CN101416987B - Honey acid mixture, preparation and application thereof - Google Patents
Honey acid mixture, preparation and application thereof Download PDFInfo
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- CN101416987B CN101416987B CN2008100947773A CN200810094777A CN101416987B CN 101416987 B CN101416987 B CN 101416987B CN 2008100947773 A CN2008100947773 A CN 2008100947773A CN 200810094777 A CN200810094777 A CN 200810094777A CN 101416987 B CN101416987 B CN 101416987B
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Abstract
The invention relates to a method for the preparation of a honey acid-synthesizing agent and applications in the prevention of diseases, the honey acid-synthesizing agent has main raw materials as below: 15 to 45 DEG C of ethanol, 64-70% of honey, edible hydrochloric acid additive having concentration larger than or equal to 31%, and water; volume ratio thereof is: 1-10:1-70:1-9:1-97; the honey acid-synthesizing agent prepared according to the invention can prevent and treat acne (whelk), color spot (chloasma, butterfly spot, freckle), phalacrosis, skin itching, dental calculus and dermatophytosis as internal use agent and external lotion (application). The honey acid-synthesizing agent has prominent curing effect in above diseases and is safe and reliable.
Description
Technical field
The present invention relates to pharmacy, relate in particular to a kind of bee honey acid composition and preparation method and application thereof, (applying) agent is washed in for oral administration and external that is used to prevent and treat acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease.
Background technology
Acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease belong to people's commonly encountered diseases, wherein:
Acne (comedo) is more common in the teenager developmental stage, is to be grown in adolescence's small pox on the face, and acne, pimple, pustule, tuberosity etc. are arranged, and is good not too easily.Account for 1/3 of adolescence adolescence, infringements such as scleroma, cyst, sinus tract, erythema, cicatrix appear in the face skin, are the common facial skin disease of adolescence, are the formidable enemies of adolescence's face, as deal with improperly also and can form vestige.Now clinical pathogeny saying to acne is various a lot, but neither one final conclusions all, and so fundamemtal phenomena that can't the reasonable dismissal acne is comedo or obstinate at present.
Mottle (chloasma, butterfly spot, freckle) is a kind of common chromatopathy, good sending out in face, show as the symmetry pigmentation mostly, though mottle is superficial, but influence attractive in appearance, be the women one big " cardiopathia " who likes to be beautiful, its reason of the generation of mottle is very complicated, and medical circle is not clear fully as yet at present.
Between twenty and fifty and middle Laonan's are more common in alopecia, have influence on patient's physical and mental health, and its cause of disease is many, and medical circle is not also made clear and complicated, so also there is not the method for radical cure.
Skin pruritus is perplexing patient's orthobiosis dearly, this disease especially at night with night-time attack the most very, the degree of pruritus even make the patient normally to fall asleep.Severe patient ceaselessly scabies scratches just and feels better, and to skin injury severity, very easily infects.And ceaselessly scratch can not be antipruritic effectively for scabies, often has and scratch the trend that scope enlarges more more, and the damage of skin is also along with expansion.The patient with severe symptoms, mood is very easily irritated.Being the modal symptom of department of dermatologry, regrettably, why can itching, medically is not clear especially, and the definition of taking at present is, pruritus is the sensation that the mankind cause a kind of discomfort of the desire of scratching, and this definition itself just is difficult to ponder.The pathogenic factors more complicated of skin pruritus, for many years, control skin pruritus method is a lot, but all is difficult to reach promising result.
Tartar and tooth (cigarette) dirt is a kind of Chang Xianxiang, makes tooth discoloration, jaundice, blackout, and general toothbrush is all brushed, and allows people be ashamed to mention in daily life.
A kind of common fungal infection dermatoses of beriberi, the people of 70-80% has beriberi among the adult, and symptom is to play vesicle between toe, and decortication or skin whitening are wet soft, also may be erosion or pachyderma, coarse, cracking, can spread to sole and instep edge, and play is itched.
Up to the present, the medicine of existing various preventions or treatment acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease on the market, but these medicines are to preventing and treating the most of poor effect of these diseases, and have such-and-such toxic and side effects.
Summary of the invention
In order to solve the variety of issue that above-mentioned disease and medicine exist, the invention provides a kind of bee honey acid composition and preparation method thereof and the application in preventing and treating acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease.
The invention discloses a kind of bee honey acid composition, comprise following component: 15-45 ℃ ethanol, Mel, concentration 〉=31% edible hydrochloric acid additive (in Hcl), water; Its volume ratio is 1-10: 1-70: 1-9: 1-97.
Preferably, each component volume ratio is 5-10: 10-40: 2-6: 44-83 in the described bee honey acid composition.
Described ethanol is wine or the edible ethanol of alcoholic strength at the 15-45 degree; Described Mel is commercially available high-quality Mel; The edible hydrochloric acid additive (in Hcl) that described edible hydrochloric acid additive is concentration 〉=31%/or the reagent hydrochloric acid solution of 36.46 (in the molecular weight of hydrochloric acid); Described water is the boiled water that burns till of tap water or mineral water, pure water.
Described bee honey acid composition is in the application for preparing in the medicine of preventing and treating acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease.
Described bee honey acid composition also comprises and one or more treatment acnes (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, the control medicine of beriberi disease, the same usefulness of agent, to heighten the effect of a treatment or to play synergism.
Described bee honey acid composition is that (applying) dosage form or injection dosage form, tablet, capsule etc. are washed in oral liquid formulation, external, but is not limited thereto.
Described bee honey acid composition also can be applied in any solution, but be not limited thereto.
The invention also discloses a kind of preparation method of bee honey acid composition, comprise the steps:
After step 103. cooling, add Mel, edible hydrochloric acid additive solution, heat to 20-30 ℃ restir 15 minutes;
It is canned, bottled etc. that bee honey acid composition after standby can carry out, and perhaps purifies and make various medicals and health preparation.
It is considered herein that acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease mechanism of production, prevent and treat method and effect is as follows:
Acne (comedo) mechanism of production is: coagulation of QI-blood and blood stagnation expectorant knot, endocrine disturbance, skin greasing, infundibulum of hair follicle segment angle cell plastid adhesive increase, the propionibacterium acnes that opening part stops up, pilosebaceous unit is interior is bred in a large number, decompose sebum, depositing forms fat bolt class in facial hair follicle, make the smegma thing be difficult for discharging and form acne; Under anaerobic environment, formerly be stored in the hair follicle a large amount of hypertrophy breedings such as corynebacterium, produce fat dissolving enzyme, toxin; Leather bag is stopped up, the pilosebaceous unit infundibular stenosis, drains obstructed, facial blood capillary obstruction, blood circulation is obstructed.
Prevent and treat method: for oral administration: this bee honey acid composition, with vital energy regualting and blood circulation-promoting, lung-heat clearing and detoxification is main doubleization silt eliminating stagnation, endocrine regulation, expand facial leather bag, promotion hair follicle blood circulation, quicken the metabolism of blood flow and skin of face, quicken the recovery of cicatrix, remove the toxin of body accumulation from root.
External: this bee honey acid composition is a mineral acid, has the effect of sterilization, antiinflammatory, decomposition, infection, radioprotective, fat melting.Kill the antibacterial in the hair follicle, the propionibacterium acnes of skin surface can't be survived and breed, the dissolving skin greasing, sebum, lipase, fat bolt are removed face's toxin, expansion face leather bag, increase cutaneous permeability, quicken the metabolism of facial skin, discharge the smegma thing, thereby eliminate acne, reach purpose except that the tender face of Cuo.
Mottle (chloasma, butterfly spot, freckle) mechanism of production is: calcium in the blood capillary-calmodulin complex and somatomedin, make facial blood capillary obstruction, interior free yl too much makes melanin deposition in subcutaneous tissue, fine circulation between histiocyte is subjected to the resistance of becoming silted up, melanin increases and forms the mottle calmness, the epidermal area of face is the thinnest, and blood capillary is the abundantest, also the easiest formation pigmentation, the pigmentation position belongs to pigment obstacle dermatoses mainly at stratum basale.Also because some chronic diseases such as chronic hepatitis, tuberculosis etc., also can cause melanin to produce increases, and body self is got rid of melanic ability and weakened thereupon, and in a single day melanin can not in time excrete, and also can produce mottle at face in the course of time.
In addition, be liver,spleen,kidney three dirty functional disorder and hormonal changes, make the face disorder of QI and blood and fall ill.Yin and yang imbalance in the human body: depression of liver-QI causes blood stasis face; Weakness of the spleen and stomach, the QI and blood face of can not moistening, the damp and hot face that rises to forms speckle; Insufficiency of kidney-YANG, the yang-energy disperse, blood stasis forms mottle.The skin blood microcirculation is not smooth, makes cortex aging, coarse, and colour of skin obfuscation, unglazed causes the quantity of mottle to increase.When general pathological change (being endocrine regulation) takes place when, caused intravital QI-blood circulation not smooth, passages through which vital energy circulates is obstructed, cause stopping in the blood stasis, the stagnation of QI is not smooth, and painstaking effort can not arrive skin face, nutrition skin, and the melanin in the skin just can not discharge along with the eubolism of human body, so long-term, also just formed mottle.
Prevent and treat method: for oral administration: this bee honey acid composition, can effectively remove calcium in the blood capillary-calmodulin complex, invigorate blood circulation, remove internal organs knot poison to dredge gas, quality purifies the blood, improve the skin microcirculation from deep layer comprehensively, the statocyte metabolism, the metabolism of endocrine regulation, promotion leather bag blood circulation, accelerate blood flow and skin of face, facial capillary permeability is increased, leather bag is unimpeded, melanin can't be deposited on subcutaneous tissue, discharges the toxin of body accumulation, fundamentally removes the various pigmented spots that cause because of qi depression to blood stasis.
This bee honey acid composition has the effect of sterilization, antiinflammatory, decomposition, infection, radioprotective, fat melting.Eliminate skin greasing, dissolving sebum, to dredge the gas quality of invigorating blood circulation, purify the blood, expansion face leather bag, increase cutaneous permeability, leather bag is unimpeded, improve the skin microcirculation from deep layer, the metabolism of accelerate blood flow and skin of face, melanin can't be deposited on subcutaneous tissue, the toxin that discharge is accumulated, the various pigmented spots that releasing causes because of qi depression to blood stasis, the skin surface pigment can't be deposited, promote the dead cell on the skin table to come off, new cell regeneration reaches that facial color is ruddy, the colour of skin is recovered gloss.
The alopecia mechanism of production is: the head blood capillary is fine, stopped up by calcium in the blood vessel-calmodulin complex easily, influence QI-blood circulation and freely do not cause qi depression to blood stasis, cause the hypoxic-ischemic of Rhizoma Imperatae deep tissue, and make oxygen branch and nutrition can't supply to the head hair follicle, and also there are a kind of lipophagia fungus and breeding in a large number on people's the scalp, but this fungus is scalp irritation and hair follicle in obtaining nutrition and discharging metabolite process, form chronic inflammatory disease, make hair follicle atrophy gradually, systematic function fails gradually, causes the hair follicle malnutrition and alopecia.
Prevent and treat method: for oral administration: this bee honey acid composition can effectively be removed calcium in the blood capillary-calmodulin complex, with vital energy regualting and blood circulation-promoting, quality purifies the blood, promote the hair follicle blood circulation, make the increase of scalp hair follicle vascular permeability, dredging vascellum, the hair follicle that stops up begins to recover, make atrophy and downright bad hair follicle be re-inflated and bring back to life, supply with hair follicle oxygen again and divide and nutrition, hair is no longer come off, and make the scalp hair follicle recovery of alopecia unimpeded, thereby the hair that growth makes new advances.
This bee honey acid composition has the effect of sterilization, antiinflammatory, decomposition, infection, radioprotective, fat melting.Eliminate that scalp is greasy, dissolving lipase, supplement the nutrients, improve the environment of scalp, can decompose that scalp is greasy, dissolving lipase, reach hair and no longer come off.
The skin pruritus mechanism of production is: because the skin histology malnutrition, cause the epithelial cell function to reduce, drying, gauffer, atrophy take place in skin, the cortex glandular secretion of skin surface is reduced and the sweat secretion minimizing, corium can not provide sufficient gland liquid and perspiration, and epidermis hardens gradually, flexibility decrease, phenomenon that epidermis presents a kind of " drying shrinkage " is brought out " skin pruritus ".In addition, also having inhalation (inhalatio), as antibacterial, fungal infection, the change of living environment and the various materials that touched of pollen, dirt, demodicid mite and body surface, also is the common cause that causes skin pruritus.
Prevent and treat method: for oral administration: this bee honey acid composition, the Skin Cell permeability is increased, fully supply with skin-nourishing, promote cortex glandular secretion and sweat secretion, sufficient gland liquid and perspiration are provided, keep moistening of epiderm skin, just can dissolve the sensitizing factor in the skin, it is decomposed gradually, homergy by human body excretes at last, when sebaceous gland liquid that is provided by corium when epidermis and perspiration fully moistened, it had better elastic and soft and moist property, thereby reaches the purpose of curing skin pruritus.
External: this bee honey acid composition, have sterilization, antiinflammatory, anti-infective effect, wiping pruritus skin reaches the itching relieving effect, and this method is antipruritic very fast, almost takes effect immediately.
The dirty mechanism of production of tooth (cigarette): tartar is to be formed by mixed-stackings such as mucus in food debris, the saliva and antibacterials, with tooth adhere to very tight, adhere to for a long time make tooth discoloration, the jaundice general toothbrush do not fall.The tooth crock is that people have cigarette smoking for a long time, and with the form of nicotine firmly attached on the tooth, make the tooth blackening.
Prevent and treat method: the main component of tartar is calcium carbonate and magnesium hydroxide, calcium carbonate and hydrochloric acid generation decomposition reaction, and then the dissolving come off, hydrochloric acid can be removed tartar thus.Crock is alkaline, and with tart dope brush crock, the saline and alkaline decomposition that reacts is removed and got instant result.
The beriberi pathogeny is: a kind of common fungal infection dermatoses, human body skin is an immune system with unique immunologic function, and immunity degradation, the toxin of human body will accumulate, influence invades dermatophytes to the defensive ability/resistance ability of external irritant easily.Under normal circumstances, there is fungi autoeciousness at human body brothers position, but generally can not cause a disease, if required nutrient substance such as protein, fat, sugar etc. are under-supply, skin histology is degenerated, deterioration; Add the shortage of vitamin and trace element, then can not keep the skin eubolism, resist the ability drop of pathogenic bacterium invasion.The fungus that colonizes on the pedal skin is very active, and the humidity between toe is again the favorable environment of conk breeding, causes the beriberi morbidity.
Prevent and treat method: for oral administration: remove the pathogenic microorganism that produces the vitamin B1 deficiency basic reason, block the toxin of its generation, ensure sanguimotor unblocked, help the abundant absorption of nutritional labeling, thereby reach the increase immunity of organism, omnibearing adjusting viscera meridians fundamentally recover the normal immunologic function of patient's body, prevent that the endogenous disease from taking place once again, thereby take leave of bothering of beriberi.
External: because foot does not have sebaceous gland, lack and have the fatty acid that suppresses the fungus ability, and foot's hyperhidrosis, wear footgear again, local sultry, moist, to add sole cutin bed thickness and provide abundant nutrition to fungus, fungus can breed more and more, this bee honey acid composition can directly go deep into sole position keratodermatitis and kill fungus, can thoroughly cure beriberi.
Description of drawings
Fig. 1 is a preparation method flow chart of the present invention.
The specific embodiment
Below in conjunction with example, set forth the present invention.Should be understood that following example only to be used to the present invention is described and be not limited to scope of the present invention, be included in other embodiments in the claim scope, can be suitable on an equal basis.
Example 1: the bee honey acid composition that is used for preventing and treating acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease medicine.
Raw materials usedly be: 15-45 ℃ of ethanol, Mel, concentration 〉=31% edible hydrochloric acid additive, water; Its volume ratio is 1-10: 1-70: 1-9: 1-97.
Preferably, in the described bee honey acid composition by: 15-45 ℃ of ethanol, Mel, 〉=31% edible hydrochloric acid additive, water form; Its volume ratio is 5-10: 10-40: 2-6: 44-83.
Effect according to ethanol, Mel, edible hydrochloric acid additive, water, the present invention with these four kinds of solvents by a certain percentage (volume ratio), temperature to be mixed with a kind of bee honey acid composition (in scope safely and effectively) oral, in order to prevent and treat acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease.
Described ethanol can be selected from various drinks and the edible ethanol that alcoholic strength is the 15-45 degree, for example Chinese liquor, yellow wine, wine etc.; Ethanol main effect in bee honey acid composition of the present invention is: promoting blood circulation to remove obstruction in the collateral, expelling wind and cold, row medicine gesture, flavoring is rectified smelly, blood circulation promoting gently, playing syngignoscism can stimulate gastric secretion and salivation, thereby plays and be good for the stomach and relieve the pain pain, diuresis and anthelmintic effect, relieving cough and asthma, heat-clearing and toxic substances removing, sterilizing, blood circulation and channel invigorating appetite stimulator, allaying tiredness, also expansible blood vessel, blood circulation promoting, resisting cold is refreshed oneself, can be nourished the body again, life lengthening, skin-softening beauty.Make this bee honey acid composition enter human vas, organ, blood capillary fast, through focus strengthens drug effect.
The main effect in bee honey acid composition of the present invention of described Mel is: " heat clearing away also, invigorating middle warmer also, detoxifcation also, pain relieving is also ".Just having put down in writing Mel in the Shennong's Herbal of B.C. one-tenth book " obeys strong will for a long time and makes light of one's life by commiting suicide, do not prolong life always ".Fructose in the Mel and glucose also contain protein, aminoacid, vitamin, inorganic salt, organic acid etc.Fructose and glucose are the monosaccharide that people's physical ability directly absorbs, the effect with rapid recovery, relieving fatigue, raising immunity.Modern Chinese medicine thinks that Mel mainly can be prevented and treated: 1, intestinal tract disease: constipation, duodenal ulcer, colitis, child's dysentery etc.; 2, nervous system disease: insomnia, headache; 3, infected wound, burn, cold injury; 4, beauty treatment.
Described hydrochloric acid can be: edible additive edible hydrochloric acid additive, reference to standard: GB1897-1995 content (in Hcl): concentration is more than or equal to 31%, and outward appearance: colourless or yellow transparent liquid, purposes: basic chemical raw materials, fabricated food are processed.Its main effect in bee honey acid composition of the present invention is: delay and remove lipids such as cholesterol and adhere in blood vessel wall, dissolving various calcium substances deposits on blood vessel wall, dredge the energy blood vessel, help the digestion and the absorption of protein, fat, blood vessel, organ rubbish in dissolving and the removing body, sterilization, sterilization.In bee honey acid composition of the present invention, the concentration of edible hydrochloric acid additive is extremely rare, can not cause stimulation to human body, and is nontoxic, harmless, safe and reliable.
The optional white various drinkable water of described water, boiled water that burns till as tap water or mineral water, pure water; The main effect of water in bee honey acid composition of the present invention is: the effect of digesting and assimilating, drain refuse, supply with nutrition and oxygen branch, balance body temperature, keep cell function, keep lymph and blood circulation, make subcutaneous cell can fully absorb nutrient substance, and discharge metabolic waste fully, cell is metabolism constantly, allow skin recover elasticity, the vigor of keeping fit, and organ dysfunction is run well.Blood vessel, organ rubbish, toxin in the dissolve body, dilute blood, carry the effect of this bee honey acid composition and endotrophic material and medium, the concentration of edible hydrochloric acid additive in the dilution raw material makes bee honey acid composition of the present invention be controlled at one to the human body edible and in the safe and reliable scope.
Described bee honey acid composition also comprises and one or more treatment acnes (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, the control medicine of beriberi disease, the same usefulness of agent, to heighten the effect of a treatment or to play synergism.
Described bee honey acid composition is that (applying) dosage form or injection dosage form, tablet, capsule etc. are washed in oral liquid formulation, external, but is not limited thereto.
Described bee honey acid composition also can be applied in any solution, but be not limited thereto.
Bee honey acid composition of the present invention is to preventing and treating the medicine of acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease, and is safe and reliable, and definite, obvious effects are arranged.
Example 2: the preparation method of bee honey acid composition: (as Fig. 1)
After step 103. cooling, add Mel, edible hydrochloric acid additive solution, heat to 20-30 ℃ restir 15 minutes;
It is canned, bottled etc. that bee honey acid composition after standby can carry out, and perhaps purifies and make various medicals and health preparation.
Example 3: bee honey acid composition in the using method of preventing and treating acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease is:
1, acne (comedo): for oral administration: with bee honey acid composition of the present invention, the using method that is used to prevent and treat a kind of recommendation of acne (comedo) disease is: bee honey acid composition of the present invention is needed the object prevented and treated, every day average 10-20 milliliter; Divide three to four administrations, each 2.5-5 milliliter, after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water, make bee honey acid composition at every turn, become the diluted acid agent, directly take (the highest 30 degree that are no more than of water temperature), clothes get up morning once, and the morning, the 9-11 point was obeyed once, and afternoon, the 14-17 point was obeyed once, obey once before sleeping evening, one month is a course of treatment.
External: with little sweet diluted acid agent, wash one's face, morning every day, evening respectively wash once, and 10-15 milliliter warm water is joined with 1 milliliter of bee honey acid composition in the back that washes one's face, and directly spreads on the face, and apply 2-6 every day, and one month is a course of treatment.
2, mottle (chloasma, butterfly spot, freckle): for oral administration: with bee honey acid composition of the present invention, the using method that is used to prevent and treat a kind of recommendation of mottle (chloasma, butterfly spot, freckle) disease is: bee honey acid composition is needed the object of control, every day average 10-20 milliliter; Divide three to four administrations, each 2.5-5 milliliter, after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water at every turn, make bee honey acid composition become the diluted acid agent, directly take (the highest 30 degree that are no more than of water temperature), get up clothes morning once, the morning, the 9-11 point was obeyed once, afternoon, the 14-17 point was obeyed once, obeyed once before sleeping evening, and one month is a course of treatment.
External: with little sweet diluted acid agent, wash one's face, morning every day, evening respectively wash once, and 10-15 milliliter warm water is joined with 1 milliliter of bee honey acid composition in the back that washes one's face, and directly spreads on the face, and apply 2-6 every day, and one month is a course of treatment.
3, alopecia: for oral administration: with bee honey acid composition of the present invention, the using method that is used to prevent and treat a kind of recommendation of alopecia is: bee honey acid composition is needed the object prevented and treated, every day average 10-20 milliliter; Divide three to four administrations, each 2.5-5 milliliter, after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water at every turn, make bee honey acid composition become the diluted acid agent ", directly take (the highest 30 degree that are no more than of water temperature), get up clothes morning once; the morning, the 9-11 point was obeyed once; afternoon, the 14-17 point was obeyed once, sleep preceding clothes evening once, three months is a course of treatment.
External: get bee honey acid composition 20-25 milliliter, pour wash basin into, add about warm water 1000-2000 milliliter (water temperature is about 30-38 ℃), hair washing is washed once every morning, and three months is a course of treatment.
4, skin pruritus: for oral administration: with bee honey acid composition of the present invention, the using method that is used to prevent and treat a kind of recommendation of alopecia is: bee honey acid composition is needed object average 10-20 milliliter every day prevented and treated; Divide three to four administrations, each 2.5-5 milliliter, after stirring with 300-500 milliliter eliminating cold for resuscitation water or mineral water, make bee honey acid composition at every turn, become the diluted acid agent "; directly take (the highest 30 degree that are no more than of water temperature); get up clothes morning once, the morning, the 9-11 point was obeyed once, and afternoon, the 14-17 point was obeyed once; sleep preceding clothes evening once, seven days is a course of treatment.
External application: with bee honey acid composition of the present invention, the method that is used to prevent and treat a kind of recommendation of skin pruritus is: get 5 milliliters of bee honey acid compositions, add warm water 10-20 milliliter, spread on patient's pruritus place every day and wipe examination, every interval was applied once in 10 minutes, and continuous three times, seven days is a course of treatment.
5, tooth (cigarette) dirt: with bee honey acid composition of the present invention, the using method that is used for removing a kind of recommendation of tooth (cigarette) dirt is: get one of bee honey acid composition of the present invention, adding water 20-30 milliliter sucks, at the oral cavity rinsing the mouth but do not tell, denture all is immersed in little sweet diluted acid agent, sucking 3 minutes spues, dripping 5 bee honey acid compositions on toothbrush directly scrubbed 2 minutes, dripping 5 bee honey acid compositions once more on toothbrush directly scrubbed 2 minutes, gargle every day each 1 time sooner or later, continuous three ∽ five days at last with warm water, tooth (cigarette) dirt can remove, and certain 100% is white.
6, beriberi: with bee honey acid composition of the present invention, the using method that is used to prevent and treat a kind of recommendation of beriberi is: get bee honey acid composition 15-35 milliliter of the present invention, add about warm water 2000-3000 milliliter (30-38 ℃), pour foot basin into, foot, hands are put into foot washing basin to be soaked about 10-15 minute, wash once before sleeping every night, connect and washed 3-10 days, the recovery from illness of 100% beriberi.
Example 4: the curative effect of bee honey acid composition of the present invention: be used to prevent and treat the prevention effect of acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease for bee honey acid composition of the present invention is described, the present invention is for oral administration to 212 examples, the patient of external slurry mixture acid has carried out clinical observation, wherein male's 100 examples, women's 112 examples, the range of age 18-68 year, 43.3 years old mean age; The result shows: among the 212 routine patients, two months disease recoveries of oral administration and externally are in 110 examples of normal level; Six months disease recoveries of oral administration and externally are in 80 examples of normal level; 16 months disease recoveries of for oral administration, external are in 17 examples of normal level.
For oral administration and washout is used to prevent and treat acne (comedo), mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease, effect such as the following table of these medicines to preventing and treating acne, mottle, alopecia, skin pruritus, tartar, beriberi disease with bee honey acid composition of the present invention:
| Name | Age | Name of disease | Before the treatment | After the treatment |
| 1, Luo | 18 | Acne | Do not take effect the red pimple of face's honey cloth, a little pustule with the commercially available acne medicine several months in youth | Use the bee honey acid composition external application, 36 days, red pimple, pustule recovery from illness |
| 2, land | 18 | Comedo | Grown a lot of acnes on the face, very big, a bit bitterly, also have dense water sometimes, the bean seal, the bean hole is a lot, is difficult to see | One month, former bean bean was all got well, and not long, the color seal has not had yet yet |
| 3, Zhang | 24 | Comedo | Comedo 3 years, acne often appear in buccal and lower jaw part, and how tame pustule nodular type comedo is bad during fashion in hospitalize, do not see positive effect | Accused more in 41 days with the bee honey acid composition external application |
| 4, poplar | 28 | Comedo | Suffered from comedo 5 years, blackhead appears in forehead and buccal often, grabs to scratch and can extrude white sample thing, and is facial greasy | With bee honey acid composition external application 47 days, acne, pustule all disappearances of generation |
| 5, Wang | 27 | Chloasma | Mottle appears the year before on the face, and gradually many later on gradually heavy, and also appearance in succession of forehead, invalid after local hospitalize | With bee honey acid composition three months, the mottle color was obviously thin out, and six months, mottle all disappeared |
| 6, end certain | 37 | Chloasma | Be mottle through local hospital diagnosis before 8 years, mottle appears in buccal and forehead behind the fertility child, and the state of an illness is increasing the weight of so far, taken some vitamin Cs, | After three months, the mottle color has thin out slightly with bee honey acid composition, and after six months, mottle is obviously thin out, after eight months, and color |
| Western medicine results such as vitamin E are bad | Speckle all disappears |
| 7, Yuan | 34 | Chloasma | Mottle appears in face, is engaged in computer work, and working chloasma on the face more than 5 years, after going on business a few Nikkei Exposures to Sunlight in July, 2004, chloasma occurs and increases after giving birth to child in 02 year | With Mel concentrated acid three months, mottle was obviously thin out, and six months, facial speckle disappeared substantially, after eight months, recovered normal |
| 8, journey | 35 | Butterfly spot | Facial butterfly spot 3 years, not obvious with the other medicines therapeutic effect | Three months, mottle was obviously thin out, and five months, facial speckle disappeared, |
| 9, Ma | 47 | Alopecia | Head began alopecia in 2005, once took multiple Chinese and western drugs, and effect is all not obvious | Substantially stop hair chap in six months with the alopecia in three months of Mel concentrated acid |
| 10, Wang certain | 58 | Alopecia | Crown hair is sparse.Know the difficult doctor of seborrheic alopecia, but be unreconciled to, attempted the method for much preventing and treating, all produce effects not | Just felt that scalp pomade obviously reduced in one month, hair does not come off gradually yet, 16 months, grows the thinner hair of one deck on the head |
| 11, Lee | 66 | Alopecia | Begin many places large tracts of land alopecia in August, 2002, after many places and multiple medical treatment are invalid | Hair did not just continue in three months, and 20 months, the place of alopecia grew bob |
| 12, the flood certain | 46 | Skin pruritus | Skin can be itched, and has scratched and has thought that housecoat is many, causes bleeding, and this year is more serious, and that all itches every night can't fall asleep, and applies with ointment, will be better after applying, and not all right once stopping, skin is grabbed and has been split. | External application seven days, skin has not been itched, and has not done so yet |
| 13, Zhu | 57 | Skin pruritus | Many places pachydermas such as two the back of the hand, instep, ancon, cervical region, the inflammation symmetry, it is hard to bear very to itch, once invalid with multiple medical treatment in local hospital | Obvious effects was just seen in external application in seven days, after continue two rehabilitations course of treatment of control again |
| 14, money | 68 | Skin pruritus | The whole skin pruritus, existing 7 years of desquamation, whenever the winter then pruritus more very, | Prevent and treat after 7 days, pruritus is ended entirely, and erythra goes down.Continue to use |
| Lie awake all night | Medicine is after three courses of treatment, and skin recovers original color, recovery from illness | |||
| 15, the week certain | 44 | Tartar | It is yellow that upper and lower tooth is, and 5 years, brushes teeth with toothbrush and not get better | With bee honey acid composition four the tartar full scale clearances of brushing teeth |
| 16, Zheng | 54 | Tartar | The dental surface fouling, the gingival third place presents yellow or canescence, 12 years | With bee honey acid composition four the tartar full scale clearances of brushing teeth |
| 17, be coated with certain | 62 | Tartar | Upper and lower tooth, tartar is yellowish-brown, more than 20 year | With bee honey acid composition six the tartar full scale clearances of brushing teeth |
| 18, season | 41 | The tooth crock | Smoking history there are 15 years, crock is all arranged inside and outside the last lower tooth | Brush teeth six times the full scale clearance of tooth crock with bee honey acid composition |
| 19, Zeng | 55 | The tooth crock | Smoking history there are 30 years, crock is all arranged inside and outside the last lower tooth | Brush teeth eight times the full scale clearance of tooth crock with bee honey acid composition |
| 20, Cai | 60 | The tooth crock | Smoking history there are 39 years, crock is all arranged inside and outside the last lower tooth | Brush teeth ten times the full scale clearance of tooth crock with bee honey acid composition |
| 21, high certain | 36 | Beriberi 2 years | The the 3rd and the four, the four and the 5th toe, moist between toe, dipping turns white or plays phlysis, and behind the dry desquamation, peelling off scurf is rotten to the corn face moistening, flushing, odd itching | Wash disappearances of very itching for three times of bubble hands, foot, after ten times, accuse and heal |
| 22, Chen | 42 | Beriberi 5 years | Both feet toe seam is very itched, and more so disturb sleep night, sends out obstinate during with the daktarin fashion | Wash bubble thing, foot five times, the disappearance of very itching |
| 23, Tan | 58 | Beriberi 10 years | Both feet toe seam is very itched, and the double small vesicle, and rotten to the corn face is arranged | Wash bubble thing, foot six times, accuse more |
By table as seen, bee honey acid composition of the present invention is used to prevent, acne, mottle (chloasma, butterfly spot, freckle), alopecia, skin pruritus, tartar, beriberi disease have comparatively tangible curative effect.
Should be understood that in addition after having read foregoing of the present invention, those skilled in the art can make various changes or modifications the present invention, these similar type fall within the application institute restricted portion equally.
Claims (5)
1. a bee honey acid composition is characterized in that, its raw material is: 15-45 degree ethanol, Mel, concentration are more than or equal to 31% edible hydrochloric acid additive, water; Described each volume feed is 1-10: 1-70: 1-9: 1-97.
2. bee honey acid composition as claimed in claim 1 is characterized in that, each volume feed of described bee honey acid composition is 5-10: 10-40: 2-6: 44-83.
3. bee honey acid composition as claimed in claim 1 or 2 prevents and/or treats the application of external lotion in acne, mottle, alopecia, skin pruritus, tartar, the beriberi disease in preparation.
4. bee honey acid composition as claimed in claim 1 or 2 is characterized in that, described bee honey acid composition is the external-use lotion type.
5. the preparation method of bee honey acid composition according to claim 1 is characterized in that, comprises the steps:
Step 1. is mixed ethanol, water, and reacting by heating is to 100-120 ℃, and the mixing that refluxes; Stirred 5-20 minute, and made mixed liquor;
Step 2. is filtered above-mentioned mixed liquor;
After step 3. cooling, add Mel, edible hydrochloric acid additive solution, heat to 20-30 ℃ restir 15 minutes;
Step 4. is filtered above-mentioned mixed liquor, and it is standby to form bee honey acid composition.
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| CN2008100947773A CN101416987B (en) | 2008-03-19 | 2008-05-16 | Honey acid mixture, preparation and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| PCT/CN2008/000541 WO2009094811A1 (en) | 2008-01-28 | 2008-03-19 | A royal jelly acidic mixture preparation and application thereof |
| WOPCT/CN2008/000541 | 2008-03-19 | ||
| CN2008100947773A CN101416987B (en) | 2008-03-19 | 2008-05-16 | Honey acid mixture, preparation and application thereof |
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| CN101416987B true CN101416987B (en) | 2011-06-22 |
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Citations (4)
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|---|---|---|---|---|
| CN1121850C (en) * | 1999-01-27 | 2003-09-24 | 莱雅公司 | Use of unfermented honey as decolouring agent |
| CN1268349C (en) * | 2004-11-30 | 2006-08-09 | 大连轻工业学院 | Water soluble medicament for anti inflammation, repressing bacteria, eliminating pes off smell and treating asjike, and its application |
| CN1969992A (en) * | 2006-12-01 | 2007-05-30 | 常达非 | Pharmaceutical composition for treating acne and application method thereof |
| CN101062203A (en) * | 2007-05-21 | 2007-10-31 | 王军 | Itching-relieving aucklandia root paste |
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2008
- 2008-05-16 CN CN2008100947773A patent/CN101416987B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1121850C (en) * | 1999-01-27 | 2003-09-24 | 莱雅公司 | Use of unfermented honey as decolouring agent |
| CN1268349C (en) * | 2004-11-30 | 2006-08-09 | 大连轻工业学院 | Water soluble medicament for anti inflammation, repressing bacteria, eliminating pes off smell and treating asjike, and its application |
| CN1969992A (en) * | 2006-12-01 | 2007-05-30 | 常达非 | Pharmaceutical composition for treating acne and application method thereof |
| CN101062203A (en) * | 2007-05-21 | 2007-10-31 | 王军 | Itching-relieving aucklandia root paste |
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| Title |
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