CN101450140A - Preparation method of schizonepetae and forsythia decoction - Google Patents
Preparation method of schizonepetae and forsythia decoction Download PDFInfo
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- CN101450140A CN101450140A CNA2007101958272A CN200710195827A CN101450140A CN 101450140 A CN101450140 A CN 101450140A CN A2007101958272 A CNA2007101958272 A CN A2007101958272A CN 200710195827 A CN200710195827 A CN 200710195827A CN 101450140 A CN101450140 A CN 101450140A
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Abstract
The invention discloses a preparation method of catnip forsythinol decoction belonging to the traditional Chinese medicine technology field. In order to regress to the disease treating marrow of the traditional medicine, the preparation method of the classic catnip forsythinol decoction in the invention comprises: water extracting according to the 'obeying ancient' guiding ideology, and concentrating and granulating combining with modern technology; and a best matched preparation process parameter and applicable auxiliary materials to the catnip forsythinol decoction are summarized out. The invention not only furthest reserves the traditional medicine experiences, but also can adapt to the rapid paces of modern society by the preparation forms such as granule, tablet capsule, powder and pill.
Description
[technical field]
The invention belongs to technical field of Chinese medicines, be specifically related to a kind of schizonepetae and forsythia decoction and preparation method thereof.
[background technology]
We derive from " the Shen Shi honor is given birth to book ", are used for the wind heat clearing away of loosing clinically, detoxifying and relieving itching.We cure mainly acne disease.The pathogenic wind of side in Herba Schizonepetae, fang-feng powder muscle, the fur; The Fructus Forsythiae clearing away heat to dispel wind is separated the cardiopulmonary pyretic toxicity; The hot cool evacuation of Radix Bupleuri, liver heat removing gallbladder wind heat; The hot temperature fragrance of the Radix Angelicae Dahuricae, the lung stomach disorder due to wind pathogen that looses is cold, and all diffusing medicines are with receiving the evil merit by wind of loosing.Reuse Radix Scutellariae, the Fructus Gardeniae poison that relieves inflammation or internal heat is separated damp and hot; Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba branch that nourishes blood, blood stasis looses; Radix Platycodonis, Fructus Aurantii the lucid yang sending up gas, the turbid descending gas; Radix Glycyrrhizae is separated hundred poison and all medicines.All medicines are shared, are suitable for rosacea caused by lung-wind disease.
Monoammonium glycyrrhizinate is that monoammonium glycyrrhizinate has anti-liver poisoning by an active component that extracts in the Chinese medicine Radix Glycyrrhizae, reduces glutamate pyruvate transaminase, recovers hepatocyte function and prevents effects such as fatty change; Promote bile pigments metabolism and jaundice eliminating and Detoxication, reduce the collagen fiber hypertrophy, prevent liver cirrhosis, have antiinflammatory, antiviral and effects such as protecting liver and detoxication and raise immunity.Do not have serious adverse reaction owing to glycyrrhizic acid has the pharmacological action of glucocorticoid sample, in clinical, be widely used in treating various acute, chronic hepatitis, bronchitis and acquired immune deficiency syndrome (AIDS).Also have functions such as anti-cancer and cancer-preventing, interferon inducer and cell immunomodulator.
In recent decades, the production of Chinese herbal medicine has realized mechanization and semi-mechanization to a certain degree.Chinese medicine often is considered to that active constituent content is low, impurity is many, quality is unstable, so medication is based upon on the empirical basis more, can not integrate with modern medicine.For addressing this problem, Chinese medicine must be walked the road of extraction and purification.The extraction of Chinese medicine comprises many unit operationss such as leaching, clarification, filtration and evaporation.
[summary of the invention]
The preparation method that the purpose of this invention is to provide a kind of new schizonepetae and forsythia decoction.
Schizonepetae and forsythia decoction of the present invention, its prescription is formed each 1.5 weight portion of Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Radix Platycodonis, Fructus Aurantii Immaturus, Herba Schizonepetae, Radix Bupleuri, SHANZHIZI, Radix Rehmanniae, Radix Paeoniae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Fructus Forsythiae, Radix Glycyrrhizae 1 weight portion, its preparation method is: medical material is decocted with water 1-4 time, each 0.5-3 hour, merge decocting liquid, filter the back concentrate fluid extract, add behind the adjuvant with behind the fluidized bed granulation useful in preparing drug formulations.
The proportion of above-mentioned fluid extract is 1.14-1.30, preferred 1.20-1.25.
Above-mentioned decocting liquid can carry out centrifugation earlier, gets clarifying decocting liquid, and centrifugal rotation speed is 1500-20000 rev/min, and preferred 1500-10000 rev/min, more preferably 2000-8000 rev/min, most preferably 3000-5000 rev/min.
Above-mentioned decocting liquid can adopt the method for membrane filtration to filter.
Above-mentioned membrane filtration comprises one of filter method of employing ultrafiltration and nanofiltration or ultrafiltration and nanofiltration is used in combination.
Above-mentioned ultrafilter membrane is selected from cellulose diacetate film, three cellulose acetate membrane, cyanoethyl cellulose film, polysulfone membrane, sulfonated polysulfone membrane, poly (ether sulfone) film, sulfonated polyether sulfone film, polysulfonamides film, phenolphthalein side group polyarylsulfone (PAS) film, polyvinylidene fluoride film, polyacrylonitrile film, polyimide film, cellulose membrane, methyl methacrylate-acrylonitrile copolymer film, polyacrylonitrile-cellulose diacetate blend film, the dynamic ultrafilter membrane that forms, one of and the Modified Membrane of above-mentioned film, its molecular retention amount is below the 6000-10000.
The filter membrane aperture of above-mentioned ultrafiltration is: the 0.22-0.45 micron.
The membrane ultrafiltration device that above-mentioned ultrafiltration is adopted can be commercial doughnut or plate ultrafilter membrane separator.
Above-mentioned NF membrane molecular retention amount is 500-2000, preferred 500-1000, more preferably 700-1000.
The process of above-mentioned membrane filtration preferably with the process ultrafiltration earlier of decocting liquid, is carried out nanofiltration again.
Above-mentioned adjuvant is selected from microcrystalline Cellulose, powdery cellulose, mannitol, starch, lactose, gelatin, methylcellulose, dextrin, pregelatinized Starch, micropowder silica gel, hydroxypropyl methylcellulose, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, Polyethylene Glycol, xylitol, lactose, glucose, glycine, mannitol, tartaric acid, silicon dioxide, one or more in calcium stearate and the magnesium stearate.
The said medicine preparation comprises granule, tablet, capsule, powder, drop pill.
The at present used extracting technique of Chinese medicine compound recipes that adopt certain density ethanol extraction Chinese medicine more, help reclaiming solvent like this and reduce impurity, but the method that adopts alcohol extraction has deviated from the experience accumulation of the treatment disease of Chinese medicine since 3000, has ignored for the purpose that can arrive " quality controllable " comparatively simply under the guiding theory of " modernization of Chinese medicine " " effectiveness " even " safety ".
In sum, the hysteresis of Chinese medicine extraction separating technology development becomes the bottleneck of traditional Chinese medicine development and existence, must be optimized, reform and strengthen original technology.The reinforcement technique of chemical separating and mass transfer will provide strong assurance for this reason, and realization Chinese medicine subject intersects with Chemical Engineering, will help realizing the modernization of Chinese medicine production equipment.With the Chinese medicine extraction separation process that induces one of notion, the theory of Chemical Engineering.Utilize available research achievements,,, technological process, production equipment, operating condition are done modernization overlay and careful groping, provided feasible scheme from basic influence factor's research staff in conjunction with the concrete condition that Chinese medicine is produced.
In order to return the marrow of traditional medicine treatment disease, the present invention proposes the guiding theory according to " abiding by Gu " with Herba Schizonepetae Forsythiae Decoction classics side, use the water extraction medicine, concentrated, granulating process in conjunction with modern have summed up the preparation process parameter and the suitable adjuvant that mate the most with schizonepetae and forsythia decoction.Kept the experience accumulation of traditional medicine to greatest extent, and it is allegro as dosage forms such as tablet, capsule, granule, powder, drop pills to adapt to modern society, for the innovation of traditional medicine provides a kind of new method and thinking.
[specific embodiment]
Following embodiment further describes the present invention, but described embodiment only is used to illustrate the present invention rather than restriction the present invention.Prescription is Rhizoma Coptidis, Radix Glycyrrhizae, Rhizoma Zingiberis, Radix Ginseng, Cortex cinnamomi japonici (Ramulus Cinnamomi), each 30 gram of Fructus Jujubae, the Rhizoma Pinelliae 60 grams in following examples.
Embodiment 1
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 2 hours, amount of water was 10 times of medical material, merge the water extract, filter decompression and solvent recovery, get fluid extract (proportion is 1.14-1.25), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 2
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 4 times with water extraction, each 1 hour, amount of water was 10 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.20-1.25), adds adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 3
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 2 hours, amount of water was 6 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.14-1.25), adds adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 4
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 3 hours, amount of water was 8 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.26-1.30), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 5
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 2.5 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.15-1.28), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 6
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 1.5 hours, amount of water was 6 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.28-1.30), add adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 7
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 2 hours, amount of water was 8 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.28-1.30), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Embodiment 8
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 2 hours, amount of water was 12 times of medical material, merge the water extract, filter decompression and solvent recovery, get fluid extract (proportion is 1.15-1.18), add adjuvant boiling granulating in fluid bed, promptly get granular preparation of the present invention.
Embodiment 9
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 2 hours, amount of water was 8 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.15-1.21), add adjuvant boiling granulating in fluid bed, encapsulated, promptly obtain capsule preparations of the present invention.
Embodiment 10
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 2 hours, amount of water was 10 times of medical material, merged the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.16-1.19), adds adjuvant boiling granulating in fluid bed, add the adjuvant tabletting, promptly obtain tablet of the present invention.
Embodiment 11
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 3 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.20-1.26), add adjuvant boiling granulating in fluid bed, add vegetable oil substrate, pill promptly obtains drop pill of the present invention.
Embodiment 12
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 2 times with water extraction, each 2.5 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.19-1.25), add adjuvant boiling granulating in fluid bed, add 200 gram vegetable oil, mix homogeneously promptly obtains soft capsule of the present invention with being pressed into soft capsule after the colloid mill grinding.
Embodiment 13
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 1.5 hours, amount of water was 10 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.20-1.24), add adjuvant boiling granulating in fluid bed, pulverize, promptly obtain powder of the present invention.
Embodiment 14
Take by weighing the pulverizing medicinal materials of recipe quantity, decoct 3 times with water extraction, each 2 hours, amount of water was 6 times of medical material, merge the water extract, filter, decompression and solvent recovery gets fluid extract (proportion is 1.18-1.23), add adjuvant boiling granulating in fluid bed, add sodium carboxymethyl cellulose, tabletting promptly obtains dispersible tablet of the present invention.
Experimental example 1-toxicologic study
(1) acute toxicity: this product is given mouse gavaging, and twice (the upper and lower noon respectively once) observed 14 days continuously in one day, and its maximum tolerated dose is 240 grams (embodiment 6)/kilogram.This product to the mouse peritoneal injection was once observed 14 days continuously, and its LD50 is 10.48 grams (embodiment 6)/kilogram.
(2) long term toxicity research: this product was irritated stomach rat 120,60,30 grams in continuous 180 days. and kilogram-1.d crude drug (large, medium and small) three dosage groups, matched group is given distilled water, and drug withdrawal convalescent period observation 30 days.Successive administration 180 days, the outward appearance sign of three dosage treated animals, behavioral activity Non Apparent Abnormality.The feedstuff day consumption increases with body weight, and each treated animal does not have significant difference to feed consumption.(0 day) ratio before administration 180 days and the administration, the weight average growth: heavy dose of 205.35 grams, middle dosage 207.24 grams, low dose 218.92 restrain, matched group 240.63 grams, and heavy dose of group body weight is omited lower than low dose and matched group, with middle dosage group basically identical.
Administration 90,180 days, drug withdrawal was observed 30 days, the relatively more equal no difference of science of statistics of large, medium and small dosage group peripheral hemogram inspection index and 10 indexs of blood biochemistry checking and matched group (P〉0.05), peripheral hemogram, blood biochemistry checking, data all fluctuate in normal range, no abnormality seen.
Each treated animal of anatomic observation, except that have the individual animal lung tissue have naked eyes as seen unusually, other is organized does not all have the visible pathological changes of naked eyes; More equal no difference of science of statistics between each organ coefficient group.
Administration 90,180 days, drug withdrawal 30 days, histopathological examination, heavy dose of group and matched group, the heart, liver, spleen, lung, kidney, brain (cerebellum), spinal cord, hypophysis, esophagus, trachea, lymph node, thyroid, thymus,, pancreas, adrenal gland, testis (epididymis), prostate, uterus, ovary, stomach, duodenum, return, colon, bladder body, more than all acellular form of each organs and tissues, textural anomaly changes.
Conclusion: in sum, the quality standard of this product is controlled, and end product quality is basicly stable; Acute toxicity testing shows that this product oral administration is 240 grams (embodiment 6)/kilogram to the mice maximum tolerated dose, and 180 days long term toxicity test shows this medicine safety non-toxic.Therefore, result of study meets the new drug requirement substantially.
Determining of the amount of experimental example 2-dry extract of the present invention
Fluid extract with the embodiment 1-14 among the present invention does not add adjuvant, and directly lyophilization obtains dry extract, and data are as follows:
By realization of the present invention, can be under the prerequisite that the effective ingredient in the Herba Schizonepetae Forsythiae Decoction is extracted to greatest extent, reducing in the extract macromolecular substances such as impurity such as tannin, polyphenol, resin, protein, phlegmatic temperament and solid particle effectively removes, keep the active ingredient in the medical material, for the preparation of oral drug preparation is provided convenience.
Monoammonium glycyrrhizinate assay in the experimental example 3-dry extract of the present invention
1 material and instrument
1.1 material
Embodiment 1-14 fluid extract (not adding adjuvant) is lyophilization gained dry extract directly.Methanol is chromatographic grade; Other reagent is analytical pure.
1.2 instrument
SPD-10AVP type high performance liquid chromatograph (day island proper Tianjin company); LibrorAEG-200 electronic balance (day island proper Tianjin company); LS-3120 supersonic generator (U.S. scientific system company).
2 assays
2.1 chromatographic condition
Chromatographic column: Kromasil C18 (4.6 * 200mm, 5 μ m); Detect wavelength according to " one one of Chinese pharmacopoeia version in 2000 is selected 250nm; Mobile phase: methanol-0.2mol/l ammonium acetate-glacial acetic acid (65: 35:1); Flow velocity: 1.0ml/min; Column temperature: 40 ℃.
2.2 reagent
Methanol (chromatographically pure), ammonium acetate (analytical pure), glacial acetic acid (analytical pure), distilled water, monoammonium glycyrrhizinate reference substance U.S. Sigma company provides, lot number 364125 140902
2.3 chromatograph employment and suitability test (E ﹠ ST)
Theoretical cam curve n=5.54 (tR/Wh/2) 2=6922.31 illustrates that under selected condition some condition of chromatographic column such as column length, carrier property and chromatographic column are filled and all met the requirements, and measure respond well.
Separating degree R=2 (tR2-tR1)/(W1+W2)=5.80, the Chinese Pharmacopoeia regulation, separating degree should be greater than 1.5, and this is measured and result of calculation, and separating degree meets the requirements.
Tailing factor fs=W0.05h/2d1=1.03 presses the Chinese Pharmacopoeia regulation, and tailing factor should be between 0.95-1.05, and this is measured and result of calculation, meets the requirements.
2.4 the investigation of the range of linearity
The preparation precision of reference substance stock solution takes by weighing monoammonium glycyrrhizinate reference substance 50mg, puts in the 50ml measuring bottle, adds dissolve with methanol and is diluted to scale, shakes up, and makes the solution that every 1ml contains 1mg, in contrast the product stock solution.The accurate above-mentioned reference substance stock solution (1mg/1ml) 0.1,0.5,1.0,2.0,5.0,8.0 of drawing, 10.0ml puts in the 10ml measuring bottle, adds methanol and is diluted to scale, shakes up.The therefrom accurate respectively 10 μ l that draw inject chromatograph of liquid, the record peak area.With sample introduction concentration (mg/1ml) is abscissa, and peak area is that vertical coordinate returns, and gets the standard curve equation to be: A=34315.5+5850054.7C r=0.9998 the results are shown in Table 1.
Table 1 linear relationship experimental result
Above result shows that in 0.01 mg/ml-1.00 mg/ml scope, monoammonium glycyrrhizinate peak area and sample introduction concentration have good linear relationship.
2.5 the preparation of need testing solution
2.5.1 the preparation of reference substance solution: precision takes by weighing monoammonium glycyrrhizinate reference substance 50mg, put in the 50ml measuring bottle, add dissolve with methanol and be diluted to scale, shake up, accurate again absorption 10ml puts in the 50ml measuring bottle, adds dissolve with methanol and is diluted to scale, shakes up, make the solution that every 1ml contains 0.2mg, in contrast product solution.
2.5.2 the preparation of need testing solution: get the about 2.5g of sample of the present invention (embodiment 1-14), porphyrize.Precision takes by weighing, and puts in the 50ml measuring bottle, adds the about 45ml of methanol, and supersound extraction is 60 minutes respectively, the cooling back is diluted to scale with methanol, shakes up, and leaves standstill, and gets supernatant and filters with microporous filter membrane (0.45 μ m), discard filtrate just, get subsequent filtrate 10 μ l, inject chromatograph of liquid, the results are shown in Table 2.
Table 2 extractum content detection
3.1 methodology examination
3.1.1 the same batch sample of stability experiment (lot number: 040210) make test liquid according to above-mentioned 3.2 methods, every the 2h sample introduction once, and each 10 μ l, the RSD=1.88% of 5 sample introduction peak areas, the relation of sample injection time and peak area sees Table 3.
Table 3 stability experiment result
3.8.2 determination of recovery rates adopts standard addition method to measure the response rate.Precision takes by weighing test sample, and (lot number: 040210) about fine powder 1.2g, put in the 50ml measuring bottle, add the about 45ml of methanol, supersound extraction 30min is diluted to scale with methanol after the cooling, shakes up.Draw above-mentioned solution 1ml respectively, totally 10 parts, put respectively in the 10ml measuring bottle, first part as blank recovery, all the other divide three groups, and every group adds monoammonium glycyrrhizinate reference substance solution 1.0ml, 1.5ml, the 2.0ml that concentration is 1 mg/ml respectively, be diluted to scale with methanol.Supernatant filters with microporous filter membrane (0.45 μ m), gets subsequent filtrate as need testing solution.
It is 98.01% (n=9) that the average recovery rate of three concentration is respectively the average recovery rate of measuring for 99.20%, 97.66% and 97.17%, 9 time, and RSD% is 1.16%.
3.1.3 precision embodiment 1 uses the content assaying method replication at different time (every 2h) on the same day respectively, the RSD% that calculates content is 1.36%; Embodiment 3 use the content assaying method replication (continuously 5d) not on the same day respectively, and the RSD% of calculating content is 1.69%.
3.2 minimum detectable level is measured
The monoammonium glycyrrhizinate reference substance solution that compound concentration is suitable, sample introduction 10 μ l, when signal to noise ratio S/N was 3, its minimum detectable concentration was about 100ng/ml.
3.3 quantitative limit is measured
The monoammonium glycyrrhizinate reference substance solution that compound concentration is suitable, sample introduction 10 μ l, when signal to noise ratio S/N was 10, its minimum detectable concentration was 500ng/ml.
3.4 ten batch samples are measured
Every batch of ten batch sample repeat secondary, press the need testing solution preparation method and handle, and sample introduction 10 μ l inject chromatograph of liquid respectively, according to " (appendix VI D) external standard method of Chinese pharmacopoeia version in 2000 is with calculated by peak area content.
4 conclusions: guaranteed the stable content of monoammonium glycyrrhizinate among the present invention, for the standardization production of preparation is laid a good foundation.
Claims (9)
1. the preparation method of a schizonepetae and forsythia decoction, its prescription consists of each 1.5 weight portion of Radix Scutellariae, Cortex Phellodendri, Rhizoma Coptidis, Radix Platycodonis, Fructus Aurantii Immaturus, Herba Schizonepetae, Radix Bupleuri, SHANZHIZI, Radix Rehmanniae, Radix Paeoniae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Herba Menthae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae and Fructus Forsythiae, Radix Glycyrrhizae 1 weight portion, it is characterized in that, medical material is decocted with water 1-4 time, each 0.5-3 hour, merge decocting liquid, filter the back concentrate fluid extract, add behind the adjuvant with behind the fluidized bed granulation useful in preparing drug formulations.
2. the preparation method of Herba Schizonepetae Forsythiae Decoction according to claim 1, the proportion that it is characterized in that described fluid extract is 1.14-1.30.
3. the preparation method of Herba Schizonepetae Forsythiae Decoction according to claim 2, the proportion that it is characterized in that described fluid extract is 1.20-1.25.
4. the preparation method of Herba Schizonepetae Forsythiae Decoction according to claim 1 is characterized in that described decocting liquid can carry out centrifugation earlier, gets clarifying decocting liquid, and centrifugal rotation speed is 1500-20000 rev/min.
5. according to the preparation method of the arbitrary described Herba Schizonepetae Forsythiae Decoction of claim 1-4, it is characterized in that described decocting liquid can adopt the method for membrane filtration to filter.
6. the preparation method of Herba Schizonepetae Forsythiae Decoction according to claim 5 is characterized in that described membrane filtration comprises ultrafiltration and nanofiltration.
7. the preparation method of Herba Schizonepetae Forsythiae Decoction according to claim 6, the process that it is characterized in that described membrane filtration is carried out nanofiltration again for the process ultrafiltration earlier of decocting liquid.
8. according to the preparation method of the arbitrary described Herba Schizonepetae Forsythiae Decoction of claim 1-7, it is characterized in that described adjuvant is selected from microcrystalline Cellulose, powdery cellulose, mannitol, starch, lactose, gelatin, methylcellulose, dextrin, pregelatinized Starch, micropowder silica gel, hydroxypropyl methylcellulose, cross-linking sodium carboxymethyl cellulose, carboxymethyl starch sodium, Polyethylene Glycol, xylitol, lactose, glucose, glycine, mannitol, tartaric acid, silicon dioxide, one or more in calcium stearate and the magnesium stearate.
9. according to the preparation method of the arbitrary described Herba Schizonepetae Forsythiae Decoction of claim 1-7, it is characterized in that described pharmaceutical preparation comprises granule, tablet, capsule, powder, drop pill.
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| CN103127293A (en) * | 2013-03-09 | 2013-06-05 | 赵明贵 | Traditional Chinese medicine composition for treating allergic conjunctivitis |
| CN103585553A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Medicine for treating summer fever of children |
| CN103585559A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Preparation method of medicine for treating summer fever of children |
| CN103585557A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Medicine for treating summer fever of children |
| CN103585558A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Medicine for treating summer fever of children |
| CN103585555A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Preparation method of medicine for treating summer fever of children |
| CN103585556A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Medicine for treating summer fever of children |
| CN103585552A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Preparation method of medicine for treating summer fever of children |
| CN103585549A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Medicine for treating summer fever of children |
| CN103585550A (en) * | 2013-11-22 | 2014-02-19 | 武汉鸿信通科技有限公司 | Preparation method of medicine for treating summer fever of children |
| CN103585550B (en) * | 2013-11-22 | 2015-10-28 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585557B (en) * | 2013-11-22 | 2015-10-28 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN103585556B (en) * | 2013-11-22 | 2015-12-02 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN103585555B (en) * | 2013-11-22 | 2015-12-02 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585552B (en) * | 2013-11-22 | 2015-12-09 | 武汉鸿信通科技有限公司 | The preparation method for the treatment of Infantile Summer Fever medicine |
| CN103585553B (en) * | 2013-11-22 | 2015-12-30 | 武汉鸿信通科技有限公司 | The medicine for the treatment of Infantile Summer Fever |
| CN115813992A (en) * | 2022-11-30 | 2023-03-21 | 四川彩虹制药有限公司 | Extraction process of schizonepeta in schizonepeta japonica/saposhnikovia divaricata particles |
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