CN101347116A - Complex pesticide of osthole and agricultural antibiotic and uses thereof - Google Patents
Complex pesticide of osthole and agricultural antibiotic and uses thereof Download PDFInfo
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- CN101347116A CN101347116A CNA200710119304XA CN200710119304A CN101347116A CN 101347116 A CN101347116 A CN 101347116A CN A200710119304X A CNA200710119304X A CN A200710119304XA CN 200710119304 A CN200710119304 A CN 200710119304A CN 101347116 A CN101347116 A CN 101347116A
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Abstract
The present invention provides a complex pesticide of osthole and agricultural antibiotic. The effective components include osthole and agricultural antibiotic with the weight proportion of 1 to 6:1 to 8. The agricultural antibiotic is validamycin, kasugamycin or agricultural streptomycin. The complex pesticide of osthole and agricultural antibiotic provided by the present invention has the advantages of obvious additive effect, strong antibacterial activity and relatively small dosage and has obvious effect on prevention and treatment of rice sheath blight, wheat scab or rice blast.
Description
Technical field
The present invention relates to a kind of Osthole and farm antibiotics composite dose, specifically, relate to a kind ofly, belong to the botanical fungicide agriculture chemical compounding agent composite dose of farm antibioticss such as plant extracts Osthole and jinggangmeisu, kasugarnycin and uses thereof.
Background technology
Osthole is the main chemical in the common Chinese medicine material frutus cnidii, and medically, Osthole has been used to the medicine producing anti-inflammation, kill Trichomonas vaginalis.And it is anti-ageing, anti-osteoporosis, and the biologically active that antiallergy etc. are new also is in the news in succession.Common cnidium fruit P.E has been used for producing desinsection and antibiotic agricultural chemicals on agricultural.
Available data has been reported the bacteriostatic activity of Osthole to 9 plant species disease funguses and 6 plant species pathogenetic bacterias, and test data shows that Osthole has good inhibitory effect to disease funguses such as rice sheath blight disease, wheat scab, cotton seedling blight, sclerotinia rot of colza, Alternaria alternates.But carry out the result of the test of pesticide effectiveness in the land for growing field crops according to the inventor, finding that the agent of Osthole list prevents and treats the effect of above-mentioned crop pest can't be satisfactory.
The patent CN01127083.7 " application of Osthole on agricultural " of academy of agricultural sciences, Jiangsu Province stone will fine jade etc. discloses Osthole in the application of milk product aspect anticorrosion, the claim of osthole for preventing and treating eliminating vegetable botrytis, garlic leaf spot, asparagus stem wilt, black rot of pear, apple leaf rot had also once been proposed, but after be disabled.Shi Zhiqi etc. proposed the patent (application number 200410069127.5) of the composite control crop powdery mildew of the Osthole chemical bactericide synthetic with suppressing the fungi ergosterol (nitrile bacterium azoles, triazolone, Tebuconazole, propiconazole four kinds among a kind of) in 2004 again, and controlling object is cucumber, pumpkin, strawberry, mulberry leaf and grape powdery mildew.
Do not see the composite rice sheath blight disease, rice blast of preventing and treating of microbial metabolic products such as Osthole and jinggangmeisu, kasugarnycin, streptomycin open, be used for false smut, sclerotinia rot of colza, wheat scab afterwards and do not see open report and patent application yet Osthole and chemical synthetic pesticide are composite.
Summary of the invention
The purpose of this invention is to provide tangible Osthole of a kind of synergistic effect and farm antibiotics composite dose.
Another object of the present invention provides composite dose of application that is used for preparing control and treatment rice sheath blight disease, wheat scab or rice blast agricultural chemicals of Osthole and farm antibiotics.
The inventor has carried out the test of osthole for preventing and treating field crops disease on the basis of having studied the Osthole antimicrobial spectrum, find that Osthole list agent protection effect is unsatisfactory, be necessary by composite, find the pesticide combination of remarkable synergy, reach the raising control efficiency, reduce dosing, reduce the purpose of environmental pollution.For this reason, the present invention selected multiple biochemical pesticide and chemical synthetic pesticide respectively with fructus cnidii complex, filter out the very strong bactericidal pesticide composition of synergistic effect, and through potted plant or field plot trial, receive the good sterilization effect.
In order to realize the object of the invention, Osthole of the present invention and farm antibiotics composite dose, it comprises effective component of osthole and farm antibiotics, the weight ratio of the two is 1～6: 1～8; Described farm antibiotics is jinggangmeisu, kasugarnycin or streptomycin.
Wherein, preferred weight ratio is 1～4: 1～6.
Described Osthole (Osthol) is the main active ingredient of samphire frutus cnidii fruit, its molecular formula: Cl
5H
16O
3, molecular weight: 224.28, employed Osthole be adopt known method to extract to obtain than pure compound, its purity 〉=92% also can be bought from the market and obtains.
Jinggangmeisu, kasugarnycin or streptomycin are commercial acquisition, and streptomycin is agricultural streptomycin sulphate.
Osthole of the present invention and antibiotic proportioning are the weight ratio of product active ingredient.
When Osthole and composite jinggangmycin, the proportioning between Osthole and the jinggangmeisu is 1～6: 1, and the proportioning between preferred Osthole and the jinggangmeisu is 6: 1 or 4: 1.
When Osthole and kasugarnycin were composite, the proportioning between Osthole and the kasugarnycin was 1～4: 1～4, is preferably 4: 1.
When Osthole and streptomycin were composite, the proportioning between Osthole and the streptomycin was 1～2: 1～8.
Can make pesticidal preparations well known in the art for composite dose of Osthole of the present invention and farm antibiotics, such as missible oil, pulvis, aqua, suspending agent, tablet, granule etc.
Wherein, as the missible oil formulation, composite dose of Osthole of the present invention and farm antibiotics comprises following composition and content:
Active ingredient: 2-18%,
Emulsifier: 5-25%,
Bleeding agent: 1-15%,
Solvent: 40-92%.
Emulsifier is farming breast 0203 or agricultural newborn 500#, and bleeding agent is OT-99, thiophene ketone or organosilicon bleeding agent (the poly-trisiloxanes of ethyoxyl modification etc.); Solvent is N-N, dimethyl formamide, absolute ethyl alcohol or methyl alcohol.
The preparation method of missible oil is:
Earlier dissolve jinggangmeisu with partial solvent by prescription, being stirred to fully, dissolving adds Osthole afterwards.Be stirred to dissolving fully again.Again emulsifier is added and stir, add bleeding agent then.After continuing to stir 1 hour, look institute's short weight or volume and complement to institute's counterweight amount (or volume) with methyl alcohol.Continue again to stir 1 hour.
Osthole of the present invention and antibiotic composite dose of application that is used for preparing control and treatment rice sheath blight disease, wheat scab or rice blast agricultural chemicals; Wherein, Osthole and composite jinggangmycin, better for the effect of rice sheath blight disease and wheat scab; Osthole and kasugarnycin are composite, are good for the effect of rice blast; Osthole and streptomycin are composite, are good for the effect of rice sheath blight disease.
Osthole of the present invention and antibiotic composite dose, synergistic effect is obvious, and bacteriostatic activity is strong, and consumption is few relatively, for control and treatment rice sheath blight disease, wheat scab or rice blast positive effect is arranged.
Embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.The compounded cream agent of embodiment 1 Osthole and jinggangmeisu
The compounded cream agent of Osthole and jinggangmeisu contains Osthole 3%, jinggangmeisu 0.5%, and emulsifier 0,203 12%, agricultural newborn 500#2%, bleeding agent OT-99 10%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
Process for preparation:
Accurately take by weighing two kinds of effective ingredients (Osthole and jinggangmeisu) respectively by prescription, the amount of effective ingredient is all calculated by folding hundred, accurately takes by weighing various auxiliary agents and solvent N respectively, dinethylformamide.
Use earlier N, dinethylformamide dissolving jinggangmeisu, being stirred to fully, dissolving adds Osthole afterwards.Be stirred to dissolving fully again.Again emulsifier is added and stir, add bleeding agent then.After continuing to stir 1 hour, look institute's short weight or volume and complement to institute's counterweight amount (or volume) with methyl alcohol.Continue again to stir 1 hour.
The sampling and measuring effective component content, every important quality index of products such as emulsibility, the qualified product that then is packaged into.
The compounded cream agent of embodiment 2 Ostholes and jinggangmeisu
Process for preparation is with embodiment 1, and different is, Osthole 1.6%, and jinggangmeisu 0.4%, emulsifier 0,203 10%, agricultural newborn 500#2%, bleeding agent OT-99 8%, N, dinethylformamide 40%, surplus supplies 100% with absolute ethyl alcohol.
The compounded cream agent of embodiment 3 Ostholes and jinggangmeisu
Process for preparation is with embodiment 1, and different is, Osthole 8%, and jinggangmeisu 2%, emulsifier 0,203 15%, organosilicon bleeding agent (the ethyoxyl modification gathers trisiloxanes) 4%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 4 Ostholes and jinggangmeisu
Process for preparation is with embodiment 1, and different is, Osthole 4.2%, and jinggangmeisu 0.7%, emulsifier 0,203 20%, thiophene ketone 2%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 5 Ostholes and jinggangmeisu
Process for preparation is with embodiment 1, and different is Osthole 9%, jinggangmeisu 9%, emulsifier 0,203 25%, organosilicon bleeding agent 1%, N, dinethylformamide 56%.
The compounded cream agent of embodiment 6 Ostholes and kasugarnycin
The compounded cream agent of Osthole and kasugarnycin contains Osthole 1%, kasugarnycin 1%, and (amount of above two kinds of effective ingredients is folding hundred weight, down together), emulsifier 020312%, bleeding agent OT-99 10%, N, dinethylformamide 40%, surplus supplies 100% with methyl alcohol.
Process for preparation:
Earlier various active substances and auxiliary agent are accurately taken by weighing out respectively, only stay and supply the organic solvent that surplus uses and to take by weighing by prescription.
With kasugarnycin N, dinethylformamide dissolves, and being stirred to fully, dissolving adds Osthole afterwards.Be stirred to dissolving fully again.Again emulsifier is added and stir, add bleeding agent then.After the lasting stir about 1 hour, look institute's short weight or volume and complement to institute's counterweight amount (or volume) with methyl alcohol or absolute ethyl alcohol.Continue again to stir 1 hour.
Every important quality index of products such as sampling and measuring effective component content, emulsibility, the qualified product that then is packaged into.
The compounded cream agent of embodiment 7 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 2%, and kasugarnycin 2%, emulsifier 0,203 12%, bleeding agent OT-99 10%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 8 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is Osthole 6%, kasugarnycin 6%, emulsifier 0,203 12%, agricultural newborn 500#2.5%, organosilicon bleeding agent (the ethyoxyl modification gathers trisiloxanes) 4%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 9 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 1%, and kasugarnycin 2%, emulsifier 0,203 10%, bleeding agent OT-99 10%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 10 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 2%, and kasugarnycin 1%, emulsifier 0,203 8%, agricultural newborn 500#2%, thiophene ketone 2.5%, N, dinethylformamide 45%, surplus supplies 100% with absolute ethyl alcohol.
The compounded cream agent of embodiment 11 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 1%, and kasugarnycin 4%, emulsifier 0,203 15%, organosilicon bleeding agent (the ethyoxyl modification gathers trisiloxanes) 3%, N, dinethylformamide 55%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 12 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 4%, and kasugarnycin 1%, emulsifier 0,203 12%, bleeding agent OT-99 10%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 13 Ostholes and kasugarnycin
Process for preparation is with embodiment 6, and different is, Osthole 6%, and kasugarnycin 2%, emulsifier 0,203 10%, agricultural newborn 500#3%, bleeding agent OT-99 15%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 14 Ostholes and streptomycin sulphate
The compounded cream agent of Osthole and streptomycin sulphate contains Osthole 2%, streptomycin sulphate 16%, and emulsifier 0,203 5%, bleeding agent OT-99 8%, N, dinethylformamide 55%, surplus supplies 100% with methyl alcohol.
Process for preparation:
By prescription various active substance Ostholes and streptomycin sulphate are accurately taken by weighing out earlier, accurately take by weighing emulsifier, bleeding agent, N, dinethylformamide more respectively.
Earlier use N, dinethylformamide fully dissolves streptomycin sulphate, adds Osthole again in jar, is stirred to Osthole and dissolves fully.The 3rd step added bleeding agent and emulsifier in jar, lasting stir about time more than 1 hour, supply with methyl alcohol again.Continue to stir again more than 1 hour till the missible oil homogeneous transparent.
Take out semi-finished product and measure effective component content, and the every staple product quality control index of missible oil, the qualified product that then is packaged into.
The compounded cream agent of embodiment 15 Ostholes and streptomycin sulphate
Process for preparation is with embodiment 14, and different is, Osthole 3%, and streptomycin sulphate 6%, emulsifier 0,203 20%, bleeding agent OT-99 8%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 16 Ostholes and streptomycin sulphate
Process for preparation is with embodiment 14, and different is, Osthole 4%, and streptomycin sulphate 2%, emulsifier 0,203 16%, bleeding agent thiophene ketone 4%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 17 Ostholes and streptomycin sulphate
Process for preparation is with embodiment 14, and different is, Osthole 4%, and streptomycin sulphate 4%, emulsifier 0,203 18%, bleeding agent thiophene ketone 6%, N, dinethylformamide 50%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 18 Ostholes and streptomycin sulphate
Process for preparation is with embodiment 14, and different is, Osthole 2%, and streptomycin sulphate 8%, emulsifier 0,203 12%, agricultural newborn 500#5%, organosilicon bleeding agent 1%, N, dinethylformamide 55%, surplus supplies 100% with methyl alcohol.
The compounded cream agent of embodiment 19 Ostholes and streptomycin sulphate
Process for preparation is with embodiment 14, and different is, Osthole 1%, and streptomycin sulphate 6%, emulsifier 0,203 16%, organosilicon bleeding agent (the ethyoxyl modification gathers trisiloxanes) 10%, N, dinethylformamide 45%, surplus supplies 100% with methyl alcohol.
Experimental example 1 Osthole and jinggangmeisu composite dose
Osthole and jinggangmeisu all have the activity of good restraining Rhizoctonia solani Kuhn, when with the two with proper proportion composite the time because synergy mutually, bacteriostatic activity is stronger.The proportion of Osthole and composite jinggangmycin is that 1～6 part of Osthole (folding hundred) is mixed with 1 part of jinggangmeisu (calculating with A component folding hundred), and its co-toxicity coefficient value is 308～633.In the various composite proportionings with Osthole: jinggangmeisu=6: 1 is best, and secondly be Osthole: jinggangmeisu=4: 1, synergy also clearly see Table 1.Each data all is the mean value of three repetitions in the table 1, and co-toxicity coefficient calculates by the Sun-Johnson method.
Table 1 Osthole and jinggangmeisu are to the joint toxicity measuring result of Rhizoctonia solani Kuhn
What * cultivate the employing of rice sheath blight disease pathogen in this test is potato sucrose yeast extract agar medium.
Conclusion: from the measurement result of table 1 as can be seen, Osthole and composite jinggangmycin have clearly synergistic effect to Rhizoctonia solani Kuhn, and particularly 6 parts of Ostholes add composite dose of 1 part of jinggangmeisu, and its virulence can improve more than 5 times.Not only co-toxicity coefficient is higher for 6: 1,4: 1 two kinds of compounded combination, and EC
50, EC
95Be worth all lowlyer, have to be applied to produce actual possibility.
Composite dose of pot experiment of preparing and preventing and treating rice sheath blight disease of experimental example 2 Ostholes and jinggangmeisu
Use earlier N, dinethylformamide dissolves Osthole and the former medicine of jinggangmeisu, is made into Osthole respectively: jinggangmeisu is the preparation of 4: 1 and 6: 1 two proportionings.Contain surfactant 0,203 12% in the preparation, bleeding agent OT-99 (Jiangsu Tianyin chemical Co., Ltd) 10%, the effective ingredient total content is 3.5% in the preparation.The pot experiment method is by " Plant Pathogen Method " (third endition) FANGZHONG-da[M] the described method of .Beijing:China Agoriculture Press1998 carries out.The agent of jinggangmeisu list is established three kinds of concentration of 40,60,80 (μ g/mL) and is handled, the agent of Osthole list is established three kinds of concentration of 20,40,80 (μ g/mL) and is handled, two kinds of mixtures are all established three kinds of concentration of 20,40,80 (μ g/mL) and are handled, with clear water as blank, 4 repetitions are established in totally 13 processing, every processing.Inoculate the strong Rhizoctonia solani Kuhn bacterium piece of dip-dye power behind the spray medicine, 5 in every basin is preserved moisture at once.To the paddy rice heading, investigate result of the test, see Table 2.
Table 2 Osthole and composite jinggangmycin agent prevent and treat the results from pot experiment test of rice sheath blight disease
Osthole and jinggangmeisu 6: 1 and 4: 1 two kinds of compounded cream preparations use the concentration of 20 μ g/mL, can reach 78.72% and 71.42% respectively to the control efficiency of rice sheath blight disease, near the level of jinggangmeisu list agent 80 μ g/mL.The prescription synergistic effect of these two kinds of composite preparations is obvious, can reduce dosage.
Composite dose of effect of preventing and treating wheat scab of experimental example 3 Ostholes and jinggangmeisu
Table 3 is listed is with Osthole and the composite jinggangmycin joint toxicity measuring result to wheat scab.Each proportioning is established 6 concentration, and each concentration repeats for 3 times, and fusarium graminearum is carried out indoor biological activity determination.The 5 kinds of compound proportions of surveying except that Osthole: jinggangmeisu be synergistic effect in 1: 2 not obvious, all the other 4 kinds of proportionings all show as synergistic effect.
Table 3 Osthole and composite jinggangmycin are to the joint toxicity measuring result of wheat scab
Osthole that application experiment example 2 is formulated and jinggangmeisu composite dose (i.e. composite dose 1 in the table 2 and composite dose 2) carries out wheat scab control test in the Ezhou, Hubei Province, the results are shown in Table 4.
Composite dose of field test results of preventing and treating wheat scab of table 4 3.5% Osthole and jinggangmeisu
Conclusion: it is relatively poor that the agent of jinggangmeisu list prevents and treats the effect of wheat scab, and it is also undesirable that the agent of Osthole list prevents and treats the effect of wheat scab.But after the two is composite, can play synergistic effect, the control efficiency of complex preparation 1 and complex preparation 2 has all reached more than 85%, and is suitable with contrast medicament carbendazim.
The composition of experimental example 4 Ostholes and kasugarnycin
It is composite that the Osthole (contain 92%) of employing through purifying and the former medicine of 65% kasugarnycin (Ai Nuo Co., Ltd of North China pharmacy group) carry out, and at its co-toxicity of indoor measurement, the results are shown in Table 5.
Table 5 Osthole and kasugarnycin are to the joint toxicity measuring result of rice blast
Conclusion: find that after tested the various proportionings of trying all have synergistic effect, wherein Osthole: the co-toxicity coefficient of kasugarnycin=4: 1 reaches 564, and kasugarnycin is having very strong synergistic effect to Osthole aspect the inhibition Pyricularia oryzae.
Composite dose of preparation of experimental example 5 Ostholes and kasugarnycin and the effect of preventing and treating rice blast
Use N, dinethylformamide dissolving Osthole and the former medicine of kasugarnycin (production of Ai Nuo company of North China pharmacy group) and add 10% 0203 emulsifier, 4% agricultural newborn 500# and 3% organosilicon bleeding agent.Manufacture experimently out three kinds of Osthole kasugarnycin missible oil that proportioning is different altogether, its content is that the ratio of Osthole and kasugarnycin is respectively in 3.5%, three kind of different missible oil: 2: 1 (being to contain Osthole 2.33% in the missible oil, kasugarnycin 1.17%); 4: 1 (being to contain Osthole 2.8% in the missible oil, kasugarnycin 0.7%); With 1: 2 (being to contain Osthole 1.17% in the missible oil, kasugarnycin 2.33%).Carry out rice blast (the ear stem pest are main) control test with this three kinds composite dose in Lichuan county, Enshi, Hubei Province, the results are shown in Table 6.
The field test effect of table 6 3.5% Osthole kasugarnycin compounded cream control rice blast
Conclusion: three kinds composite dose control efficiency is all good than single agent, and particularly 4: 1 composite dose of preventive effect can reach 92.69%, and dosage significantly descends.
The composition of experimental example 6 Ostholes and streptomycin sulphate
It is composite that the Osthole (contain 92%) of employing through purifying and 40% streptomycin sulphate soluble powder (Ai Nuo Co., Ltd of North China pharmacy group) carry out, and each proportioning preparation is obvious to the rice sheath blight disease synergistic effect under the cited ratio in table 7.
Table 7 Osthole and streptomycin sulphate are to the joint toxicity measuring result of rice sheath blight disease
What * cultivate the employing of rice sheath blight disease pathogen in this test is the potato glucose agar medium.
Conclusion: streptomycin sulphate itself is very weak to the bacteriostatic activity of rice sheath blight disease, but after it and fructus cnidii complex, can play obvious synergistic effect, its co-toxicity coefficient of complex preparation (CTC) of the 5 kinds of different compound proportions that try is all more than 307.40, and synergistic effect is obvious.
The preparation that experimental example 7 Ostholes and streptomycin sulphate are composite dose and prevent and treat the effect of rice sheath blight disease
Use N, dinethylformamide dissolving Osthole and streptomycin sulphate, the missible oil of two kinds of different proportionings of preparation, proportioning 1 is an Osthole: streptomycin sulphate=2: 1 (effective ingredients, W/W), promptly in the 830ml solvent, add 30 gram Ostholes, 15 gram streptomycin sulphates (pure), other adds 105 gram emulsifier 0203, organosilicon bleeding agent 20 grams, (less than is then used the methyl alcohol polishing for 1 liter, down together) is mixed into 1 liter of missible oil; Proportioning 2 is an Osthole: and streptomycin sulphate=1: 2 (effective ingredient W/W), promptly adds 15 gram Ostholes in the 820ml solvent, 30 gram streptomycin sulphates (pure), and other adds 105 gram emulsifier 0203, and organosilicon bleeding agent 30 grams are mixed into 1 liter of missible oil.The content of two kinds of missible oil is 4.5%, prevents and treats the test of rice sheath blight disease with these two kinds of missible oil in five li boundary's paddy fields of Wuhan City, Hubei Province Jiangxia District, the results are shown in Table 8.
Table 8 Osthole and streptomycin sulphate are prevented and treated the rice sheath blight disease field test effect for two kinds composite dose
Conclusion: the agent of streptomycin sulphate list prevents and treats the rice sheath blight disease weak effect, the effect of pure osthole for preventing and treating rice sheath blight disease is also undesirable, and the preventive effect of jinggangmeisu 100 μ g/mL can reach 82.35%, the complex preparation 90 μ g/mL of Osthole and two kinds of different proportions of streptomycin are suitable, and preventive effect reaches 80.11-86.24%.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (7)
1. composite dose of Osthole and farm antibiotics, it is characterized in that it comprises effective component of osthole and farm antibiotics, the weight ratio of the two is 1～6: 1～8; Described antibiotic is jinggangmeisu, kasugarnycin or agricultural streptomycin.
2. Osthole according to claim 1 and farm antibiotics composite dose is characterized in that the weight ratio of Osthole and farm antibiotics is 1～4: 1～6.
3. Osthole according to claim 1 and farm antibiotics composite dose is characterized in that when Osthole and composite jinggangmycin, the proportioning between Osthole and the jinggangmeisu is 1～6: 1.
4. Osthole according to claim 1 and 2 and farm antibiotics composite dose is characterized in that, when Osthole and kasugarnycin were composite, the proportioning between Osthole and the kasugarnycin was 1～4: 1～4.
5. Osthole according to claim 1 and 2 and farm antibiotics composite dose is characterized in that, when Osthole and agricultural streptomycin were composite, the proportioning between Osthole and the agricultural streptomycin was 1～2: 1～8.
6. according to composite dose of any described Osthole of claim 1-5 and farm antibiotics, it is characterized in that it comprises following composition and content:
Active ingredient: 2-18%,
Emulsifier: 5-25%,
Bleeding agent: 1-15%,
Solvent: 40-92%,
Emulsifier is farming breast 0203 or agricultural newborn 500#, and bleeding agent is bleeding agent OT-99, thiophene ketone or organosilicon bleeding agent; Solvent is N-N, dimethyl formamide, absolute ethyl alcohol or methyl alcohol.
7. composite dose of any described Osthole of claim 1-6 and farm antibiotics application in preparation control and treatment rice sheath blight disease, wheat scab or rice blast agricultural chemicals.
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| CN102293205A (en) * | 2011-05-27 | 2011-12-28 | 江苏省绿盾植保农药实验有限公司 | Osthole and ningnanmycin compound bactericide |
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| CN102293205A (en) * | 2011-05-27 | 2011-12-28 | 江苏省绿盾植保农药实验有限公司 | Osthole and ningnanmycin compound bactericide |
| CN103004802A (en) * | 2013-01-15 | 2013-04-03 | 福建凯立生物制品有限公司 | Biological fungicide composition and application thereof |
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