CN101254234A - Antineoplastic Chinese medicinal composition of supercritical bee glue, ganoderma lucidum sporule oil and perilla oil - Google Patents
Antineoplastic Chinese medicinal composition of supercritical bee glue, ganoderma lucidum sporule oil and perilla oil Download PDFInfo
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- CN101254234A CN101254234A CNA2008100238353A CN200810023835A CN101254234A CN 101254234 A CN101254234 A CN 101254234A CN A2008100238353 A CNA2008100238353 A CN A2008100238353A CN 200810023835 A CN200810023835 A CN 200810023835A CN 101254234 A CN101254234 A CN 101254234A
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Abstract
The invention relates to a Chinese medicinal composition, particularly to an anti-tumor Chinese medicinal composition comprising (by weight parts) supercritical propolis 20-70, supercritical ganoderma lucidum spore oil 20-70, and Perilla frutescens fruit oil with anti-tumor effect 10-30. The invention uses advanced supercritical fluid separation technology to obtain supercritical propolis and supercritical ganoderma lucidum spore oil, which have the same anti-tumor effect as propolis and Ganoderma lucidum spore and have purified and concentrated anti-tumor components. The invention combines three anti-tumor components to form a Chinese medicinal composition with better anti-tumor effect.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, refer in particular to the antitumor Chinese of a kind of supercritical propolis, Ganoderma spore oil and perilla oil.The present invention utilizes advanced novel supercritical fluid isolation technics, separate supercritical propolis, the Ganoderma spore wet goods obtain and both inherited the antitumous effect of propolis, Ganoderma, purification and concentrated their antineoplastic medicinal ingredient again, the present invention is with supercritical propolis, supercritical Ganoderma Lucidum spore oil, the medicinal ingredient of three kinds of each tool antitumor characteristics of perilla oil is formed the Chinese medicine composition that has more antitumor curative effect.
Background technology
Cancer is human maximum killer, it also is the difficult problem of world today the world of medicine maximum, though various curing cancer drugs are arranged now, but can not reach ideal curative effect mostly, and the side effect of radiotherapy, chemotherapy is very big, when serious even can destroy patient's immune system, the body of injury tumour patient.
Materials such as propolis, Ganoderma, Fructus Perillae are natural cancer therapy drugs, have certain anti-cancer and anticancer effect, but use with " single " (single) mostly at present, therefore there is certain limitation, as propolis is to utilize its propolis terpenes and Flavonoid substances to come anticancer, thereby plays anti-cancer and the effect of controlling cancer.Ganoderma then is to come anticancer with the terpenes in the Ganoderma, ganoderan composition.Perilla oil is anticancer with Folium Perillae linolenic acid composition.This one-component cancer therapy drug has influenced giving full play to of therapeutic effect.
Summary of the invention
The object of the present invention is to provide the antitumor Chinese of a kind of supercritical propolis, Ganoderma spore oil and perilla oil, three kinds of anticarcinogens are combined with raw material of Chinese medicine, form the better compositions of a kind of antitumous effect.
According to technical scheme provided by the invention, the antitumor Chinese of described supercritical propolis, Ganoderma spore oil and perilla oil comprises supercritical propolis 20～70, supercritical Ganoderma Lucidum spore oil 20～70, perilla oil 10～30 with anti-tumor function, unit are weight portion.
Described perilla oil with anti-tumor function is the supercritical perilla oil.
General flavone content in the described supercritical propolis is more than 5000mg/100g; Lucidium spore powder wall breaking rate 85～99% in the described supercritical Ganoderma Lucidum spore oil, the Ganoderma triterpenoids 8～12% in the supercritical Ganoderma Lucidum spore oil; Alpha-linolenic acid content in the described perilla oil is more than 45%.Unit is a percetage by weight.
Described Chinese medicine composition be shaped as smectic, oily or powdery.
Propolis (propolis) is the resinoid that Apis is gathered collagen plant plumule and innovation leaf bud, mixes a kind of gluey natural active matter at the secretions that mixes the cured gland of Apis lingual gland.A large amount of studies show that, that propolis has is antibiotic, antiinflammatory, inhibition virus, anticancer and increase physiology and pharmacological function such as body's immunity, and contained flavonoid, terpenes, polysaccharide, enzyme, organic acid etc. have unique effect again to the cancer patient in the propolis.
Human propolis ethanol extractions such as nineteen sixty-five Derevici are observed propolis to Emhorn ascites by In vitro culture, and the influence of cancerous cell proves that the propolis ethanol extraction has obvious inhibitory action to cancerous cell nuclear.
People such as nineteen eighty-three Ban have tested propolis extract (quercetin, Fructus rhamni (Rhamnus davurica Pall.) element, galangin etc.) to the killing action of cervical cancer cell, when propolis extract concentration is 10 mg/ml, makes the growth of cancer cells ability be subjected to 50% inhibitory action.
1991, the wild wise man of National Institutes of Health,Japan pine also doctor studies have shown that the diterpene-kind compound in the propolis has the specific killing effect to tumor, the cancer patient is after taking propolis, and not only cancerous cell can disappear, and can alleviate the side effect that chemotherapy, radiotherapy cause.
1997, the wide rapids refined male Mr. of Nagoya municipal university medical board carried out the antitumaous effect research about the propolis of supercritical extraction.He is 63 female experimental mouse, with 21 be a component be A, B, C, three groups, with artificial method, make experimental mouse suffer from pulmonary carcinoma, renal cancer, thyroid carcinoma, breast carcinoma, colorectal cancer, bladder cancer.
Then with the supercritical propolis of variable concentrations and there is not the supercritical propolis bait to feed respectively to each group experimental mouse.
A group causes the supercritical propolis that is mixed with concentration 0.1% in the bait of experimental mouse of cancer suffering from the people.
B group causes the supercritical propolis that is mixed with concentration 0.01% in the bait of experimental mouse of cancer suffering from the people.
C group causes in the bait of experimental mouse of cancer not to be mixed with supercritical propolis suffering from the people.
Secondly, the female experimental mouse of reuse health is divided into two groups of D, E.
The healthy experimental mouse of D group is mixed with the propolis of 0.01% supercritical extraction in bait.
Do not add supercritical propolis in the experimental mouse bait of E group health.
Under such condition, continuous 33 weeks are feeding constantly, carries out detailed inspection termly, and experimental result is as follows:
The survival results of experimental group:
What A, B organized accounts for 86%;
C, group 70%;
D, E group 100%;
D group and E group are not carried out artificial canceration processing, and survival rate also just is higher than A, B group certainly.And A, B group experimental mouse is compared with the C group, and survival rate differs 15% also.
General cancer therapy drug is using the cancer therapy drug group and is not using the contrast of cancer therapy drug group survival rate to differ 20%, and the medicine of this cancer resistance just can be judged to effectively.
Supercritical propolis is as follows to the incidence rate and the mortality statistics that suppress cancer in experiment:
This shows that use A, the B group of supercritical propolis, the incidence rate of cancer is obviously low.Current experiment has verified that also the propolis of supercritical extraction has anticancer effect.
Doctor Wu Xiaowen of Tokyo University directly killed test to cancerous cell with supercritical propolis solution in 2003, shown in Fig. 1,2,3,4, wherein, Fig. 2～Fig. 4 shows that the anticancer active substance of propolis is made by cell streaming instrumentation cancerous cell is suppressed situation: abscissa is the DNA amount among the figure, vertical coordinate is a cell value, M
1Be cancerous cell, M
2Be M
1Cancerous cell duplicates back division stage of preparation.
The original cancerous cell of (see figure 2) is killed when concentration is 200ppm, and can not duplicate other cancerous cell again, can kill and suppress original cancerous cell though be lower than this concentration, unable obstruction regeneration cancerous cell.The 7th international bee product health care fair paper in 2004.Wu Xiao hears the example in the ガ ソ To of the show effect ぃ of institute supercritical extraction プ mouth Port リ ス (anticancer effect of the supercritical extraction propolis) book, illustrate that supercritical propolis all has good antitumor curative effect to pulmonary carcinoma, gastric cancer, esophageal carcinoma, hepatocarcinoma etc., and can prevent and reduce the side effect of chemicotherapy.
Ganoderma (Ganoderma lucidum) has long history in China, is famous food medicine dual-purpose fungus, and human body is had many-side, ten minutes good health care therapeutic efficiency.The nineties in 20th century, unit such as Chinese Medicine academy of science institute of materia medica found the Ganoderma curative effect of more renewals to studies confirm that Ganoderma has directly or auxiliary curative effect more than 360 kinds of diseases.Especially Ganoderma extract Ganodenic acid (triterpenoid compound) not only has the immunity of raising, and effects such as protecting the liver, detoxify, calm the nerves also has the effect that directly suppresses tumor growth, is the natural antitumor medicinal raw material.
The anticancer function of supercritical Ganoderma Lucidum spore oil Sino-Japan scientist studies confirm that, the Ganodenic acid in the supercritical Ganoderma Lucidum spore oil can directly be killed tumor cell, destroys the tumor cell telomerase, the control growth of tumour cell.Simultaneously can strengthen the patient immune function, kill cancerous cell, eliminate and the inhibition focus.Improve and improve quality of lifes such as tumor patient sleep, appetite, energy.
Clinical proof, Ganoderma spore oil can improve tumor patient to put, the toleration of chemotherapy, alleviate put, the toxicity of chemotherapy, as leukopenia, side effect such as loss of appetite, insomnia, vomiting, alopecia, for the tumor patient between the convalescence of operation back, can effectively prevent and treat recurrence, diffusion, shift.Ganoderma spore oil is to entering the tumor patient in late period, and owing to reasons such as weak or agings, the treatment that both can't undergo surgery can't be put again, chemotherapy, and Ganoderma spore oil can ease the pain, and improves life quality, delayed death.
Ganoderma spore oil and Western medicine have share synergism.And the side effect that can lower Western medicine, also can be used as the ancillary drug of medical treatment.
Perilla oil (perillaseed oil) is the extract in the Folium Perillae fruit.Two kinds of extracting method of useful ethanol and supercritical fluid obtain.Pharmacological research proves that perilla oil is rich in the alpha-linolenic acid system of needed by human, the unsaturated fatty acid of ω-3 series, and it has the physiologically active of Chinese medicine.Guangzhou medical industries institute, the pharmacology and the toxicological experiment that carry out the blood fat reducing of supercritical perilla oil prove that perilla oil has tangible blood lipid regulation effect and without any side effects.
Perilla oil can activating brain cell, and memory reinforcing is prevented and treated senile dementia and had the effect that cancer takes place and shifts that suppresses.Be firmly established in the international conference of the ω that March nineteen ninety, held in Washington-3 series fatty acid.
The supercritical propolis patent of invention that the inventor has " method of the hybrid bee glue extracting of a kind of supercritical fluid ", the patent No. 031317529 are for the invention provides high-quality supercritical propolis.
The present invention passes on the Chinese Medicine characteristic, and Chinese medicine is to form with " multi-flavor " natural drug to complement each other, short mutually effect, and to increase therapeutic effect, this is a traditional Chinese medical science marrow.The present invention with modern advanced supercritical liquid extraction technique, extracts spissated, no solvent residue with propolis, Ganoderma, three kinds of natural anti-cancer materials of perilla oil, purified supercritical propolis, supercritical Ganoderma Lucidum spore oil, perilla oil combination.The present composition has had anticancer property compositions such as propolis terpenes, flavone, Ganoderma terpenes, ganoderan, Folium Perillae linolenic acid, reach complement each other, complementary potentiation, promote the antitumor Chinese of anticancer effect.This compositions is based on the advanced science extractive technique of supercritical, is different from general mixture.
The inventor in China and Japanese antineoplastic are studied, with supercritical propolis, Ganoderma spore oil, the composition of perilla oil three scientific combination makes its antitumor curative effect be much better than propolis, Ganoderma, the single composition of perilla oil.Utilize flavonoid main in the supercritical propolis and terpenes (propolis diterpene, triterpene) antineoplastic functional component, Ganodenic acid (ganoderma lucidum triterpene compounds) the antitumor efficacy composition that enriches in the supercritical Ganoderma Lucidum spore oil, and the antitumor character composition that alpha-linolenic acid has in the supercritical perilla oil.With the material of these three kinds of each tool characteristics, in antitumor curative effect separately, brought into play unique separately antitumor action, and obtained clinical confirmation, social sanction.
Description of drawings
Cancerous cell sample measurement result when Fig. 1 does not add specific effective ingredient;
Fig. 2 concentration is the specific effective constituent determination result of 200ppm;
Measurement result when Fig. 3 concentration is the specific effective ingredient of 40ppm;
Measurement result when Fig. 4 concentration is the specific effective ingredient of 20ppm.
The specific embodiment
The unit of following embodiment is weight portion.
Embodiment one
70 parts of present composition supercritical propoliss, 20 parts of supercritical Ganoderma Lucidum spore oil, 10 parts of supercritical perilla oils, supercritical propolis: supercritical spore oil: the ratio of supercritical perilla oil is 7: 2: 1.
Embodiment two
The present composition: 60 parts of supercritical propoliss, 25 parts of supercritical Ganoderma Lucidum spore oil, supercritical perilla oil 15%.Propolis: Ganoderma spore oil: perilla oil, ratio are 6: 2.5: 1.5.
Embodiment three
Press the present composition: 50 parts of supercritical propoliss, 30 parts of supercritical Ganoderma Lucidum spore oil, 20 parts of supercritical perilla oils.Propolis: Ganoderma spore oil: perilla oil, ratio are 5: 3: 2.
Embodiment four
Press the present composition: 40 parts of supercritical propoliss, 35 parts of supercritical Ganoderma Lucidum spore oil, 25 parts of supercritical perilla oils.Propolis: Ganoderma spore oil: perilla oil, ratio are 4: 3.5: 2.5.
Embodiment five
Press the present composition: 30 parts of supercritical propoliss, 40 parts of supercritical Ganoderma Lucidum spore oil, 30 parts of supercritical perilla oils.Propolis: Ganoderma spore oil: the ratio of perilla oil is 3: 4: 3.
Embodiment six
Press the present composition: 20 parts of supercritical propoliss, 70 parts of supercritical Ganoderma Lucidum spore oil, 10 parts of supercritical perilla oils.Propolis: Ganoderma spore oil: perilla oil, ratio are 2: 7: 1.
The present invention and single composition antitumous effect are compared as follows
The present invention carries out the clinical case experimentation, confirms the supercritical propolis Ganoderma spore, and the Fructus Perillae anti-tumor compositions has antitumor curative effect, and representative instance is as follows:
1, the Mr. Zhang of [colon cancer patient] Wuxi, 61 years old.Make a definite diagnosis colon cancer in JIUYUE, 2004, and in the existing lymph metastasis of abdominal cavity and clavicle nest, in the treatment of Rui Jin, Shanghai hospital surgical, the postoperative chemotherapy significant reaction, with vomiting, feel sick, whole-body muscle joint pain unbearably, leukocyte, platelet obviously drop.
Examination is taken in the process of compositions of the foregoing description one, and chemotherapy side effect obviously weakens, and in the just for one day, at injection one side disease of hand, vein pain just recovered as usual in second day during chemotherapy.
Hemogram contrast before and after taking: leukocyte rises to 8200 from 4100, hemoglobin rises to 12.1 from 10.8, colon cancer antigen drops to 0.5 μ/ml from 12 μ/ml, ferritin drops to 751.6ng/ml (normal value is 13-400ng/ml) from 1121ng/ml, after the patient takes the present composition, immunoglobulin G, IgM all take an evident turn for the better, and the immunologic function chemotherapy side effect that increases obviously alleviates, and the index reflection has certain tumor-inhibiting action.
2, Mr. Zhu in [malignant lymphoma patient] Jiangyin, 71 years old, be diagnosed as malignant lymphoma (chemotherapy 8 times) in July, 2000, bladder cancer appearred in 2005, chemotherapy side effect is obvious, whole-body muscle joint aches, weak, alopecia, anorexia, leukocyte, granulocyte numeration, hemoglobin, erythrocyte, platelet etc. are drop obviously.The compositions that embodiment two is taken in examination.Patient's sensation, effect is obviously felt good, and chemotherapy side effect does not almost have, and appetite stimulator, improves sleep.The oncotherapy of raising effect is arranged.
Hemogram contrast before and after taking: leukocyte rises to 3800 from 1400, and the granulocyte numeration rises to 2.8 from 0.8, and hemoglobin rises to 134 from 121, and erythrocyte rises to 37.2 from 33.3, and platelet rises to 169 from 140.
3, the Miss Wu in [patients with gastric cancer] Xi'an, 71 years old, feel that for a long time digestive system is uncomfortable, make a definite diagnosis in April, 2006, and cancer spreads, and adhesions such as stomach, spleen and duodenum can't be performed the operation, and in the chemotherapy process, reaction is serious, vomiting, pain, the patient is based on bed.More hydrops is arranged in the abdominal cavity, abdominal distention uncomfortable in chest, it is powerless that the doctor feels.Take in the compositions process of embodiment three, effect progressively manifests, and transfers the energy light activity to from bed, further does simple housework, and the more preceding improvement of the mental status has alleviated patient's misery, has improved patient's life quality.
4, the Mr. Chen of [patients with lung cancer] Wuxi is 65 years old, upper left lung tumor wedge excision in 2000, original position recurrence in 2003, the operation of Shanghai chest hospital.Shifting left clavicle lymph node and peritoneum in 2004 also has lymph node, successively is in hospital 2 operations of 13 chemotherapy, 2-3 immunotherapy and herbal treatment for 18 times.
The compositions that on April 18th, 2005 began to try to take embodiment four, take the preceding patient's condition: left thoracic wall pain, need take 3 of analgesic (oral 2,1 of anus plug) inappetence every day, myasthenia of limbs, hands, foot, back of the body edema.
Effect sees Table (one month each course of treatment) after taking the present composition
| Take the course of treatment | Take the back dominant response |
| First course of treatment | Diarrhoea stench (toxin expelling), analgesic reduces, and reduces to 1 from 3 |
| Second course of treatment | Spirit takes a turn for the better, and sleep takes a turn for the better |
| The 3rd course of treatment | Appetite improves, and red gas has improved the complexion |
| The 4th course of treatment | Pain relief, analgesic can be taken at interval |
| The 5th course of treatment | The instep edema disappears |
| The 6th course of treatment | Can participate in outdoor exercise downstairs |
Patient Zhu Xiansheng narration:
After I take, feel to truly have curative effect, body constitution obviously strengthens, and feels the state of an illness taking a turn for the better, and has strengthened confidence and courage that I " live on ".
Claims (4)
1, the antitumor Chinese of a kind of supercritical propolis, Ganoderma spore oil and perilla oil, it is characterized in that, this Chinese medicine composition comprises supercritical propolis 20%～70%, and supercritical Ganoderma Lucidum spore oil 20%～70% has the perilla oil 10%～30% of anti-tumor function.
2, Chinese medicine composition according to claim 1 is characterized in that: described perilla oil with anti-tumor function is the supercritical perilla oil.
3, Chinese medicine composition according to claim 1 is characterized in that: the general flavone content in the described supercritical propolis is more than 5000mg/100g; Lucidium spore powder wall breaking rate 85～99% in the described supercritical Ganoderma Lucidum spore oil, the Ganoderma triterpenoids 8～12% in the supercritical Ganoderma Lucidum spore oil; Alpha-linolenic acid content in the described perilla oil is more than 45%.
4, according to right 1 described Chinese medicine composition, it is characterized in that: described Chinese medicine composition be shaped as smectic, oily or powdery.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797282A (en) * | 2010-04-07 | 2010-08-11 | 扬州大学 | Novel compound propolis preparation and preparation method thereof |
| CN101810674A (en) * | 2010-05-10 | 2010-08-25 | 南京中科药业有限公司 | Chinese medicinal composition for enhancing immunity, and preparation method thereof |
| CN105477100A (en) * | 2015-12-23 | 2016-04-13 | 无锡瑞盈生命科学有限公司 | Lucid ganoderma spore oil compound health care spray and preparation method |
| CN105767996A (en) * | 2016-03-03 | 2016-07-20 | 扬州三邦生物工程有限公司 | Three health-care ingredient contained propolis and preparation technology thereof |
-
2008
- 2008-04-17 CN CNA2008100238353A patent/CN101254234A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101797282A (en) * | 2010-04-07 | 2010-08-11 | 扬州大学 | Novel compound propolis preparation and preparation method thereof |
| CN101810674A (en) * | 2010-05-10 | 2010-08-25 | 南京中科药业有限公司 | Chinese medicinal composition for enhancing immunity, and preparation method thereof |
| CN101810674B (en) * | 2010-05-10 | 2012-11-07 | 南京中科药业有限公司 | Chinese medicinal composition for enhancing immunity, and preparation method thereof |
| CN105477100A (en) * | 2015-12-23 | 2016-04-13 | 无锡瑞盈生命科学有限公司 | Lucid ganoderma spore oil compound health care spray and preparation method |
| CN105767996A (en) * | 2016-03-03 | 2016-07-20 | 扬州三邦生物工程有限公司 | Three health-care ingredient contained propolis and preparation technology thereof |
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