CN101439175A - Chinese medicine preparation for treating nephropathogenic infectious bronchitis in chicken - Google Patents
Chinese medicine preparation for treating nephropathogenic infectious bronchitis in chicken Download PDFInfo
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- CN101439175A CN101439175A CNA2008101641089A CN200810164108A CN101439175A CN 101439175 A CN101439175 A CN 101439175A CN A2008101641089 A CNA2008101641089 A CN A2008101641089A CN 200810164108 A CN200810164108 A CN 200810164108A CN 101439175 A CN101439175 A CN 101439175A
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Abstract
The invention provides a traditional Chinese medicine prepration for treating avian nephropathogenic infectious bronchitis, and the active ingredients thereof are prepared by the following raw materials according to the mixture ratio by weight: 80-120 parts of heartleaf houttuynia herb, 60-100 parts of tatarian aster root, 50-70 parts of perilla leaf, 40-60 parts of sea-ear shell, 40-60 parts of cassia seed, 35-60 parts of swordlike atractylodes rhizome, 30-60 parts of platycodon root, 30-50 parts of airpotato yam rhizome, 30-50 parts of oriental stephania root, 30-50 parts of rhubarb, 30-50 parts of membranous milkvetch root, 30-50 parts of tangerine peel, 30-40 parts of lightyellow sophora root, 20-40 parts of liquoric root, 20-40 parts of cape jasmine fruit, 20-40 parts of turmeric root-tuber, 20-40 parts of Sanxian and 20-40 parts of Chinese gentian. The medicine can effectively treat the avian nephropathogenic infectious bronchitis, the cure rate is more than 90 percent, and the medicine has difficult recurrence, obvious effect, convenient administration, no toxicity or side effects, safe use and low price. Bacteria have difficulty generating the drug resistance by using the medicine, thereby avoiding the occurrence of veterinary drug residues and social public harms.
Description
Technical field
The invention belongs to beastly birds medication preparation field, relate to a kind of special effect Chinese preparation for the treatment of Nephropathogenic infectious bronchitis.
Background technology
Nephropathogenic infectious bronchitis is a kind of a kind of acute, the contagious disease highly that combines with nephropathy with respiratory disease of having a liking for chicken that the kidney strain causes by infectious bronchitis of chicken (IBV) virus.Be used for the treatment of this sick Western medicine at present and mainly contain antibody and anti-microbial type medicine etc., Chinese medicine mainly contains astragalus polysaccharides etc., though above-mentioned Chinese medicine and western medicine has certain therapeutic effect, and the disadvantage that exists easy recurrence and can not effect a radical cure.And the antibiotic Western medicine of life-time service can produce drug resistance to beastly fowl, and then can cause that the numerical value of the intravital drug residue of beastly fowl exceeds standard, and the drug resistance of various bacteria can be transferred in the human body after having eaten the meat that has the residue of veterinary drug public hazards at last.Human body health has been caused direct harm.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of Nephropathogenic infectious bronchitis, it is a kind of pure Chinese medicinal preparation, its active component is made by following materials of weight proportions: Herba Houttuyniae 80-120, Radix Asteris 60-100, Folium Perillae 50-70, Concha Haliotidis 40-60, Semen Cassiae 40-60, Rhizoma Atractylodis 35-60, Radix Platycodonis 30-60, Rhizoma Dioscoreae Bulbiferae 30-50, Radix Stephaniae Cepharanthae 30-50, Radix Et Rhizoma Rhei 30-50, Radix Astragali 30-50, Pericarpium Citri Reticulatae 30-50, Radix Sophorae Flavescentis 30-40, Radix Glycyrrhizae 20-40, Fructus Gardeniae 20-40, Radix Curcumae 20-40, Hydrargyri Oxydum Rubrum 20-40, Radix Gentianae 20-40.
The form of pharmaceutical preparation of the present invention is a powder, and form of medication is an oral administration, the every day of twice sub-service sooner or later, and by the administration of every chicken 0.3-0.7 every day gram/kg body weight, logotype 3-5 days.
Medicine provided by the invention can effectively be treated Nephropathogenic infectious bronchitis, and cure rate reaches more than 90%, is difficult for recurrence, and effect is obvious, and taking convenience has no side effect, and is safe in utilization, low price.Use medicine of the present invention, antibacterial is difficult to produce drug resistance, has avoided the generation of residue of veterinary drug and social effects of pollution.
The specific embodiment
The present invention is described further in conjunction with specific embodiments.
Embodiment 1
Prescription and each set of dispense than (by ratio of weight and the number of copies) are: Herba Houttuyniae 80 grams, Radix Asteris 60 grams, Folium Perillae 50 grams, Concha Haliotidis 40 grams, Semen Cassiae 60 grams, Rhizoma Atractylodis 60 grams, Radix Platycodonis 60 grams, Rhizoma Dioscoreae Bulbiferae 50 grams, Radix Stephaniae Cepharanthae 50 grams, Radix Et Rhizoma Rhei 50 grams, the Radix Astragali 50 grams, Pericarpium Citri Reticulatae 40 grams, Radix Sophorae Flavescentis 30 grams, Radix Glycyrrhizae 20 grams, Fructus Gardeniae 20 grams, Radix Curcumae 20 grams, Hydrargyri Oxydum Rubrum 20 grams, Radix Gentianae 20 grams.
After said components taken by weighing by weight, with raw material routinely the coarse powder production technology make powder.
Embodiment 2
Prescription and each set of dispense than (by ratio of weight and the number of copies) are: Herba Houttuyniae 100 grams, Radix Asteris 80 grams, Folium Perillae 60 grams, Concha Haliotidis 50 grams, Semen Cassiae 50 grams, Rhizoma Atractylodis 40 grams, Radix Platycodonis 45 grams, Rhizoma Dioscoreae Bulbiferae 40 grams, Radix Stephaniae Cepharanthae 40 grams, Radix Et Rhizoma Rhei 40 grams, the Radix Astragali 40 grams, Pericarpium Citri Reticulatae 40 grams, Radix Sophorae Flavescentis 35 grams, Radix Glycyrrhizae 40 grams, Fructus Gardeniae 30 grams, Radix Curcumae 30 grams, Hydrargyri Oxydum Rubrum 30 grams, Radix Gentianae 30 grams.
After said components taken by weighing by weight, with raw material routinely the coarse powder production technology make powder.
Embodiment 3
Prescription and each set of dispense than (by ratio of weight and the number of copies) are: Herba Houttuyniae 120 grams, Radix Asteris 100 grams, Folium Perillae 70 grams, Concha Haliotidis 60 grams, Semen Cassiae 40 grams, Rhizoma Atractylodis 35 grams, Radix Platycodonis 30 grams, Rhizoma Dioscoreae Bulbiferae 30 grams, Radix Stephaniae Cepharanthae 30 grams, Radix Et Rhizoma Rhei 30 grams, the Radix Astragali 30 grams, Pericarpium Citri Reticulatae 30 grams, Radix Sophorae Flavescentis 40 grams, Radix Glycyrrhizae 60 grams, Fructus Gardeniae 40 grams, Radix Curcumae 40 grams, Hydrargyri Oxydum Rubrum 40 grams, Radix Gentianae 40 grams.
After said components taken by weighing by weight, with raw material routinely the coarse powder production technology make powder.
Embodiment 4 the present invention are to the therapeutic test of Nephropathogenic infectious bronchitis
210 of 100 age in days laying hens are got in this test, are divided into 7 groups at random,
The 1st group is infected group not, the blank group of not administration;
The 2nd group is infected and the positive controls of not administration;
The 3rd group of high dose group;
The 4th group of clinical dosage group;
The 5th group of clinical half-value dose group;
The 6th group is Chinese medicine contrast astragalus polysaccharides group;
The 7th group is Western medicine contrast H120 vaccine group.
Virus IBV, the S1 strain, the Chinese Academy of Agricultural Sciences's Harbin veterinary institute provides.Test method is that the 2-7 group is all only inoculated 0.1mL/ at 100 ages in days through eye dripping, inoculates back 2 hours 3-6 groups respectively by 1.0,0.5,0.25,1 gram/dosage feeding only; The 7th group of intramuscular injection only penetrated 0.5mL/, administration every day twice logotype sooner or later 3 days, and each group is is respectively catched and killed 6 respectively at 102,104,106,108 ages in days and is dissected.Its result: degree of injury is starkly lower than the 2nd group of positive controls behind the 3rd, 4,5 three dosage group counteracting toxic substances of (1) the present invention, and viral extinction time shifts to an earlier date relatively.Show that this medicine has the effect of obvious inhibition IBV; The 5th group is pressed down toxic effect and really is lower than the other treatment group, illustrates that its therapeutic effect hangs down relevant with dosage.(2) the immunologically competent cell quantity of three test group of medicine of the present invention shows that apparently higher than positive controls medicine of the present invention has the therapeutical effect of anti-viral, the results are shown in Table 1 and table 2.
The influence of table 1 pair serum of broilers immune indexes
The table 2 pair exponential influence of broiler immune organ
Embodiment 5 clinical trials of the present invention
The standard strain of the avian infectious bronchitis virus that test strain provides for the Chinese Academy of Agricultural Sciences's Harbin veterinary institute is diluted to 3.6*10 through increasing after bacterium is cultivated
9/ mL antibacterial pressed the inoculation of 0.1mL eye dripping and causes a disease, and inoculating back 2 hours is begin treatment.Get 210 of healthy 100 age in days laying hens, be divided into 7 groups at random.
The 1st group of negative matched group: do not inoculate, not administration is observed.
The 2nd group of positive matched group: behind the infection morbidity, not administration is observed.
The 3rd group for high dose group of the present invention, i.e. clinical dosage amount group doubly.
The 4th group is dosage group, i.e. clinical dosage group among the present invention.
The 5th group is low dose group of the present invention, i.e. clinical dosage half amount group.
The 6th group is the Chinese medicine matched group, i.e. the astragalus polysaccharides matched group.
The 7th group is western medicine group, i.e. H120 vaccine matched group.
Its route of administration is oral, and take night and morning every day, high dose group 1.0 gram/kg body weight/time, middle dosage group 0.5 gram/kg body weight/time, low dose group 0.25 gram/kg body weight/time.Successive administration 3 days, a week is observed in drug withdrawal.
Western medicine group is pressed 0.5mL/ time with the antibody H120 that Chinese veterinary drug inspection is provided, the same test group of medication number of times.Treatment between group is judged: 1, cure: prothymia, and diet and feces are normal, and it is normal to lay eggs, and internal organs are normal substantially after catching and killing, and do not have tangible pathological change.2, produce effects: spirit, diet and feces recover substantially, and it is normal substantially to lay eggs, and cuing open the inspection internal organs has slight pathological change.3, effective: ability is crossed dead closing, and spirit is poor, and appetite reduces, and cuing open the inspection internal organs has obvious pathological change.4, invalid: in the death of duration of test endopathy.Its experiment is respectively organized the drug effect result referring to table 3.
Table 3
| Group | Type | The inoculation number | The survival number | Death toll | Survival rate | Efficacy determination |
| 1 group | Negative control | 0 | 30 | 0 | 100 | |
| 2 groups | Positive control | 30 | 0 | 30 | 0 | |
| 3 groups | High dose | 30 | 27 | 3 | 90 | Produce effects |
| 4 groups | Middle dosage | 30 | 27 | 3 | 90 | Produce effects |
| 5 groups | Low dosage | 30 | 23 | 7 | 77 | Effectively |
| 6 groups | Chinese medicine | 30 | 24 | 6 | 80 | Effectively |
| 7 groups | Western medicine | 30 | 23 | 7 | 77 | Effectively |
Compare the curative effect of two dosage groups of senior middle school of the present invention apparently higher than Chinese medicine, western medicine group and low dose group by statistics.
The different treatment experiments of embodiment 6 the present invention relatively
The standard strain of the avian infectious bronchitis virus that test strain provides for the Chinese Academy of Agricultural Sciences's Harbin veterinary institute is diluted to 3.6*10 through increasing after bacterium is cultivated
9/ mL antibacterial pressed the inoculation of 0.1mL eye dripping and causes a disease, and inoculating back 2 hours is begin treatment.Get 210 of healthy 100 age in days laying hens, be divided into 7 groups at random.
The 1st group of negative matched group: do not inoculate, not administration is observed.
The 2nd group of positive matched group: behind the infection morbidity, not administration is observed.
The 3rd group for pressing embodiment 1 prescription and each set of dispense medication therapy groups than preparation, i.e. clinical dosage group.
The 4th group for pressing embodiment 2 prescriptions and each set of dispense medication therapy groups than preparation, i.e. clinical dosage group.
The 5th group for pressing embodiment 3 prescriptions and each set of dispense medication therapy groups than preparation, i.e. clinical dosage group.
Its route of administration is oral, and take night and morning every day, dosage 0.5 gram/kg body weight/time.Successive administration 3 days, a week is observed in drug withdrawal.
Treatment between group is judged: 1, cure: prothymia, and diet and feces are normal, and it is normal to lay eggs, and internal organs are normal substantially after catching and killing, and do not have tangible pathological change.2, produce effects: spirit, diet and feces recover substantially, and it is normal substantially to lay eggs, and cuing open the inspection internal organs has slight pathological change.3, effective: ability is crossed dead closing, and spirit is poor, and appetite reduces, and cuing open the inspection internal organs has obvious pathological change.4, invalid: in the death of duration of test endopathy.Its experiment is respectively organized the drug effect result referring to table 4.
Table 4
| Group | Type | The inoculation number | The survival number | Death toll | Survival rate | Efficacy determination |
| 1 group | Negative control | 0 | 30 | 0 | 100 | |
| 2 groups | Positive control | 30 | 0 | 30 | 0 | |
| 3 groups | Embodiment 1 | 30 | 27 | 3 | 90 | Produce effects |
| 4 groups | Embodiment 2 | 30 | 26 | 4 | 87 | Produce effects |
| 5 groups | Embodiment 3 | 30 | 27 | 3 | 90 | Produce effects |
The result shows: each set of dispense comparison Nephropathogenic infectious bronchitis of medicine provided by the invention all has tangible curative effect.
Claims (3)
1. Chinese medicine preparation for the treatment of Nephropathogenic infectious bronchitis, it is characterized in that: its active component is made up of following materials of weight proportions: Herba Houttuyniae 80-120, Radix Asteris 60-100, Folium Perillae 50-70, Concha Haliotidis 40-60, Semen Cassiae 40-60, Rhizoma Atractylodis 35-60, Radix Platycodonis 30-60, Rhizoma Dioscoreae Bulbiferae 30-50, Radix Stephaniae Cepharanthae 30-50, Radix Et Rhizoma Rhei 30-50, Radix Astragali 30-50, Pericarpium Citri Reticulatae 30-50, Radix Sophorae Flavescentis 30-40, Radix Glycyrrhizae 20-40, Fructus Gardeniae 20-40, Radix Curcumae 20-40, Hydrargyri Oxydum Rubrum 20-40, Radix Gentianae 20-40.
2. a kind of Chinese medicine preparation for the treatment of Nephropathogenic infectious bronchitis according to claim 1 is characterized in that: the dosage form of described medicine is a powder, and form of medication is an oral administration.
3. a kind of application of Chinese medicine preparation in preparation treatment Nephropathogenic infectious bronchitis medicine for the treatment of Nephropathogenic infectious bronchitis according to claim 1.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101641089A CN101439175A (en) | 2008-12-25 | 2008-12-25 | Chinese medicine preparation for treating nephropathogenic infectious bronchitis in chicken |
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| CNA2008101641089A CN101439175A (en) | 2008-12-25 | 2008-12-25 | Chinese medicine preparation for treating nephropathogenic infectious bronchitis in chicken |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101987117A (en) * | 2010-11-10 | 2011-03-23 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine composition for treating bacterial diseases in poultry and livestock and preparation method thereof |
| CN102205061A (en) * | 2011-05-10 | 2011-10-05 | 蒋保珍 | Medicament for treating nephropathogenic infectious bronchitis in chicken and preparation method thereof |
| CN102688457A (en) * | 2012-06-19 | 2012-09-26 | 山西双鹰动物药业有限公司 | Medicament for treating chronic respiratory disease of chicken and preparation method thereof |
| CN103432265A (en) * | 2013-09-10 | 2013-12-11 | 孙丰卿 | Traditional Chinese medicinal composition preparation for treating fever in children and preparation method thereof |
| CN104825625A (en) * | 2015-03-18 | 2015-08-12 | 云南明侍达生物科技有限责任公司 | Novel veterinary anti-inflammation agent and preparation method of same |
| CN105920173A (en) * | 2016-04-28 | 2016-09-07 | 徐州天意动物药业有限公司 | Traditional Chinese medicinal composition for treating chicken infectious bronchitis |
| CN105941850A (en) * | 2016-06-14 | 2016-09-21 | 方有菊 | Immunity-improving feed additive |
| CN106370756A (en) * | 2016-11-15 | 2017-02-01 | 中悦民安（北京）科技发展有限公司 | Detection method of traditional Chinese medicine preparation for preventing infectious bronchitis |
| CN108478668A (en) * | 2018-06-27 | 2018-09-04 | 唐山市麦瑞迪宠物医院有限公司 | It is a kind of to treat avian nephropathogenic infectious bronchitis Chinese medicine preparation and preparation method thereof |
| CN113893302A (en) * | 2021-11-29 | 2022-01-07 | 南京农业大学 | Traditional Chinese medicine composition for preventing and treating respiratory syndrome of livestock and poultry as well as preparation method and application thereof |
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2008
- 2008-12-25 CN CNA2008101641089A patent/CN101439175A/en active Pending
Cited By (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101987117B (en) * | 2010-11-10 | 2012-11-14 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine composition for treating bacterial diseases in poultry and livestock and preparation method thereof |
| CN101987117A (en) * | 2010-11-10 | 2011-03-23 | 洛阳惠中兽药有限公司 | Traditional Chinese medicine composition for treating bacterial diseases in poultry and livestock and preparation method thereof |
| CN102205061A (en) * | 2011-05-10 | 2011-10-05 | 蒋保珍 | Medicament for treating nephropathogenic infectious bronchitis in chicken and preparation method thereof |
| CN102205061B (en) * | 2011-05-10 | 2012-08-15 | 蒋保珍 | Medicament for treating nephropathogenic infectious bronchitis in chicken and preparation method thereof |
| CN102688457A (en) * | 2012-06-19 | 2012-09-26 | 山西双鹰动物药业有限公司 | Medicament for treating chronic respiratory disease of chicken and preparation method thereof |
| CN103432265A (en) * | 2013-09-10 | 2013-12-11 | 孙丰卿 | Traditional Chinese medicinal composition preparation for treating fever in children and preparation method thereof |
| CN103432265B (en) * | 2013-09-10 | 2016-08-10 | 刘春燕 | A kind of Chinese medicinal composition preparation treating fever of children and preparation method thereof |
| CN104825625B (en) * | 2015-03-18 | 2017-12-29 | 云南明侍达生物科技有限责任公司 | Antiinflammatory for animals and preparation method thereof |
| CN104825625A (en) * | 2015-03-18 | 2015-08-12 | 云南明侍达生物科技有限责任公司 | Novel veterinary anti-inflammation agent and preparation method of same |
| CN105920173A (en) * | 2016-04-28 | 2016-09-07 | 徐州天意动物药业有限公司 | Traditional Chinese medicinal composition for treating chicken infectious bronchitis |
| CN105941850A (en) * | 2016-06-14 | 2016-09-21 | 方有菊 | Immunity-improving feed additive |
| CN106370756A (en) * | 2016-11-15 | 2017-02-01 | 中悦民安（北京）科技发展有限公司 | Detection method of traditional Chinese medicine preparation for preventing infectious bronchitis |
| CN106370756B (en) * | 2016-11-15 | 2019-03-12 | 中悦民安（北京）科技发展有限公司 | A kind of detection method of Chinese materia medica preparation that preventing and treating infectious bronchitis of chicken |
| CN108478668A (en) * | 2018-06-27 | 2018-09-04 | 唐山市麦瑞迪宠物医院有限公司 | It is a kind of to treat avian nephropathogenic infectious bronchitis Chinese medicine preparation and preparation method thereof |
| CN113893302A (en) * | 2021-11-29 | 2022-01-07 | 南京农业大学 | Traditional Chinese medicine composition for preventing and treating respiratory syndrome of livestock and poultry as well as preparation method and application thereof |
| CN113893302B (en) * | 2021-11-29 | 2022-05-24 | 南京农业大学 | Traditional Chinese medicine composition for preventing and treating respiratory syndrome of livestock and poultry as well as preparation method and application thereof |
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Open date: 20090527 |