CN101390964A - Cataplasm of traditional Chinese medicine for treating hyperosteogeny - Google Patents
Cataplasm of traditional Chinese medicine for treating hyperosteogeny Download PDFInfo
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- CN101390964A CN101390964A CNA2008102264009A CN200810226400A CN101390964A CN 101390964 A CN101390964 A CN 101390964A CN A2008102264009 A CNA2008102264009 A CN A2008102264009A CN 200810226400 A CN200810226400 A CN 200810226400A CN 101390964 A CN101390964 A CN 101390964A
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Abstract
The invention discloses a Chinese traditional medicine cataplasma plaster used for the treatment of hyperosteogeny and belongs to the external Chinese traditional medicine preparation technical field. Effective ingredients are extracted from the raw materials of suberect spatholobus stem, fortune's drynaria rhizome, radix clematidis, Chinese taxillus twig, angelica, frankincense, ramulus cinnamomi, radix salviae miltiorrhizae, safflower, angelica dahurica, white paeony root and radix saposhnikoviae according to the different characteristics of the herbal materials and the preparation processes, then the effective ingredients are proportionally added to substrate to prepare cataplasma plaster. The cataplasma plaster has the efficacies of promoting blood circulation, dispelling wind and cold, dredging meridian and collaterals, detumescence and analgesic, has excellent flexibility and adhesiveness, so as to greatly enhance medicine release and percutaneous permeability. The cataplasma plaster has the advantages of avoiding the plaster from making clothes dirty, overcoming the defect of inconvenient application, having rapid efficacy, reducing skin allergy, facilitating the clinical popularization and application.
Description
Technical field
The invention belongs to the Chinese medicine for external application technical field, relate to a kind of Chinese medicine cataplasma, be specifically related to a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny, and its preparation technology has been done correlational study.
Technical background
Bone matrix hyperplasia is mainly in above middle age.It is generally acknowledged owing to have a delicate constitution and degenerative lesion after the middle age.Stand for a long time or walk and remain in certain posture for a long time, because the tractive or the avulsion of muscle are hemorrhage, organization of hematoma forms thorn-like sample hyperosteogeny: sclerotin produces soft tissue injury after mechanical stimulation and the wound, hemorrhage, swelling to soft tissue and causes.Hyperosteogeny belongs to the category of motherland's medical science " rheumatism involving the bone " and " muscular rheumatism ".Think the many because insufficiency of vital energy and blood of the generation of primary disease, caused by liver and kidney deficiency, wind-cold damp pathogen are invaded bone network trauma bone network, so that stagnation of QI-blood, move not smooth, stagnation of QI and blood may bring about pain.In through cloud: " the rich bone of kidney, be subjected to the essence of the five internal organs, six internal organs and hide it ", " blood stored in the liver, the tissue connected with the liver being tendon ".Hyperosteogeny is a degeneration, belongs to person in middle and old age's chronic disease.Come to one's autumn, QI and blood decays, and caused by liver and kidney deficiency is the principal element of primary disease, and the wet three evil invasion and attack of having a cold beyond adding in addition cause the meridians obturation, due to QI and blood is obstructed.Cataplasma of the present invention has the effect of blood circulation promoting and blood stasis dispelling, expelling wind and cold, meridians dredging, reducing swelling and alleviating pain, therefore the treatment primary disease there is excellent curative, through preliminary clinical experimental study, determine that it is evident in efficacy to hyperosteogeny, intervertebral disk hernia and soft tissue injury, therefore, be worth clinical expansion to use.
Summary of the invention
The object of the invention is to provide a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny, comprises its formula combination and preparation technology.
Be achieved through the following technical solutions order of the present invention:
A kind of Chinese medicine cataplasma for the treatment of hyperosteogeny, it is formulated by medicine and water-soluble base.
And water-soluble base comprises sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, glycerol, calcium carbonate, propylene glycol, ethyl hydroxybenzoate etc.; Wherein prepare the required substrate of said preparation and be by one or more mixture and the water in the above-mentioned water-soluble base and mix, but be not limited thereto.
The raw material of medicine is made up of the Chinese crude drug of following weight proportion:
40-75 parts of 50-90 parts of Radix Clematidis of 30-90 parts of Rhizoma Drynariae of Caulis Spatholobi
6-15 parts of 15-40 parts of Olibanums of 30-60 parts of Radix Angelicae Sinensis of Herba Taxilli
10-35 parts on 9-30 parts of Flos Carthamis of 15-50 parts of Radix Salviae Miltiorrhizaes of Ramulus Cinnamomi
20-60 parts of 30-70 parts of Radix Saposhnikoviaes of 25-65 parts of Radix Paeoniae Albas of the Radix Angelicae Dahuricae
1-15 parts of 1-9 parts of Borneolum Syntheticums of Mentholum
Form the raw material of medicine, its optimum weight proportioning is:
60 parts of 80 parts of Radix Clematidis of 65 parts of Rhizoma Drynariae of Caulis Spatholobi
12 parts of 30 parts of Olibanums of 45 parts of Radix Angelicae Sinensis of Herba Taxilli
20 parts on 15 parts of Flos Carthamis of 35 parts of Radix Salviae Miltiorrhizaes of Ramulus Cinnamomi
45 parts of 60 parts of Radix Saposhnikoviaes of 50 portions of Radix Paeoniae Albas of the Radix Angelicae Dahuricae
9 parts of 3 parts of Borneolum Syntheticums of Mentholum
A kind of Chinese medicine cataplasma for the treatment of hyperosteogeny, its preparation technology may further comprise the steps:
(1) get Caulis Spatholobi, Rhizoma Drynariae, Radix Clematidis, Herba Taxilli, Olibanum, the Radix Paeoniae Alba, Radix Saposhnikoviae seven flavors, be mixed in proportion, be ground into coarse powder, decoct with water, merge decoction liquor, filter, filtrate is concentrated into clear paste, and is standby;
(2) get Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Angelicae Dahuricae five tastes, be mixed in proportion, be ground into coarse powder, make the solvent percolation, collect percolate, be evaporated to clear paste with ethanol and Different concentrations of alcohol aqueous solution, standby;
(3) above-mentioned two clear paste are mixed, add Mentholum, Borneolum Syntheticum, stir, make extractum, standby;
(4) ratio in extractum and substrate is 1:3～1:8, and extractum is added in the substrate, stirs, and makes cataplasma, promptly.
Amount of water is 4～20 times in the step described in the preparation technology (1), decocts each 0.5～5 hour 1～5 time.
The relative density of gained extractum is 1.01～1.29 (50～80 ℃) in the described step (1).
The concentration of Different concentrations of alcohol aqueous solution is 40～80% in the described step (2).
The relative density of gained extractum is 1.05～1.25 (40～70 ℃) in the described step (2).
Effect of the present invention and cure mainly and be: have the effect of blood circulation promoting and blood stasis dispelling, expelling wind and cold, meridians dredging, reducing swelling and alleviating pain, evident in efficacy to hyperosteogeny, intervertebral disk hernia and soft tissue injury.
This Chinese medicine cataplasma is a kind of eutherapeutic Chinese medicine medicine for external use, possesses good pliability and tackness, can strengthen medicine releasability and transdermal characteristic widely.Also can reduce the pollution clothes, use shortcomings such as inconvenience, it is rapid to have drug effect, and the advantage that skin is irritated few is convenient to clinical application.
For proving effect of the present invention, we have carried out following preliminary clinical trial:
1. physical data
Get treatment and organize 203 examples, all belong to the out-patient.Man's 105 examples, women 98 examples: 35～70 years old age, average 52 years old; The course of disease 3 months to 15 years, average 5.2 years.If matched group 30 examples, two groups at no significant differences such as sex, age, the course of disease, cardinal symptom and sign and limb functions, has comparability, and treatment group and matched group all have local pain, and function limitation X ray examination sclerotin all has hypertrophy in various degree to sexually revise.
According to clinical symptoms the hyperosteogeny patient is divided into 2 types:
1. qi stagnation and blood stasis type, local pain, painful have a place of deciding, and a day light night is heavy, changes one's position unfavorablely because of the pain activity, and a posture can have wound to sprain history after often increasing the weight of for a long time, and the body of the tongue purple is dim, stringy pulse or heavy.
2. wind cold wetness type: limbs joint pain, joint stuffiness, Changes in weather increases the weight of, pain increase in intensity under coldness, hotly subtract white and slippery fur, deep-slow pulse slightly.
2. Therapeutic Method
Principal agent is formed: Caulis Spatholobi 65g, Rhizoma Drynariae 80g, Radix Clematidis 60g, Herba Taxilli 45g, Radix Angelicae Sinensis 30g, Olibanum 12g, Ramulus Cinnamomi 35g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Radix Angelicae Dahuricae 50g, Radix Paeoniae Alba 60g, Radix Saposhnikoviae 45g, Mentholum 3g, Borneolum Syntheticum 9g.Prepare cataplasma according to preparation technology of the present invention, for clinical use.
3. efficacy analysis
3.1. curative effect judging standard
Produce effects: subjective symptoms and sign disappear or are clearly better;
Take a turn for the better: the subjective symptoms mitigation capability improves;
Invalid: symptom does not have significant change.
3.2. therapeutic outcome
Treatment is organized in 203 examples, clinical cure 32 examples, and produce effects 153 examples, invalid 18 examples, total effective rate is 91.2%; In matched group 30 examples, clinical cure 2 examples, effective 20 examples, invalid 8 examples, total effective rate is 73.3%.Two groups of results learn processing by statistics, have significant difference (P＜0.05).
The specific embodiment of form is described in further detail foregoing of the present invention by the following examples.Following example is based on the above-mentioned subject area of the present invention, but is not limited to following example.
The specific embodiment
Embodiment 1:
Adopt following materials of weight proportions prescription:
Caulis Spatholobi 90g Rhizoma Drynariae 90g Radix Clematidis 75g
Herba Taxilli 60g Radix Angelicae Sinensis 40g Olibanum 15g
Ramulus Cinnamomi 50g Radix Salviae Miltiorrhizae 30g Flos Carthami 35g
Radix Angelicae Dahuricae 65g Radix Paeoniae Alba 70g Radix Saposhnikoviae 60g
Mentholum 9g Borneolum Syntheticum 15g
Its preparation technology may further comprise the steps:
(1) gets Caulis Spatholobi 90g, Rhizoma Drynariae 90g, Radix Clematidis 75g, Herba Taxilli 60g, Olibanum 15g, Radix Paeoniae Alba 70g, Radix Saposhnikoviae 60g, mix, be ground into coarse powder, add 10 times of amounts of water at every turn, decoct each 1 hour four times, merge decoction liquor, filter, filtrate is concentrated into 60 ℃ of heat, and to survey relative densities be 1.15 clear paste, standby;
(2) get Radix Angelicae Sinensis 40g, Ramulus Cinnamomi 50g, Radix Salviae Miltiorrhizae 30g, Flos Carthami 35g, Radix Angelicae Dahuricae 65g, mix, be ground into coarse powder, make the solvent percolation, collect percolate, and to be evaporated to 60 ℃ of heat survey relative densities be 1.16 clear paste with 60% ethanol water, standby;
(3) above-mentioned two clear paste are mixed, put coldly, add Mentholum 9g, Borneolum Syntheticum 15g, stir, make extractum, standby;
(4) preparation of substrate: in agitator, add entry, add polyacrylic acid (making that the ratio of polyacrylic acid and water is 1:3) rapidly and uniformly, and continue to stir and make transparent colloid, add the aqueous solution of triethanolamine and polyvinylpyrrolidone 50% then, stir, standby;
(5) ratio in extractum and substrate is 1:5, and extractum is added in the above-mentioned substrate, stirs, and makes cataplasma, promptly.
Embodiment 2:
Adopt following materials of weight proportions prescription:
Caulis Spatholobi 30g Rhizoma Drynariae 50g Radix Clematidis 40g
Herba Taxilli 30g Radix Angelicae Sinensis 15g Olibanum 6g
Ramulus Cinnamomi 15g Radix Salviae Miltiorrhizae 9g Flos Carthami 10g
Radix Angelicae Dahuricae 25g Radix Paeoniae Alba 30g Radix Saposhnikoviae 20g
Mentholum 1g Borneolum Syntheticum 1g
Its preparation technology may further comprise the steps:
(1) gets Caulis Spatholobi 30g, Rhizoma Drynariae 50g, Radix Clematidis 40g, Herba Taxilli 30g, Olibanum 6g, Radix Paeoniae Alba 30g, Radix Saposhnikoviae 20g, mix, be ground into coarse powder, add 8 times of amounts of water at every turn, decoct each 1 hour three times, merge decoction liquor, filter, filtrate is concentrated into 80 ℃ of heat, and to survey relative densities be 1.22 clear paste, standby;
(2) get Radix Angelicae Sinensis 15g, Ramulus Cinnamomi 15g, Radix Salviae Miltiorrhizae 9g, Flos Carthami 10g, Radix Angelicae Dahuricae 25g, mix, be ground into coarse powder, make the solvent percolation, collect percolate, and to be evaporated to 50 ℃ of heat survey relative densities be 1.24 clear paste with 80% ethanol water, standby;
(3) above-mentioned two clear paste are mixed, put coldly, add Mentholum 1g, Borneolum Syntheticum 1g, stir, make extractum, standby;
(4) preparation of substrate: in agitator, add 80 ℃ of hot water, add gelatin (making that the ratio of gelatin and water is 2: 5) rapidly and uniformly, and continue to stir and make transparent colloid; Sodium polyacrylate is scattered in (ratio is 2: 5) in the glycerol, stirs; Get above-mentioned two kinds of substrate mixings, standby;
(5) ratio in extractum and substrate is 1:6, and extractum is added in the above-mentioned substrate, stirs, and makes cataplasma, promptly.
Embodiment 3:
Adopt following materials of weight proportions prescription:
Caulis Spatholobi 65g Rhizoma Drynariae 80g Radix Clematidis 60g
Herba Taxilli 45g Radix Angelicae Sinensis 30g Olibanum 12g
Ramulus Cinnamomi 35g Radix Salviae Miltiorrhizae 15g Flos Carthami 20g
Radix Angelicae Dahuricae 50g Radix Paeoniae Alba 60g Radix Saposhnikoviae 45g
Mentholum 3g Borneolum Syntheticum 9g
Its preparation technology may further comprise the steps:
(1) gets Caulis Spatholobi 65g, Rhizoma Drynariae 80g, Radix Clematidis 60g, Herba Taxilli 45g, Olibanum 12g, Radix Paeoniae Alba 60g, Radix Saposhnikoviae 45g, mix, be ground into coarse powder, add 10 times of amounts of water at every turn, decoct each 1.5 hours three times, merge decoction liquor, filter, filtrate is concentrated into 70 ℃ of heat, and to survey relative densities be 1.18 clear paste, standby;
(2) get Radix Angelicae Sinensis 30g, Ramulus Cinnamomi 35g, Radix Salviae Miltiorrhizae 15g, Flos Carthami 20g, Radix Angelicae Dahuricae 50g, mix, be ground into coarse powder, make the solvent percolation, collect percolate, and to be evaporated to 70 ℃ of heat survey relative densities be 1.20 clear paste with 70% ethanol water, standby;
(3) above-mentioned two clear paste are mixed, put coldly, add Mentholum 3g, Borneolum Syntheticum 9g, stir, make extractum, standby;
(4) preparation of substrate: in agitator, add 80 ℃ of hot water, add sodium carboxymethyl cellulose (making that the ratio of sodium carboxymethyl cellulose and water is 1:3) rapidly and uniformly, make its complete swelling after, add 10 parts of polyvinyl alcohol then, stir, standby;
(5) ratio in extractum and substrate is 1:5, and extractum is added in the above-mentioned substrate, stirs, and makes cataplasma, promptly.
Claims (9)
1, a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny is characterized in that it is formulated by medicine and water-soluble base.
2, a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny as claimed in claim 1 is characterized in that water-soluble base comprises sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, glycerol, calcium carbonate, propylene glycol, ethyl hydroxybenzoate etc.; Wherein prepare the required substrate of said preparation and be by one or more mixture and the water in the above-mentioned water-soluble base and mix, but be not limited thereto.
3, a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny as claimed in claim 1 is characterized in that the raw material of medicine is made up of the Chinese crude drug of following weight proportion:
40-75 parts of 50-90 parts of Radix Clematidis of 30-90 parts of Rhizoma Drynariae of Caulis Spatholobi
6-15 parts of 15-40 parts of Olibanums of 30-60 parts of Radix Angelicae Sinensis of Herba Taxilli
10-35 parts on 9-30 parts of Flos Carthamis of 15-50 parts of Radix Salviae Miltiorrhizaes of Ramulus Cinnamomi
20-60 parts of 30-70 parts of Radix Saposhnikoviaes of 25-65 parts of Radix Paeoniae Albas of the Radix Angelicae Dahuricae
1-15 parts of 1-9 parts of Borneolum Syntheticums of Mentholum.
4, as claim 1,3 described a kind of Chinese medicine cataplasmas for the treatment of hyperosteogeny, it is characterized in that forming the raw material of medicine, its optimum weight proportioning is:
60 parts of 80 parts of Radix Clematidis of 65 parts of Rhizoma Drynariae of Caulis Spatholobi
12 parts of 30 parts of Olibanums of 45 parts of Radix Angelicae Sinensis of Herba Taxilli
20 parts on 15 parts of Flos Carthamis of 35 parts of Radix Salviae Miltiorrhizaes of Ramulus Cinnamomi
45 parts of 60 parts of Radix Saposhnikoviaes of 50 portions of Radix Paeoniae Albas of the Radix Angelicae Dahuricae
9 parts of 3 parts of Borneolum Syntheticums of Mentholum.
5, as the described a kind of Chinese medicine cataplasma for the treatment of hyperosteogeny of claim 1-4, it is characterized in that its preparation technology may further comprise the steps:
(1) get Caulis Spatholobi, Rhizoma Drynariae, Radix Clematidis, Herba Taxilli, Olibanum, the Radix Paeoniae Alba, Radix Saposhnikoviae seven flavors, be mixed in proportion, be ground into coarse powder, decoct with water, merge decoction liquor, filter, filtrate is concentrated into clear paste, and is standby;
(2) get Radix Angelicae Sinensis, Ramulus Cinnamomi, Radix Salviae Miltiorrhizae, Flos Carthami, the Radix Angelicae Dahuricae five tastes, be mixed in proportion, be ground into coarse powder, make the solvent percolation, collect percolate, be evaporated to clear paste with ethanol and Different concentrations of alcohol aqueous solution, standby;
(3) above-mentioned two clear paste are mixed, add Mentholum, Borneolum Syntheticum, stir, make extractum, standby;
(4) ratio in extractum and substrate is 1:3～1:8, and extractum is added in the substrate, stirs, and makes cataplasma, promptly.
6, a kind of preparation technology who treats the Chinese medicine cataplasma of hyperosteogeny as claimed in claim 5 is characterized in that amount of water is 4～20 times in the step (1), decocts each 0.5～5 hour 1～5 time.
7, a kind of preparation technology who treats the Chinese medicine cataplasma of hyperosteogeny as claimed in claim 5 is characterized in that the relative density of gained extractum in the step (1) is 1.01～1.29 (50～80 ℃).
8, a kind of preparation technology who treats the Chinese medicine cataplasma of hyperosteogeny as claimed in claim 5 is characterized in that the concentration of Different concentrations of alcohol aqueous solution in the step (2) is 40～80%.
9, a kind of preparation technology who treats the Chinese medicine cataplasma of hyperosteogeny as claimed in claim 5 is characterized in that the relative density of gained extractum in the step (2) is 1.05～1.25 (40～70 ℃).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008102264009A CN101390964A (en) | 2008-11-10 | 2008-11-10 | Cataplasm of traditional Chinese medicine for treating hyperosteogeny |
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| CNA2008102264009A CN101390964A (en) | 2008-11-10 | 2008-11-10 | Cataplasm of traditional Chinese medicine for treating hyperosteogeny |
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| CNA2008102264009A Pending CN101390964A (en) | 2008-11-10 | 2008-11-10 | Cataplasm of traditional Chinese medicine for treating hyperosteogeny |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169279A (en) * | 2015-10-12 | 2015-12-23 | 吴建国 | Traditional Chinese medicine composition for treating knee joint bone hyperplasia |
| CN106880701A (en) * | 2017-03-30 | 2017-06-23 | 贵阳中医学院 | A kind of compound osteitis bar cloth pastes the preparation method of Chinese medical concrete |
| CN108888740A (en) * | 2018-09-29 | 2018-11-27 | 尤刚 | A kind of bone strengthening ostalgia emplastrum and preparation method thereof |
-
2008
- 2008-11-10 CN CNA2008102264009A patent/CN101390964A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105169279A (en) * | 2015-10-12 | 2015-12-23 | 吴建国 | Traditional Chinese medicine composition for treating knee joint bone hyperplasia |
| CN106880701A (en) * | 2017-03-30 | 2017-06-23 | 贵阳中医学院 | A kind of compound osteitis bar cloth pastes the preparation method of Chinese medical concrete |
| CN106880701B (en) * | 2017-03-30 | 2020-08-25 | 贵阳中医学院 | Preparation method of compound traditional Chinese medicine plaster for treating osteitis |
| CN108888740A (en) * | 2018-09-29 | 2018-11-27 | 尤刚 | A kind of bone strengthening ostalgia emplastrum and preparation method thereof |
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