CN101259250A - Medicaments assembly for activating blood circulation and removing stasis, softening dry feces and dissipating mass and preparation thereof - Google Patents
Medicaments assembly for activating blood circulation and removing stasis, softening dry feces and dissipating mass and preparation thereof Download PDFInfo
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- CN101259250A CN101259250A CNA2008101037741A CN200810103774A CN101259250A CN 101259250 A CN101259250 A CN 101259250A CN A2008101037741 A CNA2008101037741 A CN A2008101037741A CN 200810103774 A CN200810103774 A CN 200810103774A CN 101259250 A CN101259250 A CN 101259250A
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Abstract
The present invention discloses a medicine combination for promoting blood circulation and removing stasis, softening firmness and dispersing stagnation. The effective components of the medicine combination are extracted from more than ten kinds of medicinal materials of Chinese thorowax root, red peony root, white peony root, milkvetch root, green tangerine peel, bitter orange fruit, salvia, thin evodia leaf and twig, white stiff silkworm, wheat germ, turmeric, myrrh, selfheal, pinellia tuber etc. The specific medicine active components of the present invention have the efficacies of promoting blood circulation and removing stasis, softening firmness and dispersing stagnation, and are used for remedying the lump in breast caused by qi stagnation and blood stasis, the mammary lobular hyperplasia, the ovarian cyst and the hysteromyoma for the patient with the symptoms.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, be specifically related to drug regimen of a kind of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving and preparation method thereof.
Technical background
The cause of disease of cyclomastopathy is still very not clear.At present think relevant with endocrine disturbance and Nervous and Mental Factors more.The lutein secretion reduces, and estrogen increases relatively, the major reason of primary disease.Be mainly the hyperplasia of prostate of matter between mammary gland, hypertrophy can betide around the glandular tube and with the cyst that differs in size and form; Also can occur in the glandular tube and show as the nipple sample hypertrophy of epithelium, the cystic dilatation of companion's latex dust.In addition, the outgrowth type of a kind of lobule essence is still arranged.
In recent years, many scholars think that it also is a key factor that causes cyclomastopathy that prolactin antagonist raises.In addition, there are some researches show that hormone receptor also plays an important role in the pathogenic process of cyclomastopathy.
It is the endocrine hormone disorder which kind of reason causes so actually? it is generally acknowledged that multiple factors such as nerve, immunity and trace element all can cause the unbalance of the various endocrine hormones of body.The neural Nervous and Mental Factors that the external environment condition of people living, work and living condition, inter personal contact, various pressure cause etc. all can make the interior environment of human body change, thereby influence the function of hormonal system, and then make the secretion of a certain or several hormones occur unusual.Such as, under secular nervous anxiety state, opium can increase by tension force, the neurotransmitter environment change, and it is inharmonious that estrogen/dopamine takes place, and then causes the PRL secretion to increase, and may cause or increase the weight of cyclomastopathy.
The traditional Chinese medical science thinks that Liver and kidney two warp and breast relations are the closest, secondly is to dash wantonly two arteries and veins.Stagnation of QI due to depression of the liver, feelings will internal injury have material impact in the pathogenic process of nodules of the breast.Depressed emotion usually, the stagnation of QI do not relax, and QI and blood week loss degree pents up in breast stomach network, and newborn network meridian and vessels obstruction is obstructed, stagnation of QI and blood may bring about pain and cause mastalgia; Liver-QI transversely invading the stomach, dysfunction of the spleen in transportation is given birth in expectorant is turbid, and it is nuclear that qi depression to blood stasis is held the expectorant knot under the arm poly-, follows through staying poly-Ruzhong, so the Ruzhong caking.Deficiency of the liver and kindey, Chong and Ren channel disorder also are the major reasons that causes nodules of the breast.Kidney is a source of vital essence of five ZANG-organs, and kidney qiization is given birth to menses, and menses excites to dash appoints, dash and appoint the following uterus of ing, on connect breast, towards times QI and blood, last behavior breast, following behavior warp.If deficiency of kidney-QI, Chong and Ren channel disorder, QI and blood stagnates, and the long-pending stasis of blood is gathered in breast, uterus, or mastalgia and luming, or disorderly imbalance of menses.
Summary of the invention:
One of purpose of the present invention provides the drug regimen of a kind of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.
Another object of the present invention provides the preparation method of this drug regimen.
Chinese medicine of the present invention is made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made (part is unit of weight) by following raw materials according:
1. write out a prescription:
Radix Bupleuri 150-450 part Radix Paeoniae Rubra 100-300 part Radix Paeoniae Alba 100-300 part
Radix Astragali 150-450 part Pericarpium Citri Reticulatae Viride 100-300 part is amassed real 100-300 part
Radix Salviae Miltiorrhizae 150-450 part Foliumet Ramulus Evodiae 100-300 part Bombyx Batryticatus 100-300 part
Fructus Hordei Germinatus 100-300 part Rhizoma Curcumae Longae 100-300 part Myrrha 100-300 part
Spica Prunellae 100-300 part Rhizoma Pinelliae 100-300 part
The active component that preferred following raw materials according is made, curative effect is better:
150 parts of 150 portions of Radix Paeoniae Albas of 300 parts of Radix Paeoniae Rubra of Radix Bupleuri
150 parts long-pending real 150 parts on 300 parts of Pericarpium Citri Reticulatae Virides of the Radix Astragali
100 parts of 150 portions of Bombyx Batryticatus of 300 parts of Foliumet Ramulus Evodiae of Radix Salviae Miltiorrhizae
100 parts of 100 parts of Myrrhas of 150 portions of Rhizoma Curcumae Longaes of Fructus Hordei Germinatus
100 parts of 150 parts of Rhizoma Pinelliaes of Spica Prunellae
The active ingredient preparation method of Chinese medicine of the present invention can be that raw material is dry respectively, and levigation mixes.It also can be the conventional method preparation of adopting herbal pharmaceutical.These pharmacy conventional methods can be water extract-alcohol precipitation or ethanol extract from water precipitation, also have other extracting method in addition, specifically " pharmaceutics of Chinese drugs " published referring to Cao Chunlin chief editor's Shanghai science tech publishing house.
The following preparation method preparation of preferred employing:
2. preparation technology
(1) Radix Astragali, Radix Salviae Miltiorrhizae add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, long-pending reality, Foliumet Ramulus Evodiae, Bombyx Batryticatus, Fructus Hordei Germinatus, Rhizoma Curcumae Longae, Myrrha, Spica Prunellae, the Rhizoma Pinelliae decocts with water secondary, 2 hours for the first time, 1.5 hours second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
Adopt mutual compatibility of above-mentioned raw material of Chinese medicine and preparation method thereof, full side has the effect of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, is used for the caused by energy stagnation and blood stasis nodules of the breast, cyclomastopathy, and ovarian cyst, hysteromyoma is seen above-mentioned patient.
By the following examples technical scheme of the present invention is described further.
Embodiment 1: the preparation method of granule
1. write out a prescription:
150 parts of 150 portions of Radix Paeoniae Albas of 300 parts of Radix Paeoniae Rubra of Radix Bupleuri
150 parts long-pending real 150 parts on 300 parts of Pericarpium Citri Reticulatae Virides of the Radix Astragali
100 parts of 150 portions of Bombyx Batryticatus of 300 parts of Foliumet Ramulus Evodiae of Radix Salviae Miltiorrhizae
100 parts of 100 parts of Myrrhas of 150 portions of Rhizoma Curcumae Longaes of Fructus Hordei Germinatus
100 parts of 150 parts of Rhizoma Pinelliaes of Spica Prunellae
2. preparation technology:
(1) Radix Astragali, Radix Salviae Miltiorrhizae add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, long-pending reality, Foliumet Ramulus Evodiae, Bombyx Batryticatus, Fructus Hordei Germinatus, Rhizoma Curcumae Longae, Myrrha, Spica Prunellae, the Rhizoma Pinelliae decocts with water secondary, 2 hours for the first time, 1.5 hours second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds cane sugar powder, and mixing is made granule, drying, promptly.
Embodiment 2: the preparation method of tablet
1. write out a prescription:
150 parts of 150 portions of Radix Paeoniae Albas of 300 parts of Radix Paeoniae Rubra of Radix Bupleuri
150 parts long-pending real 150 parts on 300 parts of Pericarpium Citri Reticulatae Virides of the Radix Astragali
100 parts of 150 portions of Bombyx Batryticatus of 300 parts of Foliumet Ramulus Evodiae of Radix Salviae Miltiorrhizae
100 parts of 100 parts of Myrrhas of 150 portions of Rhizoma Curcumae Longaes of Fructus Hordei Germinatus
100 parts of 150 parts of Rhizoma Pinelliaes of Spica Prunellae
2. preparation technology:
(1) Radix Astragali, Radix Salviae Miltiorrhizae add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, long-pending reality, Foliumet Ramulus Evodiae, Bombyx Batryticatus, Fructus Hordei Germinatus, Rhizoma Curcumae Longae, Myrrha, Spica Prunellae, the Rhizoma Pinelliae decocts with water secondary, 2 hours for the first time, 1.5 hours second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds starch, magnesium stearate, tabletting, promptly.
Embodiment 3: the preparation method of capsule
1. write out a prescription:
150 parts of 150 portions of Radix Paeoniae Albas of 300 parts of Radix Paeoniae Rubra of Radix Bupleuri
150 parts long-pending real 150 parts on 300 parts of Pericarpium Citri Reticulatae Virides of the Radix Astragali
100 parts of 150 portions of Bombyx Batryticatus of 300 parts of Foliumet Ramulus Evodiae of Radix Salviae Miltiorrhizae
100 parts of 100 parts of Myrrhas of 150 portions of Rhizoma Curcumae Longaes of Fructus Hordei Germinatus
100 parts of 150 parts of Rhizoma Pinelliaes of Spica Prunellae
2. preparation technology:
(1) Radix Astragali, Radix Salviae Miltiorrhizae add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, long-pending reality, Foliumet Ramulus Evodiae, Bombyx Batryticatus, Fructus Hordei Germinatus, Rhizoma Curcumae Longae, Myrrha, Spica Prunellae, the Rhizoma Pinelliae decocts with water secondary, 2 hours for the first time, 1.5 hours second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, sieves, and adds starch, and mixing is made granule, and drying incapsulates, promptly.
Claims (5)
1, the drug regimen of a kind of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving is characterized in that being made up of active ingredient and/or pharmaceutically acceptable carrier, and wherein said active ingredient is made by following raw materials according:
Radix Bupleuri 150-450 part Radix Paeoniae Rubra 100-300 part Radix Paeoniae Alba 100-300 part
Radix Astragali 150-450 part Pericarpium Citri Reticulatae Viride 100-300 part is amassed real 100-300 part
Radix Salviae Miltiorrhizae 150-450 part Foliumet Ramulus Evodiae 100-300 part Bombyx Batryticatus 100-300 part
Fructus Hordei Germinatus 100-300 part Rhizoma Curcumae Longae 100-300 part Myrrha 100-300 part
Spica Prunellae 100-300 part Rhizoma Pinelliae 100-300 part
2, the drug regimen of a kind of blood circulation promoting and blood stasis dispelling according to claim 1, hard masses softening and resolving is characterized in that wherein preparing the preferred following raw materials according of described active ingredient:
150 parts of 150 portions of Radix Paeoniae Albas of 300 parts of Radix Paeoniae Rubra of Radix Bupleuri
150 parts long-pending real 150 parts on 300 parts of Pericarpium Citri Reticulatae Virides of the Radix Astragali
100 parts of 150 portions of Bombyx Batryticatus of 300 parts of Foliumet Ramulus Evodiae of Radix Salviae Miltiorrhizae
100 parts of 100 parts of Myrrhas of 150 portions of Rhizoma Curcumae Longaes of Fructus Hordei Germinatus
100 parts of 150 parts of Rhizoma Pinelliaes of Spica Prunellae
3, according to the drug regimen of the described a kind of blood circulation promoting and blood stasis dispelling of claim 1-2, hard masses softening and resolving, it is characterized in that adopting following method to make:
(1) Radix Astragali, Radix Salviae Miltiorrhizae add 75% ethanol warm macerating 30 minutes, the reflux, extract, secondary, and 2.5 hours for the first time, 2 hours for the second time, merge extractive liquid, was concentrated into the thick paste shape;
(2) get Radix Bupleuri, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Pericarpium Citri Reticulatae Viride, long-pending reality, Foliumet Ramulus Evodiae, Bombyx Batryticatus, Fructus Hordei Germinatus, Rhizoma Curcumae Longae, Myrrha, Spica Prunellae, the Rhizoma Pinelliae decocts with water secondary, 2 hours for the first time, 1.5 hours second time, filter, merging filtrate, filtrate are condensed into the clear paste that relative density is 1.08～1.14 (50～60 ℃), add 2.8 times of amount ethanol, stir evenly, be heated to 60 ℃, left standstill 24 hours, filter, decompression filtrate recycling ethanol is condensed into the thick paste shape;
(3) step (1) gained thick paste is mixed with step (2) gained thick paste, drying is ground into fine powder, adds acceptable accessories and makes different preparations such as granule, sheet, capsule.
4,, it is characterized in that this Chinese medicine composition is an oral formulations according to the drug regimen of any one described a kind of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving among the claim 1-3.
5,, it is characterized in that this Chinese medicine composition can be made into granule, capsule, tablet according to the drug regimen of the described a kind of blood circulation promoting and blood stasis dispelling of claim 3-4, hard masses softening and resolving.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101037741A CN101259250A (en) | 2008-04-10 | 2008-04-10 | Medicaments assembly for activating blood circulation and removing stasis, softening dry feces and dissipating mass and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101037741A CN101259250A (en) | 2008-04-10 | 2008-04-10 | Medicaments assembly for activating blood circulation and removing stasis, softening dry feces and dissipating mass and preparation thereof |
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| CNA2008101037741A Pending CN101259250A (en) | 2008-04-10 | 2008-04-10 | Medicaments assembly for activating blood circulation and removing stasis, softening dry feces and dissipating mass and preparation thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727673A (en) * | 2012-02-24 | 2012-10-17 | 广州加原医药科技有限公司 | Chinese medicine composition for treating hysteromyoma and preparation method thereof |
| CN103349759A (en) * | 2013-07-29 | 2013-10-16 | 黄淑娟 | Traditional Chinese medicine composition for treating ovarian cyst |
-
2008
- 2008-04-10 CN CNA2008101037741A patent/CN101259250A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727673A (en) * | 2012-02-24 | 2012-10-17 | 广州加原医药科技有限公司 | Chinese medicine composition for treating hysteromyoma and preparation method thereof |
| CN102727673B (en) * | 2012-02-24 | 2014-04-30 | 广州加原医药科技有限公司 | Chinese medicine composition for treating hysteromyoma and preparation method thereof |
| CN103349759A (en) * | 2013-07-29 | 2013-10-16 | 黄淑娟 | Traditional Chinese medicine composition for treating ovarian cyst |
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Open date: 20080910 |