CN101214290B - Powder for dispersing blood stasis - Google Patents
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- CN101214290B CN101214290B CN2008100650983A CN200810065098A CN101214290B CN 101214290 B CN101214290 B CN 101214290B CN 2008100650983 A CN2008100650983 A CN 2008100650983A CN 200810065098 A CN200810065098 A CN 200810065098A CN 101214290 B CN101214290 B CN 101214290B
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Abstract
Xiaoyusan made from Chinese herbal medicines pertains to an external medicine, which is mainly applicable to the treatment of acute soft tissue injury. The finished product of Xiaoyusan is powder, including the following components such as Chinese teasel root, tree peony bark, angelica, rhizome curcumae, sedge grass, Pu-Huang, red paeonia, gardenia, notopterygium root and mint. The present invention has the characteristics of significant curing effect, convenient use, low price, etc.
Description
Technical field
The present invention relates to a kind of external Chinese powder medicine one powder for dispersing blood stasis, be applicable to the treatment of acute soft tissue injury.
Background technology
Soft tissue injury is a kind of commonly encountered diseases and frequently-occurring disease, the Chinese medicine that is used for the treatment of soft tissue injury also has, mainly contain YUNNAN BAIYAO, Flos Carthami wet goods, in addition, the medicine that also has some patent applied fors, as application number is that 01137315.0 patent application discloses a kind of medicine of being made up of Radix Et Rhizoma Rhei powder, mirabilite powder, rifampicin powder, cefalexin powder, and this medicine is non-pure Chinese medicine; As application number is that 200610104699.1 patent application also discloses a kind of medicine of being made up of seed of Arillus Longan, Borneolum Syntheticum.Said medicine, the prescription that has is single, and the effect that has is lower, and taking effect of having is slow, can not satisfy current clinical needs in a word.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine " powder for dispersing blood stasis " that is used for the treatment of acute soft tissue injury,,, can effectively satisfy current clinical needs through a large amount of clinical observation on the therapeutic effect by selected compound recipe.
Realize that technical scheme of the present invention is: the Main Ingredients and Appearance of this medicine comprises Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, and the weight ratio between each composition is a Radix Et Rhizoma Rhei: Cortex Moutan: the Radix Angelicae Dahuricae equals 10～30: 4～6: 4～6.
This technical scheme also comprises: the composition of this medicine also comprises Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Rhizoma Cyperi, Pollen Typhae, Radix Paeoniae Rubra, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Herba Menthae, and the weight ratio between each composition is a Radix Et Rhizoma Rhei: Cortex Moutan: the Radix Angelicae Dahuricae: Rhizoma Curcumae Longae: Rhizoma Cyperi: Pollen Typhae: Radix Paeoniae Rubra: Fructus Gardeniae: Rhizoma Et Radix Notopterygii: Herba Menthae equals 10～30: 4～6: 4～6: 4～6: 8～12: 4～6: 4～6: 8～12: 1～4: 1～4.
Above-mentioned prescription also comprises: Radix Et Rhizoma Rhei: Cortex Moutan: the Radix Angelicae Dahuricae: Rhizoma Curcumae Longae: Rhizoma Cyperi: Pollen Typhae: Radix Paeoniae Rubra: Fructus Gardeniae: Rhizoma Et Radix Notopterygii: Herba Menthae equals 10～15: 4～5: 4～5: 4～5: 8～10: 4～5: 4～5: 8～10: 2～3: 2～3.
The preparation method of above-mentioned medicine is: Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Rhizoma Cyperi, Pollen Typhae, Radix Paeoniae Rubra, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Herba Menthae are mixed grinding to the powder by proportioning, 80～100 orders sieve, it is an amount of to add water, edible rice vinegar, wine, Mel then, and the furnishing paste is finished product (excipient modulation external application).
The beneficial effect that the present invention has: 1. natural resources of Chinese medicinal materials is abundant, draws materials conveniently, and is cheap, evident in efficacy, has no side effect.2. Chinese medicine is mixed with paste, carries, easy to use.3. quick anti-inflammatory analgetic, curative effect is better than other similar medicine.
The specific embodiment
Embodiment:
Prescription: get Radix Et Rhizoma Rhei 10 grams, Cortex Moutan 4 grams, the Radix Angelicae Dahuricae 4 grams, Rhizoma Curcumae Longae 4 grams, Rhizoma Cyperi 8 grams, Pollen Typhae 4 grams, Radix Paeoniae Rubra 4 grams, Fructus Gardeniae 8 grams, Rhizoma Et Radix Notopterygii 2 grams, Herba Menthae 2 grams.
Preparation: Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Rhizoma Cyperi, Pollen Typhae, Radix Paeoniae Rubra, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Herba Menthae are ground to the powder by the proportioning mixing, and 80～100 orders sieve.
Usage: it is an amount of that the magistral medicines after will sieving adds water, edible rice vinegar, wine, Mel, and the furnishing paste applies in injury region (excipient modulation external application).
Curative effect:
Acute soft tissue injury patient 598 examples are treated with powder for dispersing blood stasis external application injury region, and carry out clinical efficacy and safety paired observation thereof with matched group (Shuangbo County loose) 96 examples, result: powder for dispersing blood stasis treatment acute soft tissue injury clinical cure rate 74.92%, obvious effective rate 92.14%, total effective rate 98.33% has no adverse reaction.
Matched group clinical cure rate 63.54%, obvious effective rate 79.17%, 88.54%, two group of curative effect of total effective rate has significant difference (p＜0.05).
Clinical data
One, case choice criteria is a foundation with " new Chinese medicine clinical research guideline ", formulates following standard with regard to acute soft tissue injury.
(1) diagnostic criteria
1. Western medicine diagnose standard: 1. tangible trauma history is arranged, sharp ache, local swelling rapidly, limb activity dysfunction.2. the injury tenderness is obvious, local livid purple ecchymosis can occur, and ecchymosis can appear in severe patient, and the positive is levied in fluctuation.3. damage in back 3 days.4. the X ray examination mainly is to get rid of fracture, dislocation and osteopathia etc.
2. tcm syndrome diagnostic criteria: 1. qi stagnation and blood stasis type.2. blood deficiency cold-condensing type.
(2) include standard in
(1) meets the Western medicine diagnose standard.
(2) meet the tcm syndrome diagnostic criteria.
(3) being tried the age is 18～60 years old.
(3) exclusion standard
(1) do not meet acute soft tissue injury diagnostic criteria person.
(2) do not belong to case in the drug effect scope.
(3) obviously hold concurrently folder card or complication person are arranged.
(4) suckling gestation or the women that just preparing gestation.
(5) allergic constitution reaches multiple drug allergy person.
(6) merge serious primary disease such as Liver and kidney, hemopoietic system, hormonal system and psychotic.
(7) state of an illness critical, be difficult to definite estimator is done in the effectiveness and the safety of new drug.
Two, severity extent by the symptom scalar quantization standard of " new Chinese medicine clinical research guideline " be divided into gently, in, weigh three grades.
Three, physical data
Include the case that this group is observed acute soft tissue injury, 18～60 years old age in according to above-mentioned guideline; The course of disease 1～3 day, sky, average 2 (± 0.5); 5 days courses of treatment, average is skies, 4 (± 0.5).The treatment group is with the powder for dispersing blood stasis external application, and matched group is with the diffusing external application in Shuangbo County.Its two groups of clinical datas are auspicious to see Table 1, table 2.
Table 1 liang group patient age, sex, source, the state of an illness, and traditional Chinese medical science typing information slip
| Group | Age (year) | Sex (example) | The patient source | The state of an illness | Typing | Total routine number | |||||
| x±s | The man | The woman | The door ginseng | Be in hospital | Gently | In | Heavy | The bent stasis of blood type of the stagnation of QI | The blood deficiency cold-condensing type | ||
| Treatment group matched group | 28.2±11.3 27.3±10.9 | 321 54 | 277 42 | 330 58 | 268 38 | 201 34 | 198 33 | 199 29 | 583 92 | 15 4 | 598 96 |
| Statistical value x 2 | 1.11 | 0.69 | 0.70 | 3.26 | 1.39 | ||||||
Statistics shows that two groups of patients compare there was no significant difference (p＞0.05) aspect age, sex, source, the state of an illness and traditional Chinese medical science typing.
Table 2 injury distribution (example)
| Group | Shoulder | Ancon | Hand | Forearm | Chest | The back | Waist | Sacrococcygeal region | Buttocks | Knee | Ankle and foot | Sum (example) |
| Treatment group matched group | 29 6 | 84 16 | 106 12 | 24 7 | 12 2 | 42 5 | 21 8 | 30 5 | 37 3 | 34 9 | 179 23 | 598 96 |
Through the SPSS software analysis, t=1.647, two groups of difference not statistically significants (p＞0.05).
Therapeutic Method
The powder for dispersing blood stasis medicine is formed and using method: prescription is made up of 10 flavor Chinese medicines such as Radix Et Rhizoma Rhei, Rhizoma Curcumae Longae, Rhizoma Cyperi, Herba Menthae etc.Method for making: medicine-feeding grinds to the powder in right amount altogether, and 80～100 orders sieve.Usage: the powder of getting it filled adds that water, edible rice vinegar, wine, Mel are an amount of, and the furnishing paste applies at injury region, thickness 0.5cm, the ointment area is more bigger than swelling area, applies lid with special-purpose gummed paper, the heart will the time wrap up fixingly, change dressings once every day.The medicine that Shuangbo County looses is made up of 2 parts of Cacumen Platycladis, 1 part of Cortex Phellodendri, Radix Et Rhizoma Rhei part 2,1 part of Herba Menthae, 1 part of Herba Lycopi.Grind to the powder altogether, standby, usage and powder for dispersing blood stasis are together.
Therapeutic outcome
One, observation index and efficacy evaluation, the standard according to " new Chinese medicine clinical research guideline " is divided into recovery from illness, produce effects, effective, invalid.
Treat and evaluate curative effect after 5 days, less than 5 days was that cured person is discontinued medication, and the evaluation curative effect.Two groups of case root a tree name observation index and efficacy evaluation statistical result see that the average cure time of 3 powder for dispersing blood stasis groups is 3.12 (± 0.54) day, and Shuangbo County's average cure time of group that looses is 4.21 (± 0.57) day; By controlled observation, the result shows that powder for dispersing blood stasis group curative effect is better than the diffusing group in Shuangbo County, and both learn to handle by statistics significant difference (p＜0.05), illustrates that treatment group curative effect is better than matched group.The medication after damage of this medicine is more early good more.Do not find its untoward reaction.The powder for dispersing blood stasis group has 9 examples, matched group to have 2 routine patient skins and medicine contact position that the rubescent phenomenon of mild skin is arranged, and promptly disappears after stopping using.
Treatment soft tissue injury clinical observation on the therapeutic effect looses for table 3 powder for dispersing blood stasis, Shuangbo County
| Group | n | Recovery from illness (%) | Produce effects (%) | Effectively (%) | Invalid (%) | Total effective rate (%) |
| Treatment group matched group | 598 96 | 448(74.92) 61(63.54) | 103(17.22) 15(15.63) | 37(6.19) 9(9.38) | 10(1.67) 11(11.46) | 98.33 88.54 |
Two groups of curative effects are analyzed through Ridit, μ=1.98, and p＜0.05, difference has statistical significance.
Conclusion
External treatment of tcm is a kind of important method of Chinese therapeutics, is widely used aspects such as card, arthromyodynia, the fracture injury of tendon and muscle, arthritis, osteopathia bitterly in the stasis of blood of orthopedics department.Acute soft tissue injury is the bone injury common clinical, and external treatment side's medicine is more, and is evident in efficacy mostly.
External used medicine is closed to skin, has a thorough knowledge of among grain of meat, flavour of a drug is penetrated skin so that grain of meat and through meridians import internal organs into, to regulate internal organs negative and positive of qi and blood, strengthening vital QI to eliminate pathogenic factors, thereby cure diseases.Wu Shangxian is pointed out in " the theoretical parallel prose ": " reason of external treatment is the reason of treatment by oral administration of medicines; the medicine of external treatment is the medicine of treatment by oral administration of medicines; different person's method ear, and the medical knowledge property of medicine does not have two, and the magical change of rule ", " external treatment must be as the treatment by oral administration of medicines person; ask it earlier, and this person He-Ming negative and positive knows internal organs also ...; though control outside not different from controlling also interior.So parallel with treatment by oral administration of medicines, and can mend treatment by oral administration of medicines not as good as the person, this also "." make the property of medicine go into its space between skin and muscles from pore, stimulate the menstrual flow and pass through network, or carry it, or attack and loose it, it is outstanding strong to take medicine ".Modern medicine study is thought: skin enters the mouth as an administration, behind the topical, Chinese medicine externals such as blood circulation promoting and blood stasis dispelling are by mucocutaneous transhipment, and major part directly enters medicine-feeding part generation drug effect, medicine can be absorbed by the capillary of skin net simultaneously, enters blood circulation and again whole body is had an effect.The microcirculation of local organization is improved, improved the metabolism of local organization.And the treatment by oral administration of medicines medicine will be prone to blood medicine peak valley phenomenon through links such as digestion, absorption, transhipments to drug degradation and liver first-pass effect, and individual difference is big, and Chang Buneng reaches desirable curative effect, and side effect is more.Good topical therapeutic effect, minimum side effect makes external therapy of tcm occupy the critical positions of orthopedics department.
Powder for dispersing blood stasis cures mainly acute soft tissue injury (syndrome of blood stasis).Radix Et Rhizoma Rhei is monarch in the side, energy removing pathogenic heat from blood and toxic substance from the body, promoting blood circulation to restore menstrual flow; Rhizoma Curcumae Longae, Rhizoma Cyperi are minister, and the promoting flow of QI and blood pain relieving is equipped with the refrigerant table of walking of Herba Menthae for making.All medicine mutually 5 is played the merit of promoting flow of QI and blood, repercussive pain relieving altogether.And can effectively prevent and treat the blood stasis heat-transformation.Modern pharmacological research confirms that Radix Et Rhizoma Rhei, Rhizoma Cyperi, Herba Menthae also have anti-inflammatory properties, and Rhizoma Curcumae Longae, Rhizoma Cyperi, Herba Menthae have analgesic activity.Totally 5 to play QI and blood logical for all medicines, and pain is ended, the therapeutic effect that swelling disappears.Find with the clinical efficacy comparative observation that Shuangbo County looses, powder for dispersing blood stasis treatment acute soft tissue injury, curative effect is more excellent, does not find obvious toxic-side effects, and skin does not have obvious irritation, is medicine for external use safely and effectively, and is economical convenient.
Shuangbo County looses and to be the late professor of Traditional Chinese Medicine University Of Guangzhou, the yellow credit of the Guangdong Province's distinguished veteran doctors of TCM Protestantism proved recipe of instructing the sutra.This side mainly is made up of Radix Et Rhizoma Rhei, Cacumen Platycladi, Herba Lycopi, Cortex Phellodendri, Herba Menthae, and reducing swelling and alleviating pain is arranged, and the merit of blood circulation promoting and blood stasis dispelling is used for acute soft tissue injury and fracture is early stage.This side's curative effect is used more extensive certainly.Powder for dispersing blood stasis compares with it, and two sides are monarch drug with the Radix Et Rhizoma Rhei; Blood circulation promoting and blood stasis dispelling is all arranged, the merit of reducing swelling and alleviating pain; But the Rhizoma Curcumae Longae blood-activating and qi-promoting is arranged, wind-expelling pain-stopping, medicine promoting the circulation of QI to relieve pain such as Rhizoma Cyperi in the powder for dispersing blood stasis side; So the merit of promoting the circulation of QI to relieve pain is good especially.And the diffusing promoting the circulation of QI to relieve pain in Shuangbo County are inferior slightly.Shuangbo County looses owing to medicine character reason in addition, be processed as powder after granule thicker, influence absorbs and dermal sensation easily.
Powder for dispersing blood stasis treatment acute soft tissue injury has characteristics such as rapid-action, evident in efficacy, that the course of treatment is shorter, and is easy to use, is worth applying clinically.We's medicine composition is easy, the cheap Chinese medicine of drawing materials, and easily is processed into fine and smooth medicated powder.Loose relatively with Shuangbo County, the protogenic medicinal powder of same quality, price is suitable.
In sum, powder for dispersing blood stasis treatment acute soft tissue injury is evident in efficacy, easy to use, and low price is better than Shuangbo County and looses.
Proportioning of the present invention can suitably be amplified, and some composition can be replaced with other composition that identical function is arranged.
Claims (3)
1. powder for dispersing blood stasis, by prepared from traditional Chinese medicines, belong to application compress, it is applicable to the treatment of acute soft tissue injury, the finished product that it is characterized in that this powder for dispersing blood stasis is a powder, its composition is made up of Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Rhizoma Cyperi, Pollen Typhae, Radix Paeoniae Rubra, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Herba Menthae, and the weight ratio between each composition is a Radix Et Rhizoma Rhei: Cortex Moutan: the Radix Angelicae Dahuricae: Rhizoma Curcumae Longae: Rhizoma Cyperi: Pollen Typhae: Radix Paeoniae Rubra: Fructus Gardeniae: Rhizoma Et Radix Notopterygii: Herba Menthae equals 10～30: 4～6: 4～6: 4～6: 8～12: 4～6: 4～6: 8～12: 1～4: 1～4.
2. powder for dispersing blood stasis as claimed in claim 1, it is characterized in that the weight ratio between described each composition is a Radix Et Rhizoma Rhei: Cortex Moutan: the Radix Angelicae Dahuricae: Rhizoma Curcumae Longae: Rhizoma Cyperi: Pollen Typhae: Radix Paeoniae Rubra: Fructus Gardeniae: Rhizoma Et Radix Notopterygii: Herba Menthae equals 10～15: 4～5: 4～5: 4～5: 8～10: 4～5: 4～5: 8～10: 2～3: 2～3.
3. the preparation method of powder for dispersing blood stasis according to claim 1 and 2 is characterized in that Radix Et Rhizoma Rhei, Cortex Moutan, the Radix Angelicae Dahuricae, Rhizoma Curcumae Longae, Rhizoma Cyperi, Pollen Typhae, Radix Paeoniae Rubra, Fructus Gardeniae, Rhizoma Et Radix Notopterygii, Herba Menthae are mixed pulverization by proportioning, and 80～100 orders that sieve are powder.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101975721B (en) * | 2010-09-03 | 2012-06-13 | 中国农业大学 | Method and device for simulating straw compression molding |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104383140A (en) * | 2014-10-24 | 2015-03-04 | 许炎武 | Medicine composition for treating scalp hematoma |
| CN106729430A (en) * | 2017-01-17 | 2017-05-31 | 王维 | One kind attacks cancer powder medicine (Zhuyusan) and its application |
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Non-Patent Citations (3)
| Title |
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| 刘兴利，何大新，彭力平等.三维正脊仪配合消瘀散外敷治疗腰椎间盘突出症.吉林中医药.2006,26(2),49-50. * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101975721B (en) * | 2010-09-03 | 2012-06-13 | 中国农业大学 | Method and device for simulating straw compression molding |
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