CN101371872B - Method for producing hard capsule using Acanthopanax senticosus and schisandra chinensis - Google Patents
Method for producing hard capsule using Acanthopanax senticosus and schisandra chinensis Download PDFInfo
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- CN101371872B CN101371872B CN2008101573096A CN200810157309A CN101371872B CN 101371872 B CN101371872 B CN 101371872B CN 2008101573096 A CN2008101573096 A CN 2008101573096A CN 200810157309 A CN200810157309 A CN 200810157309A CN 101371872 B CN101371872 B CN 101371872B
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Abstract
The invention relates to a method which utilizes acanthopanax and schisandra chinensis to prepare hard capsules, pertaining to the filed of Chinese patent medicines. The proposal is that: 1g acanthopanax extractum and 1ml fluid schisandra chinensis extractum by proportion are adopted in; the preparation process is that: (1) the acanthopanax extractum is heated to 40 DEG C-60 DEG C and diluted by water which is 0.8-1.2 times the total weight of extractum; (2) the fluid schisandra chinensis extractum is added to the solution prepared in step (1) and fully mixed; (3) ethanol is added till the ethanol accounts for 75-85 percent of the solution, fully mixed and the solution is settled for 30-40h; the supernatant is taken and the ethanol is recovered and concentrated into a clean extractum with a density of 1.25; (4) dextrin which is 0.6-0.7 time the total weight of the clean extractum and the mixture is dried and prepared into particles which are then packaged into capsules to obtain the hard capsule. The method overcomes the defects of low concentration of active ingredients in liquid preparation, inconvenient carrying and adverse affect on the clinical application, and meanwhile improves the previous capsule preparation method, causes the preparation process more reasonable, the medical effect of the prepared capsule more effective and the medicine easier to be carried with and taking.
Description
Technical field
Through clinical confirmation for many years, Chinese medicine Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis compositions have strengthening spleen, tonifying kidney, mind tranquilizing and the heart calming function.The present invention relates to utilize Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis to prepare the method for hard capsule, belong to the Chinese patent medicine manufacture field.
Background technology
Modern study shows that the Chinese medicine Radix Et Caulis Acanthopanacis Senticosi has replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization, and wind-damp dispelling, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, the invigorating middle warmer benefit is smart, strong Fructus Alpiniae Oxyphyllae, functions such as diuresis are good for the stomach.Radix Et Caulis Acanthopanacis Senticosi contains multiple acanthoside, polysaccharide isoreactivity composition, have defying age, resisting fatigue (antifatigue effect of eleutheroside is also stronger than Radix Ginseng), anticancer, with adjusting nerve, endocrine, cardiovascular function, improve the pharmacological actions such as resistivity of human body to destructive stimuluses such as physics, chemistry, biologies, in treatment of diseases such as neurasthenia, insomnia, hypertension, coronary heart disease, cerebral infarction, cerebral arteriosclerosis, climacteric syndrome, dyslipidemia, diabetes, rheumatism, chronic bronchitis and tumor, certain curative effect is arranged all.Five tastes of medicinal herb has supplementing QI for promoting the production of body fluid, the nourishing kidney of astringing the lung, antidiarrheal, arresting seminal emission, function such as calm the nerves, and can control diseases such as chronic cough dyspnea due to deficiency, the few xerostomia in Tianjin, seminal emission chronic diarrhea, forgetful insomnia.Pharmacological evaluation proof Fructus Schisandrae Chinensis can be regulated central nervous system's excitement and process of inhibition, promotes body metabolism, regulates the secretion of gastric juice and bile, and hepatitis convalescent period transaminase rising person is had the reduction effect.
The medicine that utilizes Radix Et Caulis Acanthopanacis Senticosi and Fructus Schisandrae Chinensis to mix at present to produce is because preparation technology's restriction is mainly liquid, as Radix Et Caulis Acanthopanacis Senticosi brain ichor.The mixture one of this liquid extraction preparation is to carry inconvenience, the 2nd, and the Radix Et Caulis Acanthopanacis Senticosi content that effectively becomes a common practice is low, is difficult to reach better curative effect.The applicant has asked " Chinese medicine composition of a kind of strengthening spleen, tonifying kidney, mind tranquilizing and the heart calming and preparation method " publication number CN1730062 formerly for this reason.Its technical scheme is: (Fructus Schisandrae Chinensis powder is broken into behind the coarse powder with 60% soak with ethanol 48 hours, and percolation adds ethanol with the percolation limit, speed limit of per minute 200～300ml for Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Schisandrae Chinensis fluid extract, the liquid of just filtering is preserved (not reclaiming ethanol) percolation separately till colourless substantially, reclaim ethanol, be evaporated to each portion of thick paste shape), Radix Et Caulis Acanthopanacis Senticosi extractum is warm, add the suitable quantity of water dilution, add the Fructus Schisandrae Chinensis fluid extract, stir, add ethanol and make and contain the alcohol amount and reach 80%, stir, left standstill 36 hours, and divided and get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste (50 ℃), add an amount of dextrin, drying is made granule, drying incapsulates promptly.It is on the low side that this invention has overcome present liquid preparation effective ingredient concentration, carries inconvenience, influences the shortcoming of clinical practice, makes easy to usely clinically, and patient's dose reduces.But process discovers further that to above-mentioned technology the Fructus Schisandrae Chinensis fluid extract uses 60% soak with ethanol to have the defective that soak time is long, the ethanol consumption is big and organic efficiency is low.And summing up the more practicable preparation method of a cover on this basis, the curative effect with further raising working (machining) efficiency and medicine reduces production costs.
Summary of the invention
Purpose of the present invention is exactly at existing defective in the technology formerly, provides that a kind of process conditions are more reasonable, preparation efficiency is higher, and utilize Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis easy to carry, determined curative effect prepare the method for hard capsule
Its technical scheme is: get the raw materials ready in 1g Radix Et Caulis Acanthopanacis Senticosi extractum and 1ml Fructus Schisandrae Chinensis fluid extract ratio.Preparation process is that (1) Radix Et Caulis Acanthopanacis Senticosi extractum is warm under 40-60 ℃ of condition, adds the 0.8-1.2 water dilution doubly that accounts for the extractum total amount, and (2) add the Fructus Schisandrae Chinensis fluid extract, stir, (3) add ethanol to be made and contains the alcohol amount and reach 75-85%, stirs, left standstill 30-40 hour, divide and to get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste, (4) adding accounts for clear paste gross weight 0.6-0.7 dextrin doubly, drying is made granule, incapsulates promptly.Wherein the preparation method of Fructus Schisandrae Chinensis fluid extract is to use 75-85% soak with ethanol 35-45 hour after Fructus Schisandrae Chinensis powder is broken into coarse powder, carries out percolation first; Then will be first the percolation limit, powder limit of percolation add ethanol, amount of alcohol added is by every kilogram of alcoholic acid ratio of powder adding 3-5ml, percolation to percolate colourless till; Be evaporated to the thick paste shape.
But confirm that through clinical application for many years this Chinese medicine composition determined curative effect has excellent curative to neurasthenia symptoms such as insomnia, forgetful, fatigue and weakness.In production application, though the mixture taking convenience, effective ingredient concentration is on the low side, carries, stores inconvenience, has influenced clinical practice.
Effect of the present invention: it is on the low side to have overcome present liquid preparation effective ingredient concentration, carries inconvenience, influences the shortcoming of clinical practice, carry out perfect to original capsule preparation method thereof simultaneously, make preparation technology more reasonable, the capsule drug effect of preparation is higher, and is more portable and take.
The specific embodiment
Embodiment one:
The preparation of Fructus Schisandrae Chinensis fluid extract, Fructus Schisandrae Chinensis powder are broken into behind the coarse powder with 75% soak with ethanol 48 hours, and percolation adds ethanol with percolation limit, certain speed (3ml/kgmin) limit, and percolation is evaporated to the thick paste shape till colourless substantially.Radix Et Caulis Acanthopanacis Senticosi extractum adopts existing preparation method to extract.Press the mixed of Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Schisandrae Chinensis fluid extract 1g:1ml.Radix Et Caulis Acanthopanacis Senticosi extractum and each portion of Fructus Schisandrae Chinensis fluid extract, Radix Et Caulis Acanthopanacis Senticosi extractum warm (40 ℃) adds suitable quantity of water (extractum total amount 1.2 times) dilution, add the Fructus Schisandrae Chinensis fluid extract, stir, add ethanol and make and contain the alcohol amount and reach 80%, stir, left standstill 36 hours, divide and get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste (50 ℃), add an amount of (clear paste gross weight 0.7 times) dextrin, dry, make granule, drying incapsulates promptly.
Embodiment two:
The preparation of Fructus Schisandrae Chinensis fluid extract, Fructus Schisandrae Chinensis powder are broken into behind the coarse powder with 80% soak with ethanol 48 hours, and percolation adds ethanol with percolation limit, certain speed (4ml/kgmin) limit, and percolation is evaporated to the thick paste shape till colourless substantially.Radix Et Caulis Acanthopanacis Senticosi extractum adopts existing preparation method to extract.Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Schisandrae Chinensis fluid extract are with the mixed of 1g:1ml.Radix Et Caulis Acanthopanacis Senticosi extractum and each portion of Fructus Schisandrae Chinensis fluid extract, Radix Et Caulis Acanthopanacis Senticosi extractum warm (50 ℃) adds suitable quantity of water (extractum total amount 1.0 times) dilution, add the Fructus Schisandrae Chinensis fluid extract, stir, add ethanol and make and contain the alcohol amount and reach 80%, stir, left standstill 36 hours, divide and get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste (50 ℃), add an amount of (clear paste gross weight 0.65 times) dextrin, dry, make granule, drying incapsulates promptly.
Embodiment three:
The preparation of Fructus Schisandrae Chinensis fluid extract, Fructus Schisandrae Chinensis powder are broken into behind the coarse powder with 85% soak with ethanol 48 hours, and percolation adds ethanol with percolation limit, certain speed (5ml/kgmin) limit, and percolation is evaporated to the thick paste shape till colourless substantially.Radix Et Caulis Acanthopanacis Senticosi extractum adopts existing preparation method to extract.Radix Et Caulis Acanthopanacis Senticosi extractum and Fructus Schisandrae Chinensis fluid extract are with the mixed of 1g:1ml.Radix Et Caulis Acanthopanacis Senticosi extractum and each portion of Fructus Schisandrae Chinensis fluid extract, Radix Et Caulis Acanthopanacis Senticosi extractum warm (60 ℃) adds suitable quantity of water (extractum total amount 0.8 times) dilution, add the Fructus Schisandrae Chinensis fluid extract, stir, add ethanol and make and contain the alcohol amount and reach 80%, stir, left standstill 36 hours, divide and get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste (50 ℃), add an amount of (clear paste gross weight 0.6 times) dextrin, dry, make granule, drying incapsulates promptly.
Claims (1)
1. a method of utilizing Radix Et Caulis Acanthopanacis Senticosi, Fructus Schisandrae Chinensis to prepare hard capsule is got the raw materials ready in 1g Radix Et Caulis Acanthopanacis Senticosi extractum and 1ml Fructus Schisandrae Chinensis fluid extract ratio; Preparation process is that (1) Radix Et Caulis Acanthopanacis Senticosi extractum is warm under 40-60 ℃ of condition, add the 0.8-1.2 water dilution doubly that accounts for the extractum total amount, (2) add the Fructus Schisandrae Chinensis fluid extract, stir, (3) adding ethanol makes and contains the alcohol amount and reach 75-85%, stir, left standstill 30-40 hour, divide and get supernatant, reclaim ethanol, be concentrated into relative density and be 1.25 clear paste, (4) add and account for clear paste gross weight 0.6-0.7 dextrin doubly, drying, make granule, incapsulate promptly, it is characterized in that: the preparation method of Fructus Schisandrae Chinensis fluid extract is to use 75-85% soak with ethanol 35-45 hour after Fructus Schisandrae Chinensis powder is broken into coarse powder, carries out percolation first, the percolation limit, powder limit of percolation adds ethanol first then, amount of alcohol added adds the alcoholic acid ratio of 3-5ml in every kilogram of powder, percolation to percolate colourless till, be evaporated to the thick paste shape.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101573096A CN101371872B (en) | 2008-09-23 | 2008-09-23 | Method for producing hard capsule using Acanthopanax senticosus and schisandra chinensis |
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| CN2008101573096A CN101371872B (en) | 2008-09-23 | 2008-09-23 | Method for producing hard capsule using Acanthopanax senticosus and schisandra chinensis |
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| CN101371872A CN101371872A (en) | 2009-02-25 |
| CN101371872B true CN101371872B (en) | 2011-02-09 |
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| CN104490904B (en) * | 2014-12-17 | 2018-06-08 | 黑龙江金九药业股份有限公司 | It is a kind of to treat neurasthenic pharmaceutical composition and preparation method thereof |
| CN105535113A (en) * | 2016-01-22 | 2016-05-04 | 宋亚 | Traditional Chinese medicine composition for treating radiation encephalopathy and preparing method and application of traditional Chinese medicine composition |
| CN110215494B (en) * | 2019-06-24 | 2021-10-08 | 广州中医药大学(广州中医药研究院) | Traditional Chinese medicine granules for regulating sleep and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1730062A (en) * | 2005-08-02 | 2006-02-08 | 山东仙河药业有限公司 | Chinese medicinal composition for invigorating spleen, tonifying kidney, relieving metal stress and its preparation process |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1730062A (en) * | 2005-08-02 | 2006-02-08 | 山东仙河药业有限公司 | Chinese medicinal composition for invigorating spleen, tonifying kidney, relieving metal stress and its preparation process |
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Denomination of invention: Method for producing hard capsule using Acanthopanax senticosus and schisandra chinensis Effective date of registration: 20200623 Granted publication date: 20110209 Pledgee: Dongyinghekou sub branch of Agricultural Bank of China Ltd. Pledgor: SHANDONG XIANHE PHARMACEUTICAL Co.,Ltd. Registration number: Y2020370010021 |