Preparation method and products thereof with Chinese medicine extraction liquid of balance adjustment skin oil and fat
Technical field
The present invention relates to preparation method of a kind of Chinese medicine extraction liquid with balance adjustment skin oil and fat and products thereof, effective ingredient is a Chinese medicine Rhizoma Polygoni Cuspidati extracting solution, can be used for the cosmetics or the medicine of balance adjustment skin oil and fat and skin nursing.
Background technology
Skin oil and fat has skin to be preserved moisture, moistens and the barrier protection effect, but hypersteatosis not only influences outward appearance, also can block pore, causes skin problems such as seborrheic dermatitis and acne.Under the normal condition, human body has the homeostasis regulating action to sebaceous secretion.As: relatively drying or skin are when sebum is lost in a large number under the effect of strong defat detergent when external environment, and sebaceous gland can spontaneous increase sebum secretion amount compensate; When skin oil and fat was many, the sebum amount of smegma will reduce.When this self regulation effect was lost efficacy, hypersteatosis or very few situation will take place, it is excessively greasy or over-drying to show as skin, promptly common alleged dry skin and oily skin.
At present in China the Hans, simple oily skin or simple dry skin are actually rare, most people show as mixed type skin, promptly show as oily skin at some position of face (as: trigonum, forehead), and in the more dry skin that shows as of buccal portion.This has brought bigger difficulty to selecting for use of cosmetics.Because consumer is difficult to the facial skin of different parts is selected for use two kinds of products that effect is opposite.
Mainly use astringent or simple oils and fats inhibitor for oily skin in the cosmetics at present, mainly adopt for dry skin and replenish greasy method, these two kinds of methods all can't solve the problem of mixed type skin.
Balance adjustment is one of basic theories of Chinese medicine, we find under study for action, the medicinal herb components that has can be rebuild the self-regulating function that human body lost efficacy, make skin recover balance adjustment function again to skin oil and fat, balance adjustment effect by this oneself, when skin is in different conditions following time, sebaceous gland will be adjusted the sebaceous secretion amount, makes it reach normal state.This composition is joined in cosmetics or the medicine for external use, just can handle the skin of different sebum secretion states with a kind of product.And, adopt the cosmetics life-time service of this composition can not have safety preferably because of untoward reaction takes place overaction.
The Chinese medicine Rhizoma Polygoni Cuspidati is polygonaceae plant Rhizoma Polygoni Cuspidati Polygonum cuspidatum Sieb.et Zucc. rhizome and root.Introducing in the Ancient Times in China medical book " Bencao Tujing " with it transfers the strong tea external application can control dermatosiss such as carbuncle pain.We find that through preliminary study secretion has amphicheirality's regulating action to some composition that extracts to skin oil and fat, is the oil-control secretion for greasy cutaneous manifestations, then shows as the promotion sebum secretion for the insufficient skin of fat secretion from Rhizoma Polygoni Cuspidati.The effect of relevant this respect, up to now, Shang Weijian has the people to report.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of preparation method with Chinese medicine extraction liquid of balance adjustment skin oil and fat, the especially extracting method of Chinese medicine Rhizoma Polygoni Cuspidati extracting solution.
Another technical problem to be solved by this invention is to provide a kind of Chinese medicine extraction liquid product at above-mentioned preparation method, and is effective to balance skin secretion oils and fats.
A technical scheme more to be solved by this invention is to provide a kind of purposes in skin oil and fat adjusting and skin nursing products at the said goods.
The present invention solves the problems of the technologies described above the technical scheme of being taked: a kind of preparation method with Chinese medicine extraction liquid of balance adjustment skin oil and fat, and described Chinese medicine extraction liquid is the Rhizoma Polygoni Cuspidati extracting solution, extracting method comprises the steps: in regular turn
The first step: under 30~80 ℃, the alcohol solution dipping with 60~90% 1~3 hour repeats above-mentioned immersion 1~3 time with the Chinese medicine Rhizoma Polygoni Cuspidati, gets soak;
Second step: merge soak, filter, filtrate is concentrated into 1/5~1/7 of former weight;
The 3rd step: filtrate is adsorbed by adsorption column, and adsorption column washes with water to colourless, is eluted to colourless with 8~15% alcoholic solution again; With 60~90% alcoholic solution eluting, consumption is the volume of 3~4 adsorption columns then, will merge with the eluent of 60~90% alcoholic solution eluting, and being concentrated into density is 1.15~1.20;
The 4th step: concentrated solution dilutes with the mixed liquor of dipropylene glycol and water, obtains the Rhizoma Polygoni Cuspidati extracting solution, and the weight ratio of mixed liquor and concentrated solution is 1: 10~1: 15.
Concrete, in the first step, temperature can be 30,35,40,45,50,55,60,65,70 or 80 ℃; The weight concentration of 60~90% alcoholic solution can be 60,65,70,75,80,85 or 90%; Soak time 1,1.5,2,2.5 or 3 hours;
In second step, filtrate is concentrated into 1/5,1/5.5,1/6,1/6.5 or 1/7 of former weight;
In the 3rd step, the weight concentration of 8~15% alcoholic solution can be 8,9,10,11,12,13,14 or 15%; The weight concentration of 60~90% alcoholic solution can be 60,65,70,75,80,85 or 90%; 60~90% alcoholic solution eluting consumptions can be 3,3.2,3.5,3.8 or 4 adsorption column volumes; Concentrate the density that reaches and to be 1.15,1.16,1.17,1.18,1.19 or 1.20;
In the 4th step, the mixed liquor of dipropylene glycol and water and the weight ratio of concentrated solution can be 1: 10,1: 10.5, and 1: 11,1: 11.5,1: 12,1: 12.5,1: 13,1: 13.5,1: 14,1: 14.5 or 1: 15.
On the basis of such scheme, in the first step, the weight ratio of Rhizoma Polygoni Cuspidati and alcoholic solution is 1: 10~1: 30.
Concrete, the weight ratio of Rhizoma Polygoni Cuspidati and alcoholic solution can be 1: 10,1: 12, and 1: 14,1: 15,1: 16,1: 18,1: 20,1: 22,1: 24,1: 25,1: 26,1: 28 or 1: 30.
Further preferred, in the first step, the Chinese medicine Rhizoma Polygoni Cuspidati is under 47~75 ℃, and the alcohol solution dipping with 70~80% 1.5~2.5 hours repeats above-mentioned immersion 1~3 time, and the weight ratio of Rhizoma Polygoni Cuspidati and alcoholic solution is 1: 15~1: 25, gets soak.
On the basis of such scheme, in second step, merge soak, filter, filtrate is concentrated into 1/5.5~1/6.6 of former weight.
On the basis of such scheme, in the 3rd step, described adsorption column is the D101 resin column.
On the basis of such scheme, in the 4th step, dipropylene glycol is 5: 1~1: 5 with the mixed weight ratio of water.
Concrete, dipropylene glycol can be 5: 1 with the mixed weight ratio of water, 4.5: 1, and 4: 1,3.5: 1,3: 1,2.5: 1,2: 1,1.5: 1,1: 1,1: 1.5,1: 2,1: 2.5,1: 3,1: 3.5,1: 4,1: 4.5,1: 5.
In the 4th step, the mixed liquor of dipropylene glycol and water and the weight ratio of concentrated solution be preferably 1: 12~and 1: 14, dipropylene glycol is preferably 4: 1 with the mixed weight ratio of water~and 1: 4.
At the product of above-mentioned preparation method acquisition, for having the Rhizoma Polygoni Cuspidati extracting solution of balance adjustment skin oil and fat.
At the purposes of above-mentioned Rhizoma Polygoni Cuspidati extracting solution, be used for preparing a kind of of cosmetics or skin treating external-application cream, emulsion, astringent, Cosmetic pack.Specifically be that the substrate of Rhizoma Polygoni Cuspidati extracting solution and known cosmetics and medicine or adjuvant, carrier, additive are mixed mutually, be prepared according to the method for routine.
The invention has the beneficial effects as follows:
Adopt the Rhizoma Polygoni Cuspidati extracting solution of extracting method preparation of the present invention to add in cosmetics cream, emulsion, astringent, facial film and the topical drug, can produce the effect that the amphicheirality regulates to the skin oil and fat secretion, when the skin oil and fat supersecretion, its secretion is reduced; When the skin oil and fat hyposecretion, its secretion is increased.
The specific embodiment
Embodiment 1
A kind of preparation method with Chinese medicine extraction liquid of balance adjustment skin oil and fat, described Chinese medicine extraction liquid is the Rhizoma Polygoni Cuspidati extracting solution, extracting method comprises the steps: in regular turn
The first step: with the Chinese medicine Rhizoma Polygoni Cuspidati under 75 ℃, the alcohol solution dipping with 80% 2.5 hours, alcoholic solution 1000g, Rhizoma Polygoni Cuspidati 50g repeats above-mentioned immersion 2 times, soak;
Second step: merge soak, filter, filtrate is concentrated into 1/6 of former weight;
The 3rd step: filtrate is by the absorption of D101 resin column, and the D101 resin column washes with water to colourless, is eluted to colourless with 12% alcoholic solution again; With 85% alcoholic solution eluting, consumption is the volume of 3 D101 resin columns then, will merge with the eluent of 85% alcoholic solution eluting, is concentrated into density and is 1.15~1.20 concentrated solution;
The 4th step: concentrated solution dilutes with the mixed liquor of 1: 1 dipropylene glycol of weight ratio and water, and the weight ratio of mixed liquor and concentrated solution is 1: 14, obtains the Rhizoma Polygoni Cuspidati extracting solution.
Embodiment 2
A kind of preparation method with Chinese medicine extraction liquid of balance adjustment skin oil and fat, described Chinese medicine extraction liquid is the Rhizoma Polygoni Cuspidati extracting solution, extracting method comprises the steps: in regular turn
The first step: with the Chinese medicine Rhizoma Polygoni Cuspidati under 70 ℃, the alcohol solution dipping with 75% 2 hours, alcoholic solution 1000g, Rhizoma Polygoni Cuspidati 40g repeats above-mentioned immersion 2 times, soak;
Second step: merge soak, filter, filtrate is concentrated into 1/5 of former weight;
The 3rd step: filtrate is adsorbed by the D101 resin column, the D101 resin column washes with water to colourless, be eluted to colourless with 10% alcoholic solution again, then with 90% alcoholic solution eluting, consumption is the volume of 4 D101 resin columns, to merge with the eluent of 90% alcoholic solution eluting, be concentrated into density and be 1.15~1.20 concentrated solution;
The 4th step: concentrated solution dilutes with the mixed liquor of 1.5: 1 dipropylene glycol of weight ratio and water, and the weight ratio of mixed liquor and concentrated solution is 1: 13, obtains the Rhizoma Polygoni Cuspidati extracting solution.
Application examples 1
The preparation facial treatment milk comprises following component by weight:
Rhizoma Polygoni Cuspidati extract 1-5%
Stearic acid 1-3%
Hexadecanol 2-4%
Vaseline 2-4%
Lanonol 1-3%
White oil 3-5%
Polyoxyethylene monooleate (10E.O.) 1-3%
Glycerol 3-7%
1,3 butylene glycol 2-5%
Essence is an amount of
Antiseptic is an amount of
Antioxidant is an amount of
Deionized water is added to 100%
The kind of antiseptic described in the prescription and antioxidant and consumption are that present technique field personnel know altogether, preferably 0.1-1 propylparaben/butoben (1: 1-2: 1) and 2,6-di-tert-butyl-4-methy phenol 0.05-0.2%.
(China Light Industry Press publishes according to " cosmetic technology "; Herba Kalimeridis etc. are write, version in 1993), the common process of described facial treatment milk is according to above-listed formulation facial treatment milk of the present invention.
Application examples 2
The preparation protective skin cream comprises following component by weight:
Rhizoma Polygoni Cuspidati extract 1-5%
Stearic acid 1-3%
Hydrogenated lanolin 1-3%
Octadecanol 5-8%
Squalane 4-7%
Octyl dodecanol 5-8%
Polyoxyethylene hexadecanol ether (25E.O.) 2-4%
Lipophile tristerin 1-3%
Glycerol 3-7%
1,3 butylene glycol 2-5%
Essence is an amount of
Antiseptic is an amount of
Antioxidant is an amount of
Deionized water is added to 100%
Identical in the prescription in the definition of antiseptic and antioxidant and the application examples 1.
(China Light Industry Press publishes according to " cosmetic technology "; Herba Kalimeridis etc. are write, version in 1993), the common process of described protective skin cream is according to above-listed formulation protective skin cream of the present invention.
Application examples 3
The preparation astringent comprises following component by weight
Rhizoma Polygoni Cuspidati extract 1-5%
Glycerol 2-4%
Sorbitol (70%) 1-3%
Citric acid 0.1-1%
Polyoxyethylene monooleate (20E.O.) 1-3%
Ethanol 10-15%
Essence is an amount of
Antiseptic is an amount of
Deionized water is added to 100%
Identical in the prescription in the definition of antiseptic and the application examples 1.
(China Light Industry Press publishes according to " cosmetic chemistry and Technology complete works "; QiuBing Yi etc. write, version in 1997), the common process of described astringent is according to above-listed formulation astringent of the present invention.
Application examples 4
Preparation Cosmetic pack liquid comprises following component by weight
Rhizoma Polygoni Cuspidati extract 1-5%
Glycerol 2-4%
Sorbitol (70%) 1-3%
Citric acid 0.1-1%
Polyoxyethylene monooleate (20E.O.) 1-3%
Ethanol 10-15%
Carbopol 940 (4%) 5-8%
Essence is an amount of
Antiseptic is an amount of
Deionized water is added to 100%
Pour in the bag that the non-woven fabrics mask is housed with above-mentioned facial mask liquid, every 20-40 gram, heating is sealed.
Identical in the prescription in the definition of antiseptic and the application examples 1.
Experimental example
The object of observation is 7 normal volunteers, 4 of 3 women of male, and the age is in 17-36 year, 26 years old mean age.
Experiment material: the cream that contains 1.5% and 4.0% Rhizoma Polygoni Cuspidati extract.
Experimental apparatus: sebum is measured the Sebumeter skin oil and fat tester that adopts CK company, and the test position is frons and cheek.
Method of testing:
Being the boundary with the place between the eyebrows earlier before the test, is left and right two halves with experimenter's forehead portion, measures the skin oil and fat of left and right forehead and both sides cheek portion earlier.The record determination data.
Adopt double-blind method to give the cream that the experimenter contains 1.5% and 4.0% Rhizoma Polygoni Cuspidati extract then, a kind of cream is used on both sides respectively, uses every day 2 times, uses for 4 weeks altogether, and record is once tried position sebum measured value weekly.
Experimental result:
Annotate: left volume, left cheek use the cream that contains 1.5% Rhizoma Polygoni Cuspidati extract; Right volume, right cheek use the cream that contains 4.0% Rhizoma Polygoni Cuspidati extract.
Mean value calculation:
The position |
Before the use |
Use 1 week of back |
Use 2 weeks of back |
Use 3 weeks of back |
Use 4 weeks of back |
Left side volume |
86.42 |
81.00 |
74.14 |
66.71 |
64.42 |
Left side cheek |
38.00 |
41.71 |
44.00 |
48.14 |
49.86 |
Right volume |
85.43 |
80.71 |
73.71 |
66.28 |
62.29 |
Right cheek |
38.29 |
42.00 |
45.71 |
49.29 |
53.29 |
From The above results as can be seen, adopt oils and fats equilibrium modifier of the present invention that the fat secretion at the higher position of fat secretion is reduced, the fat secretion at the position that fat secretion is less increases.