CN101239134A - 祛斑药物组合物 - Google Patents
祛斑药物组合物 Download PDFInfo
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Abstract
本发明公开了一种祛斑药物组合物及其制备方法。该祛斑药物组合物含有醋柴胡、当归、白芍、丹参、茯苓、白术、长青腾、青橘叶、制香附、枸杞子和薄荷。它可以采用中药制剂的常规方法制备成任何常规内服药剂。本发明药物有疏肝解郁、去肝胆疾病，调理气血和内分泌、让内脏血液循环正常等治本的功效，通过这种治本之功效达到祛斑美容养颜的目的。
Description
技术领域
本发明属于中药及美容品领域。主要涉及治疗由内分泌失调所引起的黄褐斑等面部色斑的祛斑药物组合物。
背景技术
黄褐斑是一种发生于颜面的色素增生性皮肤病，其临床表现以面部对称性呈蝴蝶状，或局限性淡褐色或褐色斑片为特点，好发于中青年女性。中医理论认为黄褐斑是由肝气郁滞、情志失调、思虑过度及病后失调所致，黄褐斑的产生源在脏腑，行在气血，显在体表。也就是说，内在脏腑失调是因，气血两亏，淤滞不畅是果。因此，对黄褐斑的治疗，重在疏肝解郁、调理气血和内分泌，让内脏血液循环正常。
目前，为了消除黄褐斑等面部色斑，大多数人都求助于各种美容化妆品，如市场上出售的遮盖霜、祛斑霜、消斑灵等。虽然对于黄褐斑、蝴蝶斑、雀斑也有一定地预防，遮盖作用，但是部分产品是采用激素类药物及化学物质合成，有些产品甚至含有对人体有害的铅、汞成分，使用过久会使皮肤受到不同程度的刺激和损伤。而且美容化妆品无法从根本上解决问题，停止使用后，其黄褐斑、蝴蝶斑、雀斑有可能再出现。
目前，越来越多的人倾向于采用中药有效成分治疗黄褐斑，所采用的中药种类、制备和服用方法各不相同。例如，中国专利CN1613499A采用灵芝、赤芍、红花、生地、当归、丹参、柴胡、大黄、郁金、僵蚕、黄茂、人参、甘草、苍术、白芍、沙棘、防风、三七等制成口服药物，并与外用膜组合形成复方祛斑组合中药方剂来使用。中国专利CN1091963采用中药黄芪、丹皮、桃仁、五灵脂、肉桂等26味中药经晒干、粉碎研成粉末，并制成胶囊药剂服用。中国专利CN1091963采用川夸、熟地、何首乌、桑根、旱莲花、黄精、女贞子、肉从蓉、石解、构祀子、淫阳霍、巴戟天、兔丝子、桃仁、红花、当归、赤芍药、柴胡、甘草、黑芝麻等制成汤剂服用。虽然上述祛斑药物对黄褐斑有一定的疗效，但是，在上述的祛斑药物中，使用的中药种类繁多，制作步骤复杂，导致成本上升。因此，人们期盼着一种治疗效果好、成本上经济、服用方便的治疗黄褐斑等面部色斑的良药问世。
发明内容
本发明针对上述存在的问题，提供一种能治疗根本、使用中药种类较少、制作方法简单、服用方便的祛斑药物组合物。
本发明的药物组合物是根据黄褐斑产生的病理，按照君臣佐使诸药作用显著的新药方，它可以从根本上治疗黄褐斑等面部色斑，疗效显著。
本发明的祛斑药物组合物是经过发明人进行大量摸索总结得出的，采用常见中药原料，并易于配制，成本上经济，服用方便。
本发明的祛斑药物组合物由以下重量配比的原料制成：
醋柴胡9-15份 当归8-13份 白芍7-13份
丹参11-19份 茯苓10-16份 白术7-14份
长青腾4-9份 青橘叶3-9份 制香附8-14份
枸杞子3-9份 薄荷2-6份
本发明的祛斑药物组合物优选由以下重量配比的原料制成：
醋柴胡11-14份 当归9-12份 白芍9-12份
丹参14-17份 茯苓11-14份 白术8-11份
长青腾5-8份 青橘叶5-8份 制香附9-12份
枸杞子5-7份 薄荷2-4份
本发明的祛斑药物组合物进一步地优选由以下重量配比的原料制成：
醋柴胡12份 当归10份 白芍10份 丹参15份
茯苓12份 白术10份 长青腾6份 青橘叶6份
制香附10份 枸杞子6份 薄荷3份
本发明中药原料的配比以及其它份数都是以重量份计。本发明药物可以采用中药制剂的常规方法制备成任何常规内服药剂如汤剂、片剂、胶囊剂、丸剂、粉剂等。例如，可以将上述混合物进行水煎，将上述药物混合物加入8-25份的水，加热煎制，去除固体残渣，即得药物。优选的水煎方法是，将除薄荷组分之外的原料组分于80-95℃温度下水煎0.5-2小时，然后再加入薄荷继续水煎，取其水煎液，即得本发明药物。
本发明的祛斑药物组合物中各中药的药理如下：
醋柴胡：柴胡性味苦平，入肝、胆经，可发表退热，疏肝解郁，升阳。用于感冒发烧，寒热往来，疟疾，胸胁胀痛，***。现代药理研究表明，柴胡具有解热、镇静、镇痛、抗菌、抗肝损伤、抗病毒等作用。柴胡生品升散作用较强，多用于解表退热。柴胡醋炙后能缓和升散之性，增强疏肝解郁作用。
当归：味甘、辛，性温。归肝、心、脾经。既能补血、活血，又能调经，为妇科要药。用于心肝血虚，面色萎黄，眩晕心悸等，还有血虚或血虚而兼有瘀滞的***，痛经，经闭等症。
白芍：白芍生品擅于养血敛阴，平抑肝阳。用于血虚***，痛经，崩漏，头痛，眩晕，耳鸣，烦躁易怒，以及自汗，盗汗等证。经酒炙后，能降低酸寒之性，善于和中缓急。多用于胁肋疼痛，腹痛，痛经等。
丹参：性味苦，微寒。祛瘀止痛，活血调经，养心除烦，排脓生肌。用于***，瘫瘕积聚，胸腹刺痛，心烦不眠，疮疡肿毒，肝脾肿大，心绞痛等症。
茯苓：其主要成分有菌核含B-茯苓聚糖和三萜类化合物乙酰茯苓酸、茯苓酸、3B-羟基羊毛甾三烯酸。用于小便不利，水肿胀满，痰饮咳逆，泄泻，惊悸，健忘等症。
白术：白术性温，味甘苦，含有挥发油，气味芳香。有健脾益气、利水化湿的功能。可用于治疗脾虚泄泻、水肿、痰饮等症。
青橘叶：味辛、苦，性平。归肝、胆、胃经，有疏肝理气，消肿散结之功效。可用于胁肋疼痛、疝气疼痛、食积停滞、脘腹胀满等症。
制香附：辛散苦降，甘缓性平，长于疏肝理气，又有止痛作用，并能活血调经。常用于***，经行腹痛等症。正如《本草纲目》中所述“香附之气平而不寒，香而能窜，期味多辛能散，微苦能降，微甘能和。乃气病之总司，女科之主帅”。
枸杞子：含有丰富的胡萝卜素、维生素B1、B2、C、E、多种氨基酸、亚油酸、甜菜碱、铁、钾、锌、钙、磷硒等多种美颜润肤成分。现代医学研究发现，枸杞子有增强机体免疫功能，增强机体抵抗力，促进细胞的新生，降低血中胆固醇含量，抗动脉硬化，改善皮肤弹性，抗脏器及皮肤衰老，延缓皮肤皱纹等作用。
薄荷：性寒、味辛，有解表、散风热的功能。主治外感发热、头痛、目赤、咽喉肿痛；用其茎、叶煎汤熏洗，可治各种皮肤湿疹、色斑等。因此，薄荷除在医药上有广泛的用途外，在食品工业和化妆品工业上也广泛应用。
根据祖国中医学“治病求本、扶正驱邪、活血化淤”的理论，本发明祛斑药物所选择的原料当归、丹参、制香附能活血通络；柴胡、青橘叶、制香附有疏肝化淤的功效；辅以其它中药原料白芍、茯苓、白术、枸杞子、长青腾等的健脾益气、利水化湿，养血敛阴，平抑肝阳的作用。这些药物组合使得各药物功效产生协同作用，有效地促进人体机体的新陈代谢、微循环。根据中医理论：肝血充足则心阳得生，心阳旺盛则斑消面自华。因此，本发明药物对面部色斑具有治疗根本之功效。再加上枸杞子和薄荷的美容养颜之作用，使本发明祛斑药物从根和表上同时治疗黄褐斑等面部色斑。
与现有的技术相比，本发明药物从根和表上同时治疗黄褐斑等面部色斑，治疗效果好，治愈率高，无任何副作用。而且所用的药物原料都易于从市场上获得，本发明祛斑药物的制备方法简单，因此，成本上经济，具有很强的推广应用价值。
具体实施方式
下面举出实施例进一步地说明本发明的具体实施方式，但本发明并不限于下述的实施例。
实施例1
取醋柴胡12克、当归10克、白芍10克、丹参15克、茯苓12克、白术10克、长青腾6克、青橘叶6克、制香附10克、枸杞子6克、薄荷3克，混合放入容器中，并加入1.5kg的水，用文火煎煮1小时，继续用文火煎煮25分钟，去除固体残渣，即可制得本发明的汤剂。
实施例2
取醋柴胡9克、当归12克、白芍11克、丹参12克、茯苓13克、白术10克、长青腾5克、青橘叶4克、制香附10克、枸杞子8克，混合放入容器中，并加入1.6kg的水，用文火煎煮50分钟，然后，再加入薄荷4克，继续用文火煎煮30分钟，去除固体残渣，即得本发明汤剂。
实施例3
取醋柴胡15克、当归10克、白芍8克、丹参11克、茯苓13克、白术8克、长青腾8克、青橘叶6克、制香附13克、枸杞子8克，充分晾干后，研磨成粉末，加入适量的蜂蜜，制成本发明的丸剂。
实施例4
取醋柴胡15克、当归10克、白芍8克、丹参11克、茯苓13克、白术8克、长青腾8克、青橘叶6克、制香附13克、枸杞子8克，充分晾干后，研磨成粉末，可制成本发明的粉剂或者胶囊剂。
本发明祛斑药物服用方法：一次大约200ml上述实施例1或2中的水煎药剂，分早晚各一次，每日服用一剂。5天为一个疗程，连续服用两个疗程。如制成丸剂、粉剂或者胶囊剂，可以参照“每日服用一剂，一日两次”来服用。
在临床实践中，由气血不畅、内分泌失调所引起的黄褐斑等面部色斑患者服用5-10剂也就是1-2个疗程，面部色斑即可明显消退，重患者可加服用1-2疗程。使用本发明药物对病程在3个月至12年的64例黄褐斑等面部色斑患者治疗统计：其中女57例，男7例，年龄最小19岁，最大者43岁，平均年龄33.7岁，治愈59例，达92.2％，好转3例，占4.7％，无效2例，占3.1％。
Claims (5)
1. 一种祛斑药物组合物，其特征在于，它由下述重量配比的原料制成：
醋柴胡9-15份 当归8-13份 白芍7-13份 丹参11-19份
茯苓10-16份 白术7-14份 长青腾4-9份 青橘叶3-9份
制香附8-14份 枸杞子3-9份 薄荷2-6份。
2. 如权利要求1所述的祛斑药物组合物，其特征在于，所述原料配比为：
醋柴胡11-14份 当归9-12份 白芍9-12份 丹参14-17份
茯苓11-14份 白术8-11份 长青腾5-8份 青橘叶5-8份
制香附9-12份 枸杞子5-7份 薄荷2-4份。
3. 如权利要求2所述的祛斑药物组合物，其特征在于，所述原料配比为：
醋柴胡12份 当归10份 白芍10份 丹参15份
茯苓12份 白术10份 长青腾6份 青橘叶6份
制香附10份 枸杞子6份 薄荷3份。
4. 如权利要求1-3任一项所述的祛斑药物组合物，其特征在于，采用中药制剂的常规方法制成内服的祛斑药物汤剂、粉剂、片剂、丸剂或胶囊剂。
5. 如权利要求4所述的祛斑药物汤剂，其特征在于，采用水煎法制成汤剂，将除薄荷外的其它组分在80-95℃温度下水煎，然后加入薄荷继续水煎，制成汤剂。
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139034A (zh) * | 2011-04-07 | 2011-08-03 | 王勇勤 | 一种治疗黄褐斑的药物 |
| CN102430026A (zh) * | 2011-12-01 | 2012-05-02 | 邵佳爱 | 祛斑药物 |
| CN105213668A (zh) * | 2015-10-31 | 2016-01-06 | 孙太辉 | 一种治疗面部黄褐斑的药物及其制备方法 |
| CN106668762A (zh) * | 2016-12-12 | 2017-05-17 | 金乡县金醫堂保健食品有限公司 | 一种具有祛黄褐斑、疮毒和痤疮的中药制剂 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139034A (zh) * | 2011-04-07 | 2011-08-03 | 王勇勤 | 一种治疗黄褐斑的药物 |
| CN102430026A (zh) * | 2011-12-01 | 2012-05-02 | 邵佳爱 | 祛斑药物 |
| CN105213668A (zh) * | 2015-10-31 | 2016-01-06 | 孙太辉 | 一种治疗面部黄褐斑的药物及其制备方法 |
| CN106668762A (zh) * | 2016-12-12 | 2017-05-17 | 金乡县金醫堂保健食品有限公司 | 一种具有祛黄褐斑、疮毒和痤疮的中药制剂 |
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