CN101530589B - Chinese medicinal preparation for treating cancers - Google Patents
Chinese medicinal preparation for treating cancers Download PDFInfo
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- CN101530589B CN101530589B CN2009100384617A CN200910038461A CN101530589B CN 101530589 B CN101530589 B CN 101530589B CN 2009100384617 A CN2009100384617 A CN 2009100384617A CN 200910038461 A CN200910038461 A CN 200910038461A CN 101530589 B CN101530589 B CN 101530589B
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Abstract
The invention belongs to the field of pharmacy and particularly relates to a medicament for treating esophagus cancers, liver cancers and stomach cancers. The medicament is prepared by twenty Chinese medicines, such as selected pearls, artificial bezoar, dragon's blood, notoginseng, artificial musk, borneol, ambers, Chinese eaglewood, bamboo sugar and the like, and takes heat clearing and toxin releasing, blood circulation activation to dissipate blood stasis, phlegm dispersion and mass dissipation, and right support and root banking up as therapeutic principles. The raw medicinal materials are purified, cut, processed, steamed, dried and extracted for effective components respectively and prepared into capsules. The medicament prepared by the formulation has the advantages of no toxicity and no side effect and has the effects of preventing and treating esophagus cancers, liver cancers and stomach cancers.
Description
Technical field
The invention belongs to pharmaceutical field, particularly a kind of medicine for the treatment of esophageal carcinoma, hepatocarcinoma, gastric cancer.
Background technology
Cancer is commonly encountered diseases, the frequently-occurring disease of a kind of serious threat people's life and health.In China, annual newfound cancer patient is about 1,600,000, dies from about 1,300,000 people of cancer, and the band cancer survivor is about millions of people also, and this brings very large misfortune to patient family, and is also very serious to the harm of society.
In China, Incidence of esophageal cancer is higher." Chinese mortality of malignant tumors investigation " according to publication in 1979 shows, area, the Taihang Mountains, North China such as China Henan, Hebei, Shanxi four Esophageal Cancer in High Risk Areas.From the investigation to Linxian, henan Province Yao Cun, find that Yao Cun area 1970-1979 male esophageal cancer patient 10 annual mortality rates are 289.7/10 ten thousand, the women is 218.3/10 ten thousand.South China In Northwest of Sichuan Basin Yanting County and Nanao, Guangdong Province county also are Esophageal Cancer in High Risk Areas, and its esophageal carcinoma average mortality is non-not to be 100.9/10 ten thousand and 79.3/10 ten thousand.In addition, with provinces such as Jiangsu, Shandong, Fujian, Shaanxi the relative district occurred frequently of concentrating of this disease is arranged also in the Xinjiang Uygur Autonomous Regions.The cancer such as gastric cancer, hepatocarcinoma is also seriously threatening the people's life with healthy.Again according to statistics, the whole world has nearly 9,000,000 people that tumor occurs every year, and death toll reaches 7,000,000, causes huge pressure for people's spirit.This is owing to inadequate to the theoretic knowledge for the treatment of and prevention of tumour on the one hand, the more important thing is on the medicine and can not satisfy the treatment needs.We defeat the medicine of this fearful disease in the urgent need to development.
The traditional Chinese medical science is strengthening vital QI to eliminate pathogenic factors to the Therapeutic Principle of cancer, clinical in mainly take " the body resistance strengthening and constitution consolidating, heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, vanishing sputum and dispelling knot " these four method for the treatment of as main.
Activating blood and removing stasis Method is the prevention of cancer, the main method for the treatment of and preventing from recurring, and the generation of cancer and qi depression to blood stasis have certain relation.Superior doctor treating the disease before its onset, the generation of prophylaxis of cancer should be used first activating blood and removing stasis Method, dispels the stagnant gas blood stasis in the body, makes that cancerous cell can not be built up in vivo, hypertrophy.Tumor is existing, then uses blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds.Behind the operation chemicotherapy, mostly transfer and relapse appears in cancer patient, how because cancerous cell produces the cell bolt by blood circulation, accumulates in each qi-blood circulating of whole body such as internal organs part of being obstructed.Therefore, in clinical practice, activating blood and removing stasis Method occurs in prophylaxis of cancer, eliminates focus, prevents its transfer and relapse all to obtain certain curative effect.
Chinese medicine said " expectorant " refers to that viscera is qi-blood disharmony, body fluid dysfunction of the spleen in transportation and transformation and the pathological product that produces is again the paathogenic factor of many difficult miscellaneous diseases simultaneously.Expectorant has played the effect of adding fuel to the flames especially in the forming process of cancer, especially expectorant is turbid associates with blood stasis, each other knot.Reduce phlegm and lead turbid and so on Chinese herbal medicine and can not only remove pathology rubbish, deeply smash the carcinoma nest, but the also direct killing and the anticancer that have.The hard masses softening and resolving medicine can make carcinoma inner soft and loose it, clear away the obstacles for cancer therapy drug enters the tumor body.
The inventor is from the Overall View of the traditional Chinese medical science, draw successive dynasties medical science ancient books and records elite, widely collect the folk secret nostrum, through the clinical research in 40 years, selected 20 flavor medicine compatibilities were take heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, vanishing sputum and dispelling knot, the body resistance strengthening and constitution consolidating as the rule for the treatment of, do not adopt the Therapeutic Method for the treatment of the poisonous disease with poisonous drugs, use " monarch, minister, help, make " theory of the traditional Chinese medical science, all medicines of prescription share, and development has the medicine of prevention and therapeutic effect.
Summary of the invention
The purpose of this invention is to provide a kind of pharmaceutical composition with treatment esophageal carcinoma, gastric cancer, hepatocarcinoma that is comprised of Chinese medicine, this medicine no side effects has prevention and treatment cancer, particularly esophageal carcinoma, gastric cancer, hepatocarcinoma effect.
The medicine for the treatment of esophageal carcinoma of the present invention, gastric cancer, hepatocarcinoma, make (consumption is weight ratio) by following component:
Medicine of the present invention, each raw material optimum ratio (weight ratio) is:
Wherein said Bombyx Batryticatus is that the Sucus Zingberis processing is made, and Lapis Micae Aureus is that calcination processing is made.
The present invention treats the medicine of esophageal carcinoma, gastric cancer, hepatocarcinoma, and its medicament can be capsule, powder, powder.
Medicine of the present invention shows by clinical observation and experimentation: this medicine is inhibited to esophageal carcinoma, hepatocarcinoma, gastric cancer; Radiotherapy to esophageal carcinoma, hepatocarcinoma, patients with gastric cancer has synergism.Leukopenia, atrophy of immune organ, the transaminase of the caused by chemotherapeutic medicines toxic and side effects such as raise, lose weight there is obvious antagonism.Can improve body's immunity, suppress cancer return.Can reduce feeling sick due to radiotherapy, the chemotherapy, vomiting, alopecia, become thin, esophagus is congested, edema, block, the symptom such as pain, constipation in the heart.Has certain analgesic effect.
Description of drawings
Fig. 1 is the pre-treating technology flow process of each raw material of medicine of the present invention;
Fig. 2 is the preparation technology flow process of medicine material of the present invention after pre-treatment.
Pharmacodynamic study of the present invention
Jointly inquire into medicine of the present invention to antitumaous effect and the mechanism thereof of human esophagus cancer by Medical College of Shantou University Atorvastatin system, pharmacological room of Tumour Inst., Chinese Medical Academy and Zhongshan Medical Univ.'s Experimental Animal Center.Method: use light microscopic, transmission electron microscope and flow cytometer, observe the effect of the esophageal cancer cell line EC 109 apoptosis of the drug-induced In vitro culture of the present invention; Use the Nude Mice Transplanted Tumor of Human Esophageal model, observe the antitumaous effect of medicine of the present invention.Result: external, typical apoptosis feature occurs through the EC109 of drug treating of the present invention cell.In vivo, 3 dosage of medicine of the present invention (4800mg/kg.bw, 2400mg/kg.bw, 1200mg/kg.bw) are respectively 70.80%～75.00% (P＜0.01), 58.33%～64.71% (P＜0.01), 37.04%～45.10% (P＜0.01) to the tumour inhibiting rate of the human esophagus cancer that nude mice is transplanted, and positive control Bleomycin A5 (15mg/kg.bw) is 51.33%～60.78% (P＜0.01) to the tumour inhibiting rate of the human esophagus cancer that nude mice is transplanted.Conclusion: medicine of the present invention has an effect of inducing human esophagus cancer cell to produce apoptosis external, and this may be the important mechanism of medicine anti esophageal cancer of the present invention effect.Under the dosage that nude mice can tolerate, the human esophagus cancer that medicine of the present invention is transplanted nude mice has obvious antitumaous effect, and along with dosage increases, its anticancer therapeutic increases, and is regular dose-effect relationship.
Treat people's poorly differentiated adenocarcinoma cancer SGC-7901 and people's stomach well-differentiated adenocarcinoma MKN-28 Orthotopic implantation in nude mice model respectively with medicine of the present invention at Medical College of Shantou University Atorvastatin system and Xiamen University anticancer research center.Experiment divides 5 groups: medicine high concentration group of the present invention (4800mg/kgbw), middle concentration group (2400mg/kgbw), low concentration group (1200mg/kgbw) and positive controls (ametycin 1mg/kgbw) and negative control group (normal saline).Medicine gastric infusion of the present invention, every day 2 times, successive administration 40 times, the administration of ametycin subcutaneous injection, per 2 days 1 time, altogether administration is 10 times, experiment with the increase in life span of lotus people gastric cancer in nude mice, stomach index, serum sialic acid (SA) content as index of assessment of curative effect.Experiment repeats 3 times.The result: 1. high, medium and low three dosage of medicine of the present invention are respectively 57.78%-72.03% (P＜0.01) to lotus people gastric cancer SGC-7901 nude mice increase in life span; 42.22%-56.59% (P＜0.01), 28.13%-33.79% (P＜0.01), the positive control ametycin is 52.85%-60.02% (P＜0.01) to lotus people gastric cancer SGC-7901 nude mice increase in life span; 2. after medicine height of the present invention, middle dosage treatment, stomach index, the Serum SA content of lotus people gastric cancer MKN-28 nude mice significantly reduce (P＜0.01 or P＜0.05).Conclusion: under the dosage that nude mice can tolerate, medicine of the present invention all has obvious antitumaous effect to people's poorly differentiated adenocarcinoma cancer SGC-7901 and people's stomach well-differentiated adenocarcinoma MKN-28 of Orthotopic implantation in nude mice, and along with dosage increases, its anticancer therapeutic strengthens.
The used medicine of the present invention of medical animal experiment section of Zhongshan Medical Univ. and Medical College of Shantou University tumor research is treated the nude mice of Transplanted Human hepatocarcinoma after 6 days, experiment is divided into five groups: medicine high concentration group of the present invention (4.8g/kg), middle concentration group (2.4g/kg), low concentration group (1.2g/kg), positive controls (5-fluorouracil 50mg/kg) and negative control group (normal saline), medicine gastric infusion of the present invention, every day secondary, successive administration 72 times, the 5-fluorouracil intraperitoneal injection, per two days once, and administration is 18 times altogether.Experiment as index of assessment of curative effect, is tested triplicate with tumour inhibiting rate, tumor bearing nude mice serum alpha-fetoprotein (AFP) content, cancerous cell density and karyokinesis.The result: the high, medium and low dosage of medicine of the present invention is respectively the tumour inhibiting rate of hepatocarcinoma: 59.46%～67.50% (P＜0.010), 42.36%～50.00% (P＜0.01), 30.41%～38.75% (P＜0.01), the tumour inhibiting rate of positive control 5-fluorouracil is 56.88%～60.42% (P＜0.01), and the AFP of each treatment group, cancerous cell density and karyokinesis number reduce (P＜0.05 or P＜0.01) than negative control group respectively.Conclusion: under the dosage that nude mice can tolerate, the human hepatocellular that medicine of the present invention is transplanted nude mice has obvious antitumaous effect, and along with dosage increases, its anticancer therapeutic increases.
Above-mentioned experiment shows: human body esophageal carcinoma, hepatocarcinoma, gastric cancer that medicine of the present invention is transplanted nude mice have obvious antitumaous effect.
Medicine of the present invention all has the notable synergistic Attenuation to anticarcinogens such as chemotherapeutics cyclophosphamide (CTX), 5-fluorouracil and mitomycins, illustrates that the scope of its efficacy enhancing and toxicity reducing effect is more extensive, is not limited to a certain cancer therapy drug.
Table 1 medicine of the present invention is on the impact of CTX antitumor curative effect
*.
*.
* *: the V group is P＜0.01 relatively
*.
*: compare P＜0.01, P＜0.05 with the I group
Table 2 medicine of the present invention is on the impact of 5-Fu antitumor curative effect
*.
*.
* *: compare P＜0.01 with the V group
*.
*With: the I group is P＜0.05 relatively, P＞0.05
Radiotherapy+medicine of the present invention and radiation alone relatively (when radiotherapy DT reaches 4000CGY) complete remission rate improve more than 3 times.
(when radiotherapy DT reaches 4000CGY) complete remission rate improves more than 1 times, and the quality of life after medicine of the present invention+combination radiotherapy group patient treats significantly improves than the radiation alone group, and can improve patient's immunologic function.Obvious Attenuation is arranged.
Drug toxicology research of the present invention:
1. acute toxicity test: substantially nontoxic
2. long term toxicity test: substantially nontoxic
This medicine carries out animal acute toxicity test and long term toxicity test through medical animal experiment section of Zhongshan Medical Univ., and medicine of the present invention is tested 40 NIH mouse gavagings, by 48g/kg (be equivalent to the clinical recommendation consumption of people 500 times).Gavage the behavioral activity of 10 days mices of Continuous Observation behind the medicine of the present invention, the death condition of breathing, appetite, defecation, body weight, the result: 40 NIH mices all survive, the mice bodily form is normal, and is dense, glossy by hair, motion is quick, active strong, eyes are scarlet, breathe normal, defecation is normal, appetite is good, and body weight natural increase shows that medicine of the present invention is substantially nontoxic to the NIH mice.
Medicine of the present invention is to the long term toxicity test of SD rat: 120 rats are divided into high dose group 20g/kg body weight, low dose group 4g/kg body weight, three experimental grouies of normal saline group, every group of 40 rats, continuously gavage is 180 days, continuously gavage after 90 days (put to death 1/4 rat and drug withdrawal after 15 days 1/4 rat slaughter); Remaining 60 rats continued gavage after 90 days, put to death equally 1/4 rat and drug withdrawal after 15 days 1/4 rat slaughter, 120 rat experiment results, the result shows:
1. gavage continuous 180 days body weight gains to the SD rat of medicine of the present invention, the weight/power ratio of main organs, liver function, renal function, hemogram and matched group relatively there are no significant difference.
2. on organs and tissues structures such as the heart, liver, spleen, lung, kidney, adrenal gland, gonads without impact, in sum, gavage for a long time medicine of the present invention by 20g/kg (be equivalent to the people and recommend 50 times of consumption), do not observe obvious chronic toxicity.Safety is taken in prompting.
The preclinical pharmacodynamics of San experiment shows that this medical instrument has obvious tumor-inhibiting action, share with the anti-tumor medicine thing, and the efficacy enhancing and toxicity reducing effect is arranged.
Clinical trial
Medicine of the present invention carries out clinical preliminary test by Guangdong Provincial TCM Hospital: treatment advanced liver cancer, the esophageal carcinoma, Patients with Gastric Cancer, remission rate reaches 16.7%, accounts for 91.7% more than stablizing.
Five hospitals headed by Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine, the Guangzhou tumour hospital of Zhongshan Medical Univ. carry out clinical trial, total case 305 examples.Chinese drug-treated group (medicine of the present invention) 103 examples wherein, CR:0 example, PR:11 example; Medicine+combination radiotherapy group 102 examples of the present invention, CR:41 example, PR:55 example: combination radiotherapy group 100 examples, CR:19 example, PR:72 example.Medicine+combination radiotherapy group of the present invention and combination radiotherapy group contrast, P＜0.05, significant difference.See Table 3
Table 3 tumor body change list
Example effective percentage (%)
CR PR NR PD
Number (CR+PR)
Medicine 103 0 11 85 7 10.68% of the present invention
4000CGY 102 13 55 34 0 66.7％
Medicine+combination radiotherapy group of the present invention
6000CGY 102 41 55 5 1 94.1％
4000CGY 100 3 39 58 0 42％
Combination radiotherapy group
6000CGY 100 19 72 9 0 91％
The combination of Chinese and Western medicine is cancer Colligation Therapy Mode with Chinese characteristics, is the better scheme for the treatment of at present cancer, particularly for the middle and terminal cancer patient.Western medicine kills that the ability of killing and wounding cancerous cell is stronger, and short term effect is better, but because the toxic and side effects of chemotherapeutic, for most of tumors, alone Western medicine chemotherapy can not improve cure rate, prolongs life cycle, improve life quality.The growth of Chinese medicine energy establishment cancerous cell, the life quality, the long-term effect that improve patient are better.Organically western medical treatment means and traditional Chinese medical herbal treatment are combined, not only can effectively kill cancerous cell, and can also improve patient's immunity, life quality, the toxic and side effects of reduction chemotherapy and radiation, reduce relapse rate, improve survival rate etc.
Medicine of the present invention is verified from scientific research and clinical research: medicine of the present invention is the efficient cancer therapy drug of low toxicity, can provide safely and effectively medicine for numerous cancer patients, develop the unique advantage of Chinese medicine, improve cancer patient's survival rate and cure rate, raising is to the level of preventing and treating of cancer, improve people ' s health quality and national basic quality, performance social benefit and a society bring economic benefit.Its research and development success is broken new road for Traditional Chinese Drug Anticancer, captures cancer for the combination of Chinese and Western medicine, and new weapon is provided.
The specific embodiment
Embodiment
Get each raw material by following prescription:
Margarita 20g artificial Calculus Bovis 20g Sanguis Draxonis 20g Radix Notoginseng 60g
Artificial Moschus 12g Borneolum Syntheticum 12g succinum 20g Lignum Aquilariae Resinatum 20g
Concretio Silicea Bambusae 24g Bulbus Fritillariae Cirrhosae 24g Bombyx Batryticatus (stir-frying with ginger juice) 24g Lapis Micae Aureus (forging) 24g
Radix Et Rhizoma Rhei 60g Radix Panacis Quinquefolii 20g Radix Astragali 20g Hippocampus 20g
Radix Bupleuri 25g Radix Paeoniae Alba 25g Fructus Amomi 25g Herba Pogostemonis 25g
With reference to figure 1, Fig. 2 flow process, according to the heterogeneity of medical material, crude drug is adopted respectively clean system, cutting, process of preparing Chinese medicine ball milling, Ball-milling Time 2-3 days, cross 200 mesh sieves; Steam 121 ℃ of steaming temperatures, 0.11MPa, time 45min; Drying time, 16-24h processed for 50-80 ℃, and Bombyx Batryticatus is wherein processed through Sucus Zingberis, and Lapis Micae Aureus is through calcination processing.Medical material after the processing respectively splendid attire the clean medical material for preparing, adopts on request and pulverizes in the airtight transfer container of cleaning, sieves, and the methods such as mixing sterilization are made medicated powder (semi-finished product).Medicated powder is chosen the capsule polishing on request through filling, the plastic-aluminum inner packing, and the operations such as outer package are made finished product.
More than 20 flavors make altogether 1250 of capsules (every 0.4g)
Actual production can be by every batch of clean medical material of 12.5 ten thousand capsules prescription ingredients, 20 flavors, and the medical material total amount is 50kg, the lubricant when other joins the 0.15kg magnesium stearate as filling.
Usage and consumption: oral for what make, one time 6,3 times on the one.
Several examples of " medicine of the present invention " treatment cancer
Case 1
Patient father-in-law xx, man, 56 years old.Because the carrying out property dysphagia companion pain over the chest and back was gone to a doctor in three months.Through the esophageal barium meal radiography: Upper Esophageal Carcinoma focus 5cm mucosa is damaged, narrow, stiff, the barium agent is by slowly, examines to be the esophageal carcinoma.Pathological diagnosis is squamous cell carcinoma.At present clinical manifestation: dysphagia, chest and diaphragm feeling of fullness, thoracic dorsal causalgia, the mouth saliva of spitting, dry mouth and parching tongue. constipation with dry stool, red tongue has ecchymosis, yellowish fur, supraclavicular lymph nodes.Lab testing, hematuria are just conventional, ALT, and Cr, BUN and electrocardiogram are all normal, body weight 44kg, quality of life KShi score is 70 minutes.Be diagnosed as upper segment esophageal carcinoma (mid-term).Chinese medical discrimination is the cohesion of the expectorant stasis of blood, the scorchingly hot card that pents up.
Namely give medicine of the present invention, each 6, day takes three times.During clothes to month, the full vexed and thoracic dorsal causalgia of dysphagia, chest and diaphragm alleviates.Spit saliva, constipation with dry stool of dry mouth and parching tongue, mouth disappears.Yellow fur, tongue with ecchymosis also disappear.Esophageal barium meal checks: Upper Esophageal has the mucosa of 2cm not yet to repair, and is narrowless, slightly stiff, the barium agent by before smoothly.
Through controlling 2 months, Upper Esophageal has the mucosa of 1cm not repair, and expansion ratio is good, and barium meal is by smooth.The just routine examination of clinical symptom disappearance, hematuria, electrocardiogram, liver function ALT, kidney merit Cr, BUN are all normal, and body weight increases to 48Kg, and quality of life is 90 minutes, and efficacy determination is PR.
Case 2
Mrs Lin has accepted Radical Colectomy for Carcinoma of Colon, and the symptoms such as Mrs Lin of postoperative combined with chemotherapy bitter taste, dry pharynx, anorexia have occurred, feels sick, vomiting, insomnia and then because her leukocyte and platelet are seriously on the low side, have to stop chemotherapy.At this moment Mrs Lin of anxiety has accepted traditional Chinese medical science adjustment treatment, takes " medicine of the present invention ", and health recovers gradually after three months.
Case 3
Wu X X, the man, make a definite diagnosis liver cancer recurrence after, it is faster that sb.'s illness took a turn for the worse, two side of body distending pains, a day light night is heavy, lack of appetite is indigestion and loss of appetite, emaciation and sallow complexion, oliguria with reddish urine, moving then asthma, lump appears in the hepatic region, the edge is not whole, parched lips red tongue, yellow fur are without Tianjin, stringy pulse flood band is tied, breast hydrops ascites is obvious.With medicine of the present invention, each 3 grams, every day 3 times, boiled water takes after meal.February is treated in upper ruling by law, and daily life is normal, and appetite increases than before sick, and body weight increases by 3 kilograms, can do electric appliances service work.Check: Type B ultrasonoscopy report: hepatomegaly is little normal, has no occupy-place, and common bile duct is not expanded, and the pancreas splenomegaly is little normal, kidney form no abnormality seen.
Case 4
Old X X, the man can lay one's hand on and Huge mass under right flank and the xiphoid-process, by it hard pain, can not change one's position, and lack of appetite is indigestion and loss of appetite, emaciation and sallow complexion, urinary obstruction, deep red tongue, yellow fur is thick in Tianjin, and hepatic region paroxysmal pain day at light night is heavy, stringy pulse flood band knot.Intend medicine of the present invention, each 3 grams, every day 3 times, boiled water takes after meal.The main suit took medicine three months, and daily life is normal.Resumed work in July, 94 1 year, body weight increases more than 20 jin, and appetite does not increase before sick, advises with medicine informal dress of the present invention, and with LIUWEI DIHUANG TANG (Radix Rehmanniae, Fructus Corni, Cortex Moutan, Rhizoma Alismatis, Rhizoma Dioscoreae, Poria etc.) replenishing the kidney(water)to nourish the liver(wood), ginseng stilbene five Siberian cocklebur soup are foster just eliminating evil, ridging is educated wood to be apt to thereafter.
Tracking is followed up a case by regular visits to, and lump disappears, still can work.
Case 5
Lee X X, the woman, original gastric ulcer case history 8 years, adenocarcinoma of stomach is suspected hepatic metastases, can not perform the operation, and only does hemostasis and processes.The patient becomes thin, pale complexion, and anemia, moving then asthma can't be taken food, constipation, eating in the morning but vomiting out in the evening, tongue with ecchymosis, deep and faint pulse band knot.Intend the method with QI invigorating, stopping nausea and vomiting by lowering the adverse flow of QI, dispersing the stagnated liver-QI for regulating the stomach in blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, the accent, with medicine of the present invention (each 3g, every day 3 times.February is treated in upper ruling by law, the daily life normal, and clinical symptom disappearance, body weight increases by 3 kilograms.The continuous method of using is treated.Follow up a case by regular visits to after 5 years: the patient has rosy cheeks, and before the healthy and strong victory, body weight increases more than ten kilogram, and retirement is gone home, and work can do housework.
Chinese medicine is for cancer not only with a long history, rich connotation, and selectable method is a lot, can aid in operation, radiotherapy, chemotherapy, also can use separately.Now more and more be subject to attracting attention of common people, especially centering, patients with advanced cancer, Chinese medicine improve the existence amount, significant aspect prolonging life cycle.
Claims (3)
1. medicine for the treatment of esophageal carcinoma is characterized in that it is the medicament of being made by the raw material of following weight proportioning:
2. the medicine for the treatment of esophageal carcinoma according to claim 1, wherein the weight ratio of each raw material is:
Wherein said Bombyx Batryticatus is that Sucus Zingberis is made, and Lapis Micae Aureus is calcine.
3. the medicine for the treatment of esophageal carcinoma according to claim 1 and 2 is characterized in that said medicament is capsule, powder, powder.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1355033A (en) * | 2000-11-24 | 2002-06-26 | 张志祥 | Cancer-elimianting pill |
| CN101249235A (en) * | 2008-03-29 | 2008-08-27 | 李玉林 | Chinese medicine for curing esophagus cancer and method of preparing the same |
| CN101279071A (en) * | 2008-05-19 | 2008-10-08 | 王金贵 | Chinese medicinal composition for curing esophagus cancer or cardiac cancer |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1355033A (en) * | 2000-11-24 | 2002-06-26 | 张志祥 | Cancer-elimianting pill |
| CN101249235A (en) * | 2008-03-29 | 2008-08-27 | 李玉林 | Chinese medicine for curing esophagus cancer and method of preparing the same |
| CN101279071A (en) * | 2008-05-19 | 2008-10-08 | 王金贵 | Chinese medicinal composition for curing esophagus cancer or cardiac cancer |
Non-Patent Citations (1)
| Title |
|---|
| 国家药典委员会 编.珍香胶囊.《国家药品标准新药转正标准第73册》.2008,X73-31. * |
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