CN101343315B - 截短的人***瘤病毒6型l1蛋白 - Google Patents
截短的人***瘤病毒6型l1蛋白 Download PDFInfo
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- CN101343315B CN101343315B CN2008101113904A CN200810111390A CN101343315B CN 101343315 B CN101343315 B CN 101343315B CN 2008101113904 A CN2008101113904 A CN 2008101113904A CN 200810111390 A CN200810111390 A CN 200810111390A CN 101343315 B CN101343315 B CN 101343315B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C12P21/00—Preparation of peptides or proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2796/00—Viruses not covered by groups C12N2710/00 - C12N2795/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/01—DNA viruses
- G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Na2HPO4 | 6g |
KH2PO4 | 3g |
NaCl | 0.5g |
NH4Cl | 1g |
酪蛋白水解物 | 20g |
MgCl2 | 0.095g |
Claims (19)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2008101113904A CN101343315B (zh) | 2007-05-29 | 2008-05-29 | 截短的人***瘤病毒6型l1蛋白 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200710105764 | 2007-05-29 | ||
CN200710105764.7 | 2007-05-29 | ||
CN2008101113904A CN101343315B (zh) | 2007-05-29 | 2008-05-29 | 截短的人***瘤病毒6型l1蛋白 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101343315A CN101343315A (zh) | 2009-01-14 |
CN101343315B true CN101343315B (zh) | 2012-06-13 |
Family
ID=40074567
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2008101113904A Active CN101343315B (zh) | 2007-05-29 | 2008-05-29 | 截短的人***瘤病毒6型l1蛋白 |
Country Status (7)
Country | Link |
---|---|
US (2) | US8748127B2 (zh) |
EP (1) | EP2154149B1 (zh) |
CN (1) | CN101343315B (zh) |
BR (1) | BRPI0810951B8 (zh) |
DK (1) | DK2154149T3 (zh) |
HK (1) | HK1124343A1 (zh) |
WO (1) | WO2008145021A1 (zh) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IN2013CN00536A (zh) | 2010-07-02 | 2015-07-03 | Univ Xiamen | |
CN102229660B (zh) * | 2011-05-25 | 2015-04-22 | 厦门大学 | 截短的人***瘤病毒33型l1蛋白 |
CN105002190B (zh) * | 2013-12-03 | 2022-11-08 | 北京康乐卫士生物技术股份有限公司 | 11型重组人***瘤病毒病毒样颗粒及其制备方法 |
AU2016342376A1 (en) * | 2015-10-22 | 2018-06-07 | Modernatx, Inc. | Sexually transmitted disease vaccines |
CN106831960B (zh) * | 2015-12-04 | 2019-11-05 | 厦门大学 | 一种人***瘤病毒6型l1蛋白的突变体 |
KR20180084139A (ko) * | 2015-12-04 | 2018-07-24 | 시아먼 유니버시티 | 11형 인유두종 바이러스 엘1 단백질의 돌연변이체 |
WO2019233412A1 (zh) * | 2018-06-04 | 2019-12-12 | 厦门大学 | 一种人***瘤病毒18型l1蛋白的突变体 |
CN114539364B (zh) * | 2020-11-26 | 2023-10-20 | 中国医学科学院基础医学研究所 | 一种c端改造的人***瘤病毒6型l1蛋白及其用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000054730A2 (en) * | 1999-03-18 | 2000-09-21 | The President & Fellows Of Harvard College | Compositions preparations and uses of human papillomavirus l1 protein |
WO2003078455A2 (en) * | 2002-03-18 | 2003-09-25 | Glaxosmithkline Biologicals Sa | Virus like particle from papillomavirus and their use in vaccine |
CN1478790A (zh) * | 2002-08-30 | 2004-03-03 | 马润林 | ***瘤病毒衣壳蛋白的原核制备和应用 |
CN101153280A (zh) * | 2006-09-29 | 2008-04-02 | 厦门大学 | 从原核生物中纯化人***瘤病毒晚期蛋白l1的方法 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3110561A1 (de) * | 1981-03-18 | 1982-11-04 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Chemorekrutine der leukozyten und des entszuendungsgewebes: eine neue klasse natuerlicher leukopoetine zurselektiven chemorekrutierung von leukozyten aus dem knochenmark in den blutstrom (leukozytose- und linskverschiebungsreaktion) |
FR2672895B1 (fr) * | 1991-02-15 | 1995-05-12 | Transgene Sa | Procede de purification d'une proteine fortement glycosylee. |
DE69435331D1 (de) * | 1993-03-09 | 2011-02-03 | Univ Rochester | Herstellung von menschlichen papillomavirus HBV-11 Kapsidprotein L1 und Virus-ähnliche Partikeln |
AUPM566794A0 (en) * | 1994-05-17 | 1994-06-09 | University Of Queensland, The | Process and product |
IL113817A (en) * | 1994-06-30 | 2001-03-19 | Merck & Co Inc | Polynucleotide for vaccination against the umbilical cord virus |
US6066324A (en) * | 1994-10-07 | 2000-05-23 | Loyola University Of Chicago | Carboxyl terminal of papilloma virus L1 region is not required for formation of virus-like particles |
US7351533B2 (en) * | 1997-09-05 | 2008-04-01 | Medimmune, Inc. | In vitro method for disassmbly/reassembly of papillomavirus virus-like particles (VLPs). Homogeneous VLP and cavsomere compositions produced by said methods: use thereof as vehicle for improved purification, and delivery of active agents |
US6228368B1 (en) * | 1997-10-06 | 2001-05-08 | Loyola University Of Chicago | Papilloma virus capsomere formulations and method of use |
US7182947B2 (en) | 1998-02-20 | 2007-02-27 | Medigene Ag | Papillomavirus truncated L1 protein and fusion protein constructs |
US20020193565A1 (en) * | 1998-03-27 | 2002-12-19 | Stanley Margaret Anne | Antigen preparation and use |
ES2262333T3 (es) * | 1998-08-14 | 2006-11-16 | MERCK & CO., INC. | Procedimiento para purificar particulas similares a virus de papilomavirus humano. |
GB0206360D0 (en) * | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
MY139500A (en) * | 2003-11-12 | 2009-10-30 | Merck Sharp & Dohme | Optimized expression of hpv 58 l1 in yeast |
GB0624227D0 (en) * | 2006-12-05 | 2007-01-10 | Common Services Agency | Protein purification |
EP2129394B1 (en) * | 2007-03-09 | 2012-06-20 | Merck Sharp & Dohme Corp. | Papillomavirus vaccine compositions |
BRPI0811016B1 (pt) * | 2007-04-29 | 2021-09-21 | Xiamen Innovax Biotech Co., Ltd. | Proteína li truncada do papiloma vírus humano tipo 16 |
DK2147926T3 (en) | 2007-04-29 | 2016-11-28 | Beijing Wantai Biological Pharmacy Entpr Co Ltd | Truncated human papillomavirus type 18 L1 protein |
US9533035B2 (en) * | 2007-05-29 | 2017-01-03 | Xiamen University | Truncated L1 protein of human papillomavirus type 11 |
-
2008
- 2008-05-29 CN CN2008101113904A patent/CN101343315B/zh active Active
- 2008-05-29 EP EP08757381.2A patent/EP2154149B1/en active Active
- 2008-05-29 BR BRPI0810951A patent/BRPI0810951B8/pt active IP Right Grant
- 2008-05-29 US US12/601,972 patent/US8748127B2/en active Active
- 2008-05-29 DK DK08757381.2T patent/DK2154149T3/da active
- 2008-05-29 WO PCT/CN2008/001050 patent/WO2008145021A1/zh active Application Filing
-
2009
- 2009-03-03 HK HK09102006.9A patent/HK1124343A1/xx unknown
-
2014
- 2014-04-08 US US14/248,063 patent/US9745351B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000054730A2 (en) * | 1999-03-18 | 2000-09-21 | The President & Fellows Of Harvard College | Compositions preparations and uses of human papillomavirus l1 protein |
WO2003078455A2 (en) * | 2002-03-18 | 2003-09-25 | Glaxosmithkline Biologicals Sa | Virus like particle from papillomavirus and their use in vaccine |
CN1478790A (zh) * | 2002-08-30 | 2004-03-03 | 马润林 | ***瘤病毒衣壳蛋白的原核制备和应用 |
CN101153280A (zh) * | 2006-09-29 | 2008-04-02 | 厦门大学 | 从原核生物中纯化人***瘤病毒晚期蛋白l1的方法 |
Non-Patent Citations (1)
Title |
---|
W.Caparros-Wanderley et al.Intratype sequence variation among clinical isolates of the human papillomavirus type 6 L1 ORF:clustering of mutations and identification of a frequent amino acid sequence variant.《Journal of General Virology》.1999,第80卷1025-1033. * |
Also Published As
Publication number | Publication date |
---|---|
WO2008145021A1 (en) | 2008-12-04 |
BRPI0810951A2 (pt) | 2015-07-21 |
HK1124343A1 (en) | 2009-07-10 |
BRPI0810951B1 (pt) | 2020-10-06 |
US9745351B2 (en) | 2017-08-29 |
EP2154149A1 (en) | 2010-02-17 |
EP2154149A4 (en) | 2011-04-06 |
US8748127B2 (en) | 2014-06-10 |
DK2154149T3 (da) | 2019-10-14 |
BRPI0810951B8 (pt) | 2021-05-25 |
US20100255021A1 (en) | 2010-10-07 |
EP2154149B1 (en) | 2019-07-10 |
CN101343315A (zh) | 2009-01-14 |
US20140288283A1 (en) | 2014-09-25 |
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Effective date of registration: 20190724 Address after: Siming District of Xiamen city in Fujian Province, 361005 South Siming Road No. 422 Co-patentee after: Xiamen Innovax Biotech Co., Ltd. Patentee after: Xiamen University Address before: Siming District of Xiamen city in Fujian Province, 361005 South Siming Road No. 422 Co-patentee before: Beijing Wantai Biological Pharmacy Enterprise Co., Ltd. Patentee before: Xiamen University |