CN101407473A - Method for recycling abricycline from abricycline crystal mother liquor - Google Patents
Method for recycling abricycline from abricycline crystal mother liquor Download PDFInfo
- Publication number
- CN101407473A CN101407473A CNA200810179654XA CN200810179654A CN101407473A CN 101407473 A CN101407473 A CN 101407473A CN A200810179654X A CNA200810179654X A CN A200810179654XA CN 200810179654 A CN200810179654 A CN 200810179654A CN 101407473 A CN101407473 A CN 101407473A
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- Prior art keywords
- tetracycline
- mother liquor
- abricycline
- tsiklomitsin
- recycling
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Abstract
The invention relates to a method for recycling tetracycline from tetracycline crystallization mother liquor, which has acidification by hydrochloric acid first on the tetracycline crystallization mother liquor until pH value is 2.0 plus or minus 0.2; then multi-level enrichment is carried out with organic film roll of molecular weight of 400 until the potency of tetracycline is 8000-10000u/ml; then the concentrated solution is crystallized. The quality of tetracycline recycled by the invention can meet the quality standard of tetracycline, and the yield coefficient of tetracycline can be improved by 2-3 percent; simultaneously, tetracycline waste water can be more easily to be treated by using a biochemical method.
Description
Technical field
The invention belongs to the biological medicine technology field, particularly relate to a kind of method that from abricycline crystal mother liquor, reclaims tsiklomitsin.
Background technology
The a large amount of mother liquors that produce during abricycline crystal is produced, generally all be directly to discharge or after biochemical treatment, discharge as waste liquid, because the tsiklomitsin in the tsiklomitsin mother liquor about remaining 1000u/ml, therefore, on the one hand, contained a large amount of materials run off in the mother liquor, cause waste, because remaining tsiklomitsin has biocidal property, make its mother liquor biochemical process intractable on the other hand, environmental pollution is serious.
Summary of the invention
The objective of the invention is to overcome the defective of above-mentioned prior art, provide a kind of easier biochemical process of waste water that makes to handle, improved the method that from abricycline crystal mother liquor, reclaims tsiklomitsin of tsiklomitsin productive rate simultaneously again.
For realizing that the technical scheme that goal of the invention of the present invention is taked is:
A kind of method that from abricycline crystal mother liquor, reclaims tsiklomitsin, it is characterized in that: at first the tsiklomitsin mother liquor is carried out hcl acidifying to PH2.0 ± 0.2, be that 400 rolling organic membrane carries out multistage concentrating with molecular weight then, being concentrated into tetracycline activity is 8000～10000u/ml, and the concentrated solution crystallization gets final product.
The tsiklomitsin quality that the present invention reclaims can satisfy the quality standard of tsiklomitsin, and can make the tsiklomitsin yield improve 2～3%, and the more easy-to-use biochemical process of tetracycline wastewater is handled.
Description of drawings
Fig. 1 reclaims the process route chart of tsiklomitsin from abricycline crystal mother liquor for the present invention.
Embodiment
Earlier be that 4.8～5.0 tsiklomitsin mother liquor carries out hcl acidifying to PH2.0 ± 0.2 with PH, be that 400 rolling organic membrane carries out multistage concentrating with molecular weight then, being concentrated into tetracycline activity is 8000～10000u/ml, concentrated solution decrystallizes to such an extent that reclaim tsiklomitsin, crystallization method is with the crystallization method of tsiklomitsin, and dialyzate goes blowdown to carry out biochemical treatment.
Claims (1)
1. method that from abricycline crystal mother liquor, reclaims tsiklomitsin, it is characterized in that: at first the tsiklomitsin mother liquor is carried out hcl acidifying to PH2.0 ± 0.2, be that 400 rolling organic membrane carries out multistage concentrating with molecular weight then, being concentrated into tetracycline activity is 8000～10000u/ml, and the concentrated solution crystallization gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810179654XA CN101407473A (en) | 2008-11-28 | 2008-11-28 | Method for recycling abricycline from abricycline crystal mother liquor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA200810179654XA CN101407473A (en) | 2008-11-28 | 2008-11-28 | Method for recycling abricycline from abricycline crystal mother liquor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101407473A true CN101407473A (en) | 2009-04-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA200810179654XA Pending CN101407473A (en) | 2008-11-28 | 2008-11-28 | Method for recycling abricycline from abricycline crystal mother liquor |
Country Status (1)
| Country | Link |
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| CN (1) | CN101407473A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993043A (en) * | 2012-12-04 | 2013-03-27 | 天津大学 | Method for preparing high-purity tetracycline hydrochloride |
| CN103467344A (en) * | 2013-09-26 | 2013-12-25 | 宁夏启元药业有限公司 | Method for recovering urea from tetracycline urea compound salt crystallization mother liquor and recycling urea |
| CN103553805A (en) * | 2013-10-31 | 2014-02-05 | 宁夏启元药业有限公司 | Method for producing organic fertilizer by using erythromycin waste residue and tetracycline urea double salt mother liquor |
| CN104557605A (en) * | 2013-10-12 | 2015-04-29 | 宁夏启元药业有限公司 | Method for recovering tetracycline from tetracycline crystallization mother liquor |
| CN104724891A (en) * | 2015-03-27 | 2015-06-24 | 上海赛奥分离技术工程有限公司 | Processing method of terramycin crystallization mother liquor wastewater |
| CN108191692A (en) * | 2017-12-25 | 2018-06-22 | 安徽永生堂药业有限责任公司 | A kind of process for separation and purification of tetracycline antibiotics |
-
2008
- 2008-11-28 CN CNA200810179654XA patent/CN101407473A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102993043A (en) * | 2012-12-04 | 2013-03-27 | 天津大学 | Method for preparing high-purity tetracycline hydrochloride |
| CN102993043B (en) * | 2012-12-04 | 2015-03-04 | 天津大学 | Method for preparing high-purity tetracycline hydrochloride |
| CN103467344A (en) * | 2013-09-26 | 2013-12-25 | 宁夏启元药业有限公司 | Method for recovering urea from tetracycline urea compound salt crystallization mother liquor and recycling urea |
| CN104557605A (en) * | 2013-10-12 | 2015-04-29 | 宁夏启元药业有限公司 | Method for recovering tetracycline from tetracycline crystallization mother liquor |
| CN103553805A (en) * | 2013-10-31 | 2014-02-05 | 宁夏启元药业有限公司 | Method for producing organic fertilizer by using erythromycin waste residue and tetracycline urea double salt mother liquor |
| CN104724891A (en) * | 2015-03-27 | 2015-06-24 | 上海赛奥分离技术工程有限公司 | Processing method of terramycin crystallization mother liquor wastewater |
| CN104724891B (en) * | 2015-03-27 | 2016-09-07 | 上海赛奥分离技术工程有限公司 | A kind of processing method of oxytetracycline crystallization mother liquor waste water |
| CN108191692A (en) * | 2017-12-25 | 2018-06-22 | 安徽永生堂药业有限责任公司 | A kind of process for separation and purification of tetracycline antibiotics |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20090415 |