CN101321771A - 青霉素钾盐的制备工艺 - Google Patents
青霉素钾盐的制备工艺 Download PDFInfo
- Publication number
- CN101321771A CN101321771A CNA2006800452303A CN200680045230A CN101321771A CN 101321771 A CN101321771 A CN 101321771A CN A2006800452303 A CNA2006800452303 A CN A2006800452303A CN 200680045230 A CN200680045230 A CN 200680045230A CN 101321771 A CN101321771 A CN 101321771A
- Authority
- CN
- China
- Prior art keywords
- penicillin
- group
- alcohol
- sylvite
- technology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/04—Preparation
- C07D499/14—Preparation of salts
- C07D499/16—Preparation of salts of alkali or alkaline earth metals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
# | 蒸发的体积(ml) | 残余水含量(%) | 加入的甲醇(ml) | 母液体积(ml) | 母液损失(%) | 产率(%) |
1 | 190(16) | nd | 100 | 770 | 1.7 | 96.5 |
2 | 328(16) | nd | 100 | 645 | 1.6 | 96.3 |
3 | 292(13) | 0.04 | 100 | 620 | 1.2 | 98.0 |
4 | 334(18) | 0.04 | 100 | 650 | 1.7 | 97.5 |
5 | 206(19) | 0.18 | 150 | 720 | 2.3 | 94.5 |
Claims (6)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05111630.9 | 2005-12-02 | ||
EP05111630 | 2005-12-02 | ||
EP06110094.7 | 2006-02-17 | ||
EP06110094 | 2006-02-17 | ||
PCT/EP2006/069146 WO2007063107A1 (en) | 2005-12-02 | 2006-11-30 | Process for the preparation of a potassium salt of penicillin |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101321771A true CN101321771A (zh) | 2008-12-10 |
CN101321771B CN101321771B (zh) | 2012-05-30 |
Family
ID=35759172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800452303A Active CN101321771B (zh) | 2005-12-02 | 2006-11-30 | 青霉素钾盐的制备工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101321771B (zh) |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2599401A (en) * | 1947-08-15 | 1952-06-03 | Lilly Co Eli | Process of obtaining crystalline penicillin salts |
PT977883E (pt) * | 1997-04-22 | 2005-01-31 | Dsm Ip Assets Bv | Processo melhorado para a producao fermentativa de penicilina |
CN1055289C (zh) * | 1997-12-31 | 2000-08-09 | 华北制药股份有限公司 | 青霉素钠一次结晶生产方法 |
-
2006
- 2006-11-30 CN CN2006800452303A patent/CN101321771B/zh active Active
Also Published As
Publication number | Publication date |
---|---|
CN101321771B (zh) | 2012-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20090162905A1 (en) | Method for Purification of Hyaluronic Acid Salt | |
KR100293172B1 (ko) | 스트렙토마이세스sp. P6621 FERM P2804의 발효액으로부터 클라불란산과 제약학적으로 허용가능한 이들의 염을 단리하는 신규한 방법 | |
CN101062934B (zh) | 从发酵技术培养物中提取纳他霉素的方法 | |
JPS61119195A (ja) | クラブラン酸の製法 | |
CN104480181A (zh) | 3-去乙酰基-7-氨基头孢烯酸的制备方法 | |
CN109628541A (zh) | 一种酶法合成青霉素v盐的方法 | |
JP4275621B2 (ja) | ユビキノン−10含有溶液の製造方法 | |
EP0977883B1 (en) | Improved process for the fermentative production of penicillin | |
CA2598565C (en) | Purification of mupirocin | |
CN101321771B (zh) | 青霉素钾盐的制备工艺 | |
TW565612B (en) | Improved process for the fermentative production of cephalosporin | |
CN112322688B (zh) | 一种从酶催化合成头孢丙烯生产废液中回收7-apra的方法 | |
JPH07135989A (ja) | 抗生物質の製造方法 | |
JP2873894B2 (ja) | 環状デプシペプチドおよびその製造法 | |
WO2007063107A1 (en) | Process for the preparation of a potassium salt of penicillin | |
CZ307497A3 (cs) | Způsob oddělování ampicilinu | |
CN113005168B (zh) | 一种6-氨基青霉烷酸的制备方法 | |
JPH101496A (ja) | アベルメクチンの精製法 | |
NO880590L (no) | Hoeyere alkylpyrrolidon-ekstraksjonsmidler for vannopploeselige fenoliske eller karbocykliske antibiotika. | |
MX2008007066A (en) | Process for the preparation of a potassium salt of penicillin | |
CN108147976B (zh) | 一种去甲基金霉素的提取方法 | |
JPH0956389A (ja) | アベルメクチンの精製法 | |
JP2693536B2 (ja) | (7R)―シクロペンタ〔d〕ピリミジン誘導体の製造法 | |
JPS6121480B2 (zh) | ||
JPS5898095A (ja) | デマノシノシル−マイシナミシン4の製造法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1126476 Country of ref document: HK |
|
ASS | Succession or assignment of patent right |
Owner name: NETHERLANDS COMPANY OF DSM SINOCHEM PHARMACEUTICAL Free format text: FORMER OWNER: DSM IP ASSETS BV Effective date: 20120330 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20120330 Address after: About Holland Applicant after: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. Address before: Holland Heerlen Applicant before: DSM IP ASSETS B.V. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1126476 Country of ref document: HK |
|
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: About Holland Patentee after: DSM Sinochem Pharmaceuticals Netherlands B.V. Address before: About Holland Patentee before: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. |