CN101432626A - 用于肌钙蛋白分析的高灵敏***和方法 - Google Patents
用于肌钙蛋白分析的高灵敏***和方法 Download PDFInfo
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- CN101432626A CN101432626A CNA2007800157720A CN200780015772A CN101432626A CN 101432626 A CN101432626 A CN 101432626A CN A2007800157720 A CNA2007800157720 A CN A2007800157720A CN 200780015772 A CN200780015772 A CN 200780015772A CN 101432626 A CN101432626 A CN 101432626A
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/06—Investigating concentration of particle suspensions
- G01N15/075—Investigating concentration of particle suspensions by optical means
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- G—PHYSICS
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- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
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- G—PHYSICS
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1486—Counting the particles
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- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/124—Sensitivity
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- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/127—Calibration; base line adjustment; drift compensation
- G01N2201/12746—Calibration values determination
- G01N2201/12761—Precalibration, e.g. for a given series of reagents
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- G—PHYSICS
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
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- G—PHYSICS
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- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
Description
cTnI(pg/ml) | 信号 | 标准差 | %变异系数(CV) |
0 | 233 | 25 | 10.8 |
1.5625 | 346 | 31 | 8.9 |
3.125 | 463 | 35 | 7.5 |
6.25 | 695 | 39 | 5.6 |
12.5 | 1137 | 61 | 5.3 |
25 | 1988 | 139 | 7.0 |
50 | 3654 | 174 | 4.8 |
100 | 5493 | 350 | 6.4 |
200 | 8264 | 267 | 3.2 |
400 | 9702 | 149 | 1.5 |
800 | 9976 | 50 | 0.5 |
校准物(fM) | 信号计数 | %变异系数(CV) |
0 | 11 | |
12 | 302 | 9 |
60 | 1341 | 8 |
300 | 4784 | 7 |
尖峰信号(pg/ml) | 回收率(平均) | 标准偏差 | %变异系数(CV) |
5 | 5.7 | 0.9 | 16 |
15 | 13.7 | 0.2 | 2 |
45 | 43 | 0.6 | 2 |
135 | 151 | 6.2 | 4 |
血清稀释度 | 预期的信号的百分率 |
1:2 | 79 |
1:4 | 87 |
1:8 | 96 |
Claims (89)
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US78930406P | 2006-04-04 | 2006-04-04 | |
US60/789,304 | 2006-04-04 | ||
US79366406P | 2006-04-19 | 2006-04-19 | |
US60/793,664 | 2006-04-19 | ||
US80862206P | 2006-05-26 | 2006-05-26 | |
US60/808,662 | 2006-05-26 | ||
US86149806P | 2006-11-28 | 2006-11-28 | |
US60/861,498 | 2006-11-28 | ||
US87298606P | 2006-12-04 | 2006-12-04 | |
US60/872,986 | 2006-12-04 | ||
PCT/US2007/008506 WO2007114947A2 (en) | 2006-04-04 | 2007-04-04 | Highly sensitive system and methods for analysis of troponin |
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