CN101289499B - 一种可用作免疫抑制剂的带有-Ile-Sta-Pro-残基片段的环肽及其合成工艺 - Google Patents
一种可用作免疫抑制剂的带有-Ile-Sta-Pro-残基片段的环肽及其合成工艺 Download PDFInfo
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- CN101289499B CN101289499B CN2008100610327A CN200810061032A CN101289499B CN 101289499 B CN101289499 B CN 101289499B CN 2008100610327 A CN2008100610327 A CN 2008100610327A CN 200810061032 A CN200810061032 A CN 200810061032A CN 101289499 B CN101289499 B CN 101289499B
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- cyclic peptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
产物 | 产率(%) | 分子量(Calc/found) | 纯度(%) |
A1HS1 | 63.0 | 953.0/954.0 | 92.9 |
Claims (4)
Priority Applications (1)
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CN2008100610327A CN101289499B (zh) | 2008-05-01 | 2008-05-01 | 一种可用作免疫抑制剂的带有-Ile-Sta-Pro-残基片段的环肽及其合成工艺 |
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CN2008100610327A CN101289499B (zh) | 2008-05-01 | 2008-05-01 | 一种可用作免疫抑制剂的带有-Ile-Sta-Pro-残基片段的环肽及其合成工艺 |
Publications (2)
Publication Number | Publication Date |
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CN101289499A CN101289499A (zh) | 2008-10-22 |
CN101289499B true CN101289499B (zh) | 2010-09-08 |
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CN2008100610327A Active CN101289499B (zh) | 2008-05-01 | 2008-05-01 | 一种可用作免疫抑制剂的带有-Ile-Sta-Pro-残基片段的环肽及其合成工艺 |
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Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107400161B (zh) * | 2017-09-19 | 2020-07-21 | 中国工程物理研究院核物理与化学研究所 | 均环肽Cyclo-[(Asp)5-Gly]的制备方法 |
CN107400162B (zh) * | 2017-09-19 | 2020-07-21 | 中国工程物理研究院核物理与化学研究所 | 均环肽Cyclo-[(Asn)5-Cys]的制备方法 |
CN107474118B (zh) * | 2017-09-19 | 2020-07-28 | 中国工程物理研究院核物理与化学研究所 | 均环肽Cyclo-(Cys)6的制备方法 |
CN107602669B (zh) * | 2017-09-19 | 2021-03-16 | 中国工程物理研究院核物理与化学研究所 | 均环肽Cyclo-(Ala)4的制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1500805A (zh) * | 2002-11-14 | 2004-06-02 | 吉尔生化(上海)有限公司 | 一种制备依非巴特的新工艺 |
CN101161674A (zh) * | 2007-07-13 | 2008-04-16 | 中国科学院昆明植物研究所 | 一种环肽,其制备方法和其应用 |
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2008
- 2008-05-01 CN CN2008100610327A patent/CN101289499B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1500805A (zh) * | 2002-11-14 | 2004-06-02 | 吉尔生化(上海)有限公司 | 一种制备依非巴特的新工艺 |
CN101161674A (zh) * | 2007-07-13 | 2008-04-16 | 中国科学院昆明植物研究所 | 一种环肽,其制备方法和其应用 |
Non-Patent Citations (3)
Title |
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Hu jingdan et al.Design and synthesis of statine-containing BACE inhibitors.Bioorganic Medicinal Chemistry Letters13.2003,134335-4339. * |
Siemion I. Z. et al.Cyclolinopeptides and their analogs-a new family ofpeptideimmunosuppressants affecting the calcineurin system.Archivum Immunologiae et Therapiae Experimentalis47.1999,47143-153. * |
徐仲等.奥曲肽固相合成及环化的研究.哈尔滨工业大学学报40 2.2008,40(2),292-295. * |
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CN101289499A (zh) | 2008-10-22 |
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Date | Code | Title | Description |
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C06 | Publication | ||
PB01 | Publication | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20081022 Assignee: Hangzhou Chuntai Technology Co., Ltd. Assignor: Hangzhou Chinese Peptide Co., Ltd. Contract record no.: 2013330000078 Denomination of invention: Cyclic peptide with -Ile-Sta-Sta-Pro- residue segment and used as immunity inhibitor and synthetic process thereof Granted publication date: 20100908 License type: Exclusive License Record date: 20130419 |
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LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: CHINESE PEPTIDE CO., LTD. Free format text: FORMER NAME: ZHONGTAI BIO-CHEM. CO., LTD., HANGZHOU |
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CP01 | Change in the name or title of a patent holder |
Address after: 310018, No. 12, No. 69, Xiasha economic and Technological Development Zone, Hangzhou, Zhejiang Patentee after: CHINESE PEPTIDE COMPANY Address before: 310018, No. 12, No. 69, Xiasha economic and Technological Development Zone, Hangzhou, Zhejiang Patentee before: Hangzhou Chinese Peptide Co., Ltd. |