CN101495385A - Packaging comprising pharmaceutical forms - Google Patents
Packaging comprising pharmaceutical forms Download PDFInfo
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- CN101495385A CN101495385A CNA2007800284707A CN200780028470A CN101495385A CN 101495385 A CN101495385 A CN 101495385A CN A2007800284707 A CNA2007800284707 A CN A2007800284707A CN 200780028470 A CN200780028470 A CN 200780028470A CN 101495385 A CN101495385 A CN 101495385A
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- Prior art keywords
- cap
- bubble
- packing
- container
- film
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
- B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
- B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
- B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D77/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks or bags
- B65D77/04—Articles or materials enclosed in two or more containers disposed one within another
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D83/00—Containers or packages with special means for dispensing contents
- B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills
- B65D83/0445—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments
- B65D83/0463—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, or spherical or like small articles, e.g. tablets or pills all the articles being stored in individual compartments formed in a band or a blisterweb, inserted in a dispensing device or container
Abstract
The invention relates to a packaging comprising solid pharmaceutical forms packed into a container (2) and in blisters (4).
Description
The packing that the present invention relates to comprise container and be packaged in the solid drugs form of medication in the bubble-cap, and relate to by the solid drugs form of medication being packed into bubble-cap and with the bubble-cap method that container comes the stabilization of solid pharmaceutical administration form of packing into.
Bubble-cap hereinafter is meant a kind of packing, and it comprises 2 mutual close adhesion and contains thin plate, film or the paper tinsel that is useful on the cavity that holds packaged solid.Bubble-cap generally includes the sheet plastic or the film (cavity plate or film) of the hot forming that is used for holding solid, after filling that itself and second thin plate, film or paper tinsel (wrapper plate, film or paper tinsel) is closely bonding, i.e. heat-sealing, described second thin plate, film or paper tinsel are made up of aluminium foil and/or sheet plastic or film usually.By pushing cavity plate, film or paper tinsel, packaged solid can be extruded wrapper plate, film or paper tinsel, and individually from bubble-cap, take out.Therefore, bubble-cap also is known as extruded type packing (push-through packs).If since comprise shape, size and/or the intensity of solid and can not " extrude " wrapper plate, film or paper tinsel, also can with sharp objects for example nail scratch wrapper plate, film or paper tinsel and open bubble-cap.Yet, term " bubble-cap " is not limited thereto, also comprise specific embodiment, for example prevent the improved type that children open, for example must carry out the embodiment of 2 different opening operations, it is intended to exceed children's intelligence scope (for example so-called " strip off-extrusion system ") in proper order, perhaps take out be not to scratch but peel off the embodiment of wrapper plate, film or paper tinsel before comprising solid.
Bubble-cap is the preferred primary package method of solid drugs form of medication.Its advantage is the form of medication that can individually take out this form of medication and therefore avoid polluting other, and it is contained in the annular seal space (meaning to have prevented mutual action basically, for example wearing and tearing or adhesion) separated from each other between each form of medication.
The prior function of bubble-cap is for example light, gas, particularly oxygen and the protection against the tide of influence that the pharmaceutical administration form protecting wherein to be comprised is resisted hostile environment.Specifically, above-mentioned function since many medicines to moisture-sensitive and particular importance.Because bubble-cap is contained in the lock carton usually; and carton is not effective barrier of moisture and gas; when the solid drugs form of medication was packaged in bubble-cap (primary package method) and the lock carton (secondary package method), crucial protective effect came from bubble-cap.
Yet being used for the sheet plastic of bubble-cap or film only provides limited protection to resist gas or the moisture that enters from the external world.Various sheet plastics or film are arranged, for example polyvinylchloride (PVC), polyvinylidene chloride (PVDC), high density polyethylene (HDPE) (HDPE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate, it has different material behaviors separately.Although select the material of relative low-moisture permeability, perhaps use composite panel or the complex film made by such as these materials of PVC/PVDC, PVC/HDPE, its randomly also with other poly-mers such as cyclic olefine copolymer (COC) or special many halogenated polymers such as polychlorotrifluoroethylene (PCTFE)
(PVC/PCTFE, PP/COC are (for example
), PVC/COC/PVDC composite panel or complex film) together as barrier layer, entering of moisture reduced to a certain degree, but can not prevent fully that moisture from entering.
Except the selection of plastics, the thickness of material is that the thickness of thin plate, film or paper tinsel also has significant effects to the bubble-cap permeability.Therefore, except selecting material and combination thereof, also can reduce seeing through of gas or moisture by the thickness that increases thin plate, film or paper tinsel to obtain compound plate or film.But,, and can not realize the basic eliminating of desired moisture even these measures also have only limited effect.The difficulty that has also caused higher production complexity, more material to use and thin plate, film or paper tinsel are converted into bubble-cap and its recycle unfriendly.
Also comprise the composite panel of metallic paper or the application of complex film the permeability of moisture or gas is significantly reduced once more, but in this case, in the course of processing (hot forming), produced special difficulty.In case use the composite panel or the complex film that comprise metallic paper, bubble-cap also no longer is transparent, means that the customer can not see wherein contained pharmaceutical administration form, this is undesirable for safety and sale.
Described problem causes many medicines to moisture-sensitive can not be packaged in the bubble-cap that is used for exporting and being sold to the higher area of air humidity, for example torrid areas.
In order to solve described problem, proposed special blister package, thereby it contains desiccant medicine is kept away from moisture.
EP466068 discloses a kind of bubble-cap, and wherein the tablet chamber links to each other with the chamber of containing desiccant in all cases.Yet, each form of medication such as tablet are provided desiccant can be accompanied by a large amount of consumption of material and take up space, this is complicated and expensive for packing technique.
US4753352 discloses a kind of bubble-cap, and wherein a plurality of tablets chamber links to each other with the chamber of containing desiccant.Though it has reduced the packing complexity of each pharmaceutical administration form, only from bubble-cap, take out a pharmaceutical administration form and will open previous bounded system, cause moisture to enter by the opening that produces.After the moisture absorption ability that has exhausted the desiccant that links to each other, the other drug form of medication that links to each other with this desiccant can not be resisted by thin plate or film subsequently fully and be connected the moisture that the passage of desiccant enters.And, in any system, all can not get rid of taking-up and edible desiccant but not the situation of pharmaceutical administration form, this is extremely serious for security reason.
About the above-mentioned problem of eating unintentionally, EP779872A1 propose to strengthen the bubble-cap of desiccant cavity region, and it is used to prevent that desiccant from being eaten unintentionally by the user.But this causes the additive incrementation of production complexity and cost, in any case, all can increase complexity and cost owing to introduce desiccant.
In view of simple bubble-cap only provides inadequate moisture protection usually, the bubble-cap that contains desiccant has complicated structure, be difficult to make and the cost height, can not with the production facilities manufacturing of simple bubble-cap, since contain desiccant take more space and therefore increase to the demand of storage space and/or be subjected to the influence of safety issue.And, adopt the bubble-cap that contains desiccant can not guarantee sufficient moisture protection all the time equally.
The simple packing that the purpose of this invention is to provide pharmaceutical administration form, wherein there is the influence that it has guaranteed the failure-free moisture protection and has not been subjected to the problems referred to above in this pharmaceutical administration form with the form of separating.
Be surprisingly, reached this purpose by the following method: at first pharmaceutical administration form is put into simple bubble-cap, subsequently the latter is put into container, container inner wall at least on the subregion embedding at least a passage carrier (channel former) and at least a absorbent, and with seal of vessel.Therefore the present invention relates to comprise that reclosable container and at least one contain the packing of the bubble-cap of one or more solid drugs form of medication, the inwall of described container on subregion at least embedding at least a passage carrier and at least a absorbent, wherein said blister pack is contained among the container.
Described container is used to store at least one bubble-cap.Therefore, it can have any spatial form that can realize this function, that is, those are fit to hold the shape of at least one bubble-cap.The preferred vessel space shape that matches with the bubble-cap size.For example, if want to store the bubble-cap of rectangle, the container that preferably has identical basic configuration promptly has the cubic space shapes of containers, if want to store circular bubble-cap, preferably has the cylindrical space shapes of containers.Yet, no matter the shape of bubble-cap is how, equally may any required spatial form used according to the invention as container, as long as it is suitable for holding this bubble-cap.For example, circular-cap also can be stored in to have in the cubic space shapes of containers, and perhaps rectangular blister also can be stored in and have in the cylindrical space shapes of containers.
Indivedual embodiment of the present invention is described with figure.Come the assembly of embodiment shown in the presentation graphs with unified numbering, promptly the same numbering among the figure is all represented identical assembly in all cases.
Fig. 1 has shown the cube container that contains rectangular blister.Container comprises wall (2), and its inside face is comprising at least a passage carrier and at least a absorbent on the subregion at least, has the lid (1) that is used to close and (choosing wantonly) auxiliary opening means (3) is provided.Bubble-cap (4) contains the chamber (5) that is useful on the holding solid pharmaceutical administration form.
Similar to Fig. 1, Fig. 2 has shown cube container and bubble-cap, but this container and circular-cap are of different sizes.
Fig. 3 has shown to have the cylindrical space shapes of containers.Circular wall (2) comprises at least a passage carrier and at least a absorbent on the subregion at least of inside face, and is furnished with suitable dome (1) and (choosing wantonly) filling auxiliary device (3).Bubble-cap (4) has stripe design, contains the oval chamber (5) that is useful on the holding solid form of medication, and is furnished with the auxiliary device (6) that is used to tear, and bubble-cap can be separated along it.
Container is reclosable.Resealable is meant that container can open repeatedly and cut out again, promptly at least once, preferred repeatedly, preferred especially at least be contained in bubble-cap in the quantity that is used to be contained in the solid drugs form of medication among the container corresponding.Open at every turn with sealing operation after with seal of vessel enter internal tank so that prevent moisture and gas effectively.
By realizing opening and sealing of container with the fully enclosed closing device of container coupling.Be not limited to a closing device.It can use all types of closing devices, even as long as can guarantee that after switch container repeatedly gas and/or moisture can not enter the internal tank under the air-tight state.Container can have one or more closing devices.In the situation of cube container, each square surface all can be designed to closing device basically.Fig. 4 has shown the embodiment of the cube container with 2 closing devices.
According to embodiment of the present invention, lid (1) is as closing device.The example of lid is such as the spiral closing device, and lid folds into the upper limb of container or stretches into internal tank.Under the situation of the spatial form that corner angle are arranged, for example cube in order to increase the leak tightness of container opposing gas and moisture, also can become the corner angle of opening and associated lid round a little.
According to embodiment preferred, container has the cubic space shape, becomes the corner angle (7) of circle and can pile up (see figure 5) well.
The absorbent and the passage carrier that are included in the container can directly be present in the container inner wall that is formed by poly-mer jointly, perhaps as the one deck on the inwall of polymer container.Absorbent and passage carrier can also be embedded among the liner as the container embedded body so that container to the small part inwall with it as liner.
Inwall is meant the inside face of wall of container, promptly with the vessel surface that the solid drugs form of medication in the bubble-cap contacts that is packaged in that is wherein held.
The suitable material that is used for container is a poly-mer.Specifically, can thermoplastic plastic be arranged as poly-mer with the compound of absorbent and passage carrier, for example polyolefin, for example polyethylene and/or polypropylene, polyisoprene, poly-butadiene, polybutene, polysiloxane, polyamide, ethylene-vinyl acetate copolymer, ethene-methacrylic acid copolymer, polystyrene, polyester, polyanhydride, the polyacrylates nitrile, polysulfonates, polyester-amides, polyacrylates, propylene-maleic anhydride, polyvinyl-maleic anhydride, polyethylene-urethanes, polyethylene-ethyl vinyl alcohol, polyethylene-nylon and/or polyurethane.By the total weight of the compound of poly-mer, passage carrier and absorbent, the wall of absorbent that provides on the surface and passage carrier is the 10-90 weight % of polymer content within it.
The absorbent that can exist is the desiccant of any kind basically, promptly in conjunction with the cementitious agent of moisture.Consider three groups of desiccant:
First group comprises the chemical substance that forms hydrate with water.The example of this class chemical substance is anh salt, and it tends to absorb water or the moisture absorption and the stable hydrate of formation in this process.Moisture is combined and prevent its release by chemical reaction.
Second group of desiccant contains the material of reactivity.Described material and water or moisture reaction generate new material.Newly-generated material is normally stable at low temperatures, and it only is only reversible under the situation of high energy consumption.This class desiccant be mainly used in dry solvent and when poly-mer itself need to keep more low-moisture state as absorbent material.
The 3rd group of desiccant by physical adsorption in conjunction with moisture.This desiccant comprises to have moisture is sucked particle in the capillary tub.Aperture capillaceous and its density have determined absorbent properties in the desiccant.The example of this class desiccant is molecular sieve, silica gel, some synthetic polymer (for example those are used for nappy poly-mer) and starch.The 3rd group of desiccant preferably is contained in the container because its be basically inertia with water-insoluble.Especially preferably have herein the 3-15 dust the aperture molecular sieve and/or have the silica gel in the aperture of 24 dusts.
The passage carrier that can consider is a hydroaropic substance, for example polyethylene glycols, ethyl vinyl alcohol, glycerine, polyvinyl alcohol, polyvinylpyrrolidone, vinyl pyrrolidone, N-methyl pyrrolidone, polysaccharide, carbohydrate and/or sugar alcohol.Preferred polyethylene glycols is carbowax and/or polypropylene glycol.Operable sugar for example is glucose, mannose, galactose and/or fructose.Suitable sugar alcohol for example is sweet mellow wine, sorbierite, hexitol, dulcitol, xylitol, ribitol and/or erythrite.Polysaccharide is meant for example dextrin and/or hydrolyzed starch.
In the inwall that provides absorbent and passage carrier, by the total weight of the compound of poly-mer, passage carrier and absorbent, the part by weight of passage carrier can be 10-40%.
Absorbent and passage carrier are embedded in the inwall of container, its zone, cover part or Zone Full.The zone, cover part is meant that at least a portion comprises absorbent and passage carrier in the Zone Full that forms container inner wall.Cover Zone Full and be meant that the Zone Full that forms container inner wall all comprises absorbent and passage carrier.According to advantageous embodiment, by whole inner surface areas of container, absorbent and passage carrier are present at least 10%, preferably at least 50%, especially preferably at least 90% of inwall.
The container of being made, comprising absorbent and passage carrier and be suitable as packing of the present invention by poly-mer is known in the prior art, and for example is described among WO 97/32663A1, the EP1000873A2 and WO 03/086900A1, EP 1421991A1.The container that can be used for the present invention's packing is commercial buying, for example by Capitol Specialty Plastics company, 2039McMillan Street Aubum, the Alabama, the U.S. provides, trade mark is called Activ-Vial, perhaps by Sud Chemie, Ostenrieder Str.15,85368 Moosburg, Germany provides, and trade mark is called 2AP Multipolymer.
Described bubble-cap can preferably and valuably be made by simple sheet plastic or film with aqueous vapor high-permeability.Bubble-cap is put into container and with its sealing after, container with being placed among the dry environment, is guaranteed dry environment by the drying effect of the absorbent in wall of container.Relative when higher when compare bubble-cap inside (containing the solid drugs form of medication) humidity with internal tank (guaranteeing drying) by desiccant, moisture arrives internal tank by the sheet plastic or the film diffusion of bubble-cap, and it is present in the desiccant absorption in the wall of container there.If when the pharmaceutical administration form in bubble-cap had than the higher aqueous ingredients in the bubble-cap inside that surrounds them, moisture was diffused into bubble-cap inside by pharmaceutical administration form, further sheet plastic or the film by bubble-cap as described enters internal tank then.This solid drugs form of medication even can obtain drying thus after with its packing is arranged under the situation of high-moisture more comparing pharmaceutical administration form with internal tank.
Compare with the commercial bubble-cap of buying that is packaged in the lock carton, at the secondary package of conventional bubble-cap for example in the lock carton, the moisture diffusion of ecto-entad takes place usually, promptly towards the direction of pharmaceutical administration form, and the reverse of moisture diffusion direction has taken place in packing of the present invention, direction from inside to outside appears, the moisture diffusion of promptly leaving blister and leaving pharmaceutical administration form.Therefore, pharmaceutical administration form is owing to packing of the present invention obtains drying, even also be that so this has advantageously caused the further increase of shelf life, particularly when pharmaceutical administration form has the sensivity composition after the pharmaceutical administration form in the bubble-cap is prepared and packs.
After being divided in pharmaceutical administration form in the bubble-cap, the dry run owing to occurring in the packing of the present invention also can provide described pharmaceutical administration form with lower cost, because can save or reduce required dry number of times after its preparation.
Being suitable for preparing the bubble-cap that is fit to the present invention's packing and being all can be in corresponding workshop, particularly change bubble-cap in the hot forming workshop into and have all sheet plastics or the film of certain aqueous vapor permeability.The example that is suitable for preparing the sheet plastic of bubble-cap or film has polyvinylchloride (PVC), polyvinylidene chloride (PVDC), high density polyethylene (HDPE) (HDPE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate, cyclic olefine copolymer (COC), special many halogenated polymers, as polychlorotrifluoroethylene (PCTFE)
And composite panel or the complex film made by these materials, for example PVC/PVDC, PVC/HDPE, PVC/PCTFE, PP/COC
PVC/COC/PVDC, the particularly suitable PVC of being, PVDC, HDPE, PP, PET and by its composite panel of making or complex film, fit closely is PVC, PP and PET.Described sheet plastic or film can be used as cavity plate or film and/or are used as wrapper plate or film.Cavity plate or film preferably include sheet plastic or film at least.
The sheet plastic of low thickness or film are preferably and be advantageously used in the preparation bubble-cap.This is because the material thickness of thin plate or film reduces the reduction that also is accompanied by its diffusional resistance, so that described pharmaceutical administration form is owing to removing moisture at lay up period and can stablizing quickly.Be used as the cavity plate or the sheet plastic of film or the thickness of film and be generally 10-500 μ m, preferred 15-300 μ m, preferred especially 15-100 μ m, very preferably 15-50 μ m.
To the low thickness of the high-permeability of aqueous vapor and thin plate or film make adopt cheap sheet plastic or film for example PVC, PP and PET become possibility, its aqueous vapor permeability (WVP) is respectively about 3.5,0.84 and 5.4g/cm according to DIN53122 under the thickness of 250 μ m
224h.Except the economical with materials cost, also can with this class thin plate or film be processed and be supplied to conventional hot forming workshop well, obtain extra cost advantage.
Aluminium foil with low permeability is generally used for sealed blister.In packing of the present invention, low permeability is optional, means also to use other materials to come sealed blister.This makes it possible to sheet plastic or film as wrapper plate or film, also can use and cavity plate or film identical materials thin plate or the film made.The packing advantageous particularly of such homogenous material, because needn't be in advance cavity plate or film and wrapper plate or membrance separation just can be reclaimed it, this is special needs with regard to the reason of environmental protection.If sheet plastic or film are used as wrapper plate or film, the aqueous vapor that exists in the blister also can be removed by wrapper plate or film, and this has advantageously increased the rate of drying that is included in the pharmaceutical administration form in the bubble-cap.In addition, if use the sheet plastic or the film of ultralow material thickness, except reducing material usage, rate of drying further increases, and the taking-up that is included in the solid drugs form of medication in the bubble-cap will be more prone to, because can more easily it be extruded.
According to advantageous embodiment, at least one hole is contained in each chamber that comprises the bubble-cap of solid drugs form of medication.The hole preferably has＜diameter of 1mm, and they have been simplified from gas and exchange of moisture in the blister of the internal tank of the present invention's packing, this means the remarkable increase of rate of drying.The hole also makes the sheet plastic or the film that have gas and moisture high-permeability and thicken can be used to bubble-cap, simultaneously can because of drying reduce influence stable.Therefore the present invention also relates to according to packing of the present invention, the bubble-cap that it is characterized in that being included in this packing all has at least one hole in containing each chamber of solid drugs form of medication.
If there are a plurality of holes, it is preferably the little otch/punching of a row, the form of promptly poroid seam (perforation), and it has particularly simplified the operation of tearing along formed line.Therefore the present invention also relates to it is characterized in that exist in each chamber the packing of a plurality of holes as poroid seam.
Particularly preferred poroid seam is a miniature poroid seam (microperforation), and promptly the diameter separately in hole is 0.25-0.05mm, and it can be in thin plate or film middle punch.Therefore the invention still further relates to the poroid seam that it is characterized in that in each chamber is the packing of miniature poroid seam.
Described hole/poroid seam may reside among the cavity plate or film and/or wrapper plate or film of bubble-cap, and is introduced into thin plate or film before or after filling bubble-cap.Can introduce hole/poroid seam with method well known in the prior art, for example adopt mechanical punching or iron hole (burning-in) by laser.Can before sheet plastic or film change bubble-cap into, between its tour and after preparation and filling bubble-cap, described hole/poroid seam be introduced sheet plastic or film.
If use the thin plate or the film of pre-punching/pre-punching, preferably only wrapper plate or film punched/bore a hole.This makes it possible in the hot forming workshop of routine cavity plate or film be carried out the processing (problem-free processing) of no problem, and prevents to be polluted pharmaceutical administration form is introduced into cavity in the hot forming workshop after.Can without a doubt the cavity plate or the film of filling be heat sealed to wrapper plate or film subsequently, preferably the latter be bored a hole, especially preferably to its micropunch.Fig. 3 has shown the bubble-cap (4) that provides poroid seam (8).If when taking out pharmaceutical administration form by extruding wrapper plate or film, then preferably introduce poroid seam in the following manner, that is, under the situation of pushing cavity plate or film, can tear wrapper plate or film, and can take out described form of medication in simple mode along poroid seam.Therefore, the invention still further relates to packing of the present invention, it is characterized in that hole, poroid seam or miniature poroid seam are introduced wrapper plate or film in all cases.
Can be included in pharmaceutical administration form in the described packing and be all at room temperature for the solid-state physics state and be used for for example oral, anus or the solid drugs form of medication of vagina administration.This comprises all solids pharmaceutical administration form that is used for taking out from container the direct administration in back, for example tablet, dragee, hard shell capsules, granule, pilule, powder, suppository, and comprise that also but those need be translated into the pharmaceutical administration form of form of medication before administration, for example dried juice for example needs to be translated into the powder type of solution before administration.Described pharmaceutical administration form is tablet, dragee, hard shell capsules, particulate matter, suppository, pilule or powder preferably.Hard shell capsules has the shell that does not add plasticizer, it can be divided into the upper and lower, and is made up of for example gelatin or starch.
The invention still further relates to the method for the described packing of preparation, it is characterized in that with the solid drugs form of medication pack into bubble-cap and the sealing, but subsequently the leak free bubble-cap is introduced in the container of forming by the container of deadend, this container inner wall at least in the subregion embedding at least a passage carrier and at least a absorbent.
Contextual pharmaceutical administration form is meant the term that becomes known for to the various technical form of medication of human or animal's drug administration.Therefore, " pharmaceutical administration form " this term and concrete law situation are irrelevant and be not limited to medicine in any form, and multiple material is arranged, and for example medicine, dietary supplement ingredient and/or functional components can be as components.The example that is used for the pharmaceutical administration form of the object of the invention can be the form of medicine and dietary supplement ingredient.
Surprisingly, method of the present invention also makes vendible product of supply solid drugs form of medication become possibility, so and according to this series products of prior art in the past since its do not have also to be not suitable for so far enough storage periods to sell.After changing described form of medication over to container, moisture is removed continuously and for a long time from form of medication by the absorbent in the container inner wall.The removing of moisture occurs in the very big zone and under the gentle condition, causes the solid drugs form of medication stable at its lay up period thus.
Therefore, the present invention also relates to increase the method for the shelf life of solid drugs form of medication, it is characterized in that with the solid drugs form of medication pack into bubble-cap and the sealing, but subsequently the leak free bubble-cap is introduced in the container of forming by the container of deadend, this container inner wall at least in the subregion embedding at least a passage carrier and at least a absorbent.
The stabilization of packing of the present invention is based on the influence of container to contained solid drugs form of medication in the bubble-cap, thereby it can be provided in the mode that can stablize storage.Therefore, realize that the solid drugs form of medication that effect of the present invention needs will be contained in the bubble-cap is contained in the container, that is, pharmaceutical administration form, bubble-cap and container are jointly in this packaged form.
Packing of the present invention all has stabilization for wherein reactive compound and/or auxiliary material to all solids pharmaceutical administration form of moisture-sensitive.Example to the reactive compound of moisture-sensitive has many pharmaceutical active compounds, for example hormone or protein, vitamin, cell, for example probiotic bacterial cultures.
Packing of the present invention preferably comprises this class solid drugs form of medication, and it contains to the reactive compound of moisture-sensitive and/or to the combination of the auxiliary material or the auxiliary material of moisture-sensitive.Auxiliary material to moisture-sensitive for example is combined as, and the combination of organic acid such as citric acid and carbonate such as sodium bicarbonate or saleratus is as used in effervescent tablet.
In addition, the solid drugs form of medication in the packing of the present invention according to embodiment, can comprise conventional auxiliary material and additive.Auxiliary material and/or additive-treated oil select also to depend on the food articles of law of country for contained solid drugs form of medication in the packing that is intended to use.The auxiliary material and/or the additive that use in for example tablet, multilayer tablet, dragee, hard shell capsules, granule, pellets preparation and/or powder have: starch (for example cornstarch), french talc, microcrystalline cellulose, lactose, high dispersive silicon dioxide, polyvinylpyrrolidone and/or cellulose powder.Other components that can be used as the existence of adhesives and/or releasing agent have: carbohydrate, for example sweet mellow wine, sorbierite, xylitol, glucose, sucrose, fructose, maltose, dextrose, maltodextrin and/or kaolin, and/or cellulose derivative, as methylcellulose, hydroxypropyl cellulose and/or HPMC, and/or calcium carbonate, calcium stearate, dolomol and/or tristerin.In addition, the solid drugs form of medication in packing also can contain dyestuff, flavoring additives and/or aromatic, and lubricant, antioxidant and/or stabilizer.The content of these base substances depends on the content of the material used such as medicine, dietary supplement ingredient, functional components on the one hand, the standard that depends on the mechanical-physical character of decision oral administration form on the other hand is as hardness, compressibility, size, color and/or shape.
Solid drugs form of medication in packing also can be prepared by the whole bag of tricks well known by persons skilled in the art.These methods are recorded in for example H.Sucker, P.Fuchs, P.Speiser, " Pharmazeutische Technologie " [Pharmaceutical Technology], Stuttgart1978, or K.H.Bauer, K.H.Fromming, C.Fuhrer, " PharmazeuischeTechnologie " [Pharmaceutical Technology] is among the Stuttgart 1986.They are incorporated herein by reference, and thus as the part of disclosure.
Embodiment is used for explaining the present invention, but scope of the present invention is not limited.
Embodiment 1:
With the described 3 synusia agent that similarly contain probiotic bacteria of EP 931543A1
Preparation:
The bacteria preparation that accounts for weight 3% (is contained Jia Shi lactobacillus (Lactobacillus gasseri), bifidobacterium bifidum (Bifidobacterium bifidum), bifidobacterium longum (Bifidobacteriumlongum)), account for the synanthrin of 10.5% weight, account for the calcium phosphate of 8.6% weight, account for the cellulose of 5.7% weight, account for the auxiliary material ((disintegrant of 2.3% weight, releasing agent) (ground floor), (mineral matter, micro-element, dyestuff, disintegrant, releasing agent, cellulose) (second layer) and (vitamin, micro-element, disintegrant, releasing agent and cellulose) (the 3rd layer)) compound compacting continuously in of (percentum data in all cases by total sheet restatement) from the 3 synusia agent bead machines (rotary) of E.Hata, obtain being of a size of 3 synusia agent of the rectangle of 18mm * 8mm.Tablet for gained provides film coating (coming the aqueous system of self-contained HPMC, hydroxypropyl cellulose and releasing agent) subsequently, and the amount of dressing accounts for 5% of label weight, corresponding to 11mg/cm
2Tablet surface.Obtaining every weight is 3 synusia agent of the dressing of 1050mg.
Store and check:
The stability of check film tablet in stability study., the film tablet is packed in the PVC/ aluminium bubble-cap (packing method A) for this reason, or the PVC/ aluminium bubble-cap and the latter introduced in the packing that its inwall is embedded with passage carrier and absorbent (packing method B) of packing into, and be stored under the 40 ℃/75%RH.Through behind the preset time, tablet is taken out from the cache, measure the microbe quantity that exists under each situation with the conspicuous pour plate method of section by counting.The results are shown in (3 batches aviation values) in the table 1.
Table 1
Embodiment 2:
Preparation:
In bead machine, be pressed into circular piece with accounting for the nicorandil of 10% weight and the compound of auxiliary material (extending agent, disintegrant and releasing agent).Obtain the tablet that every weight is 100mg.
Claims (13)
1. packing, it comprises that reclosable container and at least one contain the bubble-cap of one or more solid drugs form of medication, the inwall of described container on subregion at least embedding at least a passage carrier and at least a absorbent, wherein said blister pack is contained among the container.
2. according to the packing of claim 1, it is characterized in that container has cubical basic configuration.
3. according to the packing of claim 1 or 2, it is characterized in that container contain as absorbent, by the desiccant of physical adsorption in conjunction with moisture.
4. according to the packing of claim 3, it is characterized in that described desiccant is molecular sieve or silica gel.
5. according to the packing of claim 1, the cavity plate of the bubble-cap that it is characterized in that wherein being comprised or film and/or wrapper plate or film are made up of polyvinylchloride (PVC), polyvinylidene chloride (PVDC), high density polyethylene (HDPE) (HDPE), polypropylene (PP), polyethylene terephthalate (PET), polycarbonate, cyclic olefine copolymer (COC), polychlorotrifluoroethylene (PCTFE), or form for example PVC/PVDC, PVC/HDPE, PVC/PCTFE, PP/COC, PVC/COC/PVDC by composite panel or complex film that these materials are made.
6. according to the packing of claim 5, it is characterized in that cavity plate or film and/or wrapper plate or film be made up of PVC, PP or PET.
7. according to the packing of claim 1, the bubble-cap that it is characterized in that being included in this packing all has at least one hole in containing each chamber of solid drugs form of medication.
8. according to the packing of claim 7, it is characterized in that existing in each chamber a plurality of holes as poroid seam.
9. packing according to Claim 8 is characterized in that described poroid seam is miniature poroid seam.
10. according to one or multinomial described packing among the claim 7-9, it is characterized in that hole, poroid seam or miniature poroid seam are introduced wrapper plate or film in all cases.
11. according to the packing of claim 1, the solid drugs form of medication in the bubble-cap that it is characterized in that wherein being comprised is tablet, dragee, capsule, granule, suppository, pilule and/or powder.
12. preparation is according to the method for or multinomial described packing among the claim 1-11, it is characterized in that with the solid drugs form of medication pack into bubble-cap and the sealing, but subsequently the leak free bubble-cap is introduced in the container of forming by the container of deadend, this container inner wall at least in the subregion embedding at least a passage carrier and at least a absorbent.
13. increase the method for the shelf life of solid drugs form of medication, it is characterized in that with the solid drugs form of medication pack into bubble-cap and the sealing, but subsequently the leak free bubble-cap is introduced in the container of forming by the container of deadend, this container inner wall at least in the subregion embedding at least a passage carrier and at least a absorbent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06016222.9 | 2006-08-03 | ||
| EP06016222 | 2006-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101495385A true CN101495385A (en) | 2009-07-29 |
Family
ID=38537812
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007800284707A Pending CN101495385A (en) | 2006-08-03 | 2007-07-04 | Packaging comprising pharmaceutical forms |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20090314664A1 (en) |
| EP (1) | EP2046662A1 (en) |
| JP (1) | JP2009545343A (en) |
| KR (1) | KR20090036606A (en) |
| CN (1) | CN101495385A (en) |
| AU (1) | AU2007280754B2 (en) |
| BR (1) | BRPI0714619A2 (en) |
| CA (1) | CA2659558A1 (en) |
| MX (1) | MX2009001041A (en) |
| RU (1) | RU2448026C2 (en) |
| WO (1) | WO2008014862A1 (en) |
| ZA (1) | ZA200901464B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101865595A (en) * | 2009-04-14 | 2010-10-20 | 瑞阳制药有限公司 | New application of molecular sieve and drying method of solid drugs |
| RU198835U1 (en) * | 2019-12-30 | 2020-07-29 | Общество с ограниченной ответственностью "Научно-производственная фирма "ЛАБОВЭЙ" | Blister packaging for glucose oxidase membranes |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2109570A1 (en) * | 2007-01-20 | 2009-10-21 | Merck Patent GmbH | Packaging containing soft capsules |
| ES2396735T3 (en) * | 2008-03-05 | 2013-02-25 | Rivopharm Sa | Vehicles for the Nicorandil with improved stability |
| MX2010010275A (en) * | 2008-03-17 | 2010-09-30 | Procter & Gamble | User-customizable dosing system. |
| WO2009147095A1 (en) * | 2008-06-04 | 2009-12-10 | Boerhringer Ingelheim International Gmbh | Method of drying sheets |
| DE102008056123B4 (en) * | 2008-11-06 | 2017-11-16 | Klöckner Pentaplast Gmbh | Multilayer film and blister packaging |
| EP2400950B1 (en) | 2009-02-26 | 2019-05-22 | Glaxo Group Limited | Pharmaceutical formulations comprising 4-{(1 r)-2-[(6-{2-[(2,6-dichlorobenzyl)oxy]ethoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol |
| WO2010101115A1 (en) * | 2009-03-02 | 2010-09-10 | アステラス製薬株式会社 | Package of solid pharmaceutical preparation |
| AU2010301098A1 (en) * | 2009-10-01 | 2012-05-17 | Richard W. Bland | Coal fine drying method and system |
| GB0921075D0 (en) | 2009-12-01 | 2010-01-13 | Glaxo Group Ltd | Novel combination of the therapeutic agents |
| US8479921B2 (en) | 2009-12-09 | 2013-07-09 | Amcor Flexibles, Inc. | Child resistant blister package |
| JP5866304B2 (en) | 2010-03-18 | 2016-02-17 | メドコーム ホールディング エーピーエス | Opening system for medical blister package |
| US20110266189A1 (en) * | 2010-05-03 | 2011-11-03 | Tom Nicole L | Blister packaging |
| US9592179B2 (en) | 2011-09-21 | 2017-03-14 | Medcomb Holding Aps | Disposable rigid container for pharmaceutical compositions |
| US20140264167A1 (en) * | 2013-03-15 | 2014-09-18 | Multisorb Technologies, Inc. | Water vapor barrier composition |
| DE14721256T1 (en) * | 2013-04-22 | 2017-03-16 | Sandoz Ag | PHARMACEUTICAL COMPOSITIONS WITH CRYSTALLINE MACITENTANE |
| CA2986107A1 (en) * | 2015-05-25 | 2016-12-01 | Wewewe Gmbh | Insertion body, assembly of insertion bodies and method for inserting an insertion body |
| JP6927663B2 (en) * | 2015-10-23 | 2021-09-01 | ニプロ株式会社 | Solid preparation package and odor removal method for solid preparation |
| KR102503428B1 (en) * | 2015-12-22 | 2023-02-24 | 한미약품 주식회사 | Package for oral soft capsule formulation comprising dutasteride |
| EP3568294A4 (en) * | 2017-01-16 | 2020-09-16 | Multisorb Technologies, Inc. | Thermoformable multilayer moisture barrier and method of making the same |
| US11208247B2 (en) | 2017-07-31 | 2021-12-28 | Société des Produits Nestlé S.A. | Packaging for solid dosage forms of melatonin with a high citric acid concentration |
| US20190314318A1 (en) * | 2018-04-11 | 2019-10-17 | Robert Benson Aylor | Suppression and prevention of tumors and treatment of viruses |
| DE102018112817A1 (en) | 2018-05-29 | 2019-12-05 | Klöckner Pentaplast Gmbh | Transparent polymer film with discoloration compensation |
| IT202000000787A1 (en) * | 2020-01-17 | 2021-07-17 | Sacmi Imola Sc | PROCEDURE FOR THE PRODUCTION AND FILLING OF CONTAINERS INTENDED TO CONTAIN FOOD. |
| JP2023551656A (en) | 2020-11-18 | 2023-12-12 | クロックナー、ペンタプラスト、オブ、アメリカ、インコーポレイテッド | Thermoformed packaging and its forming method |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3403776A (en) * | 1967-03-21 | 1968-10-01 | Johnson & Johnson | Sterile surgical package |
| US3567085A (en) * | 1968-12-02 | 1971-03-02 | James G Flores | Neck-supported pill container |
| US3545604A (en) * | 1969-01-23 | 1970-12-08 | Conn Med Corp | Package |
| US3913734A (en) * | 1972-08-03 | 1975-10-21 | Pharmacare Inc | Package assembly |
| US3851571A (en) * | 1972-08-28 | 1974-12-03 | Nichols Prod Inc | Apparatus and method for encapsulating eggs |
| FR2593152B1 (en) * | 1986-01-22 | 1988-12-23 | Adir | WATERPROOF PACKAGING IN THE FORM OF ALVEOLAR PLATES ALLOWING FOR GAS EXCHANGES BETWEEN THE ALVEOLES. |
| US4923702A (en) * | 1987-07-20 | 1990-05-08 | Powell Levisky | Communion container |
| DE9013901U1 (en) * | 1990-10-05 | 1990-12-20 | Hoechst Ag, 6230 Frankfurt, De | |
| US5171593A (en) * | 1991-10-15 | 1992-12-15 | Eastern Shore Printing Corporation | Ventilated produce package, and method of making the same |
| US5346069A (en) * | 1992-09-24 | 1994-09-13 | Intini Thomas D | Container |
| US5610170A (en) * | 1993-01-22 | 1997-03-11 | Otsuka Pharmaceutical Factory, Inc. | Package form for bicarbonate-containing powdery pharmaceutical compositions and a method of stabilizing the compositions |
| JP3409543B2 (en) * | 1994-12-26 | 2003-05-26 | 味の素株式会社 | Anti-caking packaging container |
| US5740938A (en) * | 1995-03-14 | 1998-04-21 | Magenta Corporation | Safety container |
| US6221446B1 (en) * | 1995-04-19 | 2001-04-24 | Capitol Specialty Plastics, Inc | Modified polymers having controlled transmission rates |
| US6124006A (en) * | 1995-04-19 | 2000-09-26 | Capitol Specialty Plastics, Inc. | Modified polymers having controlled transmission rates |
| EP1000873B1 (en) * | 1995-04-19 | 2003-11-19 | CSP Technologies, Inc. | Desiccant material included in a closed container |
| US6080350A (en) * | 1995-04-19 | 2000-06-27 | Capitol Specialty Plastics, Inc. | Dessicant entrained polymer |
| US5911937A (en) * | 1995-04-19 | 1999-06-15 | Capitol Specialty Plastics, Inc. | Desiccant entrained polymer |
| GB9525065D0 (en) * | 1995-12-07 | 1996-02-07 | Smithkline Beecham Plc | Packaging system |
| US6173838B1 (en) * | 2000-01-31 | 2001-01-16 | Owens Illinois Closure Inc. | Child-resistant medication compact |
| US6652144B2 (en) * | 2002-02-19 | 2003-11-25 | Super Chill Beverage Group Inc. | Beverage container pouch |
| US7413083B2 (en) * | 2002-04-11 | 2008-08-19 | Csp Technologies, Inc. | Desiccant vial assembly for effervescent tablets |
| US20030203141A1 (en) * | 2002-04-25 | 2003-10-30 | Blum John B. | Blister package |
| US8110260B2 (en) * | 2007-02-02 | 2012-02-07 | Rick Merical | Containers intended for moisture-sensitive products |
| US7051876B2 (en) * | 2002-08-29 | 2006-05-30 | Colbert Packaging Corporation | Pilfer-resistant packaging with criss-cross grain pattern |
| GB0223798D0 (en) * | 2002-10-12 | 2002-11-20 | Cambridge Consultants | Apparatus for releasing tablets from a blister pack |
| FR2848535B1 (en) * | 2002-12-17 | 2005-07-15 | D Lab | SINGLE USE PACKAGING FOR LIQUID, PASTY OR PULVERULENT PRODUCT |
| RU2238894C1 (en) * | 2003-01-13 | 2004-10-27 | Плетнев Владимир Адольфович | Package |
| US20070163917A1 (en) * | 2004-07-16 | 2007-07-19 | Pfizer Inc. | Package and device for simultaneously maintaining low moisture and low oxygen levels |
| US20060042990A1 (en) * | 2004-08-24 | 2006-03-02 | Galuten Jerry H | Medication kit |
| US20060065670A1 (en) * | 2004-09-21 | 2006-03-30 | Arjowiggins Security | Packaging device for dispensing security-protected units of product |
| EP1733872A1 (en) * | 2005-06-15 | 2006-12-20 | Alcan Technology & Management Ltd. | Cold formable laminate |
| US20110240511A1 (en) * | 2008-12-10 | 2011-10-06 | Merck Sharp & Dohme Corp. | Packaging for oxygen-sensitive pharmaceutical products |
-
2007
- 2007-07-04 MX MX2009001041A patent/MX2009001041A/en active IP Right Grant
- 2007-07-04 CN CNA2007800284707A patent/CN101495385A/en active Pending
- 2007-07-04 AU AU2007280754A patent/AU2007280754B2/en not_active Ceased
- 2007-07-04 KR KR20097004477A patent/KR20090036606A/en not_active Application Discontinuation
- 2007-07-04 EP EP07765037A patent/EP2046662A1/en not_active Withdrawn
- 2007-07-04 CA CA 2659558 patent/CA2659558A1/en not_active Abandoned
- 2007-07-04 RU RU2009107273/12A patent/RU2448026C2/en not_active IP Right Cessation
- 2007-07-04 WO PCT/EP2007/005898 patent/WO2008014862A1/en active Application Filing
- 2007-07-04 JP JP2009522123A patent/JP2009545343A/en active Pending
- 2007-07-04 US US12/375,556 patent/US20090314664A1/en not_active Abandoned
- 2007-07-04 BR BRPI0714619-1A patent/BRPI0714619A2/en not_active IP Right Cessation
-
2009
- 2009-03-02 ZA ZA200901464A patent/ZA200901464B/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101865595A (en) * | 2009-04-14 | 2010-10-20 | 瑞阳制药有限公司 | New application of molecular sieve and drying method of solid drugs |
| RU198835U1 (en) * | 2019-12-30 | 2020-07-29 | Общество с ограниченной ответственностью "Научно-производственная фирма "ЛАБОВЭЙ" | Blister packaging for glucose oxidase membranes |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0714619A2 (en) | 2013-04-30 |
| ZA200901464B (en) | 2010-03-31 |
| RU2009107273A (en) | 2010-09-10 |
| JP2009545343A (en) | 2009-12-24 |
| KR20090036606A (en) | 2009-04-14 |
| EP2046662A1 (en) | 2009-04-15 |
| AU2007280754A1 (en) | 2008-02-07 |
| CA2659558A1 (en) | 2008-02-07 |
| AU2007280754B2 (en) | 2013-02-28 |
| US20090314664A1 (en) | 2009-12-24 |
| WO2008014862A1 (en) | 2008-02-07 |
| RU2448026C2 (en) | 2012-04-20 |
| MX2009001041A (en) | 2009-02-06 |
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Open date: 20090729 |