the budesonide of wherein said moisture suction mixture is with the nominal dosed administration of about 240 μ g/ dosage, about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

77. the method for claim 76, wherein said solubility enhancing agent comprises SBE7-β-CD.

78. the method for claim 76, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:4 with the described ratio that sucks the nominal dosage of suspension.

79. an intake system that is used at patient's treatment that needs are arranged or prevention bronchus constriction obstacle, this system comprises:

(a) comprise the budesonide of nominal dosage and the moisture suction mixture of solubility enhancing agent; With

When giving the budesonide of described patient's name dosage, the PK (pharmacokinetic) profile of sucked suspension of nominal dosage budesonide is compared with comprising of administration under the same conditions, described system provides the enhanced PK (pharmacokinetic) profile that comprises the moisture suction mixture of nominal dosage budesonide of twice at least, substantially go up the pharmaceutically active agents that does not contain except that described corticosteroid with wherein said suction mixture, described suction mixture is gone up the pharmaceutically active agents that does not contain except that budesonide substantially.

80. the intake system of claim 79, the nominal dosage of budesonide is about 0.01:1-1:100 with the described ratio that sucks the nominal dosage of budesonide in the suspension in the wherein said moisture suction mixture.

81. according to claim 79 or 80 described systems, wherein said enhanced PK (pharmacokinetic) profile comprises the C that is equivalent to suck suspension _MaximumThe C of described moisture suction mixture _Maximum, be equivalent to suck the AUC of suspension _{At last}The AUC of described moisture suction mixture _{At last}, be equivalent to suck the AUC of suspension _(0-∞)The AUC of described moisture suction mixture _(0-∞), and/or less than the T of the sucked suspension that comprises budesonide _MaximumThe T of described moisture suction mixture _MaximumAnd wherein said moisture suction mixture is to be lower than the budesonide name dosed administration that can suck suspension.

82. the system of claim 81, the nominal dosage of wherein said moisture suction mixture is about 1:2-1:10 with the described ratio that sucks the nominal dosage of suspension.

83. the system of claim 82, the nominal dosage of wherein said moisture suction mixture is 1:4 with the described ratio that sucks the nominal dosage of suspension.

84. any one system among the claim 79-83, wherein said nebulizer is selected from blast atomizer, ultrasound atomizer, pulsation film nebulizer, comprise the nebulizer or the involving vibrations generator of vibration net with a plurality of holes or plate and contain the nebulizer of hydroecium.

85. the system of claim 79 or 81, wherein said solubility enhancing agent is selected from propylene glycol, non-ionic surface active agent, tyloxapol (tyloxapol), polysorbate80, vitamin E-TPGS, Polyethylene Glycol (macrogol)-15 hydroxy stearic acid ester, phospholipid, lecithin, lecithin purification and/or enrichment, phosphatidylcholine part by the lecithin extraction, dimyristoyl phosphatidyl choline (DMPC), dipalmitoyl phosphatidyl choline (DPPC), distearoyl phosphatidylcholine (DSPC), cyclodextrin and derivant thereof, the SAE-CD derivant, SBE-α-CD, SBE-β-CD, SBE1-β-CD, SBE4-β-CD, SBE7-β-CD, SBE-γ-CD, HP-, 2-HP-β-CD, hydroxyethyl-, hydroxypropyl-gamma-cyclodextrin, ethoxy-gamma-cyclodextrin, dihydroxypropyl-beta-schardinger dextrin-, glucosyl group-alpha-cyclodextrin, the glucose group-beta-cyclodextrin, the glucosulfone group-beta-cyclodextrin, malt-base-alpha-cyclodextrin, malt sugar group-beta-cyclodextrin, malt-base-gamma-cyclodextrin, G 3-, maltotriose glycosyl-gamma-cyclodextrin, two malt sugar group-beta-cyclodextrins, methyl-beta-schardinger dextrin-, the carboxyalkyl sulfide derivative, ORG 26054, ORG 25969, hydroxypropyl emthylcellulose, hydroxypropyl cellulose, polyvinylpyrrolidone, vinyl acetate copolymer, vinyl pyrrolidone, sodium lauryl sulfate, dioctyl sodium sulfosuccinate and combination thereof.

86. 5 described systems according to Claim 8, wherein said solubility enhancing agent comprises SBE7-β-CD.

87. according to claim 79,81 or 84 described systems, the budesonide of wherein said suction mixture is to be less than the nominal dosed administration of about 250 μ g/ dosage.

88. 7 described systems according to Claim 8, the budesonide of wherein said suction mixture is with the nominal dosed administration of about 120 μ g/ dosage, about 60 μ g/ dosage or about 40 μ g/ dosage.

89. the system of claim 87, wherein said solubility enhancing agent comprises SBE7-β-CD.

90. the system of claim 87, the nominal dosage of wherein said moisture suction mixture is 1:2-1:5 with the described ratio that sucks the nominal dosage of suspension.